US20060030618A1 - Vanilloid receptor ligands and their use in treatments - Google Patents

Vanilloid receptor ligands and their use in treatments Download PDF

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Publication number
US20060030618A1
US20060030618A1 US11/100,272 US10027205A US2006030618A1 US 20060030618 A1 US20060030618 A1 US 20060030618A1 US 10027205 A US10027205 A US 10027205A US 2006030618 A1 US2006030618 A1 US 2006030618A1
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alkylnr
alkylor
haloalkyl
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US11/100,272
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Yunxin Bo
Partha Chakrabarti
Ning Chen
Elizabeth Doherty
Christopher Fotsch
Nianhe Han
Michael Kelly
Qingyian Liu
Mark Norman
Vassil Ognyanov
Xianghong Wang
Jiawang Zhu
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Amgen Inc
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Amgen Inc
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Priority to US11/100,272 priority Critical patent/US20060030618A1/en
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Definitions

  • VR1 vanilloid receptor 1
  • the vanilloid receptor 1 is the molecular target of capsaicin, the active ingredient in hot peppers. Julius et al. reported the molecular cloning of VR1 (Caterina et al., 1997).
  • VR1 is a non-selective cation channel which is activated or sensitized by a series of different stimuli including capsaicin and resiniferatoxin (exogenous activators), heat & acid stimulation and products of lipid bilayer metabolism, anandamide (Premkumar et al., 2000, Szabo et al., 2000, Gauldie et al., 2001, Olah et al., 2001) and lipoxygenase metabolites (Hwang et al., 2000).
  • VR1 is highly expressed in primary sensory neurons (Caterina et al., 1997) in rats, mice and humans (Onozawa et al., 2000, Mezey et al., 2000, Helliwell et al., 1998, Cortright et al., 2001). These sensory neurons innervate many visceral organs including the dermis, bones, bladder, gastrointestinal tract and lungs; VR1 is also expressed in other neuronal and non-neuronal tissues including but not limited to, CNS nuclei, kidney, stomach and T-Cells (Nozawa et al., 2001, Yiangou et al., 2001, Birder et al., 2001). Presumably expression in these various cells and organs may contribute to their basic properties such as cellular signaling and cell division.
  • capsaicin Prior to the molecular cloning of VR1, experimentation with capsaicin indicated the presence of a capsaicin sensitive receptor, which could increase the activity of sensory neurons in humans, rats and mice (Holzer, 1991; Dray, 1992, Szallasi and Blumberg 1996, 1999). The results of acute activation by capsaicin in humans was pain at injection site and in other species increased behavioral sensitivity to sensory stimuli (Szallasi and Blumberg, 1999). Capsaicin application to the skin in humans causes a painful reaction characterized not only by the perception of heat and pain at the site of administration but also by a wider area of hyperalgesia and allodynia, two characteristic symptoms of the human condition of neuropathic pain (Holzer, 1991).
  • VR1 gene knockout mice have been shown to have reduced sensory sensitivity to thermal and acid stimuli (Caterina et al., 2000)). This supports the concept that VR1 contributes not only to generation of pain responses (i.e. via thermal, acid or capsaicin stimuli) but also to the maintenance of basal activity of sensory nerves. This evidence agrees with studies demonstrating capsaicin sensitive nerve involvement in disease. Primary sensory nerves in humans and other species can be made inactive by continued capsaicin stimulation. This paradigm causes receptor activation induced desensitization of the primary sensory nerve—such reduction in sensory nerve activity in vivo makes subjects less sensitive to subsequent painful stimuli.
  • capsaicin and resinferatoxin exogenous activators of VR1
  • capsaicin and resinferatoxin produce desensitization and they have been used for many proof of concept studies in in vivo models of disease (Holzer, 1991, Dray 1992, Szallasi and Blumberg 1999).
  • VR1 agonists or antagonists have use as analgesics for the treatment of pain of various genesis or aetiology, for example acute, inflammatory and neuropathic pain, dental pain and headache, particularly vascular headache such as migraine, cluster headache and mixed vascular syndromes as well as non-vascular, tension headache. They are also useful as anti-inflammatory agents for the treatment of inflammatory diseases or conditions, for example the treatment of arthritis and rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders (e.g. uvetis), inflammatory or unstable bladder disorders (e.g. cystitis and urinary incontinence), psoriasis and skin complaints with inflammatory components, as well as other chronic inflammatory conditions.
  • inflammatory diseases or conditions for example the treatment of arthritis and rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders (e.g. uvetis), inflammatory or unstable bladder disorders (e.g. cystitis and urinary incontinence), psoria
  • neuropathic pain and associated hyperalgesia and allodynia e.g. trigeminal or herpetic neuralgia, diabetic neuropathy pain, causalgia, sympathetically maintained pain and deafferentation syndromes such as brachial plexus avulsion.
  • neuropathic pain and associated hyperalgesia and allodynia e.g. trigeminal or herpetic neuralgia, diabetic neuropathy pain, causalgia, sympathetically maintained pain and deafferentation syndromes such as brachial plexus avulsion.
  • prophylactic or curative treatment of asthma of epithelial tissue damage or dysfunction, e.g. spontaneous lesions, of herpes simplex, and in the control of disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular e.g.
  • gastrointestinal disorders such as gastric ulceration, duodenal ulcers, inflammatory bowel disease and diarrhea, gastric lesions induced by necrotising agents, for example ethanol or chemotherapeutic agents, hair growth, for the treatment of vasomotor or allergic rhinitis and for the treatment of bronchial disorders or bladder disorders, such as bladder hyper-reflexia.
  • the present invention comprises a new class of compounds useful in the treatment of diseases, such as vanilloid-receptor-mediated diseases and other maladies, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis.
  • diseases such as vanilloid-receptor-mediated diseases and other maladies, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis.
  • the compounds of the invention are useful for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrot
  • the invention also comprises pharmaceutical compositions comprising the compounds, methods for the treatment of vanilloid-receptor-mediated diseases, such as inflammatory or neuropathic pain, asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis diseases, using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of the compounds of the invention.
  • vanilloid-receptor-mediated diseases such as inflammatory or neuropathic pain, asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis diseases.
  • the compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, wherein A, R 1 , R 2 , R 3 , R 4 , X and Y are defined below.
  • One aspect of the current invention relates to compounds having the general structure: wherein:
  • R 1 is or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ;
  • R 2 is H, hydroxy, halo, C 1-6 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ; or R 1 and R 2 together are
  • R 3 is H or C 1-4 alkyl; or R 1 and R 3 together are
  • R 4 is R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR
  • R 5 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a or —NR a C 1-6 alkylOR a ; or R 5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S;
  • R 6 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a or —NR a C 1-6 alkylOR a ; or R 5 and R 6 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-6 alkyl,
  • R 7 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a or —NR a —C 1-6 alkylOR a ;
  • R 8 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a or —NR a C 1-6 alkylOR a ; or R 7 and R 8 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-6 alkyl,
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, 'OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a or —NR a —C 1-6 alkylOR a ;
  • R 10 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C( ⁇ O
  • R 11 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylR c , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC
  • R 12 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C( ⁇ O
  • R 11 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylR c , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl
  • R 13 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 14 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C( ⁇ O
  • R a is independently, at each instance, H, phenyl, benzyl or C 1-6 alkyl
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl-O—R a ;
  • R c is phenyl substituted by 0, 1 or 2 groups selected from halo, C 1-3 haloalkyl, —OR a and —NR a R a ; or R c is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-3 haloalkyl, —OR a and —NR a R a ;
  • L 1 is a bond, —CH 2 CH 2 — or —CH ⁇ CH—;
  • L 2 is NR a , O, S( ⁇ O) n , —N ⁇ CH—, —CH 2 NR a —, —CH ⁇ N— or —NR a CH 2 —;
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C( ⁇ O
  • L 4 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein at least one of the carbon atoms in the bridge is substituted by ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OC 1-6 alkyl, —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a C 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C
  • X is O, S or NR a ; or X and R 2 together are ⁇ N—CH ⁇ CH—, ⁇ C—O—, ⁇ C—S—, or ⁇ C—NR a —;
  • Y is NH or O
  • n is independently, at each instance, 0, 1 or 2; with the proviso that when R 1 is 4-chlorophenyl, then R 4 is not 3-methoxyphenyl.
  • R 1 is or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ;
  • R 2 is H, hydroxy, halo, C 1-6 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ; and
  • R 3 is H or C 1-4 alkyl.
  • R 1 is
  • R 7 is independently, at each instance, C 2-9 alkyl or C 1-4 haloalkyl.
  • R 1 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 2 is or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 2 is
  • R 2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • X and R together are ⁇ N—CH ⁇ CH—, ⁇ C—O—, ⁇ C—S—, or ⁇ C—NR a —.
  • R 4 is
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl-O—R a ;
  • Y 2 is —NR a — or —O—.
  • R 4 is
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C( ⁇ O
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl-O—R a ;
  • Y 2 is —NR b — or —O—.
  • R 4 is
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C( ⁇ O
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl-O—R a ;
  • Y 2 is —NR b — or —O—.
  • R 4 is
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C( ⁇ O
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl-O—R a ;
  • Y 2 is —NR b — or —O—.
  • R 4 is
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 —O—R a ;
  • Y 2 is —NR a — or —O—.
  • R 4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, OR a , NR a R a , C 1-6 alkyl and C 1-3 haloalkyl; and saturated carbon atoms may be additionally substituted by ⁇ O.
  • R 4 is
  • R 10 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 11 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylR c , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC
  • R 12 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C( ⁇
  • R 13 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C( ⁇ O)
  • R 14 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 haloalkyl, —OR a and —NR a R a .
  • Another aspect of the invention relates to a compound having the structure: or any pharmaceutically-acceptable salt thereof, wherein:
  • n is independently, at each instance, 0, 1 or 2.
  • R 1 is or R 1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R 5 ; or R 1 is R e substituted by 1, 2 or 3 substituents independently selected from R 5 ;
  • R 15 is, independently, in each instance, R 10 , C 1-8 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , —(CH 2 ) n phenyl substituted by 0, 1, 2 or 3 substituents independently selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 10 ;
  • R 16 is, independently, in each instance, H, halo, —NH 2 , —NHC 1-3 alkyl, —N(C 1-3 alkyl)C 1-3 alkyl or C 1-3 alkyl;
  • R 4 is R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, oxo, —OR d , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —OC 1-6 alkylC( ⁇ O)OR d , —NR d R
  • R 5 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d , —NR d C 2-6 alkylOR d , naphthyl, —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR d R d , —NR d C( ⁇ O)R d , —NR d C( ⁇ O)NR d R d , —NR d CO 2 (C 1-6 alkyl), —C 1-8 alkylOR
  • R 6 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d or NR d C 2-6 alkylOR d , —C 1-8 alkylOR d , —C 1-6 alkylNR d R d , —S(C 1-6 alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R 10 ; or R 6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently
  • R 7 is independently, at each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d , —NR d C 2-6 alkylOR d , —C 1-8 alkylOR d , —C 1-6 alkylNR d R d or —S(C 1-6 alkyl); or R 7 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C 1-2 haloalkyl and C 1-3 alkyl;
  • R 8 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d or —NR d C 2-6 alkylOR d , —C 1-8 alkylOR d , —C 1-6 alkylNR d R d , —S(C 1-6 alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R 10 , or R 8 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents
  • R 9 is independently, at each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d or —NR d C 2-6 alkylOR d , —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR d R d , —NR d C( ⁇ O)(C 1-6 alkyl), —NR d C( ⁇ O)NR d R d , —NR d CO 2 (C 1-6 alkyl), —C
  • R 10 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR d R d ,
  • R 11 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR d R d ,
  • R 12 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR d R d ,
  • R 13 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR d R d ,
  • R 14 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR d R d , —
  • R d is independently, at each instance, H, phenyl, benzyl or C 1-6 alkyl
  • R e is a heterocycle selected from the group of thiophene, pyrrole, 1,3-oxazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, 1H-1,2,3-triazole, isothiazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole, 1,2,3,4-oxatriazole, 1,2,3,4-thiatriazole, 1H-1,2,3,4-tetraazole, 1,2,3,5-oxatriazole, 1,2,3,5-thiatriazole, furan, imidazol-1-yl, imidazol-4-yl, 1,2,4-triazol-4-yl, 1,2,4-triazol-5-yl, isoxazol-3-yl, isoxazol-5-yl, pyrazol-3-yl, pyrazol-5-y
  • R f is phenyl substituted by 0, 1 or 2 groups selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OR d and —NR d R d ; or R f is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OR d and —NR d R d ; and
  • R g is hydrogen or —CH 3 .
  • R 16 is halo, —NH 2 , —NHC 1-3 alkyl, —N(C 1-3 alkyl)C 1-3 alkyl or C 1-3 alkyl.
  • R 10 is independently, at each instance, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇
  • R 1 is
  • R 7 is C 1-5 alkyl, halo or C 1-4 haloalkyl.
  • R 1 is naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R 5 .
  • R 1 is R e substituted by 0, 1, 2 or 3 substituents independently selected from R 5 .
  • R 1 is R e substituted by 1, 2 or 3 substituents independently selected from R 5 .
  • R 4 is
  • R 10 and R 11 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 al
  • R 11 and R 12 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, oxo, —OR d , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —OC 1-6 alkylC( ⁇ O
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, oxo, —OR d , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —OC 1-6 alkylC( ⁇ O)
  • R 4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, OR d , NR d R d , C 1-6 alkyl and C 1-3 haloalkyl; and saturated carbon atoms may be additionally substituted by ⁇ O.
  • R 4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, OR d , NR d R d , C 1-6 alkyl and C 1-3 haloalkyl; and saturated carbon atoms may be additionally substituted by ⁇ O.
  • Another aspect of the invention relates to a compound having the structure: or any pharmaceutically-acceptable salt thereof, wherein:
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Y is NH, O or S
  • R 1 is or R 1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R 5 ; or R 1 is R e substituted by 1, 2 or 3 substituents independently selected from R 5 ;
  • R 15 is, independently, in each instance, R 10 , C 1-8 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , —(CH 2 ) n phenyl substituted by 0, 1, 2 or 3 substituents independently selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 10 ;
  • R 16 is, independently, in each instance, H, halo, —NH 2 , —NHC 1-3 alkyl, —N(C 1-3 alkyl)C 1-3 alkyl or C 1-3 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 5 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d , —NR d C 2-6 alkylOR d , naphthyl, —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR d R d , —NR d C( ⁇ O)R d , —NR d C( ⁇ O)NR d R d , —NR d CO 2 (C 1-6 alkyl), —C 1-8 alkylOR
  • R 6 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d or —NR d C 2-6 alkylOR d , —C 1-8 alkylOR d , —C 1-6 alkylNR d R d , —S(C 1-6 alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R 10 ; or R 6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents
  • R 7 is independently, at each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d , —NR d C 2-6 alkylOR d , —C 1-8 alkylOR d , —C 1-6 alkylNR d R d or —S(C 1-6 alkyl); or R 7 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C 1-2 haloalkyl and C 1-3 alkyl;
  • R 8 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d , —NR d C 2-6 alkylOR d , —C 1-8 alkylOR d , —C 1-6 alkylNR d R d , —S(C 1-6 alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R 10 , or R 6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituent
  • R 9 is independently, at each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d or —NR d C 2-6 alkylOR d , —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR d R d , —NR d C( ⁇ O)(C 1-6 alkyl), —NR d C( ⁇ O)NR d R d , —NR d CO 2 (C 1-6 alkyl), —C 1-8 alkylOR d ,
  • R 10 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR d R d ,
  • R d is independently, at each instance, H, phenyl, benzyl or C 1-6 alkyl
  • R e is a heterocycle selected from the group of thiophene, pyrrole, 1,3-oxazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, 1H-1,2,3-triazole, isothiazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole, 1,2,3,4-oxatriazole, 1,2,3,4-thiatriazole, 1H-1,2,3,4-tetraazole, 1,2,3,5-oxatriazole, 1,2,3,5-thiatriazole, furan, imidazol-1-yl, imidazol-4-yl, 1,2,4-triazol-4-yl, 1,2,4-triazol-5-yl, isoxazol-3-yl, isoxazol-5-yl, pyrazol-3-yl, pyrazol-5-y
  • R f is phenyl substituted by 0, 1 or 2 groups selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OR d and —NR d R d ; or R f is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OR d and —NR d R d ;
  • R g is hydrogen or —CH 3 ;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q .
  • Y is NH
  • Y is O.
  • Y is S.
  • R 1 is
  • R 7 is C 1-5 alkyl, halo or C 1-4 haloalkyl.
  • R 1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R 5 .
  • R 1 is R e substituted by 1, 2 or 3 substituents independently selected from R 5 ;
  • R 15 is —(CH 2 ) n phenyl substituted by 0, 1, 2 or 3 substituents independently selected from R 10 .
  • R 15 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 10 .
  • R 15 is C 1-8 alkyl substituted by 0, 1 or 2 substituents selected from R 10 .
  • R 15 is selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR d R d , —C( ⁇ NR d )NR d R d , —OR d , —OC( 50 O)(C 1-8 alkyl), —OC( ⁇ O)NR d R d , —OC( ⁇ O)N(R d )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —SR d , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR
  • R 16 is, independently, in each instance, halo, —NH 2 , —NHC 1-3 alkyl, —N(C 1-3 alkyl)C 1-3 alkyl or C 1-3 alkyl.
  • R 4 is an unsaturated 6-membered ring containing 0 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)NR m R m , —OC
  • R 4 is a saturated or unsaturated 6-membered ring containing 0 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m ,
  • R 9 is H.
  • R 9 is independently, at each instance, C 1-8 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR d R d , —OC 2-6 alkylOR d , —NR d R d , —NR d C 1-4 haloalkyl, —NR d C 2-6 alkylNR d R d or —NR d C 2-6 alkylOR d , —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR d R d , —NR d C( ⁇ O)(C 1-6 alkyl), —NR d C( ⁇ O)NR d R d , —NR d CO 2 (C 1-6 alkyl),
  • R 9 is a —(CR q R q ) o phenyl wherein the phenyl is substituted with 0, 1, 2, or 3 substituents independently selected from R 10 .
  • R 9 is —(CR q R q ) o Het wherein Het is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R 10 ; or R 9 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C 1-2 haloalkyl and C 1-3 alkyl.
  • Another aspect of the invention relates to a compound having the structure: or any pharmaceutically-acceptable salt thereof, wherein:
  • Y is O or S
  • n is independently, at each instance, 0, 1 or 2.
  • R 1 is or R 1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R 5 ; or R 1 is R i substituted by 1, 2 or 3 substituents independently selected from R 5 ;
  • R 15 is, independently, in each instance, R 10 , C 1-8 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , —(CH 2 ) n phenyl substituted by 0, 1, 2 or 3 substituents independently selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, the heterocycle and bridge being substituted by 0, 1, 2 or 3 substituents independently selected from R 10 ;
  • R 16 is, independently, in each instance, H, halo, —NH 2 , —NHC 1-3 alkyl, —N(C 1-3 alkyl)C 1-3 alkyl, —OC 1-3 alkyl, —C 1-2 haloalkyl, —OC 1-2 haloalkyl or C 1-3 alkyl;
  • R 4 is wherein when R 1 is bromophenyl, methylphenyl or trifluoromethylphenyl, R 4 is not trifluoromethylphenyl or trifluoromethylhalophenyl; or R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, wherein each of the carbon atoms of the heterocycle is substituted by H, C 1-9 alkyl, C 1-4 haloalkyl, halo, cyano, oxo, —OR h , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —OC 1-6 alkylC( ⁇ O)OR h , —NR h R h , —NR
  • R 5 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, nitro, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylOR h , naphthyl, —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR h R h , —NR h C( ⁇ O)R h , —NR h C( ⁇ O)NR h R h , —NR h CO 2 (C 1-6 alkyl), —C 1-8 alkylOR h ,
  • R 6 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h or —NR h C 2-6 alkylOR h , —C 1-8 alkylOR h , —C 1-6 alkylNR h R h , —S(C 1-6 alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R 10 ; or R 6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents
  • R 7 is independently, at each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, bromo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylOR h , —C 1-8 alkylOR h , —C 1-6 alkylNR h R h or —S(C 1-6 alkyl); or R 7 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C 1-2 haloalkyl and C 1-3 alkyl;
  • R 8 is independently, at each instance, H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylOR h , —C 1-8 alkylOR h , —C 1-6 alkylNR h R h , —S(C 1-6 alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R 10 , or R 8 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituent
  • R 9 is independently, at each instance, H, C 1-8 alkyl, C 1-4 haloalkyl, halo, nitro, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h R h or —NR h C 2-6 alkylOR h , —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR h R h , —NR h C( ⁇ O)(C 1-6 alkyl), —NR h C( ⁇ O)NR h R h , —NR h CO 2 (C 1-6 alkyl), —C 1-8 alkylOR h , —C 1-6 alkylNR h R
  • R 10 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR h R h ,
  • R 11 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR h R h ,
  • R 12 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR h R h , —S( ⁇ O) 2 N(R h )
  • R 13 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR h R h ,
  • R 14 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR h R h ,
  • R h is independently, at each instance, H, phenyl, benzyl or C 1-6 alkyl, the phenyl, benzyl and C 1-6 alkyl being substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OC 1-4 alkyl, —NH 2 , —NHC 1-4 alkyl, —N(C 1-4 alkyl)C 1-4 alkyl;
  • R i is a heterocycle selected from the group of thiophene, pyrrole, 1,3-oxazole, 1,3-thiazol-5-yl, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, 1H-1,2,3-triazole, isothiazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole 1,2,3,4-oxatriazole, 1,2,3,4-thiatriazole, 1H-1,2,3,4-tetraazole, 1,2,3,5-oxatriazole, 1,2,3,5-thiatriazole, furan, imidazol-1-yl, imidazol-3-yl, imidazol-4-yl, 1,2,4-triazole, 1,2,4-triazole, isoxazole, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl
  • R j is phenyl substituted by 0, 1 or 2 groups selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OR h and —NR h R h ; or R j is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 alkyl, C 1-3 haloalkyl, —OR h and —NR h R h ; and
  • R k is hydrogen or —CH 3 .
  • R 1 is
  • R 7 is C 2-6 alkyl or C 1-4 haloalkyl.
  • R 1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R 5 .
  • R 1 is R i substituted by 1, 2 or 3 substituents independently selected from R 5 .
  • R i is substituted by one substituent selected from halo, C 1-4 haloalkyl and C 1-5 alkyl, and additionally by 0, 1 or 2 substituents independently selected from R 5 .
  • R 15 is H.
  • R 15 is R 10 , C 1-8 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, the heterocycle and bridge being substituted by 0, 1, 2 or 3 substituents independently selected from R 10 ; or R 15 is —(CH 2 ) n phenyl substituted by 0, 1, 2 or 3 substituents independently selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(
  • R 16 is H
  • R 16 is halo, —NHC 1-3 alkyl, —N(C 1-3 alkyl)C 1-3 alkyl, —OC 1-3 alkyl, —C 1-2 haloalkyl, —OC 1-2 haloalkyl or C 1-3 alkyl.
  • R 4 is wherein at least one of R 10 , R 11 , R 12 , R 13 and R 14 is other than C 1-4 haloalkyl or halo.
  • At least one of R 10 , R 11 , R 12 , R 13 and R 14 is —OR h or —NR h R h .
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, wherein each of the carbon atoms of the heterocycle is substituted by H, C 1-9 alkyl, C 1-4 haloalkyl, halo, cyano, oxo, —OR h , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —OC 1-6 alkylC( ⁇ O)OR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —N h C 2-6 alkyl
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1 or 2 atoms selected from O, N and S, wherein each of the carbon atoms of the heterocycle is substituted by H, C 1-9 alkyl, C 1-4 haloalkyl, halo, cyano, oxo, —OR h , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —OC 1-6 alkylC( ⁇ O)OR h , NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylOR h , —C( ⁇ O)C 1-6 alkyl
  • R 4 is an 8-, 9-, 10- or 11-membered bicyclic ring, containing 1, 2, 3 or 4 N atoms and 0, 1 or 2 atoms selected from S and O with the remainder being carbon atoms, wherein each of the carbon atoms of the ring is substituted by H, C 1-9 alkyl, C 1-4 haloalkyl, halo, cyano, oxo, —OR h , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —OC 1-6 alkylC( ⁇ O)OR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylNR h R h , —NR
  • R 4 is an 8-, 9-, 10- or 11-membered bicyclic ring, containing 0, 1, 2, 3 or 4 N atoms and 0, 1 or 2 atoms selected from S and O with the remainder being carbon atoms, wherein at least one of the carbon atoms of the ring is substituted by C 1-9 alkyl, C 1-4 haloalkyl, halo, cyano, oxo, —OR h , —S( ⁇ O) n C 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —OC 1-6 alkylC( ⁇ O)OR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2 h C 2 h C 2 h , —NR
  • R 5 and R 9 are each independently selected from H, C 1-4 haloalkyl, halo, nitro, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylOR h , —CO 2 (C 1-6 alkyl), —C( ⁇ O)(C 1-6 alkyl), —C( ⁇ O)NR h R h , —NR h C( ⁇ O)R h , —NR h C( ⁇ O)NR h R h , —NR h CO 2 (C 1-6 alkyl), —C 1-8 alkylOR
  • R 6 and R 8 are each independently selected from H, C 1-5 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, C 2-6 alkylNR h R h or —NR h C 2-6 alkylOR h , —C 1-8 alkylOR h , —C 1-6 alkylNR h R h and —S(C 1-6 alkyl).
  • R 7 is independently, at each instance, C 1-8 alkyl, C 1-4 haloalkyl, —OC 1-4 haloalkyl, —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —NR h R h , —NR h C 1-4 haloalkyl, —NR h C 2-6 alkylNR h R h , —NR h C 2-6 alkylOR h , —C 1-8 alkylOR h , —C 1-6 alkylNR h R h or —S(C 1-6 alkyl).
  • R 10 and R 14 are each independently selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —
  • R 11 and R 13 are independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)(C 1-8 alkyl), —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alky
  • R 12 is independently, at each instance, selected from H, C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)O(C 1-8 alkyl), —C( ⁇ O)NR h R h , —C( ⁇ NR h )NR h R h , —OR h , —OC( ⁇ O)(C 1-8 alkyl), —OC( ⁇ O)NR h R h , —OC( ⁇ O)N(R h )S( ⁇ O) 2 (C 1-8 alkyl), —OC 2-6 alkylNR h R h , —OC 2-6 alkylOR h , —SR h , —S( ⁇ O)(C 1-8 alkyl), —S( ⁇ O) 2 (C 1-8 alkyl), —S( ⁇ O) 2 NR h R h , —SR h , —S( ⁇ O)(
  • Y is O.
  • Y is S.
  • Another aspect of the invention relates to a compound having the structure: wherein:
  • X is O, S or NR m ;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q ;
  • R 3 is H or C 1-4 alkyl
  • R 5 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c
  • R 6 is, independently at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R 8 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; and (A) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)R n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH; or (B) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ ) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n ,
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c ;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (D) R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S(
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (E) R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH.
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms elected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ ,)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m R m
  • R 4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —NR m R m or —NR m —C 1-4 haloalkyl.
  • R 7 is C 1-5 alkyl, C 1-4 haloalkyl, I, Br or Cl.
  • R 7 is tert-butyl or trifluoromethyl.
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • R o is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • Y is O.
  • Y is NH
  • R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ ,)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; [C 1-8 alkyl, C 1-5 haloalkyl, I, Br or Cl]
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 1 1-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH.
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m ,
  • R 4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ ,)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —NR m R m or —NR m —C 1-4 haloalkyl.
  • R 7 is C 1-5 alkyl, C 1-4 haloalkyl, I, Br or Cl.
  • R 7 is tert-butyl or trifluoromethyl.
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • R o is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • Y is O.
  • Y is NH
  • R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br;
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 4 is a heterocycle selected from indole, 3H-indole, benzo[b]furan, benzothiophene, 1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 1,2,3,4-tetrahydroquinoline, isoquinoline, cinnoline, phthalazine, quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m
  • R 4 is a heterocycle selected from 6-indole, 7-indole, 6-3H-indole, 7-3H-indole, 6-benzo[b]furan, 7-benzo[b]furan, 6-benzothiophene, 7-benzothiophene, 6-1H-indazole, 7-1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 7-1,2,3,4-tetrahydroquinoline, 8-1,2,3,4-tetrahydroquinoline, isoquinolin-7-yl, isoquinolin-8-yl, 7-cinnoline, 8-cinnoline, phthalazine, 7-quinazoline, 8-quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1
  • R 9 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m .
  • R 9 is H.
  • Z is CR 8 .
  • Z is N.
  • R 7 is tert-butyl or trifluoromethyl.
  • R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O
  • R 2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 NR m R m ,
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S(S(S(S(S(S(S( ⁇ O)
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)
  • R 4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n
  • R 7 is tert-butyl or trifluoromethyl.
  • R 9 is H.
  • Z is CR 8.
  • Z is N.
  • R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 2-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —SR m , —S( ⁇ O)R n
  • Z is CR 8 .
  • Z is N.
  • Another aspect of the invention relates to a compound having the structure: wherein:
  • X is O, S or NR m ;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q ;
  • R 3 is H or C 1-4 alkyl
  • R 5 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c
  • R 6 is, independently at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R 8 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; and (A) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH; or (B) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 1 1-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 al
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c ;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (D) R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S(
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (E) R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n ,—OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m ,
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ ,)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH.
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m ,
  • R 4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —NR m R m or —NR m —C 1-4 haloalkyl.
  • R 7 is C 1-5 alkyl, C 1-4 haloalkyl, I, Br or Cl.
  • R 7 is tert-butyl or trifluoromethyl.
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • R o is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • Y is O.
  • Y is NH
  • R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , ‘C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; [C 1-8 alkyl, C 1-5 haloalkyl, I, Br or Cl]
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH.
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m ,
  • R 4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —NR m R m or —NR m —C 1-4 haloalkyl.
  • R 7 is C 1-5 alkyl, C 1-4 haloalkyl, I, Br or Cl.
  • R 7 is tert-butyl or trifluoromethyl.
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • R o is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p .
  • Y is O.
  • Y is NH
  • R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 al
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br;
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH; and Z is CR 8 or N.
  • R 4 is a heterocycle selected from indole, 3H-indole, benzo[b]furan, benzothiophene, 1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 1,2,3,4-tetrahydroquinoline, isoquinoline, cinnoline, phthalazine, quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m
  • R 4 is a heterocycle selected from 6-indole, 7-indole, 6-3H-indole, 7-3H-indole, 6-benzo[b]furan, 7-benzo[b]furan, 6-benzothiophene, 7-benzothiophene, 6-1H-indazole, 7-1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 7-1,2,3,4-tetrahydroquinoline, 8-1,2,3,4-tetrahydroquinoline, isoquinolin-7-yl, isoquinolin-8-yl, 7-cinnoline, 8-cinnoline, phthalazine, 7-quinazoline, 8-quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1
  • R 9 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m .
  • R 9 is H.
  • Z is CR 8 .
  • Z is N.
  • R 7 is tert-butyl or trifluoromethyl.
  • R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇
  • R 2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O'C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 NR m R m ,
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)
  • R 4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n
  • R 7 is tert-butyl or trifluoromethyl.
  • R 9 is H.
  • Z is CR 8 .
  • Z is N.
  • R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 2, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m ,
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 R n , —S( ⁇
  • Z is CR 8 .
  • Z is N.
  • Another aspect of the invention relates to a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrot
  • R 1 is or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5, R 6 and R 7 ;
  • R 2 is H, hydroxy, halo, C 1-6 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ; or R 1 and R 2 together are
  • R 3 is H or C 1-4 alkyl; or R 1 and R 3 together are
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R
  • R 5 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a—C 1-6 alkylNR a R a or —NR a C 1-6 alkylOR a ; or R 5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S;
  • R 6 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a or —NR a —C 1-6 alkylOR a ; or R 5 and R 6 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-6 al
  • R 7 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a or —NR a —C 1-6 alkylOR a ;
  • R 8 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a C 1-6 alkylNR a R a or —NR a —C 1-6 alkylOR a ; or R 7 and R 8 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-6 alkyl
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a or —NR a —C 1-6 alkylOR a ;
  • R 10 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 11 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylR c , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC
  • R 12 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 13 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 14 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R a is independently, at each instance, H, phenyl, benzyl or C 1-6 alkyl
  • R c is phenyl substituted by 0, 1 or 2 groups selected from halo, C 1-3 haloalkyl, —OR a and —NR a R a ; or R c is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-3 haloalkyl, —OR a and —NR a R a ;
  • L 1 is a bond, —CH 2 CH 2 — or —CH ⁇ CH—;
  • L 2 is NR a , O, S( ⁇ O) n , —N ⁇ CH—, —CH 2 NR a —, —CH ⁇ N— or —NR a CH 2 —;
  • X is O, S or NR a ; or X and R 2 together are ⁇ N—CH ⁇ CH—, ⁇ C—O—, ⁇ C—S—, or ⁇ C—NR a —;
  • Y is NH or O
  • n is independently, at each instance, 0, 1 or 2; with the proviso that when R 1 is 4-chlorophenyl, then R 4 is not 3-methoxyphenyl.
  • R 1 is or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ;
  • R 2 is H, hydroxy, halo, C 1-6 alkyl substituted by 0, 1 or 2 substituents selected from R 10 , or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 ; and
  • R 3 is H or C 1-4 alkyl.
  • R 1 is
  • R 7 is independently, at each instance, C 2-9 alkyl or C 1-4 haloalkyl.
  • R 1 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 2 is or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 2 is
  • R 2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R 5 , R 6 and R 7 .
  • R 1 and R 2 together are
  • R 1 and R 3 together are
  • X and R 2 together are ⁇ N—CH ⁇ CH—, ⁇ C—O—, ⁇ C—S—, or ⁇ C—NR a —.
  • R 4 is
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl—O—R a ;
  • Y 2 is —NR a — or —O—.
  • R 4 is
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C( ⁇ O
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl—O—R a ;
  • Y 2 is —NR b — or —O—.
  • R 4 is
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ O)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 alkylNR a C( ⁇ O
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl—O—R a ;
  • Y 2 is —NR b — or —O—.
  • R 4 is
  • L 3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ⁇ O, —OR a , —C 1-6 alkylOR a , —C 1-6 alkyl, —NR a R a , —C 1-6 alkylNR a R a , —C( ⁇ O)OR a , —C( ⁇ O)NR a R a , —C 1-3 alkylC( ⁇ O)OR a , —C 1-3 alkylC( ⁇ O)NR a R a , —OC( ⁇ N)C 1-6 alkyl, —NR a C( ⁇ O)C 1-6 alkyl, —C 1-3 alkylOC( ⁇ O)C 1-6 alkyl or —C 1-3 akylNR a C( ⁇
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl—O—R a ;
  • Y 2 is —NR b — or —O—.
  • R 4 is
  • R b is H, C 1-6 alkyl, —C( ⁇ O)C 1-6 alkyl, C 1-6 alkyl—O—R a ;
  • Y 2 is —NR a — or —O—.
  • R 4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, OR a , NR a R a , C 1-6 alkyl and C 1-3 haloalkyl; and saturated carbon atoms may be additionally substituted by ⁇ O.
  • R 4 is
  • R 10 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a , —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —
  • R 11 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylR c , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC
  • R 12 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 akylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C
  • R 13 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 14 is independently, at each instance, H, C 1-9 alkyl, —C 1-3 alkylOR a , C 1-4 haloalkyl, halo, nitro, cyano, —OR a , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR a R a , —O—C 1-6 alkylOR a , —O—C 1-6 alkylC( ⁇ O)OR a , —NR a R a , —NR a —C 1-4 haloalkyl, —NR a —C 1-6 alkylNR a R a , —NR a —C 1-6 alkylOR a , —C( ⁇ O)C 1-6 alkyl, —C( ⁇ O)OC 1-6 alkyl, —OC( ⁇ O)C 1-6 alkyl, —C(
  • R 4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C 1-4 haloalkyl, —OR a and —NR a R a .
  • Another aspect of the invention relates to a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrot
  • Another aspect of the invention involves a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents
  • X is O, S or NR m ;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q ;
  • R 3 is H or C 1-4 alkyl
  • R 5 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c
  • R 6 is, independently at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R 8 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; and (A) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH; or (B) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c ;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (D) R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S(
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (E) R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m
  • R 7 is C 2-6 alkyl, C 1-5 haloalkyl, I or Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • Another aspect of the invention involves a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents
  • X is O, S or NR m ;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q ;
  • R 3 is H or C 1-4 alkyl
  • R 5 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c
  • R 6 is, independently at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R 8 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; and (A) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or -NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH; or (B) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c ;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (D) R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S(
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (E) R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m
  • R 7 is C 2-6 alkyl, C 1-5 haloalkyl, I or Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O-C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • Another aspect of the invention involves a pharmaceutical composition
  • a pharmaceutical composition comprising a compound according to any of the above embodiments and a pharmaceutically-acceptable diluent or carrier.
  • Another aspect of the invention involves the use of any of the above compound embodiments as a medicament.
  • Another aspect of the invention relates to the use of a compound according the any one of the above embodiments in the manufacture of a medicament for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric
  • Another aspect of the invention relates to the manufacture of a medicament for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions
  • X is O, S or NR m ;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q ;
  • R 3 is H or C 1-4 alkyl
  • R 5 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c
  • R 6 is, independently at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R 8 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; and (A) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH; or (B) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c ;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (D) R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2- 6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S(
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (E) R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m
  • R 7 is C 2-6 alkyl, C 1-5 haloalkyl, I or Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • Another aspect of the invention relates to the manufacture of a medicament for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions
  • X is O, S or NR m ;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • R m is independently at each instance H or R n ;
  • R n is independently at each instance C 1-8 alkyl, phenyl or benzyl;
  • R q is independently in each instance H, C 1-4 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R
  • R s is R n substituted by 0, 1, 2 or 3 substituents independently selected from R q ;
  • R 3 is H or C 1-4 alkyl
  • R 5 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c
  • R 6 is, independently at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R 8 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ; and (A) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • Y is O or NH; or (B) R 1 is
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • R o is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from R p ;
  • R p is independently at each instance C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇ O)R n
  • R 2 is H, —OR m , halo, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-9 alkyl, oxo, C 1-4 haloalkyl, halo, nitro, cyano, —OR m , —S( ⁇ O) n C 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6
  • R 7 is C 1-8 alkyl, C 1-5 haloalkyl, I or Br
  • R 9 is H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m , —NR m —C 1-6 alkylOR m , or —(CH 2 ) n R c ;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (D) R 1 is
  • R 2 is C 1-6 alkyl substituted by 1, 2 or 3 substituents selected from C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m , —S( ⁇ O) 2 N(R m )C( ⁇
  • R 2 is —(C(R q ) 2 ) o phenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylNR m R m , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S(
  • R 2 is —(C(R q ) 2 ) o R r , wherein R r is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)R n , —C( ⁇ O)OR n , —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR m , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m
  • R 7 is C 2-8 alkyl, C 1-5 haloalkyl, I, Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N; or (E) R 1 is
  • R 2 is H, —OR m , Cl, C 1-3 haloalkyl or C 1-6 alkyl;
  • R 4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C 1-8 alkyl, C 1-4 haloalkyl, halo, cyano, nitro, —C( ⁇ O)NR m R m , —C( ⁇ NR m )NR m R m , —OR n , —OC( ⁇ O)R n , —OC( ⁇ O)NR m R m , —OC( ⁇ O)N(R m )S( ⁇ O) 2 R n , —OC 2-6 alkylOR m , —SR m , —S( ⁇ O)R n , —S( ⁇ O) 2 R n , —S( ⁇ O) 2 NR m R m
  • R 7 is C 2-6 alkyl, C 1-5 haloalkyl, I or Br;
  • R 9 is independently, at each instance, H, C 1-9 alkyl, C 1-4 haloalkyl, halo, nitro, cyano, —OC 1-6 alkyl, —O—C 1-4 haloalkyl, —O—C 1-6 alkylNR m R m , —O—C 1-6 alkylOR m , —NR m R m , —NR m —C 1-4 haloalkyl, —NR m —C 1-6 alkylNR m R m or —NR m —C 1-6 alkylOR m ;
  • Y is NH
  • Z is CR 8 or N.
  • the compounds of this invention may have in general several asymmetric centers and are typically depicted in the form of racemic mixtures. This invention is intended to encompass racemic mixtures, partially racemic mixtures and separate enantiomers and diasteromers.
  • C ⁇ - ⁇ alkyl means an alkyl group comprising from ⁇ to ⁇ carbon atoms in a branched, cyclical or linear relationship or any combination of the three.
  • the alkyl groups described in this section may also contain a double or triple bond. Examples of C 1-6 alkyl include, but are not limited to the following:
  • Halo means a halogen atoms selected from F, Cl, Br and I.
  • C ⁇ - ⁇ haloalkyl means an alkyl group, as described above, wherein any number—at least one—of the hydrogen atoms attached to the alkyl chain are replaced by F, Cl, Br or I.
  • Heterocycle means a ring comprising at least one carbon atom and at least one other atom selected from N, O and S. Examples of heterocycles that may be found in the claims include, but are not limited to, the following:
  • “Pharmaceutically-acceptable salt” means a salt prepared by conventional means, and are well known by those skilled in the art.
  • the “pharmacologically acceptable salts” include basic salts of inorganic and organic acids, including but not limited to hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulphonic acid, ethanesulfonic acid, malic acid, acetic acid, oxalic acid, tartaric acid, citric acid, lactic acid, fumaric acid, succinic acid, maleic acid, salicylic acid, benzoic acid, phenylacetic acid, mandelic acid and the like.
  • suitable pharmaceutically acceptable cation pairs for the carboxy group are well known to those skilled in the art and include alkaline, alkaline earth, ammonium, quaternary ammonium cations and the like.
  • pharmaceutically acceptable salts see infra and Berge et al., J. Pharm. Sci. 66:1 (1977).
  • leaving group generally refers to groups readily displaceable by a nucleophile, such as an amine, a thiol or an alcohol nucleophile. Such leaving groups are well known in the art. Examples of such leaving groups include, but are not limited to, N-hydroxysuccinimide, N-hydroxybenzotriazole, halides, triflates, tosylates and the like. Preferred leaving groups are indicated herein where appropriate.
  • Protecting group generally refers to groups well known in the art which are used to prevent selected reactive groups, such as carboxy, amino, hydroxy, mercapto and the like, from undergoing undesired reactions, such as nucleophilic, electrophilic, oxidation, reduction and the like. Preferred protecting groups are indicated herein where appropriate. Examples of amino protecting groups include, but are not limited to, aralkyl, substituted aralkyl, cycloalkenylalkyl and substituted cycloalkenyl alkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl, silyl and the like.
  • aralkyl examples include, but are not limited to, benzyl, ortho-methylbenzyl, trityl and benzhydryl, which can be optionally substituted with halogen, alkyl, alkoxy, hydroxy, nitro, acylamino, acyl and the like, and salts, such as phosphonium and ammonium salts.
  • aryl groups include phenyl, naphthyl, indanyl, anthracenyl, 9-(9-phenylfluorenyl), phenanthrenyl, durenyl and the like.
  • cycloalkenylalkyl or substituted cycloalkylenylalkyl radicals preferably have 6-10 carbon atoms, include, but are not limited to, cyclohexenyl methyl and the like.
  • Suitable acyl, alkoxycarbonyl and aralkoxycarbonyl groups include benzyloxycarbonyl, t-butoxycarbonyl, iso-butoxycarbonyl, benzoyl, substituted benzoyl, butyryl, acetyl, tri-fluoroacetyl, tri-chloro acetyl, phthaloyl and the like.
  • a mixture of protecting groups can be used to protect the same amino group, such as a primary amino group can be protected by both an aralkyl group and an aralkoxycarbonyl group.
  • Amino protecting groups can also form a heterocyclic ring with the nitrogen to which they are attached, for example, 1,2-bis(methylene)benzene, phthalimidyl, succinimidyl, maleimidyl and the like and where these heterocyclic groups can further include adjoining aryl and cycloalkyl rings.
  • the heterocyclic groups can be mono-, di- or tri-substituted, such as nitrophthalimidyl.
  • Amino groups may also be protected against undesired reactions, such as oxidation, through the formation of an addition salt, such as hydrochloride, toluenesulfonic acid, trifluoroacetic acid and the like.
  • an addition salt such as hydrochloride, toluenesulfonic acid, trifluoroacetic acid and the like.
  • Many of the amino protecting groups are also suitable for protecting carboxy, hydroxy and mercapto groups.
  • aralkyl groups are also suitable groups for protecting hydroxy and mercapto groups, such as tert-butyl.
  • Silyl protecting groups are silicon atoms optionally substituted by one or more alkyl, aryl and aralkyl groups. Suitable silyl protecting groups include, but are not limited to, trimethylsilyl, triethylsilyl, tri-isopropylsilyl, tert-butyldimethylsilyl, dimethylphenylsilyl, 1,2-bis(dimethylsilyl)benzene, 1,2-bis(dimethylsilyl)ethane and diphenylmethylsilyl.
  • Silylation of an amino groups provide mono- or di-silylamino groups. Silylation of aminoalcohol compounds can lead to a N,N,O-tri-silyl derivative.
  • silyl function from a silyl ether function is readily accomplished by treatment with, for example, a metal hydroxide or ammonium fluoride reagent, either as a discrete reaction step or in situ during a reaction with the alcohol group.
  • Suitable silylating agents are, for example, trimethylsilyl chloride, tert-butyl-dimethylsilyl chloride, phenyldimethylsilyl chloride, diphenylmethyl silyl chloride or their combination products with imidazole or DMF.
  • Methods for silylation of amines and removal of silyl protecting groups are well known to those skilled in the art.
  • Methods of preparation of these amine derivatives from corresponding amino acids, amino acid amides or amino acid esters are also well known to those skilled in the art of organic chemistry including amino acid/amino acid ester or aminoalcohol chemistry.
  • Protecting groups are removed under conditions which will not affect the remaining portion of the molecule. These methods are well known in the art and include acid hydrolysis, hydrogenolysis and the like. A preferred method involves removal of a protecting group, such as removal of a benzyloxycarbonyl group by hydrogenolysis utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof. A t-butoxycarbonyl protecting group can be removed utilizing an inorganic or organic acid, such as HCl or trifluoroacetic acid, in a suitable solvent system, such as dioxane or methylene chloride. The resulting amino salt can readily be neutralized to yield the free amine.
  • a protecting group such as removal of a benzyloxycarbonyl group by hydrogenolysis utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof.
  • a t-butoxycarbonyl protecting group can be removed utilizing an inorgan
  • Carboxy protecting group such as methyl, ethyl, benzyl, tert-butyl, 4-methoxyphenylmethyl and the like, can be removed under hydroylsis and hydrogenolysis conditions well known to those skilled in the art.
  • compounds of the invention may contain groups that may exist in tautomeric forms, such as cyclic and acyclic amidine and guanidine groups, heteroatom substituted heteroaryl groups (Y′ ⁇ O, S, NR), and the like, which are illustrated in the following examples: and though one form is named, described, displayed and/or claimed herein, all the tautomeric forms are intended to be inherently included in such name, description, display and/or claim.
  • groups that may exist in tautomeric forms such as cyclic and acyclic amidine and guanidine groups, heteroatom substituted heteroaryl groups (Y′ ⁇ O, S, NR), and the like, which are illustrated in the following examples: and though one form is named, described, displayed and/or claimed herein, all the tautomeric forms are intended to be inherently included in such name, description, display and/or claim.
  • Prodrugs of the compounds of this invention are also contemplated by this invention.
  • a prodrug is an active or inactive compound that is modified chemically through in vivo physiological action, such as hydrolysis, metabolism and the like, into a compound of this invention following administration of the prodrug to a patient.
  • the suitability and techniques involved in making and using prodrugs are well known by those skilled in the art.
  • For a general discussion of prodrugs involving esters see Svensson and Tunek Drug Metabolism Reviews 165 (1988) and Bundgaard Design of Prodrugs, Elsevier (1985).
  • Examples of a masked carboxylate anion include a variety of esters, such as alkyl (for example, methyl, ethyl), cycloalkyl (for example, cyclohexyl), aralkyl (for example, benzyl, p-methoxybenzyl), and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl).
  • esters such as alkyl (for example, methyl, ethyl), cycloalkyl (for example, cyclohexyl), aralkyl (for example, benzyl, p-methoxybenzyl), and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl).
  • Amines have been masked as arylcarbonyloxymethyl substituted derivatives which are cleaved by esterases in vivo releasing the free drug and formaldehyde (Bungaard J. Med. Chem. 2503 (1989
  • drugs containing an acidic NH group such as imidazole, imide, indole and the like, have been masked with N-acyloxymethyl groups (Bundgaard Design of Prodrugs, Elsevier (1985)). Hydroxy groups have been masked as esters and ethers.
  • EP 039,051 (Sloan and Little, Apr. 11, 1981) discloses Mannich-base hydroxamic acid prodrugs, their preparation and use.
  • Example 7(b) Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 6-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 7(b), (180 mg, 1.0 mmol) provided, after purification by silica gel chromatography (4:1 CH 2 Cl 2 :EtOAc), the title product as a pale yellow solid. MP 201-203° C. MS (ESI, pos. ion) m/z: 365 (M+1).
  • Example 9(b) Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 7-amino-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 9(b), (164 mg, 1.0 mmol) provided, after purification by silica gel chromatography (4:1 CH 2 Cl 2 :EtOAc), the title product as a pale yellow solid. MP 226-227° C. MS (ESI, pos. ion) m/z: 351 (M+1).
  • Example 9(a) 4-Methyl-7-nitro-2H-benzo[e]1,4-oxazaperhydroin-3-one. Analogous to the procedure used to prepare Example 7(a), 7-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 9(a), (970 mg, 25 mmol), benzyltrimethyl-ammonium chloride (110 mg, 0.50 mmol, Aldrich), iodomethane (0.47 mL, 7.5 mmol, Aldrich) and CsOH hydrate (4.2 g, 25 mmol, Aldrich), after purification by silica gel chromatography (9:1 hexane:EtOAc), provided the title product. MS (ESI, neg. ion) m/z: 207 (M ⁇ 1).
  • Example 11b Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 7-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 11b, (164 mg, 1.0 mmol) provided, after purification by silica gel chromatography (85:15 CH 2 Cl 2 :EtOAc), the title product as a pale yellow solid. MP 194-195° C. MS (ESI, pos. ion) m/z: 365 (M+1).
  • Example 11(b) Analogous to the procedure used for the preparation of Example 10, 7-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 11(b), (180 mg, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (85:15 CH 2 Cl 2 :EtOAc), the title product as a pale yellow solid. MP 232-233° C. MS (ESI, pos. ion) m/z: 351 (M+1).
  • Example 13(b) Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (1.3 g, 6.4 mmol, EMKA-Chemie) and ethyl 6-amino-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate, Example 13(b), (1.4 g, 6.4 mmol) provided, after purification by silica gel chromatography (85:15 CH 2 Cl 2 :EtOAc), the title product as a pale yellow solid. MP 207-208° C. MS (ESI, pos. ion) m/z: 409 (M+1).
  • Example 15 Analogous to the procedure described for Example 15, the title product was prepared starting from 2-hydroxy-4-nitrobenzaldehyde, Example 17(c), (R)-glycidyl tosylate (Aldrich) and 4-tert-butyl-trans-cinnamic acid (EMKA Chemie). MP 169-170° C. MS (ESI, pos. ion) m/z: 368 (M+1).
  • Example 27 (2E)-3-[4-(tert-butyl)phenyl]-N- ⁇ 3-[2-(1,3-dioxobenzo[c]azolin-2-yl)ethoxy]phenyl ⁇ prop-2-enamide, (856 mg, 1.83 mmol), EtOH (15 mL) and hydrazine (574 uL, 18.3 mmol, Aldrich). The reaction mixture was stirred at 25° C. for 2 h.
  • the resulting solution was purged with N 2 and treated with palladium (II) acetate (3.97 g, 17.7 mmol, Aldrich).
  • the reaction mixture was stirred in an oil bath at 80° C. for 15 h, then allowed to cool to 25° C. and filtered through a pad of Celite.
  • the Celite was washed with EtOAc and the combined filtrate was washed with satd NaHCO 3 (500 mL).
  • step (a) (2E)-3-[4-(tert-Butyl)phenyl]-2-methylprop-2-enoic acid.
  • step (a) triethyl 2-phosphonopropionate (2.4 g, 10 mmol, Aldrich) and 4-tert-butylbenzaldehyde (1.6 g, 10 mmol, Aldrich) provided the title product as a yellow solid.
  • MS (ESI, pos. ion) m/z: 219 (M+1).
  • step (a) (2E)-3-[4-(tert-Butyl)phenyl]-2-ethylprop-2-enoic acid.
  • step (a) triethyl 2-phosphonobutyrate (2.5 g, 10 mmol, Aldrich) and 4-tert-butylbenzaldehyde (1.6 g, 10 mmol, Aldrich) provided the title product as a white solid.
  • MS (ESI, pos. ion) m/z: 233 (M+1).
  • reaction mixture was stirred an additional 5 min at ⁇ 78° C., treated with triethylamine (2.0 mL, 14 mmol), allowed to warm to 25° C. and stirred at that temperature for 1 h.
  • the reaction was quenched by the addition of H 2 O and the mixture was extracted with Et 2 O. The organic extract was concentrated in vacuo to provide 230 mg (95% over two steps) of the title product.
  • reaction mixture was magnetically stirred and treated with a solution of ammonium persulfate (9.1 g, 40 mmol, Aldrich) in H 2 O (40 mL). Evolution of gas was observed and the reaction mixture was stirred at 25° C. for 2 h.
  • the reaction mixture was basified to pH 9 by the addition of aq. ammonium hydroxide then extracted with EtOAc. The organic extract was washed with H 2 O, dried over Na 2 SO 4 , filtered and concentrated in vacuo. Purification of the crude product by silica gel chromatography (70:30 hexane:EtOAc) provided the title product.

Abstract

Compounds having the general structure
Figure US20060030618A1-20060209-C00001
 and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

Description

  • The present invention is a divisional and claims the benefit of U.S. application Ser. No. 10/316,295 filed on Dec. 10, 2002, U.S. Provisional Application Nos. 60/339,161 filed Dec. 10, 2001, 60/344,737, filed Dec. 21, 2001, 60/383,331, filed May 22, 2002 and 60/402,422, filed Aug. 8, 2002, which are hereby incorporated by reference.
    • BACKGROUND
  • The vanilloid receptor 1 (VR1) is the molecular target of capsaicin, the active ingredient in hot peppers. Julius et al. reported the molecular cloning of VR1 (Caterina et al., 1997). VR1 is a non-selective cation channel which is activated or sensitized by a series of different stimuli including capsaicin and resiniferatoxin (exogenous activators), heat & acid stimulation and products of lipid bilayer metabolism, anandamide (Premkumar et al., 2000, Szabo et al., 2000, Gauldie et al., 2001, Olah et al., 2001) and lipoxygenase metabolites (Hwang et al., 2000). VR1 is highly expressed in primary sensory neurons (Caterina et al., 1997) in rats, mice and humans (Onozawa et al., 2000, Mezey et al., 2000, Helliwell et al., 1998, Cortright et al., 2001). These sensory neurons innervate many visceral organs including the dermis, bones, bladder, gastrointestinal tract and lungs; VR1 is also expressed in other neuronal and non-neuronal tissues including but not limited to, CNS nuclei, kidney, stomach and T-Cells (Nozawa et al., 2001, Yiangou et al., 2001, Birder et al., 2001). Presumably expression in these various cells and organs may contribute to their basic properties such as cellular signaling and cell division.
  • Prior to the molecular cloning of VR1, experimentation with capsaicin indicated the presence of a capsaicin sensitive receptor, which could increase the activity of sensory neurons in humans, rats and mice (Holzer, 1991; Dray, 1992, Szallasi and Blumberg 1996, 1999). The results of acute activation by capsaicin in humans was pain at injection site and in other species increased behavioral sensitivity to sensory stimuli (Szallasi and Blumberg, 1999). Capsaicin application to the skin in humans causes a painful reaction characterized not only by the perception of heat and pain at the site of administration but also by a wider area of hyperalgesia and allodynia, two characteristic symptoms of the human condition of neuropathic pain (Holzer, 1991). Taken together, it seems likely that increased activity of VR1 plays a significant role in the establishment and maintenance of pain conditions. Topical or intradermal injection of capsaicin has also been shown to produce localized vasodilation and edema production (Szallasi and Blumberg 1999, Singh et al., 2001). This evidence indicates that capsaicin through it's activation of VR1 can regulate afferent and efferent function of sensory nerves. Sensory nerve involvement in diseases could therefore be modified by molecules which effect the function of the vanilloid receptor to increase or decrease the activity of sensory nerves.
  • VR1 gene knockout mice have been shown to have reduced sensory sensitivity to thermal and acid stimuli (Caterina et al., 2000)). This supports the concept that VR1 contributes not only to generation of pain responses (i.e. via thermal, acid or capsaicin stimuli) but also to the maintenance of basal activity of sensory nerves. This evidence agrees with studies demonstrating capsaicin sensitive nerve involvement in disease. Primary sensory nerves in humans and other species can be made inactive by continued capsaicin stimulation. This paradigm causes receptor activation induced desensitization of the primary sensory nerve—such reduction in sensory nerve activity in vivo makes subjects less sensitive to subsequent painful stimuli. In this regard both capsaicin and resinferatoxin (exogenous activators of VR1), produce desensitization and they have been used for many proof of concept studies in in vivo models of disease (Holzer, 1991, Dray 1992, Szallasi and Blumberg 1999).
  • VR1 agonists or antagonists have use as analgesics for the treatment of pain of various genesis or aetiology, for example acute, inflammatory and neuropathic pain, dental pain and headache, particularly vascular headache such as migraine, cluster headache and mixed vascular syndromes as well as non-vascular, tension headache. They are also useful as anti-inflammatory agents for the treatment of inflammatory diseases or conditions, for example the treatment of arthritis and rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders (e.g. uvetis), inflammatory or unstable bladder disorders (e.g. cystitis and urinary incontinence), psoriasis and skin complaints with inflammatory components, as well as other chronic inflammatory conditions. They are, in particular, useful in the treatment of inflammatory pain and associated hyperalgesia and allodynia. They are also useful in the treatment of neuropathic pain and associated hyperalgesia and allodynia, e.g. trigeminal or herpetic neuralgia, diabetic neuropathy pain, causalgia, sympathetically maintained pain and deafferentation syndromes such as brachial plexus avulsion. They are also indicated for the use in the prophylactic or curative treatment of asthma, of epithelial tissue damage or dysfunction, e.g. spontaneous lesions, of herpes simplex, and in the control of disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular e.g. for treating wounds, burns, allergic skin reactions, pruritis and vitiligo, for the prophylactic or curative treatment of gastrointestinal disorders such as gastric ulceration, duodenal ulcers, inflammatory bowel disease and diarrhea, gastric lesions induced by necrotising agents, for example ethanol or chemotherapeutic agents, hair growth, for the treatment of vasomotor or allergic rhinitis and for the treatment of bronchial disorders or bladder disorders, such as bladder hyper-reflexia.
    • BIBLIOGRAPHY
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    • Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., and Julius, D, (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389: 816-824.
    • Caterina-M J. Leffler-A. Malmberg-A B. Martin-W J. Trafton-J. Petersen-Zeitz K R. Koltzenburg-M. Basbaum-A I. Julius-D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science-(Washington, D.C.). 288: 5464: 306-313.
    • Cortright-D N. Crandall-M. Sanchez-J F. Zou-T. Krause-J E. White-G (2001) The tissue distribution and functional characterization of human VR1. Biochemical and Biophysical Research Communications 281: 5: 1183-1189
    • Dray, A., (1992). Therapeutic potential of capsaicin-like molecules. Life Sciences 51: 1759-1765.
    • Gauldie-S D. McQueen-D S. Pertwee-R. Chessell-I P. (2001) Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. British Journal of Pharmacology 132: 3: 617-621.
    • Helliwell-R J A. McLatchie-L M. Clarke-M. Winter-J. Bevan-S. McIntyre-P (1998) Capsaicin sensitivity is associated with expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia. Neuroscience Lett. 250: 3: 177-180.
    • Holzer, P. (1991) Capsaicin: Cellular targets, Mechanisms of Action and selectivity for thin sensory neurons. Pharmacological reviews 43: 2: 143-201
    • Hwang-S W. Cho-H. Kwak-J. Lee-S Y. Kang-C J. Jung-J. Cho-S. Min-K H. Suh-Y G. Kim-D. Oh-U. (2000) Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances. PNAS97: 11: 6155-6160.
    • Mezey-E. Toth-Z E. Cortright-D N. Arzubi-M K. Krause-J E. Elde-R. Guo-A. Blumberg-P M. Szallasi-A (2000) Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human. PNAS 97: 7: 3655-3660.
    • Nozawa-Y. Nishihara-K. Yamamoto-A. Nakano-M. Ajioka-H. Matsuura-N. (2001) Distribution and characterization of vanilloid receptors in the rat stomach. Neuroscience Letters 309: 1: 33-36.
    • Olah-Z. Karai-L. Iadarola-M J. (2001) Anandamide activates vanilloid receptor 1 (VR1) at acidic pH in dorsal root ganglia neurons and cells ectopically expressing VR1. Journal of Biological Chemistry 276: 33, 31163-31170.
    • Onozawa-K. Nakamura-A. Tsutsumi-S. Yao-J. Ishikawa-R. Kohama-K. (2000) Tissue distribution of capsaicin receptor in the various organs of rats. Proc. Jpn. Acad. Ser. B, Phys.-Biol. Sci. 76: 5: 68-72.
    • Premkumar-L S. Ahern-G P. (2000) Induction of vanilloid receptor channel activity by protein kinase C. Nature (London) 408: 6815: 985-990.
    • Singh-L K. Pang-X. Alexacos-N. Letourneau-R. Theoharides-T C. (1999) Acute immobilization stress triggers skin mast cell degranulation via corticotropin releasing hormone, neurotensin, and substance P: A link to neurogenic skin disorders. Brain Behav. Immun. 13: 3: 225-239.
    • Szallasi, A. Blumberg-P M (1996) Vanilloid receptors: New insights enhance potential as a therapeutic target. Pain 68: 195-208
    • Szallasi-A. Blumberg-P M. (1999) Vanilloid (capsaicin) receptors and mechanisms. Pharmacol. Rev. 51: 2: 159-211.
    • Szabo-T. Wang-J. Gonzalez-A. Kedei-N. Lile-J. Treanor-J. Blumberg-P M. (2000) Pharmacological characterization of the human vanilloid receptor type-1 (hVR1). Society for Neuroscience Abstracts. 26:1-2: 634.18.
    • Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., and Julius, D., (1998). The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21: 531-543.
    • Yiangou-Y. Facer-P. Dyer-N H C. Chan-C L H. Knowles-C. Williams-N S. Anand-P. (2001) Vanilloid receptor 1 immunoreactivity in inflamed human bowel. Lancet (North American Edition) 357: 9265: 1338-1339.
    • Yiangou-Y. Facer-P. Ford-A. Brady-C. Wiseman-O. Fowler-C J. Anand-P. (2001) Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU International 87: 9: 774-779.
    • Wang-H. Bian-D. Zhu-D. Zajic-G. Loeloff-R. Lile-J. Wild-K. Treanor-J. Curran-E. (2000) Inflammation-induced upregulation of VR1 in rat spinal cord and DRG correlates with enhanced nociceptive processing. Society for Neuroscience Abstracts 26:1-2: 632.15.
    SUMMARY
  • The present invention comprises a new class of compounds useful in the treatment of diseases, such as vanilloid-receptor-mediated diseases and other maladies, such as inflammatory or neuropathic pain and diseases involving sensory nerve function such as asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis. In particular, the compounds of the invention are useful for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders. Analogously, the invention also comprises pharmaceutical compositions comprising the compounds, methods for the treatment of vanilloid-receptor-mediated diseases, such as inflammatory or neuropathic pain, asthma, rheumatoid arthritis, osteoarthritis, inflammatory bowel disorders, urinary incontinence, migraine and psoriasis diseases, using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of the compounds of the invention.
  • The compounds of the invention are represented by the following general structure
    Figure US20060030618A1-20060209-C00002
    or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, X and Y are defined below.
  • The foregoing merely summarizes certain aspects of the invention and is not intended, nor should it be construed, as limiting the invention in any way. All patents, patent applications and other publications recited herein are hereby incorporated by reference in their entirety.
    • DETAILED DESCRIPTION
  • One aspect of the current invention relates to compounds having the general structure:
    Figure US20060030618A1-20060209-C00003
    wherein:
  • R1 is
    Figure US20060030618A1-20060209-C00004
    or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
  • R2 is H, hydroxy, halo, C1-6alkyl substituted by 0, 1 or 2 substituents selected from R10,
    Figure US20060030618A1-20060209-C00005
    or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7; or R1 and R2 together are
    Figure US20060030618A1-20060209-C00006
  • R3 is H or C1-4alkyl; or R1 and R3 together are
    Figure US20060030618A1-20060209-C00007
  • R4 is
    Figure US20060030618A1-20060209-C00008
    R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl and —NRaC(═O)C1-6alkyl; or R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O; except that when R1 is 4-Chlorophenyl, 3-bromophenyl, 3-nitrophenyl, 2-nitro-3-Chlorophenyl, 3,4-methylenedioxyphenyl, 3-methylthiophenyl or 2,3,4-methoxyphenyl, then R4 is not phenyl substituted by 1 or 2 substituents selected from halo and C1-4alkyl; and R1 and R4 are not both 3,4-methylenedioxyphenyl; and when R1 is 4-trifluoromethylphenyl, then R4 is not pyridinyl, 2-methyl-4-aminoquinolinyl or 3,3-dimethyl-1,3-dihydroindol-2-on-6-yl;
  • R5 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRaC1-6alkylORa; or R5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S;
  • R6 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa or —NRaC1-6alkylORa; or R5 and R6 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C1-6alkyl, (═O), —OC1-6alkyl, —NRaC1-6alkyl, —C1-6alkylORa and C1-6alkylNRaRa, and the available N atoms of the bridge are substituted by Ra, —C1-6alkylORa or C1-6alkylNRaRa;
  • R7 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRa—C1-6alkylORa;
  • R8 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa or —NRaC1-6alkylORa; or R7 and R8 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C1-6alkyl, (═O), —O—C1-6alkyl, —NRaC1-6alkyl, —C1-6alkylORa and C1-6alkylNRaRa, and the available N atoms of the bridge are substituted by Ra, —C1-6alkylORa or C1-6alkylNRaRa;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, 'OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRaC1-4haloalkyl, —NRaC1-6alkylNRaRa or —NRa—C1-6alkylORa;
  • R10 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R11 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R10 and R11 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc; wherein if R10, R12, R13 and R14 are all H, then R11 is not —O—C1-6alkylNRaRa or —O—C1-6alkylORa;
  • R12 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R11 and R12 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • when R1 is 4-C1-6alkylphenyl or 2,4-dimethylphenyl, then R11 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R10 and R11 together are -L3-NRa—, respectively, or -L4-O—, respectively; or R11 and R12 are —NRa-L3-, -L3—NRa—, —O-L4- or -L4-O—; or R12 is —NRaRb; or R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O; or R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 1, 2 or 3 substituents independently selected from C2-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl and —NRaC(═O)C1-6alkyl;
  • R13 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R14 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • Ra is independently, at each instance, H, phenyl, benzyl or C1-6alkyl;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra;
  • Rc is phenyl substituted by 0, 1 or 2 groups selected from halo, C1-3haloalkyl, —ORa and —NRaRa; or Rc is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-3haloalkyl, —ORa and —NRaRa;
  • L1 is a bond, —CH2CH2— or —CH═CH—;
  • L2 is NRa, O, S(═O)n, —N═CH—, —CH2NRa—, —CH═N— or —NRaCH2—;
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • L4 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein at least one of the carbon atoms in the bridge is substituted by ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)OC1-6alkyl, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaC1-6alkyl, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • X is O, S or NRa; or X and R2 together are ═N—CH═CH—, ═C—O—, ═C—S—, or ═C—NRa—;
  • Y is NH or O; and
  • n is independently, at each instance, 0, 1 or 2; with the proviso that when R1 is 4-chlorophenyl, then R4 is not 3-methoxyphenyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00009
    or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
  • R2 is H, hydroxy, halo, C1-6alkyl substituted by 0, 1 or 2 substituents selected from R10,
    Figure US20060030618A1-20060209-C00010
    or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7; and
  • R3 is H or C1-4alkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00011
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is independently, at each instance, C2-9alkyl or C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is
    Figure US20060030618A1-20060209-C00012
    or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is
    Figure US20060030618A1-20060209-C00013
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 and R2 together are
    Figure US20060030618A1-20060209-C00014
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 and R3 together are
    Figure US20060030618A1-20060209-C00015
  • In another embodiment, in conjunction with the novel compound embodiments above and below, X and R together are ═N—CH═CH—, ═C—O—, ═C—S—, or ═C—NRa—.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00016
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
  • Y2 is —NRa— or —O—.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00017
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
  • Y2 is —NRb— or —O—.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00018
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
  • Y2 is —NRb— or —O—.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00019
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
  • Y2 is —NRb— or —O—.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00020
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6—O—Ra; and
  • Y2 is —NRa— or —O—.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00021
  • R10 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R11 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; C1-6alkylNRaRa;
  • R12 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R13 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; and
  • R14 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; wherein one of R10 and R12 is not H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4haloalkyl, —ORa and —NRaRa.
  • Another aspect of the invention relates to a compound having the structure:
    Figure US20060030618A1-20060209-C00022
    or any pharmaceutically-acceptable salt thereof, wherein:
  • n is independently, at each instance, 0, 1 or 2.
  • R1 is
    Figure US20060030618A1-20060209-C00023
    or R1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R5; or R1 is Re substituted by 1, 2 or 3 substituents independently selected from R5;
  • R15 is, independently, in each instance, R10, C1-8alkyl substituted by 0, 1 or 2 substituents selected from R10, —(CH2)nphenyl substituted by 0, 1, 2 or 3 substituents independently selected from R10, or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R10;
  • R16 is, independently, in each instance, H, halo, —NH2, —NHC1-3alkyl, —N(C1-3alkyl)C1-3alkyl or C1-3alkyl;
  • R4 is
    Figure US20060030618A1-20060209-C00024
    R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, oxo, —ORd, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —OC1-6alkylC(═O)ORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRdC1-6alkyl and —NRdC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf; or R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORd, NRdRd, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O; but in no instance is R4 3,5-ditrifluoromethylphenyl or 3-trifluoromethyl-4-fluorophenyl;
  • R5 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, naphthyl, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRdRd, —NRdC(═O)Rd, —NRdC(═O)NRdRd, —NRdCO2(C1-6alkyl), —C1-8alkylORd, —C1-6alkylNRdRd, —S(═O)n(C1-6alkyl), —S(═O)2NRdRd, —NRdS(═O)2(C1-6alkyl), —OC(═O)NRdRd, a phenyl ring substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R6 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd or NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd, —S(C1-6alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R10; or R6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R7 is independently, at each instance, H, C1-8alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd or —S(C1-6alkyl); or R7 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl;
  • R8 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd or —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd, —S(C1-6alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R10, or R8 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R9 is independently, at each instance, H, C1-8alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd or —NRdC2-6alkylORd, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRdRd, —NRdC(═O)(C1-6alkyl), —NRdC(═O)NRdRd, —NRdCO2(C1-6alkyl), —C1-8alkylORd, —C1-6alkylNRdRd, —S(═O)n(C1-6alkyl), —S(═O)2NRdRd, —NRdS(═O)2(C1-6alkyl), —OC(═O)NRdRd, a phenyl ring substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R9 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R9 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl; wherein at least one of R5, R6, R7, R8 and R9 is C1-8alkyl, C1-4haloalkyl, halo, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd or —S(C1-6alkyl);
  • R10 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd;
  • R11 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R11 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R11 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 and R11 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf;
  • R12 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R12 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R12 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; wherein if R11 or R13 is CF3, then R12 is not F; or R11 and R12 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf;
  • R13 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R13 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R13 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd;
  • R14 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R14 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R14 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd;
  • Rd is independently, at each instance, H, phenyl, benzyl or C1-6alkyl;
  • Re is a heterocycle selected from the group of thiophene, pyrrole, 1,3-oxazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, 1H-1,2,3-triazole, isothiazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole, 1,2,3,4-oxatriazole, 1,2,3,4-thiatriazole, 1H-1,2,3,4-tetraazole, 1,2,3,5-oxatriazole, 1,2,3,5-thiatriazole, furan, imidazol-1-yl, imidazol-4-yl, 1,2,4-triazol-4-yl, 1,2,4-triazol-5-yl, isoxazol-3-yl, isoxazol-5-yl, pyrazol-3-yl, pyrazol-5-yl, thiolane, pyrrolidine, tetrahydrofuran, 4,5-dihydrothiophene, 2-pyrroline, 4,5-dihydrofuran, pyridazine, pyrimidine, pyrazine, 1,2,3-triazine, 1,2,4-triazine, 1,2,4-triazine, 1,3,5-triazine, pyridine, 2H-3,4,5,6-tetrahydropyran, thiane, 1,2-diazaperhydroine, 1,3-diazaperhydroine, piperazine, 1,3-oxazaperhydroine, morpholine, 1,3-thiazaperhydroine, 1,4-thiazaperhydroine, piperidine, 2H-3,4-dihydropyran, 2,3-dihydro-4H-thiin, 1,4,5,6-tetrahydropyridine, 2H-5,6-dihydropyran, 2,3-dihydro-6H-thiin, 1,2,5,6-tetrahydropyridine, 3,4,5,6-tetrahydropyridine, 4H-pyran, 4H-thiin, 1,4-dihydropyridine, 1,4-dithiane, 1,4-dioxane, 1,4-oxathiane, 1,2-oxazolidine, 1,2-thiazolidine, pyrazolidine, 1,3-oxazolidine, 1,3-thiazolidine, imidazolidine, 1,2,4-oxadiazolidine, 1,3,4-oxadiazolidine, 1,2,4-thiadiazolidine, 1,3,4-thiadiazolidine, 1,2,4-triazolidine, 2-imidazoline, 3-imidazoline, 2-pyrazoline, 4-imidazoline, 2,3-dihydroisothiazole, 4,5-dihydroisoxazole, 4,5-dihydroisothiazole, 2,5-dihydroisoxazole, 2,5-dihydroisothiazole, 2,3-dihydroisoxazole, 4,5-dihydrooxazole, 2,3-dihydrooxazole, 2,5-dihydrooxazole, 4,5-dihydrothiazole, 2,3-dihydrothiazole, 2,5-dihydrothiazole, 1,3,4-oxathiazolidine, 1,4,2-oxathiazolidine, 2,3-dihydro-1H-[1,2,3]triazole, 2,5-dihydro-1H-[1,2,3]triazole, 4,5-dihydro-1H-[1,2,3]triazole, 2,3-dihydro-1H-[1,2,4]triazole, 4,5-dihydro-1H-[1,2,4]triazole, 2,3-dihydro-[1,2,4]oxadiazole, 2,5-dihydro-[1,2,4]oxadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,2,4]thidiazole, 2,5-dihydro-[1,2,4]thiadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,5-dihydro-[1,2,4]oxadiazole, 2,3-dihydro-[1,2,4]oxadiazole, 4,5-dihydro-[1,2,4]oxadiazole, 2,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,2,4]thiadiazole, 4,5-dihydro-[1,2,4] thiadiazole, 2,3-dihydro-[1,3,4]oxadiazole, 2,3-dihydro-[1,3,4]thiadiazole, [1,4,2]oxathiazole, [1,3,4]oxathiazole, 1,3,5-triazaperhydroine, 1,2,4-triazaperhydroine, 1,4,2-dithiazaperhydroine, 1,4,2-dioxazaperhydroine, 1,3,5-oxadiazaperhydroine, 1,2,5-oxadiazaperhydroine, 1,3,4-thiadiazaperhydroine, 1,3,5-thiadiazaperhydroine, 1,2,5-thiadiazaperhydroine, 1,3,4-oxadiazaperhydroine, 1,4,3-oxathiazaperhydroine, 1,4,2-oxathiazaperhydroine, 1,4,5,6-tetrahydropyridazine, 1,2,3,4-tetrahydropyridazine, 1,2,3,6-tetrahydropyridazine, 1,2,5,6-tetrahydropyrimidine, 1,2,3,4-tetrahydropyrimidine, 1,4,5,6-tetrahydropyrimidine, 1,2,3,6-tetrahydropyrazine, 1,2,3,4-tetrahydropyrazine, 5,6-dihydro-4H-[1,2]oxazine, 5,6-dihydro-2H-[1,2]oxazine, 3,6-dihydro-2H-[1,2]oxazine, 3,4-dihydro-2H-[1,2]oxazine, 5,6-dihydro-4H-[1,2]thiazine, 5,6-dihydro-2H-[1,2]thiazine, 3,6-dihydro-2H-[1,2]thiazine, 3,4-dihydro-2H-[1,2]thiazine, 5,6-dihydro-2H-[1,3]oxazine, 5,6-dihydro-4H-[1,3]oxazine, 3,6-dihydro-2H-[1,3]oxazine, 3,4-dihydro-2H-[1,3]oxazine, 3,6-dihydro-2H-[1,4]oxazine, 3,4-dihydro-2H-[1,4]oxazine, 5,6-dihydro-2H-[1,3]thiazine, 5,6-dihydro-4H-[1,3]thiazine, 3,6-dihydro-2H-[1,3]thiazine, 3,4-dihydro-2H-[1,3]thiazine, 3,6-dihydro-2H-[1,4]thiazine, 3,4-dihydro-2H-[1,4]thiazine, 1,2,3,6-tetrahydro-[1,2,4]triazine, 1,2,3,4-tetrahydro-[1,2,4]triazine, 1,2,3,4-tetrahydro-[1,3,5]triazine, 2,3,4,5-tetrahydro-[1,2,4]triazine, 1,4,5,6-tetrahydro-[1,2,4]triazine, 5,6-dihydro-[1,4,2]dioxazine, 5,6-dihydro-[1,4,2]dioxazine, 5,6-dihydro-[1,4,2]dithiazine, 2,3-dihydro-[1,4,2]dioxazine, 3,4-dihydro-2H-[1,3,4]oxadiazine, 3,6-dihydro-2H-[1,3,4]oxadiazine, 3,4-dihydro-2H-[1,3,5]oxadiazine, 3,6-dihydro-2H-[1,3,5]oxadiazine, 5,6-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-4H-[1,2,5]oxadiazine, 3,4-dihydro-2H-[1,3,4]thiadiazine, 3,6-dihydro-2H-[1,3,4]thiadiazine, 3,4-dihydro-2H-[1,3,5]thiadiazine, 3,6-dihydro-2H-[1,3,5]thiadiazine, 5,6-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-4H-[1,2,5]thiadiazine, 5,6-dihydro-2H-[1,2,3]oxadiazine, 3,6-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-4H-[1,3,4]oxadiazine, 3,4-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-2H-[1,2,3]thiadiazine, 3,6-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-4H-[1,3,4]thiadiazine, 3,4-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-[1,4,3]oxathiazine, 5,6-dihydro-[1,4,2]oxathiazine, 2,3-dihydro-[1,4,3]oxathiazine, 2,3-dihydro-[1,4,2]oxathiazine, 4,5-dihydropyridine, 1,6-dihydropyridine, 5,6-dihydropyridine, 2H-pyran, 2H-thiin, 3,6-dihydropyridine, 2,3-dihydropyridazine, 2,5-dihydropyridazine, 4,5-dihydropyridazine, 1,2-dihydropyridazine, 2,3-dihydropyrirnidine, 2,5-dihydropyrirnidine, 5,6-dihydropyrirnidine, 3,6-dihydropyrirnidine, 4,5-dihydropyrazine, 5,6-dihydropyrazine, 3,6-dihydropyrazine, 4,5-dihydropyrazine, 1,4-dihydropyrazine, 1,4-dithiin, 1,4-dioxin, 2H-1,2-oxazine, 6H-1,2-oxazine, 4H-1,2-oxazine, 2H-1,3-oxazine, 4H-1,3-oxazine, 6H-1,3-oxazine, 2H-1,4-oxazine, 4H-1,4-oxazine, 2H-1,3-thiazine, 2H-1,4-thiazine, 4H-1,2-thiazine, 6H-1,3-thiazine, 4H-1,4-thiazine, 2H-1,2-thiazine, 6H-1,2-thiazine, 1,4-oxathiin, 2H,5H-1,2,3-triazine, 1H,4H-1,2,3-triazine, 4,5-dihydro-1,2,3-triazine, 1H,6H-1,2,3-triazine, 1,2-dihydro-1,2,3-triazine, 2,3-dihydro-1,2,4-triazine, 3H,6H-1,2,4-triazine, 1H,6H-1,2,4-triazine, 3,4-dihydro-1,2,4-triazine, 1H,4H-1,2,4-triazine, 5,6-dihydro-1,2,4-triazine, 4,5-dihydro-1,2,4-triazine, 2H,5H-1,2,4-triazine, 1,2-dihydro-1,2,4-triazine, 1H,4H-1,3,5-triazine, 1,2-dihydro-1,3,5-triazine, 1,4,2-dithiazine, 1,4,2-dioxazine, 2H-1,3,4-oxadiazine, 2H-1,3,5-oxadiazine, 6H-1,2,5-oxadiazine, 4H-1,3,4-oxadiazine, 4H-1,3,5-oxadiazine, 4H-1,2,5-oxadiazine, 2H-1,3,5-thiadiazine, 6H-1,2,5-thiadiazine, 4H-1,3,4-thiadiazine, 4H-1,3,5-thiadiazine, 4H-1,2,5-thiadiazine, 2H-1,3,4-thiadiazine, 6H-1,3,4-thiadiazine, 6H-1,3,4-oxadiazine and 1,4,2-oxathiazine, wherein the heterocycle is optionally vicinally fused with a saturated or unsaturated 5-, 6- or 7-membered ring containing 0, 1 or 2 atoms independently selected from N, O and S;
  • Rf is phenyl substituted by 0, 1 or 2 groups selected from halo, C1-4alkyl, C1-3haloalkyl, —ORd and —NRdRd; or Rf is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4alkyl, C1-3haloalkyl, —ORd and —NRdRd; and
  • Rg is hydrogen or —CH3.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R16 is halo, —NH2, —NHC1-3alkyl, —N(C1-3alkyl)C1-3alkyl or C1-3alkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R10 is independently, at each instance, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00025
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-5alkyl, halo or C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is Re substituted by 0, 1, 2 or 3 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is Re substituted by 1, 2 or 3 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00026
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R10 and R11 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf; or
  • R11 and R12 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, oxo, —ORd, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —OC1-6alkylC(═O)ORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRdC1-6alkyl and —NR C(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, oxo, —ORd, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —OC1-6alkylC(═O)ORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRdC1-6alkyl and —NRdC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORd, —C1-6alkyl, —C1-6alkylNRdRd, —C1-3alkylC(═O)ORd, —C1-3alkylC(═O)NRdRd, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRdC(═O)C1-6alkyl, —C(═O)Rf or —C1-3alkylRf.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORd, NRdRd, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORd, NRdRd, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O.
  • Another aspect of the invention relates to a compound having the structure:
    Figure US20060030618A1-20060209-C00027
    or any pharmaceutically-acceptable salt thereof, wherein:
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Y is NH, O or S;
  • R1 is
    Figure US20060030618A1-20060209-C00028
    or R1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R5; or R1 is Re substituted by 1, 2 or 3 substituents independently selected from R5;
  • R15 is, independently, in each instance, R10, C1-8alkyl substituted by 0, 1 or 2 substituents selected from R10, —(CH2)nphenyl substituted by 0, 1, 2 or 3 substituents independently selected from R10, or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R10;
  • R16 is, independently, in each instance, H, halo, —NH2, —NHC1-3alkyl, —N(C1-3alkyl)C1-3alkyl or C1-3alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)R5, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups; but in no instance is R4 3,5-ditrifluoromethylphenyl or 3-trifluoromethyl-4-fluorophenyl;
  • R5 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, naphthyl, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRdRd, —NRdC(═O)Rd, —NRdC(═O)NRdRd, —NRdCO2(C1-6alkyl), —C1-8alkylORd, —C1-6alkylNRdRd, —S(═O)n(C1-6alkyl), —S(═O)2NRdRd, —NRdS(═O)2(C1-6alkyl), —OC(═O)NRdRd, a phenyl ring substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R6 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd or —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd, —S(C1-6alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R10; or R6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R7 is independently, at each instance, H, C1-8alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd or —S(C1-6alkyl); or R7 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl;
  • R8 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd, —S(C1-6alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R10, or R6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R9 is independently, at each instance, H, C1-8alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd or —NRdC2-6alkylORd, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRdRd, —NRdC(═O)(C1-6alkyl), —NRdC(═O)NRdRd, —NRdCO2(C1-6alkyl), —C1-8alkylORd, —C1-6alkylNRdRd, —S(═O)n(C1-6alkyl), —S(═O)2NRdRd, —NRdS(═O)2(C1-6alkyl), —OC(═O)NRdRd or a —(CRqRq)ophenyl wherein the phenyl is substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R9 is —(CRqRq)oHet wherein Het is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R9 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl; wherein at least one of R5, R6, R7, R8 and R9 is C1-8alkyl, C1-4haloalkyl, halo, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd, —NRdC2-6alkylORd, —C1-8alkylORd, —C1-6alkylNRdRd or —S(C1-6alkyl);
  • R10 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylOR or R10 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd;
  • Rd is independently, at each instance, H, phenyl, benzyl or C1-6alkyl;
  • Re is a heterocycle selected from the group of thiophene, pyrrole, 1,3-oxazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, 1H-1,2,3-triazole, isothiazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole, 1,2,3,4-oxatriazole, 1,2,3,4-thiatriazole, 1H-1,2,3,4-tetraazole, 1,2,3,5-oxatriazole, 1,2,3,5-thiatriazole, furan, imidazol-1-yl, imidazol-4-yl, 1,2,4-triazol-4-yl, 1,2,4-triazol-5-yl, isoxazol-3-yl, isoxazol-5-yl, pyrazol-3-yl, pyrazol-5-yl, thiolane, pyrrolidine, tetrahydrofuran, 4,5-dihydrothiophene, 2-pyrroline, 4,5-dihydrofuran, pyridazine, pyrimidine, pyrazine, 1,2,3-triazine, 1,2,4-triazine, 1,2,4-triazine, 1,3,5-triazine, pyridine, 2H-3,4,5,6-tetrahydropyran, thiane, 1,2-diazaperhydroine, 1,3-diazaperhydroine, piperazine, 1,3-oxazaperhydroine, morpholine, 1,3-thiazaperhydroine, 1,4-thiazaperhydroine, piperidine, 2H-3,4-dihydropyran, 2,3-dihydro-4H-thiin, 1,4,5,6-tetrahydropyridine, 2H-5,6-dihydropyran, 2,3-dihydro-6H-thiin, 1,2,5,6-tetrahydropyridine, 3,4,5,6-tetrahydropyridine, 4H-pyran, 4H-thiin, 1,4-dihydropyridine, 1,4-dithiane, 1,4-dioxane, 1,4-oxathiane, 1,2-oxazolidine, 1,2-thiazolidine, pyrazolidine, 1,3-oxazolidine, 1,3-thiazolidine, imidazolidine, 1,2,4-oxadiazolidine, 1,3,4-oxadiazolidine, 1,2,4-thiadiazolidine, 1,3,4-thiadiazolidine, 1,2,4-triazolidine, 2-imidazoline, 3-imidazoline, 2-pyrazoline, 4-imidazoline, 2,3-dihydroisothiazole, 4,5-dihydroisoxazole, 4,5-dihydroisothiazole, 2,5-dihydroisoxazole, 2,5-dihydroisothiazole, 2,3-dihydroisoxazole, 4,5-dihydrooxazole, 2,3-dihydrooxazole, 2,5-dihydrooxazole, 4,5-dihydrothiazole, 2,3-dihydrothiazole, 2,5-dihydrothiazole, 1,3,4-oxathiazolidine, 1,4,2-oxathiazolidine, 2,3-dihydro-1H-[1,2,3]triazole, 2,5-dihydro-1H-[1,2,3]triazole, 4,5-dihydro-1H-[1,2,3]triazole, 2,3-dihydro-1H-[1,2,4]triazole, 4,5-dihydro-1H-[1,2,4]triazole, 2,3-dihydro-[1,2,4]oxadiazole, 2,5-dihydro-[1,2,4]oxadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,2,4]thidiazole, 2,5-dihydro-[1,2,4]thiadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,5-dihydro-[1,2,4]oxadiazole, 2,3-dihydro-[1,2,4]oxadiazole, 4,5-dihydro-[1,2,4]oxadiazole, 2,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,2,4]thiadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,3,4]oxadiazole, 2,3-dihydro-[1,3,4]thiadiazole, [1,4,2]oxathiazole, [1,3,4]oxathiazole, 1,3,5-triazaperhydroine, 1,2,4-triazaperhydroine, 1,4,2-dithiazaperhydroine, 1,4,2-dioxazaperhydroine, 1,3,5-oxadiazaperhydroine, 1,2,5-oxadiazaperhydroine, 1,3,4-thiadiazaperhydroine, 1,3,5-thiadiazaperhydroine, 1,2,5-thiadiazaperhydroine, 1,3,4-oxadiazaperhydroine, 1,4,3-oxathiazaperhydroine, 1,4,2-oxathiazaperhydroine, 1,4,5,6-tetrahydropyridazine, 1,2,3,4-tetrahydropyridazine, 1,2,3,6-tetrahydropyridazine, 1,2,5,6-tetrahydropyrimidine, 1,2,3,4-tetrahydropyrimidine, 1,4,5,6-tetrahydropyrimidine, 1,2,3,6-tetrahydropyrazine, 1,2,3,4-tetrahydropyrazine, 5,6-dihydro-4H-[1,2]oxazine, 5,6-dihydro-2H-[1,2]oxazine, 3,6-dihydro-2H-[1,2]oxazine, 3,4-dihydro-2H-[1,2]oxazine, 5,6-dihydro-4H-[1,2]thiazine, 5,6-dihydro-2H-[1,2]thiazine, 3,6-dihydro-2H-[1,2]thiazine, 3,4-dihydro-2H-[1,2]thiazine, 5,6-dihydro-2H-[1,3]oxazine, 5,6-dihydro-4H-[1,3]oxazine, 3,6-dihydro-2H-[1,3]oxazine, 3,4-dihydro-2H-[1,3]oxazine, 3,6-dihydro-2H-[1,4]oxazine, 3,4-dihydro-2H-[1,4]oxazine, 5,6-dihydro-2H-[1,3]thiazine, 5,6-dihydro-4H-[1,3]thiazine, 3,6-dihydro-2H-[1,3]thiazine, 3,4-dihydro-2H-[1,3]thiazine, 3,6-dihydro-2H-[1,4]thiazine, 3,4-dihydro-2H-[1,4]thiazine, 1,2,3,6-tetrahydro-[1,2,4]triazine, 1,2,3,4-tetrahydro-[1,2,4]triazine, 1,2,3,4-tetrahydro-[1,3,5]triazine, 2,3,4,5-tetrahydro-[1,2,4]triazine, 1,4,5,6-tetrahydro-[1,2,4]triazine, 5,6-dihydro-[1,4,2]dioxazine, 5,6-dihydro-[1,4,2]dioxazine, 5,6-dihydro-[1,4,2]dithiazine, 2,3-dihydro-[1,4,2]dioxazine, 3,4-dihydro-2H-[1,3,4]oxadiazine, 3,6-dihydro-2H-[1,3,4]oxadiazine, 3,4-dihydro-2H-[1,3,5]oxadiazine, 3,6-dihydro-2H-[1,3,5]oxadiazine, 5,6-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-4H-[1,2,5]oxadiazine, 3,4-dihydro-2H-[1,3,4]thiadiazine, 3,6-dihydro-2H-[1,3,4]thiadiazine, 3,4-dihydro-2H-[1,3,5]thiadiazine, 3,6-dihydro-2H-[1,3,5]thiadiazine, 5,6-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-4H-[1,2,5]thiadiazine, 5,6-dihydro-2H-[1,2,3]oxadiazine, 3,6-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-4H-[1,3,4]oxadiazine, 3,4-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-2H-[1,2,3]thiadiazine, 3,6-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-4H-[1,3,4]thiadiazine, 3,4-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-[1,4,3]oxathiazine, 5,6-dihydro-[1,4,2]oxathiazine, 2,3-dihydro-[1,4,3]oxathiazine, 2,3-dihydro-[1,4,2]oxathiazine, 4,5-dihydropyridine, 1,6-dihydropyridine, 5,6-dihydropyridine, 2H-pyran, 2H-thiin, 3,6-dihydropyridine, 2,3-dihydropyridazine, 2,5-dihydropyridazine, 4,5-dihydropyridazine, 1,2-dihydropyridazine, 2,3-dihydropyrimidine, 2,5-dihydropyrimidine, 5,6-dihydropyrimidine, 3,6-dihydropyrimidine, 4,5-dihydropyrazine, 5,6-dihydropyrazine, 3,6-dihydropyrazine, 4,5-dihydropyrazine, 1,4-dihydropyrazine, 1,4-dithiin, 1,4-dioxin, 2H-1,2-oxazine, 6H-1,2-oxazine, 4H-1,2-oxazine, 2H-1,3-oxazine, 4H-1,3-oxazine, 6H-1,3-oxazine, 2H-1,4-oxazine, 4H-1,4-oxazine, 2H-1,3-thiazine, 2H-1,4-thiazine, 4H-1,2-thiazine, 6H-1,3-thiazine, 4H-1,4-thiazine, 2H-1,2-thiazine, 6H-1,2-thiazine, 1,4-oxathiin, 2H,5H-1,2,3-triazine, 1H,4H-1,2,3-triazine, 4,5-dihydro-1,2,3-triazine, 1H,6H-1,2,3-triazine, 1,2-dihydro-1,2,3-triazine, 2,3-dihydro-1,2,4-triazine, 3H,6H-1,2,4-triazine, 1H,6H-1,2,4-triazine, 3,4-dihydro-1,2,4-triazine, 1H,4H-1,2,4-triazine, 5,6-dihydro-1,2,4-triazine, 4,5-dihydro-1,2,4-triazine, 2H,5H-1,2,4-triazine, 1,2-dihydro-1,2,4-triazine, 1H,4H-1,3,5-triazine, 1,2-dihydro-1,3,5-triazine, 1,4,2-dithiazine, 1,4,2-dioxazine, 2H-1,3,4-oxadiazine, 2H-1,3,5-oxadiazine, 6H-1,2,5-oxadiazine, 4H-1,3,4-oxadiazine, 4H-1,3,5-oxadiazine, 4H-1,2,5-oxadiazine, 2H-1,3,5-thiadiazine, 6H-1,2,5-thiadiazine, 4H-1,3,4-thiadiazine, 4H-1,3,5-thiadiazine, 4H-1,2,5-thiadiazine, 2H-1,3,4-thiadiazine, 6H-1,3,4-thiadiazine, 6H-1,3,4-oxadiazine and 1,4,2-oxathiazine, wherein the heterocycle is optionally vicinally fused with a saturated or unsaturated 5-, 6- or 7-membered ring containing 0, 1 or 2 atoms independently selected from N, O and S;
  • Rf is phenyl substituted by 0, 1 or 2 groups selected from halo, C1-4alkyl, C1-3haloalkyl, —ORd and —NRdRd; or Rf is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4alkyl, C1-3haloalkyl, —ORd and —NRdRd;
  • Rg is hydrogen or —CH3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)OR , —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is S.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00029
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-5alkyl, halo or C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is Re substituted by 1, 2 or 3 substituents independently selected from R5;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R15 is —(CH2)nphenyl substituted by 0, 1, 2 or 3 substituents independently selected from R10.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R15 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R10.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R15 is C1-8alkyl substituted by 0, 1 or 2 substituents selected from R10.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R15 is selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(50 O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(R )C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), -13 N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd; or R10 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRdRd, —C(═NRd)NRdRd, —ORd, —OC(═O)(C1-8alkyl), —OC(═O)NRdRd, —OC(═O)N(Rd)S(═O)2(C1-8alkyl), —OC2-6alkylNRdRd, —OC2-6alkylORd, —SRd, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRdRd, —S(═O)2N(Rd)C(═O)(C1-8alkyl), —S(═O)2N(Rd)C(═O)O(C1-8alkyl), —S(═O)2N(Rd)C(═O)NRdRd, —NRdRd, —N(Rd)C(═O)(C1-8alkyl), —N(Rd)C(═O)O(C1-8alkyl), —N(Rd)C(═O)NRdRd, —N(Rd)C(═NRd)NRdRd, —N(Rd)S(═O)2(C1-8alkyl), —N(Rd)S(═O)2NRdRd, —NRdC2-6alkylNRdRd and —NRdC2-6alkylORd.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R16 is, independently, in each instance, halo, —NH2, —NHC1-3alkyl, —N(C1-3alkyl)C1-3alkyl or C1-3alkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is an unsaturated 6-membered ring containing 0 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORm, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)OR, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylOR2; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups; but in no instance is R4 3,5-ditrifluoromethylphenyl or 3-trifluoromethyl-4-fluorophenyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 6-membered ring containing 0 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(R m)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2 6alkylNRmR2, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups; but in no instance is R4 3,5-ditrifluoromethylphenyl or 3-trifluoromethyl-4-fluorophenyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —Nm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups; but in no instance is R4 3,5-ditrifluoromethylphenyl or 3-trifluoromethyl-4-fluorophenyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is independently, at each instance, C1-8alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRdRd, —OC2-6alkylORd, —NRdRd, —NRdC1-4haloalkyl, —NRdC2-6alkylNRdRd or —NRdC2-6alkylORd, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRdRd, —NRdC(═O)(C1-6alkyl), —NRdC(═O)NRdRd, —NRdCO2(C1-6alkyl), —C1-8alkylORd, —C1-6alkylNRdRd, —S(═O)n(C1-6alkyl), —S(═O)2NRdRd, —NRdS(═O)2(C1-6alkyl) or —OC(═O)NRdRd.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is a —(CRqRq)ophenyl wherein the phenyl is substituted with 0, 1, 2, or 3 substituents independently selected from R10.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is —(CRqRq)oHet wherein Het is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R9 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl.
  • Another aspect of the invention relates to a compound having the structure:
    Figure US20060030618A1-20060209-C00030
    or any pharmaceutically-acceptable salt thereof, wherein:
  • Y is O or S;
  • n is independently, at each instance, 0, 1 or 2.
  • R1 is
    Figure US20060030618A1-20060209-C00031
    or R1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R5; or R1 is Ri substituted by 1, 2 or 3 substituents independently selected from R5;
  • R15 is, independently, in each instance, R10, C1-8alkyl substituted by 0, 1 or 2 substituents selected from R10, —(CH2)nphenyl substituted by 0, 1, 2 or 3 substituents independently selected from R10, or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, the heterocycle and bridge being substituted by 0, 1, 2 or 3 substituents independently selected from R10;
  • R16 is, independently, in each instance, H, halo, —NH2, —NHC1-3alkyl, —N(C1-3alkyl)C1-3alkyl, —OC1-3alkyl, —C1-2haloalkyl, —OC1-2haloalkyl or C1-3alkyl;
  • R4 is
    Figure US20060030618A1-20060209-C00032
    wherein when R1 is bromophenyl, methylphenyl or trifluoromethylphenyl, R4 is not trifluoromethylphenyl or trifluoromethylhalophenyl; or R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, wherein each of the carbon atoms of the heterocycle is substituted by H, C1-9alkyl, C1-4haloalkyl, halo, cyano, oxo, —ORh, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —OC1-6alkylC(═O)ORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRhC1-6alkyl or —NRhC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and each of the available nitrogen atoms in the heterocycle are substituted by H, —C1-6alkylORh, —C1-6alkyl, —C1-6alkylNRhRh, —C1-3alkylC(═O)ORh, —C1-3alkylC(═O)NRhRh, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRhC(═O)C1-6alkyl, —C(═O)Rj or —C1-3alkylRj; or R4 is an 8-, 9-, 10- or 11-membered bicyclic ring, containing 0, 1, 2, 3 or 4 N atoms and 0, 1 or 2 atoms selected from S and O with the remainder being carbon atoms, wherein each of the carbon atoms of the ring is substituted by H, C1-9alkyl, C1-4haloalkyl, halo, cyano, oxo, —ORh, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —OC1-6alkylC(═O)ORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRhC1-6alkyl or —NRhC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any available nitrogen atoms in the ring are substituted by H, —C1-6alkylORh, —C1-6alkyl, —C1-6alkylNRhRh, —C1-3alkylC(═O)ORh, —C1-3alkylC(═O)NRhRh, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRhC(═O)C1-6alkyl, —C(═O)Rj or —C1-3alkylRj;
  • R5 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, nitro, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, naphthyl, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRhRh, —NRhC(═O)Rh, —NRhC(═O)NRhRh, —NRhCO2(C1-6alkyl), —C1-8alkylORh, —C1-6alkylNRhRh, —S(═O)n(C1-6alkyl), —S(═O)2NRhRh, —NRhS(═O)2(C1-6alkyl), —OC(═O)NRhRh, a phenyl ring substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R6 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh or —NRhC2-6alkylORh, —C1-8alkylORh, —C1-6alkylNRhRh, —S(C1-6alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R10; or R6 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R7 is independently, at each instance, H, C1-8alkyl, C1-4haloalkyl, bromo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C1-8alkylORh, —C1-6alkylNRhRh or —S(C1-6alkyl); or R7 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl;
  • R8 is independently, at each instance, H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C1-8alkylORh, —C1-6alkylNRhRh, —S(C1-6alkyl), a phenyl ring substituted with 1, 2, or 3 substituents independently selected from R10, or R8 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10;
  • R9 is independently, at each instance, H, C1-8alkyl, C1-4haloalkyl, halo, nitro, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, —NRhRh or —NRhC2-6alkylORh, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRhRh, —NRhC(═O)(C1-6alkyl), —NRhC(═O)NRhRh, —NRhCO2(C1-6alkyl), —C1-8alkylORh, —C1-6alkylNRhRh, —S(═O)n(C1-6alkyl), —S(═O)2NRhRh, —NRhS(═O)2(C1-6alkyl), —OC(═O)NRhRh, a phenyl ring substituted with 0, 1, 2, or 3 substituents independently selected from R10; or R9 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S substituted with 0, 1, 2, or 3 substituents independently selected from R10; wherein at least one of R5, R6, R7, R8 and R9 is C1-8alkyl, C1-4haloalkyl, halo, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C1-8alkylORh, —C1-6alkylNRhRh or —S(C1-6alkyl); or R9 is a saturated or unsaturated 4- or 5-membered ring heterocycle containing a single nitrogen atom, wherein the ring is substituted with 0, 1 or 2 substituents independently selected from halo, C1-2haloalkyl and C1-3alkyl;
  • R10 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R10 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1 or 2 atoms selected from N, O and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R10 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh;
  • R11 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R11 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R11 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh;
  • R12 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R12 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6,alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRhand —NRhC2-6alkylORh; or R12 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh;
  • R13 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R13 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1, 2 or 3 atoms selected from N, O and S, wherein the ring is fused with 0 or 1 benzo groups and 0 or 1 saturated or unsaturated 5-, 6- or 7-membered heterocyclic ring containing 1, 2 or 3 atoms selected from N, O and S; wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —OC(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R13 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh;
  • R14 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R14 is a saturated or unsaturated 5-, 6- or 7-membered monocyclic or 6-, 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 1 or 2 atoms selected from N, O and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 groups selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R14 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh;
  • Rh is independently, at each instance, H, phenyl, benzyl or C1-6alkyl, the phenyl, benzyl and C1-6alkyl being substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4alkyl, C1-3haloalkyl, —OC1-4alkyl, —NH2, —NHC1-4alkyl, —N(C1-4alkyl)C1-4alkyl;
  • Ri is a heterocycle selected from the group of thiophene, pyrrole, 1,3-oxazole, 1,3-thiazol-5-yl, 1,3,4-oxadiazole, 1,3,4-thiadiazole, 1,2,3-oxadiazole, 1,2,3-thiadiazole, 1H-1,2,3-triazole, isothiazole, 1,2,4-oxadiazole, 1,2,4-thiadiazole 1,2,3,4-oxatriazole, 1,2,3,4-thiatriazole, 1H-1,2,3,4-tetraazole, 1,2,3,5-oxatriazole, 1,2,3,5-thiatriazole, furan, imidazol-1-yl, imidazol-3-yl, imidazol-4-yl, 1,2,4-triazole, 1,2,4-triazole, isoxazole, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, thiolane, pyrrolidine, tetrahydrofuran, 4,5-dihydrothiophene, 2-pyrroline, 4,5-dihydrofuran, pyridazine, pyrimidine, pyrazine, 1,2,3-triazine, 1,2,4-triazine, 1,2,4-triazine, 1,3,5-triazine, pyridine, 2H-3,4,5,6-tetrahydropyran, thiane, 1,2-diazaperhydroine, 1,3-diazaperhydroine, piperazine, 1,3-oxazaperhydroine, morpholine, 1,3-thiazaperhydroine, 1,4-thiazaperhydroine, piperidine, 2H-3,4-dihydropyran, 2,3-dihydro-4H-thiin, 1,4,5,6-tetrahydropyridine, 2H-5,6-dihydropyran, 2,3-dihydro-6H-thiin, 1,2,5,6-tetrahydropyridine, 3,4,5,6-tetrahydropyridine, 4H-pyran, 4H-thiin, 1,4-dihydropyridine, 1,4-dithiane, 1,4-dioxane, 1,4-oxathiane, 1,2-oxazolidine, 1,2-thiazolidine, pyrazolidine, 1,3-oxazolidine, 1,3-thiazolidine, imidazolidine, 1,2,4-oxadiazolidine, 1,3,4-oxadiazolidine, 1,2,4-thiadiazolidine, 1,3,4-thiadiazolidine, 1,2,4-triazolidine, 2-imidazolin-1-yl, 2-imidazolin-2-yl, 2-imidazolin-5-yl, 3-imidazoline, 2-pyrazoline, 4-imidazoline, 2,3-dihydroisothiazole, 4,5-dihydroisoxazole, 4,5-dihydroisothiazole, 2,5-dihydroisoxazole, 2,5-dihydroisothiazole, 2,3-dihydroisoxazole, 4,5-dihydrooxazole, 2,3-dihydrooxazole, 2,5-dihydrooxazole, 4,5-dihydrothiazole, 2,3-dihydrothiazole, 2,5-dihydrothiazole, 1,3,4-oxathiazolidine, 1,4,2-oxathiazolidine, 2,3-dihydro-1H-[1,2,3]triazole, 2,5-dihydro-1H-[1,2,3]triazole, 4,5-dihydro-1H-[1,2,3]triazol-1-yl, 4,5-dihydro-1H-[1,2,3]triazol-3-yl, 4,5-dihydro-1H-[1,2,3]triazol-5-yl, 2,3-dihydro-1H-[1,2,4]triazole, 4,5-dihydro-1H-[1,2,4]triazole, 2,3-dihydro-[1,2,4]oxadiazole, 2,5-dihydro-[1,2,4]oxadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,2,4]thidiazole, 2,5-dihydro-[1,2,4]thiadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,5-dihydro-[1,2,4]oxadiazole, 2,3-dihydro-[1,2,4]oxadiazole, 4,5-dihydro-[1,2,4]oxadiazole, 2,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,2,4]thiadiazole, 4,5-dihydro-[1,2,4]thiadiazole, 2,3-dihydro-[1,3,4]oxadiazole, 2,3-dihydro-[1,3,4]thiadiazole, [1,4,2]oxathiazole, [1,3,4]oxathiazole, 1,3,5-triazaperhydroine, 1,2,4-triazaperhydroine, 1,4,2-dithiazaperhydroine, 1,4,2-dioxazaperhydroine, 1,3,5-oxadiazaperhydroine, 1,2,5-oxadiazaperhydroine, 1,3,4-thiadiazaperhydroine, 1,3,5-thiadiazaperhydroine, 1,2,5-thiadiazaperhydroine, 1,3,4-oxadiazaperhydroine, 1,4,3-oxathiazaperhydroine, 1,4,2-oxathiazaperhydroine, 1,4,5,6-tetrahydropyridazine, 1,2,3,4-tetrahydropyridazine, 1,2,3,6-tetrahydropyridazine, 1,2,5,6-tetrahydropyrimidine, 1,2,3,4-tetrahydropyrimidine, 1,4,5,6-tetrahydropyrimidine, 1,2,3,6-tetrahydropyrazine, 1,2,3,4-tetrahydropyrazine, 5,6-dihydro-4H-[1,2]oxazine, 5,6-dihydro-2H-[1,2]oxazine, 3,6-dihydro-2H-[1,2]oxazine, 3,4-dihydro-2H-[1,2]oxazine, 5,6-dihydro-4H-[1,2]thiazine, 5,6-dihydro-2H-[1,2]thiazine, 3,6-dihydro-2H-[1,2]thiazine, 3,4-dihydro-2H-[1,2]thiazine, 5,6-dihydro-2H-[1,3]oxazine, 5,6-dihydro-4H-[1,3]oxazine, 3,6-dihydro-2H-[1,3]oxazine, 3,4-dihydro-2H-[1,3]oxazine, 3,6-dihydro-2H-[1,4]oxazine, 3,4-dihydro-2H-[1,4]oxazine, 5,6-dihydro-2H-[1,3]thiazine, 5,6-dihydro-4H-[1,3]thiazine, 3,6-dihydro-2H-[1,3]thiazine, 3,4-dihydro-2H-[1,3]thiazine, 3,6-dihydro-2H-[1,4]thiazine, 3,4-dihydro-2H-[1,4]thiazine, 1,2,3,6-tetrahydro-[1,2,4]triazine, 1,2,3,4-tetrahydro-[1,2,4]triazine, 1,2,3,4-tetrahydro-[1,3,5]triazine, 2,3,4,5-tetrahydro-[1,2,4]triazine, 1,4,5,6-tetrahydro-[1,2,4]triazine, 5,6-dihydro-[1,4,2]dioxazine, 5,6-dihydro-[1,4,2]dioxazine, 5,6-dihydro-[1,4,2]dithiazine, 2,3-dihydro-[1,4,2]dioxazine, 3,4-dihydro-2H-[1,3,4]oxadiazine, 3,6-dihydro-2H-[1,3,4]oxadiazine, 3,4-dihydro-2H-[1,3,5]oxadiazine, 3,6-dihydro-2H-[1,3,5]oxadiazine, 5,6-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-4H-[1,2,5]oxadiazine, 3,4-dihydro-2H-[1,3,4]thiadiazine, 3,6-dihydro-2H-[1,3,4]thiadiazine, 3,4-dihydro-2H-[1,3,5]thiadiazine, 3,6-dihydro-2H-[1,3,5]thiadiazine, 5,6-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-4H-[1,2,5]thiadiazine, 5,6-dihydro-2H-[1,2,3]oxadiazine, 3,6-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-4H-[1,3,4]oxadiazine, 3,4-dihydro-2H-[1,2,5]oxadiazine, 5,6-dihydro-2H-[1,2,3]thiadiazine, 3,6-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-4H-[1,3,4]thiadiazine, 3,4-dihydro-2H-[1,2,5]thiadiazine, 5,6-dihydro-[1,4,3]oxathiazine, 5,6-dihydro-[1,4,2]oxathiazine, 2,3-dihydro-[1,4,3]oxathiazine, 2,3-dihydro-[1,4,2]oxathiazine, 4,5-dihydropyridine, 1,6-dihydropyridine, 5,6-dihydropyridine, 2H-pyran, 2H-thiin, 3,6-dihydropyridine, 2,3-dihydropyridazine, 2,5-dihydropyridazine, 4,5-dihydropyridazine, 1,2-dihydropyridazine, 1,4-dihydropyrimidin-1-yl, 1,4-dihydropyrimidin-4-yl, 1,4-dihydropyrimidin-5-yl, 1,4-dihydropyrirnidin-6-yl, 2,3-dihydropyrimidine, 2,5-dihydropyrimidine, 5,6-dihydropyrimidine, 3,6-dihydropyrimidine, 4,5-dihydropyrazine, 5,6-dihydropyrazine, 3,6-dihydropyrazine, 4,5-dihydropyrazine, 1,4-dihydropyrazine, 1,4-dithiin, 1,4-dioxin, 2H-1,2-oxazine, 6H-1,2-oxazine, 4H-1,2-oxazine, 2H-1,3-oxazine, 4H-1,3-oxazine, 6H-1,3-oxazine, 2H-1,4-oxazine, 4H-1,4-oxazine, 2H-1,3-thiazine, 2H-1,4-thiazine, 4H-1,2-thiazine, 6H-1,3-thiazine, 4H-1,4-thiazine, 2H-1,2-thiazine, 6H-1,2-thiazine, 1,4-oxathiin, 2H,5H-1,2,3-triazine, 1H,4H-1,2,3-triazine, 4,5-dihydro-1,2,3-triazine, 1H,6H-1,2,3-triazine, 1,2-dihydro-1,2,3-triazine, 2,3-dihydro-1,2,4-triazine, 3H,6H-1,2,4-triazine, 1H,6H-1,2,4-triazine, 3,4-dihydro-1,2,4-triazine, 1H,4H-1,2,4-triazine, 5,6-dihydro-1,2,4-triazine, 4,5-dihydro-1,2,4-triazine, 2H,5H-1,2,4-triazine, 1,2-dihydro-1,2,4-triazine, 1H,4H-1,3,5-triazine, 1,2-dihydro-1,3,5-triazine, 1,4,2-dithiazine, 1,4,2-dioxazine, 2H-1,3,4-oxadiazine, 2H-1,3,5-oxadiazine, 6H-1,2,5-oxadiazine, 4H-1,3,4-oxadiazine, 4H-1,3,5-oxadiazine, 4H-1,2,5-oxadiazine, 2H-1,3,5-thiadiazine, 6H-1,2,5-thiadiazine, 4H-1,3,4-thiadiazine, 4H-1,3,5-thiadiazine, 4H-1,2,5-thiadiazine, 2H-1,3,4-thiadiazine, 6H-1,3,4-thiadiazine, 6H-1,3,4-oxadiazine, and 1,4,2-oxathiazine, wherein the heterocycle is optionally vicinally fused with a saturated or unsaturated 5-, 6- or 7-membered ring containing 0, 1 or 2 atoms independently selected from N, O and S;
  • Rj is phenyl substituted by 0, 1 or 2 groups selected from halo, C1-4alkyl, C1-3haloalkyl, —ORhand —NRhRh; or Rj is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4alkyl, C1-3haloalkyl, —ORh and —NRhRh; and
  • Rk is hydrogen or —CH3.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00033
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C2-6alkyl or C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is a naphthyl substituted by 0, 1, 2 or 3 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is Ri substituted by 1, 2 or 3 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ri is substituted by one substituent selected from halo, C1-4haloalkyl and C1-5alkyl, and additionally by 0, 1 or 2 substituents independently selected from R5.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R15 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R15 is R10, C1-8alkyl substituted by 0, 1 or 2 substituents selected from R10, or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, the heterocycle and bridge being substituted by 0, 1, 2 or 3 substituents independently selected from R10; or R15 is —(CH2)nphenyl substituted by 0, 1, 2 or 3 substituents independently selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, and C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRhand —NRhC2-6alkylORh.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R16 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R16 is halo, —NHC1-3alkyl, —N(C1-3alkyl)C1-3alkyl, —OC1-3alkyl, —C1-2haloalkyl, —OC1-2haloalkyl or C1-3alkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00034
    wherein at least one of R10, R11, R12, R13 and R14 is other than C1-4haloalkyl or halo.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, at least one of R10, R11, R12, R13 and R14 is —ORh or —NRhRh.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, wherein each of the carbon atoms of the heterocycle is substituted by H, C1-9alkyl, C1-4haloalkyl, halo, cyano, oxo, —ORh, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —OC1-6alkylC(═O)ORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NhC2-6alkylORh, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRhC1-6alkyl or —NRhC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any available nitrogen atoms in the heterocycle are substituted by H, —C1-6alkylORh—C1-6alkyl, —C1-6alkylNRhRh, —C1-3alkylC(═O)ORh, —C1-3alkylC(═O)NRhRh, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRhC(═O)C1-6alkyl, —C(═O)Rj or —C1-3alkylRj.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1 or 2 atoms selected from O, N and S, wherein each of the carbon atoms of the heterocycle is substituted by H, C1-9alkyl, C1-4haloalkyl, halo, cyano, oxo, —ORh, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —OC1-6alkylC(═O)ORh, NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRhC1-6alkyl or —NRhC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any available nitrogen atoms in the bridge are substituted by H, —C1-6alkylORh, —C1-6alkyl, —C1-6alkylNRhRh, —C1-3alkylC(═O)ORh, —C1-3alkylC(═O)NRhRh, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRhC(═O)C1-6alkyl, —C(═O)Rj or —C1-3alkylRj.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is an 8-, 9-, 10- or 11-membered bicyclic ring, containing 1, 2, 3 or 4 N atoms and 0, 1 or 2 atoms selected from S and O with the remainder being carbon atoms, wherein each of the carbon atoms of the ring is substituted by H, C1-9alkyl, C1-4haloalkyl, halo, cyano, oxo, —ORh, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —OC1-6alkylC(═O)ORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRhC1-6alkyl or —NRhC(═O)C1-6alkyl; and saturated carbon atoms may be additionally substituted by ═O; and any available nitrogen atoms in the ring are substituted by H, —C1-6alkylORh, —C1-6alkyl, —C1-6alkylNRhRh, —C1-3alkylC(═O)ORh, —C1-3alkylC(═O)NRhRh, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRhC(═O)C1-6alkyl, —C(═O)Rj or —C1-3alkylRj.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is an 8-, 9-, 10- or 11-membered bicyclic ring, containing 0, 1, 2, 3 or 4 N atoms and 0, 1 or 2 atoms selected from S and O with the remainder being carbon atoms, wherein at least one of the carbon atoms of the ring is substituted by C1-9alkyl, C1-4haloalkyl, halo, cyano, oxo, —ORh, —S(═O)nC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —OC1-6alkylC(═O)ORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRhC1-6alkyl or —NRhC(═O)C1-6alkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R5 and R9 are each independently selected from H, C1-4haloalkyl, halo, nitro, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —CO2(C1-6alkyl), —C(═O)(C1-6alkyl), —C(═O)NRhRh, —NRhC(═O)Rh, —NRhC(═O)NRhRh, —NRhCO2(C1-6alkyl), —C1-8alkylORh, —C1-6alkylNRhRh, —S(═O)n(C1-6alkyl), —S(═O)2NRhRh, —NRhS(═O)2(C1-6alkyl) and —OC(═O)NRhRh.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R6 and R8 are each independently selected from H, C1-5alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, C2-6alkylNRhRh or —NRhC2-6alkylORh, —C1-8alkylORh, —C1-6alkylNRhRh and —S(C1-6alkyl).
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is independently, at each instance, C1-8alkyl, C1-4haloalkyl, —OC1-4haloalkyl, —OC2-6alkylNRhRh, —OC2-6alkylORh, —NRhRh, —NRhC1-4haloalkyl, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh, —C1-8alkylORh, —C1-6alkylNRhRh or —S(C1-6alkyl).
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R10 and R14 are each independently selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh and C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R11 and R13 are independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh, —NRhC2-6alkylORh and C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R12 is independently, at each instance, selected from H, C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh; or R12 is C1-4alkyl substituted by 0, 1, 2 or 3 groups selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)(C1-8alkyl), —C(═O)O(C1-8alkyl), —C(═O)NRhRh, —C(═NRh)NRhRh, —ORh, —OC(═O)(C1-8alkyl), —OC(═O)NRhRh, —OC(═O)N(Rh)S(═O)2(C1-8alkyl), —OC2-6alkylNRhRh, —OC2-6alkylORh, —SRh, —S(═O)(C1-8alkyl), —S(═O)2(C1-8alkyl), —S(═O)2NRhRh, —S(═O)2N(Rh)C(═O)(C1-8alkyl), —S(═O)2N(Rh)C(═O)O(C1-8alkyl), —S(═O)2N(Rh)C(═O)NRhRh, —NRhRh, —N(Rh)C(═O)(C1-8alkyl), —N(Rh)C(═O)O(C1-8alkyl), —N(Rh)C(═O)NRhRh, —N(Rh)C(═NRh)NRhRh, —N(Rh)S(═O)2(C1-8alkyl), —N(Rh)S(═O)2NRhRh, —NRhC2-6alkylNRhRh and —NRhC2-6alkylORh.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is S.
  • Another aspect of the invention relates to a compound having the structure:
    Figure US20060030618A1-20060209-C00035
    wherein:
  • X is O, S or NRm;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm;
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq;
  • R3 is H or C1-4alkyl;
  • R5 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc
  • R6 is, independently at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • R8 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; and (A) R1 is
    Figure US20060030618A1-20060209-C00036
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (B) R1 is
    Figure US20060030618A1-20060209-C00037
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkyl and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═o)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (C) R1 is
    Figure US20060030618A1-20060209-C00038
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (D) R1 is
    Figure US20060030618A1-20060209-C00039
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═o)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═,)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)OR n, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC26alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S,(═)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (E) R1 is
    Figure US20060030618A1-20060209-C00040
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, 13 C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6a —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NR m—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, 80, wherein:
  • R1 is
    Figure US20060030618A1-20060209-C00041
  • R 2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —s(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C)═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, ‘NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms elected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═,)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm,—SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-9alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —O—C1-4haloalkyl, —NRmRm or —NRm—C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-5alkyl, C1-4haloalkyl, I, Br or Cl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00042
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═,)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmR, —S(═O) 2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRm—ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; [C1-8alkyl, C1-5haloalkyl, I, Br or Cl]
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 1 1-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═,)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2- 6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)R s, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-9alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —O—C1-4haloalkyl, —NRmRm or —NRm—C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-5alkyl, C1-4haloalkyl, I, Br or Cl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00043
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[ 1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br;
  • R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a heterocycle selected from indole, 3H-indole, benzo[b]furan, benzothiophene, 1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 1,2,3,4-tetrahydroquinoline, isoquinoline, cinnoline, phthalazine, quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NR mC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn,—S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a heterocycle selected from 6-indole, 7-indole, 6-3H-indole, 7-3H-indole, 6-benzo[b]furan, 7-benzo[b]furan, 6-benzothiophene, 7-benzothiophene, 6-1H-indazole, 7-1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 7-1,2,3,4-tetrahydroquinoline, 8-1,2,3,4-tetrahydroquinoline, isoquinolin-7-yl, isoquinolin-8-yl, 7-cinnoline, 8-cinnoline, phthalazine, 7-quinazoline, 8-quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, ——S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)c(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is CR8.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00044
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm; or
  • R2 is
    Figure US20060030618A1-20060209-C00045
  • R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SR m, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)R s, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm , —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)R s, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)R s, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORS and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —C2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm; and the bridge carbon atoms a substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is CR8.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00046
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C2-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is CR8.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is N.
  • Another aspect of the invention relates to a compound having the structure:
    Figure US20060030618A1-20060209-C00047
    wherein:
  • X is O, S or NRm;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm;
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq;
  • R3 is H or C1-4alkyl;
  • R5 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc
  • R6 is, independently at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • R8 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; and (A) R1 is
    Figure US20060030618A1-20060209-C00048
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NR mC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (B) R1 is
    Figure US20060030618A1-20060209-C00049
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NR mRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 1 1-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (C) R1 is
    Figure US20060030618A1-20060209-C00050
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro- 1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8or N; or (D) R1 is
    Figure US20060030618A1-20060209-C00051
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORs, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn—S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn l , —N(R m)S(═O)2NRmRm—NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (E) R1 is
    Figure US20060030618A1-20060209-C00052
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn,—OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00053
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═,)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(50 O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S,(═)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm—NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the bridge carbon atoms are substituted with 0, I or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-9alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —O—C1-4haloalkyl, —NRmRm or —NRm—C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-5alkyl, C1-4haloalkyl, I, Br or Cl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00054
  • R2is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, ‘C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; [C1-8alkyl, C1-5haloalkyl, I, Br or Cl]
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═,)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —C2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-9alkyl, C1-4haloalkyl, halo, —OC1-6alkyl, —O—C1-4haloalkyl, —NRmRm or —NRm—C1-4haloalkyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is C1-5alkyl, C1-4haloalkyl, I, Br or Cl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic ring containing 0, 1, 2 or 3 atoms selected from N, O and S, so long as the combination O and S atoms is not greater than 1, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Ro is a saturated, partially-saturated or unsaturated 6-membered ring containing 0, 1, 2 or 3 N atoms, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is O.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Y is NH.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00055
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br;
  • R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and Z is CR8 or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a heterocycle selected from indole, 3H-indole, benzo[b]furan, benzothiophene, 1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 1,2,3,4-tetrahydroquinoline, isoquinoline, cinnoline, phthalazine, quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a heterocycle selected from 6-indole, 7-indole, 6-3H-indole, 7-3H-indole, 6-benzo[b]furan, 7-benzo[b]furan, 6-benzothiophene, 7-benzothiophene, 6-1H-indazole, 7-1H-indazole, benzimidazole, benzthiazole, 1H-benzotriazole, 7-quinoline, 8-quinoline, 7-1,2,3,4-tetrahydroquinoline, 8-1,2,3,4-tetrahydroquinoline, isoquinolin-7-yl, isoquinolin-8-yl, 7-cinnoline, 8-cinnoline, phthalazine, 7-quinazoline, 8-quinazoline and quinoxaline, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, 'N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)n, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, 13 C(═NRm)NRmR5, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is CR8.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00056
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm; or
  • R2 is
    Figure US20060030618A1-20060209-C00057
  • R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —C2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O'C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═,)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)s(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a phenyl ring that is vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm; and the bridge carbon atoms are substituted with 0, 1 or 2 ═O groups.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R7 is tert-butyl or trifluoromethyl.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R9 is H.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is CR8.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00058
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 2, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═,)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, R4 is a saturated or unsaturated 5- or 6-membered ring containing 1, 2 or 3 atoms selected from O, N and S, so long as the combination O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —C2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm and —NRmC2-6alkylORm;
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is CR8.
  • In another embodiment, in conjunction with the novel compound embodiments above and below, Z is N.
  • Another aspect of the invention relates to a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, comprising the step of administering a compound having the structure:
    Figure US20060030618A1-20060209-C00059
    wherein:
  • R1 is
    Figure US20060030618A1-20060209-C00060
    or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
  • R2 is H, hydroxy, halo, C1-6alkyl substituted by 0, 1 or 2 substituents selected from R10,
    Figure US20060030618A1-20060209-C00061
    or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7; or R1 and R2 together are
    Figure US20060030618A1-20060209-C00062
  • R3 is H or C1-4alkyl; or R1 and R3 together are
    Figure US20060030618A1-20060209-C00063
  • R4 is
    Figure US20060030618A1-20060209-C00064
  • R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl and —NRaC(═O)C1-6alkyl; or R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O;
  • R5 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C 1-6alkylNRaRa or —NRaC1-6alkylORa; or R5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S;
  • R6 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRa—C1-6alkylORa; or R5 and R6 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C1-6alkyl, (═O), —OC1-6alkyl, —NRaC1-6alkyl, —C1-6alkylORa and C1-6alkylNRaRa, and the available N atoms of the bridge are substituted by Ra, —C1-6alkylORa or C1-6alkylNRaRa;
  • R7 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRa—C1-6alkylORa;
  • R8 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa or —NRa—C1-6alkylORa; or R7 and R8 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C1-6alkyl, (═O), —O—C1-6alkyl, —NRaC1-6alkyl, —C1-6alkylORa and C1-6alkylNRaRa, and the available N atoms of the bridge are substituted by Ra, —C1-6alkylORa or C1-6alkylNRaRa;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRa—C1-6alkylORa;
  • R10 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R11 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NR a—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R10 and R11 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc; wherein if R10, R12, R13 and R14 are all H, then R11 is not —O—C1-6alkylNRaRa or —O—C1-6alkylORa;
  • R12 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R11 and R12 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • R13 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R14 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • Ra is independently, at each instance, H, phenyl, benzyl or C1-6alkyl;
  • Rc is phenyl substituted by 0, 1 or 2 groups selected from halo, C1-3haloalkyl, —ORa and —NRaRa; or Rc is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-3haloalkyl, —ORa and —NRaRa;
  • L1 is a bond, —CH2CH2— or —CH═CH—;
  • L2 is NRa, O, S(═O)n, —N═CH—, —CH2NRa—, —CH═N— or —NRaCH2—;
  • X is O, S or NRa; or X and R2 together are ═N—CH═CH—, ═C—O—, ═C—S—, or ═C—NRa—;
  • Y is NH or O; and
  • n is independently, at each instance, 0, 1 or 2; with the proviso that when R1 is 4-chlorophenyl, then R4 is not 3-methoxyphenyl.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00065
    or a naphthyl or saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the naphthyl, heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
  • R2 is H, hydroxy, halo, C1-6alkyl substituted by 0, 1 or 2 substituents selected from R10,
    Figure US20060030618A1-20060209-C00066
    or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7; and
  • R3 is H or C1-4alkyl.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R1 is
    Figure US20060030618A1-20060209-C00067
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R7 is independently, at each instance, C2-9alkyl or C1-4haloalkyl.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R1 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6and R7.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R2 is
    Figure US20060030618A1-20060209-C00068
    or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R2 is
    Figure US20060030618A1-20060209-C00069
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R1 and R2 together are
    Figure US20060030618A1-20060209-C00070
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R1 and R3 together are
    Figure US20060030618A1-20060209-C00071
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, X and R2 together are ═N—CH═CH—, ═C—O—, ═C—S—, or ═C—NRa—.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00072
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl—O—Ra; and
  • Y2 is —NRa— or —O—.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00073
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl—O—Ra; and
  • Y2 is —NRb— or —O—.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00074
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl—O—Ra; and
  • Y2 is —NRb— or —O—.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00075
  • L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═N)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3akylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl—O—Ra; and
  • Y2 is —NRb— or —O—.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00076
  • Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl—O—Ra; and
  • Y2 is —NRa— or —O—.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O.
  • In another embodiment, in conjunction with the method of treatment embodiments above and below, R4 is
    Figure US20060030618A1-20060209-C00077
  • R10 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa, —C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R11 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; C1-6alkylNRaRa;
  • R12 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6akylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
  • R13 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; and
  • R14 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; wherein one of R10 and R12 is not H.
  • In another embodiment, in conjunction with the method of treatment embodiments above, R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4haloalkyl, —ORa and —NRaRa.
  • Another aspect of the invention relates to a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, comprising the step of administering a compound according to compound description embodiments above—each seperately and alternatively.
  • Another aspect of the invention involves a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, comprising the step of administering a compound having the structure:
    Figure US20060030618A1-20060209-C00078
    wherein:
  • X is O, S or NRm;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm;
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq;
  • R3 is H or C1-4alkyl;
  • R5 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc
  • R6 is, independently at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • R8 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; and (A) R1 is
    Figure US20060030618A1-20060209-C00079
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)OR, —C(═O)NRmRs, C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (B) R1 is
    Figure US20060030618A1-20060209-C00080
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O) 2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (C) R1 is
    Figure US20060030618A1-20060209-C00081
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl-C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (D) R1 is
    Figure US20060030618A1-20060209-C00082
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O) 2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (E) R1 is
    Figure US20060030618A1-20060209-C00083
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRn, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRn, —NRmC2-6alkylNRmRn, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R7 is C2-6alkyl, C1-5haloalkyl, I or Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • Another aspect of the invention involves a method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, comprising the step of administering a compound having the structure:
    Figure US20060030618A1-20060209-C00084
    wherein:
  • X is O, S or NRm;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2R , —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm;
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq;
  • R3 is H or C1-4alkyl;
  • R5 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc
  • R6 is, independently at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • R8 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; and (A) R1 is
    Figure US20060030618A1-20060209-C00085
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRn, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRn, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or -NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)OR , —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (B) R1 is
    Figure US20060030618A1-20060209-C00086
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S (═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (C) R1 is
    Figure US20060030618A1-20060209-C00087
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl-C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (D) R1 is
    Figure US20060030618A1-20060209-C00088
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(R)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)OR s, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NR mRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (E) R1 is
    Figure US20060030618A1-20060209-C00089
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R7 is C2-6alkyl, C1-5haloalkyl, I or Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O-C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • Another aspect of the invention involves a pharmaceutical composition comprising a compound according to any of the above embodiments and a pharmaceutically-acceptable diluent or carrier.
  • Another aspect of the invention involves the use of any of the above compound embodiments as a medicament.
  • Another aspect of the invention relates to the use of a compound according the any one of the above embodiments in the manufacture of a medicament for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
  • Another aspect of the invention relates to the manufacture of a medicament for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, wherein the medicament contains a compound having the structure:
    Figure US20060030618A1-20060209-C00090
    wherein:
  • X is O, S or NRm;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm;
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq;
  • R3 is H or C1-4alkyl;
  • R5 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc
  • R6 is, independently at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • R8 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; and (A) R1 is
    Figure US20060030618A1-20060209-C00091
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (B) R1 is
    Figure US20060030618A1-20060209-C00092
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (C) R1 is
    Figure US20060030618A1-20060209-C00093
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl-C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRn, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (D) R1 is
    Figure US20060030618A1-20060209-C00094
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2- 6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (E) R1 is
    Figure US20060030618A1-20060209-C00095
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm. —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R7 is C2-6alkyl, C1-5haloalkyl, I or Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • Another aspect of the invention relates to the manufacture of a medicament for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, wherein the medicament contains a compound having the structure:
    Figure US20060030618A1-20060209-C00096
    wherein:
  • X is O, S or NRm;
  • n is independently, at each instance, 0, 1 or 2;
  • o is independently, at each instance, 0, 1, 2 or 3;
  • Rm is independently at each instance H or Rn;
  • Rn is independently at each instance C1-8alkyl, phenyl or benzyl;
  • Rq is independently in each instance H, C1-4alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm;
  • Rs is Rn substituted by 0, 1, 2 or 3 substituents independently selected from Rq;
  • R3 is H or C1-4alkyl;
  • R5 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc
  • R6 is, independently at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • R8 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm; and (A) R1 is
    Figure US20060030618A1-20060209-C00097
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (B) R1 is
    Figure US20060030618A1-20060209-C00098
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Ro is a saturated, partially-saturated or unsaturated 5-, 6- or 7-membered monocyclic or 7-, 8-, 9-, 10- or 11-membered bicyclic ring containing 0, 1, 2, 3 or 4 atoms selected from N, O and S, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the ring are substituted by 0, 1 or 2 oxo groups, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from Rp;
  • Rp is independently at each instance C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; and
  • Y is O or NH; or (C) R1 is
    Figure US20060030618A1-20060209-C00099
  • R2 is H, —ORm, halo, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated, partially-saturated or unsaturated 8-, 9-, 10 or 11-membered bicyclic heterocycle containing 1, 2, 3, 4 or 5 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 2, but excluding quinolin-6-yl, 4,5,6,7-tetrahydro-benzo[b]thiophen-2-yl, benzothiazol-2-yl, 2,3-dihydro-benzo[1,4]dioxin-6-yl, wherein the heterocycle is substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, oxo, C1-4haloalkyl, halo, nitro, cyano, —ORm, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, —C(═O)C1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRmC1-6alkyl, —NRmC(═O)C1-6alkyl-C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not 2-aminocarbonylmethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, 2-cyanomethyl-2,3-dihydro-benzo[1,4]dioxin-8-yl, quinolin-3-yl, 3H-quinazolin-4-on-3-yl, benzo[1,3]dioxol-5-yl, 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl or 4,4-dimethyl-3,4-dihydro-1H-quinolin-2-on-7-yl;
  • R7 is C1-8alkyl, C1-5haloalkyl, I or Br R9 is H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm, —NRm—C1-6alkylORm, or —(CH2)nRc;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (D) R1 is
    Figure US20060030618A1-20060209-C00100
  • R2 is C1-6alkyl substituted by 1, 2 or 3 substituents selected from C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm or —NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)ophenyl, wherein the phenyl is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and NRmC2-6alkylORm; or
  • R2 is —(C(Rq)2)oRr, wherein Rr is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the ring and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)ORn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm, and the ring and bridge carbon atoms are substituted with 0, 1 or 2 ═O groups;
  • R7 is C2-8alkyl, C1-5haloalkyl, I, Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N; or (E) R1 is
    Figure US20060030618A1-20060209-C00101
  • R2 is H, —ORm, Cl, C1-3haloalkyl or C1-6alkyl;
  • R4 is a saturated or unsaturated 5- or 6-membered ring containing 0, 1, 2 or 3 atoms selected from O, N and S, so long as the combination of O and S atoms is not greater than 1, wherein the ring is substituted by 0, 1, 2 or 3 substituents independently selected from C1-8alkyl, C1-4haloalkyl, halo, cyano, nitro, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORn, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —NRmC2-6alkylORm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and C1-4alkyl substituted by 1 or 2 groups selected from C1-2haloalkyl, halo, cyano, nitro, —C(═O)Rn, —C(═O)NRmRm, —C(═NRm)NRmRm, —ORm, —OC(═O)Rn, —OC(═O)NRmRm, —OC(═O)N(Rm)S(═O)2Rn, —OC2-6alkylNRmRm, —OC2-6alkylORm, —SRm, —S(═O)Rn, —S(═O)2Rn, —S(═O)2NRmRm, —S(═O)2N(Rm)C(═O)Rn, —S(═O)2N(Rm)C(═O)ORn, —S(═O)2N(Rm)C(═O)NRmRm, —NRmRm, —N(Rm)C(═O)Rn, —N(Rm)C(═O)ORn, —N(Rm)C(═O)NRmRm, —N(Rm)C(═NRm)NRmRm, —N(Rm)S(═O)2Rn, —N(Rm)S(═O)2NRmRm, —NRmC2-6alkylNRmRm, —C(═O)Rs, —C(═O)ORs, —C(═O)NRmRs, —C(═NRm)NRmRs, —ORs, —OC(═O)Rs, —OC(═O)NRmRs, —OC(═O)N(Rm)S(═O)2Rs, —OC2-6alkylNRmRs, —OC2-6alkylORs, —SRs, —S(═O)Rs, —S(═O)2Rs, —S(═O)2NRmRs, —S(═O)2N(Rm)C(═O)Rs, —S(═O)2N(Rm)C(═O)ORs, —S(═O)2N(Rm)C(═O)NRmRs, —NRmRs, —N(Rm)C(═O)Rs, —N(Rm)C(═O)ORs, —N(Rm)C(═O)NRmRs, —N(Rm)C(═NRm)NRmRs, —N(Rm)S(═O)2Rs, —N(Rm)S(═O)2NRmRs, —NRmC2-6alkylNRmRs, —NRmC2-6alkylORs and —NRmC2-6alkylORm; wherein R4 is not unsubstituted phenyl;
  • R7 is C2-6alkyl, C1-5haloalkyl, I or Br;
  • R9 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRmRm, —O—C1-6alkylORm, —NRmRm, —NRm—C1-4haloalkyl, —NRm—C1-6alkylNRmRm or —NRm—C1-6alkylORm;
  • Y is NH; and
  • Z is CR8 or N.
  • The compounds of this invention may have in general several asymmetric centers and are typically depicted in the form of racemic mixtures. This invention is intended to encompass racemic mixtures, partially racemic mixtures and separate enantiomers and diasteromers.
  • Unless otherwise specified, the following definitions apply to terms found in the specification and claims:
  • “Cα-βalkyl” means an alkyl group comprising from α to β carbon atoms in a branched, cyclical or linear relationship or any combination of the three. The alkyl groups described in this section may also contain a double or triple bond. Examples of C1-6alkyl include, but are not limited to the following:
    Figure US20060030618A1-20060209-C00102
  • “Halo” means a halogen atoms selected from F, Cl, Br and I.
  • “Cα-βhaloalkyl” means an alkyl group, as described above, wherein any number—at least one—of the hydrogen atoms attached to the alkyl chain are replaced by F, Cl, Br or I.
  • “Heterocycle” means a ring comprising at least one carbon atom and at least one other atom selected from N, O and S. Examples of heterocycles that may be found in the claims include, but are not limited to, the following:
    Figure US20060030618A1-20060209-C00103
    Figure US20060030618A1-20060209-C00104
  • “Pharmaceutically-acceptable salt” means a salt prepared by conventional means, and are well known by those skilled in the art. The “pharmacologically acceptable salts” include basic salts of inorganic and organic acids, including but not limited to hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methanesulphonic acid, ethanesulfonic acid, malic acid, acetic acid, oxalic acid, tartaric acid, citric acid, lactic acid, fumaric acid, succinic acid, maleic acid, salicylic acid, benzoic acid, phenylacetic acid, mandelic acid and the like. When compounds of the invention include an acidic function such as a carboxy group, then suitable pharmaceutically acceptable cation pairs for the carboxy group are well known to those skilled in the art and include alkaline, alkaline earth, ammonium, quaternary ammonium cations and the like. For additional examples of “pharmacologically acceptable salts,” see infra and Berge et al., J. Pharm. Sci. 66:1 (1977).
  • “Leaving group” generally refers to groups readily displaceable by a nucleophile, such as an amine, a thiol or an alcohol nucleophile. Such leaving groups are well known in the art. Examples of such leaving groups include, but are not limited to, N-hydroxysuccinimide, N-hydroxybenzotriazole, halides, triflates, tosylates and the like. Preferred leaving groups are indicated herein where appropriate.
  • “Protecting group” generally refers to groups well known in the art which are used to prevent selected reactive groups, such as carboxy, amino, hydroxy, mercapto and the like, from undergoing undesired reactions, such as nucleophilic, electrophilic, oxidation, reduction and the like. Preferred protecting groups are indicated herein where appropriate. Examples of amino protecting groups include, but are not limited to, aralkyl, substituted aralkyl, cycloalkenylalkyl and substituted cycloalkenyl alkyl, allyl, substituted allyl, acyl, alkoxycarbonyl, aralkoxycarbonyl, silyl and the like. Examples of aralkyl include, but are not limited to, benzyl, ortho-methylbenzyl, trityl and benzhydryl, which can be optionally substituted with halogen, alkyl, alkoxy, hydroxy, nitro, acylamino, acyl and the like, and salts, such as phosphonium and ammonium salts. Examples of aryl groups include phenyl, naphthyl, indanyl, anthracenyl, 9-(9-phenylfluorenyl), phenanthrenyl, durenyl and the like. Examples of cycloalkenylalkyl or substituted cycloalkylenylalkyl radicals, preferably have 6-10 carbon atoms, include, but are not limited to, cyclohexenyl methyl and the like. Suitable acyl, alkoxycarbonyl and aralkoxycarbonyl groups include benzyloxycarbonyl, t-butoxycarbonyl, iso-butoxycarbonyl, benzoyl, substituted benzoyl, butyryl, acetyl, tri-fluoroacetyl, tri-chloro acetyl, phthaloyl and the like. A mixture of protecting groups can be used to protect the same amino group, such as a primary amino group can be protected by both an aralkyl group and an aralkoxycarbonyl group. Amino protecting groups can also form a heterocyclic ring with the nitrogen to which they are attached, for example, 1,2-bis(methylene)benzene, phthalimidyl, succinimidyl, maleimidyl and the like and where these heterocyclic groups can further include adjoining aryl and cycloalkyl rings. In addition, the heterocyclic groups can be mono-, di- or tri-substituted, such as nitrophthalimidyl. Amino groups may also be protected against undesired reactions, such as oxidation, through the formation of an addition salt, such as hydrochloride, toluenesulfonic acid, trifluoroacetic acid and the like. Many of the amino protecting groups are also suitable for protecting carboxy, hydroxy and mercapto groups. For example, aralkyl groups. Alkyl groups are also suitable groups for protecting hydroxy and mercapto groups, such as tert-butyl.
  • Silyl protecting groups are silicon atoms optionally substituted by one or more alkyl, aryl and aralkyl groups. Suitable silyl protecting groups include, but are not limited to, trimethylsilyl, triethylsilyl, tri-isopropylsilyl, tert-butyldimethylsilyl, dimethylphenylsilyl, 1,2-bis(dimethylsilyl)benzene, 1,2-bis(dimethylsilyl)ethane and diphenylmethylsilyl. Silylation of an amino groups provide mono- or di-silylamino groups. Silylation of aminoalcohol compounds can lead to a N,N,O-tri-silyl derivative. Removal of the silyl function from a silyl ether function is readily accomplished by treatment with, for example, a metal hydroxide or ammonium fluoride reagent, either as a discrete reaction step or in situ during a reaction with the alcohol group. Suitable silylating agents are, for example, trimethylsilyl chloride, tert-butyl-dimethylsilyl chloride, phenyldimethylsilyl chloride, diphenylmethyl silyl chloride or their combination products with imidazole or DMF. Methods for silylation of amines and removal of silyl protecting groups are well known to those skilled in the art. Methods of preparation of these amine derivatives from corresponding amino acids, amino acid amides or amino acid esters are also well known to those skilled in the art of organic chemistry including amino acid/amino acid ester or aminoalcohol chemistry.
  • Protecting groups are removed under conditions which will not affect the remaining portion of the molecule. These methods are well known in the art and include acid hydrolysis, hydrogenolysis and the like. A preferred method involves removal of a protecting group, such as removal of a benzyloxycarbonyl group by hydrogenolysis utilizing palladium on carbon in a suitable solvent system such as an alcohol, acetic acid, and the like or mixtures thereof. A t-butoxycarbonyl protecting group can be removed utilizing an inorganic or organic acid, such as HCl or trifluoroacetic acid, in a suitable solvent system, such as dioxane or methylene chloride. The resulting amino salt can readily be neutralized to yield the free amine. Carboxy protecting group, such as methyl, ethyl, benzyl, tert-butyl, 4-methoxyphenylmethyl and the like, can be removed under hydroylsis and hydrogenolysis conditions well known to those skilled in the art.
  • It should be noted that compounds of the invention may contain groups that may exist in tautomeric forms, such as cyclic and acyclic amidine and guanidine groups, heteroatom substituted heteroaryl groups (Y′═O, S, NR), and the like, which are illustrated in the following examples:
    Figure US20060030618A1-20060209-C00105
    and though one form is named, described, displayed and/or claimed herein, all the tautomeric forms are intended to be inherently included in such name, description, display and/or claim.
  • Prodrugs of the compounds of this invention are also contemplated by this invention. A prodrug is an active or inactive compound that is modified chemically through in vivo physiological action, such as hydrolysis, metabolism and the like, into a compound of this invention following administration of the prodrug to a patient. The suitability and techniques involved in making and using prodrugs are well known by those skilled in the art. For a general discussion of prodrugs involving esters see Svensson and Tunek Drug Metabolism Reviews 165 (1988) and Bundgaard Design of Prodrugs, Elsevier (1985). Examples of a masked carboxylate anion include a variety of esters, such as alkyl (for example, methyl, ethyl), cycloalkyl (for example, cyclohexyl), aralkyl (for example, benzyl, p-methoxybenzyl), and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl). Amines have been masked as arylcarbonyloxymethyl substituted derivatives which are cleaved by esterases in vivo releasing the free drug and formaldehyde (Bungaard J. Med. Chem. 2503 (1989)). Also, drugs containing an acidic NH group, such as imidazole, imide, indole and the like, have been masked with N-acyloxymethyl groups (Bundgaard Design of Prodrugs, Elsevier (1985)). Hydroxy groups have been masked as esters and ethers. EP 039,051 (Sloan and Little, Apr. 11, 1981) discloses Mannich-base hydroxamic acid prodrugs, their preparation and use.
  • Experimental
  • General
  • Unless otherwise noted, all materials were obtained from commercial suppliers and used without further purification. All parts are by weight and temperatures are in Degrees centigrade unless otherwise indicated. All compounds showed NMR spectra consistent with their assigned structures. Melting points were determined on a Buchi apparatus and are uncorrected. Mass spectral data was determined by electrospray ionization technique. All examples were purified to >95% purity as determined by high-performance liquid chromatography (HPLC). Unless otherwise stated, reactions were run at room temperature.
  • The following abbreviations are used:
    • aq.—aqueous
    • cond—concentrated
    • DMF—N,N-dimethylformamide
    • Et2O—diethyl ether
    • EtOAc—ethyl acetate
    • EtOH—ethyl alcohol
    • h—hour
    • min—minutes
    • MeOH—methyl alcohol
    • satd—saturated
    • THF—tetrahydrofuran
    EXAMPLE 1
  • Figure US20060030618A1-20060209-C00106
  • (2E)-3-[4-(tert-Butyl)phenyl]-N-phenylprop-2-enamide. To a 10 mL glass vial was added 4-tert-butyl-trans-cinnamic acid (200 mg, 0.98 mmol, EMKA-Chemie) followed by CH2Cl2 (5 mL), 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride (225 mg, 1.17 mmol, Bachem) and aniline (98 uL, 100 mg, 1.08 mmol, Aldrich). The reaction mixture was magnetically stirred at 25° C. for 24 h. EtOAc was added (60 mL) and the mixture washed successively with 1 N NaOH (2×20 mL), 1 N HCl (20 mL), water (20 mL) and satd NaCl (20 mL), dried over MgSO4, filtered and concentrated. Recrystallization from hexane and CH2Cl2 provided the title product as white crystals. MP 141° C. MS (ESI, pos. ion) m/z: 280 (M+1).
    • EXAMPLE 2
  • Figure US20060030618A1-20060209-C00107
    • (2E)-N-(3,4-Dimethoxyphenyl)-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • To a 20 mL round-bottomed flask equipped with reflux condenser and drying tube was added 4-tert-butyl-trans-cinnamic acid (200 mg, 0.98 mmol, EMKA-Chemie) followed by CH2Cl2 (5 mL), oxalyl chloride (90 uL, 130 mg, 1.03 mmol, Aldrich) and DMF (1 uL). The reaction mixture was magnetically stirred and heated at reflux for 30 min. The reaction mixture was concentrated in vacuo and the residue dissolved in acetone (2 mL). The solution was added to a mixture of 3,4-dimethoxyaniline (180 mg, 1.17 mmol, Aldrich), potassium carbonate (200 mg), water (2 mL) and acetone (2 mL), magnetically stirred at 25° C. in a 10 mL glass vial. The reaction mixture was stirred at 25° C. for 16 h then diluted with EtOAc (60 mL) and washed successively with 1 N HCl (20 mL), 1 N NaOH (20 mL), water (20 mL) and satd NaCl (20 mL), dried over MgSO4, filtered and concentrated. Recrystallization from hexane and CH2Cl2 provided the title product as a yellow solid. MP 115-116° C. MS (ESI, pos. ion) m/z: 340 (M+1).
    • EXAMPLE 3
  • Figure US20060030618A1-20060209-C00108
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-hydroxy-3-methoxyphenyl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00109
  • (a). 4-Amino-2-methoxyphenol. To a round-bottomed flask was added 4-nitroguaiacol (500 mg, 3.0 mmol, Aldrich) and anhydrous EtOH (50 mL). The solution was stirred magnetically under N2 and treated with 10% Pd on carbon (200 mg, Aldrich). The suspension was purged with H2 and then stirred at 25° C. under 1 atm H2 for 16 h. The suspension was purged with N2, filtered through Celite and concentrated in vacuo to provide a dark solid. The solid was washed with 1:1 CH2Cl2:hexane and dried in vacuo to provide the title product as pale brown crystals. MS (ESI, pos. ion) m/z: 140 (M+1).
  • (b). (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-hydroxy-3-methoxyphenyl)prop-2-enamide. Analogous to the procedure used to prepare Example 2, 4-amino-2-methoxyphenol, Example 3(a), (164 mg, 1.18 mmol) and 4-t-butyl-trans-cinnamic acid (200 mg, 0.98 mmol, EMKA-Chemie) provided, after recrystallization of the crude product from CH2Cl2 and hexane, the title product as brown crystals. MP 203-204° C. MS (ESI, pos. ion) m/z: 326 (M+1).
    • EXAMPLE 4
  • Figure US20060030618A1-20060209-C00110
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(2-5,6,7,8-tetrahydronaphthyl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00111
  • (a). 2-5,6,7,8-Tetrahydronaphthylamine. To a round-bottomed flask was added 6-amino-1,2,3,4-tetrahydronaphthalene (500 mg, 3.10 mmol, Maybridge), triethylsilane (2.50 mL, 15.5 mmol, Aldrich) and trifluoroacetic acid (5.0 mL, 66 mmol, Aldrich). The reaction mixture was magnetically stirred vigorously, at 25° C., for 2 h. The solvents were removed in vacuo and the residue dissolved in EtOAc (50 mL) and extracted with 1 N HCl (100 mL, then 50 mL). The combined aqueous acidic extract was washed with EtOAc (50 mL) then basified with 5 N NaOH, at 0° C., to pH 10. The mixture was extracted with CH2Cl2 (3×50 mL), the combined organic extract washed with water (50 mL), satd NaCl (50 mL), dried over Na2SO4, filtered and concentrated in vacuo to provide the title product as a brown oil. MS (ESI, pos. ion) m/z: 148 (M+1).
  • (b). (2E)-3-[4-(tert-Butyl)phenyl]-N-(2-5,6,7,8-tetrahydronaphthyl)prop-2-enamide. Analogous to the procedure used to prepare Example 2, 2-5,6,7,8-tetrahydronaphthylamine, Example 4(a), (173 mg, 1.18 mmol) and 4-t-butyl-trans-cinnamic acid (200 mg, 0.98 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (4:1 hexane:EtOAc) followed by recrystallization from CH2Cl2 and hexane, the title product as white crystals. MP 198-199° C. MS (ESI, pos. ion) m/z: 334 (M+1).
    • EXAMPLE 5
  • Figure US20060030618A1-20060209-C00112
    • (2E)-N-(2H,3H,4H-Benzo[3,4-e]1,4-oxazaperhydroin-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00113
  • (a) 2H,3H,4H-Benzo[e]1,4-oxazaperhydroine-6-ylamine. To a round-bottomed flask was added 2-amino-4-nitrophenol (1.0 g, 6.5 mmol, Aldrich), potassium carbonate (1.8 g, 13 mmol), DMF (5 mL) and 1,2-dibromoethane (0.59 mL, 6.9 mmol, Aldrich). The mixture was magnetically stirred and heated in a 125° C. oil bath, under N2, for 2.5 h. After allowing to cool to 25° C., the reaction mixture was diluted with EtOAc (100 mL), washed with 1 N NaOH (3×50 mL), water (50 mL), satd NaCl (50 mL), dried over Na2SO4, filtered and concentrated to provide a dark residue [MS (ESI, pos. ion) m/z: 181 (M+1)]. The crude product was dissolved in EtOH (100 mL), the solution was purged with N2, treated with 10% Pd on carbon (450 mg, Aldrich), purged with H2then magnetically stirred under 1 atm H2 for 2 h. After purging again with N2, the suspension was filtered through Celite and concentrated in vacuo. Purification by silica gel chromatography (95:5 CH2Cl2:2 M NH3 in EtOH) provided the title product as a viscous brown oil. MS (ESI, pos. ion) m/z: 151 (M+1).
  • (b) (2E)-N-(2H,3H,4H-Benzo[3,4-e]1,4-oxazaperhydroin-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 2, 2H,3H,4H-benzo[e]1,4-oxazaperhydroine-6-ylamine, Example 5(a), (176 mg, 1.18 mmol) and 4-t-butyl-trans-cinnamic acid (200 mg, 0.98 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (step gradient, 6:3:1 CH2Cl2:hexane:EtOAc then 9:1 hexane:EtOAc) the title product as a yellow solid. MP 108-114° C. MS (ESI, pos. ion) m/z: 337 (M+1).
    • EXAMPLE 6
  • Figure US20060030618A1-20060209-C00114
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(3-oxo(2H,4H-benzo[3,4-e]1,4-oxazaperhydroin-6-yl))prop-2-enamide
  • Figure US20060030618A1-20060209-C00115
  • (a) 6-Nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one. A mixture of 4-nitro-2-aminophenol (4.6 g, 30 mmol, Aldrich), benzyltrimethylammonium chloride (6.8 g, 30 mmol, Aldrich) and solid NaHCO3 (12.6 g, 150 mmol) in chloroform (100 mL) was magnetically stirred at 0° C. in a round-bottomed flask and treated dropwise with chloroacetyl chloride (2.9 mL, 33 mmol, Aldrich) over a period of 30 min. After the addition was complete, the reaction mixture was stirred at 0° C. for 1 h, then at 50° C. overnight. The solvent was removed in vacuo and the residue treated with water (50 mL), collected by filtration and washed with water. The solid was recrystallized from EtOH to provide 6-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one. MS (ESI, neg. ion) m/z: 193 (M−1).
    Figure US20060030618A1-20060209-C00116
  • (b) 6-Amino-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one. To a suspension of 6-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 6(a), (0.50 g, 2.6 mmol) and CuCl (0.77 g, 7.8 mmol, Aldrich) in anhydrous MeOH (25 mL), magnetically stirred at 25° C. in a round-bottomed flask, was added potassium borohydride (0.98 g, 18 mmol, Aldrich) in portions. The reaction mixture was stirred at 25° C. for 0.5 h, then the solvent was removed in vacuo and the residue suspended in water (30 mL) and extracted with EtOAc (5×20 mL). The combined organic extracts were washed with satd NaCl, dried over Na2SO4, filtered and concentrated in vacuo to provide the title product as a brown solid.
  • MS (ESI, pos. ion) m/z: 165 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(3-oxo(2H,4H-benzo[3,4-e]1,4-oxazaperhydroin-6-yl))prop-2-enamide. Analogous to the procedure used to prepare Example 1, 6-amino-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 6(b), (207 mg, 1.26 mmol) and 4-tert-butyl-trans-cinnamic acid (258 mg, 1.26 mmol EMKA-Chemie) provided, after recrystallization from EtOAc and hexane, the title compound as a pale yellow solid. MP>280° C. MS (ESI, pos. ion) m/z: 351 (M+1).
    • EXAMPLE 7
  • Figure US20060030618A1-20060209-C00117
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-methyl-3-oxo(2H-benzo[3,4-e]1,4-oxazaperhydroin-6-yl))prop-2-enamide
  • Figure US20060030618A1-20060209-C00118
  • (a) 4-Methyl-6-nitro-2H-benzo[e]1,4-oxazaperhydroin-3-one. A mixture of 6-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 6(a), (970 mg, 25 mmol), benzyltrimethylammonium chloride (114 mg, 0.50 mmol, Aldrich) and iodomethane (0.47 mL, 7.5 mmol, Aldrich) in CH2Cl2 (20 mL) was stirred magnetically in a 100 mL round-bottomed flask and treated with CsOH monohydrate (4.2 g, 25 mmol, Aldrich). The reaction mixture was stirred at 25° C. for 1 h, treated with water (5 mL) and extracted with CH2Cl2 (3×50 mL). The combined organic extract was washed with water (5 mL), satd NaCl (5 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (9:1 hexane:EtOAc) to provide the title product.
  • MS (ESI, pos. ion) m/z: 209 (M+1).
    Figure US20060030618A1-20060209-C00119
  • (b) 6-Amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one. To a solution of 4-methyl-6-nitro-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 7(a), (700 mg, 3.4 mmol) and NiCl2.6H2O (400 mg, 1.7 mmol, Aldrich) in MeOH (10 mL), magnetically stirred in a 100 mL round-bottomed flask at 25° C., was added NaBH4 (190 mg, 5.1 mmol, Aldrich) in portions. The reaction mixture was stirred for 30 min then concentrated in vacuo. Purification by silica gel chromatography (CH2Cl2/EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 179 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-methyl-3-oxo(2H-benzo[3,4-e]1,4-oxazaperhydroin-6-yl))prop-2-enamide. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 6-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 7(b), (180 mg, 1.0 mmol) provided, after purification by silica gel chromatography (4:1 CH2Cl2:EtOAc), the title product as a pale yellow solid. MP 201-203° C. MS (ESI, pos. ion) m/z: 365 (M+1).
    • EXAMPLE 8
  • Figure US20060030618A1-20060209-C00120
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-methyl(2H,3H-benzo[3,4-e]1,4-oxazaperhydroin-6-yl))prop-2-enamide
  • To a solution of lithium aluminum hydride (2.0 mL, 2.0 mmol, 1.0 M in THF, Aldrich), magnetically stirred at 0° C. in a round-bottomed flask under N2, was added 6-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 7b, (180 mg, 1.0 mmol). The reaction mixture was allowed to warm to 25° C. and stirred at that temperature for 1 h. The reaction was quenched by the dropwise addition of 20% H2O/THF (1.2 mL), followed by 5 N NaOH (0.2 mL). The mixture was stirred at 25° C. for 30 min, then filtered and washed with EtOAc.
  • The filtrate was dried over Na2SO4, filtered and concentrated in vacuo [MS (ESI, pos. ion) m/z: 165 (M+1)]. Analogous to the procedure used to prepare Example 1, the crude product and 4-tert-butyl-trans-cinnamic acid provided the title compound as a pale yellow solid. MP 186-188° C. MS (ESI, pos. ion) m/z: 351 (M+1).
    • EXAMPLE 9
  • Figure US20060030618A1-20060209-C00121
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(3-oxo(2H,4H-benzo[e]1,4-oxazaperhydroin-7-yl))prop-2-enamide
  • Figure US20060030618A1-20060209-C00122
  • (a) 7-Nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one. Analogous to the procedure used for the preparation of 6-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 6(a), 5-nitro-2-aminophenol (4.6 g, 30 mmol, Aldrich) and chloroacetyl chloride (2.9 mL, 33 mmol, Aldrich) provided, after recrystallization from EtOH, 7-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one.
  • MS (ESI, neg. ion) m/z: 193 (M−1).
    Figure US20060030618A1-20060209-C00123
  • (b) 7-Amino-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one. A mixture of 7-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 9(a), (970 mg, 5.0 mmol) and 10% Pd on carbon (100 mg, Aldrich) in MeOH (20 mL) was magnetically stirred in a round-bottomed flask under 1 atm H2 for 2 h. The mixture was purged with N2 and filtered through a pad of Celite. Concentration in vacuo provided the title product. MS (ESI, pos. ion) m/z: 165 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(3-oxo(2H,4H-benzo[e]1,4-oxazaperhydroin-7-yl))prop-2-enamide. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 7-amino-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 9(b), (164 mg, 1.0 mmol) provided, after purification by silica gel chromatography (4:1 CH2Cl2:EtOAc), the title product as a pale yellow solid. MP 226-227° C. MS (ESI, pos. ion) m/z: 351 (M+1).
    • EXAMPLE 10
  • Figure US20060030618A1-20060209-C00124
    • (2E)-N-(2H,3H,4H-Benzo[e]1,4-oxazaperhydroin-7-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • To a solution of borane-THF complex (2.5 mL, 2.5 mmol, 1.0 M in THF, Aldrich), magnetically stirred at 0° C. under N2 in a round-bottomed flask equipped with a reflux condenser, was added 7-amino-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 9(b), (160 mg, 1.0 mmol). The reaction mixture was stirred at reflux for 2 h, then treated with EtOH (0.5 mL) and reflux continued for an additional 1 h. The mixture was treated with cond HCl (0.5 mL) and reflux continued for an additional 1 h. The solvent was removed in vacuo and the residue treated with 1 N NaOH (5 mL) and extracted with CH2Cl2 (3×20 mL). The combined organic extracts were washed with satd NaCl, dried over Na2SO4, filtered and concentrated in vacuo to provide the crude aniline [MS (ESI, pos. ion) m/z: 151 (M+1)]. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and the crude aniline, after purification by silica gel chromatography (85:15 CH2Cl2:EtOAc), provided the title product as a pale yellow solid. MP 186-188° C. MS (ESI, pos. ion) m/z: 337 (M+1).
    • EXAMPLE 11
  • Figure US20060030618A1-20060209-C00125
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-methyl-3-oxo(2H-benzo[e]1,4-oxazaperhydroin-7-yl))prop-2-enamide
  • Figure US20060030618A1-20060209-C00126
  • (a) 4-Methyl-7-nitro-2H-benzo[e]1,4-oxazaperhydroin-3-one. Analogous to the procedure used to prepare Example 7(a), 7-nitro-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one, Example 9(a), (970 mg, 25 mmol), benzyltrimethyl-ammonium chloride (110 mg, 0.50 mmol, Aldrich), iodomethane (0.47 mL, 7.5 mmol, Aldrich) and CsOH hydrate (4.2 g, 25 mmol, Aldrich), after purification by silica gel chromatography (9:1 hexane:EtOAc), provided the title product. MS (ESI, neg. ion) m/z: 207 (M−1).
    Figure US20060030618A1-20060209-C00127
  • (b) 7-Amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one. Analogous to the procedure used to prepare Example 3(a), 4-methyl-7-nitro-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 11(a), (1.0 g, 5.0 mmol) provided, after recrystallization from EtOH, the title product. MS (ESI, pos. ion) m/z: 179 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-methyl-3-oxo(2H-benzo[e]1,4-oxazaperhydroin-7-yl))prop-2-enamide. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 7-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 11b, (164 mg, 1.0 mmol) provided, after purification by silica gel chromatography (85:15 CH2Cl2:EtOAc), the title product as a pale yellow solid. MP 194-195° C. MS (ESI, pos. ion) m/z: 365 (M+1).
    • EXAMPLE 12
  • Figure US20060030618A1-20060209-C00128
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(4-methyl(2H,3H-benzo[e]1,4-oxazaperhydroin-7-yl))prop-2-enamide
  • Analogous to the procedure used for the preparation of Example 10, 7-amino-4-methyl-2H-benzo[e]1,4-oxazaperhydroin-3-one, Example 11(b), (180 mg, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (85:15 CH2Cl2:EtOAc), the title product as a pale yellow solid. MP 232-233° C. MS (ESI, pos. ion) m/z: 351 (M+1).
    • EXAMPLE 13
  • Figure US20060030618A1-20060209-C00129
    • Ethyl 6-{(2E)-3-[4-(tert-butyl)phenyl]prop-2-enoylamino}-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate
  • Figure US20060030618A1-20060209-C00130
  • (a) Ethyl 6-nitro-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate. A solution of ethyl 2,3-dibromopropionate (4.8 mL, 33 mmol, Aldrich) in acetone (10 mL, Aldrich) was added to a mixture of 2-amino-4-nitrophenol (4.6 g, 30 mmol, Aldrich) in 80 mL of acetone in a 150 mL round-bottomed flask at 25° C. After the addition, the mixture was stirred at 60° C. for 48 h. The solvent was removed in vacuo, and the residue was treated with water (30 mL) and extracted with CH2Cl2 (3×50 mL). The combined organic phases were washed with satd NaCl (10 mL), dried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel chromatography (9:1 CH2Cl2:EtOAc) to give the title product. MS (ESI, pos. ion) m/z: 253 (M+1).
    Figure US20060030618A1-20060209-C00131
  • (b) Ethyl 6-amino-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate. Analogous to the procedure used to prepare Example 3(a), ethyl 6-nitro-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate, Example 13(a), (1.3 g, 5.0 mmol) provided the title product. MS (ESI, pos. ion) m/z: 223 (M+1). (c). Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (1.3 g, 6.4 mmol, EMKA-Chemie) and ethyl 6-amino-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate, Example 13(b), (1.4 g, 6.4 mmol) provided, after purification by silica gel chromatography (85:15 CH2Cl2:EtOAc), the title product as a pale yellow solid. MP 207-208° C. MS (ESI, pos. ion) m/z: 409 (M+1).
    • EXAMPLE 14
  • Figure US20060030618A1-20060209-C00132
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[2-(hydroxymethyl)(2H,3H,4H-benzo[3,4-e]1,4-oxazaperhydroin-6-yl)]prop-2-enamide
  • A solution of ethyl 6-{(2E)-3-[4-(tert-butyl)phenyl]prop-2-enoylamino}-2H,3H,4H-benzo[e]1,4-oxazaperhydroine-2-carboxylate, Example 13, (410 mg, 1.0 mmol) in THF (5 mL, Aldrich), magnetically stirred in a round-bottomed flask under N2 at 0° C., was treated with lithium borohydride (1.5 mL, 3.0 mmol, 2.0 M in THF, Aldrich). The reaction mixture was allowed to warm to 25° C., and stirred at that temperature for 3 h. The reaction was quenched by the addition of satd NH4Cl (5 mL), stirred for 30 min at 25° C. and extracted with EtOAc (2×15 mL). The combined organic extract was washed with satd NaCl, dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (1:1 CH2Cl2:EtOAc) provided the title product as a pale yellow solid. MP 165-167° C. MS (ESI, pos. ion) m/z: 367 (M+1).
    • EXAMPLE 15
  • Figure US20060030618A1-20060209-C00133
    • (2E)-N-[(3S)-3-(Hydroxymethyl)(2H,3H-benzo[e]1,4-dioxan-6-yl)]-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00134
  • (a) 2-[((2R)Oxiran-2-yl)methoxy]-5-nitrobenzaldehyde. A mixture of (R)-glycidyl tosylate (1.1 g, 5 mmol, Aldrich), 2-hydroxy-5-nitrobenzaldehyde (840 mg, 5.0 mmol, Aldrich) and solid K2CO3 (1.4 g, 10 mmol) in DMF (5 mL, Aldrich) was magnetically stirred in a round-bottomed flask at 100° C. under N2 for 30 min. The reaction mixture was allowed to cool to 25° C., water (20 mL) was added, and the mixture was extracted with EtOAc (3×30 mL). The combined extracts were washed with water (2×20 mL), satd NaCl (10 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (4:1 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 224 (M+1).
    Figure US20060030618A1-20060209-C00135
  • (b) ((2S)-7-Nitro-2H,3H-benzo[e]1,4-dioxan-2-yl)methan-1-ol. To a solution 2 0 of 2-[((2R)oxiran-2-yl)methoxy]-5-nitrobenzaldehyde, Example 15(a), (670 mg, 3.0 mmol) in CH2Cl2 (10 mL), magnetically stirred in a round-bottomed flask at 0° C., was added 86% m-chloroperbenzoic acid (350 mg, 2.0 mmol, Aldrich). The reaction mixture was allowed to warm to 25° C. and stirred at that temperature for 18 h. The mixture was then diluted with CH2Cl2 (20 mL), washed with 10% Na2S2O3 (3 mL), NaHCO3 (3×5 mL), satd NaCl (3 mL), dried over Na2SO4, filtered and concentrated in vacuo. The resulting residue was treated with MeOH (20 mL) and 1 N NaOH (6 mL) and stirred at 25° C. for 16 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (3×10 mL). The combined organic extracts were washed with satd NaCl, dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (3:2 hexane:EtOAc) provided the product. MS (ESI, pos. ion) m/z: 212 (M+1).
  • (c) (2E)-N-[(3S)-3-(Hydroxymethyl)(2H,3H-benzo[e]1,4-dioxan-6-yl)]-3-[4-(tert-butyl)phenyl]prop-2-enamide. A mixture of ((2S)-7-nitro-2H,3H-benzo[e]1,4-dioxan-2-yl)methan-1-ol, Example 15(b), (110 mg, 0.5 mmol) and 10% Pd on carbon (20 mg, Aldrich) in MeOH (5 mL), in a round-bottomed flask, was magnetically stirred under 1 atm H2 for 2 h. The mixture was purged with N2, filtered through a pad of Celite and concentrated in vacuo to provide the crude aniline [MS (ESI, pos. ion) m/z: 182 (M+1)]. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (102 mg, 0.5 mmol, EMKA Chemie) and the crude aniline, provided the title product as a white solid. MP 169-171° C. MS (ESI, pos. ion) m/z: 368 (M+1).
    • EXAMPLE 16
  • Figure US20060030618A1-20060209-C00136
    • (2E)-N-[(3R)-3-(Hydroxymethyl)(2H,3H-benzo[e]1,4-dioxan-6-yl)]-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Analogous to the procedure described for Example 15, the title product was prepared starting from (S)-glycidyl tosylate (Aldrich), 2-hydroxy-5-nitrobenzaldehyde (Aldrich) and 4-tert-butyl-trans-cinnamic acid (EMKA Chemie). MP 170-171° C. MS (ESI, pos. ion) m/z: 368 (M+1).
    • EXAMPLE 17
  • Figure US20060030618A1-20060209-C00137
    • (2E)-N-[(2R)-2-(Hydroxymethyl)(2H,3H-benzo[3,4-e]1,4-dioxan-6-yl)]-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00138
  • (a) (2-Methoxy-4-nitrophenyl)methan-1-ol. To a solution of 2-methoxy-4-nitrobenzoic acid (2.0 g, 10 mmol, Aldrich) in THF (30 mL), magnetically stirred at 0° C. under N2 in a round-bottomed flask equipped with a reflux condenser, was added borane-THF complex (30 mL, 30 mmol, 1.0 M in THF, Aldrich). The reaction mixture was stirred at reflux overnight. The reaction was quenched by the careful addition of MeOH (5 mL), followed by 1 N NaOH (30 mL). The mixture was extracted with EtOAc (2×50 mL), the combined organic extracts were washed with satd NaCl, dried over Na2SO4, filtered and concentrated in vacuo to give the product. MS (ESI, neg. ion) m/z: 182 (M−1).
    Figure US20060030618A1-20060209-C00139
  • (b) 2-Methoxy-4-nitrobenzaldehyde. A mixture of (2-methoxy-4-nitrophenyl)methan-1-ol, Example 17(a), (1.6 g, 8.9 mmol) and MnO2 (15 g, 180 mmol, Aldrich) in 1:1 hexane: CH2Cl2 (60 mL) was magnetically stirred at 40° C. for 3 h. The solid was removed by filtration and washed with CH2Cl2. The filtrate was concentrated in vacuo and the residue was recrystallized from EtOAc and hexane to give the title product. MS (ESI, neg. ion) m/z: 180 (M−1).
    Figure US20060030618A1-20060209-C00140
  • (c) 2-Hydroxy-4-nitrobenzaldehyde. To a solution of 2-methoxy-4-nitrobenzaldehyde, Example 17(b), (190 mg, 1.0 mmol) in CH2Cl2 (5 mL), magnetically stirred at −78° C. in a round-bottomed flask, was added BBr3 (0.19 mL, 2.0 mmol, Aldrich). The reaction mixture was allowed to warm to 25° C. and stirred at that temperature for 2 h. The reaction mixture was then cooled to −78° C., and treated with MeOH (5 mL). The mixture was allowed to warm to 25° C. , stirred at that temperature for 30 min, then concentrated in vacuo. Purification by silica gel chromatography (3:2 hexane:EtOAc) provided 2-hydroxy-4-nitrobenzaldehyde. MS (ESI, neg. ion) m/z: 166 (M−1).
  • (d) (2E)-N-[(2R)-2-(Hydroxymethyl)(2H,3H-benzo[3,4-e]1,4-dioxan-6-yl)]-3-[4-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure described for Example 15, the title product was obtained as a white solid from 2-hydroxy-4-nitrobenzaldehyde, Example 17(c), (S)-glycidyl tosylate (Aldrich) and 4-tert-butyl-trans-cinnamic acid (EMKA-Chemie). MP 159-160° C. MS (ESI, pos. ion) m/z: 368 (M+1).
    • EXAMPLE 18
  • Figure US20060030618A1-20060209-C00141
    • (2E)-N-[(2S)-2-(Hydroxymethyl)(2H,3H-benzo[3,4-e]1,4-dioxan-6-yl)]-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Analogous to the procedure described for Example 15, the title product was prepared starting from 2-hydroxy-4-nitrobenzaldehyde, Example 17(c), (R)-glycidyl tosylate (Aldrich) and 4-tert-butyl-trans-cinnamic acid (EMKA Chemie). MP 169-170° C. MS (ESI, pos. ion) m/z: 368 (M+1).
    • EXAMPLE 19
  • Figure US20060030618A1-20060209-C00142
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(7-1,2,3,4-tetrahydroquinolyl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00143
  • (a) 7-Nitro-1,2,3,4-tetrahydroquinoline. To a round-bottomed flask equipped with magnetic stirring was added 1,2,3,4-tetrahydroquinoline (6.3 mL, 50 mmol, Aldrich) and 96% H2SO4 (42 mL). The mixture was stirred until all of the amine had dissolved, then cooled to 0° C. and treated with KNO3 (5.9 g, 59 mmol) in portions. The reaction mixture was allowed to warm to 25° C. and stirred overnight at that temperature. The mixture was then cooled to 0° C. and neutralized with solid NaOH followed by 5 N NaOH until pH 11 was reached. The mixture was extracted with CH2Cl2 and the extract was dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (8:1 hexane:EtOAc) provided 7-nitro-1,2,3,4-tetrahydroquinoline as an orange solid. MS (ESI, pos. ion) m/z 179 (M+1).
    Figure US20060030618A1-20060209-C00144
  • (b) 7-1,2,3,4-Tetrahydroquinolylamine. Analogous to the procedure used to prepare Example 3(a), 7-nitro-1,2,3,4-tetrahydroquinoline, Example 19(a), (0.35 g, 2.0 mmol) provided the aniline as a pale gray oil. MS (ESI, pos. ion) m/z: 149 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(7-1,2,3,4-tetrahydroquinolyl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 7-1,2,3,4-tetrahydroquinolyl, Example 19(b), (280 mg, 1.9 mmol) and 4-tert-butyl-trans-cinnamic acid (0.33 g, 1.6 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (3:1 hexane:EtOAc) then recrystallization from EtOAc and hexane, the title product as a yellow solid. MP 225-227° C. MS (ESI, pos. ion) m/z: 335 (M+1).
    • EXAMPLE 20
  • Figure US20060030618A1-20060209-C00145
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methyl(7-1,2,3,4-tetrahydroquinolyl))-prop-2-enamide
  • Figure US20060030618A1-20060209-C00146
  • (a) 1-methyl-7-nitro-1,2,3,4-tetrahydroquinoline. To a solution of 7-nitro-1,2,3,4-tetrahydro-quinoline, Example 19(a), (0.36 g, 2 mmol) in DMF (10 mL), magnetically stirred under N2 at 0° C. in a 15 mL round-bottomed flask, was added sodium hydride (0.12 g, 3 mmol, 60% dispersion in mineral oil, Aldrich). After stirring for 10 min, the reaction mixture was treated with iodomethane (0.24 mL, 4 mmol, Aldrich) dropwise. The reaction mixture was stirred at 0° C. for 1 h, at 25° C. for an additional 1 h, then partitioned between EtOAc and satd NaCl. The aqueous layer was extracted with EtOAc (40 mL) and the combined organic extract was dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (7:1 hexane:EtOAc) provided the product as an orange oil. MS (ESI, pos. ion) m/z: 193 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methyl(7-1,2,3,4-tetrahydroquinolyl))-prop-2-enamide. Analogous to the procedure described for Example 19, steps (b)-(c), 1-methyl-7-nitro-1,2,3,4-tetrahydroquinoline, Example 20(a), (240 mg, 1.3 mmol) and 4-tert-butyl-trans-cinnamic acid (0.23 g, 1.1 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (4:1 hexane:EtOAc) then recrystallization from EtOAc and hexane, the title product as a yellow solid. MP 200-202° C. MS (ESI, pos. ion) m/z: 349 (M+1).
    • EXAMPLE 21
  • Figure US20060030618A1-20060209-C00147
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(2-oxo(6-1,3,4-trihydroquinolyl))prop-2-enamide
  • Figure US20060030618A1-20060209-C00148
  • (a) 6-Nitro-1,3,4-trihydroquinolin-2-one. To a round-bottomed flask equipped with magnetic stirring was added 3,4-dihydro-2(1H)-quinolinone (1.47 g, 10 mmol, Aldrich) and 96% H2SO4 (8.3 mL). The mixture was stirred until all of the material was dissolved, then cooled to 0° C. and treated with KNO3 (1.2 g, 11.7 mmol) in portions. The reaction mixture was allowed to warm to 25° C. and stirred at that temperature overnight. The mixture was basified to pH 9 with 35% NaOH, resulting in a precipitate. The solid was collected by filtration, washed with water and dried in vacuo at 50° C. to provide the title product as a yellow solid. MS (ESI, pos. ion) m/z: 193 (M+1).
    Figure US20060030618A1-20060209-C00149
  • (b) 6-Amino-1,3,4-trihydroquinolin-2-one. Analogous to the procedure used to prepare Example 3(a), 6-nitro-1,3,4-trihydroquinolin-2-one, Example 21(a), (1.7 g, 8.9 mmol) was converted to the title product as a tan solid. MS (ESI, pos. ion) m/z: 163 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(2-oxo(6-1,3,4-trihydroquinolyl))prop-2-enamide. Analogous to the procedure used to prepare Example 1, 6-amino-1,3,4-trihydroquinolin-2-one, Example 21(b), (0.68 g, 4.2 mmol) and 4-tert-butyl-trans-cinnamic acid (0.86 g, 4.2 mmol, EMKA-Chemie) provided, after recrystallization from MeOH, the title product as a pale yellow solid. MP 275-276° C. MS (ESI, pos. ion) m/z: 349 (M+1).
    • EXAMPLE 22
  • Figure US20060030618A1-20060209-C00150
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(2-oxo(7-1,3,4-trihydroquinolyl))prop-2-enamide
  • Figure US20060030618A1-20060209-C00151
  • (a) Ethyl 3-(2,4-dinitrophenyl)prop-2-enoate. A suspension of sodium hydride (2.0 g, 50 mmol, 60% dispersion in mineral oil, Aldrich) in anhydrous THF (100 mL) was magnetically stirred under N2 at 25° C. and treated dropwise with triethyl phosphonoacetate (10 mL, 11 g, 51 mmol, Aldrich). The reaction mixture was stirred for 1 h at 25° C. then treated with 2,4-dinitrobenzaldehyde (9.0 g, 46 mmol, Aldrich) in portions. After stirring overnight at 25° C., the reaction was quenched by the addition of water (50 mL) and concentrated in vacuo to remove the THF. The remaining aqueous mixture was extracted with EtOAc (2×150 mL). The combined organic extract was washed with water (4×100 mL), satd NaCl (75 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (1:4 hexane:EtOAc) provided the title product as a dark oil.
    Figure US20060030618A1-20060209-C00152
  • (b) 7-Amino-1,3,4-trihydroquinolin-2-one. Ethyl 3-(2,4-dinitrophenyl)prop-2-enoate, Example 22(a), (3.0 g, 11 mmol) was dissolved in glacial acetic acid (240 mL), treated with 10% Pd on carbon (2.4 g, Aldrich) and hydrogenated on a Parr shaker apparatus at 65° C., under 60 psi H2, for 3 h. The reaction mixture was allowed to cool to 25° C., purged with N2, filtered through Celite and the filtercake washed with acetic acid (200 mL) and EtOH (200 mL). The combined filtrate was concentrated in vacuo, then treated with 1 N NaOH (150 mL) and extracted with EtOAc (3×100 mL). The combined organic extract was washed with satd NaCl (50 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (EtOAc) provided the title product as a pale yellow solid. MS (ESI, pos. ion) m/z: 163 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(2-oxo(7-1,3,4-trihydroquinolyl))prop-2-enamide. Analogous to the procedure used to prepare Example 1, 7-amino-1,3,4-trihydroquinolin-2-one, Example 22(b), (300 mg, 1.8 mmol) and 4-tert-butyl-trans-cinnamic acid (370 mg, 1.8 mmol, EMKA-Chemie) provided the title product as white crystals. MP 288-290° C. MS (ESI, pos. ion) m/z: 349 (M+1).
    • EXAMPLE 23
  • Figure US20060030618A1-20060209-C00153
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(3-hydroxyphenyl)prop-2-enamide
  • To a round-bottomed flask equipped with magnetic stirring was added 4-tert-butyl-trans-cinnamic acid (530 mg, 2.43 mmol, EMKA-Chemie), CH2Cl2 (10 mL), and DMF (10 uL, Aldrich) under N2. The solution was treated dropwise with oxalyl chloride (3.0 mL, 6.0 mmol, 2.0 M in CH2Cl2, Aldrich) then stirred at 25° C. for 1 h. The reaction mixture was concentrated in vacuo and treated with 3-aminophenol (265 mg, 2.43 mmol, Aldrich), THF (20 mL) and satd K2CO3 (15 mL). The reaction mixture was stirred at 25° C. overnight, then acidified to pH˜4.5 with 1 N HCl. The mixture was extracted with EtOAc (2×30 mL), the combined organic extract was dried and concentrated in vacuo. Purification by silica gel chromatography (2:1 hexane:EtOAc) provided the title product as an oil. MS (ESI, pos. ion) m/z: 296 (M+1).
    • EXAMPLE 24
  • Figure US20060030618A1-20060209-C00154
    • 2-(3-{(2E)-3-[4-(tert-Butyl)phenyl]prop-2-enoylamino}phenoxy)acetic acid
  • To a round-bottomed flask equipped with magnetic stirring was added (2E)-3-[4-(tert-butyl)phenyl]-N-(3-hydroxyphenyl)prop-2-enamide, Example 23, (120 mg, 0.407 mmol), THF (10 mL), tert-butyl bromoacetate (60 uL, 0.407 mmol, Aldrich) and 5 N NaOH (10 mL). The reaction mixture was stirred at 25° C. overnight. The mixture was extracted with EtOAc (20 mL), the organic extract washed with water (20 mL), dried over Na2SO4, filtered and concentrated in vacuo. The resulting residue was treated with trifluoroacetic acid (10 mL), stirred at 25° C. for 2 h, then concentrated in vacuo. Purification by silica gel chromatography (1:2 hexane:EtOAc) provided the title product as an off-white solid. MP 166-172° C. MS (ESI, pos. ion) m/z: 354 (M+1).
    • EXAMPLE 25
  • Figure US20060030618A1-20060209-C00155
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[3-(2-hydroxyethoxy)phenyl]prop-2-enamide
  • To a round-bottomed flask, equipped with magnetic stirring and reflux condenser, was added (2E)-3-[4-(tert-butyl)phenyl]-N-(3-hydroxyphenyl)prop-2-enamide, Example 23, (200 mg, 0.68 mmol), THF (10 mL), 2-bromoethanol (200 uL, 2.80 mmol, Aldrich) and 5 N NaOH (10 mL). The reaction mixture was stirred at reflux for 5 h. After allowing to cool to 25° C., the mixture was extracted with EtOAc (20 mL). The organic extract was washed with water (20 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (2:1 hexane:EtOAc) provided the title product as a colorless oil. MS (ESI, pos. ion) m/z: 340 (M+1).
    • EXAMPLE 26
  • Figure US20060030618A1-20060209-C00156
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[3-(2-methoxyethoxy)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00157
  • (a) 3-(2-Methoxyethoxy)phenylamine. To a round-bottomed flask equipped with magnetic stirring was added 3-aminophenol (1.2 g, 11 mmol, Aldrich), TBF (15 mL) and sodium hydride (440 mg, 11 mmol, 60% in mineral oil, Aldrich) at 0° C. The reaction mixture was allowed to stir at 0° C. for 30 min, then 2-bromoethyl methyl ether (1.0 mL, 11 mmol, Aldrich) was added dropwise. The reaction mixture was stirred at 25° C. overnight, then cooled to 0° C. and quenched with satd NaCl (10 mL). The mixture was extracted with EtOAc (20 mL) and the organic phase was washed with water (20 mL), dried over Na2SO4, filtered and concentrated in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 168 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-[3-(2-methoxyethoxy)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 2, 3-(2-methoxyethoxy)phenylamine, Example 26(a), (350 mg, 2.45 mmol) and 4-tert-butyl-trans-cinnamic acid (500 mg, 2.45 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (5:1 hexane:EtOAc), the title product as a colorless oil. MS (ESI, pos. ion) m/z: 354 (M+1).
    • EXAMPLE 27
  • Figure US20060030618A1-20060209-C00158
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-{3-[2-(1,3-dioxobenzo[c]azolin-2-yl)ethoxy]phenyl}prop-2-enamide
  • Figure US20060030618A1-20060209-C00159
  • (a) 2-[2-(3-Nitrophenoxy)ethyl]benzo[c]azoline-1,3-dione. To a round-bottomed flask, equipped with magnetic stirring, an addition funnel and a reflux condenser, was added 3-nitrophenol (2.0 g, 14 mmol, Fluka), triphenylphosphine (4.9 g, 19 mmol, Aldrich) and DMF (20 mL). A solution of N-[2-hydroxyethyl]phthalimide (2.7 mg, 14 mmol, Aldrich) and diethyl azodicarboxylate (3.3 g, 19 mmol, Aldrich) in DMF (20 mL) was added dropwise through the addition funnel at 25° C. The reaction mixture was stirred at 60° C. for 12 h. The reaction mixture was concentrated in vacuo, dissolved in EtOAc (55 mL), and washed with satd NaCl (20 mL) and water (20 mL). The organic phase was dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (2:1 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 313 (M+1).
    Figure US20060030618A1-20060209-C00160
  • (b) 2-[2-(3-Aminophenoxy)ethyl]benzo[c]azoline-1,3-dione. In a round-bottomed flask, equipped with magnetic stirring, a solution of 2-[2-(3-nitrophenoxy)ethyl]benzo[c]azoline-1,3-dione, Example 27(a), (1.9 g, 6.1 mmol) in 0.5% acetic acid in EtOAc (10 mL), under N2, was treated with 10% Pd on carbon (500 mg, Aldrich). The suspension was purged with H2 and stirred under 1 atm H2 at 25° C. overnight. The suspension was purged with N2 and filtered through a pad of Celite. The solvent was removed in vacuo to provide the title product.
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-{3-[2-(1,3-dioxobenzo[c]azolin-2-yl)ethoxy]phenyl}prop-2-enamide. Analogous to the procedure used to prepare Example 2, 2-[2-(3-aminophenoxy)ethyl]benzo[c]azoline-1,3-dione, Example 27(b), (1.7 g, 6.1 mmol) and 4-tert-butyl-trans-cinnamic acid (1.2 g, 6.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (3:1 hexane:EtOAc), the title product as an off-white film. MS (ESI, pos. ion) m/z: 469 (M+1).
    • EXAMPLE 28
  • Figure US20060030618A1-20060209-C00161
    • (2E)-N-[3-(2-Aminoethoxy)phenyl]-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • To a round-bottomed flask equipped with magnetic stirring was added Example 27, (2E)-3-[4-(tert-butyl)phenyl]-N-{3-[2-(1,3-dioxobenzo[c]azolin-2-yl)ethoxy]phenyl}prop-2-enamide, (856 mg, 1.83 mmol), EtOH (15 mL) and hydrazine (574 uL, 18.3 mmol, Aldrich). The reaction mixture was stirred at 25° C. for 2 h. The mixture was concentrated in vacuo, the residue dissolved in EtOAc (40 mL), washed with 10% K2CO3 (15 mL), water (15 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (step gradient, EtOAc followed by 1:1 EtOAc:EtOH) provided the title product as an oil. MS (ESI, pos. ion) m/z: 339 (M+1).
    • EXAMPLE 29
  • Figure US20060030618A1-20060209-C00162
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-indolin-6-ylprop-2-enamide
  • Figure US20060030618A1-20060209-C00163
  • (a) tert-Butyl 6-(1-aza-2,2-diphenylvinyl)indolinecarboxylate. To a solution of benzophenone imine (0.91 g, 5.0 mmol, Aldrich) in CH2Cl2 (35 mL), magnetically stirred at 25° C. in a round-bottomed flask, was added a solution of 6-aminoindoline dihydrochloride (1.04 g, 5.0 mmol, Biosynth AG) in CH2Cl2 (40 mL). The reaction mixture was stirred at 25° C. for 12 h, then diluted with CH2Cl2 (30 mL), washed with water (30 mL), satd NaCl (30 mL), dried over MgSO4, filtered and concentrated in vacuo. The crude product [MS (ESI, pos. ion) m/z: 299 (M+1)] was dissolved in 1,4-dioxane and treated with di-tert-butyl dicarbonate (8.0 mL, 8.0 mmol, 1.0 M in THF, Aldrich) and 5 N aq. Na2CO3 (5 mL). The reaction mixture was magnetically stirred at 25° C. until complete, then diluted with water (30 mL), and extracted with EtOAc (3×30 mL). The combined organic extract was washed with satd NaCl (30 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (4:1 hexane EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 399 (M+1).
    Figure US20060030618A1-20060209-C00164
  • (b) tert-Butyl 6-aminoindolinecarboxylate. In a round-bottomed flask, a solution of tert-butyl 6-(1-aza-2,2-diphenylvinyl)indolinecarboxylate, Example 29(a), (0.80 g, 2.0 mmol) in 1,4-dioxane (10 mL) was treated with 1 N aq. HCl (10 mL). The reaction mixture was magnetically stirred overnight at 25° C., then diluted with water (20 mL) and extracted with ethyl ether (30 mL). The aqueous phase was treated with 5 N NaOH (10 mL) and extracted with ethyl ether (3×30 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (3:2 hexane EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 235 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-indolin-6-ylprop-2-enamide. Analogous to the procedure used to prepare Example 1, tert-butyl 6-aminoindoline-carboxylate, Example 29(b), (230 mg, 1.0 mmol) and 4-tert-butyl cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (7:3 hexane EtOAc), a crude product which was dissolved in CH2Cl2 (5 mL) and treated with 4 N HCl in dioxane (5 mL, Aldrich). The reaction mixture was magnetically stirred at 25° C. for 1 h, then washed with 5 N NaOH (15 mL), satd NaCl (15 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (55:45 hexane EtOAc) provided the title product. MP 153-167° C. MS (ESI, pos. ion) m/z: 321 (M+1).
    • EXAMPLE 30
  • Figure US20060030618A1-20060209-C00165
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindolin-6-yl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00166
  • (a) 1-Methylindoline-6-ylamine. To a round-bottomed flask was added 6-nitroindoline (1.64 g, 10.0 mmol, Aldrich), 37% aq. formaldehyde (2.35 g, 30.0 mmol, Aldrich) and THF (40 mL). The reaction mixture was magnetically stirred at 25° C. and treated with sodium cyanoborohydride (1.89 g, 30.0 mmol, Aldrich). The reaction mixture was allowed to stir at 25° C. for 30 min, then washed with satd Na2CO3. The aqueous phase was extracted with ethyl ether, the organic phases combined and concentrated in vacuo to a residue. Analogous to the procedure of Goswami, P.; Chowdhury, P.; Indian J Chem, Sect B, 1997, 36 (2), 185-186, the crude residue was dissolved in tetrahydrofuran (60 mL) and added to Zn dust (0.43 g, 6.6 mmol, Aldrich) and AlCl3.6H2O (9.6 g, 40 mmol, Aldrich) in water (2 mL), magnetically stirred at 25° C. The reaction mixture was stirred at 25° C. for 16 h, then filtered. The filtrate was added to cold water (300 mL) and extracted with CH2Cl2 (3×100 mL). The combined organic extract was concentrated in vacuo to provide the title product as a brown solid. MS (ESI, pos. ion) m/z: 149 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindolin-6-yl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 1-methylindoline-6-ylamine, Example 30(a), (150 mg, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided the title product as an amorphous yellow solid. MS (ESI, pos. ion) m/z: 335 (M+1).
    • EXAMPLE 31
  • Figure US20060030618A1-20060209-C00167
    • (2E)-N-(1-Acetyl-3,3-dimethylindolin-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00168
  • (a) N-(2-Bromo-5-nitrophenyl)acetamide. A solution of 2-bromo-5-nitroaniline (43 g, 0.20 mol, Aldrich) in glacial acetic acid (1.3 L), magnetically stirred at 25° C., was treated with acetic anhydride (20 mL, 0.21 mol). The reaction mixture was allowed to stir at 25° C. overnight, then quenched by pouring into water (6 L). The precipitate was collected by filtration, washed with water, and dried in vacuo to provide the title product as an off white solid. MS (ESI, pos. ion) m/z: 259, 262 (M+1, M+3).
    Figure US20060030618A1-20060209-C00169
  • (b) N-(2-Bromo-5-nitrophenyl)-N-(2-methylprop-2-enyl)acetamide. To a flame-dried round-bottomed flask, equipped with magnetic stirring and an addition funnel, was added N-(2-bromo-5-nitrophenyl)acetamide, Example 31(a), (48 g, 0.19 mol), solid potassium carbonate (103 g, 744 mmol) and anhydrous DMF (830 mL). The resulting solution was stirred at 25° C. and treated dropwise, through the addition funnel, with a solution of 3-bromo-2-methylpropene (38 mL, 380 mmol, Aldrich) in anhydrous DMF (100 mL) over 45 min. The reaction mixture was stirred at 25° C. overnight, then filtered and treated with satd NaHCO3. The organic layer was removed and the aqueous layer was extracted with EtOAc (3×150 mL). The combined organic extracts were washed with water (4×70 mL), satd NaCl (70 mL), dried over MgSO4, filtered and concentrated in vacuo to provide the title product as a golden solid. MS (ESI, pos. ion) m/z: 313, 315 (M+1, M+3).
    Figure US20060030618A1-20060209-C00170
  • (c). 1-Acetyl-3,3-dimethyl-6-nitroindoline. To a flame-dried round-bottomed flask, equipped with magnetic stirring, was added N-(2-bromo-5-nitrophenyl)-N-(2-methylprop-2-enyl)acetamide, Example 31(b), (55 g, 0.18 mol), tetraethylammonium chloride hydrate (30.8 g, 186 mmol, Aldrich), sodium formate (14.4 g, 212 mmol, Aldrich), sodium acetate (36.3 g, 443 mmol) and anhydrous DMF (443 mL). The resulting solution was purged with N2 and treated with palladium (II) acetate (3.97 g, 17.7 mmol, Aldrich). The reaction mixture was stirred in an oil bath at 80° C. for 15 h, then allowed to cool to 25° C. and filtered through a pad of Celite. The Celite was washed with EtOAc and the combined filtrate was washed with satd NaHCO3 (500 mL). The aqueous layer was extracted with EtOAc (3×100 mL) and the combined organic extract was washed with water (4×100 mL), satd NaCl (2×100 mL), dried over MgSO4, filtered and concentrated in vacuo to provide 1-acetyl-3,3-dimethyl-6-nitroindoline as a brown solid. MS (ESI, pos. ion) m/z: 235 (M+1).
  • (d) (2E)-N-(1-Acetyl-3,3-dimethylindolin-6-yl)-3-[4-(tert-butyl)phenyl)prop-2-enamide. To a solution of 1-acetyl-3,3-dimethyl-6-nitroindoline, Example 31(c), (110 mg, 0.47 mmol) in ethyl ether (3 mL), magnetically stirred in a round-bottomed flask at 0° C., was added tin (II) chloride dihydrate (0.67 g, 2.96 mmol, Aldrich) and cond HCl (0.3 mL). The reaction mixture was stirred at 0° C. for 10 min, allowed to warm to 25° C. then stirred at that temperature overnight. The reaction mixture was washed with 10 N NaOH (10 mL), extracted with EtOAc and concentrated in vacuo. Analogous to the procedure used to prepare Example 1, the crude product and 4-tert-butyl-trans-cinnamic acid (92 mg, 0.45 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (2:3 hexane:EtOAc), the title product. MP 121° C. MS (ESI, pos. ion) m/z: 391 (M+1).
    • EXAMPLE 32
  • Figure US20060030618A1-20060209-C00171
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(1,3,3-trimethylindolin-6-yl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00172
  • (a) 3,3-Dimethyl-6-nitroindoline. To a round-bottomed flask, equipped with magnetic stirring and a reflux condenser, was added 1-acetyl-3,3-dimethyl-6-nitroindoline, Example 31(c), (1.73 g, 7.39 mmol) and EtOH (20 mL). The solution was treated with 12 N HCl (20 mL) then stirred and heated at reflux for 2 h. The reaction mixture was cooled to 0° C., providing a precipitate which was collected by filtration and dried in vacuo to afford the title product as an off-white solid. MS (ESI, pos. ion) m/z: 193 (M+1).
    Figure US20060030618A1-20060209-C00173
  • (b) 1,3,3-Trimethylindoline-6-ylamine. A solution of 3,3-dimethyl-6-nitroindoline, Example 32(a), (0.23 g, 1.2 mmol) in anhydrous DMF (15 mL) was magnetically stirred at 25° C. and treated with sodium hydride (0.14 g, 3.6 mmol, 60% dispersion in mineral oil, Aldrich), followed by iodomethane (0.17, 1.3 mmol, Aldrich). The reaction mixture was stirred at 25° C. for 3 h, then quenched with water (40 mL) and extracted with EtOAc (3×30 mL). The combined extract was concentrated in vacuo to provide a residue [MS (ESI, pos. ion) m/z: 207 (M+1)] which was immediately dissolved in ethyl ether (5 mL), magnetically stirred at 0° C., and treated with tin (II) chloride dihydrate (1.7 g, 7.5 mmol, Aldrich) and cond HCl (0.8 mL). The reaction mixture was stirred at 0° C. for 10 min, allowed to warm to 25° C., then stirred at that temperature overnight. The reaction mixture was washed with 10 N NaOH (20 mL) and extracted with EtOAc (3×50 mL). The combined extracts were concentrated in vacuo and purified by silica gel chromatography to provide the title product. MS (ESI, pos. ion) m/z: 177 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(1,3,3-trimethylindolin-6-yl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 1,3,3-trimethylindoline-6-ylamine, Example 32(b), (176 mg, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (3:2 hexane:EtOAc), the title product. MP 90-101° C. MS (ESI, pos. ion) m/z: 363 (M+1).
    • EXAMPLE 33
  • Figure US20060030618A1-20060209-C00174
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindol-6-yl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00175
  • (a) 1-Methylindole-6-ylamine. To a round-bottomed flask was added 6-nitroindole (0.81 g, 5.0 mmol, Aldrich) and anhydrous DMF (40 mL). The solution was stirred magnetically and treated with sodium hydride (0.40 g, 10 mmol, 60% dispersion in mineral oil, Aldrich) followed by iodomethane (0.71 gm 10 mmol, Aldrich). Stirring was continued at 25° C. for 30 min, then the reaction mixture was quenched by the addition of water (75 mL) and extracted with EtOAc. The organic extract was concentrated in vacuo to provide a residue which was dissolved in EtOH (40 mL), treated with 10% Pd on carbon (400 mg, Aldrich), purged with H2 and magnetically stirred under 1 atm H2 for 4 h. The suspension was purged with N2, filtered through a pad of Celite and concentrated in vacuo. Purification by silica gel chromatography (50:50 hexane:EtOAc) provided the aniline. MS (ESI, pos. ion) m/z: 147 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindol-6-yl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 1-methylindole-6-ylamine, Example 33(a), (150 mg, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol), after purification by silica gel chromatography (65:35 hexane:EtOAc), provided the title product as a yellow solid. MP 95° C. MS (ESI, pos. ion) m/z: 333 (M+1).
    • EXAMPLE 34
  • Figure US20060030618A1-20060209-C00176
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindol-5-yl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00177
  • (a) 1-Methylindole-5-ylamine. To a round-bottomed flask was added 5-nitroindole (0.81 g, 5.0 mmol, Aldrich) and anhydrous DMF (40 mL). The solution was stirred magnetically and treated with sodium hydride (0.40 g, 10 mmol, 60% dispersion in mineral oil, Aldrich) followed by iodomethane (0.71 gm 10 mmol, Aldrich). Stirring was continued at 25° C. for 30 min, then the reaction mixture was quenched by the addition of water (75 mL) and extracted with EtOAc. The organic extract was concentrated in vacuo to provide a crude residue. Analogous to the procedure of Goswami, P.; Chowdhury, P.; Indian J Chem, Sect B, 1997, 36 (2), 185-186, the crude residue was dissolved in THF (40 mL) and added to Zn dust (0.22 g, 3.3 mmol, Aldrich) and AlCl3.6H2O (4.78 g, 19.8 mmol, Aldrich) in water (1 mL), magnetically stirred at 25° C. The reaction mixture was stirred at 25° C. for 16 h, then filtered. The filtrate was added to cold water (300 mL) and extracted with CH2Cl2 (3×100 mL). The combined organic extract was concentrated in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 147 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindol-5-yl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 1-methylindole-5-ylamine, Example 34(a), (150 mg, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (65:35 hexane:EtOAc), the title product as a crystalline yellow solid. MP 171° C. MS (ESI, pos. ion) m/z: 333 (M+1).
    • EXAMPLE 35
  • Figure US20060030618A1-20060209-C00178
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindolin-5-yl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00179
  • (a) 1-Methyl-5-nitroindoline. To a round-bottomed flask equipped with magnetic stirring was added 5-nitroindoline (0.82, 5.0 mmol, Aldrich), iodomethane (0.71 g, 5.0 mmol, Aldrich), sodium hydroxide (0.24, 6 mmol) and DMF (20 mL). The reaction mixture was stirred at 25° C. for 3 h, diluted with water (50 mL), extracted with EtOAc (3×40 mL) and the combined extracts were concentrated in vacuo. Purification by silica gel chromatography 97:3 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 179 (M+1).
    Figure US20060030618A1-20060209-C00180
  • (b) 1-Methylindoline-5-ylamine. To a solution of 1-methyl-5-nitroindoline, Example 35(a), (0.55 g, 3.1 mmol) in ethyl ether (20 mL), magnetically stirred in a round-bottomed flask at 0° C., was added tin (II) chloride dihydrate (4.5 g, 20 mmol, Aldrich) and cond HCl (2.5 mL). The reaction mixture was stirred at 0° C. for 10 min, allowed to warm to 25° C. then stirred at that temperature overnight. The reaction mixture was washed with 10N NaOH (30 mL) and the aqueous phase extracted with EtOAc (3×20 mL). The combined organic extracts were concentrated in vacuo. Purification by silica gel chromatography (55:45 hexane:EtOAc) provided the aniline. MS (ESI, pos. ion) m/z: 149 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-(1-methylindolin-5-yl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 1-methylindoline-5-ylamine, Example 35(b), (150, 1.0 mmol) and 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (60:40 hexane:EtOAc), the title product as a crystalline yellow solid. MP 194° C. MS (ESI, pos. ion) m/z: 335 (M+1).
    • EXAMPLE 36
  • Figure US20060030618A1-20060209-C00181
  • (2E)-N-Benzoxazol-5-yl-3-[4-(tert-butyl)phenyl]prop-2-enamide
    Figure US20060030618A1-20060209-C00182
  • (a) 5-Nitrobenzoxazole. Following the procedure of A. R. Katritzky et al. Heterocycles 1995, 41, 345, to a round-bottomed flask was added 2-amino-4-nitrophenol (5.0 g, 32 mmol, Aldrich), trimethyl orthoformate (20 mL, 180 mmol, Aldrich) and p-toluenesulfonic acid monohydrate (300 mg, 1.6 mmol, Aldrich). The reaction mixture was magnetically stirred in a 95° C. oil bath for 1 h, and then allowed to cool to 25° C. The mixture was cooled to 0° C. to provide a precipitate which was collected by filtration, washed with cold toluene, pentane, then dried in vacuo to afford the title product as a dark brown powder.
    Figure US20060030618A1-20060209-C00183
  • (b) Benzoxazole-5-ylamine. Analogous to the procedure used to prepare Example 3(a), 5-nitrobenzoxazole, Example 36(a), (2.4 g, 15 mmol) provided, after purification by silica gel chromatography (step gradient, 7:3 then 4.5:5.5 then 3:7 hexane:EtOAc), the title product. MS (ESI, pos. ion) m/z: 135 (M+1).
  • (c) (2E)-N-Benzoxazol-5-yl-3-[4-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, benzoxazole-5-ylamine, Example 36(b), (530 mg, 4.0 mmol) and 4-tert-butyl-trans-cinnamic acid (820 mg, 4.0 mmol, EMKA-Chemie) provided, after twice being purified by silica gel chromatography (7:3 hexane:EtOAc then 1.25% MeOH in CH2Cl2), the title product as white crystals. MP 177° C. MS (ESI, pos. ion) m/z: 321 (M+1).
    • EXAMPLE 37
  • Figure US20060030618A1-20060209-C00184
    • (2E)-N-Benzoxazol-6-yl-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00185
  • (a) Benzoxazole-6-ylamine. Analogous to the procedure described for the preparation of Example 36, steps (a)-(b), 2-amino-5-nitrophenol (5.0 g, 32 mmol, Aldrich) provided the title product as a pale tan solid. MS (ESI, pos. ion) m/z: 135 (M+1).
  • (b) (2E)-N-Benzoxazol-6-yl-3-[4-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, benzoxazole-6-ylamine, Example 37(a), (1.8 g, 13 mmol) and 4-tert-butyl-trans-cinnamic acid (2.7 g, 13 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (6:4:0.2 CH2Cl2:hexane:MeOH), the title product as a tan solid. MP 147-148° C. MS (ESI, pos. ion) m/z: 321 (M+1).
    • EXAMPLE 38
  • Figure US20060030618A1-20060209-C00186
    • (2E)-N-Benzo[b]furan-5-yl-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00187
  • (a) Methyl 2-(2-formyl-4-nitrophenoxy)acetate. To a round-bottomed flask was added a suspension of 2-hydroxy-5-nitrobenzaldehyde (10 g, 60 mmol, Aldrich) in anhydrous EtOH (180 mL). The suspension was treated with KOH (4.4 g, 66 mmol) and heated under N2 with magnetic stirring in a 65° C. oil bath for 45 min. The reaction mixture was allowed to cool to 25° C. and concentrated in vacuo. Anhydrous DMF (180 mL) was added, and the reaction flask was cooled in an ice bath and charged with methyl bromoacetate (10 mL, 110 mL, Aldrich). The reaction mixture was stirred for 3.5 h at 25° C., then the solvent was removed in vacuo. Water (200 mL) was added, and the mixture was extracted with EtOAc (3×50 mL). The combined organic extract was washed with 1 M H3PO4, satd NaHCO3, and satd NaCl. After drying over MgSO4, the organic layer was filtered and concentrated in vacuo. The residue was recrystallized from CH2Cl2 and hexane to afford the title product as a pale yellow solid. MS (ESI, pos. ion) m/z: 240 (M+1).
    Figure US20060030618A1-20060209-C00188
  • (b) Ethyl 5-nitrobenzo[d]furan-2-carboxylate. To a 250 mL round-bottomed flask was added methyl 2-(2-formyl-4-nitrophenoxy)acetate, Example 38(a), (5.3 g, 22 mmol), EtOH (110 mL) and 1,8-diazabicyclo[5.4.0]undec-7-ene (3.7 g, 24 mmol, Aldrich). The reaction mixture was magnetically stirred at 25° C. for 20 h, then concentrated to approximately half of its volume in vacuo. After cooling the mixture in an ice bath for 20 min, a precipitate formed which was collected by filtration and washed with ice cold EtOH. The resulting pale yellow solid was dried in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 253 (M+H2O).
    Figure US20060030618A1-20060209-C00189
  • (c) 5-Nitrobenzo[b]furan-2-carboxylic acid. To a 250 mL round-bottomed flask was added ethyl 5-nitrobenzo[d]furan-2-carboxylate, Example 38(b), (1.0 g, 4.3 mmol), EtOH (10 mL), and KOH (610 mg, 11 mmol) in 10 mL of H2O. The reaction mixture was stirred at 25° C. for 24 h, then treated with 1 M H3PO4 (200 mL) and saturated with solid NaCl. The aqueous layer was extracted with EtOAc (3×70 mL), and the combined organic extracts were washed with satd NaCl, dried over MgSO4, filtered and concentrated in vacuo to provide the title product as a yellowish-white powder. MS (ESI, pos. ion) m/z: 225 (M+H2O).
    Figure US20060030618A1-20060209-C00190
  • (d). 5-Nitrobenzofuran. To a 100 mL round-bottomed flask was added 5-nitrobenzo[b]furan-2-carboxylic acid, Example 38(c), (860 mg, 4.2 mmol), copper (830 mg, 13 mmol, Aldrich), and quinoline (38 mL, Aldrich). The reaction flask was placed in a 185° C. oil bath and magnetically stirred for 20 min under N2. After allowing to cool to 25° C., the mixture was filtered through a 1″ pad of Celite. To the filtrate was added 10% aq. HCl (300 mL) and the aqueous layer was extracted with Et2O (3×100 mL). The combined ethereal layers were washed with 10% HCl (4×200 mL, 1×100 mL), satd NaHCO3 (200 mL), and satd NaCl (100 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (10:0.25 hexanes:EtOAc) provided 5-nitrobenzofuran as a white solid.
    Figure US20060030618A1-20060209-C00191
  • (e) Benzo[b]furan-5-ylamine. To a 150 mL round-bottomed flask was added 5-nitrobenzofuran, Example 38(d), (270 mg, 1.7 mmol) and ethyl ether (16 mL). The mixture was magnetically stirred at 0° C. under N2 and treated with a solution of tin (II) chloride dihydrate (3.4 g, 15 mmol, Aldrich) in 12 M aq. HCl (2 mL). The reaction mixture was stirred at 0° C. for 10 min, then allowed to warm to 25° C. and stirred at that temperature for 20 h. Water and 2 N NaOH (pH >10) were added followed by Celite (10 g). The mixture was filtered through a pad of Celite and the filtrate extracted with EtOAc. The organic extract was washed with 2 N NaOH, satd NaCl, dried over K2CO3, filtered and concentrated in vacuo to provide the title product as a pale yellow oil. MS (ESI, pos. ion) m/z: 134 (M+1).
  • (f) (2E)-N-Benzo[b]furan-5-yl-3-[4-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, benzo[b]furan-5-ylamine, Example 38(e), (230 mg, 1.7 mmol) and 4-tert-butyl-trans-cinnamic acid (350 mg, 1.7 mmol, EMKA-Chemie) provided, after purification by silica gel chromatography (9:1 hexane:EtOAc), the title product as white crystals. MP 149-150° C. MS (ESI, pos. ion) m/z: 320 (M+1).
    • EXAMPLE 39
  • Figure US20060030618A1-20060209-C00192
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-(2,3-dihydrobenzo[b]furan-5-yl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00193
  • (a) 2,3-Dihydrobenzo[b]furan-5-ylamine. To a 150 mL round-bottomed flask was added 5-nitrobenzofuran, Example 38(d), (250 mg, 1.5 mmol), EtOAc (16 mL) and 10% Pd on carbon (33 mg, Aldrich). The suspension was stirred at 25° C. under 1 atm H2 for 24 h, then purged with N2, filtered through Celite and concentrated in vacuo to provide the aniline as a red-brown solid. MS (ESI, pos. ion) m/z: 136 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-(2,3-dihydrobenzo[b]furan-5-yl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 2,3-dihydrobenzo[b]furan-5-ylamine, Example 39(a), (240 mg, 1.8 mmol) and 4-tert-butyl-trans-cinnamic acid (370 mg, 1.8 mmol, EMKA-Chemie) provided the crude title product. The product was purified by silica gel chromatography (9:1:0.25 hexane:EtOAc:MeOH) to provide 45 mg of the title product and additional impure fractions. The impure fractions were combined and concentrated in vacuo. The residue was dissolved in MeOH (25 mL), treated with 5 N NaOH (10 mL) and stirred for 1 h. The mixture was diluted with 5 N NaOH (100 mL) and extracted with EtOAc. The organic phase was washed with 5 N NaOH (2×), 5% citric acid, satd NaCl, dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (8:1:0.5 hexane:EtOAc: 2 M NH3 in MeOH) provided an additional the title product as a white solid. MP 175-176° C. MS (ESI, pos. ion) m/z: 322 (M+1).
    • EXAMPLE 40
  • Figure US20060030618A1-20060209-C00194
    • N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3,3-bis(4-methylphenyl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00195
  • (a) 3,3-Bis(4-methylphenyl)prop-2-enoic acid. Triethyl phosphonoacetate (2.0 mL, 10 mmol, Aldrich) was added dropwise to a suspension of NaH (0.44 g, 11 mmol, 60% dispersion in mineral oil, Aldrich) in anhydrous THF (16 mL), magnetically stirred at 0° C. under Ar, in a round-bottomed flask equipped with a reflux condenser. The reaction mixture was allowed to warm to 25° C. then stirred at that temperature for 0.5 h. 4,4′-Dimethylbenzophenone (2.1 g, 10 mmol, Aldrich) was added in one portion and the reaction mixture stirred and heated at reflux for 48 h. After allowing to cool to 25° C., the reaction mixture was quenched with H2O (30 mL) and extracted with Et2O (4×10 mL). The combined organic extract was washed with H2O (5 mL), dried over MgSO4, filtered and concentrated in vacuo to an oily residue. The residue was dissolved in 1,4-dioxane (2.5 mL), treated with H2O (7 mL) and KOH (1.1 g, 20 mmol), then stirred and heated at reflux under Ar for 18 h. The reaction mixture was allowed to cool to 25° C., diluted with H2O (50 mL) and washed with Et2O (10 mL). The aqueous phase was acidified with 1 N HCl and extracted with chloroform. The combined chloroform extracts were washed with satd NaCl, dried over MgSO4, filtered and concentrated in vacuo to provide the acid as a white solid. MS (ESI, pos. ion) m/z: 253 (M+1).
  • (b) N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3,3-bis(4-methylphenyl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, 3,3-bis(4-methylphenyl)prop-2-enoic acid, Example 40(a), (0.50 g, 2.0 mmol) and 1,4-benzodioxan-6-amine (0.33 g, 2.2 mmol, Aldrich) provided, after purification by silica gel chromatography (chloroform), the title product as a yellow solid. MP 163-164° C. MS (ESI, pos. ion) m/z: 386 (M+1).
    • EXAMPLE 41
  • Figure US20060030618A1-20060209-C00196
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-2-methylprop-2-enamide
  • Figure US20060030618A1-20060209-C00197
  • (a) (2E)-3-[4-(tert-Butyl)phenyl]-2-methylprop-2-enoic acid. Analogous to the procedure described for the preparation of Example 40, step (a), triethyl 2-phosphonopropionate (2.4 g, 10 mmol, Aldrich) and 4-tert-butylbenzaldehyde (1.6 g, 10 mmol, Aldrich) provided the title product as a yellow solid. MS (ESI, pos. ion) m/z: 219 (M+1).
  • (b) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-2-methylprop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[4-(tert-butyl)phenyl]-2-methylprop-2-enoic acid, Example 41(a), (0.44 g, 2.0 mmol) and 1,4-benzodioxan-6-amine (0.33 g, 2.2 mmol, Aldrich) provided, after purification by silica gel chromatography (chloroform), the title product as an off-white solid. MP 157-158° C. MS (ESI, pos. ion) m/z: 352 (M+1).
    • EXAMPLE 42
  • Figure US20060030618A1-20060209-C00198
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-2-ethylprop-2-enamide
  • Figure US20060030618A1-20060209-C00199
  • (a) (2E)-3-[4-(tert-Butyl)phenyl]-2-ethylprop-2-enoic acid. Analogous to the procedure described for the preparation of Example 40, step (a), triethyl 2-phosphonobutyrate (2.5 g, 10 mmol, Aldrich) and 4-tert-butylbenzaldehyde (1.6 g, 10 mmol, Aldrich) provided the title product as a white solid. MS (ESI, pos. ion) m/z: 233 (M+1).
  • (b) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-2-ethylprop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[4-(tert-butyl)phenyl]-2-ethylprop-2-enoic acid, Example 42(a), (0.46 g, 2.0 mmol) and 1,4-benzodioxan-6-amine (0.33 g, 2.2 mmol, Aldrich) provided, after purification by silica gel chromatography (chloroform), the title product as a white solid. MP 133-134° C. MS (ESI, pos. ion) m/z: 366 (M+1).
    • EXAMPLE 43
  • Figure US20060030618A1-20060209-C00200
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-(4-cyclopropylphenyl)prop-2- enamide
  • Figure US20060030618A1-20060209-C00201
  • (a) Ethyl 4-cyclopropylbenzoate. To a round-bottomed flask under N2 was added zinc dust (0.80 g, 12.5 mmol, Aldrich), cuprous chloride (1.23 g, 12.5 mmol, Aldrich) and Et2O (2 mL). The mixture was magnetically stirred and heated at reflux for 30 min. The suspension was treated with ethyl 4-vinylbenzoate (0.85 g, 4.82 mmol, Apin) followed by methylene diiodide (1.68 g, 6.27 mmol, Aldrich) and reflux was continued for 24 h. The reaction mixture was allowed to cool to 25° C., filtered, concentrated in vacuo and purified by silica gel chromatography (9:1 hexane:EtOAc) to provide the title product. MS (ESI, pos. ion) m/z: 191 (M+1).
    Figure US20060030618A1-20060209-C00202
  • (b) 4-Cyclopropylbenzaldehyde. Ethyl 4-cyclopropylbenzoate, Example 43(a), (316 mg, 1.66 mmol) was transferred to a round-bottomed flask and treated with lithium aluminum hydride (0.30 mL, 3.0 mmol, 1.0 M in THF, Aldrich) under N2. The reaction mixture was magnetically stirred at 25° C. for 1 h, then quenched by the dropwise addition of H2O (0.5 mL) followed by 20% aq. KOH (3 mL). The suspension was filtered and the aqueous phase extracted with EtOAc. The organic extract was concentrated in vacuo and the crude alcohol was redissolved in anhydrous CH2Cl2 (2 mL). In a separate round-bottomed flask, a solution of oxalyl chloride (2.0 mL, 4.0 mmol, 2.0 M in CH2Cl2, Aldrich) was magnetically stirred under N2 at −78° C. and treated dropwise with a solution of anhydrous dimethyl sulfoxide (4.0 mL, 56 mmol, Aldrich) in anhydrous CH2Cl2 (2 mL). The reaction mixture was stirred at −78° C. for 5 min then treated dropwise with the solution of crude alcohol in CH2Cl2. The reaction mixture was stirred an additional 5 min at −78° C., treated with triethylamine (2.0 mL, 14 mmol), allowed to warm to 25° C. and stirred at that temperature for 1 h. The reaction was quenched by the addition of H2O and the mixture was extracted with Et2O. The organic extract was concentrated in vacuo to provide 230 mg (95% over two steps) of the title product.
    Figure US20060030618A1-20060209-C00203
  • (c) (2E)-3-(4-Cyclopropylphenyl)prop-2-enoic acid. Analogous to the procedure described for Example 40, step (a), 4-cyclopropylbenzaldehyde, Example 43(b), (0.23 g, 1.6 mmol) and triethyl phosphonoacetate (0.35 g, 1.6 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 189 (M+1).
  • (d) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-(4-cyclopropylphenyl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-(4-cyclopropylphenyl)prop-2-enoic acid, Example 43(c), (130 mg, 0.69 mmol) and 1,4-benzodioxan-6-amine (104 mg, 0.69 mmol, Aldrich) provided, after purification by silica gel chromatography (65:35 hexane:EtOAc), the title product as a clear glass. MS (ESI, pos. ion) m/z: 322 (M+1).
    • EXAMPLE 44
  • Figure US20060030618A1-20060209-C00204
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[6-(tert-butyl)(3-pyridyl)]-prop-2-enamide
  • Figure US20060030618A1-20060209-C00205
  • (a) 6-(tert-Butyl)pyridine-3-carbaldehyde. Analogous to the procedure of Rybakova, et al. Zh. Org. Khim. 1995, 31(5), 670-673, pyridine-3-methanol (2.18 g, 20.0 mmol, Aldrich), trimethylacetic acid (10.2 g, 100 mmol, Aldrich), silver nitrate (0.68 gm 4.0 mmol, Aldrich), and 10% aq. sulfuric acid (20 mL) were combined in a round-bottomed flask. The reaction mixture was magnetically stirred and treated with a solution of ammonium persulfate (9.1 g, 40 mmol, Aldrich) in H2O (40 mL). Evolution of gas was observed and the reaction mixture was stirred at 25° C. for 2 h. The reaction mixture was basified to pH 9 by the addition of aq. ammonium hydroxide then extracted with EtOAc. The organic extract was washed with H2O, dried over Na2SO4, filtered and concentrated in vacuo. Purification of the crude product by silica gel chromatography (70:30 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 164 (M+1).
    Figure US20060030618A1-20060209-C00206
  • (b) (2E)-3-[6-(tert-Butyl)(3-pyridyl)]prop-2-enoic acid. Analogous to the procedure described for Example 40, step (a), 6-(tert-butyl)pyridine-3-carbaldehyde, Example 44(a), (0.55 g, 3.4 mmol) and triethyl phosphonoacetate (0.76 g, 3.4 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 206 (M+1).
  • (c) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[6-(tert-butyl)(3-pyridyl)]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)(3-pyridyl)]prop-2-enoic acid, Example 44(b), (200 mg, 1.0 mmol) and 1,4-benzodioxan-6-amine (150 mg, 1.0 mmol, Aldrich) provided, after purification by silica gel chromatography (60:40 hexane:EtOAc), the title product as a clear glass. MS (ESI, pos. ion) m/z: 339 (M+1).
    • EXAMPLE 45
  • Figure US20060030618A1-20060209-C00207
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[3-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00208
  • (a) 3-(tert-Butyl)benzaldehyde. To a round-bottomed flask equipped with magnetic stirring was added 1-tert-butyl-3-methylbenzene (1 g, 6.8 mmol, Wiley), ammonium cerium (IV) nitrate (17.5 g, 29.7 mmol, Aldrich) and 50% aq. acetic acid (150 mL). The reaction mixture was stirred and heated at 90° C. for 1.5 h. The reaction mixture was allowed to cool to 25° C. and extracted with 10% EtOAc in hexane. The organic extract was concentrated in vacuo to provide the crude aldehyde.
    Figure US20060030618A1-20060209-C00209
  • (b) (2E)-3-[3-(tert-Butyl)phenyl]prop-2-enoic acid. Analogous to the procedure described for Example 40, step (a), 3-(tert-butyl)benzaldehyde, Example 45(a), (320 mg, 2.0 mmol) and triethyl phosphonoacetate (250 mg, 2.0 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 205 (M+1).
  • (c) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[3-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[3-(tert-butyl)phenyl]prop-2-enoic acid, Example 45(b), (200 mg, 1.0 mmol) and 1,4-benzodioxan-6-amine (150 mg, 1.0 mmol, Aldrich) provided, after purification by silica gel chromatography (60:40 hexane:EtOAc), the title product. MP 168° C. MS (ESI, pos. ion) m/z: 338 (M+1).
    • EXAMPLE 46
  • Figure US20060030618A1-20060209-C00210
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[2-fluoro-4-(trifluoromethyl)-phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00211
  • (a) [2-Fluoro-4-(trifluoromethyl)phenyl]methan-1-ol. To a round-bottomed flask, equipped with magnetic stirring and a reflux condenser, was added 2-fluoro-4-(trifluoromethyl)benzoic acid (5.0 g, 24 mmol, ABCR) and borane-THF complex (72 mL, 72 mmol, 1.0 M in THF, Aldrich) at 0° C. under N2. The reaction mixture was warmed to 65° C. and stirred at that temperature for 2 h. The reaction mixture was allowed to cool to 25° C. and the solvent was removed in vacuo. The resulting residue was dissolved in CH2Cl2 (100 mL) and washed with satd Na2CO3 (100 mL). The aqueous phase was back-extracted with CH2Cl2 (4×80 mL). The combined organic extract was washed with satd NaCl (200 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (gradient: 0-10% EtOAc in hexane) provided the title product as a colorless oil.
    Figure US20060030618A1-20060209-C00212
  • (b) 2-Fluoro-4-(trifluoromethyl)benzaldehyde. To a solution of [2-fluoro-4-(trifluoromethyl)phenyl]methan-1-ol, Example 46(a), (4.4 g, 23 mmol) in CH2Cl2 (100 mL) was added ground pyridinium dichromate (38.4 g, 102 mmol, Fluka). The reaction mixture was stirred at 25° C. overnight, then filtered through Celite. The Celite pad was washed with CH2Cl2 (2×50 mL) and the combined filtrate was concentrated in vacuo. Purification by silica gel chromatography (gradient: 0-5% EtOAc in hexane) provided the title product as a white slurry.
    Figure US20060030618A1-20060209-C00213
  • (c) Methyl (2E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoate. 2-Fluoro-4-(trifluoromethyl)benzaldehyde, Example 46(b), (900 mg, 4.7 mmol) in CH2Cl2 (5 mL) was added via cannula to a solution of carbomethoxymethylene triphenylphosphorane (2.0 g, 6.1 mmol, Aldrich) in CH2Cl2 (15 mL), magnetically stirred in a round-bottomed flask at 0° C. The reaction mixture was allowed to warm to 25° C. and stirred at this temperature under N2 overnight. The solvent was removed in vacuo and the crude material purified by silica gel chromatography (gradient: 0-5% EtOAc in hexane) to provide the title product as a white solid.
    Figure US20060030618A1-20060209-C00214
  • (d) (2E)-3-[2-Fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic acid. Methyl (2E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoate, Example 46(c), (1.6 g, 6.3 mmol) was treated with lithium hydroxide monohydrate (530 mg, 12.6 mmol, Aldrich) in wet EtOH (15 mL) and magnetically stirred in a round-bottomed flask at 25° C. overnight. The reaction mixture was acidified to pH <2 with 10% aq. HCl and extracted with EtOAc (3×50 mL). The combined extracts were washed with satd NaCl (100 mL), dried over Na2SO4, filtered and concentrated in vacuo to provide the acid as a white solid.
  • (e) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[2-fluoro-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 46(d), (200 mg, 0.85 mmol) and 1,4-benzodioxan-6-amine (193 mg, 1.28 mmol, Aldrich) provided, after purification by silica gel chromatography (gradient: 0-20% EtOAc in hexane) and recrystallization from EtOAc and hexane, the title product as a yellow crystalline solid. MP 174-175° C. MS (ESI, pos. ion) m/z: 368 (M+1).
    • EXAMPLE 47
  • Figure US20060030618A1-20060209-C00215
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[2,3-difluoro-4-(trifluoro-methyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 46, steps (b)-(e), the title product was obtained from 2,3-difluoro-4-(trifluoromethyl)benzyl alcohol (ABCR) and 1,4-benzodioxan-6-amine (Aldrich) as a crystalline yellow solid. MP 169-170° C. MS (ESI, pos. ion) m/z: 386 (M+1).
    • EXAMPLE 48
  • Figure US20060030618A1-20060209-C00216
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[2,4-bis(trifluoromethyl)-phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 46, steps (b)-(e), the title product was obtained from 2,4-bis(trifluoromethyl)benzyl alcohol (Avocado) and 1,4-benzodioxan-6-amine (Aldrich) as a crystalline yellow solid. MP 204-205° C. MS (ESI, pos. ion) m/z: 418 (M+1).
    • EXAMPLE 49
  • Figure US20060030618A1-20060209-C00217
    • (2E)-3-[2-Fluoro-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide
  • Analogous to the procedure used to prepare Example 46, steps (a)-(e), the title product was obtained from 2-fluoro-4-(trifluoromethyl)benzoic acid (ABCR) and 5-aminoindole (Aldrich) as a crystalline yellow solid. MP 203-205° C. MS (ESI, pos. ion) m/z: 349 (M+1).
    • EXAMPLE 50
  • Figure US20060030618A1-20060209-C00218
    • (2E)-3-[2,3-Difluoro-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide
  • Analogous to the procedure used to prepare Example 46, steps (b)-(e), the title product was obtained from 2,3-difluoro-4-(trifluoromethyl)benzyl alcohol (ABCR) and 5-aminoindole (Aldrich) as a crystalline yellow solid. NM 220-222° C. MS (ESI, pos. ion) m/z: 367 (M+1).
    • EXAMPLE 51
  • Figure US20060030618A1-20060209-C00219
    • (2E)-3-[2,4-Bis(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide
  • Analogous to the procedure used to prepare Example 46, steps (b)-(e), the title product was obtained from 2,4-bis(trifluoromethyl)benzyl alcohol (Avocado) and 5-aminoindole (Aldrich) as a crystalline yellow solid. MP 207-209° C. MS (ESI, pos. ion) m/z: 399 (M+1).
    • EXAMPLE 52
  • Figure US20060030618A1-20060209-C00220
    • N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00221
  • (a). Ethyl 3-[4-(tert-butyl)phenyl]prop-2-ynoate. To a 1 L round-bottomed flask was added (4-tert-butyl)phenylacetylene (33.8 g, 214 mmol, GFS Chemicals) and anhydrous THF (220 mL). The solution was magnetically stirred, purged with N2 and cooled to −78° C., then n-butyllithium (136 mL, 2.5 M in hexanes, Aldrich) was added slowly. After the addition was complete, the mixture was gradually warmed to 0° C. and stirred magnetically for 30 min. The reaction mixture was cooled to −78° C. again and ethyl chloroformate (28.6 mL, 299.2 mmol, Aldrich) was added. After allowing to warm to 25° C. and stirring overnight, the reaction was quenched with 1:1 satd NaHCO3:satd NH4Cl (200 mL) and extracted with Et2O (1000 mL). The organic phase was dried over Na2SO4, filtered and concentrated in vacuo to afford a yellow oil. Purification by silica gel chromatography (gradient: 0.5%-3% EtOAc/hexane) provided ethyl 3-[4-(tert-butyl)phenyl]prop-2-ynoate as a pale yellow oil. MS (ESI, pos. ion) m/z: 231 (M+1).
    Figure US20060030618A1-20060209-C00222
  • (b). Ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enoate. According to the procedure of E. Piers et al., Can. J. Chem. 1994, 72, 1816, to a 150 mL round-bottomed flask equipped with a reflux condenser and magnetic stirring was added ethyl 3-[4-(tert-butyl)phenyl]prop-2-ynoate, Example 52(a), (15 g, 65 mmol), sodium iodide (31 g, 209 mmol, Aldrich) and glacial acetic acid (48 mL, 830 mmol). The reaction mixture was purged with N2 and the flask immersed in a pre-heated 115° C. oil bath. The reaction mixture was magnetically stirred at 115° C. for 4 h, then allowed to cool to 25° C. and treated with H2O (200 mL). The aqueous phase was extracted with Et2O (500 mL). The organic layer was washed with satd Na2CO3 until the evolution of CO2 ceased, then washed with 1 M Na2S2O3 (100 mL), satd NaCl, dried over Na2SO4, filtered, and concentrated in vacuo to provide ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enoate as a yellow oil. MS (ESI, pos. ion) m/z: 359 (M+1).
    Figure US20060030618A1-20060209-C00223
  • (c) Ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoate. To a 100 mL round-bottomed flask equipped with a reflux condenser and magnetic stirring was added ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enoate, Example 52(b), (0.75 g, 2.1 mmol), 4-trifluoromethylphenylboronic acid (0.60 g, 3.1 mmol, Aldrich), tetrakis(triphenylphosphine)palladium (0) (0.24 g, 0.21 mmol, Aldrich), toluene (10 mL), EtOH (2 mL), and 2 M aq. Na2CO3 (2 mL). The reaction mixture was magnetically stirred at 80° C. under N2 overnight, allowed to cool to 25° C. and diluted with EtOAc (50 mL). The organic layer was separated, washed with H2O, satd NaCl (50 mL), dried over Na2SO4, filtered and concentrated to afford a brown oil. Purification by silica gel chromatography (gradient: 1.5%-2% EtOAc/hexane) provided the title product as a white solid. MS (ESI, pos. ion) m/z: 377 (M+1).
    Figure US20060030618A1-20060209-C00224
  • (d) (2Z)-3-[4-(tert-Butyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoic acid. To a 50 mL round-bottomed flask equipped with a reflux condenser was added ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoate, Example 52(c), (0.74 g, 2.0 mmol), 1,4-dioxane (3 mL), KOH (0.66 g, 12 mmol) and H2O (1.5 mL). The reaction mixture was heated and magnetically stirred under reflux overnight then diluted with H2O (20 mL) and acidified with 1 N HCl. The aqueous mixture was extracted with CH2Cl2 (3×100 mL). The organic phase was dried over Na2SO4, filtered and concentrated in vacuo to provide the title product as a white solid. MS (ESI, pos. ion) m/z: 349 (M+1).
  • (e) N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2Z)-3-[4-(tert-butyl)phenyl]-3-[4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 52(d), (0.15 g, 0.43 mmol) and 1,4-benzodioxan-6-amine (0.07 g, 0.43 mmol, Aldrich) provided, after purification by silica gel chromatography (gradient: 10%-18% EtOAc/hexane), the title product as a pale yellow solid. MP 150-151° C. MS (ESI, pos. ion) m/z: 482 (M+1).
    • EXAMPLE 53
  • Figure US20060030618A1-20060209-C00225
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-4-phenylbut-2-enamide
  • Figure US20060030618A1-20060209-C00226
  • (a) Ethyl (2E)-3-[4-(tert-butyl)phenyl]-4-phenylbut-2-enoate. A solution of ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enoate, Example 52(b), (710 mg, 2.0 mmol) in anhydrous DMF (4 mL) was added dropwise to benzylzinc bromide (12 mL, 6.0 mmol, 0.5 M solution in TBF, Aldrich) magnetically stirred under Ar at 0° C. in a round-bottomed flask. The mixture was treated with bis(acetonitrile)dichloropalladium (II) (78 mg, 0.30 mmol, Aldrich) in one portion. The reaction mixture was then magnetically stirred for 16 h at 25° C., diluted with Et2O (100 mL) and washed with 1N HCl (25 mL) and satd NaCl (25 mL). The organic phase was dried over MgSO4, filtered and concentrated in vacuo and the residue purified by silica gel chromatography (49:1 hexane:EtOAc) to provide the title product as a colorless oil. MS (ESI, pos. ion) m/z: 323 (M+1).
    Figure US20060030618A1-20060209-C00227
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-4-phenylbut-2-enoic acid. Ethyl (2E)-3-[4-(tert-butyl)phenyl]-4-phenylbut-2-enoate, Example 53(a), (530 mg, 1.8 mmol) was treated with KOH (0.22 g, 4.0 mmol), H2O (4 mL) and 1,4-dioxane (2 mL), then magnetically stirred under reflux for 16 h. The reaction mixture was diluted with H2O (50 mL), acidified with 1 N HCl and extracted with chloroform. The combined organic extract was washed with satd NaCl, dried over MgSO4, filtered and concentrated in vacuo. The resulting residue was crystallized from EtOAc and hexane to provide the title product as a white solid.
  • (c) (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-4-phenylbut-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[4-(tert-butyl)phenyl]-4-phenylbut-2-enoic acid, Example 53(b), (250 mg, 0.85 mmol) and 1,4-benzodioxan-6-amine (140 mg, 0.93 mmol, Aldrich) provided, after purification by silica gel chromatography (chloroform), the title product as off-white needles. MP 97-99° C. MS (ESI, pos. ion) m/z: 428 (M+1).
    • EXAMPLE 54
  • Figure US20060030618A1-20060209-C00228
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-5-methylhex-2-enamide
  • Analogous to the procedure used to prepare Example 53, starting from 3-methylbutylzinc bromide (Aldrich), ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enoate, Example 52(b), and 1,4-benzodioxan-6-amine (Aldrich), the title product was obtained as an off-white solid. MP 123° C. MS (ESI, pos. ion) m/z: 394 (M+1).
    • EXAMPLE 55
  • Figure US20060030618A1-20060209-C00229
    • N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enamide
  • Figure US20060030618A1-20060209-C00230
  • (a) 3-[4-(tert-Butyl)phenyl]prop-2-ynoic acid. To a round-bottomed flask equipped with magnetic stirring and a reflux condenser was added a solution of ethyl 3-[4-(tert-butyl)phenyl]prop-2-ynoate, Example 52(a), (4.6 g, 20 mmol) in 1,4-dioxane (5 mL). The solution was treated with H2O (15 mL) and KOH (2.2 g, 40 mmol) then stirred and heated at reflux under Ar for 18 h. After allowing to cool to 25° C., the mixture was diluted with H2O (200 mL) and washed with Et2O (50 mL). The aqueous phase was separated, acidified with 1 N HCl and extracted with chloroform. The chloroform extract was washed with satd NaCl, dried over MgSO4, filtered and concentrated in vacuo. Crystallization from EtOAc and hexane provided the title product as white needles. MS (ESI, pos. ion) m/z: 203 (M+1).
    Figure US20060030618A1-20060209-C00231
  • (b) N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-ynamide. Analogous to the procedure used to prepare Example 1, 3-[4-(tert-butyl)phenyl]prop-2-ynoic acid, Example 55(a), (404 mg, 2.0 mmol) and 1,4-benzodioxan-6-amine (330 mg, 2.2 mmol, Aldrich) provided the title product as a white solid. MP 199° C. MS (ESI, pos. ion) m/z: 336 (M+1).
  • (c) N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enamide. Analogous to the procedure described for the preparation of Example 52(b), N-(2H,3H-benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-ynamide, Example 55(b), (0.335 g, 1.0 mmol), sodium iodide (0.48 g, 3.2 mmol, Aldrich) and glacial acetic acid (0.73 mL) provided, after purification by silica gel chromatography (chloroform), the title product as yellow crystals. MP 164° C. MS (ESI, pos. ion) m/z: 464 (M+1).
    • EXAMPLE 56
  • Figure US20060030618A1-20060209-C00232
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-(3-aminophenyl)-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 52, step (c), 3-aminophenylboronic acid (0.23 g, 1.5 mmol, Avocado) and N-(2H,3H-benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enamide, Example 55, (0.46 g, 1.0 mmol) provided the title product as off-white crystals. MP 140° C. MS (ESI, pos. ion) m/z: 429 (M+1).
    • EXAMPLE 57
  • Figure US20060030618A1-20060209-C00233
    • Ethyl (4E)-5-(N-(2H,3H-benzo[e]1,4-dioxan-6-yl)carbamoyl)-4-[4-(tert-butyl)phenyl]pent-4-enoate
  • Analogously to the procedure used to prepare Example 53, step (a), 3-ethoxy-3-oxopropylzinc bromide (6.0 mL, 3.0 mmol, 0.5 M in THF, Aldrich) and N-(2H,3H-benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enamide, Example 55, (0.46 g, 1.0 mmol) provided the title product as a pale yellow solid. MP 104-105° C. MS (ESI, pos. ion) m/z: 438 (M+1).
    • EXAMPLE 58
  • Figure US20060030618A1-20060209-C00234
  • 3-Methoxyphenyl (2E)-3-[4-(tert-butyl)phenyl]prop-2-enoate. To a 100 mL round-bottomed flask equipped with magnetic stirring was added 4-tert-butyl-trans-cinnamic acid (500 mg, 2.45 mmol, EMKA-Chemie), CH2Cl2 (10 mL), and DMF (10 uL) under N2. The solution was treated dropwise with oxalyl chloride (4.0 mL, 8.0 mmol, 2.0 M in CH2Cl2, Aldrich) then stirred at 25° C. for 1 h. The reaction mixture was concentrated in vacuo and the residue treated with 3-methoxyphenol (269 uL, 2.45 mmol, Aldrich), THF (20 mL) and satd K2CO3 (15 mL). The reaction mixture was stirred at 25° C. overnight, then acidified to pH 4.5 with 1 N HCl. The mixture was extracted with EtOAc (2×30 mL), the combined organic extract was dried and concentrated in vacuo. Purification by silica gel chromatography (5:1 hexane:EtOAc) provided the title product as a white solid. MP 83° C. MS (ESI, pos. ion) m/z: 311 (M+1).
    • EXAMPLE 60
  • Figure US20060030618A1-20060209-C00235
    • N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-hydroxyprop-2-enamide
  • Figure US20060030618A1-20060209-C00236
  • (a) tert-Butyl3-[4-(tert-butyl)phenyl]-3-hydroxypropanoate. To a round-bottomed flask equipped with magnetic stirring was added N,N-diisopropylamine (10.4 mL, 74.0 mmol, Aldrich) and anhydrous THF (20 mL). The solution was stirred at −78° C. under N2 and treated dropwise with n-butyllithium (30.0 mL, 75.0 mmol, 2.5 M in hexane, Aldrich). After stirring for 10 min at −78° C., the reaction mixture was treated with t-butyl acetate (10.8 mL, 80.1 mmol, Aldrich). After stirring 30 min at −78° C., the enolate was added via cannula to a solution of 4-t-butylbenzaldehyde (10.0 g, 61.6 mmol, Fluka) in anhydrous THF (100 mL), stirred under N2 at −78° C. The reaction mixture was allowed to warm to 0° C. with stirring over 3 h, then quenched with satd NHFCl and concentrated in vacuo to remove the THF. The resulting mixture was diluted with satd NH4Cl (100 mL) and extracted with Et2O (200 mL). The organic extract was washed with H2O (100 mL), satd NaCl (50 mL), dried over MgSO4, filtered and concentrated in vacuo to provide the title product as a white solid. MS (ESI, pos. ion) m/z: 261 (M+1-H2O).
    Figure US20060030618A1-20060209-C00237
  • (b) tert-butyl 3-[4-(tert-butyl)phenyl]-3-oxopropanoate. tert-Butyl 3-[4-(tert-butyl)phenyl]-3-hydroxypropanoate, Example 60(a), (5.0 g, 18 mmol) was dissolved in CH2Cl2 (100 mL), magnetically stirred in a round-bottomed flask at 0° C., and treated with pyridinium chlorochromate (5.8 g, 27 mmol, Aldrich) in portions. The reaction mixture was allowed to warm to 25° C. and stirred at that temperature for 5 h. The mixture was filtered through a pad of Celite, the filtercake washed with CH2Cl2 (3×100 mL) and the combined filtrate was concentrated in vacuo. Purification by silica gel chromatography (1:1 hexane:EtOAc) provided the title product as a dark oil. MS (ESI, pos. ion) m/z: 277 (M+1).
  • (c) N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-hydroxyprop-2-enamide. According to the procedure of Wiseman et al., J. Org. Chem. 1991, 56, 1713-1718, to a round-bottomed flask equipped with magnetic stirring and a reflux condenser was added tert-butyl 3-[4-(tert-butyl)phenyl]-3-oxopropanoate, Example 60(b), (640 mg, 2.3 mmol), 1,4-benzodioxan-6-amine (350 mg, 2.3 mmol, Aldrich) and anhydrous toluene (20 mL). The mixture was stirred and heated at 130° C. for 2 h. Upon allowing to cool to 25° C., a precipitate was observed. Hexane (20 mL) was added to the suspension and the precipitate collected by filtration, washed with hexane (20 mL) and dried in vacuo at 60° C. to provide the title product as a pale grey solid. MP 161° C. MS (ESI, pos. ion) m/z: 354 (M+1).
    • EXAMPLE 61
  • Figure US20060030618A1-20060209-C00238
    • N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)[7-(tert-butyl)(3-isoquinolyl)]-carboxamide
  • Figure US20060030618A1-20060209-C00239
  • (a) 2-[(tert-Butyl)oxycarbonyl]-7-(tert-butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid. According to the procedure of D. Ma, et al., Bioorg. Med. Chem. Lett. 1998, 8(18), 2447-2450, to a 250 mL round-bottomed flask, equipped with magnetic stirring and reflux condenser, was added N-Boc-(p-tert-butyl)-S-phenylalanine (5.0 g, 15.6 mmol, Bachem), formaldehyde (50 mL, 37 wt. % in H2O, Aldrich) and cond HCl (30 mL). The reaction mixture was stir-red and heated at 90° C. for 4 h. The solvents were removed in vacuo to provide 3.6 g of a residue [MS (ESI, pos. ion) m/z: 234 (M+1)] which was dissolved in THF (140 mL) and treated with 5% aq. K2CO3 (140 mL) and di-t-butyl dicarbonate (4.8 g, 22 mmol, Aldrich). The reaction mixture was stirred at 25° C. overnight, then acidified to pH 5 with 1 N HCl. The mixture was extracted with EtOAc (300 mL), the organic phase washed with satd NaCl (100 mL) and H2O (120 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (2:1 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 334 (M+1).
  • (b) N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)[7-(tert-butyl)(3-1,2,3,4-tetrahydroisoquinolyl)]carboxamide hydrochloride. To a 250 mL round-bottomed flask equipped with magnetic stirring was added 2-[(tert-butyl)oxycarbonyl]-7-(tert-butyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, Example 61(a), (1.5 g, 4.65 mmol), DMF (15 mL), 1,4-benzodioxan-6-amine (700 mg, 4.65 mmol, Aldrich), dimethylaminopropyl-3-ethylcarbodiimide hydrochloride (1.25 g, 6.5 mmol, Aldrich) and N,N-diisopropylethylamine (2.5 mL, 13.95 mmol, Aldrich). The reaction mixture was stirred at 25° C. overnight then concentrated in vacuo. The residue was dissolved in EtOAc (35 mL), washed with H2O (2×15 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (3:1 hexane:EtOAc) provided a product [MS (ESI, pos. ion) m/z: 467 (M+1)] which was treated with 4.0 N HCl in 1,4 dioxane (10 mL, Aldrich) and stirred at 25° C. for 1 h. The solvent was removed in vacuo to provide the title product as the hydrochloride salt. MP 134° C. MS (ESI, pos. ion) m/z: 367 (M+1).
  • (c) N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)[7-(tert-butyl)(3-isoquinolyl)]-carboxamide. Analogous to the procedure of E. D. Cox; T. J. Hagen; R. M. McKernan; J. M. Cook, Med. Chem. Rest. 1995, 5(9), 710-718, N-(2H,3H-benzo[3,4-e]1,4-dioxan-6-yl)[7-(tert-butyl)(3-1,2,3,4-tetrahydroisoquinolyl)]carboxamide hydrochloride, Example 61(b), was suspended in EtOAc (55 mL), washed with 10% NaHCO3 (20 mL) and H2O (10 mL), dried over Na2SO4, filtered and concentrated in vacuo. The resulting residue (80 mg, 0.22 mmol) was dissolved in toluene (10 mL) and treated with manganese dioxide (110 mg, 1.1 mmol). The reaction mixture was magnetically stirred at 70° C. under N2 for 1.5 h, filtered through Celite and concentrated in vacuo. Purification by silica gel chromatography (8:1 hexane:EtOAc) provided the title product as a yellow solid. MP 154-157° C. MS (ESI, pos. ion) m/z: 363 (M+1).
    • EXAMPLE 63
  • Figure US20060030618A1-20060209-C00240
    • N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00241
  • (a) (2Z)-3-[4-(tert-Butyl)phenyl]prop-2-enoic acid. Potassium bis(trimethylsilyl)amide (6.1 mL, 3.05 mmol, 0.5 M in toluene, Aldrich) was added dropwise with stirring to a mixture of diphenylphosphonoacetic acid ethyl ester (0.98 g, 3.05 mmol, TCI-US) and 18-crown-6 (3.35 g, 12.7 mmol, Aldrich) in anhydrous THF (20 mL), magnetically stirred at −78° C. under Ar. The reaction mixture was stirred at −78° C. for 0.5 h then treated dropwise with a solution of 4-tert-butylbenzaldehyde (0.42 mL, 2.54 mmol, Aldrich) in anhydrous THF (5 mL). The mixture was stirred at −78° C. for 1 h, quenched with satd NH4Cl (5 mL), warmed to 25° C., diluted with H2O (50 mL) and extracted with EtOAc (2×50 mL). The combined organic extracts were washed with satd NaCl, dried over MgSO4, filtered and concentrated in vacuo to provide a brown viscous oil. [MS (ESI, pos. ion) m/z: 233 (M+1)] The oil (0.83 g) was dissolved in THF (5 mL) and MeOH (5 mL), magnetically stirred in a round-bottomed flask at 25° C., and treated with 1 N LiOH (10 mL). The reaction mixture was stirred at 25° C. for 18 h, the organic solvents removed in vacuo, and the aqueous phase was washed with Et2O, acidified with 10% citric acid and extracted with EtOAc (3×10 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated in vacuo to provide the title product as a white solid. MS (ESI, pos. ion) m/z: 205 (M+1).
  • (b) N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2Z)-3-[4-(tert-butyl)phenyl]prop-2-enoic acid, Example 63(a), (0.46 g, 2.3 mmol) and 1,4-benzodioxan-6-amine (0.38 g, 2.58 mmol, Aldrich) provided the title product as a white solid. MP 114-116° C. MS (ESI, pos. ion) m/z: 338 (M+1).
    • EXAMPLE 64
  • Figure US20060030618A1-20060209-C00242
    • N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-phenylprop-2-enamide
  • N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-ynamide, Example 55(b), (0.34 g, 1.0 mmol) was dissolved in anhydrous EtOAc (50 mL) in a 100 mL round-bottomed flask equipped with reflux condenser and magnetic stirring under dry nitrogen atmosphere. To this solution was added iodobenzene (0.20 g, 1.0 mmol, Aldrich) and bis(dibenzylideneacetone)palladium (0.080 g, 0.14 mmol, Acros), followed by diethylamine (0.34 mL, 3.3 mmol, Aldrich) and formic acid (0.098 mL, 2.6 mmol, Aldrich). The reaction mixture was heated under reflux for 20 h, cooled to room temperature, washed with 1 N HCl (2×5 mL), 1 N NaOH (2×5 mL), satd NaCl (5 mL) and dried over Na2SO4. The organic solution was filtered and concentrated to afford a brown oil which was purified by silica gel chromatography (20 % EtOAc/hexane) to give the title compound as a pale yellow solid. MP 80-82° C. MS (ESI, pos. ion) m/z: 414 (M+1).
    • EXAMPLE 65
  • Figure US20060030618A1-20060209-C00243
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-3-phenylprop-2-enamide
  • Figure US20060030618A1-20060209-C00244
  • (a). N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-phenylprop-2-ynamide. Analogous to the procedure used to prepare Example 1, phenylpropiolic acid (5.8 g, 140 mmol, Aldrich) and 1,4-benzodioxan-6-amine (6.65 g, 44 mmol, Aldrich) provided, after recrystallization from EtOAc and hexane, the title compound as a white solid. MP 132° C. MS (ESI, pos. ion) m/z: 280 (M+1).
  • (b). (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-3-phenylprop-2-enamide. Analogous to the procedure used to prepare Example 64, 1-tert-butyl-4-iodobenzene (0.26 g, 1.0 mmol, Aldrich) and N-(2H,3H-benzo[e]1,4-dioxan-6-yl)-3-phenylprop-2-ynamide, Example 65(a), (0.28 g, 1.0 mmol) provided, after recrystallization from EtOAc and hexane, the title compound as an off-white solid. MP 139° C. MS (ESI, pos. ion) m/z: 414 (M+1).
    • EXAMPLE 66
  • Figure US20060030618A1-20060209-C00245
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(N-methylcarbamoyl)(1H-indazol-6-yl)]prop-2-enamide
  • To a round-bottomed flask, equipped with a magnetic stir bar, was added (2E)-N-(1H-indazol-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide, Example 155, (61 mg, 0.19 mmol), THF (8 mL) and isocyanatomethane (54 mg, 0.96 mmol, Carbolabs). The reaction mixture was stirred at room temperature for 8 h. The reaction mixture was diluted with EtOAc (10 mL), washed with water (8 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (40:20:1 hexane:EtOAc:MeOH) provided the title product as an off-white solid. MN 208-209° C. MS (ESI, pos. ion) m/z: 377 (M+1).
    • EXAMPLE 67
  • Figure US20060030618A1-20060209-C00246
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-{4-chloro-3-[(methylamino)carbonylamino]-phenyl}prop-2-enamide
  • Figure US20060030618A1-20060209-C00247
  • (a) (2E)-N-(3-Amino-4-chlorophenyl)-3-[4-(tert-butyl)phenyl]prop-2-enamide. To a round-bottomed flask equipped with a magnetic stir bar, was added (2E)-3-[4-(tert-butyl)phenyl]-N-(4-chloro-3-nitrophenyl)prop-2-enamide, Example 156, (250 mg, 0.69 mmol), EtOH (8 mL), indium (800 mg, 6.9 mmol, Aldrich) and satd NH4Cl (10 mL). The reaction mixture was stirred at reflux for 5 h. The solvents were removed in vacuo, the residue was dissolved in EtOAc (20 mL), washed with water (20 mL), dried over Na2SO4, filtered and concentrated in vacuo to yield the title product. MS (ESI, pos. ion) m/z: 329 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-{4-chloro-3-[(methylamnino)-carbonylamino]phenyl}prop-2-enamide. According to the procedure used to prepare Example 66, (2E)-N-(3-amino-4-chlorophenyl)-3-[4-(tert-butyl)phenyl]prop-2-enamide, Example 67(a), (90 mg, 0.27 mmol) and isocyanatomethane (156 mg, 2.7 mmol, Carbolabs) provided, after purification by silica gel chromatography (2:1 hexane:EtOAc), the title product as an off-white solid. MP 120-122° C. MS (ESI, pos. ion) m/z: 386 (M+1).
    • EXAMPLE 68
  • Figure US20060030618A1-20060209-C00248
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-quinoxalin-6-ylprop-2-enamide
  • Figure US20060030618A1-20060209-C00249
  • (a) Quinoxaline-6-ylamine. To a round-bottomed flask equipped with magnetic stirring was added 4-nitro-1,2-phenylenediamine (1.0 g, 6.5 mmol, Aldrich), acetonitrile (10 mL) and glyoxal (2.2 mL, 19 mmol, 40 wt. % in water, Aldrich). The reaction mixture was allowed to stir at 50° C. for 12 h, then concentrated in vacuo to yield 1.1 g crude 6-nitro-quinoxaline. The crude product was dissolved in methanol, treated with 10% Pd/C (10 mg, Aldrich) and stirred under H2 (1 atm) at 25° C. overnight. The reaction mixture was filtered through Celite and the filtrate was concentrated in vacuo to provide the title product. MS (ESI, pos. ion) m/z: 146 (M+1).
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-quinoxalin-6-ylprop-2-enamide. Analogous to the procedure used to prepare Example 2, 4-tert-butyl-trans-cinnamic acid (100 mg, 0.40 mmol, EMKA-Chemie) and quinoxaline-6-ylamine, Example 68(a), (71 mg, 0.40 mmol) provided, after purification by silica gel chromatography (1:2 hexane:EtOAc), the title product as a yellow solid. MP 229-230° C. MS (ESI, pos. ion) m/z: 332 (M+1).
    • EXAMPLE 69
  • Figure US20060030618A1-20060209-C00250
    • (2E)-N-(1-acetyl(7-1,2,3,4-tetrahydroquinolyl))-3-[4-(tert-butyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00251
  • (a) 1-Acetyl-7-nitro-1,2,3,4-tetrahydroquinoline. A mixture of 7-nitro-1,2,3,4-tetrahydroquinoline, Example 19(a), (0.36 g, 2.0 mmol) and acetic anhydride (3.5 mL, 37 mmol, Aldrich) in a 15 mL round-bottomed flask, was heated at reflux for 1.5 h. The reaction mixture was concentrated in vacuo and the residue was partitioned between EtOAc and 30% ammonium hydroxide. The aqueous layer was extracted with EtOAc (10 mL) and the combined organic layers were dried over Na2SO4, filtered and concentrated in vacuo to give the title compound as a yellow solid. MS (ESI, pos. ion) m/z: 221 (M+1).
    Figure US20060030618A1-20060209-C00252
  • (b) 1-Acetyl-7-amino-1,2,3,4-tetrahydroquinoline. Analogous to the procedure used to prepare Example 3, step (a), 1-acetyl-7-nitro-1,2,3,4-tetrahydroquinoline, Example 69(a), (0.44 g, 2.0 mmol) was converted to the title product. MS (ESI, pos. ion) m/z: 191 (M+1).
  • (c) (2E)-N-(1-acetyl(7-1,2,3,4-tetrahydroquinolyl))-3-[4-(tert-butyl)phenyl]prop-2-enamide. According to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (0.41 g, 2.0 mmol, EMKA Chemie) and 1-acetyl-7-amino-1,2,3,4-tetrahydroquinoline, Example 69(b), (370 mg, 2.0 mmol) provided, after purification by silica gel chromatography (1:1 hexane:EtOAc), the title compound as an amorphous white solid. MS (ESI, pos. ion) m/z: 377 (M+1).
    • EXAMPLE 70
  • Figure US20060030618A1-20060209-C00253
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(2-methoxyethyl)indol-6-yl]prop-2-enamide
  • To a round-bottomed flask was added, (2E)-3-[4-(tert-butyl)phenyl]-N-indol-6-ylprop-2-enamide, Example 189, (320 mg, 1.0 mmol) and anhydrous DMF (20 mL). The solution was stirred magnetically and treated with sodium hydride (0.10 g, 2.5 mmol, 60% dispersion in mineral oil, Aldrich) followed by 2-bromoethyl methyl ether (140 mg, 1.0 mmol, Aldrich). Stirring was continued at 25° C. for 2 h, then the reaction mixture was quenched by the addition of water (50 mL) and extracted with EtOAc. The organic extract was concentrated in vacuo. Purification by silica gel chromatography (60:40 hexane:EtOAc) provided the title compound as a yellow solid. MP 133° C. MS (ESI, pos. ion) m/z: 377 (M+1).
    • EXAMPLE 71
  • Figure US20060030618A1-20060209-C00254
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(2-methoxyethyl)indol-5-yl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 70, 2-bromoethyl methyl ether (140 mg, 1.0 mmol, Aldrich) and (2E)-3-[4-(tert-butyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 161, (320 mg, 0.01 mmol) provided, after purification by silica gel chromatography (65:35 hexane:EtOAc), the title compound as a pale yellow solid. MP 138° C. MS (ESI, pos. ion) m/z: 377 (M+1).
    • EXAMPLE 72
  • Figure US20060030618A1-20060209-C00255
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(2-hydroxyethyl)indol-6-yl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00256
  • (a) 1-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]indole-6-ylamine. Analogous to the procedure used to prepare Example 33, step (a), 6-nitroindole (0.49 g, 3.0 mmol, Aldrich) and (2-bromoethoxy)-tert-butyldimethylsilane (0.72 g, 3.0 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 291 (M+1).
    Figure US20060030618A1-20060209-C00257
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-{1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indol-6-yl}prop-2-enamide. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and 1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indole-6-ylamine, Example 72(a), (290 mg, 1.0 mmol) provided the title product. MS (ESI, pos. ion) m/z: 477 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(2-hydroxyethyl)indol-6-yl]prop-2-enamide. (2E)-3-[4-(tert-Butyl)phenyl]-N-{1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indol-6-yl}prop-2-enamide, Example 72(b), (420 mg, 0.88 mmol) was transferred to a round-bottomed flask and treated with tetrabutylammonium fluoride (2.0 mL, 2.0 mmol, 1.0 M in THF, Aldrich) under N2. The reaction mixture was magnetically stirred at 25° C. for 2 h. The reaction mixture was diluted with water (25 mL) and extracted with EtOAc. The organic extract was concentrated in vacuo. Purification by silica gel chromatography (30:70 hexane:EtOAc) provided the title compound as a yellow solid. MP 178° C. MS (ESI, pos. ion) m/z: 363 (M+1).
    • EXAMPLE 73
  • Figure US20060030618A1-20060209-C00258
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(2-hydroxyethyl)indol-5-yl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00259
  • (a) 1-[2-(1,1,2,2-Tetramethyl-1-silapropoxy)ethyl]indole-5-ylamine. According to the procedure used to prepare Example 33, step (a), 5-nitroindole (0.49 g, 3.0 mmol, Aldrich) and (2-bromoethoxy)-tert-butyldimethylsilane (0.72 g, 3.0 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 291 (M+1).
    Figure US20060030618A1-20060209-C00260
  • (b) (2E)-3-[4-(tert-Butyl)phenyl]-N-{1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indol-5-yl}prop-2-enamide. According to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (100 mg, 0.50 mmol, EMKA-Chemie) and 1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indole-5-ylamine, Example 73(a), (145 mg, 0.50 mmol) provided the title product. MS (ESI, pos. ion) m/z: 477 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-[1-(2-hydroxyethyl)indol-5-yl]prop-2-enamide. According to the procedure used to prepare Example 72, step (c), (2E)-3-[4-(tert-butyl)phenyl]-N-{1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indol-5-yl}prop-2-enamide, Example 73(b), (130 mg, 0.27 mmol) and tetrabutylammonium fluoride(1.0 mL, 1.0 mmol, 1.0 M in THF, Aldrich) provided, after purification by silica gel chromatography (30:70 hexane:EtOAc), the title compound as a pale yellow solid. MP 182° C. MS (ESI, pos. ion) m/z: 363 (M+1).
    • EXAMPLE 74
  • Figure US20060030618A1-20060209-C00261
    • (2E)-3-[4-(tert-Butyl)phenyl]-N-[2-(hydroxymethyl)indol-5-yl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00262
  • (a) Ethyl 5-aminoindole-2-carboxylate. Analogous to the procedure used to prepare Example 3, step (a), ethyl 5-nitroindole-2-carboxylate (2.3 g, 9.9 mmol, Acros) provided the title product. MS (ESI, pos. ion) m/z: 205 (M+1).
    Figure US20060030618A1-20060209-C00263
  • (b) (5-Aminoindol-2-yl)methan-1-ol. Ethyl 5-aminoindole-2-carboxylate, Example 74(a), (1.5 g, 7.3 mmol) was transferred to a round-bottomed flask and treated with lithium aluminum hydride (10 mL, 10 mmol, 1.0 M in THF, Aldrich) under N2. The reaction mixture was magnetically stirred at 25° C. for 1 h, then quenched by the dropwise addition of H2O (0.5 mL) followed by 20% aq. KOH (30 mL). The suspension was filtered and the aqueous phase extracted with EtOAc. The organic extract was concentrated in vacuo. Purification of the crude product by silica gel chromatography (20:80 hexane:EtOAc) provided the title product. MS (ESI, pos. ion) m/z: 163 (M+1).
  • (c) (2E)-3-[4-(tert-Butyl)phenyl]-N-[2-(hydroxymethyl)indol-5-yl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (200 mg, 1.0 mmol, EMKA-Chemie) and (5-aminoindol-2-yl)methan-1-ol, Example 74(b), (160 mg, 1.0 mmol) provided, after purification by silica gel chromatography (40:60 hexane:EtOAc), the title product as a pale tan amorphous solid. MS (ESI, pos. ion) m/z: 349 (M+1).
    • EXAMPLE 75
  • Figure US20060030618A1-20060209-C00264
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enamide
  • Figure US20060030618A1-20060209-C00265
  • (a) Ethyl 6-(tert-butyl)-2-methylpyridine-3-carboxylate. Analogous to the procedure used to prepare Example 44, step (a), ethyl 2-methylnicotinate (8.3 g, 50 mmol, Aldrich), trimethylacetic acid (26 g, 250 mmol, Aldrich), silver nitrate (1.7 g, 10 mmol, Aldrich), 10% aq. sulfuric acid (50 mL) and ammonium persulfate (23 g, 100 mmol, Aldrich) provided, after purification by silica gel chromatography (80:20 hexane:EtOAc), the title product. MS (ESI, pos. ion) m/z: 222 (M+1).
    Figure US20060030618A1-20060209-C00266
  • (b) 6-(tert-Butyl)-2-methylpyridine-3-carbaldehyde. Analogous to the procedure used to prepare Example 43, step (b), ethyl 6-(tert-butyl)-2-methylpyridine-3-carboxylate, Example 75(a), (5.2 g, 23 mmol) provided the title product. MS (ESI, pos. ion) m/z: 178 (M+1).
    Figure US20060030618A1-20060209-C00267
  • (c) (2E)-3-[6-(tert-Butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid. Analogous to the procedure used to prepare Example 40, step (a), 6-(tert-butyl)-2-methylpyridine-3-carbaldehyde, Example 75(b), (3.0 g, 17 mmol) and triethyl phosphonoacetate (4.0 g, 18 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 220 (M+1).
  • (d) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid, Example 75(c), (110 mg, 0.50 mmol) and 1,4-benzodioxan-6-amine (76 mg, 0.50 mmol, Aldrich) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 353 (M+1).
    • EXAMPLE 76
  • Figure US20060030618A1-20060209-C00268
    • (2E)-3-[6-(tert-Butyl)-2-methyl(3-pyridyl)]-N-indol-6-ylprop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid, Example 75(c), (220 mg, 1.0 mmol) and 6-aminoindole (130 mg, 1.0 mmol, Lancaster) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a yellow solid. MP 182° C. MS (ESI, pos. ion) m/z: 334 (M+1).
    • EXAMPLE 77
  • Figure US20060030618A1-20060209-C00269
    • (2E)-N-Benzothiazol-6-yl-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid, Example 75(c), (220 mg, 1.0 mmol) and 6-aminobenzothiazole (150 mg, 1.0 mmol, Lancaster) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a pale yellow amorphous solid. MS (ESI, pos. ion) m/z: 352 (M+1).
    • EXAMPLE 78
  • Figure US20060030618A1-20060209-C00270
    • (2E)-3-[6-(tert-Butyl)-2-methyl(3-pyridyl)]-N-indol-5-ylprop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid, Example 75(c), (0.88 g, 4.0 mmol) and 5-aminoindole (0.53 g, 4.0 mmol, Lancaster) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 334 (M+1).
    • EXAMPLE 79
  • Figure US20060030618A1-20060209-C00271
    • (2E)-3-[6-(tert-Butyl)-2-methyl(3-pyridyl)]-N-[2-(hydroxymethyl)indol-5-yl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)-2-methyl(3-pyridyl)]prop-2-enoic acid, Example 75(c), (110 mg, 0.50 mmol) and (5-aminoindol-2-yl)methan-1-ol, Example 74(b), (81, 0.50 mmol) provided, after purification by silica gel chromatography (25:75 hexane:EtOAc), the title compound as a pale yellow solid. MP 213° C. MS (ESI, pos. ion) m/z: 364 (M+1).
    • EXAMPLE 80
  • Figure US20060030618A1-20060209-C00272
    • (2E)-3-[6-(tert-Butyl)(3-pyridyl)]-N-[2-(hydroxymethyl)indol-5-yl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)(3-pyridyl)]prop-2-enoic acid, Example 44(b), (41 mg, 0.20 mmol) and (5-aminoindol-2-yl)methan-1-ol, Example 74(b), (32 mg, 0.20 mmol) provided, after purification by silica gel chromatography (20:80 hexane:EtOAc), the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 350 (M+1).
    • EXAMPLE 81
  • Figure US20060030618A1-20060209-C00273
    • (2E)-3-[6-(tert-Butyl)(3-pyridyl)]-N-[l-(2-hydroxyethyl)indol-5-yl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00274
  • (a) (2E)-3-[6-(tert-butyl)(3-pyridyl)]-N-{1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indol-5-yl}prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[6-(tert-butyl)(3-pyridyl)]prop-2-enoic acid, Example 44(b), (41 mg, 0.20 mmol) and 1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indole-5-ylamine, Example 73(a), (60 mg, 0.20 mmol) provided the title product. MS (ESI, pos. ion) m/z: 478 (M+1).
  • (b) (2E)-3-[6-(tert-Butyl)(3-pyridyl)]-N-[1-(2-hydroxyethyl)indol-5-yl]prop-2-enamide. Analogous to the procedure used to prepare Example 72, step (c), (2E)-3-[6-(tert-butyl)(3-pyridyl)]-N-{1-[2-(1,1,2,2-tetramethyl-1-silapropoxy)ethyl]indol-5-yl}prop-2-enamide, Example 81(a), (75 mg, 0.16 mmol) and tetrabutylammonium fluoride (0.50 mL, 0.50 mmol, 1.0 M in THF, Aldrich) provided, after purification by silica gel chromatography (20:80 hexane:EtOAc), the title compound as a yellow amorphous solid. MS (ESI, pos. ion) m/z: 364 (M+1).
    • EXAMPLE 82
  • Figure US20060030618A1-20060209-C00275
    • (2E)-N-Indol-6-yl-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enamide
  • Figure US20060030618A1-20060209-C00276
  • (a) 2-Methyl-6-(trifluoromethyl)pyridine-3-carbaldehyde. Analogous to the procedure used to prepare Example 43, step (b), 2-methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid (5.0 g, 24 mmol, Oakwood) provided the title product. MS (ESI, pos. ion) m/z: 190 (M+1).
    Figure US20060030618A1-20060209-C00277
  • (b) (2E)-3-[2-Methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid. Analogous to the procedure used to prepare Example 40, step (a), 2-methyl-6-(trifluoromethyl)pyridine-3-carbaldehyde, Example 82(a), (3.7 g, 20 mmol) and triethyl phosphonoacetate (4.5 g, 20 mmol, Aldrich) provided the title product. MS (ESI, pos. ion) m/z: 232 (M+1).
  • (c) (2E)-N-Indol-6-yl-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid, Example 82(b), (58 mg, 0.25 mmol) and 6-aminoindole (33 mg, 0.25 mmol, Lancaster) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a yellow solid. MP 223° C. MS (ESI, pos. ion) m/z: 346 (M+1).
    • EXAMPLE 83
  • Figure US20060030618A1-20060209-C00278
    • (2E)-N-Indol-5-yl-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid, Example 82(b), (120 mg, 0.50 mmol) and 5-aminoindole (66 mg, 0.50 mmol, Aldrich) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a yellow solid. MP 231° C. MS (ESI, pos. ion) m/z: 346 (M+1).
    • EXAMPLE 84
  • Figure US20060030618A1-20060209-C00279
    • (2E)-N-Benzothiazol-6-yl-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid, Example 82(b), (120 mg, 0.50 mmol) and 6-aminobenzothiazole (75 mg, 0.50 mmol, Lancaster) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a white solid. MP 196° C. MS (ESI, pos. ion) m/z: 364 (M+1).
    • EXAMPLE 85
  • Figure US20060030618A1-20060209-C00280
    • (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[2-methyl-6-(trifluoromethyl)-(3-pyridyl)]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-methyl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid, Example 82(b), (120 mg, 0.50 mmol) and 1,4-benzodioxan-6-amine (76 mg, 0.50 mmol, Aldrich) provided, after purification by silica gel chromatography (55:45 hexane:EtOAc), the title compound as a yellow solid. MP 186° C. MS (ESI, pos. ion) m/z: 365 (M+1).
    • EXAMPLE 86
  • Figure US20060030618A1-20060209-C00281
    • (2E)-3-[4-(tert-butyl)phenyl]-N-[3-(hydroxymethyl)-2-oxo(7-1,3,4-trihydroquinolyl)]prop-2-enamide
  • Figure US20060030618A1-20060209-C00282
  • (a) (2-Amino-4-nitrophenyl)methan-1-ol. To a solution of 4-nitroanthranilic acid (910 mg, 5.0 mmol, Aldrich) in THF (15 mL), magnetically stirred at 0° C., was added borane-tetrahydrofuran complex (15 mL, 15 mmol, 1.0 M in THF, Aldrich) dropwise. The reaction mixture was heated to reflux overnight. The mixture was then cooled to 0° C. and treated dropwise with MeOH (5 mL) followed by 1 N NaOH (30 mL). After stirring for 30 min at room temperature, the mixture was extracted with EtOAc (2×50 mL). The combined organic phases were washed with satd NaCl (20 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (50% EtOAc/hexane) followed by recrystallization from EtOAc/hexane provided the title product. MS (ESI, pos. ion) m/z: 169 (M+1).
    Figure US20060030618A1-20060209-C00283
  • (b) 2-Amino-4-nitrobenzaldehyde. A mixture of 2-amino-4-nitrophenyl)methan-1-ol, Example 86(a), (336 mg, 2.0 mmol) and MnO2 (3.48 g, 40.0 mmol, Aldrich) in CH2Cl2/hexane (1:1, 10 mL) was stirred at room temperature for 1 h. The suspension was filtered and washed with CH2Cl2. The filtrate was concentrated in vacuo to give the crude product. MS (ESI, pos. ion) m/z: 167 (M+1).
    Figure US20060030618A1-20060209-C00284
  • (c) Methyl 7-nitro-2-oxo-1,3,4-trihydroquinoline-3-carboxylate. A mixture of 2-amino-4-nitrobenzaldehyde, Example 86(b), (1.66 g, 10.0 mmol), dimethyl malonate (1.37 mL, 12.0 mmol, Aldrich), copper (II) acetate (100 mg, 0.5 mmol, Aldrich) and potassium acetate (99 mg, 1.0 mmol, Bayer) in acetic acid (20 mL) was stirred at 110° C. for 48 h. Most of the solvent was removed in vacuo and the resulting precipitate was collected by filtration, washed with EtOAc and dried in vacuo to give the title product. MS (ESI, pos. ion) m/z: 248 (M+1)
    Figure US20060030618A1-20060209-C00285
  • (d) 3-(Hydroxymethyl)-7-nitro-1,3,4-trihydroquinolin-2-one and (7-nitro-3-1,2,3,4-tetrahydroquinolyl)methan-1-ol. To a solution of methyl 7-nitro-2-oxo-1,3,4-trihydroquinoline-3-carboxylate, Example 86(c), (1.23 g, 5.0 mmol) in THF (50 mL) was added LiBH4 (12.5 mL, 25.0 mmol, 2.0 M in THF, Aldrich). The reaction mixture was stirred at 40° C. for 18 h, then quenched by the careful addition of satd NH4Cl (20 mL). The mixture was stirred at room temperature for 30 min, then extracted with EtOAc (2×50 mL). The combined organic phases were washed with satd NaCl (10 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (50% EtOAc/CH2Cl2) provided 3-(hydroxymethyl)-7-nitro-1,3,4-trihydroquinolin-2-one [MS (ESI, pos. ion) m/z: 223 (M+1)] and (7-nitro-3-1,2,3,4-tetrahydroquinolyl)methan-1-ol [MS (ESI, pos. ion) m/z: 209 (M+1)].
    Figure US20060030618A1-20060209-C00286
  • (e) 7-Amino-3-(hydroxymethyl)-1,3,4-trihydroquinolin-2-one. Analogous to the procedure used to prepare Example 3, step (a), 3-(hydroxymethyl)-7-nitro-1,3,4-trihydroquinolin-2-one, Example 86(d), (66 mg, 0.30 mmol) provided, after purification by silica gel chromatography (10% MeOH/CH2Cl2), the title compound. MS (ESI, pos. ion) m/z: 193 (M+1).
  • (f) (2E)-3-[4-(tert-Butyl)phenyl]-N-[3-(hydroxymethyl)-2-oxo(7-1,3,4-trihydroquinolyl)]prop-2-enamide. Analogous to the procedure used to prepare Example 1, 4-tert-butyl-trans-cinnamic acid (67 mg, 0.33 mmol, EMKA-Chemie) and 7-amino-3-(hydroxymethyl)-1,3,4-trihydroquinolin-2-one, Example 86(e), (52 mg, 0.27 mmol) provided, after purification by silica gel chromatography (10% MeOH/EtOAc), the title compound as a pale yellow solid. MP 201-203° C. MS (ESI, pos. ion) m/z: 379 (M+1).
    • EXAMPLE 87
  • Figure US20060030618A1-20060209-C00287
    • (2E)-N-[3-(Hydroxymethyl)(7-1,2,3,4-tetrahydroquinolyl)]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00288
  • (a) (7-Amino-3-1,2,3,4-tetrahydroquinolyl)methan-1-ol. Analogous to the procedure used to prepare Example 3, step (a), (7-nitro-3-1,2,3,4-tetrahydroquinolyl)methan-1-ol, Example 86(d), (140 mg, 0.68 mmol) provided, after purification by silica gel chromatography (10% MeOH/CH2Cl2), the title compound. MS (ESI, pos. ion) m/z: 179 (M+1).
  • (b) (2E)-N-[3-(Hydroxymethyl)(7-1,2,3,4-tetrahydroquinolyl)]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide. Analogous to the procedure used to prepare Example 1, trans-4-(trifluoromethyl)cinnamic acid (120 mg, 0.55 mmol, Aldrich) and (7-amino-3-1,2,3,4-tetrahydroquinolyl)methan-1-ol, Example 87(a), (98 mg, 0.55 mmol) provided, after purification by silica gel chromatography (10% MeOH/EtOAc), the title compound as a pale yellow solid. MP 176-179° C. MS (ESI, pos. ion) m/z: 377 (M+1).
    • EXAMPLE 88
  • Figure US20060030618A1-20060209-C00289
    • (2E)-N-[3-(hydroxymethyl)-1-methyl(7-1,2,3,4-tetrahydroquinolyl)]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide
  • A mixture of (2E)-N-[3-(hydroxymethyl)(7-1,2,3,4-tetrahydroquinolyl)]-3-[4-(trifluoromethyl)phenyl]prop-2-enamide, Example 87, (75 mg, 0.20 mmol), iodomethane (0.014 mL, 0.22 mmol, Aldrich) and NaHCO3 (84 mg, 1.0 mmol) in DMF (1.0 mL, Aldrich) was stirred for 4 h at room temperature. Water (5 mL) was added and the mixture was extracted with EtOAc (2×20 mL). The combined organic phases were washed with water (5 mL), satd NaCl (5 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (60% EtOAc/CH2Cl2) provided the title product as a white solid. MP 167-169° C. MS (ESI, pos. ion) m/z: 391 (M+1).
    • EXAMPLE 89
  • Figure US20060030618A1-20060209-C00290
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-5-(1,3-dioxolan-2-yl)pent-2-enamide
  • Analogous to the procedure used to prepare Example 53(a), (1,3-dioxolan-2-ylethyl)zinc bromide (3.0 mL, 1.5 mmol, 0.5 M THF solution, Rieke) and N-(2H,3H-benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enamide, Example 55, (0.23 g, 0.50 mmol) provided, after purification by silica gel chromatography (gradient: 30%-35% EtOAc/hexane), the title product as an amorphous white solid. MS (ESI, pos. ion) m/z: 438 (M+1).
    • EXAMPLE 90
  • Figure US20060030618A1-20060209-C00291
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-4-(3-pyridyl)but-2-enamide
  • Figure US20060030618A1-20060209-C00292
  • (a). 3-(Tributylstannanylmethyl)pyridine. Analogous to the procedure of Kaiser, E. M. and Petty, J. D. Synthesis 1975, 705-706, to a 50 mL round-bottomed flask equipped with magnetic stirring was added lithium diisopropylamide (5.2 mL, 10 mmol, 2.0 M in heptane/THF/ethylbenzene, Aldrich) at 0° C. under nitrogen, followed by hexamethylphosphoramide (1.8 mL, 10 mmol, Aldrich). The mixture was stirred for 15 min, then treated with a solution of 3-picoline (1.0 mL, 10 mmol, Aldrich) in THF (4 mL) over 5 min. The reaction mixture was stirred for 30 min, then a solution of tributyltin chloride (2.8 mL, 10 mmol, Aldrich) in THF (6 mL) was added. The resulting solution was gradually warmed to room temperature and concentrated in vacuo. Purification by silica gel chromatography (gradient: 2%-5% EtOAc/hexane) provided the title product as a colorless oil. MS (ESI, pos. ion) m/z: 382 (M+1).
  • (b) (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-4-(3-pyridyl)but-2-enamide. To a 50 mL round-bottomed flask, equipped with magnetic stirring, was added 3-(tributylstannanylmethyl)pyridine, Example 90(a), (0.37 g, 0.97 mmol), N-(2H,3H-benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enamide, Example 55, (0.30 g, 0.65 mmol), 1-methyl-2-pyrrolidinone (2.5 mL, Aldrich), and tetrakis(triphenylphosphine)-palladium (0) (75 mg, 0.06 mmol, Aldrich). The reaction mixture was stirred at 110° C. overnight, then diluted with EtOAc (100 mL), washed with satd NaHCO3, water and satd NaCl. The organic phase was dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (25%-45% EtOAc/hexane) was followed by reverse phase preparative HPLC (CH3CN/H2O with 0.1% TFA). The fractions containing desired product were neutralized with NaHCO3. The mixture was extracted with CH2Cl2 and the organic phase concentrated in vacuo to provide the title product as an amorphous white solid. MS (ESI, pos. ion) m/z: 429 (M+1).
    • EXAMPLE 91
  • Figure US20060030618A1-20060209-C00293
    • N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-4-pyrrolidinylbut-2-enamide
  • Figure US20060030618A1-20060209-C00294
  • (a). Methyl (2E)-3-[4-(tert-butyl)phenyl]but-2-enoate. To a 100 m]L round-bottomed flask purged with N2 was added 1-bromo-4-tert-butylbenzene (2.34 g, 11.0 mmol, Aldrich), methyl crotonate (1.08 mL, 10 mmol, Aldrich), N-methyldicyclohexylamine (3.31 mL, 15 mmol, Aldrich), palladium acetate (0.045 g, 0.20 mmol, Aldrich), tetraethylammonium chloride (1.66 g, 10.0 mmol, Fluka), and N,N-dimethylacetamide (40 mL, Aldrich). The reaction mixture was magnetically stirred at 100° C. overnight, then allowed to cool to 25° C., diluted with Et2O, and filtered through Celite. The solution was washed with H2O (3×), dried over MgSO4, filtered, and concentrated in vacuo. Purification by silica gel chromatography (gradient: 0.5%-3% dichloromethane in hexane) provided the title product as a colorless oil. MS (ESI, pos. ion) m/z: 233 (M+1).
    Figure US20060030618A1-20060209-C00295
  • (b) Methyl (2Z)-3-[4-(tert-butyl)phenyl]-4-pyrrolidinylbut-2-enoate. A solution of methyl (2E)-3-[4-(tert-butyl)phenyl]but-2-enoate, Example 91(a), (0.37 g, 1.6 mmol) in CCl4 (15 mL), magnetically stirred in a 50 mL round-bottomed flask under N2, was treated with N-bromosuccinimide (0.31 g, 1.75 mmol, Aldrich) and 2,2′-azobisisobutyronitrile (5 mg, 0.03 mmol, Aldrich). The reaction mixture was magnetically stirred under reflux overnight, then allowed to cool to 25° C. The solid was filtered. The filtrate was concentrated in vacuo to afford a yellow oil [MS (ESI, pos. ion) m/z: 311, 313 (M+1, M+3)]. To a solution of the yellow oil in TBF (5 mL), was added pyrrolidine (0.16 mL, 1.9 mmol, Aldrich) and N,N-diisopropylethylamine (0.33 mL, 1.9 mmol, Aldrich). The reaction mixture was magnetically stirred at room temperature overnight, then concentrated in vacuo. The residue was treated with water and extracted with dichloromethane (3×). The organic phase was dried over Na2SO4, filtered and concentrated in vacuo to afford a yellow oil. Purification by silica gel chromatography (gradient: 4%-20% EtOAc/hexane) provided the title product as a pale yellow oil. MS (ESI, pos. ion) m/z: 302 (M+1).
  • (c). N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)(2Z)-3-[4-(tert-butyl)phenyl]-4-pyrrolidinylbut-2-enamide. To a 50 mL round-bottomed flask charged with methyl (2Z)-3-[4-(tert-butyl)phenyl]-4-pyrrolidinylbut-2-enoate, Example 91(b), (188 mg, 0.62 mmol) was added THF (2 mL), MeOH (0.2 mL), H2O (1 mL), and lithium hydroxide monohydrate (54 mg, 1.25 mmol, Aldrich). The reaction mixture was magnetically stirred at room temperature overnight. The excess lithium hydroxide was removed by filtration. The mixture was purified by reverse phase preparative HPLC (CH3CN/H2O with 0.1% TFA), concentrated in vacuo, then treated with an excess of HCl in Et2O. Concentration in vacuo provided a pale yellow solid 0.15 g [MS (ESI, pos. ion) m/z: 288 (M+1)]. Analogous to the procedure used to prepare Example 1, the solid (77 mg) and 1,4-benzodioxan-6-amine (61 mg, 0.40 mmol, Aldrich) provided the crude title product. Purification by silica gel chromatography (gradient: 1-5% MeOH in CH2Cl2) was followed by reverse phase preparative HPLC (CH3CN/H2O with 0.1% TFA). The fractions containing desired product were neutralized with NaHCO3. The mixture was extracted with CH2Cl2 and the organic phase concentrated in vacuo to provide the title product as a pale yellow oil. MS (ESI, pos. ion) m/z: 421 (M+1).
    • EXAMPLE 92
  • Figure US20060030618A1-20060209-C00296
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-6-imidazolylhex-2-enamide
  • Figure US20060030618A1-20060209-C00297
  • (a). Ethyl (2E)-3-[4-(tert-butyl)phenyl]-5-(1,3-dioxolan-2-yl)pent-2-enoate. Analogous to the procedure used to prepare Example 53(a), starting from (1,3-dioxolan-2-ylethyl)zinc bromide (0.5 M TBIF solution, 40 mL, 20 mmol, Rieke) and ethyl (2Z)-3-[4-(tert-butyl)phenyl]-3-iodoprop-2-enoate, Example 52(b), (3.58 g, 10.0 mmol), the title product was obtained as a colorless oil. MS (ESI, pos. ion) m/z: 333 (M+1).
    Figure US20060030618A1-20060209-C00298
  • (b). Ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-oxohex-2-enoate. To a round-bottomed flask was added ethyl (2E)-3-[4-(tert-butyl)phenyl]-5-(1,3-dioxolan-2-yl)pent-2-enoate, Example 92(a), (2.7 g, 8.1 mmol), THF (3 mL), and 5 N HCl (12 mL). The reaction mixture was initially stirred at room temperature for 24 h, then heated to 40° C. overnight. The pH was adjusted to ˜5-6 by the addition of NaHCO3 and the mixture was extracted with EtOAc. The combined organic extract was dried over Na2SO4, filtered, and concentrated in vacuo. Purification by silica gel chromatography (5% EtOAc/hexane) provided the title product as a white solid. MS (ESI, pos. ion) m/z: 289 (M+1).
    Figure US20060030618A1-20060209-C00299
  • (c). Ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-hydroxyhex-2-enoate. To solution of ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-oxohex-2-enoate, Example 92(b), (1.5 g, 5.3 mmol) in MeOH (18 mL), magnetically stirred at 0° C. in a 100 mL round-bottomed flask, was added sodium borohydride (0.40 g, 11 mmol, Aldrich). The mixture was allowed to gradually warm up to room temperature over 2 h, then quenched with water (20 mL) and extracted with EtOAc (4×). The organic extract was dried over Na2SO4, filtered, and concentrated in vacuo. Purification by silica gel chromatography (15% EtOAc/hexane) provided the title product as a colorless oil in quantitative yield. MS (PSI, pos. ion) m/z: 291 (M+1).
    Figure US20060030618A1-20060209-C00300
  • (d). Ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-iodohex-2-enoate. To a 100 mL round-bottomed flask charged with ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-hydroxyhex-2-enoate, Example 92(c), (0.80 g, 2.7 mmol) and CH2Cl2 (10 mL) at room temperature, was added triphenylphosphine (0.87 g, 3.3 mmol, Aldrich), imidazole (0.22 g, 3.3 mmol, Aldrich), and 12 (1.2 g, 4.7 mmol, Aldrich). The reaction mixture was stirred for 2 h, filtered and concentrated in vacuo. Purification by silica gel chromatography (3% EtOAc/hexane) provided the title product as a white semi-solid in quantitative yield. MS (ESI, pos. ion) m/z: 401 (M+1).
    Figure US20060030618A1-20060209-C00301
  • (e) Ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-imidazolylhex-2-enoate. To a 100 mL round-bottomed flask charged with ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-iodohex-2-enoate, Example 92(d), (1.1 g, 2.7 mmol), imidazole (0.20 g, 3.0 mmol, Aldrich), benzyltriethylammonium chloride (63 mg, 0.30 mmol, Aldrich), and CH2Cl2 (15 mL), stirred magnetically at room temperature, was added potassium hydroxide (50% aqueous solution, 1.5 mL). The reaction mixture was stirred at 50° C. overnight, then diluted with water. The reaction mixture was extracted with CH2Cl2. The organic solution was dried over Na2SO4, filtered, and concentrated in vacuo. Purification by silica gel chromatography (50% EtOAc/hexane) provided the title product as a pale yellow oil. MS (ESI, pos. ion) m/z: 341 (M+1).
    Figure US20060030618A1-20060209-C00302
  • (f) (2E)-3-[4-(tert-Butyl)phenyl]-6-imidazolylhex-2-enoic acid. To a 50 mL round-bottomed flask equipped with a reflux condenser was added ethyl (2E)-3-[4-(tert-butyl)phenyl]-6-imidazolylhex-2-enoate, Example 92(e), (0.35 g, 1.0 mmol), THF (6 mL) and KOH (50% aqueous solution, 1.5 mL). The reaction mixture was heated and magnetically stirred under reflux overnight, then concentrated in vacuo and acidified with glacial acetic acid to pH ˜4-5. The aqueous mixture was extracted with CH2Cl2 and the organic phase was dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (5%-10% MeOH/CH2Cl2) provided the title product as a white solid. MS (ESI, pos. ion) m/z: 313 (M+1).
  • (g) (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-6-imidazolylhex-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[4-(tert-butyl)phenyl]-6-imidazolylhex-2-enoic acid, Example 92(f), (76 mg, 0.24 mmol) and 1,4-benzodioxan-6-amine (36 mg, 0.24 mmol, Aldrich) provided, after purification by silica gel chromatography (3% -5% MeOHWCH2Cl2), the title product as an amorphous off-white solid. MS (ESI, pos. ion) m/z: 446 (M+1).
    • EXAMPLE 93
  • Figure US20060030618A1-20060209-C00303
  • 3-(4-tert-Butyl-phenyl)-6-imidazol-1-yl-hex-2-enoic acid benzothiazol-6-ylamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[4-(tert-butyl)phenyl]-6-imidazolylhex-2-enoic acid, Example 92(f), (76 mg, 0.24 mmol) and 6-aminobenzothiazole (36 mg, 0.24 mmol, Lancaster) provided, after purification by silica gel chromatography (3% -5% MeOH/CH2Cl2), the title compound as a white solid. MS (ESI, pos. ion) m/z: 445 (M+1).
    • EXAMPLE 94
  • Figure US20060030618A1-20060209-C00304
    • (2E)-N-(2H,3H-benzo[e]1,4-dioxan-6-yl)-3-[2-morpholin-4-yl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enamide
  • Figure US20060030618A1-20060209-C00305
  • (a) 2-Morpholin-4-yl-6-(trifluoromethyl)pyridine-3-carboxylic acid. To a round-bottomed flask was added 2-chloro-6-trifluoromethylnicotinic acid (2.0 g, 8.9 mmol, Matrix) and morpholine (5.0 g, 57 mmol, Aldrich). The reaction mixture was magnetically stirred at 25° C. for 48 h, then diluted with 1 N HCl (100 mL) and extracted with EtOAc (100 mL). The aqueous phase was saturated with NaCl and extracted again with EtOAc (50 mL). The combined EtOAc extracts were washed with 1 N HCl (50 mL), satd NaCl (50 mL), dried over MgSO4, filtered and concentrated in vacuo to afford the title product as an off-white waxy solid. MS (ESI, pos. ion) m/z: 277 (M+1).
    Figure US20060030618A1-20060209-C00306
  • (b) [2-Morpholin-4-yl-6-(trifluoromethyl)-3-pyridyl]methan-1-ol. A solution of 2-morpholin-4-yl-6-(trifluoromethyl)pyridine-3-carboxylic acid, Example 94(a), (2.1 g, 7.6 mmol) in anhydrous THF (20 mL) was treated dropwise with lithium aluminum hydride (15 mL, 15 mmol, 1.0 M in THF, Aldrich) with stirring under N2 at 25° C. The reaction mixture was stirred at 25° C. for 1.5 h, then quenched by the dropwise addition of a 10% aqueous solution of Rochelle salt (50 mL, potassium sodium tartrate, Aldrich). EtOAc (50 mL) was added and the bi-phasic mixture stirred vigorously for 2 h at 25° C. The mixture was diluted with water (100 mL) and the phases separated. The aqueous phase was extracted with EtOAc (2×75 mL), the organic phases were combined and washed with 1 N NaOH (2×75 mL), satd NaCl (75 mL), dried over MgSO4, filtered and concentrated in vacuo to afford the title product as a viscous yellow oil. MS (ESI, pos. ion) m/z: 263 (M+1).
    Figure US20060030618A1-20060209-C00307
  • (c) 2-Morpholin-4-yl-6-(trifluoromethyl)pyridine-3-carbaldehyde. A solution of oxalyl chloride (3.6 mL, 7.2 mmol, 2.0 M in CH2Cl2, Aldrich) in anhydrous CH2Cl2 (20 mL) was magnetically stirred under N2, in an oven-dried round-bottomed flask, at −60° C. The solution was treated dropwise with methyl sulfoxide (1.1 mL, 15 mmol, Aldrich) then stirred for 10 min. A solution of [2-morpholin-4-yl-6-(trifluoromethyl)-3-pyridyl]methan-1-ol, Example 94(b), (1.7 g, 6.5 mmol) in anhydrous CH2Cl2 (20 mL) was added via cannula, and the reaction mixture stirred at −60° C. for 15 min. Triethylamine (4.5 mL, 32 mmol, Aldrich) was added, the cooling bath was removed, and the reaction mixture allowed to warm to 25° C. and stirred at that temperature for 1 h. The mixture was washed with water (30 mL) and the aqueous wash was back-extracted with CH2Cl2 (2×20 mL). The combined organic phase was washed with water (30 mL), satd NaCl (30 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (9:1 hexane:EtOAc) provided the title product as a viscous yellow oil. MS (ESI, pos. ion) m/z: 261 (M+1).
    Figure US20060030618A1-20060209-C00308
  • (d) (2E)-3-[2-Morpholin-4-yl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid. Analogous to the procedure described for Example 40, step (a), 2-morpholin-4-yl-6-(trifluoromethyl)pyridine-3-carbaldehyde, Example 94(c), (1.2 g, 4.6 mmol) provided the title product as a yellow solid. MS (ESI, pos. ion) m/z: 303 (M+1).
  • (e) (2E)-N-(2H,3H-benzo[e]1,4-dioxan-6-yl)-3-[2-morpholin-4-yl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enamide. (2E)-3-[2-Morpholin-4-yl-6-(trifluoromethyl)(3-pyridyl)]prop-2-enoic acid, Example 94(d), (200 mg, 0.66 mmol) was dissolved in anhydrous CH2Cl2 (10 mL) and treated with oxalyl chloride (0.36 mL, 0.72 mmol, 2.0 M in CH2Cl2, Aldrich) and anhydrous DMF (2 uL). The reaction mixture was stirred at reflux for 30 min, then concentrated in vacuo. The residue was dissolved in anhydrous CH2Cl2 (10 mL), treated with pyridine (0.27 mL, 3.5 mmol, Aldrich) and 1,4-benzodioxan-6-amine (120 mg, 0.79 mmol, Aldrich) and stirred at reflux for 15 min. The reaction mixture was concentrated in vacuo and the residue dissolved in EtOAc (75 mL). The mixture was washed with 1 N HCl (2×50 mL), 1 N NaOH (50 mL), water (50 mL), satd NaCl (50 mL), dried over MgSO4, filtered and concentrated in vacuo. Recrystallization from EtOAc and hexane provided the title product as pale tan crystals. MP 200-201° C. MS (ESI, pos. ion) m/z: 436 (M+1).
    • EXAMPLE 95
  • Figure US20060030618A1-20060209-C00309
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)-2-bromophenyl]prop-2-enamide
  • Figure US20060030618A1-20060209-C00310
  • (a) 4-(tert-Butyl)-2-bromo-1-(bromomethyl)benzene. According to the procedure of Kikuchi, D. et al, J. Org. Chem. 1998, 63, 6023-6026, to a solution of sodium bromate (22 g, 145 mmol, Aldrich) in water (75 mL), magnetically stirred in an Erlenmeyer flask at 25° C., was added a solution of 4-t-butyltoluene (5.0 mL, 29 mmol, Aldrich) in acetonitrile (60 mL). The bi-phasic mixture was vigorously stirred while a solution of sodium bisulfite (15 g, 145 mmol, Baker) in water (150 mL) was added dropwise, via addition funnel, over 20 min. The reaction mixture was stirred for 6 h, then extracted with Et2O (300 mL). The organic phase was washed with satd aq. Na2S2O3 (2×100 mL), satd NaCl (50 mL), dried over MgSO4, filtered and concentrated in vacuo to afford of the title product as a pale orange oil.
    Figure US20060030618A1-20060209-C00311
  • (b) 4-(tert-Butyl)-2-bromobenzaldehyde. According to the procedure of Mallory, et al, Tetrahedron 2001, 57, 3715-3724, a solution of sodium ethoxide (12 mL, 32 mmol, 21% in EtOH, Aldrich) in absolute EtOH (100 mL) was magnetically stirred under N2 at 25° C. and treated with 2-nitropropane (2.9 mL, 32 mmol, Aldrich) followed by 4-(tert-butyl)-2-bromo-1-(bromomethyl)benzene, Example 95(a), (9.0 g, 29 mmol). The reaction mixture was stirred at 25° C. for 5 h, then concentrated in vacuo to an orange solid. The solid was partitioned between Et2O (150 mL) and water (100 mL). The layers were separated and the organic phase was washed with water (100 mL), 1 N NaOH (2×75 mL), satd NaCl (50 mL), dried over MgSO4, filtered and concentrated in vacuo to afford the title product as an orange oil.
    Figure US20060030618A1-20060209-C00312
  • (c) (2E)-3-[4-(tert-Butyl)-2-bromophenyl]prop-2-enoic acid. Analogous to the procedure described for Example 40, step (a), 4-(tert-butyl)-2-bromobenzaldehyde, Example 95(b), (6.5 g, 27 mmol) provided the title product as a white solid. MS (ESI, pos. ion) m/z: 283, 285 (M, M+2).
  • (d) (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)-2-bromophenyl]prop-2-enamide. Analogous to the procedure described for Example 94, step (e), (2E)-3-[4-(tert-butyl)-2-bromophenyl]prop-2-enoic acid, Example 95(c), (3.0 g, 11 mmol) and 1,4-benzodioxan-6-amine (1.9 g, 13 mmol, Aldrich) provided, after recrystallization from CH2Cl2 and hexane, the title product as off-white crystals. MP 206-210° C. MS (ESI, pos. ion) m/z: 416, 418 (M, M+2).
    • EXAMPLE 96
  • Figure US20060030618A1-20060209-C00313
    • Ethyl 2-[(1E)-2-(N-(2H,3H-benzo[e]1,4-dioxan-6-yl)carbamoyl)vinyl]-5-(tert-butyl)benzoate
  • According to the procedure of Ma, et al, J. Org. Chem. 1999, 64, 120-125, a solution of (2E)-N-(2H,3H-benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)-2-bromophenyl]prop-2-enamide, Example 95, (200 mg, 0.48 mmol) in anhydrous EtOH (5 mL) and methyl sulfoxide (5 mL) was treated with triethylamine (0.67 mL, 0.48 mmol, Aldrich) and 1,3-bis(diphenylphosphino)propane (50 mg, 0.12 mmol, Aldrich). The mixture was purged with a stream of carbon monoxide, then treated with palladium acetate (22 mg, 0.10 mmol, Aldrich), and stirred under a balloon of carbon monoxide in a 70° C. oil bath for 3 h. The reaction mixture was allowed to cool to 25° C. and partitioned between EtOAc (50 mL) and water (20 mL). The organic phase was washed with water (10 mL), satd NaCl (10 mL), dried over MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (step gradient, 4:1 then 3:1, hexane:EtOAc), followed by recrystallization from EtOAc and hexane, provided the title product as white crystals. MP 155° C. MS (ESI, pos. ion) m/z: 410 (M+1).
    • EXAMPLE 97
  • Figure US20060030618A1-20060209-C00314
    • (2E)-3-[2-Bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide
  • Figure US20060030618A1-20060209-C00315
  • (a) 2-Bromo-4-(trifluoromethyl)benzoic acid. To a solution of 2-bromo-1-methyl-4-trifluoromethylbenzene (7.6 g, 32 mmol, ABCR) in pyridine (75 mL) was added tetraethylammonium permanganate (24 g, 96 mmol, prepared according to the procedure of Sala, et al. J. Chem. Soc., Chem. Comm. 1978, 253). The reaction mixture was warmed to 70° C. and stirred at that temperature for 30 h. The reaction mixture was allowed to cool to 25° C. and poured into an ice bath containing cond HCl (150 mL) and NaHSO3 (150 g). The mixture turned to a clear aqueous solution and was extracted with EtOAc (4×200 mL). The combined extracts were washed with satd NaCl (200 mL), dried over Na2SO4, filtered and concentrated in vacuo to provide the title product as a white solid. MS (ESI, neg. ion) m/z: 267 (M−1).
    Figure US20060030618A1-20060209-C00316
  • (b) [2-Bromo-4-(trifluoromethyl)phenyl]methan-1-ol. Analogous to the procedure used to prepare Example 46, step (a), 2-bromo-4-(trifluoromethyl)benzoic acid, Example 97(a), (5.4 g, 20 mmol) provided, after purificaton by silica gel chromatography (gradient: 0-10% EtOAc in hexane), the title product as a white solid. MS (ESI, neg. ion) m/z: 313 (M+acetate).
    Figure US20060030618A1-20060209-C00317
  • (c) 2-Bromo-4-(trifluoromethyl)benzaldehyde. Analogous to the procedure used to prepare Example 46, step (b), [2-bromo-4-(trifluoromethyl)phenyl]methan-1-ol, Example 97(b), (4.6 g, 18 mmol) provided, after purificaton by silica gel chromatography (gradient: 0-4% EtOAc in hexane), the title product as a colorless oil.
    Figure US20060030618A1-20060209-C00318
  • (d) Methyl (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoate. Analogous to the procedure used to prepare Example 46, step (c), 2-bromo-4-(trifluoromethyl)benzaldehyde, Example 97(c), (2.3 g, 8.9 mmol) and carbomethoxymethylene triphenylphosphorane (4.2 g, 12.5 mmol, Aldrich) provided, after purificaton by silica gel chromatography (gradient: 0-3% EtOAc in hexane), the title product as a white solid.
    Figure US20060030618A1-20060209-C00319
  • (e) (2E)-3-[2-Bromo-4-(trifluoromethyl)phenyl]prop-2-enoic acid. Analogous to the procedure used to prepare Example 46, step (d), methyl (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoate, Example 97(d), (2.25 g, 8.9 mmol) provided the title product.
  • (f) (2E)-3-[2-Bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 97(e), (140 mg, 0.48 mmol) and 5-aminoindole (75 mg, 0.57 mmol, Aldrich) provided, after purification by silica gel chromatography (gradient: 0-25% EtOAc in hexane), the title compound as a yellow solid. MP 205-207° C. MS (ESI, pos. ion) m/z: 409 (M+1).
    • EXAMPLE 98
  • Figure US20060030618A1-20060209-C00320
    • (2E)-N-Benzothiazol-6-yl-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 97(e), (140 mg, 0.47 mmol) and 6-aminobenzothiazole (86 mg, 0.57 mmol, Lancaster) provided, after purification by silica gel chromatography (gradient: 0-30% EtOAc in hexane), the title product as an off-white solid. MP 214-215° C. MS (ESI, pos. ion) m/z: 427 (M+1).
    • EXAMPLE 99
  • Figure US20060030618A1-20060209-C00321
    • (2E)-N-(2H,3H-Benzo[e]1,4-dioxan-6-yl)-3-[2-bromo-4-(trifluoromethyl)-phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 97(e), (140 mg, 0.47 mmol) and 1,4-benzodioxan-6-amine (86 mg, 0.57 mmol, Aldrich) provided, after purification by silica gel chromatography (gradient: 0-18% EtOAc in hexane), the title product as an off-white solid. MP 212-213° C. MS (ESI, pos. ion) m/z: 428 (M+1).
    • EXAMPLE 100
  • Figure US20060030618A1-20060209-C00322
    • (2E)-N-indol-5-yl-3-[2-(6-methoxy(3-pyridyl))-4-(trifluoromethyl)phenyl]-prop-2-enamide
  • A mixture of (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 97, (100 mg, 0.24 mmol), 2-methoxy-5-pyridineboronic acid (60 mg, 0.39 mmol, Digital Specialty Chemicals), tris(dibenzylideneacetone)-dipalladium(0) (22 mg, 0.024 mmol, Aldrich) and triphenylphosphine (26 mg, 0.098 mmol, Aldrich) in toluene (1.2 mL), 2.0M aqueous Na2CO3 (0.4 mL) and ethanol (0.4 mL) was stirred at 120° C. overnight. The reaction mixture was filtered through a pad of Celite and diluted with water (50 mL). The aqueous phase was extracted with EtOAc (3×60 mL). The combined extracts were washed with satd NaCl (100 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (gradient: 0-20% EtOAc in hexane) provided the title product as a yellow solid. MP 219-221° C. MS (ESI, pos. ion) m/z: 438 (M+1).
    • EXAMPLE 101
  • Figure US20060030618A1-20060209-C00323
    • (2E)-N-Indol-5-yl-3-[2-(4-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 100, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 97, (120 mg, 0.29 mmol) and pyridine-4-boronic acid (72 mg, 0.59 mmol, Frontier Scientific) provided, after purification by silica gel chromatography (gradient: 0-60% EtOAc in hexane), the title product as a yellow solid. MP 229-234° C. MS (ESI, pos. ion) m/z: 408 (M+1).
    • EXAMPLE 102
  • Figure US20060030618A1-20060209-C00324
    • (2E)-N-Indol-5-yl-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 100, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 97, (120 mg, 0.29 mmol) and pyridine-3-boronic acid (58 mg, 0.47 mmol, Frontier Scientific) provided, after purification by silica gel chromatography (gradient: 0-20% EtOAc in hexane), the title product as a yellow solid. MP 196-197° C. MS (ESI, pos. ion) m/z: 408 (M+1).
    • EXAMPLE 103
  • Figure US20060030618A1-20060209-C00325
    • tert-Butyl 4-{2-[(1E)-2-(N-indol-5-ylcarbamoyl)vinyl]-5-(trifluoromethyl)phenyl}-1,2,5,6-tetrahydropyridinecarboxylate
  • Analogous to the procedure used to prepare Example 100, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 97, (100 mg, 0.24 mmol) and 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (130 mg, 0.42 mmol, prepared according to the procedures of Wustrow, D. J. et al, Synthesis 1991, 993 and Ishiyama, T. et al, J. Org. Chem. 1995, 60, 7508) provided, after purification by silica gel chromatography (gradient: 0-35% EtOAc in hexane), the title product as an amorphous yellow solid. MS (ESI, pos. ion) m/z: 512 (M+1).
    • EXAMPLE 104
  • Figure US20060030618A1-20060209-C00326
    • (2E)-N-Indol-5-yl-3-[2-(1,3-thiazol-2-yl)-4-(trifluoromethyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 100, (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 97, (100 mg, 0.24 mmol) and 2-tributylstannylthiazole (155 mg, 0.42 mmol, Frontier Scientific) provided, after purification by silica gel chromatography (gradient: 0-35% EtOAc in hexane), the title product as an orange solid. MP 203-204° C. MS (ESI, pos. ion) m/z: 414 (M+1).
    • EXAMPLE 105
  • Figure US20060030618A1-20060209-C00327
    • (2E)-N-Indol-5-yl-3-[2-(3-pyridylmethyl)-4-(trifluoromethyl)phenyl]prop-2-enamide
  • A mixture of (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]-N-indol-5-ylprop-2-enamide, Example 97, (110 mg, 0.27 mmol), 3-(tributylstannanylmethyl)pyridine, Example 90(a), (160 mg, 0.43 mmol), tris(dibenzylideneacetone)dipalladium(0) (24 mg, 0.027 mmol, Aldrich) and triphenylphosphine (28 mg, 0.11 mmol, Aldrich) in 1-methyl-2-pyrrolidinone (1.5 mL) was stirred at 100° C. overnight. The reaction mixture was filtered through a pad of Celite and diluted with water (50 mL). The aqueous phase was extracted with EtOAc (3×60 mL). The combined organic extracts were washed with satd NaCl (100 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (gradient: 0-70% EtOAc in hexane) provided the title compound as an orange solid. MP 202-203° C. MS (ESI, neg. ion) m/z: 420 (M−1).
    • EXAMPLE 106
  • Figure US20060030618A1-20060209-C00328
    • (2E)-3-[2-(3-Pyridyl)-4-(trifluoromethyl)phenyl]-N-(7-quinolyl)prop-2-enamide
  • Figure US20060030618A1-20060209-C00329
  • (a) Methyl (2E)-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enoate. A mixture of methyl (2E)-3-[2-bromo-4-(trifluoromethyl)phenyl]prop-2-enoate, Example 97(d), (585 mg, 1.89 mmol), pyridine-3-boronic acid (950 mg, 2.8 mmol, Frontier Scientific), tris(dibenzylideneacetone)dipalladium (0) (170 mg, 0.19 mmol, Aldrich) and triphenylphosphine (200 mg, 0.76 mmol, Aldrich) in toluene (5 mL), 1.0 M aqueous Na2CO3 (2 mL) and ethanol (2 mL) was stirred at 80° C. under N2 overnight. The reaction mixture was filtered through a pad of Celite and diluted with water (60 mL). The aqueous phase was extracted with EtOAc (3×60 mL). The combined organic extracts were washed with satd NaCl (100 mL), dried over Na2SO4, filtered and concentrated in vacuo. Purification by silica gel chromatography (gradient: 0-35% EtOAc in hexane) provided the title product as a yellow solid. MS (ESI, pos. ion) m/z: 308 (M+1).
    Figure US20060030618A1-20060209-C00330
  • (b) (2E)-3-[2-(3-Pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enoic acid. A mixture of methyl (2E)-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enoate, Example 106(a), (540 mg, 1.8 mmol) and LiOH monohydrate (370 mg, 8.8 mmol) in wet ethanol (5 mL) was stirred at room temperature overnight. The reaction mixture was neutralized with aqueous HCl (2.0 M, 4.4 mL, 8.8 mmol) and concentrated under reduced pressure. The material was dried under vacuum at 60° C. for 4 h to provide 955 mg of the crude material, which contained LiCl as a byproduct. MS (ESI, pos. ion) m/z: 294 (M+1).
  • (c) (2E)-3-[2-(3-Pyridyl)-4-(trifluoromethyl)phenyl]-N-(7-quinolyl)prop-2-enamide. Analogous to the procedure used to prepare Example 1, (2E)-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 106(b), (185 mg) and 7-aminoquinoline (64 mg, 0.44 mmol, Specs) provided, after purification by silica gel chromatography (gradient: 0-75% EtOAc in hexane), the title compound as an amorphous off-white solid. MS (ESI, pos. ion) m/z: 420 (M+1).
    • EXAMPLE 107
  • Figure US20060030618A1-20060209-C00331
    • (2E)-3-[2-(3-Pyridyl)-4-(trifluoromethyl)phenyl]-N-(3-quinolyl)prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 106(b), (185 mg) and 3-aminoquinoline (64 mg, 0.44 mmol, Aldrich) provided, after purification by silica gel chromatography (gradient: 0-45% EtOAc in hexane), the title compound as a white solid. MP 196-199° C. MS (ESI, pos. ion) m/z: 420 (M+1).
    • EXAMPLE 108
  • Figure US20060030618A1-20060209-C00332
    • (2E)-N-Indol-6-yl-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enamide
  • Analogous to the procedure used to prepare Example 1, (2E)-3-[2-(3-pyridyl)-4-(trifluoromethyl)phenyl]prop-2-enoic acid, Example 106(b), (185 mg) and 6-aminoindole (59 mg, 0.44 mmol, Aldrich) provided, after purification by silica gel chromatography (gradient: 0-50% EtOAc in hexane), the title compound as an amorphous orange solid. MS (ESI, pos. ion) m/z: 408 (M+1).
    • EXAMPLE 109
  • Figure US20060030618A1-20060209-C00333
    • N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]propanamide
  • Figure US20060030618A1-20060209-C00334
  • (a) (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]-prop-2-enamide. A solution of 4-t-butyl-trans-cinnamic acid (500 mg, 2.45 mmol, EMKA-Chemie) in anhydrous CH2Cl2 (10 mL) was-magnetically stirred and treated with oxalyl chloride (0.22 mL, 2.5 mmol, Aldrich) and DMF (0.005 mL). The reaction mixture was stirred at reflux for 30 min, then concentrated in vacuo. The residue was dissolved in acetone (1 mL) and added to a mixture of 1,4-benzodioxan-6-amine (370 mg, 2.45 mmol, Aldrich) and K2CO3 (500 mg) in acetone (2 mL) and water (4 mL), stirred at 0° C. The reaction mixture was vigorously stirred at 0° C. for 30 min, then diluted with ice water (50 mL). The resulting solid precipitate was collected by filtration and dissolved in CH2Cl2 (20 mL) and Et2O (150 mL). The organic solution was washed with 1 N HCl (3×75 mL), satd NaCl (50 mL), dried over MgSO4, filtered and concentrated to afford the title product as an off-white foam. MS (ESI, pos. ion) m/z: 338 (M+1).
  • (b) N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]propanamide. (2E)-N-(2H,3H-Benzo[3,4-e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)phenyl]prop-2-enamide, Example 109(a), (200 mg, 0.59 mmol) was dissolved in EtOH (25 mL), purged with N2, treated with 10% Pd on carbon (50 mg, Aldrich) then purged with H2 and the suspension stirred at 25° C., under 1 atm H2, for 16 hr. The suspension was purged with N2, filtered through a pad of Celite, and concentrated in vacuo to a white foam. Purification by silica gel chromatography (45:45: 10 hexane:CH2Cl2:EtOAc) provided the title product as a clear glass. MS (ESI, pos. ion) m/z: 340 (M+1).
    Figure US20060030618A1-20060209-C00335
    Figure US20060030618A1-20060209-C00336
    • (a) 4-[4-(tert-Butyl)phenyl]pyridine
  • To 4-bromopyridine hydrochloride (Aldrich) (8.9 g, 46 mmol) and tetrakis(triphenylphosphine)palladium(0) (Aldrich) (1.6 g, 1.4 mmol) was added 1,2-dimethoxyethane (250 mL) with stirring under nitrogen. After 20 min, a solution of Na2CO3 (9.7 g in 70 mL of water) and 4-tert-butylbenzeneboronic acid (9.8 g, 55 mmol) were added sequentially to the mixture. The reaction was stirred at reflux overnight. The reaction mixture was concentrated in vacuo to approximately ⅓ its original volume, and the mixture was extracted with EtOAc (2×100 mL). The combined EtOAc layers were washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by silica gel chromatography (1:5 EtOAc/hexanes) gave the title compound as a white solid. MS (ESI, pos. ion) m/z: 212 (M+1).
    Figure US20060030618A1-20060209-C00337
    • (b) 4-[4-(tert-Butyl)phenyl]pyridine 1-oxide
  • To the mixture of 4-[4-(tert-butyl)phenyl]pyridine (8.7 g, 41 mmol) and methyltrioxorhenium (VII) (Aldrich) (170 mg, 0.7 mmol) in a 100-mL round-bottomed flask was added CH2Cl2 (18 mL). The mixture was then treated with 12 mL of hydrogen peroxide (Aldrich) dropwise. The reaction was stirred at room temperature under nitrogen overnight. Methylene chloride and brine were then added, and the aqueous layer was extracted with CH2Cl2 (40 mL). The organic layer was dried over Na2SO4, concentrated in vacuo to give the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 228 (M+1).
    Figure US20060030618A1-20060209-C00338
    • (c) 4-[4-(tert-Butyl)phenyl]-2-bromopyridine
  • To triphenylphosphine (Aldrich) (2.4 g, 9.1 mmol) dissolved in 10 mL of CH2Cl2 in a 50-mL round-bottomed flask was added bromine (Aldrich) (0.43 mL, 8.5 mmol). After stirring at 0° C. for 10 min, 4-[4-(tert-butyl)phenyl]pyridine 1-oxide (1.5 g, 6.5 mmol) was added dropwise, followed by Et3N (1.2 mL, 8.5 mmol). The reaction mixture was stirred at 0° C. for 1 h and then at room temperature overnight. Methylene chloride and brine were added, and the aqueous layer was extracted with CH2Cl2. The organic layer was collected and dried over Na2SO4, filtered and concentrated in vacuo. Following purification by silica gel chromatography (10:1 hexane:EtOAc), the title compound was obtained as a pale yellow oil. MS (ESI, pos. ion) m/z: 293 (M+1).
    Figure US20060030618A1-20060209-C00339
    • (d) 2H,3H-Benzo[e]1,4-dioxan-6-yl{4-[4-(tert-butyl)phenyl](2-pyridyl)}amine
  • To an oven-dried 50-mL round-bottomed flask were added 4-[4-(tert-butyl)phenyl]-2-bromopyridine (180 mg, 0.63 mmol) and 1,4-benzodioxan-6-amine (Aldrich) (191 mg, 1.3 mmol), followed by anhydrous toluene (60 mL) and DMF (6 mL). Nitrogen was bubbled through the above solution via a needle for 1 h. Then palladium acetate (Aldrich) (21 mg, 0.01 mmol) and BINAP (Aldrich) (59 mg, 0.01 mmol) were introduced to the reaction followed by sodium tert-butoxide (Aldrich) (170 mg, 1.8 mmol). The reaction mixture was heated in a 90 C oil bath overnight. After cooling to room temperature, the reaction mixture was dissolved in ether, washed with brine, dried over Na2SO4 and concentrated in vacuo. Following purification by silica gel chromatography (3:1 hexane:EtOAc), the title compound was obtained as a pale tan solid. MS (ESI, pos. ion) m/z: 361 (M+1) MP: 162-163° C.
    TABLE A
    The following compounds were prepared according to General Schemes I and II:
    MS (ESI, Melting
    Example Structure pos. ion) m/z Point ° C.
    111
    Figure US20060030618A1-20060209-C00340
         		303 (M + 1) 157
    112
    Figure US20060030618A1-20060209-C00341
         		333 (M + 1) amorphous
    113
    Figure US20060030618A1-20060209-C00342
         		347 (M + 1) 156
    114
    Figure US20060030618A1-20060209-C00343
         		331 (M + 1) 133
    115
    Figure US20060030618A1-20060209-C00344
         		393 (M + 1) amorphous
    116
    Figure US20060030618A1-20060209-C00345
         		342 (M + 1) 106
    117
    Figure US20060030618A1-20060209-C00346
         		360 (M + 1) 154
    118
    Figure US20060030618A1-20060209-C00347
         		354 (M + 1) 214
    119
    Figure US20060030618A1-20060209-C00348
         		372 (M + 1) 203
    120
    Figure US20060030618A1-20060209-C00349
         		366 (M + 1) 206
    121
    Figure US20060030618A1-20060209-C00350
         		373 (M + 1) 114
    122
    Figure US20060030618A1-20060209-C00351
         		383, 385 (M, M + 2) 124
    123
    Figure US20060030618A1-20060209-C00352
         		354 (M + 1) ?
    • EXAMPLE 124
  • Figure US20060030618A1-20060209-C00353
    • (a) N2-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-pyridine-2,4-diamine
  • In a 5-mL vial was added 4-amino-2-chloropyridine (Aldrich Chemical Company) (1.1 g, 8.7 mmol), 1,4-benzodioxane-6-amine (Aldrich Chemical Company) (5.3 g, 35 mmol) and copper (I) iodide (Aldrich Chemical Company) (0.17 g, 0.87 mmol). The content was sonicated at room temperature for 5 min and then heated in the Smith Microwave Synthesizer at 200° C. for 10 min. The residue was purified by flash chromatography (95:5 dichloromethane:2N NH3 in MeOH) to give the title compound as a dark solid. MS (ESI, pos. ion) m/z: 244 (M+1).
    Figure US20060030618A1-20060209-C00354
    • (b) (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine
  • Isopentyl nitrile (Aldrich Chemical Company) (3.9 mL, 29 mmol) was added to a mixture of N2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-pyridine-2,4-diamine (Example 2(a), 2.4 g, 9.8 mmol), potassium iodide (Aldrich Chemical Company) (1.6 g, 9.8 mmol), iodine (Aldrich Chemical Company) (1.2 g, 4.9 mmol) and copper (I) iodide (Aldrich Chemical Company) (1.9 g, 9.8 mmol) in 1,2-dimethoxyethane (60 mL). The reaction mixture was heated at 60-65° C. for 1 hr. After cooling to room temperature, the insoluble materials were removed by filtration and the filtrate was diluted with EtOAc, washed with 25% aqueous NH4OH, 5% aqueous sodium bisulfite and then brine. The organic layer was separated, dried over Na2SO4 and concentrated in vacuo. The residue was purified on a Biotage 40 M column (2.5:1 hexane:EtOAc) to give the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 355 (M+1).
    Figure US20060030618A1-20060209-C00355
    • (c) (4-Benzo[1,3]dioxol-5-yl-pyridin-2-yl)-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-amine
  • In a 5 mL vial were added (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 2(b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol) and 1,2-dimethoxyethane (2 mL). After stirring under nitrogen for 10 min, aqueous Na2CO3 (22 mg in 0.5 mL of water) and 3,4-(methylenedioxy)phenylboronic acid (Aldrich Chemical Company) (42 mg, 0.25 mmol) were introduced. The reaction was heated in the Smith Microwave Synthesizer at 150° C. for 10 min. The residue was partitioned between EtOAc and brine. The aqueous layer was extracted with EtOAc and the combined EtOAc layer was washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification on a Biotage 40 S column (4:1 hexane:EtOAc) gave the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 349 (M+1). Mp: 116.0-118.0° C.
    • EXAMPLE 125
  • Figure US20060030618A1-20060209-C00356
    • (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-dimethylamino-phenyl)-pyridin-2-yl]-amine
  • Following the same procedure described for Example 401(c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401(b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol), N,N-dimethylaminobenzeneboronic acid (Aldrich Chemical Company) (41 mg, 0.25 mmol) and 1,2-dimethoxyethane (2 mL) gave, after heated in the Microwave Smith Synthesizer at 150° C. for 10 min and purification on a Biotage 40S column (1.5:1 hexane:EtOAc), the title compound as a tan solid. MS (ESI, pos. ion) m/z: 348 (M+1). Mp: 154.0-155.5° C.
    • EXAMPLE 126
  • Figure US20060030618A1-20060209-C00357
    • (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-fluoro-phenyl)-pyridin-2-yl]-amine
  • Following the same procedure described for Example 401 (c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401 (b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol), 4-fluorobenzeneboronic acid (Avocado Chemical Company) (35 mg, 0.25 mmol) and 1,2-dimethoxyethane (2 mL) gave, after heated in the Microwave Smith Synthesizer at 150° C. for 10 min and purification on a Biotage 40S column (3:1 hexane:EtOAc), the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 323 (M+1). Mp: 134.5-135.0° C.
    • EXAMPLE 127
  • Figure US20060030618A1-20060209-C00358
    • (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(3-trifluoromethyl-phenyl)-pyridin-2-yl]-amine
  • Following the same procedure described for Example 401(c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401 (b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol), 3-(trifluoromethyl)phenylboronic acid (Aldrich Chemical Company) (47 mg, 0.25 mmol) and 1,2-dimethoxyethane (2 mL) gave, after heated in the Microwave Smith Synthesizer at 150° C. for 10 min and purification on a Biotage 40S column (4:1 hexane:EtOAc), the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 373 (M+1). Mp: 138.9-140.5° C.
    • EXAMPLE 128
  • Figure US20060030618A1-20060209-C00359
    • (4-Benzo[b]thiophen-2-yl-pyridin-2-yl)-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-amine
  • Following the same procedure described for Example 401(c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401(b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol), benzothiophene-2-boronic acid (Frontier Scientific, Inc.) (45 mg, 0.25 mmol) and 1,2-dimethoxyethane (2 mL) gave, after heated in the Microwave Smith Synthesizer at 150° C. for 10 min and purification on a Biotage 40S column (4:1 hexane:EtOAc), the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 361 (M+1). Mp: 154.0-154.1° C.
    • EXAMPLE 129
  • Figure US20060030618A1-20060209-C00360
    • 1-{4-[2-(2,3-Dihydro-benzo[1,4]dioxin-6-ylamino)-pyridin-4-yl]-phenyl}-ethanone
  • Following the similar procedure described for Example 401(c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401 (b), 0.73 g, 2.1 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (0.12 g, 0.11 mmol), 4-actylphenylboronic acid (Aldrich Chemical Company) (0.41 g, 2.5 mmol) and 1,2-dimethoxyethane (20 mL) gave, after heated at 90° C. overnight and purification on a Biotage 40M column (3:1 hexane:EtOAc), the title compound as a light-orange solid. MS (ESI, pos. ion) m/z: 347 (M+1). Mp: 178.0-180.5° C.
    • EXAMPLE 130
  • Figure US20060030618A1-20060209-C00361
    • 1-14-[2-(2,3-Dihydro-benzo[1,4]dioxin-6-ylamino)-pyridin-4-yl]-phenyl]-ethanol
  • To the suspension of 1-{4-[2-(2,3-dihydro-benzo[1,4]dioxin-6-ylamino)-pyridin-4-yl]-phenyl}-ethanone (Example 7, 0.19 g, 0.55 mmol) in 2 mL of MeOH was added a solution of methylamine in MeOH (Aldrich Chemical Company) (2N, 0.55 mL, 1.1 mmol). The reaction was stirred at room temperature under nitrogen overnight. NaBH4 (Aldrich Chemical Company) (25 mg, 0.66 mmol) was then added to the reaction and it was stirred for another 5 hrs. The solvent was evaporated the residue was purified on a Biotage 40M column (97:3 dichloromethane:2N NH3 in MeOH) to give the title compound as an off-white foam. MS (ESI, pos. ion) m/z: 349 (M+1). Mp: 55.9-61.5° C.
    • EXAMPLE 131
  • Figure US20060030618A1-20060209-C00362
    • [4-(3,5-Bis-trifluoromethyl-phenyl)-pyridin-2-yl]-(2,3-dihydro-benzo[1,4]-dioxin-6-yl) -amine
  • Following the same procedure described for Example 401 (c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401 (b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol), 3,5-bis(trifluoromethyl)phenylboronic acid (Aldrich Chemical Company) (64 mg, 0.25 mmol) and 1,2-dimethoxyethane (2 mL) gave, after heated in the Microwave Smith Synthesizer at 150° C. for 10 min and purification on a Biotage 40S column (4:1 hexane:EtOAc), the title compound as a light-yellow solid. MS (ESI, pos. ion) m/z: 441 (M+1). Mp: 130.0-131.5° C.
    • EXAMPLE 132
  • Figure US20060030618A1-20060209-C00363
    • (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-[4-(4-trifluoromethoxy-phenyl)-pyridin-2-yl]-amine
  • Following the same procedure described for Example 401 (c), the mixture of (2,3-dihydro-benzo[1,4]dioxin-6-yl)-(4-iodo-pyridin-2-yl)-amine (Example 401 (b), 75 mg, 0.2 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich Chemical Company) (12 mg, 0.011 mmol), 4-(trifluoromethoxy)phenylboronic acid (Lancaster Synthesis Ltd.) (51 mg, 0.25 mmol) and 1,2-dimethoxyethane (2 mL) gave, after heated in the Microwave Smith Synthesizer at 150° C. for 10 min and purification on a Biotage 40S column (4:1 hexane:EtOAc), the title compound as an orange glass. MS (ESI, pos. ion) m/z: 389 (M+1).
    • EXAMPLE 133
  • Figure US20060030618A1-20060209-C00364
    • (a) 4-(4-Trifluoromethyl-phenyl)-pyridine
  • In a 250-mL, round-bottomed flask were added 4-bromopyridine hydrochloride (Aldrich) (4.7 g, 24 mmol), tetrakis(triphenylphosphine)palladium(0) (Aldrich) (1.4 g, 1.2 mmol) and 1,2-dimethoxyethane (120 mL). After stirring under nitrogen for 10 min, a solution of Na2CO3 (5.2 g in 30 mL of water) and 4-trifluoromethylbenzeneboronic acid (5.1 g, 27 mmol) were added sequentially to the mixture. The reaction was stirred in a 90° C. oil bath overnight. The 1,2-dimethoxyethane was evaporated in vacuo, and EtOAc was added to the residue. The aqueous layer was separated and extracted with EtOAc (2×50 mL). The combined EtOAc extracts were washed with brine, dried over Na2SO4 and concentrated in vacuo. Purification by silica gel flash chromatography using 1:5 EtOAc/hexanes as eluent gave the title compound as a light-tan solid. MS (ESI, pos. ion) m/z: 224 (M+1).
    Figure US20060030618A1-20060209-C00365
    • (b) 4-(4-Trifluoromethyl-phenyl)-pyridine 1-oxide
  • To a mixture of 4-(4-trifluoromethyl-phenyl)-pyridine (5.0 g, 22 mmol) and methyltrioxorhenium (VII) (Aldrich) (110 mg, 0.45 mmol) in a 100-mL, round-bottomed flask was added CH2Cl2 (10 mL). Hydrogen peroxide (5 mL, Aldrich) was added drop-wise, and the reaction was stirred at room temperature under N2 for 48 h. The mixture was partitioned between CH2Cl2 and brine, and the aqueous layer was extracted with CH2Cl2 (40 mL). The combined organic layers were dried over Na2SO4, filtered, and concentrated in vacuo to give the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 240 (M+1).
    Figure US20060030618A1-20060209-C00366
    • (c) 2-Chloro-4-(4-trifluoromethyl-phenyl)-pyridine
  • To 4-(4-trifluoromethyl-phenyl)-pyridine 1-oxide (2.4 g, 10 mmol) was added phosphorous oxychloride (12 mL) at room temperature. The reaction mixture was heated at reflux for 5 h. POCl3 was removed under reduced pressure, and the residue was partitioned between EtOAc and aqueous ammonium hydroxide. The aqueous layer was extracted with EtOAc and the combined organic layers were dried over Na2SO4, filtered, and concentrated in vacuo. The crude material was purified by chromatography on a Biotage 40 M column (8:1 hexanes:EtOAc) to give the title compound as a white solid. MS (ESI, pos. ion) m/z: 258.5 (M+1).
    Figure US20060030618A1-20060209-C00367
    • (d) Quinolin-3-yl-[4-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-amine
  • To an oven-dried 50 mL round-bottomed flask were added 2-chloro-4-(4-trifluoromethyl-phenyl)-pyridine (138 mg, 0.54 mmol) and 3-aminoquinoline (Aldrich Chemical Company) (93 mg, 0.64 mmol), followed by anhydrous toluene (45 mL). Nitrogen was bubbled through the above solution via a needle for 1 h. Then palladium acetate (Aldrich Chemical Company) (18 mg, 0.08 mmol) and BINAP (Aldrich Chemical Company) (50 mg, 0.08 mmol) were added to the reaction in one portion, followed by sodium tert-butoxide (Aldrich Chemical Company) (145 mg, 1.5 mmol). The reaction mixture was heated at 90° C. overnight. After cooling to room temperature, the reaction mixture was taken up to ether, and washed with brine. The aqueous layer was extracted with ether (2×) and the combined ether layer was dried over Na2SO4 and concentrated. The residue was purified on a Biotage 40 S column (2.5:1 hexane:EtOAc) to give the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 366 (M+1). Mp: 207.4-207.5° C.
    Figure US20060030618A1-20060209-C00368
    Figure US20060030618A1-20060209-C00369
    • EXAMPLE 134
  • Figure US20060030618A1-20060209-C00370
    • 7-[4-(4-Trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinoline
  • To an oven-dried, 50-mL, round-bottomed flask were added 7-hydroxyquinoline (Aldrich) (87 mg, 0.6 mmol) and DMF (1 mL). The solution was place under nitrogen, and NaH (24 mg, 0.6 mmol) was added in one portion. After stirring for 10 min, 2-chloro-4-(4-trifluoromethylphenyl) pyridine (Example 410 (c), 129 mg, 0.5 mmol) was added. The reaction mixture was heated in a 155° C. oil bath for 72 h. After cooling to room temperature, the reaction mixture was partitioned between EtOAc and brine. The aqueous layer was extracted with EtOAc and the combined organic layers were dried over Na2SO4, concentrated in vacuo. The crude material was purified on a Biotage 40 S column (3:1 hexanes:EtOAc) to give the title compound as an off-white solid. MS (ESI, pos. ion) m/z: 367 (M+1). Mp: 156.5-158.5° C.
    • EXAMPLE 135
  • Figure US20060030618A1-20060209-C00371
    • 2-(3-Methoxy-phenoxy)-4-(4-trifluoromethyl-phenyl)-pyridine
  • This material was prepared according to the method described in Example 2 (d) using 2-chloro-4-(4-trifluoromethyl-phenyl)-pyridine (Example 410 (c), 129 mg, 0.5 mmol), 3-methoxyphenol (66 uL, 0.6 mmol), and sodium hydride (24 mg, 0.6 mmol) in DMF (1 mL). Purification on a Biotage 40S column (8:1 hexanes:EtOAc), provided the title compound as a white solid. MS (ESI, pos. ion) m/z: 346 (M+1). Mp: 77.5-79.6° C.
    • EXAMPLE 136
  • Figure US20060030618A1-20060209-C00372
    • 8-[4-(4-Trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinolin-2-ylamine
  • A mixture of 2-azido-quinolin-8-ol (0.28 g, 1.5 mmol), 2-chloro-4-(4-trifluoromethyl-phenyl)-pyridine (Example 410 (c), 0.26 g, 1 mmol), and sodium hydride (64 mg, 1.6 mmol) in DMF (2 mL) was heated in a 180° C. oil bath for 48 h. The reaction mixture was then transferred to a 5-mL tube, and irradiated in the Microwave Smith Synthesizer at 250° C. for 10 min. EtOAc and brine were added, and the aqueous layer was extracted with EtOAc. Combined organic layers were dried over Na2SO4, filtered, and concentrated in vacuo. The compound was purified on a Biotage 40S column (98:2 dichloromethane:MeOH) followed by recrystallization from EtOAc/hexanes to give the title compound as a light-yellow shiny crystal. MS (ESI, pos. ion) m/z: 382 (M+1). Mp: 196.5-199.5° C. Anal. Calcd for C21H14F3N3O: C, 66.14; H, 3.70; N, 11.02. Found: C, 66.18; H, 3.69; N, 11.08.
    • EXAMPLE 137
  • Figure US20060030618A1-20060209-C00373
    • 8-[4-(4-Trifluoromethyl-phenyl)-pyridin-2-yloxy]-quinoline
  • This material was prepared according to the method described in Example 413 using 2-chloro-4-(4-trifluoromethyl-phenyl)-pyridine (Example 410 (c), 0.16 g, 0.6 mmol), 8-hydroxyquinoline (0.1 g, 0.7 mmol), sodium hydride (38 mg, 1.0 mmol) and copper (I) iodide (12 mg, 0.06 mmol) in DMF (3 mL). Purification on a Biotage 40S column (3:1 hexanes:EtOAc), provided the title compound as a white solid. MS (ESI, pos. ion) m/z: 367 (M+1). Anal. Calcd for C21H13F3N2O: C, 68.85; H, 3.58; N, 7.65. Found: C, 68.88; H, 3.59; N, 7.51.
    • EXAMPLE 138
  • Figure US20060030618A1-20060209-C00374
    • 2-Methyl-5-[4-(4-trifluoromethyl-phenyl)-pyridin-2-yloxy]-benzothiazole
  • This material was prepared according to the method described in Example 413 using 2-chloro-4-(4-trifluoromethyl-phenyl)-pyridine (Example 410 (c), 0.16 g, 0.6 mmol), 2-methyl-5-benzothiazolol (0.12 g, 0.7 mmol), sodium hydride (38 mg, 1.0 mmol) and copper (I) iodide (12 mg, 0.06 mmol) in DMF (3 mL). Purification on a Biotage 40S column (3:1 hexanes:EtOAc), provided the title compound as a white solid. MS (ESI, pos. ion) m/z: 367 (M+1). Mp: 160.5-163.5° C. Anal. Calcd for C20H13F3N2OS. 0.25 H2O: C, 61.45; H, 3.48; N, 7.17; S, 8.20. Found: C, 61.45; H, 3.39; N, 7.17; S, 8.31.
    TABLE B
    The following compounds were prepared according to General Schemes III.a, III.b and III.c:
    MS (ESI, Melting
    Example Structure pos. ion) m/z Point ° C.
    139
    Figure US20060030618A1-20060209-C00375
         		388 (M + 1) 246.3-247.5
    140
    Figure US20060030618A1-20060209-C00376
         		428 (M − 1) 430 (M + 1)
    • ADDITIONAL EXAMPLES
  • Following the procedures described above, or with slight modifications thereof, and following procedures familiar to one of ordinary skill in the art, the following examples were prepared from commercially available reagents:
    Example Melting Mass Spec.
    number Structure Point (° C.) (ESI) m/z
    142
    Figure US20060030618A1-20060209-C00377
         		244 343 (M + 1)
    143
    Figure US20060030618A1-20060209-C00378
         		231 352, 354 (M, M + 2)
    144
    Figure US20060030618A1-20060209-C00379
         		159 311 (M + 1)
    145
    Figure US20060030618A1-20060209-C00380
         		>300  361 (M + 1)
    146
    Figure US20060030618A1-20060209-C00381
         		59-61 310 (M + 1)
    147
    Figure US20060030618A1-20060209-C00382
         		174-175 310 (M + 1)
    148
    Figure US20060030618A1-20060209-C00383
         		 97-102 340 (M + 1)
    149
    Figure US20060030618A1-20060209-C00384
         		148-152 337 (M + 1)
    150
    Figure US20060030618A1-20060209-C00385
         		233-237 453 (M + 1)
    151
    Figure US20060030618A1-20060209-C00386
         		oil 296 (M + 1)
    152
    Figure US20060030618A1-20060209-C00387
         		106-108 281 (M + 1)
    153
    Figure US20060030618A1-20060209-C00388
         		98-102 295 (M + 1)
    154
    Figure US20060030618A1-20060209-C00389
         		171-173 323 (M + 1)
    155
    Figure US20060030618A1-20060209-C00390
         		257 320 (M + 1)
    156
    Figure US20060030618A1-20060209-C00391
         		187-190 359 (M + 1)
    157
    Figure US20060030618A1-20060209-C00392
         		203 339 (M + 1)
    158
    Figure US20060030618A1-20060209-C00393
         		244-248 416 (M + 1)
    159
    Figure US20060030618A1-20060209-C00394
         		204 325 (M + 1)
    160
    Figure US20060030618A1-20060209-C00395
         		191 341 (M + 1)
    161
    Figure US20060030618A1-20060209-C00396
         		thin film 319 (M + 1)
    162
    Figure US20060030618A1-20060209-C00397
         		173 326 (M + 1)
    163
    Figure US20060030618A1-20060209-C00398
         		152 406 (M + 1)
    164
    Figure US20060030618A1-20060209-C00399
         		193 370 (M + 1)
    165
    Figure US20060030618A1-20060209-C00400
         		249 365 (M + 1)
    166
    Figure US20060030618A1-20060209-C00401
         		193 331 (M + 1)
    167
    Figure US20060030618A1-20060209-C00402
         		149 310 (M + 1)
    168
    Figure US20060030618A1-20060209-C00403
         		173 310 (M + 1)
    169
    Figure US20060030618A1-20060209-C00404
         		218 296 (M + 1)
    170
    Figure US20060030618A1-20060209-C00405
         		195 322 (M + 1)
    171
    Figure US20060030618A1-20060209-C00406
         		223 323 (M + 1)
    172
    Figure US20060030618A1-20060209-C00407
         		168 310 (M + 1)
    173
    Figure US20060030618A1-20060209-C00408
         		205 348 (M + 1)
    174
    Figure US20060030618A1-20060209-C00409
         		161 338 (M + 1)
    175
    Figure US20060030618A1-20060209-C00410
         		212 334 (M + 1)
    176
    Figure US20060030618A1-20060209-C00411
         		263 323 (M + 1)
    177
    Figure US20060030618A1-20060209-C00412
         		239 331 (M + 1)
    178
    Figure US20060030618A1-20060209-C00413
         		167 347 (M + 1)
    179
    Figure US20060030618A1-20060209-C00414
         		172 330 (M + 1)
    180
    Figure US20060030618A1-20060209-C00415
         		154 336 (M + 1)
    181
    Figure US20060030618A1-20060209-C00416
         		281 337 (M + 1)
    182
    Figure US20060030618A1-20060209-C00417
         		154 347 (M + 1)
    183
    Figure US20060030618A1-20060209-C00418
         		105 328 (M + 1)
    184
    Figure US20060030618A1-20060209-C00419
         		165 329 (M + 1)
    185
    Figure US20060030618A1-20060209-C00420
         		270 331 (M + 1)
    186
    Figure US20060030618A1-20060209-C00421
         		 68 331 (M + 1)
    187
    Figure US20060030618A1-20060209-C00422
         		261 320 (M + 1)
    188
    Figure US20060030618A1-20060209-C00423
         		277 321 (M + 1)
    189
    Figure US20060030618A1-20060209-C00424
         		194 319 (M + 1)
    190
    Figure US20060030618A1-20060209-C00425
         		101 319 (M + 1)
    200
    Figure US20060030618A1-20060209-C00426
         		258 336 (M + 1)
    201
    Figure US20060030618A1-20060209-C00427
         		178 352 (M + 1)
    202
    Figure US20060030618A1-20060209-C00428
         		196 395 (M + 1)
    203
    Figure US20060030618A1-20060209-C00429
         		222 333 (M + 1)
    204
    Figure US20060030618A1-20060209-C00430
         		218 391 (M + 1)
    205
    Figure US20060030618A1-20060209-C00431
         		296-298 348 (M + 1)
    206
    Figure US20060030618A1-20060209-C00432
         		189 515 (M)
    207
    Figure US20060030618A1-20060209-C00433
         		116-119 470 (M + 1)
    208
    Figure US20060030618A1-20060209-C00434
         		186 352 (M + 1)
    209
    Figure US20060030618A1-20060209-C00435
         		162-163 302 (M + 1)
    210
    Figure US20060030618A1-20060209-C00436
         		231-232 333 (M + 1)
    211
    Figure US20060030618A1-20060209-C00437
         		42-48 300 (M + 1)
    212
    Figure US20060030618A1-20060209-C00438
         		229-230 300 (M + 1)
    213
    Figure US20060030618A1-20060209-C00439
         		200-202 368 (M + 1)
    214
    Figure US20060030618A1-20060209-C00440
         		120 338 (M + 1)
    215
    Figure US20060030618A1-20060209-C00441
         		119 310 (M + 1)
    216
    Figure US20060030618A1-20060209-C00442
         		 69 352 (M + 1)
    217
    Figure US20060030618A1-20060209-C00443
         		amorphous glass 351 (M + 1)
    218
    Figure US20060030618A1-20060209-C00444
         		84-90 338 (M + 1)
    219
    Figure US20060030618A1-20060209-C00445
         		64-71 428 (M + 1)
    220
    Figure US20060030618A1-20060209-C00446
         		100-104 415 (M + 1)
    221
    Figure US20060030618A1-20060209-C00447
         		91-93 428 (M + 1)
    222
    Figure US20060030618A1-20060209-C00448
         		205-206 415 (M + 1)
    223
    Figure US20060030618A1-20060209-C00449
         		78-80 444 (M + 1)
    224
    Figure US20060030618A1-20060209-C00450
         		89-93 444 (M + 1)
    225
    Figure US20060030618A1-20060209-C00451
         		148-150 444 (M + 1)
    226
    Figure US20060030618A1-20060209-C00452
         		92-94 445 (M + 1)
    227
    Figure US20060030618A1-20060209-C00453
         		177-180 396 (M + 1)
    228
    Figure US20060030618A1-20060209-C00454
         		138-141 428 (M + 1)
    229
    Figure US20060030618A1-20060209-C00455
         		155 448 (M + 1)
    230
    Figure US20060030618A1-20060209-C00456
         		168 432 (M + 1)
    231
    Figure US20060030618A1-20060209-C00457
         		121-124 426 (M + 1)
    232
    Figure US20060030618A1-20060209-C00458
         		403 (M + 1)
    233
    Figure US20060030618A1-20060209-C00459
         		 87 513 (M + 1)
    234
    Figure US20060030618A1-20060209-C00460
         		415 (M + 1)
    235
    Figure US20060030618A1-20060209-C00461
         		amorphous 427 (M + 1)
    236
    Figure US20060030618A1-20060209-C00462
         		 56 499 (M + 1)
    237
    Figure US20060030618A1-20060209-C00463
         		497 (M + 1)
    238
    Figure US20060030618A1-20060209-C00464
         		207-208 395 (M + 1)
    239
    Figure US20060030618A1-20060209-C00465
         		188-189 423 (M + 1)
    240
    Figure US20060030618A1-20060209-C00466
         		198-199 380 (M + 1)
    241
    Figure US20060030618A1-20060209-C00467
         		201-203 394 (M + 1)
    242
    Figure US20060030618A1-20060209-C00468
         		171-173 381 (M + 1)
    243
    Figure US20060030618A1-20060209-C00469
         		118-120 422 (M + 1)
    244
    Figure US20060030618A1-20060209-C00470
         		101-103 408 (M + 1)
    245
    Figure US20060030618A1-20060209-C00471
         		126-128 408 (M + 1)
    246
    Figure US20060030618A1-20060209-C00472
         		185-186 394 (M + 1)
    247
    Figure US20060030618A1-20060209-C00473
         		182-184 423 (M + 1)
    248
    Figure US20060030618A1-20060209-C00474
         		194-196 381 (M + 1)
    249
    Figure US20060030618A1-20060209-C00475
         		206-208 394 (M + 1)
    250
    Figure US20060030618A1-20060209-C00476
         		200-201 427 (M + 1)
    251
    Figure US20060030618A1-20060209-C00477
         		199-200 379 (M + 1)
    252
    Figure US20060030618A1-20060209-C00478
         		236-237 441 (M + 1)
    253
    Figure US20060030618A1-20060209-C00479
         		169 356 (M + 1)
    254
    Figure US20060030618A1-20060209-C00480
         		256-258 331 (M + 1)
    255
    Figure US20060030618A1-20060209-C00481
         		264-266 394 (M + 1)
    256
    Figure US20060030618A1-20060209-C00482
         		102-103 365 (M + 1)
    257
    Figure US20060030618A1-20060209-C00483
         		137-138 391 (M + 1)
    258
    Figure US20060030618A1-20060209-C00484
         		198-200 391 (M + 1)
    259
    Figure US20060030618A1-20060209-C00485
         		171-173 402 (M + 1)
    260
    Figure US20060030618A1-20060209-C00486
         		158-160 409 (M + 1)
    261
    Figure US20060030618A1-20060209-C00487
         		168-170 365 (M + 1)
    262
    Figure US20060030618A1-20060209-C00488
         		179-180 395 (M + 1)
    263
    Figure US20060030618A1-20060209-C00489
         		117-119 411 (M + 1)
    264
    Figure US20060030618A1-20060209-C00490
         		187-189 388 (M + 1)
    265
    Figure US20060030618A1-20060209-C00491
         		154-157 402 (M + 1)
    266
    Figure US20060030618A1-20060209-C00492
         		160-161 395 (M + 1)
    267
    Figure US20060030618A1-20060209-C00493
         		152-153 422 (M + 1)
    268
    Figure US20060030618A1-20060209-C00494
         		186-188 364 (M + 1)
    269
    Figure US20060030618A1-20060209-C00495
         		134-135 409 (M + 1)
    270
    Figure US20060030618A1-20060209-C00496
         		182-185 381 (M + 1)
    271
    Figure US20060030618A1-20060209-C00497
         		171-173 395 (M + 1)
    272
    Figure US20060030618A1-20060209-C00498
         		101-105 369 (M + 1)
    273
    Figure US20060030618A1-20060209-C00499
         		176-178 411 (M + 1)
    274
    Figure US20060030618A1-20060209-C00500
         		196-199 392 (M + 1)
    275
    Figure US20060030618A1-20060209-C00501
         		146-148 382 (M + 1)
    276
    Figure US20060030618A1-20060209-C00502
         		231 363 (M + 1)
    277
    Figure US20060030618A1-20060209-C00503
         		161-162 367 (M + 1)
    278
    Figure US20060030618A1-20060209-C00504
         		108-110 425 (M + 1)
    279
    Figure US20060030618A1-20060209-C00505
         		186-187 409 (M + 1)
    280
    Figure US20060030618A1-20060209-C00506
         		160-162 381 (M + 1)
    281
    Figure US20060030618A1-20060209-C00507
         		181 363 (M + 1)
    282
    Figure US20060030618A1-20060209-C00508
         		amorphous 353 (M + 1)
    283
    Figure US20060030618A1-20060209-C00509
         		(oil) 366 (M)
    284
    Figure US20060030618A1-20060209-C00510
         		348 (M + 1)
    285
    Figure US20060030618A1-20060209-C00511
         		324 (M + 1)
    286
    Figure US20060030618A1-20060209-C00512
         		330 (M + 1)
    287
    Figure US20060030618A1-20060209-C00513
         		382 (M + 1)
    288
    Figure US20060030618A1-20060209-C00514
         		294 (M + 1)
    289
    Figure US20060030618A1-20060209-C00515
         		314 (M + 1)
    290
    Figure US20060030618A1-20060209-C00516
         		294 (M + 1)
    291
    Figure US20060030618A1-20060209-C00517
         		308 (M + 1)
    292
    Figure US20060030618A1-20060209-C00518
         		314 (M + 1)
    293
    Figure US20060030618A1-20060209-C00519
         		294 (M + 1)
    294
    Figure US20060030618A1-20060209-C00520
         		367 (M + 1)
    295
    Figure US20060030618A1-20060209-C00521
         		246-247 341 (M)
    296
    Figure US20060030618A1-20060209-C00522
         		328 (M + 1)
    297
    Figure US20060030618A1-20060209-C00523
         		233-235 341 (M)
    298
    Figure US20060030618A1-20060209-C00524
         		365 (M + 1)
    299
    Figure US20060030618A1-20060209-C00525
         		362 (M + 1)
    300
    Figure US20060030618A1-20060209-C00526
         		376 (M)
    301
    Figure US20060030618A1-20060209-C00527
         		372 (M + 1)
    302
    Figure US20060030618A1-20060209-C00528
         		186-187 391 (M + 1)
    303
    Figure US20060030618A1-20060209-C00529
         		224-226 414 (M + 1)
    304
    Figure US20060030618A1-20060209-C00530
         		231-232 331 (M + 1)
    305
    Figure US20060030618A1-20060209-C00531
         		219-220 349 (M + 1)
    306
    Figure US20060030618A1-20060209-C00532
         		231-232 383 (M + 1)
    307
    Figure US20060030618A1-20060209-C00533
         		203-204 365 (M + 1)
    308
    Figure US20060030618A1-20060209-C00534
         		117-179 365 (M + 1)
    309
    Figure US20060030618A1-20060209-C00535
         		226-227 384 (M + 1)
    310
    Figure US20060030618A1-20060209-C00536
         		Amorphous 308 (M + 1)
    311
    Figure US20060030618A1-20060209-C00537
         		150 360 (M)
    312
    Figure US20060030618A1-20060209-C00538
         		211 427 (M + 1)
    313
    Figure US20060030618A1-20060209-C00539
         		 78 433 (M + 1)
    314
    Figure US20060030618A1-20060209-C00540
         		286 350 (M + 1)
    315
    Figure US20060030618A1-20060209-C00541
         		Amorphous 434 (M + 1)
    316
    Figure US20060030618A1-20060209-C00542
         		226 415 (M + 1)
    317
    Figure US20060030618A1-20060209-C00543
         		219 530 (M + 1)
    318
    Figure US20060030618A1-20060209-C00544
         		Amorphous 320 (M + 1)
    319
    Figure US20060030618A1-20060209-C00545
         		Amorphous 415 (M + 1)
    320
    Figure US20060030618A1-20060209-C00546
         		211 349 (M + 1)
    321
    Figure US20060030618A1-20060209-C00547
         		Amorphous 375 (M + 1)
    322
    Figure US20060030618A1-20060209-C00548
         		Amorphous 341 (M + 1)
    323
    Figure US20060030618A1-20060209-C00549
         		Amorphous 427 (M + 1)
    324
    Figure US20060030618A1-20060209-C00550
         		225 360 (M + 1)
    325
    Figure US20060030618A1-20060209-C00551
         		Amorphous 338 (M + 1)
    326
    Figure US20060030618A1-20060209-C00552
         		275 320 (M + 1)
    327
    Figure US20060030618A1-20060209-C00553
         		282 332 (M + 1)
    328
    Figure US20060030618A1-20060209-C00554
         		209 332 (M + 1)
    329
    Figure US20060030618A1-20060209-C00555
         		Amorphous 430 (M + 1)
    330
    Figure US20060030618A1-20060209-C00556
         		197 443 (M + 1)
    331
    Figure US20060030618A1-20060209-C00557
         		Amorphous 332 (M + 1)
    332
    Figure US20060030618A1-20060209-C00558
         		Amorphous 448 (M)
    333
    Figure US20060030618A1-20060209-C00559
         		202 353 (M + 1)
    334
    Figure US20060030618A1-20060209-C00560
         		229 431 (M + 1)
    335
    Figure US20060030618A1-20060209-C00561
         		 97 449 (M + 1)
    336
    Figure US20060030618A1-20060209-C00562
         		121 309 (M)
    337
    Figure US20060030618A1-20060209-C00563
         		Amorphous 444 (M + 1)
    338
    Figure US20060030618A1-20060209-C00564
         		Amorphous 462 (M + 1)
    339
    Figure US20060030618A1-20060209-C00565
         		Amorphous 463 (M + 1)
    340
    Figure US20060030618A1-20060209-C00566
         		163 366 (M + 1)
    341
    Figure US20060030618A1-20060209-C00567
         		237-240 427 (M + 1)
    342
    Figure US20060030618A1-20060209-C00568
         		276-278 463 (M + 1)
    343
    Figure US20060030618A1-20060209-C00569
         		amorphous 423 (M + 1)
    344
    Figure US20060030618A1-20060209-C00570
         		202-204 476 (M + 1)
    345
    Figure US20060030618A1-20060209-C00571
         		214-218 451 (M + 1)
    346
    Figure US20060030618A1-20060209-C00572
         		amorphous 447 (M + 1)
    347
    Figure US20060030618A1-20060209-C00573
         		201-205 423 (M + 1)
    348
    Figure US20060030618A1-20060209-C00574
         		263-269 449 (M + 1)
    349
    Figure US20060030618A1-20060209-C00575
         		273-275 451 (M + 1)
    350
    Figure US20060030618A1-20060209-C00576
         		348 (M + 1)
    351
    Figure US20060030618A1-20060209-C00577
         		295 (M + 1)
    352
    Figure US20060030618A1-20060209-C00578
         		amorphous 417 (M + 1)
    353
    Figure US20060030618A1-20060209-C00579
         		308 (M + 1)
    354
    Figure US20060030618A1-20060209-C00580
         		328 (M + 1)
    355
    Figure US20060030618A1-20060209-C00581
         		amorphous 435 (M + 1)
    356
    Figure US20060030618A1-20060209-C00582
         		319 (M + 1)
    357
    Figure US20060030618A1-20060209-C00583
         		323 (M + 1)
    358
    Figure US20060030618A1-20060209-C00584
         		323 (M + 1)
    359
    Figure US20060030618A1-20060209-C00585
         		334 (M + 1)
    360
    Figure US20060030618A1-20060209-C00586
         		320 (M + 1)
    361
    Figure US20060030618A1-20060209-C00587
         		324 (M + 1)
    362
    Figure US20060030618A1-20060209-C00588
         		294 (M + 1)
    363
    Figure US20060030618A1-20060209-C00589
         		298 (M + 1)
    364
    Figure US20060030618A1-20060209-C00590
         		385 (M + 1)
    365
    Figure US20060030618A1-20060209-C00591
         		359 (M + 1)
    366
    Figure US20060030618A1-20060209-C00592
         		328 (M + 1)
    367
    Figure US20060030618A1-20060209-C00593
         		325 (M + 1)
    368
    Figure US20060030618A1-20060209-C00594
         		315 (M + 1)
    369
    Figure US20060030618A1-20060209-C00595
         		374 (M + 1)
    370
    Figure US20060030618A1-20060209-C00596
         		305 (M + 1)
    371
    Figure US20060030618A1-20060209-C00597
         		387 (M + 1)
    372
    Figure US20060030618A1-20060209-C00598
         		281 (M + 1)
    373
    Figure US20060030618A1-20060209-C00599
         		358 (M + 1)
    374
    Figure US20060030618A1-20060209-C00600
         		310 (M + 1)
    375
    Figure US20060030618A1-20060209-C00601
         		331 (M + 1)
    376
    Figure US20060030618A1-20060209-C00602
         		282 (M + 1)
    377
    Figure US20060030618A1-20060209-C00603
         		315 (M + 1)
    378
    Figure US20060030618A1-20060209-C00604
         		360 (M + 1)
    379
    Figure US20060030618A1-20060209-C00605
         		344 (M + 1)
    380
    Figure US20060030618A1-20060209-C00606
         		amorphous 449 (M + 1)
    381
    Figure US20060030618A1-20060209-C00607
         		amorphous 401 (M + 1)
    382
    Figure US20060030618A1-20060209-C00608
         		350 (M + 1)
    383
    Figure US20060030618A1-20060209-C00609
         		351 (M + 1)
    384
    Figure US20060030618A1-20060209-C00610
         		345 (M + 1)
    385
    Figure US20060030618A1-20060209-C00611
         		344 (M + 1)
    386
    Figure US20060030618A1-20060209-C00612
         		339 (M + 1)
    387
    Figure US20060030618A1-20060209-C00613
         		247-248 327 (M + 1)
    388
    Figure US20060030618A1-20060209-C00614
         		179-180 312 (M + 1)
    389
    Figure US20060030618A1-20060209-C00615
         		179-182 360, 362 (M, M + 2)
    390
    Figure US20060030618A1-20060209-C00616
         		182-183 282 (M + 1)
    391
    Figure US20060030618A1-20060209-C00617
         		187-188 316 (M + 1)
    392
    Figure US20060030618A1-20060209-C00618
         		195-196 300 (M + 1)
    393
    Figure US20060030618A1-20060209-C00619
         		201-202 350 (M + 1)
    394
    Figure US20060030618A1-20060209-C00620
         		214-216 325 (M + 1)
    395
    Figure US20060030618A1-20060209-C00621
         		150 360 (M + 1)
    396
    Figure US20060030618A1-20060209-C00622
         		184-189 350 (M + 1)
    397
    Figure US20060030618A1-20060209-C00623
         		173-175 296 (M + 1)
    398
    Figure US20060030618A1-20060209-C00624
         		160-165 318 (M + 1)
    399
    Figure US20060030618A1-20060209-C00625
         		200 350 (M + 1)
    400
    Figure US20060030618A1-20060209-C00626
         		203-207 332 (M + 1)
    401
    Figure US20060030618A1-20060209-C00627
         		155-158 326 (M + 1)
    402
    Figure US20060030618A1-20060209-C00628
         		181-182 318 (M + 1)
    403
    Figure US20060030618A1-20060209-C00629
         		196 408 (M + 1)
    404
    Figure US20060030618A1-20060209-C00630
         		185-186 332 (M + 1)
    405
    Figure US20060030618A1-20060209-C00631
         		(oil) 322 (M + 1)
    406
    Figure US20060030618A1-20060209-C00632
         		188 340 (M + 1)
    407
    Figure US20060030618A1-20060209-C00633
         		176 350 (M + 1)
    408
    Figure US20060030618A1-20060209-C00634
         		(oil) 326 (M + 1)
    409
    Figure US20060030618A1-20060209-C00635
         		129 366 (M + 1)
    410
    Figure US20060030618A1-20060209-C00636
         		202 396 (M + 1)
    411
    Figure US20060030618A1-20060209-C00637
         		191 362 (M + 1)
    412
    Figure US20060030618A1-20060209-C00638
         		165 324 (M + 1)
  • TABLE
    The following compounds were prepared according to General Schemes I, II or III:
    Example MS (ESI, Melting
    number Structure pos. ion) m/z Point ° C.
    413
    Figure US20060030618A1-20060209-C00639
         		303 (M + 1) 157
    414
    Figure US20060030618A1-20060209-C00640
         		333 (M + 1) amorphous
    415
    Figure US20060030618A1-20060209-C00641
         		347 (M + 1) 156
    416
    Figure US20060030618A1-20060209-C00642
         		321 (M + 1) 133
    417
    Figure US20060030618A1-20060209-C00643
         		393 (M + 1) amorphous
    418
    Figure US20060030618A1-20060209-C00644
         		342 (M + 1) 106
    419
    Figure US20060030618A1-20060209-C00645
         		360 (M + 1) 154
    420
    Figure US20060030618A1-20060209-C00646
         		354 (M + 1) 214
    421
    Figure US20060030618A1-20060209-C00647
         		372 (M + 1) 203
    422
    Figure US20060030618A1-20060209-C00648
         		366 (M + 1) 206
    423
    Figure US20060030618A1-20060209-C00649
         		373 (M + 1) 114
    424
    Figure US20060030618A1-20060209-C00650
         		383, 385 (M, M + 2) 124
    • ADDITIONAL EXAMPLES
  • Following the procedures described above, and applying the procedure in Example 109 to the cinnamides exemplified, or with slight modifications thereof, and following procedures familiar to one of ordinary skill in the art, the following examples may be prepared from commercially available reagents:
    Figure US20060030618A1-20060209-C00651
    Figure US20060030618A1-20060209-C00652
    Figure US20060030618A1-20060209-C00653
    Figure US20060030618A1-20060209-C00654
    Figure US20060030618A1-20060209-C00655
    Figure US20060030618A1-20060209-C00656
    Figure US20060030618A1-20060209-C00657
    Figure US20060030618A1-20060209-C00658
    Figure US20060030618A1-20060209-C00659
    Figure US20060030618A1-20060209-C00660
    Figure US20060030618A1-20060209-C00661
    Figure US20060030618A1-20060209-C00662
    Figure US20060030618A1-20060209-C00663
    Figure US20060030618A1-20060209-C00664
    Figure US20060030618A1-20060209-C00665
    Figure US20060030618A1-20060209-C00666
    Figure US20060030618A1-20060209-C00667
    Figure US20060030618A1-20060209-C00668
    Figure US20060030618A1-20060209-C00669
    Figure US20060030618A1-20060209-C00670
    Figure US20060030618A1-20060209-C00671
    Figure US20060030618A1-20060209-C00672
    Figure US20060030618A1-20060209-C00673
    Figure US20060030618A1-20060209-C00674
    Figure US20060030618A1-20060209-C00675
    Figure US20060030618A1-20060209-C00676
    Figure US20060030618A1-20060209-C00677
    Figure US20060030618A1-20060209-C00678
    Figure US20060030618A1-20060209-C00679
    Figure US20060030618A1-20060209-C00680
    Figure US20060030618A1-20060209-C00681
    Figure US20060030618A1-20060209-C00682
    Figure US20060030618A1-20060209-C00683
    Figure US20060030618A1-20060209-C00684
    Figure US20060030618A1-20060209-C00685
    Figure US20060030618A1-20060209-C00686
    Figure US20060030618A1-20060209-C00687
    Figure US20060030618A1-20060209-C00688
    Figure US20060030618A1-20060209-C00689
    Figure US20060030618A1-20060209-C00690
  • The following examples may also be made using the above generic schemes and synthetic examples:
    Figure US20060030618A1-20060209-C00691
    Figure US20060030618A1-20060209-C00692
    Capsaicin-Induced Ca2+ Influx in Primary Dorsal Root Ganglion Neurons
  • Embryonic 19 day old (E19) dorsal root ganglia (DRG) were dissected from timed-pregnant, terminally anesthetized Sprague-Dawley rats (Charles River, Wilmington, Mass.) and collected in ice-cold L-15 media (Life Technologies, Grand Island, N.Y.) containing 5% heat inactivated horse serum (Life Technologies). The DRG were then dissociated into single cell suspension using a papain dissociation system (Worthington Biochemical Corp., Freehold, N.J.). The dissociated cells were pelleted at 200×g for 5 min and re-suspended in EBSS containing 1 mg/ml ovomucoid inhibitor, 1 mg/ml ovalbumin and 0.005% DNase. Cell suspension was centrifuged through a gradient solution containing 10 mg/ml ovomucoid inhibitor, 10 mg/ml ovalbumin at 200×g for 6 min to remove cell debris; and filtered through a 88-μm nylon mesh (Fisher Scientific, Pittsburgh, Pa.) to remove any clumps. Cell number was determined with a hemocytometer and cells were seeded into poly-ornithine 100 μg/ml (Sigma) and mouse laminin 1 μg/ml (Life Technologies)-coated 96-well plates at 10×103 cells/well in complete medium. The complete medium consists of minimal essential medium (MEM) and Ham's F12, 1:1, penicillin (100 U/ml), and streptomycin (100 μg/ml), and nerve growth factor (10 ng/ml), 10% heat inactivated horse serum (Life Technologies). The cultures were kept at 37° C., 5% CO2 and 100% humidity. For controlling the growth of non-neuronal cells, 5-fluoro-2′-deoxyuridine (75 μM) and uridine (180 μM) were included in the medium. Activation of VR1 was achieved in these cellular assays using either a capsaicin stimulus (ranging from 0.01-10 μM) or by an acid stimulus (addition of 30 mM Hepes/Mes buffered at pH 4.1). Compounds were also tested in an assay format to evaluate their agonist properties at VR1. The activation of VR1 is followed as a function of cellular uptake of radioactive calcium (45Ca2+:Amersham CES3-2 mCi).
  • Capsaicin Antagonist Assay: E-19 DRG cells at 3 days in culture are incubated with serial concentrations of VR1 antagonists, in HBSS (Hanks buffered saline solution supplemented with BSA 0.1 mg/ml and 1 mM Hepes at pH 7.4) for 15 min, room temperature. Cells are then challenged with a VR1 agonist, capsaicin (500 nM), in activation buffer containing 0.1 mg/ml BSA, 15 mM Hepes, pH 7.4, and 10 μCi/ml 45Ca2+ (Amersham CES3-2 mCi) in Ham's F12 for 2 min at room temperature.
  • Acid Antagonist Assay: Compounds are pre-incubated with E-19 DRG cells at room temperature for 2 minutes prior to addition of 45Ca2+ in 30 mM Hepes/Mes buffer (Final Assay pH 5) and then left for an additional 2 minutes prior to compound washout. Final concentration of 45Ca2+ (Amersham CES3-2 mCi) is 10 μCi/mL.
  • Agonist Assay: Compounds are incubated with E-19 DRG cells at room temperature for 2 minutes in the presence of 45Ca2+ prior to compound washout. Final 45Ca2+ (Amersham CES3-2 mCi) at 10 μCi/mL.
  • Compound Washout and Analysis: Assay plates are washed using an ELX405 plate washer (Bio-Tek Instruments Inc.) immediately after functional assay. Wash 3× with PBS, 0.1 mg/mL BSA. Aspirate between washes. Read plates using a MicroBeta Jet (Wallac Inc.). Compound activity is then calculated using appropriate computational algorithms.
  • 45Calcium2+ Assay Protocol
  • Compounds may be assayed using Chinese Hamster Ovary cell lines stably expressing either human VR1 or rat VR1 under a CMV promoter. Cells could be cultured in a Growth Medium, routinely passaged at 70% confluency using trypsin and plated in an assay plate 24 hours prior to compound evaluation.
  • Possible Growth Medium:
      • DMEM, high glucose (Gibco 11965-084).
      • 10% Dialyzed serum (Hyclone SH30079.03).
      • 1× Non-Essential Amino Acids (Gibco 11140-050).
      • 1× Glutamine-Pen-Strep (Gibco 10378-016).
      • Geneticin, 450 μg/mL (Gibco 10131-035).
  • Compounds could be diluted in 100% DMSO and tested for activity over several log units of concentration [40 μM-2 pM]. Compounds may be further diluted in HBSS buffer (pH 7.4) 0.1 mg/mL BSA, prior to evaluation. Final DMSO concentration in assay would be 0.5-1%. Each assay plate could be controlled with a buffer only and a known antagonist compound (either capsazepine or one of the described VR1 antagonists).
  • Activation of VR1 could be achieved in these cellular assays using either a capsaicin stimulus (ranging from 0.1-1 μM) or by an acid stimulus (addition of 30 mM Hepes/Mes buffered at pH 4.1). Compounds could also be tested in an assay format to evaluate their agonist properties at VR1.
  • Capsaicin Antagonist Assay: Compounds may be pre-incubated with cells (expressing either human or rat VR1) at room temperature for 2 minutes prior to addition of 45Ca2+ and Capsaicin and then left for an additional 2 minutes prior to compound washout. Capsaicin (200 nM) can be added in HAM's F12, 0.1 mg/mL BSA, 15 mM Hepes at pH 7.4. Final 45Ca2+ (Amersham CES3-2 mCi) added could be 10μCi/mL.
  • Acid Antagonist Assay: Compounds can be pre-incubated with cells (expressing either human or rat VR1) for 2 minutes prior to addition of 45Ca2+ in 30 mM Hepes/Mes buffer (Final Assay pH 5) and then left for an additional 2 minutes prior to compound washout. Final 45Ca2+ (Amersham CES3-2 mCi) added could be 10 μCi/mL.
  • Agonist Assay: Compounds can be incubated with cells (expressing either human or rat VR1) for 2 minutes in the presence of 45Ca2+ prior to compound washout. Final 45Ca2+ (Amersham CES3-2 mCi) added could be 10 μCi/mL.
  • Compound Washout and Analysis: Assay plates would be washed using an ELX405 plate washer (Bio-Tek Instruments Inc.) immediately after the functional assay. One could wash 3× with PBS, 0.1 mg/mL BSA, aspirating between washes. Plates could then be read using a MicroBeta Jet (Wallac Inc.) and compound activity calculated using appropriate computational algorithms.
  • Useful nucleic acid sequences and proteins may be found in U.S. Pat. Nos. 6,335,180, 6,406,908 and 6,239,267, herein incorporated by reference in their entirety.
  • For the treatment of vanilloid-receptor-diseases, such as acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, the compounds of the present invention may be administered orally, parentally, by inhalation spray, rectally, or topically in dosage unit formulations containing conventional pharmaceutically acceptable carriers, adjuvants, and vehicles. The term parenteral as used herein includes, subcutaneous, intravenous, intramuscular, intrasternal, infusion techniques or intraperitoneally.
  • Treatment of diseases and disorders herein is intended to also include the prophylactic administration of a compound of the invention, a pharmaceutical salt thereof, or a pharmaceutical composition of either to a subject (i.e., an animal, preferably a mammal, most preferably a human) believed to be in need of preventative treatment, such as, for example, pain, inflammation and the like.
  • The dosage regimen for treating vanilloid-receptor-mediated diseases, cancer, and/or hyperglycemia with the compounds of this invention and/or compositions of this invention is based on a variety of factors, including the type of disease, the age, weight, sex, medical condition of the patient, the severity of the condition, the route of administration, and the particular compound employed. Thus, the dosage regimen may vary widely, but can be determined routinely using standard methods. Dosage levels of the order from about 0.01 mg to 30 mg per kilogram of body weight per day, preferably from about 0.1 mg to 10 mg/kg, more preferably from about 0.25 mg to 1 mg/kg are useful for all methods of use disclosed herein.
  • The pharmaceutically active compounds of this invention can be processed in accordance with conventional methods of pharmacy to produce medicinal agents for administration to patients, including humans and other mammals.
  • For oral administration, the pharmaceutical composition may be in the form of, for example, a capsule, a tablet, a suspension, or liquid. The pharmaceutical composition is preferably made in the form of a dosage unit containing a given amount of the active ingredient. For example, these may contain an amount of active ingredient from about 1 to 2000 mg, preferably from about 1 to 500 mg, more preferably from about 5 to 150 mg. A suitable daily dose for a human or other mammal may vary widely depending on the condition of the patient and other factors, but, once again, can be determined using routine methods.
  • The active ingredient may also be administered by injection as a composition with suitable carriers including saline, dextrose, or water. The daily parenteral dosage regimen will be from about 0.1 to about 30 mg/kg of total body weight, preferably from about 0.1 to about 10 mg/kg, and more preferably from about 0.25 mg to 1 mg/kg.
  • Injectable preparations, such as sterile injectable aqueous or oleaginous suspensions, may be formulated according to the known are using suitable dispersing or wetting agents and suspending agents. The sterile injectable preparation may also be a sterile injectable solution or suspension in a non-toxic parenterally acceptable diluent or solvent, for example as a solution in 1,3-butanediol. Among the acceptable vehicles and solvents that may be employed are water, Ringer's solution, and isotonic sodium chloride solution. In addition, sterile, fixed oils are conventionally employed as a solvent or suspending medium. For this purpose any bland fixed oil may be employed, including synthetic mono- or diglycerides. In addition, fatty acids such as oleic acid find use in the preparation of injectables.
  • Suppositories for rectal administration of the drug can be prepared by mixing the drug with a suitable non-irritating excipient such as cocoa butter and polyethylene glycols that are solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum and release the drug.
  • A suitable topical dose of active ingredient of a compound of the invention is 0.1 mg to 150 mg administered one to four, preferably one or two times daily. For topical administration, the active ingredient may comprise from 0.001% to 10% w/w, e.g., from 1% to 2% by weight of the formulation, although it may comprise as much as 10% w/w, but preferably not more than 5% w/w, and more preferably from 0. 1% to 1% of the formulation.
  • Formulations suitable for topical administration include liquid or semi-liquid preparations suitable for penetration through the skin (e.g., liniments, lotions, ointments, creams, or pastes) and drops suitable for administration to the eye, ear, or nose.
  • For administration, the compounds of this invention are ordinarily combined with one or more adjuvants appropriate for the indicated route of administration. The compounds may be admixed with lactose, sucrose, starch powder, cellulose esters of alkanoic acids, stearic acid, talc, magnesium stearate, magnesium oxide, sodium and calcium salts of phosphoric and sulfuric acids, acacia, gelatin, sodium alginate, polyvinyl-pyrrolidine, and/or polyvinyl alcohol, and tableted or encapsulated for conventional administration. Alternatively, the compounds of this invention may be dissolved in saline, water, polyethylene glycol, propylene glycol, ethanol, corn oil, peanut oil, cottonseed oil, sesame oil, tragacanth gum, and/or various buffers. Other adjuvants and modes of administration are well known in the pharmaceutical art. The carrier or diluent may include time delay material, such as glyceryl monostearate or glyceryl distearate alone or with a wax, or other materials well known in the art.
  • The pharmaceutical compositions may be made up in a solid form (including granules, powders or suppositories) or in a liquid form (e.g., solutions, suspensions, or emulsions). The pharmaceutical compositions may be subjected to conventional pharmaceutical operations such as sterilization and/or may contain conventional adjuvants, such as preservatives, stabilizers, wetting agents, emulsifiers, buffers etc.
  • Solid dosage forms for oral administration may include capsules, tablets, pills, powders, and granules. In such solid dosage forms, the active compound may be admixed with at least one inert diluent such as sucrose, lactose, or starch.
  • Such dosage forms may also comprise, as in normal practice, additional substances other than inert diluents, e.g., lubricating agents such as magnesium stearate. In the case of capsules, tablets, and pills, the dosage forms may also comprise buffering agents. Tablets and pills can additionally be prepared with enteric coatings.
  • Liquid dosage forms for oral administration may include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, and elixirs containing inert diluents commonly used in the art, such as water. Such compositions may also comprise adjuvants, such as wetting, sweetening, flavoring, and perfuming agents.
  • Compounds of the present invention can possess one or more asymmetric carbon atoms and are thus capable of existing in the form of optical isomers as well as in the form of racemic or non-racemic mixtures thereof. The optical isomers can be obtained by resolution of the racemic mixtures according to conventional processes, e.g., by formation of diastereoisomeric salts, by treatment with an optically active acid or base. Examples of appropriate acids are tartaric, diacetyltartaric, dibenzoyltartaric, ditoluoyltartaric, and camphorsulfonic acid and then separation of the mixture of diastereoisomers by crystallization followed by liberation of the optically active bases from these salts. A different process for separation of optical isomers involves the use of a chiral chromatography column optimally chosen to maximize the separation of the enantiomers. Still another available method involves synthesis of covalent diastereoisomeric molecules by reacting compounds of the invention with an optically pure acid in an activated form or an optically pure isocyanate. The synthesized diastereoisomers can be separated by conventional means such as chromatography, distillation, crystallization or sublimation, and then hydrolyzed to deliver the enantiomerically pure compound. The optically active compounds of the invention can likewise be obtained by using active starting materials. These isomers may be in the form of a free acid, a free base, an ester or a salt.
  • Likewise, the compounds of this invention may exist as isomers, that is compounds of the same molecular formula but in which the atoms, relative to one another, are arranged differently. In particular, the alkylene substituents of the compounds of this invention, are normally and preferably arranged and inserted into the molecules as indicated in the definitions for each of these groups, being read from left to right. However, in certain cases, one skilled in the art will appreciate that it is possible to prepare compounds of this invention in which these substituents are reversed in orientation relative to the other atoms in the molecule. That is, the substituent to be inserted may be the same as that noted above except that it is inserted into the molecule in the reverse orientation. One skilled in the art will appreciate that these isomeric forms of the compounds of this invention are to be construed as encompassed within the scope of the present invention.
  • The compounds of the present invention can be used in the form of salts derived from inorganic or organic acids. The salts include, but are not limited to, the following: acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulfate, butyrate, camphorate, camphorsulfonate, digluconate, cyclopentanepropionate, dodecylsulfate, ethanesulfonate, glucoheptanoate, glycerophosphate, hemisulfate, heptanoate, hexanoate, fumarate, hydrochloride, hydrobromide, hydroiodide, 2-hydroxyethanesulfonate, lactate, maleate, methansulfonate, nicotinate, 2-naphthalenesulfonate, oxalate, palmoate, pectinate, persulfate, 2-phenylpropionate, picrate, pivalate, propionate, succinate, tartrate, thiocyanate, tosylate, mesylate, and undecanoate. Also, the basic nitrogen-containing groups can be quaternized with such agents as lower alkyl halides, such as methyl, ethyl, propyl, and butyl chloride, bromides and iodides; dialkyl sulfates like dimethyl, diethyl, dibutyl, and diamyl sulfates, long chain halides such as decyl, lauryl, myristyl and stearyl chlorides, bromides and iodides, aralkyl halides like benzyl and phenethyl bromides, and others. Water or oil-soluble or dispersible products are thereby obtained.
  • Examples of acids that may be employed to from pharmaceutically acceptable acid addition salts include such inorganic acids as hydrochloric acid, sulfuric acid and phosphoric acid and such organic acids as oxalic acid, maleic acid, succinic acid and citric acid. Other examples include salts with alkali metals or alkaline earth metals, such as sodium, potassium, calcium or magnesium or with organic bases.
  • Also encompassed in the scope of the present invention are pharmaceutically acceptable esters of a carboxylic acid or hydroxyl containing group, including a metabolically labile ester or a prodrug form of a compound of this invention. A metabolically labile ester is one which may produce, for example, an increase in blood levels and prolong the efficacy of the corresponding non-esterified form of the compound. A prodrug form is one that is not in an active form of the molecule as administered but which becomes therapeutically active after some in vivo activity or biotransformation, such as metabolism, for example, enzymatic or hydrolytic cleavage. For a general discussion of prodrugs involving esters see Svensson and Tunek Drug Metabolism Reviews 165 (1988) and Bundgaard Design of Prodrugs, Elsevier (1985). Examples of a masked carboxylate anion include a variety of esters, such as alkyl (for example, methyl, ethyl), cycloalkyl (for example, cyclohexyl), aralkyl (for example, benzyl, p-methoxybenzyl), and alkylcarbonyloxyalkyl (for example, pivaloyloxymethyl). Amines have been masked as arylcarbonyloxymethyl substituted derivatives which are cleaved by esterases in vivo releasing the free drug and formaldehyde (Bungaard J. Med. Chem. 2503 (1989)). Also, drugs containing an acidic NH group, such as imidazole, imide, indole and the like, have been masked with N-acyloxymethyl groups (Bundgaard Design of Prodrugs, Elsevier (1985)). Hydroxy groups have been masked as esters and ethers. EP 039,051 (Sloan and Little, Apr. 11, 1981) discloses Mannich-base hydroxamic acid prodrugs, their preparation and use. Esters of a compound of this invention, may include, for example, the methyl, ethyl, propyl, and butyl esters, as well as other suitable esters formed between an acidic moiety and a hydroxyl containing moiety. Metabolically labile esters, may include, for example, methoxymethyl, ethoxymethyl, iso-propoxymethyl, a-methoxyethyl, groups such as α-((C1-C4)alkyloxy)ethyl, for example, methoxyethyl, ethoxyethyl, propoxyethyl, iso-propoxyethyl, etc.; 2-oxo-1,3-dioxolen-4-ylmethyl groups, such as 5-methyl-2-oxo-1,3,dioxolen-4-ylmethyl, etc.; C1-C3 alkylthiomethyl groups, for example, methylthiomethyl, ethylthiomethyl, isopropylthiomethyl, etc.; acyloxymethyl groups, for example, pivaloyloxymethyl, α-acetoxymethyl, etc.; ethoxycarbonyl-1-methyl; or α-acyloxy-α-substituted methyl groups, for example α-acetoxyethyl.
  • Further, the compounds of the invention may exist as crystalline solids which can be crystallized from common solvents such as ethanol, N,N-dimethyl-formamide, water, or the like. Thus, crystalline forms of the compounds of the invention may exist as polymorphs, solvates and/or hydrates of the parent compounds or their pharmaceutically acceptable salts. All of such forms likewise are to be construed as falling within the scope of the invention.
  • While the compounds of the invention can be administered as the sole active pharmaceutical agent, they can also be used in combination with one or more compounds of the invention or other agents. When administered as a combination, the therapeutic agents can be formulated as separate compositions that are given at the same time or different times, or the therapeutic agents can be given as a single composition.
  • The foregoing is merely illustrative of the invention and is not intended to limit the invention to the disclosed compounds. Variations and changes, which are obvious to one skilled in the art are intended to be within the scope and nature of the invention which are defined in the appended claims.
  • From the foregoing description, one skilled in the art can easily ascertain the essential characteristics of this invention, and without departing from the spirit and scope thereof, can make various changes and modifications of the invention to adapt it to various usages and conditions.

Claims (16)

1. A compound having the structure:
Figure US20060030618A1-20060209-C00693
wherein:
R1 is a naphthyl, the naphthyl is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
R is H, hydroxy, halo, C1-6alkyl substituted by 0, 1 or 2 substituents selected from R10,
Figure US20060030618A1-20060209-C00694
or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
R4is
Figure US20060030618A1-20060209-C00695
R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 0, 1, 2 or 3 substituents independently selected from C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRaC1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl and —NRaC(═O)C1-6alkyl; or R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O; except that when R1 is 4-chlorophenyl, 3-bromophenyl, 3-nitrophenyl, 2-nitro-3-chlorophenyl, 3,4-methylenedioxyphenyl, 3-methylthiophenyl or 2,3,4-methoxyphenyl, then R4 is not phenyl substituted by 1 or 2 substituents selected from halo and C1-4alkyl; and R1 and R4 are not both 3,4-methylenedioxyphenyl; and when R1 is 4-trifluoromethylphenyl, then R4is not pyridinyl, 2-methyl-4-aminoquinolinyl or 3,3-dimethyl-1,3-dihydro-indol-2-on-6-yl;
R5 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkyNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRaC1-6alkylORa; or R5 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S;
R6 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRa—C1-6alkylORa; or R5 and R6 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the bridge are substituted by 0, 1, 2 or 3 substituents selected from halo, C1-6alkyl, (═O), —OC1-6alkyl, —NRaC1-6alkyl, —C1-6alkylORa and C1-6alkylNRaRa, and the available N atoms of the bridge are substituted by Ra, —C1-6alkylORa or C1-6alkylNRaRa;
R7 is independently, at each instance, H, C1-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —OC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa or —NRa—C1-6alkylORa;
R10 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
R11 is independently, at each instance, H, C1-9alkyl, -C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R10 and R11 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc; wherein if R10, R12, R13 and R14 are all H, then R11 is not —O—C1-6alkylNRaRa or —O—C1-6alkylORa;
R12 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; or R11 and R12 together are a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRa—C(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc; or R10 and R11 together are -L3-NRa—, respectively, or -L4O—, respectively; or R11 and R12 are —NRa-L3-, -L3-NRa—, —O-L4- or -L4-O—; or R12 is —NRaRb; or R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O; or R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 atoms selected from O, N and S that is optionally vicinally fused with a saturated or unsaturated 3- or 4-atom bridge containing 0, 1, 2 or 3 atoms selected from O, N and S with the remaining atoms being carbon, so long as the combination of O and S atoms is not greater than 2, wherein the carbon atoms of the heterocycle and bridge are substituted by 1, 2 or 3 substituents independently selected from C2-9alkyl, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRa—C1-6alkyl and —NRaC(═O)C1-6alkyl;
R13 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
R14 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
Ra is independently, at each instance, H, phenyl, benzyl or C1-6alkyl;
Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra;
Rc is phenyl substituted by 0, 1 or 2 groups selected from halo, C1-3haloalkyl, —ORa and —NRaRa; or Rc is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the carbon atoms of the heterocycle are substituted by 0, 1 or 2 oxo groups, wherein the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-3haloalkyl, —ORa and —NRaRa;
L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkyNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
L4 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein at least one of the carbon atoms in the bridge is substituted by ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)OC1-6alkyl, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaC1-6alkyl, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
X is O, S or NRa;
Y is NH or O; and
n is independently, at each instance, 0, 1 or 2.
2. A compound according to claim 1, wherein:
R1 is a naphthyl, the naphthyl is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7;
R2 is H, hydroxy, halo, C1-6alkyl substituted by 0, 1 or 2 substituents selected from R10,
Figure US20060030618A1-20060209-C00696
or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7; and
R3 is H or C1-4alkyl.
3. A compound according to claim 2, wherein R2 is
Figure US20060030618A1-20060209-C00697
or a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
4. A compound according to claim 3, wherein R2 is
Figure US20060030618A1-20060209-C00698
5. A compound according to claim 3, wherein R2 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents independently selected from R5, R6 and R7.
6. A compound according to claim 2, wherein:
R4is
Figure US20060030618A1-20060209-C00699
Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-OR a; and
Y2 is —NRa— or —O—.
7. A compound according to claim 2, wherein:
R4is
Figure US20060030618A1-20060209-C00700
L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0 or 1 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRR a, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
Y2 is —NRb— or —O—.
8. A compound according to claim 2, wherein:
R4is
Figure US20060030618A1-20060209-C00701
L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(═O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
Y2 is —NRb or —O—.
9. A compound according to claim 2, wherein:
R4 is
Figure US20060030618A1-20060209-C00702
L3 is a 2- or 3-atom, saturated or unsaturated, bridge containing 1, 2 or 3 carbon atoms and 0, 1 or 2 atoms independently selected from O, N and S, wherein the each of the carbon atoms in the bridge is substituted by H, ═O, —ORa, —C1-6alkylORa, —C1-6alkyl, —NRaRa, —C1-6alkylNRaRa, —C(═O)ORa, —C(═O)NRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —OC(═O)C1-6alkyl, —NRaC(═O)C1-6alkyl, —C1-3alkylOC(═O)C1-6alkyl or —C1-3alkylNRaC(′O)C1-6alkyl, and any nitrogen atoms in the bridge are substituted by H, —C1-6alkylORa, —C1-6alkyl, —C1-6alkylNRaRa, —C1-3alkylC(═O)ORa, —C1-3alkylC(═O)NRaRa, —C1-3alkylOC(═O)C1-6alkyl, —C1-3alkylNRaC(═O)C1-6alkyl, —C(═O)Rc or —C1-3alkylRc;
Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
Y2 is —NRa— or —O—.
10. A compound according to claim 2, wherein:
R4is
Figure US20060030618A1-20060209-C00703
Rb is H, C1-6alkyl, —C(═O)C1-6alkyl, C1-6alkyl-O—Ra; and
Y2 is —NRa— or —O—.
11. A compound according to claim 2, wherein:
R4 is 10-membered bicyclic ring comprising fused 6-membered rings, containing 0, 1, 2, 3 or 4 N atoms with the remainder being carbon atoms, with at least one of the 6-membered rings being aromatic, wherein the carbon atoms are substituted by H, halo, ORa, NRaRa, C1-6alkyl and C1-3haloalkyl; and saturated carbon atoms may be additionally substituted by ═O.
12. A compound according to claim 2, wherein:
R4is
Figure US20060030618A1-20060209-C00704
R10 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
R11 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylRc, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; C1-6alkylNRaRa;
R12 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl;
R13 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, NRaRa, —NRaC1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRaC1-6alkyl or —NRaC(═O)C1-6alkyl; and
R14 is independently, at each instance, H, C1-9alkyl, —C1-3alkylORa, C1-4haloalkyl, halo, nitro, cyano, —ORa, —S(═O)nC1-6alkyl, —O—C1-4haloalkyl, —O—C1-6alkylNRaRa, —O—C1-6alkylORa, —O—C1-6alkylC(═O)ORa, —NRaRa, —NRa—C1-4haloalkyl, —NRa—C1-6alkylNRaRa, —NRa—C1-6alkylORa, —C(═O)C1-6alkyl, —C(═O)OC1-6alkyl, —OC(═O)C1-6alkyl, —C(═O)NRa—C1-6alkyl or —NRaC(═O)C1-6alkyl; wherein one of R10 and R12 is not H.
13. A compound according to claim 2, wherein R4 is a saturated or unsaturated 5- or 6-membered ring heterocycle containing 1, 2 or 3 heteroatoms independently selected from N, O and S, wherein no more than 2 of the ring members are O or S, wherein the heterocycle is optionally fused with a phenyl ring, and the heterocycle or fused phenyl ring is substituted by 0, 1, 2 or 3 substituents selected from halo, C1-4haloalkyl, —ORa and —NRaRa.
14. A compound according to claim 1, or a pharmaceutically-acceptable salt thereof, wherein the compounds is selected from:
Figure US20060030618A1-20060209-C00705
15. A method of treating acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders, comprising the step of administering a compound according to claim 1.
16. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically-acceptable diluent or carrier.
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