US20050136009A1 - Pharmaceutical compositions - Google Patents
Pharmaceutical compositions Download PDFInfo
- Publication number
- US20050136009A1 US20050136009A1 US10/967,719 US96771904A US2005136009A1 US 20050136009 A1 US20050136009 A1 US 20050136009A1 US 96771904 A US96771904 A US 96771904A US 2005136009 A1 US2005136009 A1 US 2005136009A1
- Authority
- US
- United States
- Prior art keywords
- metered dose
- dose inhaler
- formulation
- valve
- inhaler according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Definitions
- a certain minimum level of ethanol is preferred to provide consistent and predictable delivery of the drug from a metered dose dispenser. This minimum level is about 1 weight percent of the total formulation, that results in a marginally acceptable drug delivery. Increased amounts of ethanol generally improve drug delivery characteristics. However, to prevent drug crystal growth in the formulation, it is preferred to limit the concentration of ethanol. Experimental data indicate that the ratio of the weight of Mometasone Furoate to the weight of ethanol is important in preventing particle size increases.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/967,719 US20050136009A1 (en) | 2003-10-20 | 2004-10-18 | Pharmaceutical compositions |
US11/940,046 US20080064674A1 (en) | 2003-10-20 | 2007-11-14 | Pharmaceutical Compositions |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51272503P | 2003-10-20 | 2003-10-20 | |
US10/967,719 US20050136009A1 (en) | 2003-10-20 | 2004-10-18 | Pharmaceutical compositions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/940,046 Continuation US20080064674A1 (en) | 2003-10-20 | 2007-11-14 | Pharmaceutical Compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
US20050136009A1 true US20050136009A1 (en) | 2005-06-23 |
Family
ID=34549219
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/967,719 Abandoned US20050136009A1 (en) | 2003-10-20 | 2004-10-18 | Pharmaceutical compositions |
US11/940,046 Abandoned US20080064674A1 (en) | 2003-10-20 | 2007-11-14 | Pharmaceutical Compositions |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/940,046 Abandoned US20080064674A1 (en) | 2003-10-20 | 2007-11-14 | Pharmaceutical Compositions |
Country Status (13)
Country | Link |
---|---|
US (2) | US20050136009A1 (es) |
EP (1) | EP1684717A2 (es) |
JP (2) | JP2007509147A (es) |
KR (1) | KR20060106823A (es) |
CN (1) | CN1870976A (es) |
AU (1) | AU2004285447A1 (es) |
BR (1) | BRPI0415707A (es) |
CA (1) | CA2542530A1 (es) |
MX (1) | MXPA06004331A (es) |
NO (1) | NO20062279L (es) |
SG (1) | SG147453A1 (es) |
WO (1) | WO2005041931A2 (es) |
ZA (1) | ZA200603121B (es) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070203104A1 (en) * | 2006-02-09 | 2007-08-30 | Chaudhry Saeed M | Pharmaceutical Formulations |
US20090022671A1 (en) * | 2004-01-21 | 2009-01-22 | Schering Corporation | Treatment methods |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE384001T1 (de) * | 2002-08-27 | 2008-02-15 | Schering Corp | Verfahren zur herstellung von dosierinhalatorformulierungen |
US20080253970A1 (en) * | 2007-02-09 | 2008-10-16 | Schering Corporation | Stable Pharmaceutical Drug Products |
MX2009008572A (es) * | 2007-02-09 | 2009-10-19 | Schering Corp | Aerosoles estables con farmaco de grado farmaceutico. |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030050290A1 (en) * | 1999-03-03 | 2003-03-13 | Hassan Ian Francis | Combination of formoterol and mometasone furoate for asthma |
US20030089369A1 (en) * | 1998-11-25 | 2003-05-15 | Chiesi Farmaceutici S.P.A. | Pressurised metered dose inhalers (MDI) |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE555319A (es) * | 1956-03-21 | 1900-01-01 | ||
US2885427A (en) * | 1956-11-15 | 1959-05-05 | Dow Chemical Co | Fluorination of trichloroethylene |
US3320125A (en) * | 1964-04-28 | 1967-05-16 | Merck & Co Inc | Inhalation aerosol composition |
US3261748A (en) * | 1964-07-17 | 1966-07-19 | Dow Chemical Co | 1,1,1,2-tetrafluoroethane anesthetic |
GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
NL7708731A (nl) * | 1976-08-13 | 1978-02-15 | Montedison Spa | Werkwijze voor de bereiding van nieuwe drijf- middelsamenstellingen voor aerosolen. |
US4129603A (en) * | 1978-02-07 | 1978-12-12 | Imperial Chemical Industries Limited | Manufacture of halogenated compounds |
US4311863A (en) * | 1980-06-11 | 1982-01-19 | E. I. Du Pont De Nemours & Company | Process for the manufacture of 1,1,1,2-tetrafluoroethane |
US4851595A (en) * | 1987-07-07 | 1989-07-25 | E. I. Du Pont De Nemours And Company | Liquid phase halogen exchange process for the manufacture of 1,1,1,2-tetrafluoroethane |
US4967024A (en) * | 1988-06-23 | 1990-10-30 | E. I. Du Pont De Nemours And Company | Catalyzed hydrofluorination process |
US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
DE3905726A1 (de) * | 1989-02-24 | 1990-08-30 | Hoechst Ag | Druckgaspackung und treibmittel fuer aerosole |
DE4003270A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
US5118494A (en) * | 1990-03-23 | 1992-06-02 | Minnesota Mining And Manufacturing Company | Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations |
US6006745A (en) * | 1990-12-21 | 1999-12-28 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
DE69232818T2 (de) * | 1991-06-10 | 2003-06-18 | Schering Corp., Kenilworth | Fluorchlorkohlenwasserstofffreie Aerosolformulierungen |
ES2084360T3 (es) * | 1991-06-10 | 1996-05-01 | Schering Corp | Formulaciones de aerosoles exentas de clorofluorocarbonos. |
US5736124A (en) * | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
US5653962A (en) * | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
IL104068A (en) * | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
US5674471A (en) * | 1991-12-12 | 1997-10-07 | Glaxo Group Limited | Aerosol formulations containing P134a and salbutamol |
US5658549A (en) * | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
US7101534B1 (en) * | 1991-12-18 | 2006-09-05 | 3M Innovative Properties Company | Suspension aerosol formulations |
EP1086688B1 (en) * | 1991-12-18 | 2004-03-03 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
CZ148094A3 (en) * | 1991-12-18 | 1994-12-15 | Schering Corp | Method of removing residual additives from elastomeric products |
US7105152B1 (en) * | 1991-12-18 | 2006-09-12 | 3M Innovative Properties Company | Suspension aerosol formulations |
US5202110A (en) * | 1992-01-22 | 1993-04-13 | Virginia Commonwealth University | Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants |
GB9612297D0 (en) * | 1996-06-11 | 1996-08-14 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
GB2314336A (en) * | 1996-06-18 | 1997-12-24 | Bespak Plc | Method of cleaning or purifying elastomers and elastomeric articles which are intended for medical or pharmaceutical use |
US6068832A (en) * | 1996-08-29 | 2000-05-30 | Schering Corporation | Chlorofluorocarbon-free mometasone furoate aerosol formulations |
AU719079B2 (en) * | 1996-08-29 | 2000-05-04 | Merck Sharp & Dohme Corp. | Chlorofluorocarbon-free mometasone furoate aerosol formulations |
AU2001278115A1 (en) * | 2000-08-04 | 2002-02-18 | Longwood Pharmaceutical Research, Inc. | Formulations of mometasone and a bronchodilator for pulmonary administration |
EP1241113A1 (en) * | 2001-03-12 | 2002-09-18 | CHIESI FARMACEUTICI S.p.A. | Inhaler with means for improving chemical stability of medicinal aerosol solution contained therein |
WO2002100928A1 (en) * | 2001-06-12 | 2002-12-19 | North Carolina State University | Barrier coatings for elastomeric materials |
TWI324934B (en) * | 2001-08-28 | 2010-05-21 | Schering Corp | Pharmaceutical compositions for the treatment of asthma |
EP1461101A4 (en) * | 2001-12-07 | 2005-02-09 | Glaxo Group Ltd | DOSAGE VALVE, PHARMACEUTICAL AGENT AEROSOL-DOSER, AND METHODS THEREOF |
ATE353231T1 (de) * | 2002-08-23 | 2007-02-15 | Schering Corp | Pharmazeutische zusammensetzungen |
ATE384001T1 (de) * | 2002-08-27 | 2008-02-15 | Schering Corp | Verfahren zur herstellung von dosierinhalatorformulierungen |
US20080253970A1 (en) * | 2007-02-09 | 2008-10-16 | Schering Corporation | Stable Pharmaceutical Drug Products |
-
2004
- 2004-10-18 WO PCT/US2004/034359 patent/WO2005041931A2/en active Application Filing
- 2004-10-18 CN CNA2004800309749A patent/CN1870976A/zh active Pending
- 2004-10-18 EP EP04795506A patent/EP1684717A2/en not_active Ceased
- 2004-10-18 KR KR1020067007514A patent/KR20060106823A/ko not_active Application Discontinuation
- 2004-10-18 AU AU2004285447A patent/AU2004285447A1/en not_active Abandoned
- 2004-10-18 MX MXPA06004331A patent/MXPA06004331A/es unknown
- 2004-10-18 US US10/967,719 patent/US20050136009A1/en not_active Abandoned
- 2004-10-18 BR BRPI0415707-9A patent/BRPI0415707A/pt not_active IP Right Cessation
- 2004-10-18 CA CA002542530A patent/CA2542530A1/en not_active Abandoned
- 2004-10-18 SG SG200807804-0A patent/SG147453A1/en unknown
- 2004-10-18 JP JP2006536692A patent/JP2007509147A/ja active Pending
-
2006
- 2006-04-19 ZA ZA200603121A patent/ZA200603121B/en unknown
- 2006-05-19 NO NO20062279A patent/NO20062279L/no not_active Application Discontinuation
-
2007
- 2007-10-12 JP JP2007267112A patent/JP2008024721A/ja active Pending
- 2007-11-14 US US11/940,046 patent/US20080064674A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030089369A1 (en) * | 1998-11-25 | 2003-05-15 | Chiesi Farmaceutici S.P.A. | Pressurised metered dose inhalers (MDI) |
US20030050290A1 (en) * | 1999-03-03 | 2003-03-13 | Hassan Ian Francis | Combination of formoterol and mometasone furoate for asthma |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090022671A1 (en) * | 2004-01-21 | 2009-01-22 | Schering Corporation | Treatment methods |
US20070203104A1 (en) * | 2006-02-09 | 2007-08-30 | Chaudhry Saeed M | Pharmaceutical Formulations |
Also Published As
Publication number | Publication date |
---|---|
US20080064674A1 (en) | 2008-03-13 |
JP2008024721A (ja) | 2008-02-07 |
CN1870976A (zh) | 2006-11-29 |
NO20062279L (no) | 2006-05-19 |
WO2005041931A2 (en) | 2005-05-12 |
EP1684717A2 (en) | 2006-08-02 |
AU2004285447A1 (en) | 2005-05-12 |
KR20060106823A (ko) | 2006-10-12 |
WO2005041931A3 (en) | 2006-04-06 |
JP2007509147A (ja) | 2007-04-12 |
MXPA06004331A (es) | 2006-06-05 |
BRPI0415707A (pt) | 2006-12-19 |
SG147453A1 (en) | 2008-11-28 |
CA2542530A1 (en) | 2005-05-12 |
ZA200603121B (en) | 2007-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: SCHERING CORPORATION, NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:BERRY, JULIANNE;SHERWOOD, JILL K.;CHAUDHRY, SAEED;AND OTHERS;REEL/FRAME:015911/0182;SIGNING DATES FROM 20041020 TO 20041025 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |