US20060058642A1 - Method for acquiring electromagnetic signals and contrast product therefor - Google Patents
Method for acquiring electromagnetic signals and contrast product therefor Download PDFInfo
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- US20060058642A1 US20060058642A1 US10/538,826 US53882605A US2006058642A1 US 20060058642 A1 US20060058642 A1 US 20060058642A1 US 53882605 A US53882605 A US 53882605A US 2006058642 A1 US2006058642 A1 US 2006058642A1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
- G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
Definitions
- the present invention relates to the acquisition of electromagnetic signals. It relates more particularly to the acquisition of such signals received from a body part, in particular a human or animal body part, in response to an external electromagnetic solicitation.
- MRI magnetic resonance imaging
- the body part imaged is then subjected to a radiofrequency wave applied perpendicular to the magnetic induction B 0 and the frequency of which is typically adjusted to the Larmor precession frequency of the hydrogen nucleus in the magnetic induction B 0 in question.
- This frequency is proportional to the intensity of the magnetic induction B 0 and has the specificity of bringing into resonance the protons of the hydrogen contained in the water molecules of the body.
- the corresponding Larmor frequency is in the region of 42 MHz.
- each water proton that has come into resonance creates, as a result, a relatively weak electromagnetic signal, called a magnetic resonance signal.
- This signal can then be detected by means of an appropriate detection module.
- Gradients of the magnetic induction B 0 can be used in various spatial directions, so as to have different induction values between two points in space, each corresponding to an elementary volume of the body in question.
- the use of magnetic induction B 0 gradients therefore allows spatial localization of the signal.
- the step of coding the space by means of the gradients is carried out between the proton excitation and the magnetic resonance signal reception.
- time of flight In a first method, referred to as “time of flight” method, the radio frequency waves are transmitted repeatedly and regularly, in a train of pulses. The repetition of these waves is adjusted so as to be sufficiently frequent for the proton relaxation not to have time to be entirely complete before transmission of the next wave. This saturation phenomenon means that the magnetic resonance signal is greatly reduced. It virtually makes it possible to eliminate the signals transmitted by the immobile protons, i.e. typically the protons that are part of tissues of the body in question.
- mobile protons that penetrate the zone in question without having been subjected beforehand to a train of pulses come into resonance and create a magnetic resonance hypersignal that can be detected.
- the mobile protons are typically the protons contained in the water of the circulating blood.
- This time of flight method therefore makes it possible to distinguish between the relaxed mobile protons and the saturated immobile protons and thus makes it possible to isolate a selective signal corresponding, for example, to a blood activity.
- This method can in particular be applied in the field of angiography, since it makes it possible to detect a signal originating from a blood vessel in particular.
- phase contrast takes advantage of the relationship that exists between the phase of the detected magnetic resonance signal and the rate of proton displacement in the body in question, to allow detection of blood vessels within the body.
- this method has drawbacks insofar as a prior estimation of the rate of circulation in the vessels is necessary.
- the phase is a quantity expressed to within 2 ⁇ , an ambiguity remains regarding the effective rate deduced from a magnetic resonance signal.
- a third method has made a name for itself in the last few years in the angiography field. It comprises a step consisting in injecting a contrast product into a body.
- the contrast product used is gadolinium attached to a chelating agent such as DOTA (or tetraazacyclododecane tetraacetate) or DTPA (or diethylenetriamine pentaacetate).
- the chelating agent is a molecular cage that surrounds the gadolinium and makes it possible to limit its toxicity with respect to the body into which it is injected.
- the effect of this product is to decrease the relaxation time of the protons that are in proximity.
- the contrast product contains single unpaired electrons which have a paramagnetic effect that acts on the water protons.
- the contrast product moves in the blood vessels without being absorbed by the surrounding tissues. Detection of the magnetic resonance signals therefore makes it possible to distinguish between the blood vessels and the surrounding tissues and also to form an image revealing this distinction.
- paramagnetic gadolinium in addition to its action on proton relaxation time, creates magnetic induction microgradients that result in local distortions of the magnetic induction to which the body is subjected.
- the frequencies of the waves transmitted are dispersed. This effect can result in the loss of certain signals.
- the magnetic resonance signals are used to form an image of a zone of the body in question, said image will therefore be difficult to interpret.
- this method does not allow complete suppression of the signals derived from tissues lacking contrast product.
- An object of the present invention is to provide a method for acquiring magnetic resonance signals that limits the problems encountered in the above techniques.
- the observed zone may contain substantially mobile or substantially immobile protons. It may be a blood vessel or a vascularized network, but also an organ, a group of cells, or the like.
- the invention thus proposes a method for acquiring electromagnetic signals received from at least one part of a body placed in a system comprising means for generating a magnetic induction B 0 , said magnetic induction comprising gradients in certain directions in space, means for transmitting radio frequency wave pulse sequences perpendicular to the magnetic induction B 0 in a range of adjustable frequencies, and means for detecting electromagnetic signals received from said body part.
- the method comprises the following steps:
- the chemical shift provided by the contrast product brings about a shift in the resonance frequency of the hydrogen protons contained in the water in proximity to the injected contrast product.
- This shift in frequency makes it possible to obtain a selective signal from the protons chemically shifted during a radio frequency-based solicitation taking into account this shift.
- Such selective signal can advantageously be used as a basis for forming an image.
- the observed zone envisioned here may be of various types, for instance a blood vessel, a group of cells expressing a gene, a tumor zone, or the like.
- the invention also proposes a contrast product intended to be injected into at least one part of a body for the purpose of acquiring electromagnetic signals from said body part.
- This product comprises at least one element capable of causing a chemical shift of a resonance frequency of water hydrogen protons.
- the element included in the contrast product may advantageously be a lanthanide, for example dysprosium, praseodymium and/or europium, optionally attached to a chelating agent, or any other element capable of inducing a modification of the resonance frequency.
- a lanthanide for example dysprosium, praseodymium and/or europium, optionally attached to a chelating agent, or any other element capable of inducing a modification of the resonance frequency.
- FIGURE is a simplified representation of an observed zone to which the invention is applied.
- an amount of contrast product is injected into a body 4 , which may be, for example, a human or animal body, but which may also be an inert body.
- the injection is performed in such a way that the contrast product is fixed at least temporarily in or passes through an observed zone 1 .
- the contrast product may be injected intravenously.
- the observed zone may then comprise a blood vessel 2 through which the contrast product passes, and also the tissues 3 that surround this vessel.
- the contrast product used according to the invention has the property of effecting a chemical shift on the hydrogen protons that are in proximity thereto. This is because such a product contains atoms whose electron cloud is capable of modifying the local magnetic induction experienced by the nucleus observed.
- the protons that are in proximity to the contrast product for example the protons contained in the hydrogen of the water of the blood circulating in the vessel 2 , are subjected to this magnetic induction.
- the Larmor frequency v 0 63 MHz, and a frequency shift v 1 ⁇ v 0 ⁇ 220 Hz is therefore obtained between the protons that are in proximity to or not in proximity to the contrast product.
- the chemical shift property is not inherent to all products.
- gadolinium commonly used as a contrast agent for its properties of reducing the proton relaxation time as explained in the introduction, causes virtually no chemical shift.
- three other elements of the lanthanide family are notable for their chemical shift action. These are dysprosium (Dy), praseodymium (Pr) and europium (Eu).
- cages are used to surround the lanthanides in order to limit their toxicity, as was the case for gadolinium.
- These cages are typically chelating agents such as DOTA or DTPA.
- the contrast product used is therefore advantageously a lanthanide chelate capable of generating a chemical shift, such as Dy-DOTA, Dy-DTPA, Pr-DOTA or Pr-DTPA.
- the body 4 is placed, immediately before or after injection of the contrast product, in a system that surrounds a part of the body and that is capable of generating a high-amplitude magnetic induction B 0 .
- This induction comprises gradients in principle directions in space according to the type of information that it is desired to acquire. For example, if it is desired to obtain magnetic resonance signals for elementary volumes in three-dimensional space, it will be advisable to introduce coding gradients G x , G y and G z for the magnetic induction B 0 in three main perpendicular directions (x, y, z) in space, in a manner known in itself. By means of this technique, magnetic induction values that are different between elementary volumes of the body 4 are ensured.
- the system in which the body 4 is placed also has a transmitter of radio frequency wave pulse sequences in a range of adjustable frequencies that may be more or less selective, according to the duration of transmission of the corresponding waves.
- These RF waves are transmitted perpendicular to the direction of the magnetic induction B 0 .
- a wave is transmitted at a frequency corresponding to the proton resonance frequency, said protons are then taken out of their equilibrium position in a direction close to that of the induction B 0 , and then they gradually return to this equilibrium position.
- the protons in proximity to the injected contrast product have a resonance frequency that is shifted with respect to the usual Larmor frequency. Advantage is then taken of this particularity in order to recover electromagnetic signals only from these chemically shifted protons.
- a radio frequency wave pulse sequence is transmitted with a frequency adjusted selectively to the value of the frequency shifted due to the chemical shift, i.e. v 1 according to the notation employed above.
- a reception module detects and evaluates the transmitted magnetic resonance signal. According to the principle explained above, only the protons in the vessel 2 of the example illustrated in the FIGURE come into resonance and generate a magnetic resonance signal. The other protons that are not in proximity to the injected contrast product, i.e. typically the protons present in the tissues 3 , generate virtually no signal.
- an image of the observed zone 1 is realized, for example in a spatial plane, by taking advantage of the magnetic induction gradients, and with each point of the image corresponding substantially to a detected signal value, as a function of its geographical position in the plane under consideration according to a conventional spatial coding, the zones where the contrast product has been fixed can be clearly distinguished. An image is thus obtained, where the vessel 2 will be visible, while the tissues 3 will be invisible.
- This embodiment is therefore entirely advantageous.
- it has the drawback of requiring a sequence of radio frequency transmissions that are selective with respect to frequency, which means that a considerable transmission time is needed.
- the signal acquisition time may prove to be disadvantageous.
- a second advantageous embodiment makes it possible to limit the magnetic resonance signal acquisition time. It consists in using a radio frequency wave pulse transmission sequence comprising a first series of selective wave pulses adjusted to a frequency corresponding substantially to the Larmor frequency for the water protons not chemically shifted, i.e. the protons of the tissues 3 in the example illustrated. These waves are transmitted with a sufficient duration to saturate the protons concerned, to such an extent that these protons no longer transmit any significant magnetic resonance signal at the end of the first series of wave pulses.
- the radio frequency wave transmission sequence also comprises a second series of wave pulses that are relatively nonselective in terms of frequency, each wave of the sequence being transmitted over a short period of time.
- the range of frequencies covered by these waves comprises the resonance frequency of the chemically shifted protons, i.e. of the protons of the vessel 2 .
- the protons of the tissues 3 being saturated. This makes it possible to rapidly receive the signals coming from only the protons of the vessel 2 .
- the signals transmitted by the chemically shifted protons are isolated with precision.
- the contrast products used with dysprosium, praseodymium or europium have only a limited action on the distortion of the magnetic induction in the observed zone, through the creation of magnetic induction microgradients, unlike gadolinium.
- the images obtained by applying this technique therefore potentially have a greater spatial resolution than the known techniques using gadolinium chelates.
- the chemical shift engendered by injection of the contrast product for example dysprosium, as a function of the concentration of the latter.
- This prior knowledge can make it possible to precisely select the frequency of the wave to be transmitted in the observed zone.
- it is possible to determine the frequency resulting from the chemical shift without prior knowledge.
- the observed zone 1 of the body 4 is subjected to successive waves in a broad spectrum of radiofrequencies and the magnetic resonance signals generated by the observed zone in reaction to each of these waves are detected.
- the main frequency that causes the protons of the observed zone having undergone the chemical shift to come into resonance is then deduced therefrom.
- the observed zone 1 illustrated in the FIGURE, has been taken to comprise a blood vessel 2 surrounded by tissues 3 .
- This representation makes it possible to envision applications of the present invention in the angiography field.
- the invention can also be applied to other types of observed zones.
- the observed zone may comprise a target, which may, for example, be a cell, a molecule, a protein, or a group of targets of the body under consideration, such as a group of cells expressing a gene.
- a known targeting molecule is advantageously attached to the contrast product injected into the body, such that the latter is temporarily fixed in the target.
- the steps described above can then be carried out so as to acquire magnetic resonance signals coming from the target only, with the exclusion of certain surrounding tissues in which the contrast product has not been fixed.
- This embodiment is particularly advantageous and finds applications in the field of cellular and molecular imaging, for example for studying gene expression in vivo, for localizing a particularly biological activity, or the like.
- the observed zone may also be a zone of angiogenesis, for example a tumor zone.
- a zone generally comprises a vascularized network, the vascularization index of which gives an indication regarding the malignant or benign nature of the tumor.
- the invention makes it possible to determine such a vascularization index.
- the lanthanide chelate used as contrast product is injected so as to be temporarily fixed in the tumor zone.
- the resonance frequency of the protons located in the vascularized network present in the tumor zone is deduced therefrom, this resonance frequency being substantially the frequency for which magnetic resonance signals were received (outside the conventional Larmor frequency of the water protons not having experienced a chemical shift).
- this operation can be carried out several times at successive moments so as to make it possible to monitor any change in the time of this resonance frequency.
- the chemical shift caused by the contrast product is proportional to the concentration of dysprosium. Determination of the resonance frequency in the tumor zone, which is itself proportional to the chemical shift, then gives an indication of the concentration of contrast product fixed in the observed zone. It is therefore understood that this indication constitutes a vascularization index that can be taken into account in a subsequent analysis of the tumor.
- the magnetic resonance signals coming from the tumor zone can be acquired so as to characterize in greater detail the vascularized network present in the tumor zone.
- An image of the zone can also be obtained from this acquisition.
Abstract
Description
- The present invention relates to the acquisition of electromagnetic signals. It relates more particularly to the acquisition of such signals received from a body part, in particular a human or animal body part, in response to an external electromagnetic solicitation.
- Various methods for acquiring signals are known, in particular in the magnetic resonance imaging (MRI) field. These methods have common characteristics.
- They generally consist in subjecting the body in question to a high-intensity magnetic induction B0, typically between 0.1 and 3 Tesla. The effect of this induction is to orient the magnetic moments of the protons of the hydrogen contained in the water molecules of the body in a direction close to the main direction of the magnetic induction B0.
- The body part imaged is then subjected to a radiofrequency wave applied perpendicular to the magnetic induction B0 and the frequency of which is typically adjusted to the Larmor precession frequency of the hydrogen nucleus in the magnetic induction B0 in question. This frequency is proportional to the intensity of the magnetic induction B0 and has the specificity of bringing into resonance the protons of the hydrogen contained in the water molecules of the body. By way of example, for an induction B0 of 1 Tesla, the corresponding Larmor frequency is in the region of 42 MHz.
- Immediately after the transmission of this radio frequency wave, the magnetic moments that have been subjected to the wave begin to oscillate around their equilibrium position and again take up a position along their original direction, close to that of the magnetic induction B0. This phenomenon is known as proton relaxation.
- During the relaxation, each water proton that has come into resonance creates, as a result, a relatively weak electromagnetic signal, called a magnetic resonance signal. This signal can then be detected by means of an appropriate detection module.
- Gradients of the magnetic induction B0 can be used in various spatial directions, so as to have different induction values between two points in space, each corresponding to an elementary volume of the body in question.
- The use of magnetic induction B0 gradients therefore allows spatial localization of the signal. The step of coding the space by means of the gradients is carried out between the proton excitation and the magnetic resonance signal reception.
- These basic principles give rise to different methods of exploitation so as to allow the production of a selective image for a chosen element of the body observed, for example a blood vessel.
- In a first method, referred to as “time of flight” method, the radio frequency waves are transmitted repeatedly and regularly, in a train of pulses. The repetition of these waves is adjusted so as to be sufficiently frequent for the proton relaxation not to have time to be entirely complete before transmission of the next wave. This saturation phenomenon means that the magnetic resonance signal is greatly reduced. It virtually makes it possible to eliminate the signals transmitted by the immobile protons, i.e. typically the protons that are part of tissues of the body in question.
- On the other hand, mobile protons that penetrate the zone in question without having been subjected beforehand to a train of pulses come into resonance and create a magnetic resonance hypersignal that can be detected. The mobile protons are typically the protons contained in the water of the circulating blood.
- This time of flight method therefore makes it possible to distinguish between the relaxed mobile protons and the saturated immobile protons and thus makes it possible to isolate a selective signal corresponding, for example, to a blood activity. This method can in particular be applied in the field of angiography, since it makes it possible to detect a signal originating from a blood vessel in particular.
- It is, however, limited to the analysis of blood vessels that are short and have a high flow rate, since, if the opposite is true, the protons contained in the blood circulating in these vessels rapidly undergoes saturation, like the protons of the surrounding tissues.
- A second method, referred to as “phase contrast” method, takes advantage of the relationship that exists between the phase of the detected magnetic resonance signal and the rate of proton displacement in the body in question, to allow detection of blood vessels within the body. However, this method has drawbacks insofar as a prior estimation of the rate of circulation in the vessels is necessary. In addition, since the phase is a quantity expressed to within 2π, an ambiguity remains regarding the effective rate deduced from a magnetic resonance signal.
- These first two methods are therefore based on characteristics associated with a displacement, in particular of blood in the body. They thus find an application in the angiography field. On the other hand, they do not make it possible to detect a particular static or virtually static element of the body. They cannot therefore be used as a basis for the formation of an image for a particular organ or for a particular cell type.
- A third method has made a name for itself in the last few years in the angiography field. It comprises a step consisting in injecting a contrast product into a body. In general, the contrast product used is gadolinium attached to a chelating agent such as DOTA (or tetraazacyclododecane tetraacetate) or DTPA (or diethylenetriamine pentaacetate). The chelating agent is a molecular cage that surrounds the gadolinium and makes it possible to limit its toxicity with respect to the body into which it is injected. The effect of this product is to decrease the relaxation time of the protons that are in proximity. Specifically, the contrast product contains single unpaired electrons which have a paramagnetic effect that acts on the water protons.
- This increase in proton relaxation makes it possible to limit the saturation in the zone where the injected product is located. The resulting magnetic resonance signal is therefore greatly increased. Conversely, the protons that are not in immediate proximity to the gadolinium keep an unchanged relaxation time and therefore generate a lower magnetic resonance signal.
- Initially after injection, the contrast product moves in the blood vessels without being absorbed by the surrounding tissues. Detection of the magnetic resonance signals therefore makes it possible to distinguish between the blood vessels and the surrounding tissues and also to form an image revealing this distinction.
- However, this technique also has drawbacks. In particular, paramagnetic gadolinium, in addition to its action on proton relaxation time, creates magnetic induction microgradients that result in local distortions of the magnetic induction to which the body is subjected. The frequencies of the waves transmitted are dispersed. This effect can result in the loss of certain signals. When the magnetic resonance signals are used to form an image of a zone of the body in question, said image will therefore be difficult to interpret. This results in the spatial resolution of the images obtained by this technique being limited: this method does not allow complete suppression of the signals derived from tissues lacking contrast product.
- An object of the present invention is to provide a method for acquiring magnetic resonance signals that limits the problems encountered in the above techniques.
- Another object of the invention is to enable acquisition of the signals from a selected observed zone, independent of its type. For example, the observed zone may contain substantially mobile or substantially immobile protons. It may be a blood vessel or a vascularized network, but also an organ, a group of cells, or the like.
- The invention thus proposes a method for acquiring electromagnetic signals received from at least one part of a body placed in a system comprising means for generating a magnetic induction B0, said magnetic induction comprising gradients in certain directions in space, means for transmitting radio frequency wave pulse sequences perpendicular to the magnetic induction B0 in a range of adjustable frequencies, and means for detecting electromagnetic signals received from said body part. The method comprises the following steps:
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- a) injecting, into said body part, an amount of contrast product capable of being temporarily fixed in or of passing through an observed zone of said body part, said contrast product comprising at least one element capable of causing a chemical shift of a resonance frequency of water hydrogen protons;
- b) exciting said body part by means of a radio frequency wave pulse sequence in a range of frequencies adjusted according to the magnetic induction B0 and to the chemical shift for at least some of said radio frequency waves;
- c) detecting, coherently with the excitation of step b), electromagnetic signals received from said body part, said signals corresponding substantially to magnetic resonance signals of the protons of the observed zone having undergone the chemical shift.
- The chemical shift provided by the contrast product brings about a shift in the resonance frequency of the hydrogen protons contained in the water in proximity to the injected contrast product. This shift in frequency makes it possible to obtain a selective signal from the protons chemically shifted during a radio frequency-based solicitation taking into account this shift. Such selective signal can advantageously be used as a basis for forming an image.
- The observed zone envisioned here may be of various types, for instance a blood vessel, a group of cells expressing a gene, a tumor zone, or the like.
- The invention also proposes a contrast product intended to be injected into at least one part of a body for the purpose of acquiring electromagnetic signals from said body part. This product comprises at least one element capable of causing a chemical shift of a resonance frequency of water hydrogen protons.
- The element included in the contrast product may advantageously be a lanthanide, for example dysprosium, praseodymium and/or europium, optionally attached to a chelating agent, or any other element capable of inducing a modification of the resonance frequency.
- Other particularities and advantages of the present invention will emerge from the following description of nonlimiting implementation examples, with reference to the attached drawing in which the single FIGURE is a simplified representation of an observed zone to which the invention is applied.
- According to the invention, an amount of contrast product is injected into a body 4, which may be, for example, a human or animal body, but which may also be an inert body. The injection is performed in such a way that the contrast product is fixed at least temporarily in or passes through an observed zone 1. In the case of a human body, for example, the contrast product may be injected intravenously. The observed zone may then comprise a
blood vessel 2 through which the contrast product passes, and also the tissues 3 that surround this vessel. - The various steps of the method described below must take place rapidly after injection of the contrast product so that the latter remains essentially contained in the zone for which it is desired to recover a magnetic resonance signal, i.e., in the example illustrated in the FIGURE, the
vessel 2, but not the tissues 3 that surround it. - The contrast product used according to the invention has the property of effecting a chemical shift on the hydrogen protons that are in proximity thereto. This is because such a product contains atoms whose electron cloud is capable of modifying the local magnetic induction experienced by the nucleus observed. The protons that are in proximity to the contrast product, for example the protons contained in the hydrogen of the water of the blood circulating in the
vessel 2, are subjected to this magnetic induction. - If the protons in contact with the contrast product are subjected to a magnetic induction B0, their resonance frequency is no longer the Larmor frequency v0 proportional to the amplitude of B0, but a frequency v1 that is shifted with respect to v0. By way of illustration, if the chemical shift created by the contact product is 3.5 parts per million (ppm), the following frequency relationship is obtained: v1−v0=3.5×10−6×v0. For a magnetic induction B0=1.5 T, the Larmor frequency v0=63 MHz, and a frequency shift v1−v0≈220 Hz is therefore obtained between the protons that are in proximity to or not in proximity to the contrast product.
- It should be noted that the chemical shift property is not inherent to all products. In particular, gadolinium, commonly used as a contrast agent for its properties of reducing the proton relaxation time as explained in the introduction, causes virtually no chemical shift. On the other hand, three other elements of the lanthanide family are notable for their chemical shift action. These are dysprosium (Dy), praseodymium (Pr) and europium (Eu).
- For example, as regards dysprosium, the chemical shift created Δ (in ppm) is proportional to the concentration of dysprosium (in millimoles per liter) with a proportionality coefficient of 0.185, i.e. Δ=0.185*[Dy].
- Conventionally, cages are used to surround the lanthanides in order to limit their toxicity, as was the case for gadolinium. These cages are typically chelating agents such as DOTA or DTPA. The contrast product used is therefore advantageously a lanthanide chelate capable of generating a chemical shift, such as Dy-DOTA, Dy-DTPA, Pr-DOTA or Pr-DTPA.
- The body 4 is placed, immediately before or after injection of the contrast product, in a system that surrounds a part of the body and that is capable of generating a high-amplitude magnetic induction B0. This induction comprises gradients in principle directions in space according to the type of information that it is desired to acquire. For example, if it is desired to obtain magnetic resonance signals for elementary volumes in three-dimensional space, it will be advisable to introduce coding gradients Gx, Gy and Gz for the magnetic induction B0 in three main perpendicular directions (x, y, z) in space, in a manner known in itself. By means of this technique, magnetic induction values that are different between elementary volumes of the body 4 are ensured.
- The system in which the body 4 is placed also has a transmitter of radio frequency wave pulse sequences in a range of adjustable frequencies that may be more or less selective, according to the duration of transmission of the corresponding waves. These RF waves are transmitted perpendicular to the direction of the magnetic induction B0. When a wave is transmitted at a frequency corresponding to the proton resonance frequency, said protons are then taken out of their equilibrium position in a direction close to that of the induction B0, and then they gradually return to this equilibrium position.
- According to the invention, the protons in proximity to the injected contrast product have a resonance frequency that is shifted with respect to the usual Larmor frequency. Advantage is then taken of this particularity in order to recover electromagnetic signals only from these chemically shifted protons.
- For this, at least two methods can be envisioned. According to a first embodiment, a radio frequency wave pulse sequence is transmitted with a frequency adjusted selectively to the value of the frequency shifted due to the chemical shift, i.e. v1 according to the notation employed above.
- At the end of each transmission of a radio frequency wave pulse sequence, a reception module detects and evaluates the transmitted magnetic resonance signal. According to the principle explained above, only the protons in the
vessel 2 of the example illustrated in the FIGURE come into resonance and generate a magnetic resonance signal. The other protons that are not in proximity to the injected contrast product, i.e. typically the protons present in the tissues 3, generate virtually no signal. - Thus, if an image of the observed zone 1 is realized, for example in a spatial plane, by taking advantage of the magnetic induction gradients, and with each point of the image corresponding substantially to a detected signal value, as a function of its geographical position in the plane under consideration according to a conventional spatial coding, the zones where the contrast product has been fixed can be clearly distinguished. An image is thus obtained, where the
vessel 2 will be visible, while the tissues 3 will be invisible. - This embodiment is therefore entirely advantageous. However, it has the drawback of requiring a sequence of radio frequency transmissions that are selective with respect to frequency, which means that a considerable transmission time is needed. When the observed zone is large, the signal acquisition time may prove to be disadvantageous.
- A second advantageous embodiment makes it possible to limit the magnetic resonance signal acquisition time. It consists in using a radio frequency wave pulse transmission sequence comprising a first series of selective wave pulses adjusted to a frequency corresponding substantially to the Larmor frequency for the water protons not chemically shifted, i.e. the protons of the tissues 3 in the example illustrated. These waves are transmitted with a sufficient duration to saturate the protons concerned, to such an extent that these protons no longer transmit any significant magnetic resonance signal at the end of the first series of wave pulses.
- The radio frequency wave transmission sequence also comprises a second series of wave pulses that are relatively nonselective in terms of frequency, each wave of the sequence being transmitted over a short period of time. The range of frequencies covered by these waves comprises the resonance frequency of the chemically shifted protons, i.e. of the protons of the
vessel 2. Thus, only the latter protons will come into resonance upon transmission of the second series of waves, the protons of the tissues 3 being saturated. This makes it possible to rapidly receive the signals coming from only the protons of thevessel 2. - In this way, the signals transmitted by the chemically shifted protons are isolated with precision. Furthermore, the contrast products used with dysprosium, praseodymium or europium have only a limited action on the distortion of the magnetic induction in the observed zone, through the creation of magnetic induction microgradients, unlike gadolinium. The images obtained by applying this technique therefore potentially have a greater spatial resolution than the known techniques using gadolinium chelates.
- As was described above, the chemical shift engendered by injection of the contrast product, for example dysprosium, as a function of the concentration of the latter, is known. This prior knowledge can make it possible to precisely select the frequency of the wave to be transmitted in the observed zone. However, in another advantageous embodiment, it is possible to determine the frequency resulting from the chemical shift without prior knowledge. For this, the observed zone 1 of the body 4 is subjected to successive waves in a broad spectrum of radiofrequencies and the magnetic resonance signals generated by the observed zone in reaction to each of these waves are detected. The main frequency that causes the protons of the observed zone having undergone the chemical shift to come into resonance is then deduced therefrom.
- So far, the observed zone 1, illustrated in the FIGURE, has been taken to comprise a
blood vessel 2 surrounded by tissues 3. This representation makes it possible to envision applications of the present invention in the angiography field. - However, the invention can also be applied to other types of observed zones. In particular, the observed zone may comprise a target, which may, for example, be a cell, a molecule, a protein, or a group of targets of the body under consideration, such as a group of cells expressing a gene.
- In this situation, a known targeting molecule is advantageously attached to the contrast product injected into the body, such that the latter is temporarily fixed in the target. The steps described above can then be carried out so as to acquire magnetic resonance signals coming from the target only, with the exclusion of certain surrounding tissues in which the contrast product has not been fixed. This embodiment is particularly advantageous and finds applications in the field of cellular and molecular imaging, for example for studying gene expression in vivo, for localizing a particularly biological activity, or the like.
- The observed zone may also be a zone of angiogenesis, for example a tumor zone. Such a zone generally comprises a vascularized network, the vascularization index of which gives an indication regarding the malignant or benign nature of the tumor.
- In one embodiment, the invention makes it possible to determine such a vascularization index. To this effect, the lanthanide chelate used as contrast product is injected so as to be temporarily fixed in the tumor zone. As described above, it is possible to realize a spectrum in this observed zone, i.e. to transmit successive radio frequency waves within a broad spectrum of frequencies. The resonance frequency of the protons located in the vascularized network present in the tumor zone is deduced therefrom, this resonance frequency being substantially the frequency for which magnetic resonance signals were received (outside the conventional Larmor frequency of the water protons not having experienced a chemical shift). Advantageously, this operation can be carried out several times at successive moments so as to make it possible to monitor any change in the time of this resonance frequency.
- As was indicated above, the chemical shift caused by the contrast product, for example based on dysprosium, is proportional to the concentration of dysprosium. Determination of the resonance frequency in the tumor zone, which is itself proportional to the chemical shift, then gives an indication of the concentration of contrast product fixed in the observed zone. It is therefore understood that this indication constitutes a vascularization index that can be taken into account in a subsequent analysis of the tumor.
- As in the previous cases, the magnetic resonance signals coming from the tumor zone can be acquired so as to characterize in greater detail the vascularized network present in the tumor zone. An image of the zone can also be obtained from this acquisition.
Claims (15)
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FR0215826A FR2848750B1 (en) | 2002-12-13 | 2002-12-13 | METHOD FOR ACQUIRING ELECTROMAGNETIC SIGNALS AND CONTRAST PRODUCT FOR SUCH ACQUISITION |
PCT/FR2003/003628 WO2004062498A1 (en) | 2002-12-13 | 2003-12-08 | Method for acquiring electromagnetic signals and contrast product therefor |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080097185A1 (en) * | 2006-10-18 | 2008-04-24 | Cardiospectra, Inc. | Hemoglobin contrast in ultrasound and optical coherence tomography for diagnosing diseased tissue, cancers, and the like |
US20080097194A1 (en) * | 2006-10-18 | 2008-04-24 | Milner Thomas E | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US20100201361A1 (en) * | 2007-05-03 | 2010-08-12 | Edelman Robert R | System and method for passive catheter tracking with magnetic resonance imaging |
US9028470B2 (en) | 2011-06-17 | 2015-05-12 | University Of Utah Research Foundation | Image-guided renal nerve ablation |
US9198596B2 (en) | 2005-05-27 | 2015-12-01 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI667487B (en) | 2016-09-29 | 2019-08-01 | 美商超精細研究股份有限公司 | Radio frequency coil tuning methods and apparatus |
Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4915933A (en) * | 1986-06-26 | 1990-04-10 | The University Of New Mexico | Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy |
US5399338A (en) * | 1991-05-01 | 1995-03-21 | University Of New Mexico | Enhancement of abnormal tissue uptake of antibodies, tumor-specific agents or conjugates thereof for diagnostic imaging or therapy |
US5458127A (en) * | 1991-09-24 | 1995-10-17 | Imarx Pharmaceutical Corp. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US5628982A (en) * | 1985-05-08 | 1997-05-13 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
US5681544A (en) * | 1988-02-29 | 1997-10-28 | Schering Aktiengesellschaft | Polymer-bonded complexing agents, their complexes and conjugates, processes for their production and pharmaceutical agents containing them |
US5738837A (en) * | 1990-04-02 | 1998-04-14 | Nycomed Imaging As | Lanthanide paramagnetic agents for magnetometric imaging |
US5861140A (en) * | 1996-11-20 | 1999-01-19 | Hoechst Celanese Corp. | Tripodal paramagnetic contrast agents for MR imaging |
US6232295B1 (en) * | 1994-10-12 | 2001-05-15 | Jon Faiz Kayyem | Cell-specific contrast agent and gene delivery vehicles |
US6253190B1 (en) * | 1995-04-28 | 2001-06-26 | Telxon Corporation | Programmable shelf tag and method for changing and updating shelf tag information |
US6269342B1 (en) * | 1995-04-28 | 2001-07-31 | Telxon Corporation | Programmable shelf tag system |
US20020197648A1 (en) * | 2001-05-02 | 2002-12-26 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
US20030064023A1 (en) * | 2001-09-20 | 2003-04-03 | Bastiaan Driehuys | Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe |
US20030064024A1 (en) * | 2001-09-20 | 2003-04-03 | Bastiaan Driehuys | Methods for in vivo evaluation of respiratory or cardiopulmonary disorders such as chronic heart failure using polarized 129Xe |
US6560477B1 (en) * | 2000-03-17 | 2003-05-06 | The Regents Of The University Of California | Joint imaging system utilizing magnetic resonance imaging and associated methods |
US20030103898A1 (en) * | 2001-08-08 | 2003-06-05 | Carpenter Alan P. | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
US6685915B2 (en) * | 1999-12-01 | 2004-02-03 | General Electric Company | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging |
US6713046B1 (en) * | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
US6715675B1 (en) * | 2000-11-16 | 2004-04-06 | Eldat Communication Ltd. | Electronic shelf label systems and methods |
US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1242643A (en) * | 1983-08-12 | 1988-10-04 | Eric T. Fossel | Nmr imaging utilizing chemical shift reagents |
IT1265440B1 (en) * | 1993-12-24 | 1996-11-22 | Bracco Spa | PARAMAGNETIC DIAGNOSTIC FORMULATIONS AND METHOD OF USE OF THEM |
-
2002
- 2002-12-13 FR FR0215826A patent/FR2848750B1/en not_active Expired - Fee Related
-
2003
- 2003-12-08 AU AU2003296781A patent/AU2003296781A1/en not_active Abandoned
- 2003-12-08 WO PCT/FR2003/003628 patent/WO2004062498A1/en not_active Application Discontinuation
- 2003-12-08 US US10/538,826 patent/US20060058642A1/en not_active Abandoned
-
2010
- 2010-07-06 US US12/831,194 patent/US8380282B2/en not_active Expired - Fee Related
Patent Citations (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5628982A (en) * | 1985-05-08 | 1997-05-13 | The General Hospital Corporation | Hydroxy-aryl metal chelates for diagnostic NMR imaging |
US4915933A (en) * | 1986-06-26 | 1990-04-10 | The University Of New Mexico | Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy |
US5681544A (en) * | 1988-02-29 | 1997-10-28 | Schering Aktiengesellschaft | Polymer-bonded complexing agents, their complexes and conjugates, processes for their production and pharmaceutical agents containing them |
US5738837A (en) * | 1990-04-02 | 1998-04-14 | Nycomed Imaging As | Lanthanide paramagnetic agents for magnetometric imaging |
US5399338A (en) * | 1991-05-01 | 1995-03-21 | University Of New Mexico | Enhancement of abnormal tissue uptake of antibodies, tumor-specific agents or conjugates thereof for diagnostic imaging or therapy |
US5458127A (en) * | 1991-09-24 | 1995-10-17 | Imarx Pharmaceutical Corp. | Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications |
US6232295B1 (en) * | 1994-10-12 | 2001-05-15 | Jon Faiz Kayyem | Cell-specific contrast agent and gene delivery vehicles |
US6253190B1 (en) * | 1995-04-28 | 2001-06-26 | Telxon Corporation | Programmable shelf tag and method for changing and updating shelf tag information |
US6269342B1 (en) * | 1995-04-28 | 2001-07-31 | Telxon Corporation | Programmable shelf tag system |
US6770261B2 (en) * | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
US5861140A (en) * | 1996-11-20 | 1999-01-19 | Hoechst Celanese Corp. | Tripodal paramagnetic contrast agents for MR imaging |
US6713046B1 (en) * | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
US6685915B2 (en) * | 1999-12-01 | 2004-02-03 | General Electric Company | Extended-linear polymeric contrast agents, and synthesizing methods, for medical imaging |
US6560477B1 (en) * | 2000-03-17 | 2003-05-06 | The Regents Of The University Of California | Joint imaging system utilizing magnetic resonance imaging and associated methods |
US6715675B1 (en) * | 2000-11-16 | 2004-04-06 | Eldat Communication Ltd. | Electronic shelf label systems and methods |
US20020197648A1 (en) * | 2001-05-02 | 2002-12-26 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
US20030103898A1 (en) * | 2001-08-08 | 2003-06-05 | Carpenter Alan P. | Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent |
US20030064023A1 (en) * | 2001-09-20 | 2003-04-03 | Bastiaan Driehuys | Methods for in vivo evaluation of physiological conditions and/or organ or system function including methods to evaluate cardiopulmonary disorders such as chronic heart failure using polarized 129 Xe |
US20030064024A1 (en) * | 2001-09-20 | 2003-04-03 | Bastiaan Driehuys | Methods for in vivo evaluation of respiratory or cardiopulmonary disorders such as chronic heart failure using polarized 129Xe |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9198596B2 (en) | 2005-05-27 | 2015-12-01 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US9687153B2 (en) | 2005-05-27 | 2017-06-27 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US20080097185A1 (en) * | 2006-10-18 | 2008-04-24 | Cardiospectra, Inc. | Hemoglobin contrast in ultrasound and optical coherence tomography for diagnosing diseased tissue, cancers, and the like |
US20080097194A1 (en) * | 2006-10-18 | 2008-04-24 | Milner Thomas E | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US8036732B2 (en) * | 2006-10-18 | 2011-10-11 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US8162834B2 (en) * | 2006-10-18 | 2012-04-24 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in ultrasound and optical coherence tomography for diagnosing diseased tissue, cancers, and the like |
US9204802B2 (en) | 2006-10-18 | 2015-12-08 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in ultrasound and optical coherence tomography for diagnosing diseased tissue, cancers, and the like |
US9215983B2 (en) | 2006-10-18 | 2015-12-22 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus |
US9532718B2 (en) | 2006-10-18 | 2017-01-03 | Board Of Regents, The University Of Texas System | Hemoglobin contrast in ultrasound and optical coherence tomography for diagnosing diseased tissue, cancers, and the like |
US20100201361A1 (en) * | 2007-05-03 | 2010-08-12 | Edelman Robert R | System and method for passive catheter tracking with magnetic resonance imaging |
US9028470B2 (en) | 2011-06-17 | 2015-05-12 | University Of Utah Research Foundation | Image-guided renal nerve ablation |
Also Published As
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WO2004062498A1 (en) | 2004-07-29 |
FR2848750A1 (en) | 2004-06-18 |
US8380282B2 (en) | 2013-02-19 |
AU2003296781A1 (en) | 2004-08-10 |
US20110144477A1 (en) | 2011-06-16 |
AU2003296781A8 (en) | 2004-08-10 |
FR2848750B1 (en) | 2007-02-09 |
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