New! View global litigation for patent families

US20060009756A1 - Method and devices for treating atrial fibrillation by mass ablation - Google Patents

Method and devices for treating atrial fibrillation by mass ablation Download PDF

Info

Publication number
US20060009756A1
US20060009756A1 US11128786 US12878605A US2006009756A1 US 20060009756 A1 US20060009756 A1 US 20060009756A1 US 11128786 US11128786 US 11128786 US 12878605 A US12878605 A US 12878605A US 2006009756 A1 US2006009756 A1 US 2006009756A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
tissue
ablation
target
ablator
apparatus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US11128786
Inventor
David Francischelli
Mark Stewart
James Skarda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/06Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating caused by chemical reaction, e.g. moxaburners
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/149Probes or electrodes therefor bow shaped or with rotatable body at cantilever end, e.g. for resectoscopes, or coagulating rollers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00Ultrasound therapy
    • A61N7/02Localised ultrasound hyperthermia
    • A61N7/022Localised ultrasound hyperthermia intracavitary
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • A61B17/2202Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement the ultrasound transducer being inside patient's body at the distal end of the catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/00267Expandable means emitting energy, e.g. by elements carried thereon having a basket shaped structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00273Anchoring means for temporary attachment of a device to tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00273Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00279Anchoring means for temporary attachment of a device to tissue deployable
    • A61B2018/00285Balloons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00273Anchoring means for temporary attachment of a device to tissue
    • A61B2018/00291Anchoring means for temporary attachment of a device to tissue using suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • A61B2018/00357Endocardium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • A61B2018/00363Epicardium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577Ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636Sensing and controlling the application of energy
    • A61B2018/00773Sensed parameters
    • A61B2018/00839Bioelectrical parameters, e.g. ECG, EEG
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B2018/1405Electrodes having a specific shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B2018/1472Probes or electrodes therefor for use with liquid electrolyte, e.g. virtual electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A61B2018/1861Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument instered into a body lumen or cavity, e.g. a catheter

Abstract

Apparatus and method for ablating target tissue including a non-linear area of tissue in the left atrium of a patient. The method can include selecting an ablation apparatus having an ablator with a tissue engagement section, penetrating a chest cavity of the patient, and identifying the target tissue. The method can also include positioning the ablation apparatus adjacent to the target tissue so that the tissue engagement section can transfer ablation energy to the target tissue. The method can further include energizing the tissue engagement section with ablation energy in order to create a footprint on the non-linear area of tissue in the left atrium and to reduce an overall mass of excitable tissue in the left atrium.

Description

    RELATED APPLICATIONS
  • [0001]
    This application claims the benefit of the filing date of U.S. Provisional Patent Application No. 60/571,182 filed on May 14, 2004, which is incorporated herein by reference in its entirety.
  • FIELD OF THE INVENTION
  • [0002]
    The present invention relates to tools and procedures generally and relates more particularly to the use of ablation to reduce the mass of excitable tissue of the left atrium to prevent and treat atrial fibrillation or other medical conditions.
  • BACKGROUND
  • [0003]
    Focal triggers initiating atrial fibrillation are thought to frequently arise from the pulmonary veins and their ostia. Surgeons have used the technique of modifying the substrate of the heart in these areas to prevent the propagation of the arrhythmia. In some patients with chronic atrial fibrillation, the Cox/MAZE III procedure has been employed. This procedure controls propagation of the depolarization wavefronts in the right and left atria by means of surgical incisions through the walls of the right and left atria. The incisions create blind or dead end conduction pathways, which prevent re-entrant atrial tachycardias from occurring.
  • [0004]
    While the Cox/MAZE procedure is successful in treating atrial fibrillation, the procedure is quite complex and is currently practiced by only a few very skilled cardiac surgeons in conjunction with other open-heart procedures. The procedure also is quite traumatic to the heart, as in essence, the right and left atria are cut into pieces and sewed back together, to define lines of lesion across which the depolarization wavefronts will not propagate. Still today, the Cox/MAZE procedure is done with traditional cut and sew techniques.
  • [0005]
    The market is demanding quicker, safer and less invasive approaches. As a result, there has been much recent research and evaluation of mechanisms to encircle and isolate the pulmonary veins and replicate the incisions of the MAE operation. Companies are developing ablation techniques that heat (or cool) or chemically destroy the underlying tissue along these lines.
  • [0006]
    It has been suggested that procedures similar to the MAZE procedure could be instead, performed by means of electrosurgical ablation, for example, by applying radio frequency energy to internal or external surfaces of the atria to create lesions across which the depolarization wavefronts will not propagate. Such procedures are disclosed in U.S. Pat. No. 5,895,417, issued to Pomeranz, et al. (“the Pomeranz '417 patent”); U.S. Pat. No. 5,575,766, issued to Swartz, et al. (“the Swartz '766 patent”); U.S. Pat. No. 6,032,077, issued to Pomeranz (“the Pomeranz '077 patent”); U.S. Pat. No. 6,142,994, issued to Swanson, et al. (“the Swanson '994 patent”); and U.S. Pat. No. 5,871,523, issued to Fleischman, et al. (“the Fleischman '523 patent”), all incorporated herein by reference in their entireties.
  • [0007]
    The Pomeranz '417 patent discloses an apparatus for ablating tissue by making linear lesions within the chamber of a patient's heart by application of a plurality of spaced electrodes along an elongate member. The Schwartz '766 patent discloses a process for treating atrial arrhythmia by creating discrete ablation tracks within both the left and right atrium. The Pomeranz '077 patent discloses an ablation catheter that is electrically connected to tissue to be ablated by a foam on the electrodes that is soaked in saline. The foam in the Pomeranz '077 patent acts as a conductive fluid to allow energy from the electrode to ablate the contacted tissue. The Swanson '994 patent discloses a surgical method and apparatus for positioning an element in the body of a patient for diagnosis or therapy. The apparatus in the Swanson '994 patent may be a catheter or a probe having a shaft with a lumen extending there through. The Fleischman '523 patent discloses a helically-wound emitter on an element with a insulating sheath movable over the emitter.
  • [0008]
    Various types of electrophysiology devices are used for ablating tissue. Typically, such devices include a conductive tip or blade that serves as one electrode in an electrical circuit that is completed via a grounding electrode coupled to the patient. The contact point is small or linear to create lesions to form linear tracks of ablated tissue. A power source creates high levels of electrical energy between the two electrodes causing the tissue to heat to a sufficient level to denature proteins within the tissue and cause cell death. In order for such procedures to be effective, it is desirable that the electrosurgically-created lesions are continuous along their length and extend completely through the tissue of the heart.
  • [0009]
    Manufacturers have developed catheters that have a linear array of electrodes along a long axis (e.g., the Amazr, MECCA, and Revelation catheters). The surgeon positions the catheter and electrodes in contact with the tissue and either individually or sequentially applies energy to each electrode. Additionally, catheters that incorporate an electrode that is energized and moves along its length have been proposed, such as the Flex-10 from AFx, Inc., of 47929 Fremont Aye, Fremont, Calif. 94538.
  • [0010]
    Surgeons have also been able to create linear lesions on the heart using applications of the same techniques. For example, Kottkamp, et. al. in an article entitled “Intraoperative Radio Frequency Ablation of Chronic Atrial Fibrillation: A Left Atrial Curative Approach by Elimination of Anatomic ‘Anchor’ Reentrant Circuits,” Journal of Cardiovascular Electrophysiology, 10:772-780 (1999), describe a hand-held device that creates as series of spot or short (less than 1 cm) linear lesions. Other investigators have used long, linear unipolar probes to create somewhat longer lesions. Still others have used multi-electrode linear catheters, similar to those described above to create a series of ablations that net a linear lesion.
  • [0011]
    The focus of most investigators has been to isolate the pulmonary veins. There is growing research that suggests this may not be necessary in the prevention and cure of atrial fibrillation, as discussed in the article by G. Stabile, P. Turco, V. La Rocca, P. Nocerino, E. Stabile, and A. Dc Simone entitled “Is Pulmonary Vein Isolation Necessary for Curing Atrial Fibrillation?,” Circulation, 108:657-660 (2003). Rather than focusing on only isolating the pulmonary veins, reduction in the overall volume of excitable tissue in the left atrium is sufficient to prevent atrial fibrillation. The general concept is to ablate a large enough nonlinear area of the left atrium to prevent re-entrant waves and the propagation of atrial fibrillation.
  • SUMMARY OF THE INVENTION
  • [0012]
    Some embodiments of the invention provide a method of ablating target tissue including a non-linear area of tissue in the left atrium of a patient. The method can include selecting an ablation apparatus having an ablator or ablation member with a tissue engagement section, penetrating a chest cavity of the patient, and identifying the target tissue. The method can also include positioning the ablation apparatus adjacent to the target tissue so that the tissue engagement section can transfer ablation energy to the target tissue. The method can further include energizing the tissue engagement section with ablation energy in order to create a footprint on the non-linear area of tissue in the left atrium and to reduce an overall mass of excitable tissue in the left atrium.
  • [0013]
    In some embodiments, an ablation apparatus can include an insertion tool having a proximal end, a distal end, and a lumen. The ablation apparatus can include an ablator or ablation member having a conductor and a tissue engagement portion. The conductor can include a source end extending from the proximal end of the insertion tool and a delivery end coupled to the tissue engagement portion. The ablator can be removably inserted in the lumen. The ablation apparatus can also include an energy source connected to the conductor. The insertion tool can be inserted into a patient so that the distal end is adjacent the target tissue. The conductor can urge the ablator out of the lumen to engage the target tissue. Energy can be conducted from the energy source to the ablator to create a footprint on the target tissue to reduce an overall mass of excitable tissue.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0014]
    FIG. 1 is an illustration of a posteroinferior view of the human heart removed from the chest cavity.
  • [0015]
    FIG. 2 is an illustration of a cross-section of the human heart showing the left atrium and the ostia leading to the pulmonary veins.
  • [0016]
    FIG. 3 is a schematic illustration of an ablation apparatus according to one embodiment of the invention shown being applied to a patient.
  • [0017]
    FIG. 4 is a top view of an ablation apparatus according to another embodiment of the invention with an ablator on an insulated balloon.
  • [0018]
    FIG. 4A is a cross-sectional view along the line 4A-4A of FIG. 4.
  • [0019]
    FIG. 4B is a partial perspective view of a distal end of an insertion tool having the ablator of FIG. 4 removably inserted therein.
  • [0020]
    FIG. 5 is a top view of an ablation apparatus according to another embodiment of the invention with an ablator as a patch.
  • [0021]
    FIG. 5A is a cross-sectional view of the ablation apparatus along line 5A-5A of FIG. 5.
  • [0022]
    FIG. 6 is a top view of an ablation apparatus according to another embodiment of the invention with an ablator as a contoured patch.
  • [0023]
    FIG. 7 is a perspective view of an ablation apparatus according to another embodiment of the invention with an ablator as a bipolar electrode.
  • [0024]
    FIG. 8 is a perspective view of an ablation apparatus according to another embodiment of the invention with a suction tent having a wiper.
  • [0025]
    FIG. 9 is a perspective view of an ablation apparatus according to another embodiment of the invention with an ablator as an adhesive tongue electrode.
  • [0026]
    FIG. 10 is a perspective view of an ablation apparatus according to another embodiment of the invention with a head having a cauterizing chemical applicator.
  • [0027]
    FIG. 11 is a top view and an end view of an ablation apparatus according to another embodiment of the invention with a rolled electrode for insertion in a catheter or other delivery tool.
  • [0028]
    FIG. 12 is a side view of an ablation apparatus according to another embodiment of the invention with a web ablator.
  • [0029]
    FIGS. 13A and 13B are perspective views of an ablation apparatus according to another embodiment of the invention having an expandable mesh with electrodes.
  • [0030]
    FIG. 14 is a side view of an ablation apparatus according to another embodiment of the invention with a contoured ablator for ablating adjacent to the pulmonary veins.
  • [0031]
    FIG. 15 is a top view of an ablation apparatus according to another embodiment of the invention with an ablator as a contoured patch.
  • [0032]
    FIG. 16 is a top view of an ablation apparatus according to another embodiment of the invention with a rolled electrode for insertion in a catheter or other delivery tool.
  • DETAILED DESCRIPTION
  • [0033]
    Before any embodiments of the invention are explained in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of components set forth in the following description or illustrated in the following drawings. The invention is capable of other embodiments and of being practiced or of being carried out in various ways. Also, it is to be understood that the phraseology and terminology used herein is for the purpose of description and should not be regarded as limited. The use of “including,” “comprising” or “having” and variations thereof herein is meant to encompass the items listed thereafter and equivalents thereof as well as additional items. The terms “mounted,” “connected” and “coupled” are used broadly and encompass both direct and indirect mounting, connecting and coupling. Further, “connected” and “coupled” are not restricted to physical or mechanical connections or couplings, and can include electrical connections or couplings, whether direct or indirect.
  • [0034]
    Some embodiments of the invention provide a method and apparatus for reducing the mass of the viable tissue (e.g., by rendering the mass of tissue non-contractile, non-viable, or unable to propagate an action potential) in the left atrium of the heart to prevent or cure atrial fibrillation. Some embodiments of the invention can include preventing reentry of depolarizing wavefront signals by ablating a large area of the left atrium. Furthermore, some embodiments of the invention can substantially prevent the sustenance of atrial fibrillation.
  • [0035]
    Embodiments of the invention can provide an ablation apparatus used to conduct ablating energy to a locale of contacted or non-contacted and possibly surrounding tissue with the intent to ablate an entire area, while not harming neighboring tissue. The ablation apparatus can include an electrode having a footprint of a dimension designed to cover a predetermined region of tissue in the left atrium.
  • [0036]
    According to some embodiments of the invention, an ablation apparatus can be used to ablate a non-linear area of the tissue in the left atrium en masse. This method can be performed by endocardial positioning of an ablation device in the left atrium either via a trans-atrial septal puncture or retrograde through the arterial system. Alternatively, embodiments of the invention can provide a method of ablating tissue in the left atrium in a predefined area by inserting an ablating apparatus using an epicardial approach with access to the posterior left atrium through the pericardial space, either by a sub-xiphoid or inter-costal incision.
  • [0037]
    Some embodiments of the invention provide a method of ablating tissue using a large footprint ablation electrode for the control, prevention, and cure of atrial fibrillation. The method can include ablating a predefined area of tissue in the left atrium, while protecting other areas of the heart, lungs, and esophagus using directional energy delivery, insulation, or standoffs to space the ablation apparatus from protected areas. The method of ablating the heart tissue can include using a trans-venous catheter from the inside of the heart to deliver the ablation apparatus. Location and imaging techniques such as echogram, sonogram, magnetic resonance imaging, ultrasound, X-ray, sensors or transmitters on the ablation device, or other mapping technology can allow for proper placement to minimize damage to surrounding tissue.
  • [0038]
    Some embodiments of the invention include a locatable ablation apparatus having a predefined footprint that can be delivered through an incision in the chest wall in order to ablate by trans-myocardial engagement with a bipolar electrode. The ablation apparatus can use any of suitable method and/or procedure with electro-surgical devices or other types of ablation devices (e.g., thermal ablation, micro-wave ablation, cryogenic ablation, ultrasound ablation, etc.) to ablate tissue in the left atrium to reduce the mass of excitable tissue therein.
  • [0039]
    The apparatuses and methods of some embodiments of the invention are designed to reduce the overall excitable mass of the left atrium and to reduce or cure atrial fibrillation (AF). Some embodiments of the invention use radio frequency energy to create heat and ablate an area of tissue. However, other embodiments of the invention may include additional or alternative energy sources, such as microwave, cryogenic, ultrasound, laser, thermal, etc. Also, some embodiments of the invention can be used for creating ablation lesions in other areas of the heart, such as the ventricles.
  • [0040]
    FIG. 1 illustrates the human heart 10 from a posteroinferior view. The left atrium 12 includes an external surface 14 of an area target tissue 15, which includes the area of tissue to be ablated. In some embodiments, the target tissue 15 can be defined as the entire left atrial posterior wall tissue extending around, but not including, the pulmonary veins. As shown in FIG. 1, the target tissue 15 can be generally spaced from the pulmonary veins 16 to prevent damage to the pulmonary veins 16.
  • [0041]
    As shown in FIG. 2, an inner chamber 22 of the left atrium 12 includes an internal surface 24 of the target tissue 15. The pulmonary veins 16 themselves are generally not included in the target tissue 15 due to concern over vein stenosis. The internal surface 24 of the target tissue 15 may be defined as the entire left atrial posterior wall tissue extending into the ostial regions surrounding the pulmonary veins 16, but not extending over into the lumen of the pulmonary veins, extending to near the mitral valve annulus. There is interest in creating conduction block in the area between one or both of the right inferior pulmonary vein and the mitral valve annulus. Tissue to be protected can include all tissue in the patient not defined as the target tissue 15. Tissue to be protected can be isolated to prevent damage. The target tissue 15 can be spaced from the ostia of the pulmonary veins 16, but may extend to areas surrounding the pulmonary vein ostia as well.
  • [0042]
    FIG. 3 illustrates an ablation apparatus 30 according to one embodiment of the invention for ablating the target tissue 15. The ablation apparatus 30 can include or be used in conjunction with an insertion tool 32, such as a trocar, an endoscopy port, a catheter, etc. The insertion tool 32 can include a distal end 34 and a proximal end 36. The ablation apparatus 30 can also include a lumen 38 that can extend through the insertion tool 32 and can open at the distal end 34 and/or the proximal end 36 of the insertion tool 32. The ablation apparatus 30 can further include an ablator 43 that can extend from the distal end 34 of the insertion tool 32. The ablator 43 can be inserted in the lumen 38 for delivery through an incision 40 in the patient 42. A conductor 44 can extend through the lumen 38 to connect the ablator 43 to a power source 46. The power source 46 can be a source of ablation energy, such as radio frequency energy. Other forms of ablative methods and energy sources can be used with the ablator 43. Other forms of ablation techniques include, but are not limited to, microwave, ultrasound, heat, cyrogenic, radiation, and chemical ablation.
  • [0043]
    Proper positioning of the ablator 43 on the targeted tissue 15 can be performed by any suitable means, such as direct visualization, fluoroscopic X-ray visualization, ultrasound positron emission tomography, fluoroscopy, intra-cardiac echo, trans-esophageal echo, magnetic resonance imaging, computerized tomography, or by endoscopic imaging. As shown in FIG. 3, a mapping tool 48 can include a sensor 50 connected to a display 52 to represent or visualize the position of the ablator 43 with respect to the target tissue 15. An input device, such as a toggle stick 54 or a pointer pen 56, can be used to identify the target tissue 15 on the heart 10.
  • [0044]
    The ablator 34 can include a tissue engagement section 60 (as shown in FIGS. 4-6), which can include a footprint that allows the tissue engagement section 60 to ablate a predefined area with each energization.
  • [0045]
    As shown in FIG. 4, the ablator 43 can include a balloon 58 having a tissue engagement section 60 with a footprint for endocardial or epicardial application. The footprint can be of a size and shape to conform to the individual patient requirements. The balloon 58 may include an inflator tube 62 positioned in the insertion tool 32. The inflator tube 62 can be connected to an inflation source 64 for inflating the balloon 58 with air, CO2, saline, etc. An insulator 66 on the balloon 58 can protect adjacent tissue from the energy in the ablator 43, while ablating the target tissue 15 bearing against the footprint of the tissue engagement section 60. Additional insulation can be achieved by the saline or gas in the balloon 58. The insertion tool 32 can be flexible or rigid to help the surgeon manipulate the position of the balloon 58 to bring the tissue engagement section 60 in contact with the target tissue 15. The inflation source 64 can direct liquid or gas through the inflator tube 62 to inflate the balloon 58. The balloon 58 can expand to cause the tissue engagement section 60 to bear against the target tissue 15. In some embodiments, as shown in FIG. 4, bowing struts 67 can be deployed within the left atrium 12 to push the ablator 43 into contact with the left atrial posterior wall. When deployed in the pericardial space, the balloon 58 may be inflated to force contact of the tissue engagement section 60 with the epicardial target tissue 15.
  • [0046]
    In some embodiments, the balloon 58 can include a conducting surface that acts as a tissue engagement section 60. A collapsed balloon 58 can be inserted into the left atrium 12 or into the pericardial space surrounding the epicardial surface of the target tissue 15. In one embodiment, the balloon 58 can then be inflated with saline from the inflation source 64 and oriented such that a thermally-transmissive, tissue engagement section 60 of the balloon 58 can be positioned against the posterior left atrium and an insulated portion of the balloon 58 can be positioned against the anterior left atrium. The saline can be heated by electrical current supplied by power source 46 to a temperature between 50 degrees Celsius and 85 degrees Celsius, and in some embodiments, between 55 degrees Celsius and 65 degrees Celsius. At these temperatures, the cells in the target area 15 generally die without collagen shrinkage. Alternatively, the balloon 58 can be cooled with cryogenic technology to freeze the atrial tissue and ablate the target tissue 15. Generally, temperatures for cryogenic therapy must be less than negative 20 degrees Celsius to negative 40 degrees Celsius.
  • [0047]
    FIG. 4 illustrates a cross section of the balloon 58 with the insulator 66 surrounding the ablator 43. The ablator 43 can include one or more ablating elements 68 on the tissue engagement section 60 for transferring the energy of the power source 46 to the target tissue 15. Ablating elements 68 may comprise one or more electrodes, ultrasound transducers, microwave antennae, cryogenic elements, chemical elements and/or radioactive elements, for example. Insertion of the balloon 58 into the left atrium 12 allows the balloon 58 to be manipulated during inflation to bring the ablating elements 68 of the tissue engagement section 60 to bear against the target tissue 15 and to space the ablating elements 68 from the tissue to be protected. The insulator 66 can protect adjacent tissue not within the area of the target tissue 15.
  • [0048]
    The ablator 43 can be delivered to the desired location in the patient using the insertion tool 32, such as a catheter 70, as shown in FIG. 4B. The footprint of the ablator 43 can be configured for any patient anatomy and/or any ablation pattern desired. The collapsed balloon 58 of the ablator 43 can be removably inserted through the distal end 34 of the catheter 70, so that the conductor 44 extends through the insertion tool 32, as shown in FIG. 4B. The catheter 70 can be inserted into the patient 42 (as described with respect to FIG. 3) to position the distal end 34 adjacent the target tissue 15. The conductor 44 can be used to push the ablator 43 out of the lumen 38 to a position extending from the distal end 34, as shown in FIG. 4.
  • [0049]
    FIGS. 5 and 5A illustrate an embodiment of a circular ablator 43. In other embodiments, the ablator 43 can be elliptical, oval, etc. The circular ablator 43 can include a tissue engagement surface 60 and an outside skirt 72. The outside skirt 72 can be used as a stand-off to space the tissue engagement surface 60 from delicate tissue, such as the pulmonary veins 16. The circular ablator 43 can include one or more ablating elements 68 on the tissue engagement surface 60 and an insulation layer 66 on the opposite surface, as shown in FIG. 5A. The ablating elements 68 can be positioned in a helical or circular pattern. The outside skirt 72 can be constructed of a soft, heat-insulating material, such as silicone or other elastomeric material. The outside skirt 72 can include an outer edge 74 constructed of a resilient material to positively space the ablating elements 68 from the tissue to be protected.
  • [0050]
    The circular ablator 43 can be used epicardially by insertion within the pericardial space adjacent the posterior left atrium. In one embodiment, the circular ablator 43 can alternatively include an uncoiling spiral configuration. The uncoiling spiral can be positioned through a sheath 32, and when advanced beyond the sheath 32, can uncoil to take the desired shape. Pre-formed shape memory or superelastic alloys, such as NiTi, can be used to ensure that the spiral uncoils into the desired shape.
  • [0051]
    In another embodiment, two circular ablators 43 can be used in a bipolar arrangement. One ablator 43 can be on the external surface 14 of the target tissue 15 and another ablator 43 can be positioned on the internal surface 24 of the target tissue 15 in the left atrium 12. The bipolar circular ablator 43 can also be positioned using an uncoiling spiral configuration. The uncoiling spiral can be positioned through a sheath 32, and when advanced beyond the sheath 32, can uncoil to take the desired shape. Pre-formed shape memory or superelastic alloys, such as NiTi, can be used to ensure that the spiral uncoils into the desired shape.
  • [0052]
    FIGS. 6 and 15 illustrate two embodiments of a contoured patch ablator 43 having a predefined shape with contoured edges 76. The contoured edges 76 can bear against structures in the heart, such as the pulmonary veins 16, to position the tissue engagement surface 60 against the target tissue 15. As shown in FIG. 6, ablating elements 68 can be connected to a power source 46 by the conductor 44 extending through an insertion tool 32 for either epicardial or endocardial use.
  • [0053]
    FIG. 7 illustrates an ablator 43 having two ablating elements, a first ablating element 80 and a second ablating element 82. A conductor 44 may be used to connect the first and second ablating elements 80, 82 together or separately for individual control. In one embodiment, ablating elements 80, 82 may comprise electrodes, which can be energized using radio frequency energy. Ablating elements 80, 82 may be held in contact with tissue by a vacuum applied to ports 83. Alternatively, the first ablating element 80 may be a high intensity focused ultrasound (HIFU) crystal transmitter or transducer and the second ablating element 82 can be another HIFU crystal transmitter or transducer, both of which can focus ultrasound energy on the target tissue 15. Alternatively, the first and second ablating elements 80, 82 may be microwave antennae, which can deliver microwave ablation energy to the target tissue 15. The ablator 43 may be used, in some embodiments, from a location within the esophagus to focus ablation energy on the posterior left atrium of the heart.
  • [0054]
    FIG. 8 illustrates an ablator 43 having a skirt 73 and a deployable wiper 86 that can be placed in the patient to surround the target tissue 15. The skirt 73 can be held to the target tissue 15 by a vacuum applied to a suction chamber 84. The deployable wiper 86 can be connected to a conductor 44 and can move within the skirt 73 of the ablator 43 to rotate in an arc around a pivot point (e.g., a motor 88). The deployable wiper 86 may include one or more ablating elements. The deployable wiper 86 can sweep from side to side and/or can rotate 360 degrees and can apply energy to ablate during all or during a portion of the rotation. The skirt 73 can be collapsible to be removably inserted in a catheter 70. A resilient outer edge 74 can releasably seal onto the target tissue 15 when the vacuum is applied. An air gap between the skirt 73 and the deployable wiper 86 can protect adjacent tissue from harm by the ablation energy. Also, to aid in guiding the ablations within the skirt 73, a lumen can be provided adjacent to the conductor 44 to allow passage of a fiber optic or endoscopic catheter, which can provide visual confirmation of proper positioning of the skirt 73 and of the selected region for ablation.
  • [0055]
    FIG. 9 illustrates an ablator 43 including an adhesive tongue 90 having a footprint extending from a catheter 70. A skirt 72 can be used to ablate tissue within an outer edge 74. The adhesive tongue 90 can be removably attached to the target tissue 15 for directed ablation by a vacuum applied through a conductor 44. In other embodiments, contact may be facilitated with a biological compatible glue or adhesive 91 on a tissue engagement surface 60. A conductive fluid 92 can be used in a chamber 84 of the skirt 72 to translate the ablating energy to all tissue within the outer edge 74. Alternatively, epicardial application of the adhesive tongue 90 with slow release ablation chemicals can be used to ablate tissue. The adhesive tongue 90 can also include, in some embodiments, anti-arrhythmia medications or other medications.
  • [0056]
    FIG. 10 illustrates an ablator 43 designed to deliver one or more ablation agents, e.g., chemical ablation agents and/or radioactive ablation agents. A conductor or conduit 44 can transfer an ablative agent through a tip 96 to come in contact with tissue within an outer edge 74 of a skirt 72. The tip 96 can be removably inserted into a catheter 70 to be positioned in the left atrium. The catheter 70 can be manipulated and rotated to cause the skirt 72 to cover the target tissue 15. An ablation agent can be introduced into a chamber 84 within the shirt 72 to ablate the target tissue 15. Following the ablation procedure, any remaining ablation agent may be removed back through tip 96. In some embodiments, tip 96 may be designed for mechanical injection and/or needle-less injection of an ablation agent into tissue. In one embodiment, the ablation agent diffuses into the tissue to be treated. Alternatively, the ablation agent is delivered via controlled slow-release delivery and/or iontophoresis techniques.
  • [0057]
    FIG. 11 illustrates an ablator 43 including a rolled ablating element 98 that can be rolled into a single roll or parallel rolls and can be removably inserted in an insertion tool 32. S-shaped memory wires 100 can unroll the rolled ablating element 98 when a conductor 44 urges the rolled ablating element 98 out of a lumen 38. The rolled ablating element 98 can be rolled for placement between the heart 10 and pericardium for epicardial ablation onto the external surface 14 of the target tissue 15. The rolled ablating element 98 can be similar to the circular and contoured embodiments shown in FIGS. 5 and 6, respectively.
  • [0058]
    FIG. 12 illustrates an ablator 43 including a webbed fan 102 having ablating elements 68 a and 68 b positioned in an apex 104 of each fold 106. The ablating elements 68 a when positioned adjacent the target tissue 15 can be energized and the ablating elements 68 b spaced from the target tissue 15 can remain non-energized to protect tissue outside the area of target tissue 15. The webbed fan 102 can include an insulation layer on one side. The webbed fan 102 can be unfolded into a flat sheet to energize all or a portion of the ablating elements 68 a, 68 b. The webbed fan 102 may be compressed to be removably inserted in a lumen 38 of a catheter 70.
  • [0059]
    FIGS. 13A and 13B illustrate an ablator 43 with an expandable mesh with numerous ablating elements 68. The ablator 43 can be positioned in the left atrium using an insertion tool 32. Each ablating element 68 can be individually represented using a mapping tool 48 and displayed on a display 52. A conductor 44 can allow individual electrodes 68 in contact with the target tissue 15 to be energized by a power source 46 to ablate tissue. One or more sensors 50 can be positioned inside the expandable mesh to locate the target tissue 15. The ablating elements 68 on the expandable mesh that are contacting the posterior left atrium can be selected. Selection can be facilitated by electrophysiological mapping, computerized complex algorithms, imaging, individual addressing of smart ablating elements 68, or other suitable methods. The appropriate ablating elements 68 can be are energized either individually or collectively to create an area of ablated tissue on the posterior.
  • [0060]
    FIG. 14 illustrates a contoured ablator 43 with a predefined shape defined by contoured edges 76. The contoured edges 76 can bear against structures on the heart, such as the pulmonary veins 16 to position a tissue engagement surface 60 against the target tissue 15. One or more ablating elements 68 can be connected to a power source (not shown) by a conductor 44.
  • [0061]
    FIG. 16 illustrates a coiled linear ablator 43 with one or more coiled ablating elements that can be deployed out of an insertion tool 32 (e.g., a sheath) to create an area for ablation. In some embodiments, the coiled linear ablator 43 can deliver energy in one direction (e.g., toward the epicardial surface of the posterior left atrium).
  • [0062]
    In some embodiments, the ablator 43 (e.g., an ablation energy transmitting member having one or more ablating elements) may be remote from the target tissue 15. For example, ultrasound energy may be focused remotely on the target tissue 15, causing ablation of the target tissue 15, while passing without ablating through non-targeted tissue located between the targeted tissue and ablator 43. The location of the energy focus on the target tissue 15 can be moved throughout the region to be ablated by steering a focal point about a non-linear area to be ablated. A steering mechanism can be manual (e.g., by physically moving an ultrasound transducer relative to the tissue) or electrical (e.g., by using phased arrays of ultrasound transducers or by otherwise modifying the ultrasound focal zone).
  • [0063]
    Some embodiments of the invention are effective at terminating atrial fibrillation, yet can be performed more safely than some conventional methods. Some embodiments of the invention can perform ablations more quickly than some conventional methods. Some embodiments of the invention can also be used to amputate, ligate, staple, etc. the left atrial appendage (LAA) of the heart—a major source of clots and strokes in the population. Some embodiments of the invention result in less trauma to the patient and less chance of accidentally damaging the heart and surrounding structures. Some embodiments of the invention can minimize the size of the incision required to insert the ablation apparatus 30 and/or the ablator 43 through the chest wall. Some embodiments of the invention can eliminate the need for contiguous, linear lesions to treat atrial fibrillation. Some embodiments of the invention can allow the surgeon to create lesions in the heart from the epicardial surface of the beating heart. Some embodiments of the invention can be practiced via transvenous catheters from the inside of the heart.
  • [0064]
    Various additional features and advantages of the invention are set forth in the following claims.

Claims (28)

  1. 1. A method of ablating target tissue including a non-linear area of tissue in a left atrium of a patient, the method comprising:
    selecting an ablation apparatus having an ablator with a tissue engagement section;
    penetrating a chest cavity of the patient;
    identifying the target tissue;
    positioning the ablation apparatus adjacent to the target tissue so that the tissue engagement section can transfer ablation energy to the target tissue; and
    energizing the tissue engagement section with ablation energy in order to create a footprint on the non-linear area of tissue in the left atrium and to reduce an overall mass of excitable tissue in the left atrium.
  2. 2. The method of claim 1 and further comprising choosing an ablation apparatus using at least one of radio frequency energy, thermal energy, cryogenic energy, chemical energy, pharmacological energy, ultrasound energy, microwave energy, laser energy, and radiation energy.
  3. 3. The method of claim 1 and further comprising choosing an ablation apparatus including at least one of a balloon, a mesh, a patch, a rolled electrode, a fan, a bipolar electrode, a wiper, and a crystal transmitter.
  4. 4. The method of claim 1 and further comprising penetrating the chest cavity by entering through at least one of a sub-xiphoid incision, a sub-costal incision, a sternotomy, a thoracotomy, and a trans-venous puncture.
  5. 5. The method of claim 1 and further comprising identifying the target tissue using at least one of direct visualization, X-ray, ultrasound, magnetic resonance imaging, positron emission tomography, computerized tomography, fluoroscopy, endoscopic observation, intra cardiac echo, and transesophageal echo.
  6. 6. The method of claim 1 and further comprising placing the ablation apparatus adjacent the outside of the left atrium by an epicardial approach.
  7. 7. The method of claim 1 and further comprising placing the ablation apparatus adjacent the inside of the left atrium by an endocardial approach.
  8. 8. The method of claim 1 and further comprising placing the ablation apparatus adjacent the left atrium by a transesophageal approach.
  9. 9. The method of claim 8 and further comprising energizing the tissue engagement section with ultrasound energy.
  10. 10. The method of claim 9 and further comprising focusing the ultrasound energy on the target tissue.
  11. 11. The method of claim 1 and further comprising transferring energy to a portion of the ablation apparatus at the tissue engagement section.
  12. 12. The method of claim 1 and further comprising:
    removably placing the ablation apparatus in a delivery end of an insertion tool;
    positioning the insertion tool into the patient through an incision;
    directing the delivery end to a location adjacent the target tissue;
    removing the ablation apparatus from the insertion tool; and
    adjusting the ablation apparatus to bring the tissue engagement section in contact with the target tissue.
  13. 13. The method of claim 1 and further comprising affixing the tissue engagement section to the target tissue by at least one of a bio-adhesive, a vacuum, an inflatable balloon, a mechanical deflection, a magnetic field, a shape memory alloy, and a superelastic alloy.
  14. 14. The method of claim 1 and further comprising providing an insulator in the ablation apparatus to prevent damage to tissue adjacent the target tissue.
  15. 15. An ablation apparatus for ablating target tissue of a patient, the ablation apparatus comprising:
    an insertion tool having a proximal end, a distal end, and a lumen;
    an ablator including a conductor and a tissue engagement portion, the conductor having a source end extending from the proximal end of the insertion tool and a delivery end coupled to the tissue engagement portion, the ablator removably inserted in the lumen; and
    an energy source connected to the conductor;
    the insertion tool being inserted into a patient so that the distal end is adjacent the target tissue, the conductor urging the ablator out of the lumen to engage the target tissue;
    energy being conducted from the energy source to the ablator to create a footprint on the target tissue to reduce an overall mass of excitable tissue.
  16. 16. The ablation apparatus of claim 15 and further comprising a sensor connected to the ablator to sense the target tissue.
  17. 17. The ablation apparatus of claim 15 and further comprising a mapping tool to visualize the tissue engagement portion of the ablator.
  18. 18. The ablation apparatus of claim 15 wherein the insertion tool includes a catheter.
  19. 19. The ablation apparatus of claim 15 wherein the ablator includes a patch removably attachable to the target tissue, the patch including at least one of an adhesive patch, a tongue patch, a circular patch, a balloon patch, a suction patch, a chemical release patch, a rolled patch, a carbon patch, and a webbed patch.
  20. 20. The ablation apparatus of claim 15 wherein the ablator includes a skirt that can suction to the target tissue, the skirt receiving fluid for conducting the energy to the target tissue.
  21. 21. The ablation apparatus of claim 20 wherein the fluid is electrically conductive.
  22. 22. The ablation apparatus of claim 20 wherein the fluid is caustic.
  23. 23. The ablation apparatus of claim 20 wherein the fluid is thermally conductive.
  24. 24. The ablation apparatus of claim 15 wherein the ablator includes a balloon, the balloon being inflatable to occupy a cavity in the patient adjacent to the target tissue, the balloon being removably stored in the distal end of the insertion tool wherein the balloon is inflated causing the balloon to emerge from the insertion tool, and the balloon being positionable to cause the tissue engagement portion to bear against the target tissue.
  25. 25. The ablation apparatus of claim 15 wherein the ablator includes a chemical delivery system.
  26. 26. The ablation apparatus of claim 25 wherein the chemical delivery system includes a delivery method of at least one of diffusion, iontophoresis, mechanical injection, needle-less injection, and controlled slow-release delivery.
  27. 27. The ablation apparatus of claim 15 wherein the ablator includes a skirt and an adhesive tongue inside the skirt, the tongue moveable within the skirt to engage the target tissue, the skirt affixing the ablator to the target tissue by a vacuum.
  28. 28. The ablation apparatus of claim 15 wherein the tissue engagement portion includes a first bipolar tissue electrode and a second bipolar tissue electrode, wherein the first bipolar tissue electrode is applied to the interior of the left atrium endocardially, wherein the second bipolar tissue electrode is applied to the exterior of the left atrium epicardially, each of the first and second bipolar tissue electrodes connected to the energy source, energy being applied from the energy source to conduct from the first bipolar tissue electrode to the second bipolar tissue electrode to render a mass of left atrium tissue located between the first and second bipolar tissue electrodes at least one of non-contractile, non-viable, and unable to propagate an action potential.
US11128786 2004-05-14 2005-05-13 Method and devices for treating atrial fibrillation by mass ablation Abandoned US20060009756A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US57118204 true 2004-05-14 2004-05-14
US11128786 US20060009756A1 (en) 2004-05-14 2005-05-13 Method and devices for treating atrial fibrillation by mass ablation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11128786 US20060009756A1 (en) 2004-05-14 2005-05-13 Method and devices for treating atrial fibrillation by mass ablation
US13584932 US8801707B2 (en) 2004-05-14 2012-08-14 Method and devices for treating atrial fibrillation by mass ablation
US14321121 US20150005694A1 (en) 2004-05-14 2014-07-01 Method and Devices for Treating Atrial Fibrillation by Mass Ablation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13584932 Division US8801707B2 (en) 2004-05-14 2012-08-14 Method and devices for treating atrial fibrillation by mass ablation

Publications (1)

Publication Number Publication Date
US20060009756A1 true true US20060009756A1 (en) 2006-01-12

Family

ID=34969568

Family Applications (3)

Application Number Title Priority Date Filing Date
US11128786 Abandoned US20060009756A1 (en) 2004-05-14 2005-05-13 Method and devices for treating atrial fibrillation by mass ablation
US13584932 Active 2025-06-14 US8801707B2 (en) 2004-05-14 2012-08-14 Method and devices for treating atrial fibrillation by mass ablation
US14321121 Abandoned US20150005694A1 (en) 2004-05-14 2014-07-01 Method and Devices for Treating Atrial Fibrillation by Mass Ablation

Family Applications After (2)

Application Number Title Priority Date Filing Date
US13584932 Active 2025-06-14 US8801707B2 (en) 2004-05-14 2012-08-14 Method and devices for treating atrial fibrillation by mass ablation
US14321121 Abandoned US20150005694A1 (en) 2004-05-14 2014-07-01 Method and Devices for Treating Atrial Fibrillation by Mass Ablation

Country Status (6)

Country Link
US (3) US20060009756A1 (en)
EP (1) EP1750605B1 (en)
JP (1) JP2007537011A (en)
CA (1) CA2569701A1 (en)
ES (1) ES2308505T3 (en)
WO (1) WO2005112812A1 (en)

Cited By (108)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030191462A1 (en) * 1996-05-03 2003-10-09 Jacobs Clemens J. Method for interrupting conduction paths within the heart
US20040015219A1 (en) * 2002-05-16 2004-01-22 Francischelli David E. Device and method for ablation of cardiac tissue
US20040015106A1 (en) * 2000-01-19 2004-01-22 Coleman R. Glen Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US20040049179A1 (en) * 2001-04-26 2004-03-11 Francischelli David E. Ablation system
US20040078069A1 (en) * 2001-12-11 2004-04-22 Francischelli David E. Method and system for treatment of atrial tachyarrhythmias
US20040138621A1 (en) * 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US20040138656A1 (en) * 2000-04-27 2004-07-15 Francischelli David E. System and method for assessing transmurality of ablation lesions
US20040215183A1 (en) * 1995-02-22 2004-10-28 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US20040220560A1 (en) * 2003-04-29 2004-11-04 Briscoe Roderick E. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US20040236322A1 (en) * 1997-07-18 2004-11-25 Mulier Peter M.J. Device and method for ablating tissue
US20050033280A1 (en) * 2001-04-26 2005-02-10 Francischelli David E. Method and system for treatment of atrial tachyarrhythmias
US20050165392A1 (en) * 2002-01-25 2005-07-28 Medtronic, Inc. System and method of performing an electrosurgical procedure
US20050209564A1 (en) * 2001-01-13 2005-09-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20050256522A1 (en) * 2004-05-12 2005-11-17 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
US20050267454A1 (en) * 2000-01-19 2005-12-01 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20050273006A1 (en) * 2000-10-10 2005-12-08 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US20060009759A1 (en) * 2004-06-02 2006-01-12 Chrisitian Steven C Loop ablation apparatus and method
US20060009760A1 (en) * 1998-07-07 2006-01-12 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US20060020263A1 (en) * 2004-06-02 2006-01-26 Rothstein Paul T Clamping ablation tool and method
US20060020271A1 (en) * 2004-06-18 2006-01-26 Stewart Mark T Methods and devices for occlusion of an atrial appendage
US20060036236A1 (en) * 2004-06-02 2006-02-16 Rothstein Paul T Compound bipolar ablation device and method
US20060041254A1 (en) * 2002-10-30 2006-02-23 Medtronic, Inc. Electrosurgical hemostat
US20060041243A1 (en) * 2001-01-13 2006-02-23 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20060047278A1 (en) * 2004-06-02 2006-03-02 Christian Steven C Ablation device with jaws
US20060052770A1 (en) * 1998-07-07 2006-03-09 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US20060195082A1 (en) * 2001-04-26 2006-08-31 Francischelli David E Method and apparatus for tissue ablation
US20060229594A1 (en) * 2000-01-19 2006-10-12 Medtronic, Inc. Method for guiding a medical device
US20070049920A1 (en) * 2000-03-06 2007-03-01 Tissuelink Medical, Inc. Fluid-Assisted Medical Devices, Fluid Delivery Systems and Controllers for Such Devices, and Methods
US20070049923A1 (en) * 2002-05-16 2007-03-01 Jahns Scott E Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US20070118107A1 (en) * 2000-04-27 2007-05-24 Francischelli David E Vibration sensitive ablation device and method
US20070156127A1 (en) * 2005-12-29 2007-07-05 Boston Scientific Scimed, Inc. Foam electrode and method of use thereof during tissue resection
US20070203484A1 (en) * 2006-01-27 2007-08-30 David Kim Methods of using ablation device and of guiding ablation device into body
US20070208332A1 (en) * 1995-02-22 2007-09-06 Mulier Peter M Pen-type electrosurgical instrument
US20070270688A1 (en) * 2006-05-19 2007-11-22 Daniel Gelbart Automatic atherectomy system
US20080004534A1 (en) * 2006-06-28 2008-01-03 Daniel Gelbart Intra-cardiac mapping and ablation method
US20080009851A1 (en) * 2006-06-28 2008-01-10 Dan Wittenberger Variable geometry cooling chamber
US20080039746A1 (en) * 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
WO2008082494A2 (en) * 2006-12-20 2008-07-10 The Trustees Of The University Of Pennsylvania Esophagial visualization device
US20080275439A1 (en) * 2002-01-25 2008-11-06 David Francischelli Cardiac ablation and electrical interface system and instrument
US20090131930A1 (en) * 2007-11-16 2009-05-21 Daniel Gelbart Medical device for use in bodily lumens, for example an atrium
US20090171346A1 (en) * 2007-12-28 2009-07-02 Greg Leyh High conductivity inductively equalized electrodes and methods
US20090192441A1 (en) * 2008-01-25 2009-07-30 Daniel Gelbart Liposuction system
US20090222001A1 (en) * 2007-12-28 2009-09-03 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Devices, Methods and Systems
US20090306647A1 (en) * 2008-06-05 2009-12-10 Greg Leyh Dynamically controllable multi-electrode apparatus & methods
US20100022999A1 (en) * 2008-07-24 2010-01-28 Gollnick David A Symmetrical rf electrosurgical system and methods
US20100042110A1 (en) * 2004-06-18 2010-02-18 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US20100114089A1 (en) * 2008-10-21 2010-05-06 Hermes Innovations Llc Endometrial ablation devices and systems
US20100145361A1 (en) * 2004-06-18 2010-06-10 Francischelli David E Methods and Devices for Occlusion of an Atrial Appendage
US20100145331A1 (en) * 2004-06-02 2010-06-10 Chrisitian Steven C Loop Ablation Apparatus and Method
US20100198216A1 (en) * 2009-02-02 2010-08-05 Palanker Daniel V Electro-thermotherapy of tissue using penetrating microelectrode array
US20100217255A1 (en) * 2009-02-23 2010-08-26 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Device and Methods of Use Thereof
US7818039B2 (en) 2000-04-27 2010-10-19 Medtronic, Inc. Suction stabilized epicardial ablation devices
US7824399B2 (en) 2001-04-26 2010-11-02 Medtronic, Inc. Ablation system and method of use
US20100312096A1 (en) * 2009-06-08 2010-12-09 Michael Guttman Mri-guided interventional systems that can track and generate dynamic visualizations of flexible intrabody devices in near real time
US20100317962A1 (en) * 2009-06-16 2010-12-16 Jenkins Kimble L MRI-Guided Devices and MRI-Guided Interventional Systems that can Track and Generate Dynamic Visualizations of the Devices in near Real Time
US20110022166A1 (en) * 2008-05-13 2011-01-27 Kardium Inc. Medical device for constricting tissue or a bodily orifice, for example a mitral valve
US20110112523A1 (en) * 2009-11-11 2011-05-12 Minerva Surgical, Inc. Systems, methods and devices for endometrial ablation utilizing radio frequency
US20110118718A1 (en) * 2009-11-13 2011-05-19 Minerva Surgical, Inc. Methods and systems for endometrial ablation utilizing radio frequency
US20110125146A1 (en) * 2009-09-08 2011-05-26 Salient Surgical Technologies, Inc. Cartridge Assembly For Electrosurgical Devices, Electrosurgical Unit And Methods Of Use Thereof
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US8096959B2 (en) 2001-05-21 2012-01-17 Medtronic, Inc. Trans-septal catheter with retention mechanism
US8172835B2 (en) 2008-06-05 2012-05-08 Cutera, Inc. Subcutaneous electric field distribution system and methods
US20120123403A1 (en) * 2010-11-12 2012-05-17 Vivant Medical, Inc. Apparatus, System and Method for Performing an Electrosurgical Procedure
US8197477B2 (en) 2008-10-21 2012-06-12 Hermes Innovations Llc Tissue ablation methods
US8197476B2 (en) 2008-10-21 2012-06-12 Hermes Innovations Llc Tissue ablation systems
US8372068B2 (en) 2008-10-21 2013-02-12 Hermes Innovations, LLC Tissue ablation systems
US20130066308A1 (en) * 2011-08-31 2013-03-14 Jaime Landman Ablation-based therapy for bladder pathologies
US8529562B2 (en) 2009-11-13 2013-09-10 Minerva Surgical, Inc Systems and methods for endometrial ablation
US8540708B2 (en) 2008-10-21 2013-09-24 Hermes Innovations Llc Endometrial ablation method
US8568409B2 (en) 2000-03-06 2013-10-29 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US8663245B2 (en) 2004-06-18 2014-03-04 Medtronic, Inc. Device for occlusion of a left atrial appendage
US8801707B2 (en) 2004-05-14 2014-08-12 Medtronic, Inc. Method and devices for treating atrial fibrillation by mass ablation
US8821486B2 (en) 2009-11-13 2014-09-02 Hermes Innovations, LLC Tissue ablation systems and methods
US8870864B2 (en) 2011-10-28 2014-10-28 Medtronic Advanced Energy Llc Single instrument electrosurgery apparatus and its method of use
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
US8920417B2 (en) 2010-06-30 2014-12-30 Medtronic Advanced Energy Llc Electrosurgical devices and methods of use thereof
US8940002B2 (en) 2010-09-30 2015-01-27 Kardium Inc. Tissue anchor system
US8956348B2 (en) 2010-07-21 2015-02-17 Minerva Surgical, Inc. Methods and systems for endometrial ablation
US20150066016A1 (en) * 2013-09-05 2015-03-05 Mitragen, Inc. Valve treatment devices, systems, and methods
US9011423B2 (en) 2012-05-21 2015-04-21 Kardium, Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US9023040B2 (en) 2010-10-26 2015-05-05 Medtronic Advanced Energy Llc Electrosurgical cutting devices
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
US9119633B2 (en) 2006-06-28 2015-09-01 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US9138289B2 (en) 2010-06-28 2015-09-22 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US9192468B2 (en) 2006-06-28 2015-11-24 Kardium Inc. Method for anchoring a mitral valve
US9198592B2 (en) 2012-05-21 2015-12-01 Kardium Inc. Systems and methods for activating transducers
US9204964B2 (en) 2009-10-01 2015-12-08 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
US9226792B2 (en) 2012-06-12 2016-01-05 Medtronic Advanced Energy Llc Debridement device and method
US9333027B2 (en) * 2010-05-28 2016-05-10 Medtronic Advanced Energy Llc Method of producing an electrosurgical device
US9381061B2 (en) 2000-03-06 2016-07-05 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US9427281B2 (en) 2011-03-11 2016-08-30 Medtronic Advanced Energy Llc Bronchoscope-compatible catheter provided with electrosurgical device
US9452016B2 (en) 2011-01-21 2016-09-27 Kardium Inc. Catheter system
US9480525B2 (en) 2011-01-21 2016-11-01 Kardium, Inc. High-density electrode-based medical device system
US9486281B2 (en) 2010-04-13 2016-11-08 Sentreheart, Inc. Methods and devices for accessing and delivering devices to a heart
US9492227B2 (en) 2011-01-21 2016-11-15 Kardium Inc. Enhanced medical device for use in bodily cavities, for example an atrium
US9510897B2 (en) 2010-11-05 2016-12-06 Hermes Innovations Llc RF-electrode surface and method of fabrication
USD777925S1 (en) 2012-01-20 2017-01-31 Kardium Inc. Intra-cardiac procedure device
USD777926S1 (en) 2012-01-20 2017-01-31 Kardium Inc. Intra-cardiac procedure device
US9572557B2 (en) 2006-02-21 2017-02-21 Kardium Inc. Method and device for closing holes in tissue
US9592090B2 (en) 2010-03-11 2017-03-14 Medtronic Advanced Energy Llc Bipolar electrosurgical cutter with position insensitive return electrode contact
US20170087372A1 (en) * 2007-04-23 2017-03-30 Plasmology4, Inc. Cold Plasma Electroporation of Medication and Associated Methods
US9649125B2 (en) 2013-10-15 2017-05-16 Hermes Innovations Llc Laparoscopic device
US9662163B2 (en) 2008-10-21 2017-05-30 Hermes Innovations Llc Endometrial ablation devices and systems
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
US9901394B2 (en) 2013-04-04 2018-02-27 Hermes Innovations Llc Medical ablation system and method of making
US9931134B2 (en) 2017-07-05 2018-04-03 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9055942B2 (en) * 2005-10-03 2015-06-16 Boston Scienctific Scimed, Inc. Endoscopic plication devices and methods
GB0620061D0 (en) 2006-10-10 2006-11-22 Medical Device Innovations Ltd Oesophageal treatment apparatus and method
CN101563043B (en) * 2006-11-28 2013-03-27 皇家飞利浦电子股份有限公司 Apparatus, method and computer program for applying energy to an object
US20080188714A1 (en) * 2007-02-07 2008-08-07 Boston Scientific Scimed, Inc. Electromechanical in-situ cleaning of optical elements
WO2013126489A1 (en) * 2012-02-24 2013-08-29 Isolase, Ltd. Improvements in ablation techniques for the treatment of atrial fibrillation
US9743972B2 (en) 2014-07-18 2017-08-29 Medtronic Cryocath Lp Cardiac cryolipolysis for the treatment of cardiac arrhythmia

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3807403A (en) * 1972-06-14 1974-04-30 Frigitronics Of Conn Inc Cryosurgical apparatus
US3859986A (en) * 1973-06-20 1975-01-14 Jiro Okada Surgical device
US3862627A (en) * 1973-08-16 1975-01-28 Sr Wendel J Hans Suction electrode
US4018227A (en) * 1975-10-09 1977-04-19 Cryomedics, Inc. Cryosurgical instrument
US4072152A (en) * 1976-02-23 1978-02-07 Linehan John H Orthopedic cryosurgical apparatus
US4082096A (en) * 1973-12-10 1978-04-04 Benson Jerrel W Cryosurgical system
US4248224A (en) * 1978-08-01 1981-02-03 Jones James W Double venous cannula
US4377168A (en) * 1981-02-27 1983-03-22 Wallach Surgical Instruments, Inc. Cryosurgical instrument
US4562900A (en) * 1984-12-20 1986-01-07 Varian Associates, Inc. Lens system for acoustic transducer array
US4736749A (en) * 1985-04-26 1988-04-12 Astra-Tech Aktiebolag Holder for medical use fixed by vacuum
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US4815470A (en) * 1987-11-13 1989-03-28 Advanced Diagnostic Medical Systems, Inc. Inflatable sheath for ultrasound probe
US4916922A (en) * 1989-05-09 1990-04-17 Mullens Patrick L Rapid freezing apparatus
US4917095A (en) * 1985-11-18 1990-04-17 Indianapolis Center For Advanced Research, Inc. Ultrasound location and therapy method and apparatus for calculi in the body
US5078713A (en) * 1988-12-01 1992-01-07 Spembly Medical Limited Cryosurgical probe
US5080102A (en) * 1983-12-14 1992-01-14 Edap International, S.A. Examining, localizing and treatment with ultrasound
US5080660A (en) * 1990-05-11 1992-01-14 Applied Urology, Inc. Electrosurgical electrode
US5100388A (en) * 1989-09-15 1992-03-31 Interventional Thermodynamics, Inc. Method and device for thermal ablation of hollow body organs
US5108390A (en) * 1988-11-14 1992-04-28 Frigitronics, Inc. Flexible cryoprobe
US5178133A (en) * 1991-03-26 1993-01-12 Pena Louis T Laparoscopic retractor and sheath
US5275595A (en) * 1992-07-06 1994-01-04 Dobak Iii John D Cryosurgical instrument
US5277201A (en) * 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5281213A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Catheter for ice mapping and ablation
US5281215A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Cryogenic catheter
US5295484A (en) * 1992-05-19 1994-03-22 Arizona Board Of Regents For And On Behalf Of The University Of Arizona Apparatus and method for intra-cardiac ablation of arrhythmias
US5385148A (en) * 1993-07-30 1995-01-31 The Regents Of The University Of California Cardiac imaging and ablation catheter
US5397304A (en) * 1992-04-10 1995-03-14 Medtronic Cardiorhythm Shapable handle for steerable electrode catheter
US5396887A (en) * 1993-09-23 1995-03-14 Cardiac Pathways Corporation Apparatus and method for detecting contact pressure
US5400783A (en) * 1993-10-12 1995-03-28 Cardiac Pathways Corporation Endocardial mapping apparatus with rotatable arm and method
US5400770A (en) * 1992-01-15 1995-03-28 Nakao; Naomi L. Device utilizable with endoscope and related method
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US5402792A (en) * 1993-03-30 1995-04-04 Shimadzu Corporation Ultrasonic medical apparatus
US5403309A (en) * 1992-07-31 1995-04-04 Spembly Medical Limited Cryosurgical ablation
US5405376A (en) * 1993-08-27 1995-04-11 Medtronic, Inc. Method and apparatus for ablation
US5409483A (en) * 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5487757A (en) * 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5487385A (en) * 1993-12-03 1996-01-30 Avitall; Boaz Atrial mapping and ablation catheter system
US5496312A (en) * 1993-10-07 1996-03-05 Valleylab Inc. Impedance and temperature generator control
US5498248A (en) * 1992-11-12 1996-03-12 Implemed, Inc. Iontophoretic structure for medical devices
US5497774A (en) * 1993-11-03 1996-03-12 Daig Corporation Guiding introducer for left atrium
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5505730A (en) * 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US5590657A (en) * 1995-11-06 1997-01-07 The Regents Of The University Of Michigan Phased array ultrasound system and method for cardiac ablation
US5595183A (en) * 1995-02-17 1997-01-21 Ep Technologies, Inc. Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes
US5607462A (en) * 1993-09-24 1997-03-04 Cardiac Pathways Corporation Catheter assembly, catheter and multi-catheter introducer for use therewith
US5617854A (en) * 1994-06-22 1997-04-08 Munsif; Anand Shaped catheter device and method
US5713942A (en) * 1992-05-01 1998-02-03 Vesta Medical, Inc. Body cavity ablation apparatus and model
US5716389A (en) * 1995-11-13 1998-02-10 Walinsky; Paul Cardiac ablation catheter arrangement with movable guidewire
US5718241A (en) * 1995-06-07 1998-02-17 Biosense, Inc. Apparatus and method for treating cardiac arrhythmias with no discrete target
US5718701A (en) * 1993-08-11 1998-02-17 Electro-Catheter Corporation Ablation electrode
US5720775A (en) * 1996-07-31 1998-02-24 Cordis Corporation Percutaneous atrial line ablation catheter
US5722402A (en) * 1994-10-11 1998-03-03 Ep Technologies, Inc. Systems and methods for guiding movable electrode elements within multiple-electrode structures
US5730127A (en) * 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
US5730074A (en) * 1996-06-07 1998-03-24 Farmer Fabrications, Inc. Liquid dispenser for seed planter
US5730704A (en) * 1992-02-24 1998-03-24 Avitall; Boaz Loop electrode array mapping and ablation catheter for cardiac chambers
US5733280A (en) * 1995-11-15 1998-03-31 Avitall; Boaz Cryogenic epicardial mapping and ablation
US5735280A (en) * 1995-05-02 1998-04-07 Heart Rhythm Technologies, Inc. Ultrasound energy delivery system and method
US5735290A (en) * 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
US5871525A (en) * 1992-04-13 1999-02-16 Ep Technologies, Inc. Steerable ablation catheter system
US5871523A (en) * 1993-10-15 1999-02-16 Ep Technologies, Inc. Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5873845A (en) * 1997-03-17 1999-02-23 General Electric Company Ultrasound transducer with focused ultrasound refraction plate
US5876399A (en) * 1997-05-28 1999-03-02 Irvine Biomedical, Inc. Catheter system and methods thereof
US5879296A (en) * 1993-11-03 1999-03-09 Daig Corporation Guiding introducers for use in the treatment of left ventricular tachycardia
US5879295A (en) * 1997-04-02 1999-03-09 Medtronic, Inc. Enhanced contact steerable bowing electrode catheter assembly
US5881732A (en) * 1993-01-29 1999-03-16 Cardima, Inc. Intravascular method and system for treating arrhythmia
US5882346A (en) * 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5885278A (en) * 1994-10-07 1999-03-23 E.P. Technologies, Inc. Structures for deploying movable electrode elements
US5893848A (en) * 1996-10-24 1999-04-13 Plc Medical Systems, Inc. Gauging system for monitoring channel depth in percutaneous endocardial revascularization
US5895417A (en) * 1996-03-06 1999-04-20 Cardiac Pathways Corporation Deflectable loop design for a linear lesion ablation apparatus
US5897553A (en) * 1995-11-02 1999-04-27 Medtronic, Inc. Ball point fluid-assisted electrocautery device
US5897554A (en) * 1997-03-01 1999-04-27 Irvine Biomedical, Inc. Steerable catheter having a loop electrode
US6012457A (en) * 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6016811A (en) * 1998-09-01 2000-01-25 Fidus Medical Technology Corporation Method of using a microwave ablation catheter with a loop configuration
US6042556A (en) * 1998-09-04 2000-03-28 University Of Washington Method for determining phase advancement of transducer elements in high intensity focused ultrasound
US20020002372A1 (en) * 2000-04-27 2002-01-03 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6361531B1 (en) * 2000-01-21 2002-03-26 Medtronic Xomed, Inc. Focused ultrasound ablation devices having malleable handle shafts and methods of using the same
US6502575B1 (en) * 1996-05-03 2003-01-07 Clemens J. Jacobs Instrument for interrupting conduction paths within the heart
US6514250B1 (en) * 2000-04-27 2003-02-04 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6527767B2 (en) * 1998-05-20 2003-03-04 New England Medical Center Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization
US6537272B2 (en) * 1998-07-07 2003-03-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6537248B2 (en) * 1998-07-07 2003-03-25 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US20040015219A1 (en) * 2002-05-16 2004-01-22 Francischelli David E. Device and method for ablation of cardiac tissue
US20040015106A1 (en) * 2000-01-19 2004-01-22 Coleman R. Glen Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US6699240B2 (en) * 2001-04-26 2004-03-02 Medtronic, Inc. Method and apparatus for tissue ablation
US20040044340A1 (en) * 2001-04-26 2004-03-04 Francischelli David E. Ablation system and method of use
US6702811B2 (en) * 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US20040049179A1 (en) * 2001-04-26 2004-03-11 Francischelli David E. Ablation system
US6706038B2 (en) * 2000-04-27 2004-03-16 Medtronic, Inc. System and method for assessing transmurality of ablation lesions
US6706039B2 (en) * 1998-07-07 2004-03-16 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US20050010095A1 (en) * 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US6849073B2 (en) * 1998-07-07 2005-02-01 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US20050033280A1 (en) * 2001-04-26 2005-02-10 Francischelli David E. Method and system for treatment of atrial tachyarrhythmias
US6858028B2 (en) * 1997-07-29 2005-02-22 Medtronic, Inc. Tissue sealing electrosurgery device and methods of sealing tissue
US20060009759A1 (en) * 2004-06-02 2006-01-12 Chrisitian Steven C Loop ablation apparatus and method

Family Cites Families (217)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3823575A (en) 1971-06-07 1974-07-16 Univ Melbourne Cryogenic apparatus
US3736936A (en) 1971-12-13 1973-06-05 Hughes Aircraft Co Cryogenic heat transfer device
GB1438759A (en) 1972-06-02 1976-06-09 Spembly Ltd Cryo-surgical apparatus
US3886945A (en) 1972-06-14 1975-06-03 Frigitronics Of Conn Inc Cryosurgical apparatus
US3830239A (en) 1972-09-12 1974-08-20 Frigitronics Of Conn Inc Cryosurgical device
US3823718A (en) 1972-09-15 1974-07-16 T Tromovitch Portable cryosurgical apparatus
US3827436A (en) 1972-11-10 1974-08-06 Frigitronics Of Conn Inc Multipurpose cryosurgical probe
US3924628A (en) 1972-12-01 1975-12-09 William Droegemueller Cyrogenic bladder for necrosing tissue cells
DE2321089B2 (en) 1973-04-26 1976-12-30 Waermeisolierte, flexible line as coaxial double line
US3907339A (en) 1973-07-23 1975-09-23 Frigitronics Of Conn Inc Cryogenic delivery line
GB1513565A (en) 1975-04-22 1978-06-07 Spembly Ltd Cryosurgical instruments
GB1534162A (en) 1976-07-21 1978-11-29 Lloyd J Cyosurgical probe
US4061135A (en) 1976-09-27 1977-12-06 Jerrold Widran Binocular endoscope
US4275734A (en) 1977-08-12 1981-06-30 Valleylab, Inc. Cryosurgical apparatus and method
DE2831199C3 (en) 1978-07-15 1981-01-08 Erbe Elektromedizin Gmbh & Co Kg, 7400 Tuebingen
CA1129015A (en) 1980-06-11 1982-08-03 Timofei S. Gudkin Thermoelectric cryoprobe
US4598698A (en) 1983-01-20 1986-07-08 Warner-Lambert Technologies, Inc. Diagnostic device
US4601290A (en) 1983-10-11 1986-07-22 Cabot Medical Corporation Surgical instrument for cutting body tissue from a body area having a restricted space
GB2161082B (en) 1984-01-30 1986-12-03 Kh Nii Obschei Neot Khirurg Bipolar electric surgical instrument
US4664110A (en) 1985-03-18 1987-05-12 University Of Southern California Controlled rate freezing for cryorefractive surgery
US4872346A (en) 1986-07-18 1989-10-10 Indianapolis Center For Advanced Research Multiple frequencies from single crystal
US5231995A (en) 1986-11-14 1993-08-03 Desai Jawahar M Method for catheter mapping and ablation
US5044165A (en) 1986-12-03 1991-09-03 Board Of Regents, The University Of Texas Cryo-slammer
US4779611A (en) 1987-02-24 1988-10-25 Grooters Ronald K Disposable surgical scope guide
US5588432A (en) 1988-03-21 1996-12-31 Boston Scientific Corporation Catheters for imaging, sensing electrical potentials, and ablating tissue
US5029574A (en) 1988-04-14 1991-07-09 Okamoto Industries, Inc. Endoscopic balloon with a protective film thereon
US5147355A (en) 1988-09-23 1992-09-15 Brigham And Womens Hospital Cryoablation catheter and method of performing cryoablation
GB8829525D0 (en) 1988-12-17 1989-02-01 Spembly Medical Ltd Cryosurgical apparatus
US4936281A (en) 1989-04-13 1990-06-26 Everest Medical Corporation Ultrasonically enhanced RF ablation catheter
US4946460A (en) 1989-04-26 1990-08-07 Cryo Instruments, Inc. Apparatus for cryosurgery
US5516505A (en) 1989-07-18 1996-05-14 Mcdow; Ronald A. Method for using cryogenic agents for treating skin lesions
JPH03251240A (en) 1990-02-28 1991-11-08 Toshiba Corp Ultrasonic medical treatment device
GB9004427D0 (en) 1990-02-28 1990-04-25 Nat Res Dev Cryogenic cooling apparatus
US5013312A (en) 1990-03-19 1991-05-07 Everest Medical Corporation Bipolar scalpel for harvesting internal mammary artery
CA2091893A1 (en) 1990-09-26 1992-03-27 Boris Rubinsky Cryosurgical instrument and system and method of cryosurgery
US5269291A (en) 1990-12-10 1993-12-14 Coraje, Inc. Miniature ultrasonic transducer for plaque ablation
US5324255A (en) 1991-01-11 1994-06-28 Baxter International Inc. Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm
US5465717A (en) 1991-02-15 1995-11-14 Cardiac Pathways Corporation Apparatus and Method for ventricular mapping and ablation
US5316000A (en) 1991-03-05 1994-05-31 Technomed International (Societe Anonyme) Use of at least one composite piezoelectric transducer in the manufacture of an ultrasonic therapy apparatus for applying therapy, in a body zone, in particular to concretions, to tissue, or to bones, of a living being and method of ultrasonic therapy
US5341466A (en) 1991-05-09 1994-08-23 New York University Fractal computer user centerface with zooming capability
US5207674A (en) 1991-05-13 1993-05-04 Hamilton Archie C Electronic cryogenic surgical probe apparatus and method
WO1992020290A1 (en) 1991-05-17 1992-11-26 Innerdyne Medical, Inc. Method and device for thermal ablation
JP3307392B2 (en) 1991-05-29 2002-07-24 オリジン・メドシステムズ・インク Organ retraction device for endoscopic surgery
US5361752A (en) 1991-05-29 1994-11-08 Origin Medsystems, Inc. Retraction apparatus and methods for endoscopic surgery
US5370134A (en) 1991-05-29 1994-12-06 Orgin Medsystems, Inc. Method and apparatus for body structure manipulation and dissection
US5232516A (en) 1991-06-04 1993-08-03 Implemed, Inc. Thermoelectric device with recuperative heat exchangers
US5217860A (en) 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
US5520682A (en) 1991-09-06 1996-05-28 Cryomedical Sciences, Inc. Cryosurgical instrument with vent means and method using same
US5254116A (en) 1991-09-06 1993-10-19 Cryomedical Sciences, Inc. Cryosurgical instrument with vent holes and method using same
US5697882A (en) 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US5697281A (en) 1991-10-09 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US5217001A (en) 1991-12-09 1993-06-08 Nakao Naomi L Endoscope sheath and related method
US5228923A (en) 1991-12-13 1993-07-20 Implemed, Inc. Cylindrical thermoelectric cells
FR2685872A1 (en) 1992-01-07 1993-07-09 Edap Int An apparatus for extracorporeal ultrasound hyperthermia very great power, and process for its operation.
US5222501A (en) 1992-01-31 1993-06-29 Duke University Methods for the diagnosis and ablation treatment of ventricular tachycardia
US5263493A (en) 1992-02-24 1993-11-23 Boaz Avitall Deflectable loop electrode array mapping and ablation catheter for cardiac chambers
US5318525A (en) 1992-04-10 1994-06-07 Medtronic Cardiorhythm Steerable electrode catheter
US5423807A (en) 1992-04-16 1995-06-13 Implemed, Inc. Cryogenic mapping and ablation catheter
US5562720A (en) 1992-05-01 1996-10-08 Vesta Medical, Inc. Bipolar/monopolar endometrial ablation device and method
US5443463A (en) 1992-05-01 1995-08-22 Vesta Medical, Inc. Coagulating forceps
US5324284A (en) 1992-06-05 1994-06-28 Cardiac Pathways, Inc. Endocardial mapping and ablation system utilizing a separately controlled ablation catheter and method
WO1994002077A3 (en) 1992-07-15 1994-04-14 Angelase Inc Ablation catheter system
US5435308A (en) 1992-07-16 1995-07-25 Abbott Laboratories Multi-purpose multi-parameter cardiac catheter
US5687737A (en) 1992-10-09 1997-11-18 Washington University Computerized three-dimensional cardiac mapping with interactive visual displays
US5676693A (en) 1992-11-13 1997-10-14 Scimed Life Systems, Inc. Electrophysiology device
US5334193A (en) 1992-11-13 1994-08-02 American Cardiac Ablation Co., Inc. Fluid cooled ablation catheter
CA2109980A1 (en) 1992-12-01 1994-06-02 Mir A. Imran Steerable catheter with adjustable bend location and/or radius and method
US5348554A (en) 1992-12-01 1994-09-20 Cardiac Pathways Corporation Catheter for RF ablation with cooled electrode
US5469853A (en) 1992-12-11 1995-11-28 Tetrad Corporation Bendable ultrasonic probe and sheath for use therewith
US5324286A (en) 1993-01-21 1994-06-28 Arthur A. Fowle, Inc. Entrained cryogenic droplet transfer method and cryosurgical instrument
US5522870A (en) 1993-01-25 1996-06-04 State Of Israel, Ministry Of Defense, Rafael-Armaments Development Authority Fast changing heating-cooling device and method
US5452733A (en) 1993-02-22 1995-09-26 Stanford Surgical Technologies, Inc. Methods for performing thoracoscopic coronary artery bypass
US6237605B1 (en) 1996-10-22 2001-05-29 Epicor, Inc. Methods of epicardial ablation
US6311692B1 (en) 1996-10-22 2001-11-06 Epicor, Inc. Apparatus and method for diagnosis and therapy of electrophysiological disease
US5571215A (en) 1993-02-22 1996-11-05 Heartport, Inc. Devices and methods for intracardiac procedures
US5797960A (en) 1993-02-22 1998-08-25 Stevens; John H. Method and apparatus for thoracoscopic intracardiac procedures
US6161543A (en) 1993-02-22 2000-12-19 Epicor, Inc. Methods of epicardial ablation for creating a lesion around the pulmonary veins
WO1994023793A1 (en) 1993-04-15 1994-10-27 Siemens Aktiengesellschaft Therapeutic appliance for the treatment of conditions of the heart and of blood vessels in the vicinity of the heart
US5630837A (en) 1993-07-01 1997-05-20 Boston Scientific Corporation Acoustic ablation
DE69432148D1 (en) * 1993-07-01 2003-03-27 Boston Scient Ltd Catheter for image display, for displaying electrical signals and for ablation
US5571088A (en) 1993-07-01 1996-11-05 Boston Scientific Corporation Ablation catheters
DE4323585A1 (en) 1993-07-14 1995-01-19 Delma Elektro Med App Bipolar high-frequency surgical instrument
US5545200A (en) 1993-07-20 1996-08-13 Medtronic Cardiorhythm Steerable electrophysiology catheter
US5413550A (en) 1993-07-21 1995-05-09 Pti, Inc. Ultrasound therapy system with automatic dose control
US5558671A (en) 1993-07-22 1996-09-24 Yates; David C. Impedance feedback monitor for electrosurgical instrument
US5928191A (en) 1993-07-30 1999-07-27 E.P. Technologies, Inc. Variable curve electrophysiology catheter
US5921982A (en) 1993-07-30 1999-07-13 Lesh; Michael D. Systems and methods for ablating body tissue
US5431649A (en) 1993-08-27 1995-07-11 Medtronic, Inc. Method and apparatus for R-F ablation
US5437651A (en) 1993-09-01 1995-08-01 Research Medical, Inc. Medical suction apparatus
US5680860A (en) 1994-07-07 1997-10-28 Cardiac Pathways Corporation Mapping and/or ablation catheter with coilable distal extremity and method for using same
US5582609A (en) 1993-10-14 1996-12-10 Ep Technologies, Inc. Systems and methods for forming large lesions in body tissue using curvilinear electrode elements
WO1995010322A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Creating complex lesion patterns in body tissue
WO1995010225A1 (en) 1993-10-15 1995-04-20 Ep Technologies, Inc. Multiple electrode element for mapping and ablating
US5575810A (en) 1993-10-15 1996-11-19 Ep Technologies, Inc. Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like
US5575766A (en) 1993-11-03 1996-11-19 Daig Corporation Process for the nonsurgical mapping and treatment of atrial arrhythmia using catheters guided by shaped guiding introducers
US5427119A (en) 1993-11-03 1995-06-27 Daig Corporation Guiding introducer for right atrium
US5690611A (en) 1994-07-08 1997-11-25 Daig Corporation Process for the treatment of atrial arrhythima using a catheter guided by shaped giding introducers
US6090084A (en) * 1994-07-08 2000-07-18 Daig Corporation Shaped guiding introducers for use with a catheter for the treatment of atrial arrhythmia
US5536267A (en) 1993-11-08 1996-07-16 Zomed International Multiple electrode ablation apparatus
US5921924A (en) 1993-12-03 1999-07-13 Avitall; Boaz Mapping and ablation catheter system utilizing multiple control elements
US5462521A (en) 1993-12-21 1995-10-31 Angeion Corporation Fluid cooled and perfused tip for a catheter
WO1995017131A1 (en) 1993-12-22 1995-06-29 Monamed Medizintechnik Gmbh Ultrasonic marked cardiac ablation catheter
US5462545A (en) 1994-01-31 1995-10-31 New England Medical Center Hospitals, Inc. Catheter electrodes
DE69516444T2 (en) 1994-03-11 2001-01-04 Intravascular Res Ltd Ultrasonic transducer arrangement and method for its production
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5560362A (en) 1994-06-13 1996-10-01 Acuson Corporation Active thermal control of ultrasound transducers
US5681278A (en) 1994-06-23 1997-10-28 Cormedics Corp. Coronary vasculature treatment method
US5681308A (en) 1994-06-24 1997-10-28 Stuart D. Edwards Ablation apparatus for cardiac chambers
US5575788A (en) 1994-06-24 1996-11-19 Stuart D. Edwards Thin layer ablation apparatus
US5452582A (en) 1994-07-06 1995-09-26 Apd Cryogenics, Inc. Cryo-probe
US5545195A (en) 1994-08-01 1996-08-13 Boston Scientific Corporation Interstitial heating of tissue
US5810802A (en) 1994-08-08 1998-09-22 E.P. Technologies, Inc. Systems and methods for controlling tissue ablation using multiple temperature sensing elements
US6142994A (en) 1994-10-07 2000-11-07 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic a therapeutic element within the body
US6464700B1 (en) 1994-10-07 2002-10-15 Scimed Life Systems, Inc. Loop structures for positioning a diagnostic or therapeutic element on the epicardium or other organ surface
US5836947A (en) 1994-10-07 1998-11-17 Ep Technologies, Inc. Flexible structures having movable splines for supporting electrode elements
US6610055B1 (en) 1997-10-10 2003-08-26 Scimed Life Systems, Inc. Surgical method for positioning a diagnostic or therapeutic element on the epicardium or other organ surface
US5573532A (en) 1995-01-13 1996-11-12 Cryomedical Sciences, Inc. Cryogenic surgical instrument and method of manufacturing the same
US6063081A (en) 1995-02-22 2000-05-16 Medtronic, Inc. Fluid-assisted electrocautery device
US5676662A (en) 1995-03-17 1997-10-14 Daig Corporation Ablation catheter
WO1996034646A1 (en) 1995-05-01 1996-11-07 Medtronic Cardiorhythm Dual curve ablation catheter and method
WO1996034570A1 (en) 1995-05-01 1996-11-07 Ep Technologies, Inc. Systems and methods for obtaining desired lesion characteristics while ablating body tissue
US5688267A (en) 1995-05-01 1997-11-18 Ep Technologies, Inc. Systems and methods for sensing multiple temperature conditions during tissue ablation
WO1996034567A1 (en) 1995-05-02 1996-11-07 Heart Rhythm Technologies, Inc. System for controlling the energy delivered to a patient for ablation
US6293943B1 (en) 1995-06-07 2001-09-25 Ep Technologies, Inc. Tissue heating and ablation systems and methods which predict maximum tissue temperature
US5827216A (en) 1995-06-07 1998-10-27 Cormedics Corp. Method and apparatus for accessing the pericardial space
US6022346A (en) 1995-06-07 2000-02-08 Ep Technologies, Inc. Tissue heating and ablation systems and methods using self-heated electrodes
US6113592A (en) 1995-06-09 2000-09-05 Engineering & Research Associates, Inc. Apparatus and method for controlling ablation depth
US5697925A (en) 1995-06-09 1997-12-16 Engineering & Research Associates, Inc. Apparatus and method for thermal ablation
US5673695A (en) 1995-08-02 1997-10-07 Ep Technologies, Inc. Methods for locating and ablating accessory pathways in the heart
US5678550A (en) 1995-08-11 1997-10-21 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Apparatus and method for in situ detection of areas of cardiac electrical activity
US5836311A (en) 1995-09-20 1998-11-17 Medtronic, Inc. Method and apparatus for temporarily immobilizing a local area of tissue
US5707355A (en) 1995-11-15 1998-01-13 Zimmon Science Corporation Apparatus and method for the treatment of esophageal varices and mucosal neoplasms
US5906606A (en) 1995-12-04 1999-05-25 Target Therapuetics, Inc. Braided body balloon catheter
EP0879015A4 (en) * 1996-01-19 1999-11-17 Ep Technologies Multi-function electrode structures for electrically analyzing and heating body tissue
US5671747A (en) 1996-01-24 1997-09-30 Hewlett-Packard Company Ultrasound probe having interchangeable accessories
US5904711A (en) 1996-02-08 1999-05-18 Heartport, Inc. Expandable thoracoscopic defibrillation catheter system and method
US6032077A (en) 1996-03-06 2000-02-29 Cardiac Pathways Corporation Ablation catheter with electrical coupling via foam drenched with a conductive fluid
US5800482A (en) 1996-03-06 1998-09-01 Cardiac Pathways Corporation Apparatus and method for linear lesion ablation
US5755760A (en) 1996-03-11 1998-05-26 Medtronic, Inc. Deflectable catheter
US5676692A (en) 1996-03-28 1997-10-14 Indianapolis Center For Advanced Research, Inc. Focussed ultrasound tissue treatment method
US6302880B1 (en) 1996-04-08 2001-10-16 Cardima, Inc. Linear ablation assembly
US5800428A (en) 1996-05-16 1998-09-01 Angeion Corporation Linear catheter ablation system
US5993447A (en) 1996-08-16 1999-11-30 United States Surgical Apparatus for thermal treatment of tissue
US5846187A (en) 1996-09-13 1998-12-08 Genzyme Corporation Redo sternotomy retractor
US5697928A (en) 1996-09-23 1997-12-16 Uab Research Foundation Cardic electrode catheter
US5785706A (en) 1996-11-18 1998-07-28 Daig Corporation Nonsurgical mapping and treatment of cardiac arrhythmia using a catheter contained within a guiding introducer containing openings
US5941893A (en) 1996-12-02 1999-08-24 Angiotrax, Inc. Apparatus for transluminally performing surgery
US5931810A (en) 1996-12-05 1999-08-03 Comedicus Incorporated Method for accessing the pericardial space
US5782828A (en) 1996-12-11 1998-07-21 Irvine Biomedical, Inc. Ablation catheter with multiple flexible curves
US6071279A (en) 1996-12-19 2000-06-06 Ep Technologies, Inc. Branched structures for supporting multiple electrode elements
US5916213A (en) 1997-02-04 1999-06-29 Medtronic, Inc. Systems and methods for tissue mapping and ablation
US5844349A (en) 1997-02-11 1998-12-01 Tetrad Corporation Composite autoclavable ultrasonic transducers and methods of making
US5788636A (en) 1997-02-25 1998-08-04 Acuson Corporation Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue
US5899898A (en) 1997-02-27 1999-05-04 Cryocath Technologies Inc. Cryosurgical linear ablation
US5954661A (en) 1997-03-31 1999-09-21 Thomas Jefferson University Tissue characterization and treatment using pacing
US5906580A (en) 1997-05-05 1999-05-25 Creare Inc. Ultrasound system and method of administering ultrasound including a plurality of multi-layer transducer elements
US5971983A (en) 1997-05-09 1999-10-26 The Regents Of The University Of California Tissue ablation device and method of use
US5792140A (en) 1997-05-15 1998-08-11 Irvine Biomedical, Inc. Catheter having cooled multiple-needle electrode
US5849028A (en) 1997-05-16 1998-12-15 Irvine Biomedical, Inc. Catheter and method for radiofrequency ablation of cardiac tissue
US6217576B1 (en) 1997-05-19 2001-04-17 Irvine Biomedical Inc. Catheter probe for treating focal atrial fibrillation in pulmonary veins
US6245064B1 (en) 1997-07-08 2001-06-12 Atrionix, Inc. Circumferential ablation device assembly
US6117101A (en) 1997-07-08 2000-09-12 The Regents Of The University Of California Circumferential ablation device assembly
US5908029A (en) 1997-08-15 1999-06-01 Heartstent Corporation Coronary artery bypass with reverse flow
US6152920A (en) 1997-10-10 2000-11-28 Ep Technologies, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body
US6007499A (en) 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
US6120500A (en) 1997-11-12 2000-09-19 Daig Corporation Rail catheter ablation and mapping system
US6270471B1 (en) 1997-12-23 2001-08-07 Misonix Incorporated Ultrasonic probe with isolated outer cannula
US6251092B1 (en) 1997-12-30 2001-06-26 Medtronic, Inc. Deflectable guiding catheter
US6575956B1 (en) 1997-12-31 2003-06-10 Pharmasonics, Inc. Methods and apparatus for uniform transcutaneous therapeutic ultrasound
US6142993A (en) 1998-02-27 2000-11-07 Ep Technologies, Inc. Collapsible spline structure using a balloon as an expanding actuator
US6120496A (en) 1998-05-05 2000-09-19 Scimed Life Systems, Inc. Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and coupling device for use with same
US6231518B1 (en) 1998-05-26 2001-05-15 Comedicus Incorporated Intrapericardial electrophysiological procedures
US6186951B1 (en) 1998-05-26 2001-02-13 Riverside Research Institute Ultrasonic systems and methods for fluid perfusion and flow rate measurement
US6238393B1 (en) 1998-07-07 2001-05-29 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US6251128B1 (en) 1998-09-01 2001-06-26 Fidus Medical Technology Corporation Microwave ablation catheter with loop configuration
US6245065B1 (en) 1998-09-10 2001-06-12 Scimed Life Systems, Inc. Systems and methods for controlling power in an electrosurgical probe
US6425867B1 (en) 1998-09-18 2002-07-30 University Of Washington Noise-free real time ultrasonic imaging of a treatment site undergoing high intensity focused ultrasound therapy
US6245062B1 (en) 1998-10-23 2001-06-12 Afx, Inc. Directional reflector shield assembly for a microwave ablation instrument
US6296619B1 (en) 1998-12-30 2001-10-02 Pharmasonics, Inc. Therapeutic ultrasonic catheter for delivering a uniform energy dose
JP2002536040A (en) 1999-02-02 2002-10-29 トランサージカル,インコーポレイテッド Body high intensity focused ultrasound applicator
US6217528B1 (en) 1999-02-11 2001-04-17 Scimed Life Systems, Inc. Loop structure having improved tissue contact capability
US20010007070A1 (en) 1999-04-05 2001-07-05 Medtronic, Inc. Ablation catheter assembly and method for isolating a pulmonary vein
US6325797B1 (en) 1999-04-05 2001-12-04 Medtronic, Inc. Ablation catheter and method for isolating a pulmonary vein
US6398792B1 (en) 1999-06-21 2002-06-04 O'connor Lawrence Angioplasty catheter with transducer using balloon for focusing of ultrasonic energy and method for use
US6235024B1 (en) 1999-06-21 2001-05-22 Hosheng Tu Catheters system having dual ablation capability
US6461356B1 (en) 1999-07-01 2002-10-08 C.R. Bard, Inc. Medical device having an incrementally displaceable electrode
US6371955B1 (en) 1999-08-10 2002-04-16 Biosense Webster, Inc. Atrial branding iron catheter and a method for treating atrial fibrillation
US6332881B1 (en) 1999-09-01 2001-12-25 Cardima, Inc. Surgical ablation tool
US6385472B1 (en) 1999-09-10 2002-05-07 Stereotaxis, Inc. Magnetically navigable telescoping catheter and method of navigating telescoping catheter
US6368275B1 (en) 1999-10-07 2002-04-09 Acuson Corporation Method and apparatus for diagnostic medical information gathering, hyperthermia treatment, or directed gene therapy
EP1095627A1 (en) 1999-10-27 2001-05-02 Everest Medical Corporation Electrosurgical probe for surface treatment
US6645199B1 (en) 1999-11-22 2003-11-11 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements contact with body tissue and expandable push devices for use with same
US6626855B1 (en) 1999-11-26 2003-09-30 Therus Corpoation Controlled high efficiency lesion formation using high intensity ultrasound
US7706882B2 (en) * 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US6413254B1 (en) 2000-01-19 2002-07-02 Medtronic Xomed, Inc. Method of tongue reduction by thermal ablation using high intensity focused ultrasound
US6595934B1 (en) 2000-01-19 2003-07-22 Medtronic Xomed, Inc. Methods of skin rejuvenation using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
EP1265674B1 (en) 2000-03-24 2008-09-17 ProRhythm, Inc. Apparatus for intrabody thermal treatment
US6419648B1 (en) 2000-04-21 2002-07-16 Insightec-Txsonics Ltd. Systems and methods for reducing secondary hot spots in a phased array focused ultrasound system
US6488680B1 (en) 2000-04-27 2002-12-03 Medtronic, Inc. Variable length electrodes for delivery of irrigated ablation
DE60111517T2 (en) 2000-04-27 2006-05-11 Medtronic, Inc., Minneapolis Vibration-sensitive ablation
US6477396B1 (en) 2000-07-07 2002-11-05 Biosense Webster, Inc. Mapping and ablation catheter
US7628780B2 (en) 2001-01-13 2009-12-08 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US6827714B2 (en) * 2001-03-07 2004-12-07 Scimed Life Systems, Inc. Internal indifferent electrode device for use with lesion creation apparatus and method of forming lesions using the same
US7250048B2 (en) 2001-04-26 2007-07-31 Medtronic, Inc. Ablation system and method of use
US6585733B2 (en) * 2001-09-28 2003-07-01 Ethicon, Inc. Surgical treatment for atrial fibrillation using radiofrequency technology
US6656175B2 (en) 2001-12-11 2003-12-02 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US6827715B2 (en) 2002-01-25 2004-12-07 Medtronic, Inc. System and method of performing an electrosurgical procedure
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US20030181890A1 (en) * 2002-03-22 2003-09-25 Schulze Dale R. Medical device that removably attaches to a bodily organ
US7118566B2 (en) 2002-05-16 2006-10-10 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US7083620B2 (en) 2002-10-30 2006-08-01 Medtronic, Inc. Electrosurgical hemostat
US20040138621A1 (en) 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US6837848B2 (en) 2003-01-15 2005-01-04 Medtronic, Inc. Methods and apparatus for accessing and stabilizing an area of the heart
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US7438714B2 (en) 2003-09-12 2008-10-21 Boston Scientific Scimed, Inc. Vacuum-based catheter stabilizer
US7569052B2 (en) * 2003-09-12 2009-08-04 Boston Scientific Scimed, Inc. Ablation catheter with tissue protecting assembly
WO2005112812A1 (en) 2004-05-14 2005-12-01 Medtronic, Inc. Method and devices for treating atrial fibrillation by mass ablation

Patent Citations (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3807403A (en) * 1972-06-14 1974-04-30 Frigitronics Of Conn Inc Cryosurgical apparatus
US3859986A (en) * 1973-06-20 1975-01-14 Jiro Okada Surgical device
US3862627A (en) * 1973-08-16 1975-01-28 Sr Wendel J Hans Suction electrode
US4082096A (en) * 1973-12-10 1978-04-04 Benson Jerrel W Cryosurgical system
US4018227A (en) * 1975-10-09 1977-04-19 Cryomedics, Inc. Cryosurgical instrument
US4072152A (en) * 1976-02-23 1978-02-07 Linehan John H Orthopedic cryosurgical apparatus
US4248224A (en) * 1978-08-01 1981-02-03 Jones James W Double venous cannula
US4377168A (en) * 1981-02-27 1983-03-22 Wallach Surgical Instruments, Inc. Cryosurgical instrument
US5080102A (en) * 1983-12-14 1992-01-14 Edap International, S.A. Examining, localizing and treatment with ultrasound
US4562900A (en) * 1984-12-20 1986-01-07 Varian Associates, Inc. Lens system for acoustic transducer array
US4736749A (en) * 1985-04-26 1988-04-12 Astra-Tech Aktiebolag Holder for medical use fixed by vacuum
US4917095A (en) * 1985-11-18 1990-04-17 Indianapolis Center For Advanced Research, Inc. Ultrasound location and therapy method and apparatus for calculi in the body
US4802475A (en) * 1987-06-22 1989-02-07 Weshahy Ahmed H A G Methods and apparatus of applying intra-lesional cryotherapy
US4815470A (en) * 1987-11-13 1989-03-28 Advanced Diagnostic Medical Systems, Inc. Inflatable sheath for ultrasound probe
US5108390A (en) * 1988-11-14 1992-04-28 Frigitronics, Inc. Flexible cryoprobe
US5078713A (en) * 1988-12-01 1992-01-07 Spembly Medical Limited Cryosurgical probe
US4916922A (en) * 1989-05-09 1990-04-17 Mullens Patrick L Rapid freezing apparatus
US5100388A (en) * 1989-09-15 1992-03-31 Interventional Thermodynamics, Inc. Method and device for thermal ablation of hollow body organs
US5080660A (en) * 1990-05-11 1992-01-14 Applied Urology, Inc. Electrosurgical electrode
US5178133A (en) * 1991-03-26 1993-01-12 Pena Louis T Laparoscopic retractor and sheath
US5500013A (en) * 1991-10-04 1996-03-19 Scimed Life Systems, Inc. Biodegradable drug delivery vascular stent
US5400770A (en) * 1992-01-15 1995-03-28 Nakao; Naomi L. Device utilizable with endoscope and related method
US5486193A (en) * 1992-01-22 1996-01-23 C. R. Bard, Inc. System for the percutaneous transluminal front-end loading delivery of a prosthetic occluder
US5730704A (en) * 1992-02-24 1998-03-24 Avitall; Boaz Loop electrode array mapping and ablation catheter for cardiac chambers
US5397304A (en) * 1992-04-10 1995-03-14 Medtronic Cardiorhythm Shapable handle for steerable electrode catheter
US5871525A (en) * 1992-04-13 1999-02-16 Ep Technologies, Inc. Steerable ablation catheter system
US5281215A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Cryogenic catheter
US5281213A (en) * 1992-04-16 1994-01-25 Implemed, Inc. Catheter for ice mapping and ablation
US5713942A (en) * 1992-05-01 1998-02-03 Vesta Medical, Inc. Body cavity ablation apparatus and model
US5277201A (en) * 1992-05-01 1994-01-11 Vesta Medical, Inc. Endometrial ablation apparatus and method
US5295484A (en) * 1992-05-19 1994-03-22 Arizona Board Of Regents For And On Behalf Of The University Of Arizona Apparatus and method for intra-cardiac ablation of arrhythmias
US5275595A (en) * 1992-07-06 1994-01-04 Dobak Iii John D Cryosurgical instrument
US5403309A (en) * 1992-07-31 1995-04-04 Spembly Medical Limited Cryosurgical ablation
US5498248A (en) * 1992-11-12 1996-03-12 Implemed, Inc. Iontophoretic structure for medical devices
US5409483A (en) * 1993-01-22 1995-04-25 Jeffrey H. Reese Direct visualization surgical probe
US5881732A (en) * 1993-01-29 1999-03-16 Cardima, Inc. Intravascular method and system for treating arrhythmia
US5735290A (en) * 1993-02-22 1998-04-07 Heartport, Inc. Methods and systems for performing thoracoscopic coronary bypass and other procedures
US5403311A (en) * 1993-03-29 1995-04-04 Boston Scientific Corporation Electro-coagulation and ablation and other electrotherapeutic treatments of body tissue
US5402792A (en) * 1993-03-30 1995-04-04 Shimadzu Corporation Ultrasonic medical apparatus
US5487757A (en) * 1993-07-20 1996-01-30 Medtronic Cardiorhythm Multicurve deflectable catheter
US5385148A (en) * 1993-07-30 1995-01-31 The Regents Of The University Of California Cardiac imaging and ablation catheter
US5718701A (en) * 1993-08-11 1998-02-17 Electro-Catheter Corporation Ablation electrode
US5405376A (en) * 1993-08-27 1995-04-11 Medtronic, Inc. Method and apparatus for ablation
US5396887A (en) * 1993-09-23 1995-03-14 Cardiac Pathways Corporation Apparatus and method for detecting contact pressure
US5607462A (en) * 1993-09-24 1997-03-04 Cardiac Pathways Corporation Catheter assembly, catheter and multi-catheter introducer for use therewith
US5496312A (en) * 1993-10-07 1996-03-05 Valleylab Inc. Impedance and temperature generator control
US5400783A (en) * 1993-10-12 1995-03-28 Cardiac Pathways Corporation Endocardial mapping apparatus with rotatable arm and method
US5871523A (en) * 1993-10-15 1999-02-16 Ep Technologies, Inc. Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5879296A (en) * 1993-11-03 1999-03-09 Daig Corporation Guiding introducers for use in the treatment of left ventricular tachycardia
US5497774A (en) * 1993-11-03 1996-03-12 Daig Corporation Guiding introducer for left atrium
US5730127A (en) * 1993-12-03 1998-03-24 Avitall; Boaz Mapping and ablation catheter system
US5487385A (en) * 1993-12-03 1996-01-30 Avitall; Boaz Atrial mapping and ablation catheter system
US5617854A (en) * 1994-06-22 1997-04-08 Munsif; Anand Shaped catheter device and method
US5505730A (en) * 1994-06-24 1996-04-09 Stuart D. Edwards Thin layer ablation apparatus
US5885278A (en) * 1994-10-07 1999-03-23 E.P. Technologies, Inc. Structures for deploying movable electrode elements
US5722402A (en) * 1994-10-11 1998-03-03 Ep Technologies, Inc. Systems and methods for guiding movable electrode elements within multiple-electrode structures
US5595183A (en) * 1995-02-17 1997-01-21 Ep Technologies, Inc. Systems and methods for examining heart tissue employing multiple electrode structures and roving electrodes
US6358248B1 (en) * 1995-02-22 2002-03-19 Medtronic, Inc. Ball point fluid-assisted electrocautery device
US5735280A (en) * 1995-05-02 1998-04-07 Heart Rhythm Technologies, Inc. Ultrasound energy delivery system and method
US5718241A (en) * 1995-06-07 1998-02-17 Biosense, Inc. Apparatus and method for treating cardiac arrhythmias with no discrete target
US5897553A (en) * 1995-11-02 1999-04-27 Medtronic, Inc. Ball point fluid-assisted electrocautery device
US5590657A (en) * 1995-11-06 1997-01-07 The Regents Of The University Of Michigan Phased array ultrasound system and method for cardiac ablation
US5716389A (en) * 1995-11-13 1998-02-10 Walinsky; Paul Cardiac ablation catheter arrangement with movable guidewire
US5733280A (en) * 1995-11-15 1998-03-31 Avitall; Boaz Cryogenic epicardial mapping and ablation
US5895417A (en) * 1996-03-06 1999-04-20 Cardiac Pathways Corporation Deflectable loop design for a linear lesion ablation apparatus
US6502575B1 (en) * 1996-05-03 2003-01-07 Clemens J. Jacobs Instrument for interrupting conduction paths within the heart
US20030045872A1 (en) * 1996-05-03 2003-03-06 Jacobs Clemens J. Instrument for interrupting conduction paths within the heart
US5730074A (en) * 1996-06-07 1998-03-24 Farmer Fabrications, Inc. Liquid dispenser for seed planter
US5882346A (en) * 1996-07-15 1999-03-16 Cardiac Pathways Corporation Shapable catheter using exchangeable core and method of use
US5720775A (en) * 1996-07-31 1998-02-24 Cordis Corporation Percutaneous atrial line ablation catheter
US5893848A (en) * 1996-10-24 1999-04-13 Plc Medical Systems, Inc. Gauging system for monitoring channel depth in percutaneous endocardial revascularization
US5897554A (en) * 1997-03-01 1999-04-27 Irvine Biomedical, Inc. Steerable catheter having a loop electrode
US5873845A (en) * 1997-03-17 1999-02-23 General Electric Company Ultrasound transducer with focused ultrasound refraction plate
US5879295A (en) * 1997-04-02 1999-03-09 Medtronic, Inc. Enhanced contact steerable bowing electrode catheter assembly
US5876399A (en) * 1997-05-28 1999-03-02 Irvine Biomedical, Inc. Catheter system and methods thereof
US6012457A (en) * 1997-07-08 2000-01-11 The Regents Of The University Of California Device and method for forming a circumferential conduction block in a pulmonary vein
US6858028B2 (en) * 1997-07-29 2005-02-22 Medtronic, Inc. Tissue sealing electrosurgery device and methods of sealing tissue
US6527767B2 (en) * 1998-05-20 2003-03-04 New England Medical Center Cardiac ablation system and method for treatment of cardiac arrhythmias and transmyocardial revascularization
US6706039B2 (en) * 1998-07-07 2004-03-16 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US6849073B2 (en) * 1998-07-07 2005-02-01 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6537272B2 (en) * 1998-07-07 2003-03-25 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US6537248B2 (en) * 1998-07-07 2003-03-25 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US6016811A (en) * 1998-09-01 2000-01-25 Fidus Medical Technology Corporation Method of using a microwave ablation catheter with a loop configuration
US6042556A (en) * 1998-09-04 2000-03-28 University Of Washington Method for determining phase advancement of transducer elements in high intensity focused ultrasound
US6702811B2 (en) * 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US20050010095A1 (en) * 1999-04-05 2005-01-13 Medtronic, Inc. Multi-purpose catheter apparatus and method of use
US6692450B1 (en) * 2000-01-19 2004-02-17 Medtronic Xomed, Inc. Focused ultrasound ablation devices having selectively actuatable ultrasound emitting elements and methods of using the same
US20040015106A1 (en) * 2000-01-19 2004-01-22 Coleman R. Glen Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US6361531B1 (en) * 2000-01-21 2002-03-26 Medtronic Xomed, Inc. Focused ultrasound ablation devices having malleable handle shafts and methods of using the same
US20020002372A1 (en) * 2000-04-27 2002-01-03 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6706038B2 (en) * 2000-04-27 2004-03-16 Medtronic, Inc. System and method for assessing transmurality of ablation lesions
US6514250B1 (en) * 2000-04-27 2003-02-04 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6699240B2 (en) * 2001-04-26 2004-03-02 Medtronic, Inc. Method and apparatus for tissue ablation
US20040049179A1 (en) * 2001-04-26 2004-03-11 Francischelli David E. Ablation system
US20040044340A1 (en) * 2001-04-26 2004-03-04 Francischelli David E. Ablation system and method of use
US20050033280A1 (en) * 2001-04-26 2005-02-10 Francischelli David E. Method and system for treatment of atrial tachyarrhythmias
US20040015219A1 (en) * 2002-05-16 2004-01-22 Francischelli David E. Device and method for ablation of cardiac tissue
US20060009759A1 (en) * 2004-06-02 2006-01-12 Chrisitian Steven C Loop ablation apparatus and method

Cited By (215)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040215183A1 (en) * 1995-02-22 2004-10-28 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US9770282B2 (en) 1995-02-22 2017-09-26 Medtronic, Inc. Apparatus and method for creating, maintaining, and controlling a virtual electrode used for the ablation of tissue
US7794460B2 (en) 1995-02-22 2010-09-14 Medtronic, Inc. Method of ablating tissue
US20070208332A1 (en) * 1995-02-22 2007-09-06 Mulier Peter M Pen-type electrosurgical instrument
US20030191462A1 (en) * 1996-05-03 2003-10-09 Jacobs Clemens J. Method for interrupting conduction paths within the heart
US20060079888A1 (en) * 1997-07-18 2006-04-13 Mulier Peter M J Device and method for ablating tissue
US20040236322A1 (en) * 1997-07-18 2004-11-25 Mulier Peter M.J. Device and method for ablating tissue
US7678111B2 (en) 1997-07-18 2010-03-16 Medtronic, Inc. Device and method for ablating tissue
US20060009760A1 (en) * 1998-07-07 2006-01-12 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US9113896B2 (en) 1998-07-07 2015-08-25 Medtronic, Inc. Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US7699805B2 (en) 1998-07-07 2010-04-20 Medtronic, Inc. Helical coil apparatus for ablation of tissue
US20070093808A1 (en) * 1998-07-07 2007-04-26 Mulier Peter M J Method and apparatus for creating a bi-polar virtual electrode used for the ablation of tissue
US20060052770A1 (en) * 1998-07-07 2006-03-09 Medtronic, Inc. Helical needle apparatus for creating a virtual electrode used for the ablation of tissue
US20050267454A1 (en) * 2000-01-19 2005-12-01 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20060229594A1 (en) * 2000-01-19 2006-10-12 Medtronic, Inc. Method for guiding a medical device
US8221402B2 (en) 2000-01-19 2012-07-17 Medtronic, Inc. Method for guiding a medical device
US20040015106A1 (en) * 2000-01-19 2004-01-22 Coleman R. Glen Focused ultrasound ablation devices having selectively actuatable emitting elements and methods of using the same
US7706882B2 (en) 2000-01-19 2010-04-27 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area
US20070049920A1 (en) * 2000-03-06 2007-03-01 Tissuelink Medical, Inc. Fluid-Assisted Medical Devices, Fluid Delivery Systems and Controllers for Such Devices, and Methods
US8568409B2 (en) 2000-03-06 2013-10-29 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US9381061B2 (en) 2000-03-06 2016-07-05 Medtronic Advanced Energy Llc Fluid-assisted medical devices, systems and methods
US20110066146A1 (en) * 2000-04-27 2011-03-17 Jahns Scott E Suction Stabilized Epicardial Ablation Devices
US8162933B2 (en) 2000-04-27 2012-04-24 Medtronic, Inc. Vibration sensitive ablation device and method
US7818039B2 (en) 2000-04-27 2010-10-19 Medtronic, Inc. Suction stabilized epicardial ablation devices
US20070118107A1 (en) * 2000-04-27 2007-05-24 Francischelli David E Vibration sensitive ablation device and method
US20040138656A1 (en) * 2000-04-27 2004-07-15 Francischelli David E. System and method for assessing transmurality of ablation lesions
US9693819B2 (en) 2000-04-27 2017-07-04 Medtronic, Inc. Vibration sensitive ablation device and method
US7706894B2 (en) 2000-10-10 2010-04-27 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US20100168740A1 (en) * 2000-10-10 2010-07-01 Medtronic, Inc. Heart Wall Ablation/Mapping Catheter and Method
US20050273006A1 (en) * 2000-10-10 2005-12-08 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US8706260B2 (en) 2000-10-10 2014-04-22 Medtronic, Inc. Heart wall ablation/mapping catheter and method
US7740623B2 (en) 2001-01-13 2010-06-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20050209564A1 (en) * 2001-01-13 2005-09-22 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20060041243A1 (en) * 2001-01-13 2006-02-23 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US8262649B2 (en) 2001-04-26 2012-09-11 Medtronic, Inc. Method and apparatus for tissue ablation
US7959626B2 (en) 2001-04-26 2011-06-14 Medtronic, Inc. Transmural ablation systems and methods
US20060195082A1 (en) * 2001-04-26 2006-08-31 Francischelli David E Method and apparatus for tissue ablation
US20050033280A1 (en) * 2001-04-26 2005-02-10 Francischelli David E. Method and system for treatment of atrial tachyarrhythmias
US20070270799A1 (en) * 2001-04-26 2007-11-22 Francischelli David E Method and apparatus for tissue ablation
US20040049179A1 (en) * 2001-04-26 2004-03-11 Francischelli David E. Ablation system
US7824399B2 (en) 2001-04-26 2010-11-02 Medtronic, Inc. Ablation system and method of use
US8512337B2 (en) 2001-04-26 2013-08-20 Medtronic, Inc. Method and system for treatment of atrial tachyarrhythmias
US20080071271A1 (en) * 2001-04-26 2008-03-20 Francischelli David E Method and apparatus for tissue ablation
US8221415B2 (en) 2001-04-26 2012-07-17 Medtronic, Inc. Method and apparatus for tissue ablation
US8096959B2 (en) 2001-05-21 2012-01-17 Medtronic, Inc. Trans-septal catheter with retention mechanism
US20040078069A1 (en) * 2001-12-11 2004-04-22 Francischelli David E. Method and system for treatment of atrial tachyarrhythmias
US20080275439A1 (en) * 2002-01-25 2008-11-06 David Francischelli Cardiac ablation and electrical interface system and instrument
US7967816B2 (en) 2002-01-25 2011-06-28 Medtronic, Inc. Fluid-assisted electrosurgical instrument with shapeable electrode
US20050165392A1 (en) * 2002-01-25 2005-07-28 Medtronic, Inc. System and method of performing an electrosurgical procedure
US20070049923A1 (en) * 2002-05-16 2007-03-01 Jahns Scott E Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US20040015219A1 (en) * 2002-05-16 2004-01-22 Francischelli David E. Device and method for ablation of cardiac tissue
US8414573B2 (en) 2002-05-16 2013-04-09 Medtronic, Inc. Device and method for ablation of cardiac tissue
US7975703B2 (en) 2002-05-16 2011-07-12 Medtronic, Inc. Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue
US20060041254A1 (en) * 2002-10-30 2006-02-23 Medtronic, Inc. Electrosurgical hemostat
US7963963B2 (en) 2002-10-30 2011-06-21 Medtronic, Inc. Electrosurgical hemostat
US20060195083A1 (en) * 2002-10-30 2006-08-31 Jahns Scott E Electrosurgical hemostat
US7744562B2 (en) 2003-01-14 2010-06-29 Medtronics, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US8273072B2 (en) 2003-01-14 2012-09-25 Medtronic, Inc. Devices and methods for interstitial injection of biologic agents into tissue
US20040138621A1 (en) * 2003-01-14 2004-07-15 Jahns Scott E. Devices and methods for interstitial injection of biologic agents into tissue
US20040220560A1 (en) * 2003-04-29 2004-11-04 Briscoe Roderick E. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US20090138008A1 (en) * 2003-04-29 2009-05-28 Medtronic, Inc. Endocardial Dispersive Electrode for Use with a Monopolar RF Ablation Pen
US7871409B2 (en) 2003-04-29 2011-01-18 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US8333764B2 (en) 2004-05-12 2012-12-18 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
US20050256522A1 (en) * 2004-05-12 2005-11-17 Medtronic, Inc. Device and method for determining tissue thickness and creating cardiac ablation lesions
US8801707B2 (en) 2004-05-14 2014-08-12 Medtronic, Inc. Method and devices for treating atrial fibrillation by mass ablation
US20100145331A1 (en) * 2004-06-02 2010-06-10 Chrisitian Steven C Loop Ablation Apparatus and Method
US20060047278A1 (en) * 2004-06-02 2006-03-02 Christian Steven C Ablation device with jaws
US7758576B2 (en) 2004-06-02 2010-07-20 Medtronic, Inc. Clamping ablation tool and method
US7758580B2 (en) 2004-06-02 2010-07-20 Medtronic, Inc. Compound bipolar ablation device and method
US8172837B2 (en) 2004-06-02 2012-05-08 Medtronic, Inc. Clamping ablation tool and method
US20060009759A1 (en) * 2004-06-02 2006-01-12 Chrisitian Steven C Loop ablation apparatus and method
US7678108B2 (en) 2004-06-02 2010-03-16 Medtronic, Inc. Loop ablation apparatus and method
US20060020263A1 (en) * 2004-06-02 2006-01-26 Rothstein Paul T Clamping ablation tool and method
US20110087205A1 (en) * 2004-06-02 2011-04-14 Christian Steven C Ablation device with jaws
US20110071519A1 (en) * 2004-06-02 2011-03-24 Rothstein Paul T Clamping Ablation Tool and Method
US20060036236A1 (en) * 2004-06-02 2006-02-16 Rothstein Paul T Compound bipolar ablation device and method
US7875028B2 (en) 2004-06-02 2011-01-25 Medtronic, Inc. Ablation device with jaws
US8162941B2 (en) 2004-06-02 2012-04-24 Medtronic, Inc. Ablation device with jaws
US9656063B2 (en) 2004-06-18 2017-05-23 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US8663245B2 (en) 2004-06-18 2014-03-04 Medtronic, Inc. Device for occlusion of a left atrial appendage
US8409219B2 (en) 2004-06-18 2013-04-02 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US20100042110A1 (en) * 2004-06-18 2010-02-18 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US20060020271A1 (en) * 2004-06-18 2006-01-26 Stewart Mark T Methods and devices for occlusion of an atrial appendage
US20100145361A1 (en) * 2004-06-18 2010-06-10 Francischelli David E Methods and Devices for Occlusion of an Atrial Appendage
US8926635B2 (en) 2004-06-18 2015-01-06 Medtronic, Inc. Methods and devices for occlusion of an atrial appendage
US20100256631A1 (en) * 2005-12-29 2010-10-07 Boston Scientific Scimed, Inc. Foam electrode and method of use thereof during tissue resection
US7744591B2 (en) * 2005-12-29 2010-06-29 Boston Scientific Scimed, Inc. Foam electrode and method of use thereof during tissue resection
US8016826B2 (en) 2005-12-29 2011-09-13 Boston Scientific Scimed, Inc. Foam electrode and method of use thereof during tissue resection
US20070156127A1 (en) * 2005-12-29 2007-07-05 Boston Scientific Scimed, Inc. Foam electrode and method of use thereof during tissue resection
US20070208336A1 (en) * 2006-01-27 2007-09-06 David Kim Ablation device and system for guiding ablation device into body
US20070203484A1 (en) * 2006-01-27 2007-08-30 David Kim Methods of using ablation device and of guiding ablation device into body
US9572557B2 (en) 2006-02-21 2017-02-21 Kardium Inc. Method and device for closing holes in tissue
US8150499B2 (en) 2006-05-19 2012-04-03 Kardium Inc. Automatic atherectomy system
US20110125172A1 (en) * 2006-05-19 2011-05-26 Kardium Inc. Automatic atherectomy system
US20070270688A1 (en) * 2006-05-19 2007-11-22 Daniel Gelbart Automatic atherectomy system
US8532746B2 (en) 2006-05-19 2013-09-10 Kardium Inc. Automatic atherectomy system
US20080039746A1 (en) * 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US9724119B2 (en) 2006-05-25 2017-08-08 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US9227088B2 (en) 2006-05-25 2016-01-05 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US20100217162A1 (en) * 2006-05-25 2010-08-26 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US9119634B2 (en) 2006-06-28 2015-09-01 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US9119633B2 (en) 2006-06-28 2015-09-01 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US8920411B2 (en) 2006-06-28 2014-12-30 Kardium Inc. Apparatus and method for intra-cardiac mapping and ablation
US9814511B2 (en) * 2006-06-28 2017-11-14 Medtronic Cryocath Lp Variable geometry cooling chamber
US20080009851A1 (en) * 2006-06-28 2008-01-10 Dan Wittenberger Variable geometry cooling chamber
US9192468B2 (en) 2006-06-28 2015-11-24 Kardium Inc. Method for anchoring a mitral valve
US20080004534A1 (en) * 2006-06-28 2008-01-03 Daniel Gelbart Intra-cardiac mapping and ablation method
WO2008082494A3 (en) * 2006-12-20 2008-08-21 Sen Ji Esophagial visualization device
US20100094129A1 (en) * 2006-12-20 2010-04-15 Frank Marchilinski Esophagial visualization device
WO2008082494A2 (en) * 2006-12-20 2008-07-10 The Trustees Of The University Of Pennsylvania Esophagial visualization device
US9861829B2 (en) * 2007-04-23 2018-01-09 Plasmology4, Inc. Cold plasma electroporation of medication and associated methods
US20170087372A1 (en) * 2007-04-23 2017-03-30 Plasmology4, Inc. Cold Plasma Electroporation of Medication and Associated Methods
US9820810B2 (en) 2007-11-16 2017-11-21 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US9603661B2 (en) 2007-11-16 2017-03-28 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US9750569B2 (en) 2007-11-16 2017-09-05 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US8932287B2 (en) 2007-11-16 2015-01-13 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US9877779B2 (en) 2007-11-16 2018-01-30 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US9585717B2 (en) 2007-11-16 2017-03-07 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US9839474B2 (en) 2007-11-16 2017-12-12 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US20090131930A1 (en) * 2007-11-16 2009-05-21 Daniel Gelbart Medical device for use in bodily lumens, for example an atrium
US8906011B2 (en) 2007-11-16 2014-12-09 Kardium Inc. Medical device for use in bodily lumens, for example an atrium
US20090222001A1 (en) * 2007-12-28 2009-09-03 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Devices, Methods and Systems
US20090171346A1 (en) * 2007-12-28 2009-07-02 Greg Leyh High conductivity inductively equalized electrodes and methods
US8882756B2 (en) 2007-12-28 2014-11-11 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical devices, methods and systems
US20090192441A1 (en) * 2008-01-25 2009-07-30 Daniel Gelbart Liposuction system
US8489172B2 (en) 2008-01-25 2013-07-16 Kardium Inc. Liposuction system
US20110022166A1 (en) * 2008-05-13 2011-01-27 Kardium Inc. Medical device for constricting tissue or a bodily orifice, for example a mitral valve
US9744038B2 (en) 2008-05-13 2017-08-29 Kardium Inc. Medical device for constricting tissue or a bodily orifice, for example a mitral valve
US8454591B2 (en) 2008-06-05 2013-06-04 Cutera, Inc. Subcutaneous electric field distribution system and methods
US8172835B2 (en) 2008-06-05 2012-05-08 Cutera, Inc. Subcutaneous electric field distribution system and methods
US20090306647A1 (en) * 2008-06-05 2009-12-10 Greg Leyh Dynamically controllable multi-electrode apparatus & methods
US20100022999A1 (en) * 2008-07-24 2010-01-28 Gollnick David A Symmetrical rf electrosurgical system and methods
US8197477B2 (en) 2008-10-21 2012-06-12 Hermes Innovations Llc Tissue ablation methods
US8540708B2 (en) 2008-10-21 2013-09-24 Hermes Innovations Llc Endometrial ablation method
US8382753B2 (en) 2008-10-21 2013-02-26 Hermes Innovations, LLC Tissue ablation methods
US9662163B2 (en) 2008-10-21 2017-05-30 Hermes Innovations Llc Endometrial ablation devices and systems
US8500732B2 (en) 2008-10-21 2013-08-06 Hermes Innovations Llc Endometrial ablation devices and systems
US8690873B2 (en) 2008-10-21 2014-04-08 Hermes Innovations Llc Endometrial ablation devices and systems
US20100114089A1 (en) * 2008-10-21 2010-05-06 Hermes Innovations Llc Endometrial ablation devices and systems
US8372068B2 (en) 2008-10-21 2013-02-12 Hermes Innovations, LLC Tissue ablation systems
US8998901B2 (en) 2008-10-21 2015-04-07 Hermes Innovations Llc Endometrial ablation method
US8197476B2 (en) 2008-10-21 2012-06-12 Hermes Innovations Llc Tissue ablation systems
US20100198216A1 (en) * 2009-02-02 2010-08-05 Palanker Daniel V Electro-thermotherapy of tissue using penetrating microelectrode array
US9254168B2 (en) 2009-02-02 2016-02-09 Medtronic Advanced Energy Llc Electro-thermotherapy of tissue using penetrating microelectrode array
US9486283B2 (en) 2009-02-23 2016-11-08 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical device
US20100217255A1 (en) * 2009-02-23 2010-08-26 Salient Surgical Technologies, Inc. Fluid-Assisted Electrosurgical Device and Methods of Use Thereof
US8632533B2 (en) 2009-02-23 2014-01-21 Medtronic Advanced Energy Llc Fluid-assisted electrosurgical device
US9439735B2 (en) 2009-06-08 2016-09-13 MRI Interventions, Inc. MRI-guided interventional systems that can track and generate dynamic visualizations of flexible intrabody devices in near real time
US9259290B2 (en) 2009-06-08 2016-02-16 MRI Interventions, Inc. MRI-guided surgical systems with proximity alerts
US20100312094A1 (en) * 2009-06-08 2010-12-09 Michael Guttman Mri-guided surgical systems with preset scan planes
US20100312096A1 (en) * 2009-06-08 2010-12-09 Michael Guttman Mri-guided interventional systems that can track and generate dynamic visualizations of flexible intrabody devices in near real time
US8396532B2 (en) 2009-06-16 2013-03-12 MRI Interventions, Inc. MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time
US8886288B2 (en) 2009-06-16 2014-11-11 MRI Interventions, Inc. MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time
US8825133B2 (en) 2009-06-16 2014-09-02 MRI Interventions, Inc. MRI-guided catheters
US8768433B2 (en) 2009-06-16 2014-07-01 MRI Interventions, Inc. MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time
US8369930B2 (en) 2009-06-16 2013-02-05 MRI Interventions, Inc. MRI-guided devices and MRI-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time
US20100317962A1 (en) * 2009-06-16 2010-12-16 Jenkins Kimble L MRI-Guided Devices and MRI-Guided Interventional Systems that can Track and Generate Dynamic Visualizations of the Devices in near Real Time
US9345541B2 (en) 2009-09-08 2016-05-24 Medtronic Advanced Energy Llc Cartridge assembly for electrosurgical devices, electrosurgical unit and methods of use thereof
US20110125146A1 (en) * 2009-09-08 2011-05-26 Salient Surgical Technologies, Inc. Cartridge Assembly For Electrosurgical Devices, Electrosurgical Unit And Methods Of Use Thereof
US9867703B2 (en) 2009-10-01 2018-01-16 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
US9204964B2 (en) 2009-10-01 2015-12-08 Kardium Inc. Medical device, kit and method for constricting tissue or a bodily orifice, for example, a mitral valve
US8715278B2 (en) 2009-11-11 2014-05-06 Minerva Surgical, Inc. System for endometrial ablation utilizing radio frequency
US20110112523A1 (en) * 2009-11-11 2011-05-12 Minerva Surgical, Inc. Systems, methods and devices for endometrial ablation utilizing radio frequency
US9636171B2 (en) 2009-11-13 2017-05-02 Minerva Surgical, Inc. Methods and systems for endometrial ablation utilizing radio frequency
US8821486B2 (en) 2009-11-13 2014-09-02 Hermes Innovations, LLC Tissue ablation systems and methods
US9289257B2 (en) 2009-11-13 2016-03-22 Minerva Surgical, Inc. Methods and systems for endometrial ablation utilizing radio frequency
US20110118718A1 (en) * 2009-11-13 2011-05-19 Minerva Surgical, Inc. Methods and systems for endometrial ablation utilizing radio frequency
US8529562B2 (en) 2009-11-13 2013-09-10 Minerva Surgical, Inc Systems and methods for endometrial ablation
US9592090B2 (en) 2010-03-11 2017-03-14 Medtronic Advanced Energy Llc Bipolar electrosurgical cutter with position insensitive return electrode contact
US9486281B2 (en) 2010-04-13 2016-11-08 Sentreheart, Inc. Methods and devices for accessing and delivering devices to a heart
US9333027B2 (en) * 2010-05-28 2016-05-10 Medtronic Advanced Energy Llc Method of producing an electrosurgical device
US9138289B2 (en) 2010-06-28 2015-09-22 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US9895191B2 (en) 2010-06-28 2018-02-20 Medtronic Advanced Energy Llc Electrode sheath for electrosurgical device
US8920417B2 (en) 2010-06-30 2014-12-30 Medtronic Advanced Energy Llc Electrosurgical devices and methods of use thereof
US9445858B2 (en) 2010-06-30 2016-09-20 Medtronic Advanced Energy Llc Bipolar electrosurgical device
US8906012B2 (en) 2010-06-30 2014-12-09 Medtronic Advanced Energy Llc Electrosurgical devices with wire electrode
US8956348B2 (en) 2010-07-21 2015-02-17 Minerva Surgical, Inc. Methods and systems for endometrial ablation
US8940002B2 (en) 2010-09-30 2015-01-27 Kardium Inc. Tissue anchor system
US9023040B2 (en) 2010-10-26 2015-05-05 Medtronic Advanced Energy Llc Electrosurgical cutting devices
US9510897B2 (en) 2010-11-05 2016-12-06 Hermes Innovations Llc RF-electrode surface and method of fabrication
US9526577B2 (en) 2010-11-12 2016-12-27 Covidien Lp Apparatus, system and method for performing an electrosurgical procedure
US9119647B2 (en) * 2010-11-12 2015-09-01 Covidien Lp Apparatus, system and method for performing an electrosurgical procedure
US20120123403A1 (en) * 2010-11-12 2012-05-17 Vivant Medical, Inc. Apparatus, System and Method for Performing an Electrosurgical Procedure
US9486273B2 (en) 2011-01-21 2016-11-08 Kardium Inc. High-density electrode-based medical device system
US9492227B2 (en) 2011-01-21 2016-11-15 Kardium Inc. Enhanced medical device for use in bodily cavities, for example an atrium
US9492228B2 (en) 2011-01-21 2016-11-15 Kardium Inc. Enhanced medical device for use in bodily cavities, for example an atrium
US9675401B2 (en) 2011-01-21 2017-06-13 Kardium Inc. Enhanced medical device for use in bodily cavities, for example an atrium
US9526573B2 (en) 2011-01-21 2016-12-27 Kardium Inc. Enhanced medical device for use in bodily cavities, for example an atrium
US9480525B2 (en) 2011-01-21 2016-11-01 Kardium, Inc. High-density electrode-based medical device system
US9452016B2 (en) 2011-01-21 2016-09-27 Kardium Inc. Catheter system
US9427281B2 (en) 2011-03-11 2016-08-30 Medtronic Advanced Energy Llc Bronchoscope-compatible catheter provided with electrosurgical device
US9072511B2 (en) 2011-03-25 2015-07-07 Kardium Inc. Medical kit for constricting tissue or a bodily orifice, for example, a mitral valve
US20130066308A1 (en) * 2011-08-31 2013-03-14 Jaime Landman Ablation-based therapy for bladder pathologies
US9750565B2 (en) 2011-09-30 2017-09-05 Medtronic Advanced Energy Llc Electrosurgical balloons
US8870864B2 (en) 2011-10-28 2014-10-28 Medtronic Advanced Energy Llc Single instrument electrosurgery apparatus and its method of use
USD777925S1 (en) 2012-01-20 2017-01-31 Kardium Inc. Intra-cardiac procedure device
USD777926S1 (en) 2012-01-20 2017-01-31 Kardium Inc. Intra-cardiac procedure device
US9693832B2 (en) 2012-05-21 2017-07-04 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US9017320B2 (en) 2012-05-21 2015-04-28 Kardium, Inc. Systems and methods for activating transducers
US9198592B2 (en) 2012-05-21 2015-12-01 Kardium Inc. Systems and methods for activating transducers
US9572509B2 (en) 2012-05-21 2017-02-21 Kardium Inc. Systems and methods for activating transducers
US9445862B2 (en) 2012-05-21 2016-09-20 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US9259264B2 (en) 2012-05-21 2016-02-16 Kardium Inc. Systems and methods for activating transducers
US9439713B2 (en) 2012-05-21 2016-09-13 Kardium Inc. Systems and methods for activating transducers
US9888972B2 (en) 2012-05-21 2018-02-13 Kardium Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US9532831B2 (en) 2012-05-21 2017-01-03 Kardium Inc. Systems and methods for activating transducers
US9017321B2 (en) 2012-05-21 2015-04-28 Kardium, Inc. Systems and methods for activating transducers
US9011423B2 (en) 2012-05-21 2015-04-21 Kardium, Inc. Systems and methods for selecting, activating, or selecting and activating transducers
US9226792B2 (en) 2012-06-12 2016-01-05 Medtronic Advanced Energy Llc Debridement device and method
US9901394B2 (en) 2013-04-04 2018-02-27 Hermes Innovations Llc Medical ablation system and method of making
US20150066016A1 (en) * 2013-09-05 2015-03-05 Mitragen, Inc. Valve treatment devices, systems, and methods
US9907608B2 (en) * 2013-09-05 2018-03-06 Mitragen, Inc. Valve treatment devices, systems, and methods
US20150066015A1 (en) * 2013-09-05 2015-03-05 Mitragen, Inc. Valve treatment devices, systems, and methods
US9649125B2 (en) 2013-10-15 2017-05-16 Hermes Innovations Llc Laparoscopic device
US9931134B2 (en) 2017-07-05 2018-04-03 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions

Also Published As

Publication number Publication date Type
US8801707B2 (en) 2014-08-12 grant
US20150005694A1 (en) 2015-01-01 application
ES2308505T3 (en) 2008-12-01 grant
US20120316488A1 (en) 2012-12-13 application
EP1750605B1 (en) 2012-03-07 grant
JP2007537011A (en) 2007-12-20 application
WO2005112812A1 (en) 2005-12-01 application
EP1750605A1 (en) 2007-02-14 application
CA2569701A1 (en) 2005-12-01 application

Similar Documents

Publication Publication Date Title
US8486063B2 (en) Ablation catheter
US6241727B1 (en) Ablation catheter system having circular lesion capabilities
US7008418B2 (en) Magnetically assisted pulmonary vein isolation
US6245064B1 (en) Circumferential ablation device assembly
US7819866B2 (en) Ablation catheter and electrode
US6663625B1 (en) Radio-frequency based catheter system and hollow co-axial cable for ablation of body tissues
US6752805B2 (en) Surgical ablation probe for forming a circumferential lesion
US6849075B2 (en) Cardiac ablation devices and methods
US6245067B1 (en) Ablation device and methods having perpendicular electrodes
US20050090817A1 (en) Bendable endoscopic bipolar device
US6290699B1 (en) Ablation tool for forming lesions in body tissue
US20050065509A1 (en) Flat electrode arrays for generating flat lesions
US7487780B2 (en) Sub-xyphoid method for ablating cardiac tissue
US7192427B2 (en) Apparatus and method for assessing transmurality of a tissue ablation
US20030163128A1 (en) Tissue ablation system with a sliding ablating device and method
US7850685B2 (en) Ablation catheter
US20080281312A1 (en) Ablation Therapy System and Method for Treating Continuous Atrial Fibrillation
US6907297B2 (en) Expandable intracardiac return electrode and method of use
US20050251131A1 (en) Circumferential ablation device assembly
US6905498B2 (en) Transmural ablation device with EKG sensor and pacing electrode
US20120143177A1 (en) Catheter Systems for Cardiac Arrhythmia Ablation
US20080097139A1 (en) Systems and methods for treating lung tissue
US20100268217A1 (en) Vessel sealing device and methods
US20030069575A1 (en) Tissue ablation system with a sliding ablating device and method
US6241726B1 (en) Catheter system having a tip section with fixation means

Legal Events

Date Code Title Description
AS Assignment

Owner name: MEDTRONIC, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FRANCISCHELLI, DAVID E.;STEWART, MARK T.;SKARDA, JAMES R.;REEL/FRAME:017011/0849;SIGNING DATES FROM 20050824 TO 20050908