US20060025841A1 - Thalamic stimulation device - Google Patents

Thalamic stimulation device Download PDF

Info

Publication number
US20060025841A1
US20060025841A1 US11191867 US19186705A US2006025841A1 US 20060025841 A1 US20060025841 A1 US 20060025841A1 US 11191867 US11191867 US 11191867 US 19186705 A US19186705 A US 19186705A US 2006025841 A1 US2006025841 A1 US 2006025841A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
thalamus
stimulation
electrodes
electrical lead
lead
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11191867
Inventor
Cameron McIntyre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cleveland Clinic Foundation
Original Assignee
Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0529Electrodes for brain stimulation
    • A61N1/0534Electrodes for deep brain stimulation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system

Abstract

The present invention provides an electrical lead configured for stimulation of the thalamus. The electrical lead provides for preferential stimulation of the medial or lateral thalamus as well as specific nuclei within the thalamus, such as the intralaminar nuclei.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • The present application claims priority to U.S. Provisional Application No. 60/591,210, filed on Jul. 27, 2004, which is incorporated by reference herein.
  • FIELD OF THE INVENTION
  • The present application is directed to an implantable electrical stimulation device configured to stimulate target sites of the thalamus.
  • BACKGROUND OF THE INVENTION
  • Deep brain stimulation is becoming an increasingly preferred form of therapy for certain neurological conditions and disorders. Such therapy provides distinct advantages over surgical lesioning techniques, which are still being used to affects disorders such as Parkinson's disease, essential tremor, and dystonia. In particular, unlike surgical lesioning techniques, electrical stimulation is a reversible and adjustable procedure that provides continuous benefits as the patient's disease progresses and the patient's symptoms evolves. Currently, deep brain stimulation of the subthalamic nucleus and the globus pallidus interna is approved for treatment of Parkinson's disease and deep brain stimulation of the ventral intermediate nucleus is approved for treatment of essential tremor. Other target sites in the brain to treat additional disorders are also contemplated. For example, as described in U.S. Pat. No. 5,938,688 and U.S. Pat. No. 6,167,311, respectively, the intralaminar nuclei of the thalamus could be stimulated to treat patients with impaired cognitive function and/or patients with psychological disorders.
  • Current electrical leads used in deep brain stimulation, however, do not provide precise targeting of the areas of the thalamus such as the intralaminar nuclei, such that the desired volume of tissue is stimulated. Accordingly, there is a need in the art for a stimulation device that precisely targets specific regions of the thalamus, maximizing stimulation of these specific regions and minimizing stimulation of adjacent tissue that results undesirable side effects.
  • SUMMARY OF THE INVENTION
  • In an embodiment, the present invention provides a lead comprising a body having electrodes thereon. Preferably, the lead has any one of, all of, or any combination of the following features: the body having a diameter of between about 0.75 to about 1.25 millimeters (mm); the body having between about 4 to about 6 electrodes; electrodes that span about 110 to about 170 degrees about the body; and at least one of and preferably all of the electrodes having a height of between about 3 to about 4 millimeters.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The present invention will become more fully understood from the detailed description given hereinbelow and the accompanying drawings which are given by way of illustration only, and thus are not limitative of the present invention, and wherein:
  • FIG. 1 is a perspective view of a lead according to an embodiment of the present invention.
  • FIG. 2 is a schematic illustration of the volume of activation generated by an electrical lead of the present invention placed in the brain.
  • FIG. 3 is a schematic illustration of the volume of activation generated by an electrical lead of the present invention placed in the brain.
  • FIG. 4 is a schematic illustration of the volume of activation generated by an electrical lead of the present invention placed in the brain.
  • FIG. 5 is a schematic illustration of the volume of activation generated by an electrical lead of the prior art placed in the brain.
  • FIG. 6 is a diagrammatic view of a patient in which an embodiment of a lead according to the present invention has been implanted.
  • DETAILED DESCRIPTION OF THE INVENTION
  • Referring to FIG. 1, in an embodiment, the present invention provides an electrical lead 10 comprising a body 20 having electrodes 30 thereon. Preferably, electrical lead 10 has any one of, all of, or any combination of the following features: body 20 has a diameter D of between about 0.75 to about 1.25 millimeters (mm); body 20 has about 4 to about 6 electrodes 30 thereon; electrodes 30 each span about 110 to about 170 degrees about body 20; and at least one of and preferably all of electrodes 30 have a height H of between about 3 to about 4 mm.
  • Electrical lead 10 can be used to stimulated specific regions of the thalamus to provide precise directional stimulation of such specific regions. For example, referring to FIG. 2, which is a schematic illustration of electrical stimulation of regions of the thalamus by electrical lead 10 positioned in the thalamus, activation of electrode 30 b results in a volume of activation V that reaches the intralaminar nuclei as well as parts of the lateral thalamus 40. Such volume of activation is generated by -−3V, 90 microsecond, and approximately 50 hertz stimulation.
  • Referring to FIG. 3, under the same stimulation parameters, activation of electrode 30 a results in a volume of activation V that reaches the intralaminar nuclei as well as parts of the central medial nucleus of the medial thalamus 50. Referring to FIG. 4, activation of electrodes 30 a and 30 b results in a volume of activation V that reaches the intralaminar nuclei as well as parts of the medial thalamus 50 and lateral thalamus 40. Accordingly, depending on the particular therapeutic application, different electrodes 30 and different combinations of electrodes 30 of electrical lead 10 can be activated to provide different directional stimulation of specific regions of the thalamus, such as the lateral thalamus or the medial thalamus as well as nuclei within the lateral or medial thalamus, such as the intralaminar nuclei. Of course, electrical lead 10 is also capable of stimulating both the lateral and medial thalamus.
  • FIG. 5 is a schematic illustration of electrical stimulation of regions of the thalamus by a prior art electrical lead 60 positioned in the thalamus that has shorter and thicker electrodes 80 (four electrodes 80 in all) that each span 360 degrees about body 70 under the same stimulation parameters as used for stimulation depicted in FIGS. 1-4 (−3V, 90 microsecond, and approximately 50 hertz stimulation). Specifically, the upper two electrodes 80 of lead 60 are activated. As seen from a comparison of FIG. 4 and FIG. 5, electrical lead 10 of the present invention can generate the same shape of activation V as can prior art lead 60, but for given stimulation parameters, stimulation by electrical lead 10 of the present invention results in a greater volume of activation V than the volume of activation V generated by prior art leads. Electrical leads 10 of the present invention also provide additional flexibility in allowing for preferential stimulation of the lateral or medial thalamus.
  • Although not limited to any particular areas of the thalamus, the electrical lead of the present invention is particularly useful for stimulating the intralaminar nuclei, which include, for example, the centromedial nucleus, the parafascicular nucleus, the paracentral nucleus, the central lateral nucleus, and the central medial nucleus. The electrical lead 10 may also be used for preferential stimulation of one side or the other side of nuclei or a nucleus split by the internal medullary lamina.
  • Electrodes 30 of the present invention can be adjustably powerable. For example, the pulsing parameters of the electrodes 30 may be adjusted to initiate, stop, increase, or decrease the pole combinations, energy, amplitude, pulse width, waveform shape, frequency, and/or voltage or any other pulsing parameter known to one of skill in the art to adjust the degree of stimulation delivered thereby. In a preferred embodiment, each electrode 30 of body 20 of lead 10 is selectively powerable such that the pulsing parameters of an electrode 30 can be adjusted independent of the pulsing parameters of another electrode 30.
  • Referring to FIG. 6, the selective powerability over each electrode 30 may be achieved by employed a system including a programmer 520 coupled via a conductor 530 to a telemetry antenna 540. The programmer 520 is capable of sending signals via the telemetry antenna 540 to control the electrical signal delivered to electrodes 30 and, optionally, to control mechanism 100, in embodiments where control mechanism 100 is remotely operated. Such a system permits the selection of various pulse output options after lead 10 is implanted using telemetry communications. The present invention also contemplated radio-frequency systems to selectively power electrodes 30.
  • As will be understood by one of skill in the art, the independent powerability of electrodes 30 also provides a practitioner with another means of modify or steering the direction of stimulation as the locus of stimulation can be selectively adjusted to precisely target portions of the thalamus to achieve the desired therapy. For example, electrode 30 a may be powered to stimulate an area adjacent thereto while the signal to electrode 30 c may be substantially minimized to reduce or stop stimulation to an area adjacent to electrode 30 c. Because the locus of stimulation can be selectively adjusted and/or steered in this embodiment of lead 10, specific areas of the thalamus can be precisely targeted to achieve the desired therapy. Other or additional means of selectively steering electrical stimulation may also be utilized in the present invention, such as the methods described in U.S. Pat. No. 5,713,922, which is incorporated by reference herein.
  • A neural stimulation delivery system including lead 10 to stimulate neural tissue to affect a neurological condition may include other components useful in identifying, monitoring, or affecting a specific thalamic site or a particular neurological condition associated with the specific thalamic site. For example, such a system could include a component for lesioning and temperature monitoring, and/or a component that has a fiberoptic monitor which allows telemetric intracranial monitoring capabilities, and/or a microelectrode recording component, and/or a sensing component to incorporate a feedback mechanism to assist in determining whether lead 10 should be adjusted. With respect to a sensing component, referring to FIG. 6, a sensor 550 can be incorporated with a system of stimulating the thalamus according to the present invention. Sensor 550 can be used with a closed-loop feedback system in order to automatically determine the level of stimulation necessary to provide the desired therapy. Sensor 550 may be implanted into a portion of a patient P's body suitable for detecting characteristics, symptoms or attributes of the condition or disorder being treated such as electrical brain activity, cerebral blood flow, and/or vital signs or other chemical and electrical activity of the body. Sensors suitable for use in a system according to the present invention include, for example, those disclosed in U.S. Pat. No. 5,711,316, which is incorporated by reference herein. In cases where the attribute of the symptom is the electrical activity of the brain, stimulating electrodes may be intermittently used to record electrical activity. Alternatively, one or more electrodes implanted within the brain may serve as a sensor or a recording electrode. When necessary, these sensing or recording electrodes may deliver stimulation therapy to the thalamus. The output of an external feedback sensor may communicate with an implanted pulse generator through a telemetry down-link.
  • In order to advance lead 10 through a cannula, an actuator system that creates linear motion may be provided. Lead 10 may be provided within the cannula as part of the device or lead 10 may be installed during the surgical technique.
  • Preferably, lead 10 is capable of being bent, capable of being pre-bent such that lead 10 has a memory bend, or capable of being pre-formed into a desired shape that has memory. For example, lead 10 may be fabricated of a shape memory alloy such as nitinol.
  • The present invention contemplates that electrical lead 10 is not only capable of being adjusted intra-operatively, but also is capable of being adjusted post-operatively. Specifically, lead 10 positioning may be physically adjusted (advanced, retracted, or moved to a different location) in the brain post-operatively through the use of telemetry, RF signals, or other systems known in the art. The cannula need only be inserted once while lead 10 may be re-positioned in the brain tissue multiple times to reach the desired area of the brain. Further, electrodes 30 on lead 10 may be adjusted post-operatively by turning them on or off, adjusting the voltage, adjusting the frequency, and adjusting other electrical signal parameters through the use of telemetry, RF signals, or other systems known in the art. Those skilled in the art will appreciate that electrical properties of the electrodes 30 and the resulting electrical field may be varied by selectively powering individual or groups of electrodes 30 formed from or controlled by micro-electrical mechanical systems (MEMS). Moreover, MEMS actuators may drive electrodes, drug delivery catheters, sensing probes, and the like from the cannula to desired locations in an area of interest.
  • Furthermore, lead 10 may also be used in conjunction with brain stimulation modeling systems as described in U.S. patent application Ser. No. 10/885,982, filed on Jul. 7, 2004, entitled “Brain Stimulation Models, Systems, Devices, and Methods” (Attorney Docket. No. 01969.001US1), which is incorporated by reference herein.
  • The present invention may also be implemented within a drug delivery system to provide chemical stimulation utilizing a drug, pharmaceutical, or therapeutic agent. In this embodiment, the signal generator is replaced with or includes a pump and selected electrode is replaced with a catheter. The pump may be implanted below the skin of a patient and has a port into which a hypodermic needle can be inserted through the skin to inject a quantity of a liquid, such as a drug, pharmaceutical, or therapeutic agent. the liquid agent is delivered from a pump through a catheter port into a catheter. The catheter is positioned to deliver the liquid agent to specific infusion sites in the brain. Alternatively, the electrical lead may be combined with a drug delivery system to provide both chemical and electrical modulation to the thalamus.
  • Although the invention has been described with reference to the preferred embodiments, it will be apparent to one skilled in the art that variations and modifications are contemplated within the spirit and scope of the invention. The drawings and description of the preferred embodiments are made by way of example rather than to limit the scope of the invention, and it is intended to cover within the spirit and scope of the invention all such changes and modifications. The present invention incorporates by reference herein in its entirety U.S. patent application Ser. No. 10,602,319, filed on Jun. 24, 2003 entitled “Directional Electrode Design and Method of Using Same.”

Claims (7)

  1. 1. An electrical lead adapted for stimulation of the thalamus comprising:
    a body having a diameter of between about 0.75 to about 1.25 millimeters and having between about 4 to about 6 electrodes, the electrodes spanning about 110° to about 170° about the body and each of the electrodes having a height of between about 3 to about 4 millimeters.
  2. 2. The electrical lead of claim 1, wherein one or more of the electrodes are selectively powerable.
  3. 4. The electrical lead of claim 1, wherein the body is pre-bent or pre-formed into a desired shape.
  4. 5. The electrical lead of claim 4, wherein the body is fabricated of a shape memory alloy.
  5. 6. A method of selectively stimulating a region of the thalamus comprising:
    providing the electrical lead of claim 1;
    positioning the electrical lead of claim 1 adjacent to a region of the thalamus; and
    activating the electrical lead of claim 1 to stimulate the region of the thalamus.
  6. 7. The method of claim 6, wherein the region of the thalamus is the intralaminar nuclei.
  7. 8. The method of claim 6, wherein the region of the thalamus is the lateral or medial thalamus.
US11191867 2004-07-27 2005-07-27 Thalamic stimulation device Abandoned US20060025841A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US59121004 true 2004-07-27 2004-07-27
US11191867 US20060025841A1 (en) 2004-07-27 2005-07-27 Thalamic stimulation device

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11191867 US20060025841A1 (en) 2004-07-27 2005-07-27 Thalamic stimulation device

Publications (1)

Publication Number Publication Date
US20060025841A1 true true US20060025841A1 (en) 2006-02-02

Family

ID=35787806

Family Applications (1)

Application Number Title Priority Date Filing Date
US11191867 Abandoned US20060025841A1 (en) 2004-07-27 2005-07-27 Thalamic stimulation device

Country Status (3)

Country Link
US (1) US20060025841A1 (en)
EP (1) EP1786509A4 (en)
WO (1) WO2006015087A3 (en)

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090204193A1 (en) * 2008-02-12 2009-08-13 Intelect Medical, Inc. Directional lead assembly
US20100268298A1 (en) * 2009-04-16 2010-10-21 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US20110005069A1 (en) * 2009-07-07 2011-01-13 Boston Scientific Neuromodulation Corporation Systems and leads with a radially segmented electrode array and methods of manufacture
US20110130816A1 (en) * 2009-11-30 2011-06-02 Boston Scientific Neuromodulation Corporation Electrode array with electrodes having cutout portions and methods of making the same
US20110130803A1 (en) * 2009-11-30 2011-06-02 Boston Scientific Neuromodulation Corporation Electrode array having concentric windowed cylinder electrodes and methods of making the same
US20110238129A1 (en) * 2010-03-23 2011-09-29 Boston Scientific Neuromodulation Corporation Helical radial spacing of contacts on a cylindrical lead
US8560085B2 (en) 2011-02-08 2013-10-15 Boston Scientific Neuromodulation Corporation Methods for making leads with segmented electrodes for electrical stimulation systems
US8649879B2 (en) 2011-02-08 2014-02-11 Boston Scientific Neuromodulation Corporation Leads with retention features for segmented electrodes and methods of making and using the leads
US8694127B2 (en) 2010-09-21 2014-04-08 Boston Scientific Neuromodulation Corporation Systems and methods for making and using radially-aligned segmented electrodes for leads of electrical stimulation systems
US8700179B2 (en) 2011-02-02 2014-04-15 Boston Scientific Neuromodulation Corporation Leads with spiral of helical segmented electrode arrays and methods of making and using the leads
US8744596B2 (en) 2012-03-30 2014-06-03 Boston Scientific Neuromodulation Corporation Leads with X-ray fluorescent capsules for electrode identification and methods of manufacture and use
US8788063B2 (en) 2009-11-30 2014-07-22 Boston Scientific Neuromodulation Corporation Electrode array having a rail system and methods of manufacturing the same
US8792993B2 (en) 2012-06-01 2014-07-29 Boston Scientific, Neuromodulation Corporation Leads with tip electrode for electrical stimulation systems and methods of making and using
US20140249542A1 (en) * 2005-09-30 2014-09-04 Boston Scientific Neuromodulation Corporation Devices with cannula and electrode lead for brain stimulation and methods of use and manufacture
US8831742B2 (en) 2012-01-26 2014-09-09 Boston Scientific Neuromodulation Corporation Systems and methods for identifying the circumferential positioning of electrodes of leads for electrical stimulation systems
US8849415B2 (en) 2006-07-31 2014-09-30 Boston Scientific Neuromodulation Corporation Multi-channel connector for brain stimulation system
US8862242B2 (en) 2010-12-23 2014-10-14 Boston Scientific Neuromodulation Corporation Methods for making leads with segmented electrodes for electrical stimulation systems
US8868206B2 (en) 2010-06-18 2014-10-21 Boston Scientific Neuromodulation Corporation Electrode array having embedded electrodes and methods of making the same
US8874232B2 (en) 2009-11-30 2014-10-28 Boston Scientific Neuromodulation Corporation Electrode array having concentric split ring electrodes and methods of making the same
US8875391B2 (en) 2009-07-07 2014-11-04 Boston Scientific Neuromodulation Corporation Methods for making leads with radially-aligned segmented electrodes for electrical stimulation systems
US8897891B2 (en) 2012-08-03 2014-11-25 Boston Scientific Neuromodulation Corporation Leads with electrode carrier for segmented electrodes and methods of making and using
US8897889B2 (en) 2008-10-09 2014-11-25 Boston Scientific Neuromodulation Corporation Electrode design for leads of implantable electric stimulation systems and methods of making and using
US9089689B2 (en) 2013-08-30 2015-07-28 Boston Scientific Neuromodulation Corporation Methods of making segmented electrode leads using flanged carrier
US9149630B2 (en) 2013-05-31 2015-10-06 Boston Scientific Neuromodulation Corporation Segmented electrode leads formed from pre-electrodes with alignment features and methods of making and using the leads
US9162048B2 (en) 2013-05-15 2015-10-20 Boston Scientific Neuromodulation Corporation Systems and methods for making and using tip electrodes for leads of electrical stimulation systems
US9162049B2 (en) 2010-09-13 2015-10-20 Boston Scientific Neuromodulation Corporation Devices and methods for tissue modulation and monitoring
US9248272B2 (en) 2013-05-31 2016-02-02 Boston Scientific Neuromodulation Corporation Segmented electrode leads formed from pre-electrodes with depressions or apertures and methods of making and using
US9283394B2 (en) 2002-06-20 2016-03-15 Boston Scientific Neuromodulation Corporation Implantable microstimulators and methods for unidirectional propagation of action potentials
US9283375B2 (en) 2011-02-08 2016-03-15 Boston Scientific Neuromodulation Corporation Leads with segmented electrodes for electrical stimulation of planar regions and methods of making and using
US9289596B2 (en) 2013-07-12 2016-03-22 Boston Scientific Neuromodulation Corporation Leads with segmented electrodes and methods of making and using the leads
US9314614B2 (en) 2006-07-31 2016-04-19 Boston Scientific Neuromodulation Corporation Lead and methods for brain monitoring and modulation
US9381348B2 (en) 2013-05-31 2016-07-05 Boston Scientific Neuromodulation Corporation Leads with segmented electrodes and methods of making and using the leads
US9498620B2 (en) 2013-05-31 2016-11-22 Boston Scientific Neuromodulation Corporation Leads containing segmented electrodes with non-perpendicular legs and methods of making and using
US9561362B2 (en) 2014-11-10 2017-02-07 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved contact arrays for electrical stimulation systems
US9566747B2 (en) 2013-07-22 2017-02-14 Boston Scientific Neuromodulation Corporation Method of making an electrical stimulation lead
US9604068B2 (en) 2014-11-10 2017-03-28 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved connector contacts for electrical stimulation systems
US9656093B2 (en) 2015-07-16 2017-05-23 Boston Scientific Neuromodulation Corporation Systems and methods for making and using connector contact arrays for electrical stimulation systems
US9675795B2 (en) 2010-07-16 2017-06-13 Boston Scientific Neuromodulation Corporation Systems and methods for radial steering of electrode arrays
US9770598B2 (en) 2014-08-29 2017-09-26 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved connector contacts for electrical stimulation systems
US9775988B2 (en) 2013-12-02 2017-10-03 Boston Scientific Neuromodulation Corporation Electrical stimulation leads with helically arranged electrodes and methods of making and using
US9833611B2 (en) 2015-04-10 2017-12-05 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved contact arrays for electrical stimulation systems
US9956394B2 (en) 2015-09-10 2018-05-01 Boston Scientific Neuromodulation Corporation Connectors for electrical stimulation systems and methods of making and using
US9962541B2 (en) 2014-06-13 2018-05-08 Boston Scientific Neuromodulation Corporation Leads with electrode carriers for segmented electrodes and methods of making and using

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5711316A (en) * 1996-04-30 1998-01-27 Medtronic, Inc. Method of treating movement disorders by brain infusion
US5713922A (en) * 1996-04-25 1998-02-03 Medtronic, Inc. Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain
US5843148A (en) * 1996-09-27 1998-12-01 Medtronic, Inc. High resolution brain stimulation lead and method of use
US5938688A (en) * 1997-10-22 1999-08-17 Cornell Research Foundation, Inc. Deep brain stimulation method
US6094598A (en) * 1996-04-25 2000-07-25 Medtronics, Inc. Method of treating movement disorders by brain stimulation and drug infusion
US6167311A (en) * 1999-06-14 2000-12-26 Electro Core Techniques, Llc Method of treating psychological disorders by brain stimulation within the thalamus
US6208881B1 (en) * 1998-10-20 2001-03-27 Micropure Medical, Inc. Catheter with thin film electrodes and method for making same
US6510347B2 (en) * 2000-08-17 2003-01-21 William N. Borkan Spinal cord stimulation leads
US20050171587A1 (en) * 2003-11-25 2005-08-04 Advanced Neuromodulation Systems, Inc. Directional stimulation lead and orientation system
US7047084B2 (en) * 2002-11-20 2006-05-16 Advanced Neuromodulation Systems, Inc. Apparatus for directionally stimulating nerve tissue
US7047082B1 (en) * 1999-09-16 2006-05-16 Micronet Medical, Inc. Neurostimulating lead

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60124948D1 (en) * 2000-12-07 2007-01-11 Medtronic Inc Line to the directional stimulation and detection of the brain

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5713922A (en) * 1996-04-25 1998-02-03 Medtronic, Inc. Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain
US6094598A (en) * 1996-04-25 2000-07-25 Medtronics, Inc. Method of treating movement disorders by brain stimulation and drug infusion
US5711316A (en) * 1996-04-30 1998-01-27 Medtronic, Inc. Method of treating movement disorders by brain infusion
US5843148A (en) * 1996-09-27 1998-12-01 Medtronic, Inc. High resolution brain stimulation lead and method of use
US5938688A (en) * 1997-10-22 1999-08-17 Cornell Research Foundation, Inc. Deep brain stimulation method
US6208881B1 (en) * 1998-10-20 2001-03-27 Micropure Medical, Inc. Catheter with thin film electrodes and method for making same
US6167311A (en) * 1999-06-14 2000-12-26 Electro Core Techniques, Llc Method of treating psychological disorders by brain stimulation within the thalamus
US7047082B1 (en) * 1999-09-16 2006-05-16 Micronet Medical, Inc. Neurostimulating lead
US6510347B2 (en) * 2000-08-17 2003-01-21 William N. Borkan Spinal cord stimulation leads
US7047084B2 (en) * 2002-11-20 2006-05-16 Advanced Neuromodulation Systems, Inc. Apparatus for directionally stimulating nerve tissue
US20050171587A1 (en) * 2003-11-25 2005-08-04 Advanced Neuromodulation Systems, Inc. Directional stimulation lead and orientation system

Cited By (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9283394B2 (en) 2002-06-20 2016-03-15 Boston Scientific Neuromodulation Corporation Implantable microstimulators and methods for unidirectional propagation of action potentials
US8965529B2 (en) * 2005-09-30 2015-02-24 Boston Scientific Neuromodulation Corporation Devices with cannula and electrode lead for brain stimulation and methods of use and manufacture
US20140249542A1 (en) * 2005-09-30 2014-09-04 Boston Scientific Neuromodulation Corporation Devices with cannula and electrode lead for brain stimulation and methods of use and manufacture
US9314614B2 (en) 2006-07-31 2016-04-19 Boston Scientific Neuromodulation Corporation Lead and methods for brain monitoring and modulation
US8849415B2 (en) 2006-07-31 2014-09-30 Boston Scientific Neuromodulation Corporation Multi-channel connector for brain stimulation system
US8019440B2 (en) 2008-02-12 2011-09-13 Intelect Medical, Inc. Directional lead assembly
US9545510B2 (en) 2008-02-12 2017-01-17 Intelect Medical, Inc. Directional lead assembly with electrode anchoring prongs
US9089688B2 (en) 2008-02-12 2015-07-28 Intelect Medical, Inc. Directional lead assembly
US8634934B2 (en) 2008-02-12 2014-01-21 Intelect Medical, Inc. Directional lead assembly
US20090204193A1 (en) * 2008-02-12 2009-08-13 Intelect Medical, Inc. Directional lead assembly
US8897889B2 (en) 2008-10-09 2014-11-25 Boston Scientific Neuromodulation Corporation Electrode design for leads of implantable electric stimulation systems and methods of making and using
US8473061B2 (en) 2009-04-16 2013-06-25 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US20100268298A1 (en) * 2009-04-16 2010-10-21 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US9393403B2 (en) 2009-04-16 2016-07-19 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US9211402B2 (en) 2009-04-16 2015-12-15 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US8649873B2 (en) 2009-04-16 2014-02-11 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US8914121B2 (en) 2009-04-16 2014-12-16 Boston Scientific Neuromodulation Corporation Deep brain stimulation current steering with split electrodes
US8875391B2 (en) 2009-07-07 2014-11-04 Boston Scientific Neuromodulation Corporation Methods for making leads with radially-aligned segmented electrodes for electrical stimulation systems
US9913974B2 (en) 2009-07-07 2018-03-13 Boston Scientific Neuromodulation Corporation Methods for making leads with radially-aligned segmented electrodes for electrical stimulation systems
US9270070B2 (en) 2009-07-07 2016-02-23 Boston Scientific Neuromodulation Corporation Methods of manufacturing leads with a radially segmented electrode array
US8887387B2 (en) 2009-07-07 2014-11-18 Boston Scientific Neuromodulation Corporation Methods of manufacture of leads with a radially segmented electrode array
US20110005069A1 (en) * 2009-07-07 2011-01-13 Boston Scientific Neuromodulation Corporation Systems and leads with a radially segmented electrode array and methods of manufacture
US8666509B2 (en) 2009-11-30 2014-03-04 Boston Scientific Neuromodulation Corporation Electrode array with electrodes having cutout portions and methods of making the same
US20110130803A1 (en) * 2009-11-30 2011-06-02 Boston Scientific Neuromodulation Corporation Electrode array having concentric windowed cylinder electrodes and methods of making the same
US9168369B2 (en) 2009-11-30 2015-10-27 Boston Scientific Neuromodulation Corporation Electrode array having a rail system and methods of manufacturing the same
US20110130816A1 (en) * 2009-11-30 2011-06-02 Boston Scientific Neuromodulation Corporation Electrode array with electrodes having cutout portions and methods of making the same
US8391985B2 (en) 2009-11-30 2013-03-05 Boston Scientific Neuromodulation Corporation Electrode array having concentric windowed cylinder electrodes and methods of making the same
US8295944B2 (en) 2009-11-30 2012-10-23 Boston Scientific Neuromodulation Corporation Electrode array with electrodes having cutout portions and methods of making the same
US8874232B2 (en) 2009-11-30 2014-10-28 Boston Scientific Neuromodulation Corporation Electrode array having concentric split ring electrodes and methods of making the same
US8560074B2 (en) 2009-11-30 2013-10-15 Boston Scientific Neuromodulation Corporation Electrode array having concentric windowed cylinder electrodes and methods of making the same
US9248277B2 (en) 2009-11-30 2016-02-02 Boston Scientific Neuromodulation Corporation Electrode array having concentric split ring electrodes and methods of making the same
US8788063B2 (en) 2009-11-30 2014-07-22 Boston Scientific Neuromodulation Corporation Electrode array having a rail system and methods of manufacturing the same
US8442654B2 (en) 2009-11-30 2013-05-14 Boston Scientific Neuromodulation Corporation Electrode array with electrodes having cutout portions and methods of making the same
US8571665B2 (en) 2010-03-23 2013-10-29 Boston Scientific Neuromodulation Corporation Helical radial spacing of contacts on a cylindrical lead
US20110238129A1 (en) * 2010-03-23 2011-09-29 Boston Scientific Neuromodulation Corporation Helical radial spacing of contacts on a cylindrical lead
US9855417B2 (en) 2010-06-18 2018-01-02 Boston Scientific Neuromodulation Corporation Method of making an electrode array having embedded electrodes
US8868206B2 (en) 2010-06-18 2014-10-21 Boston Scientific Neuromodulation Corporation Electrode array having embedded electrodes and methods of making the same
US9675795B2 (en) 2010-07-16 2017-06-13 Boston Scientific Neuromodulation Corporation Systems and methods for radial steering of electrode arrays
US9162049B2 (en) 2010-09-13 2015-10-20 Boston Scientific Neuromodulation Corporation Devices and methods for tissue modulation and monitoring
US9795779B2 (en) 2010-09-21 2017-10-24 Boston Scientific Neuromodulation Corporation Systems and methods for making and using radially-aligned segmented electrodes for leads of electrical stimulation systems
US8694127B2 (en) 2010-09-21 2014-04-08 Boston Scientific Neuromodulation Corporation Systems and methods for making and using radially-aligned segmented electrodes for leads of electrical stimulation systems
US8862242B2 (en) 2010-12-23 2014-10-14 Boston Scientific Neuromodulation Corporation Methods for making leads with segmented electrodes for electrical stimulation systems
US9295830B2 (en) 2010-12-23 2016-03-29 Boston Scientific Neuromodulation Corporation Methods for making leads with segmented electrodes for electrical stimulation systems
US8700179B2 (en) 2011-02-02 2014-04-15 Boston Scientific Neuromodulation Corporation Leads with spiral of helical segmented electrode arrays and methods of making and using the leads
US9248276B2 (en) 2011-02-02 2016-02-02 Boston Scientific Neuromodulation Corporation Leads with spiral of helical segmented electrode arrays and methods of making and using the leads
US9248275B2 (en) 2011-02-08 2016-02-02 Boston Scientific Neuromodulation Corporation Methods of making leads with retention features for segmented electrodes
US8649879B2 (en) 2011-02-08 2014-02-11 Boston Scientific Neuromodulation Corporation Leads with retention features for segmented electrodes and methods of making and using the leads
US8560085B2 (en) 2011-02-08 2013-10-15 Boston Scientific Neuromodulation Corporation Methods for making leads with segmented electrodes for electrical stimulation systems
US9283375B2 (en) 2011-02-08 2016-03-15 Boston Scientific Neuromodulation Corporation Leads with segmented electrodes for electrical stimulation of planar regions and methods of making and using
US8831742B2 (en) 2012-01-26 2014-09-09 Boston Scientific Neuromodulation Corporation Systems and methods for identifying the circumferential positioning of electrodes of leads for electrical stimulation systems
US8923982B2 (en) 2012-03-30 2014-12-30 Boston Scientific Neuromodulation Corporation Leads with X-ray fluorescent capsules for electrode identification and methods of manufacture and use
US8744596B2 (en) 2012-03-30 2014-06-03 Boston Scientific Neuromodulation Corporation Leads with X-ray fluorescent capsules for electrode identification and methods of manufacture and use
US8996132B2 (en) 2012-06-01 2015-03-31 Boston Scientific Neuromodulation Corporation Leads with tip electrode for electrical stimulation systems and methods of making and using
US8792993B2 (en) 2012-06-01 2014-07-29 Boston Scientific, Neuromodulation Corporation Leads with tip electrode for electrical stimulation systems and methods of making and using
US9427567B2 (en) 2012-08-03 2016-08-30 Boston Scientific Neuromodulation Corporation Leads with electrode carrier for segmented electrodes and methods of making and using
US9227050B2 (en) 2012-08-03 2016-01-05 Boston Scientific Neuromodulation Corporation Leads with electrode carrier for segmented electrodes and methods of making and using
US8897891B2 (en) 2012-08-03 2014-11-25 Boston Scientific Neuromodulation Corporation Leads with electrode carrier for segmented electrodes and methods of making and using
US9162048B2 (en) 2013-05-15 2015-10-20 Boston Scientific Neuromodulation Corporation Systems and methods for making and using tip electrodes for leads of electrical stimulation systems
US9616220B2 (en) 2013-05-15 2017-04-11 Boston Scientific Neuromodulation Corporation Systems and methods for making and using tip electrodes for leads of electrical stimulation systems
US9149630B2 (en) 2013-05-31 2015-10-06 Boston Scientific Neuromodulation Corporation Segmented electrode leads formed from pre-electrodes with alignment features and methods of making and using the leads
US9381347B2 (en) 2013-05-31 2016-07-05 Boston Scientific Neuromodulation Corporation Segmented electrode leads formed from pre-electrodes with alignment features and methods of making and using the leads
US9498620B2 (en) 2013-05-31 2016-11-22 Boston Scientific Neuromodulation Corporation Leads containing segmented electrodes with non-perpendicular legs and methods of making and using
US9381348B2 (en) 2013-05-31 2016-07-05 Boston Scientific Neuromodulation Corporation Leads with segmented electrodes and methods of making and using the leads
US9248272B2 (en) 2013-05-31 2016-02-02 Boston Scientific Neuromodulation Corporation Segmented electrode leads formed from pre-electrodes with depressions or apertures and methods of making and using
US9289596B2 (en) 2013-07-12 2016-03-22 Boston Scientific Neuromodulation Corporation Leads with segmented electrodes and methods of making and using the leads
US9566747B2 (en) 2013-07-22 2017-02-14 Boston Scientific Neuromodulation Corporation Method of making an electrical stimulation lead
US9089689B2 (en) 2013-08-30 2015-07-28 Boston Scientific Neuromodulation Corporation Methods of making segmented electrode leads using flanged carrier
US9775988B2 (en) 2013-12-02 2017-10-03 Boston Scientific Neuromodulation Corporation Electrical stimulation leads with helically arranged electrodes and methods of making and using
US9962541B2 (en) 2014-06-13 2018-05-08 Boston Scientific Neuromodulation Corporation Leads with electrode carriers for segmented electrodes and methods of making and using
US9770598B2 (en) 2014-08-29 2017-09-26 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved connector contacts for electrical stimulation systems
US9604068B2 (en) 2014-11-10 2017-03-28 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved connector contacts for electrical stimulation systems
US9561362B2 (en) 2014-11-10 2017-02-07 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved contact arrays for electrical stimulation systems
US9764149B2 (en) 2014-11-10 2017-09-19 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved connector contacts for electrical stimulation systems
US9833611B2 (en) 2015-04-10 2017-12-05 Boston Scientific Neuromodulation Corporation Systems and methods for making and using improved contact arrays for electrical stimulation systems
US9839787B2 (en) 2015-07-16 2017-12-12 Boston Scientific Neuromodulation Corporation Systems and methods for making and using connector contact arrays for electrical stimulation systems
US9656093B2 (en) 2015-07-16 2017-05-23 Boston Scientific Neuromodulation Corporation Systems and methods for making and using connector contact arrays for electrical stimulation systems
US9956394B2 (en) 2015-09-10 2018-05-01 Boston Scientific Neuromodulation Corporation Connectors for electrical stimulation systems and methods of making and using

Also Published As

Publication number Publication date Type
WO2006015087A2 (en) 2006-02-09 application
EP1786509A2 (en) 2007-05-23 application
EP1786509A4 (en) 2010-01-13 application
WO2006015087A3 (en) 2007-02-08 application

Similar Documents

Publication Publication Date Title
US7890176B2 (en) Methods and systems for treating chronic pelvic pain
US5713922A (en) Techniques for adjusting the locus of excitation of neural tissue in the spinal cord or brain
US5716377A (en) Method of treating movement disorders by brain stimulation
US6922590B1 (en) Systems and methods for treatment of diabetes by electrical brain stimulation and/or drug infusion
US6018682A (en) Implantable seizure warning system
US7769461B2 (en) Skull-mounted electrical stimulation system and method for treating patients
US6484059B2 (en) Method for optimized brain stimulation for treating movement disorders
US6597953B2 (en) Furcated sensing and stimulation lead
US7209787B2 (en) Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US5713923A (en) Techniques for treating epilepsy by brain stimulation and drug infusion
US6871099B1 (en) Fully implantable microstimulator for spinal cord stimulation as a therapy for chronic pain
US7421297B2 (en) Monopolar stimulation assembly including at least one remote electrode
US20080027503A1 (en) Vagus Nerve Stimulation by Electrical Signals for Controlling Cerebellar Tremor
US20040127942A1 (en) Medical device for neural stimulation and controlled drug delivery
US20090112282A1 (en) Occipital nerve stimulation
US20070255320A1 (en) Method and apparatus for forming insulated implantable electrodes
US7668601B2 (en) Implantable medical lead with multiple electrode configurations
US20070049988A1 (en) Optimal electrode contact polarity configurations for implantable stimulation systems
US6529774B1 (en) Extradural leads, neurostimulator assemblies, and processes of using them for somatosensory and brain stimulation
US20110106220A1 (en) Extracranial implantable devices, systems and methods for the treatment of neurological disorders
US20050283200A1 (en) Methods of treating medical conditions by neuromodulation of the cerebellar pathways
US7277758B2 (en) Methods and systems for predicting future symptomatology in a patient suffering from a neurological or psychiatric disorder
US20050119703A1 (en) Apparatus and method for closed-loop intracranial stimulation for optimal control of neurological disease
US6832115B2 (en) Catheter leads for the intrathecal space and method of use
US20060184211A1 (en) Method of routing electrical current to bodily tissues via implanted passive conductors

Legal Events

Date Code Title Description
AS Assignment

Owner name: THE CLEVELAND CLINIC FOUNDATION, OHIO

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MCINTYRE, CAMERON;REEL/FRAME:017140/0240

Effective date: 20051004