US20060030881A1 - Ventricular partitioning device - Google Patents

Ventricular partitioning device Download PDF

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Publication number
US20060030881A1
US20060030881A1 US10/913,608 US91360804A US2006030881A1 US 20060030881 A1 US20060030881 A1 US 20060030881A1 US 91360804 A US91360804 A US 91360804A US 2006030881 A1 US2006030881 A1 US 2006030881A1
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United States
Prior art keywords
device
patient
partitioning
ribs
component
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Abandoned
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US10/913,608
Inventor
Hugh Sharkey
Alexander Khairkhkahan
Serjan Nikolic
Branislav Radovancevic
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Edwards Lifesciences Corp
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CardioKinetix Inc
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Priority to US10/913,608 priority Critical patent/US20060030881A1/en
Assigned to CARDIOKINETIX, INC. reassignment CARDIOKINETIX, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: RADOVANECEVIC, BRANISLAV, KHAIRKHAHAN, ALEXANDER, NIKOLIC, SERJIAN D., SHARKEY, HUGH R.
Publication of US20060030881A1 publication Critical patent/US20060030881A1/en
Assigned to CARDIOKINETIX, INC. reassignment CARDIOKINETIX, INC. RECORD TO CORRECT THE CONVEYING PARTIES NAMES, PREVIOUSLY RECORDED AT REEL 016049 FRAME 0473. Assignors: SHARKEY, HUGH R., KHAIRKHAHAN, ALEXANDER, NIKOLIC, SERJAN D., RADOVANCEVIC, BRANISLAV
Priority claimed from US12/893,832 external-priority patent/US9078660B2/en
Priority claimed from US13/828,184 external-priority patent/US9332993B2/en
Priority claimed from US13/827,927 external-priority patent/US9332992B2/en
Priority claimed from US15/133,080 external-priority patent/US10064696B2/en
Assigned to CARDIOKINETIX (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC reassignment CARDIOKINETIX (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CARDIOKINETIX, INC.
Assigned to EDWARDS LIFESCIENCES CORPORATION reassignment EDWARDS LIFESCIENCES CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CARDIOKINETIX (ASSIGNMENT FOR THE BENEFIT OF CREDITORS), LLC
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12131Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
    • A61B17/12168Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure
    • A61B17/12172Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a mesh structure having a pre-set deployed three-dimensional shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B17/12099Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
    • A61B17/12122Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder within the heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00526Methods of manufacturing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/12Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
    • A61B17/12022Occluding by internal devices, e.g. balloons or releasable wires
    • A61B2017/1205Introduction devices
    • A61B2017/12054Details concerning the detachment of the occluding device from the introduction device
    • A61B2017/12095Threaded connection

Abstract

This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a frame-reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber. The proximal ends of the ribs of the frame have tissue penetrating elements about the periphery thereof which are configured to penetrate tissue lining the heart wall at an angle approximately perpendicular to a longitudinal axis of the partitioning device. The partitioning device has a hub with a non-traumatic distal end to engage the ventricular wall.

Description

    FIELD OF THE INVENTION
  • The present invention relates generally to the field of treating congestive heart failure and more specifically, to a device and method for partitioning a patient's heart chamber and a system for delivering the treatment device.
  • BACKGROUND OF THE INVENTION
  • Congestive heart failure (CHF) is characterized by a progressive enlargement of the heart, particularly the left ventricle and is a major cause of death and disability in the United States. Approximately 500,000 cases occur annually in the U.S. alone. As the patient's heart enlarges, it cannot efficiently pump blood forward with each heart beat. In time, the heart becomes so enlarged the heart cannot adequately supply blood to the body. Even in healthy hearts only a certain percentage of the blood in a patient's left ventricle is pumped out or ejected from the chamber during each stroke of the heart. The pumped percentage, commonly referred to as the “ejection fraction”, is typically about sixty percent for a healthy heart. A patient with congestive heart failure can have an ejection fraction of less than 40% and sometimes lower. As a result of the low ejection fraction, a patient with congestive heart failure is fatigued, unable to perform even simple tasks requiring exertion and experiences pain and discomfort. Further, as the heart enlarges, the internal heart valves such as the mitral valve, cannot adequately close. An incompetent mitral valve allows regurgitation of blood from the left ventricle back into the left atrium, further reducing the heart's ability to pump blood forewardly.
  • Congestive heart failure can result from a variety of conditions, including viral infections, incompetent heart valves (e.g. mitral valve), ischemic conditions in the heart wall or a combination of these conditions. Prolonged ischemia and occlusion of coronary arteries can result in myocardial tissue in the ventricular wall dying and becoming scar tissue. Once the myocardial tissue dies, it is less contractile (sometimes non-contractile) and no longer contributes to the pumping action of the heart. It is referred to as hypokinetic. As the disease progresses, a local area of compromised myocardium may bulge out during the heart contractions, further decreasing the heart's ability to pump blood and further reducing the ejection fraction. In this instance, the heart wall is referred to as dyskinetic or akinetic. The dyskinetic region of the heart wall may stretch and eventually form an aneurysmic bulge.
  • Patients suffering from congestive heart failure are commonly grouped into four classes, Classes I, II, III and IV. In the early stages, Classes I and II, drug therapy is presently the most commonly prescribed treatment. Drug therapy typically treats the symptoms of the disease and may slow the progression of the disease, but it can not cure the disease. Presently, the only permanent treatment for congestive heart disease is heart transplantation, but heart transplant procedures are very risky, extremely invasive and expensive and are performed on a small percentage of patients. Many patient's do not qualify for heart transplant for failure to meet any one of a number of qualifying criteria, and, furthermore, there are not enough hearts available for transplant to meet the needs of CHF patients who do qualify.
  • Substantial effort has been made to find alternative treatments for congestive heart disease. For example, surgical procedures have been developed to dissect and remove weakened portions of the ventricular wall in order to reduce heart volume. This procedure is highly invasive, risky and expensive and is commonly only done in conjunction with other procedures (such as heart valve replacement or coronary artery by-pass graft). Additionally, the surgical treatment is usually limited to Class IV patients and, accordingly, is not an option for patients facing ineffective drug treatment prior to Class IV. Finally, if the procedure fails, emergency heart transplant is the only presently available option.
  • Other efforts to treat CHF include the use of an elastic support, such as an artificial elastic sock placed around the heart to prevent further deleterious remodeling.
  • Additionally, mechanical assist devices have been developed as intermediate procedures for treating congestive heart disease. Such devices include left ventricular assist devices and total artificial hearts. A left ventricular assist device includes a mechanical pump for increasing blood flow from the left ventricle into the aorta. Total artificial heart devices, such as the Jarvik heart, are usually used only as temporary measures while a patient awaits a donor heart for transplant.
  • Recently, improvements have been made in treating patient's with CHF by implanting pacing leads in both sides of the heart in order to coordinate the contraction of both ventricles of the heart. This technique has been shown to improve hemodynamic performance and can result in increased ejection fraction from the right ventricle to the patient's lungs and the ejection fraction from the left ventricle to the patient's aorta. While this procedure has been found to be successful in providing some relief from CHF symtoms and slowed the progression of the disease, it has not been able to stop the disease.
  • SUMMARY OF THE INVENTION
  • The present invention is directed to a ventricular partitioning device and method of employing the device in the treatment of a patient with congestive heart failure (CHF). Specifically, the device partitions a chamber of the patient's heart into a main productive portion and a secondary non-productive portion. This partitioning reduces the total volume of the heart chamber, reduces the stress applied to the heart and, as a result, improves the ejection fraction thereof.
  • A partitioning device embodying features of the invention has a reinforced partitioning component with a concave, pressure receiving surface which defines in part the main productive portion of the partitioned heart chamber when secured within the patient's heart chamber.
  • The reinforced partitioning component preferably includes a hub and a membrane forming the pressure receiving surface. The partitioning component is reinforced by a radially expandable frame component formed of a plurality of ribs.
  • The ribs of the expandable frame have distal ends secured to the central hub and free proximal ends. The distal ends are preferably secured to the central hub to facilitate radial self expansion of the free proximal ends of the ribs away from a centerline axis. The distal ends of the ribs may be pivotally mounted to the hub and biased outwardly or fixed to the hub and formed of material such as superelastic NiTi alloy which allows for compressing the free proximal ends of the ribs toward a centerline axis into a contracted configuration and when released allow for their self expansion to an expanded configuration.
  • The free proximal ends of the ribs are configured to engage and preferably penetrate the tissue lining the heart chamber to be partitioned so as to secure the peripheral edge of the partitioning component to the heart wall and fix the partitioning component within the chamber so as to partition the chamber in a desired manner. The tissue penetrating proximal tips are configured to penetrate the tissue lining at an angle approximately perpendicular to a center line axis of the partitioning device. The tissue penetrating proximal tips of the ribs may be provided with barbs, hooks and the like which prevent withdrawal from the tips from the heart wall.
  • The ribs in their expanded configuration angle outwardly from the hub and the free proximal ends curve outwardly so that the membrane secured to the ribs of the expanded frame forms a trumpet-shaped, pressure receiving surface.
  • The partitioning membrane in the expanded configuration has radial dimensions from about 10 to about 160 mm, preferably about 50 to about 100 mm, as measured from the center line axis.
  • The partitioning device may be delivered percutaneously or intraoperatively. One particularly suitable delivery catheter has an elongated shaft, a releasable securing device on the distal end of the shaft for holding the partitioning device on the distal end and an expandable member such as an inflatable balloon on a distal portion of the shaft proximal to the distal end to press the interior of the recess formed by the pressure receiving surface to ensure that the tissue penetrating tips or elements on the periphery of the partitioning device penetrate sufficiently into the heart wall to hold the partitioning device in a desired position to effectively partition the heart chamber.
  • The partitioning device embodying features of the invention is relatively easy to install and it substantially improves the pumping action of the heart and provides an increase in the ejection fraction of the patient's heart chamber. These and other advantages of the invention will become more apparent from the following detailed description of the invention and the accompanying exemplary drawings.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is an elevational view of a partitioning device embodying features of the invention in an expanded configuration.
  • FIG. 2 is a plan view of the partitioning device shown in FIG. 1.
  • FIG. 3 is a partial longitudinal cross-sectional view of the hub of the partitioning device shown in FIG. 1.
  • FIG. 4 is a transverse cross sectional view of the hub shown in FIG. 3 taken along the lines 4-4.
  • FIG. 5 is a schematic elevational view of a delivery system for the partitioning device shown in FIGS. 1 and 2.
  • FIG. 6 is a transverse cross-sectional view of the delivery system shown in FIG. 5 taken along the lines 6-6.
  • FIG. 7 is an elevational view, partially in section, of the hub shown in FIG. 3 secured to the helical coil of the delivery system shown in FIG. 5.
  • FIGS. 8A-8E are schematic views of a patient's left ventricular chamber illustrating the deployment of the partitioning device shown in FIGS. 1 and 2 with the delivery system shown in FIG. 5 to partition the heart chamber into a primary productive portion and a secondary, non-productive portion.
  • FIG. 9 is a partial schematic view of the expandable frame of the partitioning device shown in FIGS. 1 and 2 in an unrestricted configuration.
  • FIG. 10 is a top view of the expandable frame shown in FIG. 9.
  • FIGS. 11-13 are schematic illustrations of a method of forming the partitioning device shown in FIGS. 1 and 2 from the expandable frame shown in FIGS. 9 and 10.
  • DETAILED DESCRIPTION OF EMBODIMENTS OF THE INVENTION
  • FIGS. 1-4 illustrate a partitioning component 10 which embodies features of the invention and which includes a partitioning membrane 11, a hub 12, preferably centrally located on the partitioning device, and a radially expandable reinforcing frame 13 formed of a plurality of ribs 14. Preferably, the partitioning membrane 11 is secured to the proximal or pressure side of the frame 13 as shown in FIG. 1. The ribs 14 have distal ends 15 which are secured to the hub 12 and free proximal ends 16 which are configured to curve or flare away from a center line axis 17. Radial expansion of the free proximal ends 16 unfurls the membrane 11 secured to the frame 13 so that the membrane presents a relatively smooth, pressure receiving surface 18 which defines in part the productive portion of the patient's partitioned heart chamber.
  • As shown in more detail in FIGS. 3 and 4, the distal ends 15 of the ribs 14 are secured within the hub 12 and a transversely disposed connector bar 20 is secured within the hub which is configured to secure the hub 12 and thus the partitioning component 10 to a delivery system such as shown in FIG. 5 and 6. The curved free proximal ends 16 of ribs 14 are provided with sharp tip elements 21 which are configured to hold the frame 13 and the membrane 11 secured thereto in a deployed position within the patient's heart chamber. Preferably, the sharp tip elements 21 of the frame 13 penetrate into tissue of the patient's heart wall in order to secure the partitioning component 10 within the heart chamber so as to partition the ventricular chamber into a productive portion and a non-productive portion.
  • The connector bar 20 of the hub 12, as will be described later, allows the partitioning device 10 to be secured to a delivery system delivery and to be released from the delivery system within the patient's heart chamber. The distal ends 15 of the reinforcing ribs 14 are secured within the hub 12 in a suitable manner or they may be secured to the surface defining the inner lumen or they may be disposed within channels or bores in the wall of the hub 12. The ribs 14 are preshaped so that when not constrained other than by the membrane 11 secured thereto (as shown in FIGS. 1 and 2), the free proximal ends 16 thereof expand to a desired angular displacement away from a center line axis 17 which is about 20° to about 90°, preferably about 50° to about 80°.
  • FIGS. 5-7 illustrate a suitable delivery system 30 delivering the partitioning component 10 shown in FIGS. 1 and 2 into a patient's heart chamber and deploying the partitioning component 10 to partition the heart chamber as shown in FIGS. 8A-8E. The delivery system 30 includes a guide catheter 31 and a delivery catheter 32.
  • The guide catheter has an inner lumen 33 extending between the proximal end 34 and distal end 35. A hemostatic valve (not shown) may be provided at the proximal end 34 of the guide catheter 31. A flush port 36 on the proximal end 34 of guide catheter 31 is in fluid communication with the inner lumen 33.
  • The delivery catheter 32 has an outer shaft 40 with an inner lumen 41 and a proximal injection port 42, an inner shaft 43 disposed within the inner lumen 41 with a first lumen 44 and a second lumen 45. Balloon inflation port 46 is in fluid communication with the first lumen 44 and flush port 47 is in fluid communication with the second lumen 45. Torque shaft 48 is rotatably disposed within the second lumen 44 of the inner shaft 43 and has an injection port 49 provided at its proximal end 50 in fluid communication with the inner lumen 51 of the torque shaft. The torque shaft 48 is preferably formed at least in part of a hypotube formed of suitable material such as superelastic NITINOL or stainless steel. A torque knob 52 is secured to the proximal end 50 of torque shaft 48 distal to the injection port 49. A helical coil screw 53 is secured to the distal end 54 of the torque shaft 48 and rotation of the torque knob 52 on the proximal end 50 of the torque shaft 48 rotates the screw 53 on the distal end 54 of torque shaft 48 to facilitate deployment of a partitioning device 10. A inflatable balloon 55 is sealingly secured to the distal end of the inner shaft 43 and has an interior 56 in fluid communication with the first lumen 44. Inflation fluid may be delivered to the interior 56 through port 44 a in the portion of the inner shaft 43 extending through the balloon 55. Inflation of the balloon 55 by inflation fluid through port 57 facilitates securing the partitioning component 10.
  • To deliver the partitioning component 10, it is secured to the distal end of the delivery catheter 32 by means of the helical coil screw 53. The partitioning component 10 is collapsed to a first, delivery configuration which has small enough transverse dimensions to be slidably advanced through the inner lumen 33 of the guide catheter 31. Preferably, the guide catheter 31 has been previously percutaneously introduced and advanced through the patient's vasculature, such as the femoral artery, in a conventional manner to the desired heart chamber. The delivery catheter 32 with the partitioning component 10 attached is advanced through the inner lumen 33 of the guide catheter 31 until the partitioning component 10 is ready for deployment from the distal end of the guide catheter 31 into the patient's heart chamber 58 to be partitioned.
  • The partitioning component 10 mounted on the screw 53 is urged partially out of the inner lumen 33 of the guide catheter 31 until the hub 12 engages the heart wall as shown in FIG. 8B with the free proximal ends 16 of the ribs 14 in a contracted configuration within the guide catheter. The guiding catheter 31 is withdrawn while the delivery catheter 32 is held in place until the proximal ends 16 of the ribs 14 exit the distal end 35 of the guiding catheter. The free proximal ends 16 of ribs 14 expand outwardly to press the sharp proximal tips 21 of the ribs 14 against and preferably into the tissue lining the heart chamber. This is shown in FIG. 8C.
  • With the partitioning component deployed within the heart chamber and preferably partially secured therein, inflation fluid is introduced through the inflation port 46 into first lumen 44 of inner shaft 43 of the delivery catheter 32 where it is directed through port 44 a into the balloon interior 56 to inflate the balloon. The inflated balloon presses against the pressure receiving surface 18 of the partitioning component 10 to ensure that the sharp proximal tips 21 are pressed well into the tissue lining the heart chamber.
  • With the partitioning device 10 properly positioned within the heart chamber, the knob 52 on the torque shaft 48 is rotated counter-clockwise to disengage the helical coil screw 53 of the delivery catheter 32 from the hub 12. The counter-clockwise rotation of the torque shaft 48 rotates the helical coil screw 53 which rides on the connector bar 20 secured within the hub 12. Once the helical coil screw 53 disengages the connector bar 20, the delivery system 30, including the guide catheter 31 and the delivery catheter 32, may then be removed from the patient.
  • The proximal end of the guide catheter 31 is provided with an flush port 36 to inject therapeutic or diagnostic fluids through the inner lumen 33. Similarly, the proximal end of the delivery catheter 32 is provided with a flush port 42 in communication with inner lumen 41 for essentially the same purpose. An inflation port 46 is provided on the proximal portion of the delivery catheter for delivery of inflation fluid through the first inner lumen 44 to the interior 56 of the balloon 55. Flush port 47 is provided in fluid communication with the second inner lumen 45 of the inner shaft 43. An injection port 49 is provided on the proximal end of the torque shaft 48 in fluid communication with the inner lumen 51 of the torque shaft for delivery of a variety of fluids.
  • The partitioning component 10 partitions the patient's heart chamber 57 into a main productive or operational portion 58 and a secondary, essentially non-productive portion 59. The operational portion 58 is much smaller than the original ventricular chamber 57 and provides for an improved ejection fraction. The partitioning increases the ejection fraction and provides an improvement in blood flow. Over time, the non-productive portion 59 fills first with thrombus and subsequently with cellular growth. Bio-resorbable fillers such as polylactic acid, polyglycolic acid, polycaprolactone and copolymers and blends may be employed to initially fill the non-productive portion 59. Fillers may be suitably supplied in a suitable solvent such as DMSO. Other materials which accelerate tissue growth or thrombus may be deployed in the non-productive portion 59.
  • FIGS. 9 and 10 illustrate the reinforcing frame 13 in an unstressed configuration and includes the ribs 14 and the hub 12. The ribs 14 have a length L of about 1 to about 8 cm, preferably, about 1.5 to about 4 cm for most left ventricle deployments. The proximal ends 16 have a flared construction. To assist in properly locating the device during advancement and placement thereof into a patient's heart chamber, parts, e.g. the distal extremity, of one or more of the ribs and/or the hub may be provided with markers at desirable locations that provide enhanced visualization by eye, by ultrasound, by X-ray, or other imaging or visualization means. Radiopaque markers may be made with, for example, stainless steel, platinum, gold, iridium, tantalum, tungsten, silver, rhodium, nickel, bismuth, other radiopaque metals, alloys and oxides of these metals.
  • The partitioning device 10 is conveniently formed by placing a thermoplastic tube 60, e.g. polyethylene, over the ribs 14 of the frame 13 as shown in FIG. 11 until the proximal ends 16 of the ribs 14 extend out the ends of the thermoplastic tubes as shown in FIG. 12. A first expanded PTFE sheet 61 of appropriate size is placed in the female platen 62 of the press 63. The frame 13 with tubes 60 slidably disposed over the ribs 14 is placed in platen 62 on top of the ePTFE sheet 61. The center portion of the sheet 61 may be provided with an opening through which the hub 12 extends. A second ePTFE sheet 64 is placed on top of the ribs 14 of frame 13 as shown in FIG. 13. The male platen 65 is heated, preferably to about 500° F., so that the thermoplastic tubes 60 disposed over the ribs 14 fuse into the porous matrix of the ePTFE sheets 61 and 64. The fused thermoplastic material solidifies and secures the sheets 61 and 64 to the ribs 14 and prevents their delamination during use.
  • While porous ePTFE material is preferred, the membrane 11 may be formed of suitable biocompatitble polymeric material which include Nylon, PET (polyethylene terephthalate) and polyesters such as Hytrel. The membrane 11 is preferably foraminous in nature to facilitate tissue ingrowth after deployment within the patient's heart. The delivery catheter 32 and the guiding catheter 31 may be formed of suitable high strength polymeric material such as PEEK (polyetheretherketone), polycarbonate, PET, Nylon, and the like. Braided composite shafts may also be employed.
  • To the extent not otherwise described herein, the various components of the partitioning device and delivery system may be formed of conventional materials and in a conventional manner as will be appreciated by those skilled in the art.
  • While particular forms of the invention have been illustrated and described herein, it will be apparent that various modifications and improvements can be made to the invention. Moreover, individual features of embodiments of the invention may be shown in some drawings and not in others, but those skilled in the art will recognize that individual features of one embodiment of the invention can be combined with any or all the features of another embodiment. Accordingly, it is not intended that the invention be limited to the specific embodiments illustrated. It is intended that this invention to be defined by the scope of the appended claims as broadly as the prior art will permit.
  • Terms such a “element”, “member”, “device”, “section”, “portion”, “step”, “means” and words of similar import, when used herein shall not be construed as invoking the provisions of 35 U.S.C. §112(6) unless the following claims expressly use the terms “means” followed by a particular function without specific structure or “step” followed by a particular function without specific action. Accordingly, it is not intended that the invention be limited, except as by the appended claims. All patents and patent applications referred to above are hereby incorporated by reference in their entirety.

Claims (54)

1. A device for treating a patient with congestive heart failure by partitioning a chamber of the patient's heart into a primary productive portion and a secondary non-productive portion, comprising:
a. a partitioning component which has an expandable frame formed of a plurality of ribs having distal ends secured to a central hub and free outwardly flared proximal ends and which has a proximal, pressure receiving face forming a recess in an expanded, deployed configuration defining in part the primary productive portion of the patient's heart chamber to be partitioned; and
b. a plurality of tissue penetrating securing elements disposed at free ends of the ribs configured to penetrate tissue lining the heart chamber at an angle essentially perpendicular to the center line axis of the partitioning device to secure the periphery of the partitioning device to the heart chamber.
2. The device of claim 1 wherein reinforced partitioning component has a contracted configuration for delivery to patient's heart chamber to be partitioned.
3. The device of claim 1 wherein the pressure receiving surface of the partitioning component is formed at least in part of a membrane.
4. The device of claim 3 wherein the membrane is foraminous.
5. The device of claim 3 wherein the membrane is formed at least in part of a polymeric fabric.
6. The device of claim 5 wherein the polymeric fabric of the membrane is secured to the ribs by polymeric material fused in the polymeric fabric.
7. The device of claim 6 wherein the distal ends of the ribs are configured to facilitate abduction of the free proximal ends of the ribs away from a centerline axis to facilitate expansion of the reinforced partitioning component.
8. The device of claim 6 wherein the free proximal ends of the ribs are outwardly curved.
9. The device of claim 8 wherein the free proximal ends of the ribs have tips which penetrate the tissue lining the heart chamber at an angle of not more than 30° away from a line perpendicular to the center line axis of the partitioning device.
10. The device of claim 1 wherein the pressure receiving surface has radial dimensions from a center line axis of about 10 to about 160 mm.
11. The device of claim 1 wherein the pressure receiving surface has radial dimensions from a center line axis of about 5 to about 80 mm.
12. The device of claim 1 wherein the frame has about 3 to about 30 ribs.
13. The device of claim 1 wherein the frame has about 6 to about 16 ribs.
14. The device of claim 1 wherein the expandable frame is self expanding.
15. The device of claim 1 wherein the frame is formed of superelastic NiTi, alloy which is in an austenite phase when unstressed.
16. The device of claim 1 wherein the frame is in a stress maintained martensite phase when delivered through the patient's vasculature to the patient's heart chamber.
17. The device of claim 3 wherein the membrane is formed at least in part of expanded fluoropolymer.
18. The device of claim 17 wherein the expanded fluoropolymer is polytetrafluoroethylene.
19. A partitioning apparatus for a patients heart chamber to Improve cardiac ejection fraction, comprising:
a. a central hub component;
b. an expandable frame component having a plurality of ribs with free, outwardly flared proximal ends and distal ends secured to the central hub component;
c. a membrane component secured to the expandable frame ribs which defines a recessed, pressure receiving surface; and
d. tissue penetrating tips on a plurality of free, outwardly flared proximal ends which are configured to penetrate tissue lining the heart chamber to be partitioned at an angle essentially perpendicular to a center line axis of the partitioning device.
20. The partitioning apparatus of claim 30 wherein the hub has a non-traumatic distal tip to engage the region of the patients ventricular wall.
21. The partitioning apparatus of claim 30 wherein the non-traumatic distal tip has a bullet shape.
22. The partitioning apparatus of claim 30 wherein the membrane component is secured to the proximal side of the ribs.
23. The partitioning apparatus of claim 30 wherein the membrane component is secured to the distal side of the ribs.
24. An intracorporeal delivery catheter for a ventricular partitioning device for treating a patient with CHF, comprising:
a. an elongated shaft which has proximal and distal ends, a port proximal to the distal end and an inner lumen In fluid communication with the port;
b. a releasable securing element on the distal end of the elongated shaft configured to secure and release a ventricular partitioning device; and
c. an inflatable member on a distal portion of the elongated shaft having an interior in fluid communication with the inner lumen in the elongated shaft through the port therein which Is configured to expand a reinforced membrane of the partitioning device.
25. The intracorporeal delivery catheter of claim 24 wherein the elongated shaft has an outer shaft member with an inner lumen and an inner shaft member disposed within the inner lumen of the outer shaft, which has proximal and distal end, which has a first inner lumen extending within the inner shaft to the port proximal to the distal end of the inner shaft member to provide inflation fluid to the interior of the inflatable member, which has a second port in the distal end thereof and a second inner lumen extending within the inner shaft to the port in the distal end thereof.
26. The intracorporeal delivery catheter of claim 25 including a torque shaft which has proximal and distal ends, which is rotatably disposed within the second inner lumen of the inner shaft member and which has the releasable securing element on the distal end thereof for securing and releasing a ventricular partitioning device.
27. The intracorporeal delivery catheter of claim 26 wherein the releasable securing element on the distal end of the torque shaft is a helical screw connection element.
28. The intracorporeal delivery catheter of claim 27 wherein the helical screw connection element on the distal end of the torque shaft is configured to engage a connector bar on the partitioning device.
29. An intracorporeal delivery catheter for a ventricular partitioning device for treating a patient with CHF, comprising:
a. an elongated outer shaft with an inner lumen;
b. an inner shaft which is disposed within the inner lumen of the outer shaft, which has a first inner lumen extending within the inner shaft to a port proximal to the distal end thereof, which has a second inner lumen extending within the inner shaft to the distal end thereof; a balloon mounted on a distal portion of the inner shaft having an interior in fluid communication with the first inner lumen through the port;
c. a torque shaft which has proximal and distal ends, which is rotatably disposed within the second inner lumen of the inner shaft, which has a screw connection element on the distal end thereof extending out of the distal end of the inner shaft and configured to receive a partitioning device; and
d. an inflation port in fluid communication with the first inner lumen of the inner shaft for delivery of inflation fluid therethrough to the interior of the balloon.
30. An Intracorporeal partitioning component comprising:
a. a frame having a plurality of ribs with radially extending proximal ends and with distal ends secured to a hub; and
b. at least one porous sheet material secured to the ribs of the frame by fused thermoplastic material within the porous sheet material.
31. The intracorporeal partitioning component of claim 30 wherein at least one porous sheet is secured to the upper portion of the ribs of the frame and at least one sheet is secured to the lower portion of the ribs of the frame by thermoplastic material within the porous sheets.
32. A method of securing a porous polymeric sheet material to rib components of a frame structure, comprising:
a. sliding a thermoplastic tube over one or more rib components of the frame;
b. applying a porous sheet to the ribs covered with the thermoplastic polymeric tubes to form an assembly; and
c. heating the assembly to fuse the polymeric material of the thermoplastic tubes within the porous sheet.
33. The method of claim 32 wherein a porous sheet is applied to the upper surface of the frame.
34. The method of claim 32 wherein a porous sheet is applied to the lower surface of the frame.
35. The method of claim 32 wherein a first porous sheet is applied to the upper surface of the frame and a second porous sheet is applied to the lower surface of the frame.
36. The method of claim 35 wherein the assembly is placed onto a receiving platen of a press and a hot pressing platen is pressed against the assembly to fuse the thermoplastic polymeric material on the ribs of the frame within one or both of the porous membranes.
37. A method of treating a patient with congestive heart failure by partitioning the patient's heart chamber, comprising:
a. providing a reinforced membrane having a first contracted configuration for delivery to the patient's heart chamber and a second expanded configuration for deployment within the patient's heart chamber;
b. advancing the reinforced membrane in the first contracted configuration into the chamber of the patient's heart;
c. inflating an inflatable member disposed within the membrane to expand the reinforced membrane to the second expanded configuration to facilitate securing the reinforced membrane within the patient's heart chamber to partition the chamber into a primary productive portion and a secondary non-productive portion.
38. The method of claim 37 wherein the reinforced membrane is advanced into the patient's heart chamber through an inner lumen of a delivery catheter.
39. The method of claim 38 wherein the inflatable member is positioned on a distal portion of the delivery catheter.
40. The method of claim 37 wherein the expanding inflatable member secures a peripheral edge of the reinforced membrane to a wall defining at least in part the patients heart chamber.
41. The method of claim 37 wherein a central portion of the expanded reinforced membrane is spaced from a wall defining in part the patients heart chamber.
42. The method of claim 38 wherein the reinforced membrane is positioned within an inner lumen of the delivery catheter in the first contracted configuration, and advanced therein to a discharge port in the distal end of the delivery catheter and discharged from the discharge port into the patient's heart chamber where the contracted reinforced membrane expands to the second expanded configuration due at least in part to the expanding inflatable member.
43. The method of claim 38 wherein the delivery catheter is percutaneously introduced into the patient's vasculature and advanced therein until the distal end of the delivery catheter is disposed within the patients heart chamber.
44. The method of claim 40 wherein the edge of the reinforced membrane is secured to a wall defining at least in part the heart chamber by anchoring elements provided on the edge of the reinforced membrane.
45. The method of claim 37 wherein the reinforced membrane is in part self expanding.
46. A method of treating a patient with congestive heart failure, comprising:
a. providing an expandable reinforced membrane having a periphery with a plurality of anchoring elements thereon;
b. advancing the reinforced membrane in a contracted configuration within the patients vasculature until the reinforced member is disposed within a chamber of the patient's heart; and
c. inflating a balloon within the contracted reinforced membranes to expand the reinforced membrane into an expanded configuration within the heart chamber to secure the periphery of the reinforced membrane to the heart wall by the anchoring elements on the periphery of the reinforced membrane.
47. A method of treating a patient with congestive heart failure, comprising the steps of:
a. providing an expandable reinforced membrane having a periphery with a plurality of anchoring elements thereon;
b. advancing the reinforced membrane in a contracted configuration within the patient's vasculature until the reinforced member is disposed within a chamber of the patient's heart; and
c. inflating a balloon within the contracted reinforced membranes to expand the reinforced membrane into an expanded configuration within the heart chamber to secure the periphery of the reinforced membrane to the heart wall by the anchoring elements on the periphery of the reinforced membrane.
48. An intracorporeal product comprising:
a. a first component configured for intracorporeal deployment; and
b. at least one sheet of ePTFE material secured to the first component by fused thermoplastic material therebetween.
49. The intracorporeal product of claim 30 wherein a second ePTFE sheet is secured to the first component by thermoplastic material within the porous sheets.
50. A method of making an intracorporeal product securing a porous polymeric sheet material to rib components of a frame structure, comprising:
a. providing a ePTFE sheet;
b. providing an intracorporeal component;
c. deploying a thermoplastic element over at least part of the intracorporeal component;
d. applying the ePTFE sheet to at least a portion of the intracorporeal component covered by the at least one thermoplastic element to form an assembly; and
e. heating the assembly to fuse the thermoplastic material and secure the ePTFE sheet to the intracorporeal component.
51. The method of claim 50 wherein the ePTFE sheet is applied to an upper surface of the intracorporeal component.
52. The method of claim 50 wherein the ePTFE sheet is applied to a lower surface of the intracorporeal component.
53. The method of claim 51 wherein a second ePTFE sheet is applied to the lower surface of the intrecorporeal component.
54. The method of claim 50 wherein pressure is applied to the assembly at elevated temperature to fuse the thermoplastic polymeric material and secure the ePTFE sheet to the intracorporeal component.
US10/913,608 2004-08-05 2004-08-05 Ventricular partitioning device Abandoned US20060030881A1 (en)

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US10/913,608 US20060030881A1 (en) 2004-08-05 2004-08-05 Ventricular partitioning device
EP20050779614 EP1781186B1 (en) 2004-08-05 2005-08-04 Ventricular partitioning device
AU2005271261A AU2005271261B2 (en) 2004-08-05 2005-08-04 Ventricular partitioning device
PCT/US2005/028065 WO2006017809A2 (en) 2004-08-05 2005-08-04 Ventricular partitioning device
CA 2575509 CA2575509A1 (en) 2004-08-05 2005-08-04 Ventricular partitioning device
ES05779614T ES2410795T3 (en) 2004-08-05 2005-08-04 VAD partition
JP2007525062A JP4929172B2 (en) 2004-08-05 2005-08-04 Ventricular dividing apparatus
US11/860,438 US7897086B2 (en) 2004-08-05 2007-09-24 Method of making a laminar ventricular partitioning device
US12/893,832 US9078660B2 (en) 2000-08-09 2010-09-29 Devices and methods for delivering an endocardial device
JP2011103163A JP2011189140A (en) 2004-08-05 2011-05-02 Ventricular partitioning device
US13/827,927 US9332992B2 (en) 2004-08-05 2013-03-14 Method for making a laminar ventricular partitioning device
US13/828,184 US9332993B2 (en) 2004-08-05 2013-03-14 Devices and methods for delivering an endocardial device
JP2013162564A JP6047461B2 (en) 2004-08-05 2013-08-05 Ventricular dividing apparatus
US14/731,161 US20150265405A1 (en) 2000-08-09 2015-06-04 Devices and methods for delivering an endocardial device
US15/133,080 US10064696B2 (en) 2000-08-09 2016-04-19 Devices and methods for delivering an endocardial device

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US20080071298A1 (en) 2008-03-20
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US7897086B2 (en) 2011-03-01
EP1781186B1 (en) 2013-03-13
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EP1781186A2 (en) 2007-05-09
JP4929172B2 (en) 2012-05-09
JP2008508955A (en) 2008-03-27
JP2011189140A (en) 2011-09-29
WO2006017809A3 (en) 2006-04-27
WO2006017809A2 (en) 2006-02-16
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JP2013233448A (en) 2013-11-21
AU2005271261B2 (en) 2012-03-01

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