US20050119756A1 - Disposable articulated spacing device for surgical treatment of joints of the human body - Google Patents

Disposable articulated spacing device for surgical treatment of joints of the human body Download PDF

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Publication number
US20050119756A1
US20050119756A1 US11/029,793 US2979305A US2005119756A1 US 20050119756 A1 US20050119756 A1 US 20050119756A1 US 2979305 A US2979305 A US 2979305A US 2005119756 A1 US2005119756 A1 US 2005119756A1
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United States
Prior art keywords
pre
method defined
formed
joint
member
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Abandoned
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US11/029,793
Inventor
Renzo Soffiati
Claudio Castelli
Giovanni Faccioli
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Tecres SpA
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Tecres SpA
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Publication date
Family has litigation
Priority to ITVI20000025 priority Critical patent/ITVI20000025U1/en
Priority to ITVI2000U000025 priority
Priority to WOPCT/IB01/00574 priority
Priority to PCT/IB2001/000574 priority patent/WO2001076512A1/en
Application filed by Tecres SpA filed Critical Tecres SpA
Publication of US20050119756A1 publication Critical patent/US20050119756A1/en
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11461146&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20050119756(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/38Joints for elbows or knees
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30672Features concerning an interaction with the environment or a particular use of the prosthesis temporary
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body

Abstract

A disposable articulated spacing device for the treatment of joints of the human body, particularly for temporarily replacing an explanted joint prosthesis, comprises at least one first member able to be secured to a first articulation end and at least one second member able to be secured to the other articulation end, both said members being pre-formed and made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products. The pre-formed members are reciprocally coupled in an articulated manner to maintain a suitable joint space and at least a partial articulation for the time necessary to perform the further implantation of a joint prosthesis. The biologically compatible and porous material is chosen among metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof. The articulated spacing device maintains a suitable space in the joint seat while allowing considerable articulated mobility, and re-establishes suitable conditions of implantation of a new permanent joint prosthesis.

Description

    TECHNICAL FIELD
  • The present invention is generally applicable to surgical treatment of articulations of the human body and in particular relates to a disposable spacing device for temporary replacement of joint prosthesis which have to be explanted due to unsuccessful septic or aseptic implantation of artificial joints.
  • According to the well known surgical “dual stage” method, the above spacing device can be maintained in the joint seat as long as necessary for re-establishing the most favourable conditions of implantation of the new artificial joint prosthesis.
  • BACKGROUND ART
  • It is known how artificial joints, such as knee, hip, heel and elbow joints often have to be removed for various reasons and mainly following local infections after a surgical implant.
  • In such a case, it is not possible to replace immediately the unsuccessful prosthesis with a new one, but the seat of the joint must be treated with suitable antibiotics before a new surgical operation can be performed.
  • In the meantime, the space within the joint must be maintained in order to prevent a reduction in the articular space, retraction of the tissues, atrophying of the joint and loss of muscular elasticity and tone.
  • Spacing devices used in the two-stage implant of artificial joints, for treatment of both the hip and the knee, are known.
  • Italian patent application No. VR95A000072 describes a disposable spacing device for an artificial hip joint, essentially characterized in that it is made of a biocompatible base material of the type used for bone cements.
  • Spacing devices for knee joints which are manually made by the surgeon at the time of the surgical operation are also known, these devices being made from blocks of bone cement of standard shape, optionally containing active constituents.
  • A drawback of these known methods of treatment is that they do not allow the space within the joint to be kept apart in an ergonomically and anatomically correct manner. Moreover, the long time required for preparation increases the difficulties for the surgeon and reduces the probability of success of the operation.
  • In order to overcome these drawbacks, spacing devices have been made using suitable anatomically and ergonomically shaped moulds which are filled with bone cement in situ. However, these known spacing devices do not allow mobilisation of the joint and result in the need for a long rehabilitation after reimplanting the permanent prosthesis.
  • In still other cases, the spacing devices have been obtained by lining a permanent metal prosthesis with bone cement. Although this solution allows a temporary articulation, it is difficult to prepare and in spite of use of cement-lined prostheses requires that such devices are positioned in infected seats, which most of the surgeon consider a worsening infection factor.
  • DISCLOSURE OF THE INVENTION
  • The main object of the present invention is to provide surgeons with a disposable and ready-to-use articulated spacing device, able to be directly implanted in the articulation seat for example of knee, hip, hell or elbow joints in case of replacement of a pre-existing prosthesis which must be removed due to septic or aseptic failures.
  • A further object is to provide a disposable articulated spacing device which allows to maintain a in a healing environment a suitable articular space for the time necessary to successfully re-implant a new permanent prosthesis.
  • A further object is to provide a disposable articulated spacing device which allows correct articulation and an anatomical and ergonomic form of the temporary implant.
  • Yet another object is to provide a disposable articulated spacing device which can be easily implanted and explanted into/from the location of the joint.
  • Yet another object is to provide a disposable articulated spacing device with limited articular friction so as to allow considerable mobility of the joint and improve the quality of life of the patient during hospitalisation.
  • These and other objects which will be more apparent hereinafter are achieved by a disposable articulated spacing device for the temporary replacement of a joint of the human body which, in accordance with claim 1, comprises at least one first member able to be secured to a first articulation end and at least one second member able to be secured to a second articulation end, both said members being pre-formed and entirely made of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products, said pre-formed members being able to be reciprocally coupled in an articulated manner to maintain a suitable joint space and at least partial articulated mobility for the time necessary to perform the further implantation of a new permanent joint prosthesis.
  • Preferably, the above mentioned biologically compatible and porous material is chosen among metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof.
  • The pre-formed members of the device may be previously charged with suitable pharmaceutical and therapeutical products. As alternative, the pre-formed members are initially free of the same products and are added immediately prior of their implantation by contact absorption or by filling of suitable cavities formed on their other surface.
  • Advantageously, the pharmaceutical and therapeutical products may be chosen among medical active principles, antibiotics and radiopacifier and may be added in the pre-formed members.
  • In case that the articulated spacing device replaces a knee joint, the pre-formed members may comprise a femoral member consisting of a body substantially shell-shaped and reproducing the femoral condyles, and tibial members consisting of a prismatic body able to replace the resected tibial flat portion.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • Further features and advantages of the invention will, be more clearly understood in the light of the following detailed description of a disposable articulated spacing device furnished by way of a non-limiting example with the aid of the accompanying drawings, in which:
  • FIG. 1 shows a front view of a first detail of a spacing model according to the invention;
  • FIG. 2 shows a side view of the detail according to FIG. 1;
  • FIG. 3 shows a top view of the detail according to FIG. 1;
  • FIG. 4 shows a front view of another detail of the spacing device according to the invention;
  • FIG. 5 shows a side view of the detail according to FIG. 4;
  • FIG. 6 shows a top view of the detail according to FIG. 4;
  • FIGS. 7 and 8 show perspective views, from the top and bottom, of the detail of the device illustrated in FIGS. 1 to 3;
  • FIGS. 9 and 10 show a side view and a top perspective view of the detail according to FIGS. 4 to 6;
  • FIG. 11 shows a perspective view of the two details of the preceding figures in aligned positions; and
  • FIG. 12 shows a side view of an alternative embodiment of the spacing device according to the invention.
  • DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS
  • With reference to the above mentioned figures, there is shown a disposable articulated spacing device for the temporary replacement of a joint prosthesis explanted from a human body.
  • The articulated spacing device, generally indicated with the reference number 1, comprises at least one first member 2 able to be secured to a first joint end and at last one second member 3 able to be secured to a second joint end.
  • According to the invention, both members 2, 3 are pre-formed and entirely made of a biological compatible and porous material and are mutually coupled in an articulated manner so as to maintain in a healing environment a suitable joint space and at least partial mobility of the joint for the time necessary to permit the further re-implantation of a new permanent joint prosthesis.
  • Preferably, the biological compatible and porous material may be chosen among metals, metallic alloys organo-metals, ceramics, glasses, plastics materials and combinations thereof.
  • Specifically, the above plastics material may be chosen among thermoplastic polymers, such as acrylic resins, polyethylene, polypropylene, thermoformable e.g. by blow moulding or injection moulding.
  • As alternative, the plastics material may be chosen among cold-formable resins curable by means of free radical polymerisation such as acrylic resins and polyesters.
  • In a per se known manner, free radical polymerisation may be accelerated either by suitable chemical catalysts and initiators, such as benzoyl peroxide, or physical accelerators such as ionizing radiation, gamma-rays, UV-rays.
  • In the particularly preferred embodiment the biological compatible and porous material forming the members 2, 3 is a bone-cements, e.g. that used in the Italian patent application no. VR95A000072 filed by the same applicant.
  • The pre-formed members 2, 3 may be previously added with suitable pharmaceutical and therapeutical products chosen among active medical principles, antibiotics and radiopacifiers.
  • In alternative, the pharmaceutical and therapeutical products may be added to the pre-formed members immediately prior of implantation thereof either by direct contact absorption or by filling of suitable cavities formed on their outer surfaces.
  • The pharmaceutical and therapeutical products in the form of liquid solutions may be easily absorbed by the device thanks to the porosity of their basic material and then released after implantation in the joint seat.
  • Advantageously, the pre-formed members 2, 3 may be shaped in different sizes to be correctly adapted to the different patients. Moreover, these members may present anchoring means for their fixation to the joint ends.
  • The embodiment of the spacer device 1 shown in the figures is designed to be inserted in the knee joint.
  • The pre-formed member 2 is a tibial member and the pre-formed member 3 is a femoral member.
  • In particular, the femoral part 3 consists of a first proximal body 4 designed to occupy the space left by an explanted metal prosthesis. Preferably, the body 4 has a shape, in plan view, approximately in the form of a “U” or horseshoe, with side portions 4′, 4″ and a central recess 5. The external contact surface 6 of the body 4 has a curvature able to reproduce that of the femoral condyles.
  • The tibial member 2 consists of a second proximal body 7 which is approximately prismatic, slightly curved and of suitable thickness. The body 7 also has a shape, in plan view, approximately in the form of a “U” or horseshoe, with a curved internal contact surface 8 and an internal recess 9 so as to simulate the resected tibial flat portion.
  • The contact surfaces 6, 8 of members 2, 3 are formed so as to allow a roto-translatory movement during the flexing/extending movement of the limb.
  • Moreover, the surfaces 6, 8 may have an excellent surface finish with a low coefficient of friction so as to allow a considerably degree of articular mobility.
  • Both members 2, 3 may be provided with respective projections or rod-shaped distal portions 10, 11 for securing to the respective joint ends, e.g. by means of bone cement.
  • In use, the surgeon initially removes the previous infected joint prosthesis and cleans the articulation space. The surgeon further chooses the suitable spacing device with pre-formed members 2, 3 adapted of the size of the patient.
  • If the pre-formed members are already previously charged with active principles and pharmaceutical and therapeutical products upon formation thereof, the surgeon implants them taking care that they are fixedly secured to the joint ends and are mutually articulately coupled to allow at least partial mobilisation of the joint.
  • If on the contrary the members are not yet charged as above, the surgeon either impinges them in a solution of active principles or fills with them several outer cavities formed in situ or pre-shaped on their outer surfaces, and finally implants the members in the articulation seat, securing them to the joint ends through appropriate anchoring means or bone cement.

Claims (17)

1-17. (canceled)
18. A medical method for temporarily replacing an explanted permanent joint prosthesis, comprising: providing a preformed disposable articulated spacing device including at least one first pre-formed member and at least one second pre-formed member, both the pre-formed members being made entirely of biological compatible and porous material suitable to be added with pharmaceutical and therapeutical products, said pre-formed members being initially free of pharmaceutical and therapeutical products, said pre-formed members having a porosity in their base material or suitable cavities formed on their outer surfaces adapted to be filled with pharmaceutical and therapeutical products;
securing said first pre-formed member to a first articulation end of a joint of a patient;
securing said second pre-formed member to a second articulation end of the patient's joint;
reciprocally coupling said first pre-formed member and said second pre-formed member to one another in an articulated manner at the patient's joint to maintain a suitable joint space and at least partial articulated mobility for a time necessary to perform implantation of a new permanent joint prosthesis; and
adding at least one pharmaceutical or therapeutical product in the form of a liquid solution to the pre-formed members immediately prior of implantation thereof.
19. The method defined in claim 18 wherein the adding of at least one pharmaceutical or therapeutical product in the form of a liquid solution includes direct contact and absorption.
20. The method defined in claim 18 wherein the adding of at least one pharmaceutical or therapeutical product in the form of a liquid solution includes insertion thereof in said suitable cavities in said pre-formed members.
21. The method defined in claim 18, wherein said biologically compatible and porous material is selected from the group consisting of metals, metallic alloys, organo-metals, ceramics, glasses, plastics materials, bone cements and combinations thereof.
22. The method defined in claim 21, wherein said plastics materials are selected from the group consisting of thermoplastic polymers, acrylic resins, polyethylene, polypropylene, and resins thermoformable by blow molding or injection molding.
23. The method defined in claim 21, wherein said plastics materials are cold-formable resins.
24. The method defined in claim 18, wherein said biological compatible and porous material is a bone cement.
25. The method defined in claim 18, wherein said pharmaceutical and therapeutical products are selected from the group consisting of active medical principals, antibiotics and radiopacifiers.
26. The method defined in claim 18, wherein said pre-formed members are configured so as to allow a roto-translatory movement of condyles during a flexing/extending movement of a limb.
27. The method defined in claim 26, wherein said pre-formed members have respective contact surfaces with a minimum coefficient of friction so as to allow a high degree of articular mobility.
28. The method defined in claim 18, wherein said pre-formed members are shaped in a respective size to be adapted to the respective patient.
29. The method defined in claim 18, wherein said pre-formed members are provided with anchoring means for attachment thereof to the articulation ends.
30. The method defined in claim 29, wherein said anchoring means consist of respective projections or rod-shaped distal portions.
31. The method defined in claim 18, wherein said pre-formed members are secured to said joint ends with bone cement.
32. The method defined in claim 18, particularly for a knee joint, wherein said pre-formed members comprise a femoral member and a tibial member.
33. The method defined in claim 32, wherein said femoral member consists of a first body substantially in the shape of a shell to reproduce femoral condyles and that said tibial member consists of a second body of substantially prismatic shape with predetermined thickness to replace a resected tibial flat portion.
US11/029,793 2000-04-07 2005-01-05 Disposable articulated spacing device for surgical treatment of joints of the human body Abandoned US20050119756A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITVI20000025 ITVI20000025U1 (en) 2000-04-07 2000-04-07 Temporary spacing device for the surgical treatment of the knee
ITVI2000U000025 2000-04-07
WOPCT/IB01/00574 2001-04-09
PCT/IB2001/000574 WO2001076512A1 (en) 2000-04-07 2001-04-09 Disposable articulated spacing device for surgical treatment of joints of the human body

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US10/239,813 Abandoned US20040054417A1 (en) 2000-04-07 2001-04-09 Disposable articulated spacing device for surgical treatment of joints of the human body
US10/963,123 Active 2022-04-17 US7601176B2 (en) 2000-04-07 2004-10-12 Disposable articulated spacing device for surgical treatment of joints of the human body
US11/029,793 Abandoned US20050119756A1 (en) 2000-04-07 2005-01-05 Disposable articulated spacing device for surgical treatment of joints of the human body

Family Applications Before (2)

Application Number Title Priority Date Filing Date
US10/239,813 Abandoned US20040054417A1 (en) 2000-04-07 2001-04-09 Disposable articulated spacing device for surgical treatment of joints of the human body
US10/963,123 Active 2022-04-17 US7601176B2 (en) 2000-04-07 2004-10-12 Disposable articulated spacing device for surgical treatment of joints of the human body

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US (3) US20040054417A1 (en)
EP (2) EP1274374B1 (en)
JP (2) JP4491181B2 (en)
CN (1) CN1216585C (en)
AT (1) AT416728T (en)
AU (1) AU780792B2 (en)
CA (1) CA2404771C (en)
DE (1) DE60136920D1 (en)
DK (1) DK1274374T3 (en)
ES (1) ES2319100T3 (en)
IT (1) ITVI20000025U1 (en)
MX (1) MXPA02009918A (en)
PT (1) PT1274374E (en)
WO (1) WO2001076512A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070222114A1 (en) * 2006-03-23 2007-09-27 Ziran Bruce H Method of forming a temporary implant and mold assembly for same
US20090069899A1 (en) * 2007-09-11 2009-03-12 Howmedica Osteonics Corp. Antibiotic bone cement spacer
US20100102484A1 (en) * 2008-10-29 2010-04-29 Sean Haney Spacer molds with releasable securement
US20100297276A1 (en) * 2007-12-07 2010-11-25 Zimmer, Inc. Spacer Mold and Methods Therefor
WO2013156743A1 (en) * 2012-04-19 2013-10-24 Teknimed Spacer implant for the temporary replacement of a knee prosthesis

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7537664B2 (en) * 2002-11-08 2009-05-26 Howmedica Osteonics Corp. Laser-produced porous surface
JP2006015042A (en) * 2004-07-05 2006-01-19 Kazumasa Itokazu Porous ceramic spacer containing medicine
US20060147332A1 (en) * 2004-12-30 2006-07-06 Howmedica Osteonics Corp. Laser-produced porous structure
WO2006110896A2 (en) * 2005-04-12 2006-10-19 The University Of Vermont And State Agriculture College Knee prosthesis
US8728387B2 (en) 2005-12-06 2014-05-20 Howmedica Osteonics Corp. Laser-produced porous surface
US8070821B2 (en) * 2005-12-27 2011-12-06 Howmedica Osteonics Corp. Hybrid femoral implant
FR2898039B1 (en) * 2006-03-03 2008-06-27 Ceravic Sas Soc Par Actions Si temporary implant comprising two assets.
US8333805B2 (en) * 2006-03-20 2012-12-18 Howmedica Osteonics Corp. Composite joint implant
US8147861B2 (en) * 2006-08-15 2012-04-03 Howmedica Osteonics Corp. Antimicrobial implant
WO2009014718A1 (en) 2007-07-24 2009-01-29 Porex Corporation Porous laser sintered articles
WO2009108960A2 (en) * 2008-02-25 2009-09-03 Linares Medical Devices, Llc Artificial wear resistant plug for mounting to existing joint bone
DE102008040784B3 (en) * 2008-07-28 2009-12-31 Friedrich-Alexander-Universität Erlangen-Nürnberg Femur component for spacer of knee joint of patient, has tibia sided area comprising tibia sided surfaces for cooperating with tibia component of spacer, and clamping mechanism for clamping part of thigh bone
CA2729866C (en) 2008-08-06 2015-10-20 Tecres S.P.A. Modular spacer device for the treatment of prosthesis infections
US20100185298A1 (en) * 2009-01-22 2010-07-22 Stone Kenneth D Acetabular Spacer for Treatment of Hip Sepsis
US8454706B2 (en) 2009-02-25 2013-06-04 Brian C. de Beaubien Antibiotic delivery system and method for treating an infected synovial joint during re-implantation of an orthopedic prosthesis
DE202009012964U1 (en) 2009-09-28 2010-03-18 Medizinische Hochschule Hannover - Anstalt des öffentlichen Rechts Mold for a cement bulk head for the hip arthroplasty
US8727203B2 (en) 2010-09-16 2014-05-20 Howmedica Osteonics Corp. Methods for manufacturing porous orthopaedic implants
US9597090B2 (en) 2010-12-17 2017-03-21 Zimmer, Inc. Cut guide attachment for use in tibial prosthesis systems
US8603101B2 (en) 2010-12-17 2013-12-10 Zimmer, Inc. Provisional tibial prosthesis system
US20130060344A1 (en) * 2011-09-07 2013-03-07 Biomet Manufacturing Corp. Femoral component with reinforced articulating surface
PT2758004E (en) * 2011-09-19 2015-11-03 Tecres Spa Temporary modular spacer device for joints of the human body
MX349090B (en) * 2011-09-19 2017-07-10 Tecres Spa Modular spacer device for the treatment of infections of the prosthesis of the human limbs.
US9198759B2 (en) 2011-09-19 2015-12-01 Tecres S.P.A. Modular spacer device for the treatment of infections of prosthesis of human limbs
EP3241527A1 (en) 2011-11-21 2017-11-08 Zimmer, Inc. Tibial baseplate with asymmetric placement of fixation structures
CN104203160B (en) 2012-01-30 2016-05-11 捷迈有限公司 A shank asymmetric knee prosthesis
US9364896B2 (en) 2012-02-07 2016-06-14 Medical Modeling Inc. Fabrication of hybrid solid-porous medical implantable devices with electron beam melting technology
US9180010B2 (en) 2012-04-06 2015-11-10 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
US9135374B2 (en) 2012-04-06 2015-09-15 Howmedica Osteonics Corp. Surface modified unit cell lattice structures for optimized secure freeform fabrication
JP6165861B2 (en) * 2012-08-09 2017-07-19 ウォルカー、ピーター、スタンリー Exchange replacement function of all the artificial knee joint of the anterior cruciate ligament
DE102013205156B4 (en) 2013-03-22 2015-02-12 Heraeus Medical Gmbh Kniespacer for temporarily replacing an artificial knee joint
US9278002B2 (en) * 2013-06-07 2016-03-08 Gregory Merrell Elbow antibiotic spacer implant
DE102013011296A1 (en) 2013-07-08 2015-01-08 Heraeus Medical Gmbh A two-part articulating Gelenkspacer and process for its preparation
DE102013213831B4 (en) 2013-07-15 2015-01-29 Heraeus Medical Gmbh Kniespacer for temporarily replacing an artificial knee joint
US10265179B2 (en) 2013-09-09 2019-04-23 Cossington Limited Adjustable modular spacer device for the articulation of the knee
US9622868B2 (en) 2014-04-28 2017-04-18 Biomet Manufacturing, Llc Convertible pre-partial knee replacement
KR20170063737A (en) * 2014-09-23 2017-06-08 테크레스 에스.피.에이. Constrained prosthesis for the knee joint
WO2016087561A1 (en) * 2014-12-05 2016-06-09 Ceramtec Gmbh Ceramic spacer for the two-sided replacement of implants in shoulder, knee, and hip as a result of infections
FR3032347A1 (en) * 2015-02-05 2016-08-12 Assist Publique - Hopitaux De Paris Total knee prosthesis with friction torque ceramic on ceramic and ceramic movable platen.
EP3352708A1 (en) 2015-09-21 2018-08-01 Zimmer, Inc. Prosthesis system including tibial bearing component
BR112018006652A2 (en) * 2015-10-07 2018-10-23 Ceram Gmbh Knee endoprosthesis for replacing at least parts of the knee joint
US10022233B1 (en) * 2017-12-04 2018-07-17 Duke University Orthopedic implant for sustained drug release

Citations (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462120A (en) * 1981-07-06 1984-07-31 Andre Rambert Total knee prosthesis
US5123927A (en) * 1990-12-05 1992-06-23 University Of British Columbia Method and apparatus for antibiotic knee prothesis
US5366508A (en) * 1986-01-28 1994-11-22 Thm Biomedical, Inc Apparatus for biodegradable, osteogenic, bone graft substitute device
US5522895A (en) * 1993-07-23 1996-06-04 Rice University Biodegradable bone templates
US5650108A (en) * 1994-10-06 1997-07-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Porous bone replacement materials
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US5980573A (en) * 1997-05-12 1999-11-09 Shaffner; Richard L. Method and apparatus for fighting infection and maintaining joint spacing in a prosthesis implant area
US6007580A (en) * 1995-06-13 1999-12-28 Bionx Implants Oy Joint prosthesis
US6027743A (en) * 1994-06-03 2000-02-22 Stryker Corporation Manufacture of autogenous replacement body parts
US6113640A (en) * 1997-06-11 2000-09-05 Bionx Implants Oy Reconstructive bioabsorbable joint prosthesis
US6206927B1 (en) * 1999-04-02 2001-03-27 Barry M. Fell Surgically implantable knee prothesis
US6210436B1 (en) * 1998-05-18 2001-04-03 Scimed Life Systems Inc. Implantable members for receiving therapeutically useful compositions
US6280475B1 (en) * 1994-09-08 2001-08-28 Stryker Technologies Corporation Hydrogel intervertebral disc nucleus implantation method
US20010018614A1 (en) * 1999-03-16 2001-08-30 Bianchi John R. Implants for orthopedic applications
US6328765B1 (en) * 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US20020013626A1 (en) * 2000-07-19 2002-01-31 Peter Geistlich Bone material and collagen combination for repair of injured joints
US6398814B1 (en) * 1998-09-14 2002-06-04 Bionx Implants Oy Bioabsorbable two-dimensional multi-layer composite device and a method of manufacturing same
US6410044B1 (en) * 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6419709B1 (en) * 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US6454811B1 (en) * 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US6508838B2 (en) * 1997-04-22 2003-01-21 Washington Research Foundation Compositions for medical implantation
US6514286B1 (en) * 1996-12-03 2003-02-04 Osteobiologics, Inc. Biodegradable polymeric film
US20030033021A1 (en) * 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US20040030341A1 (en) * 2001-03-02 2004-02-12 Marcel Aeschlimann Implants, device and method for joining tissue parts
US6719989B1 (en) * 1999-09-08 2004-04-13 Pentax Corporation Sustained release drug carrier, and method of manufacturing sustained release drug carrier
US20040267363A1 (en) * 1999-05-10 2004-12-30 Fell Barry M Surgically implantable knee prosthesis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4033291A1 (en) * 1990-10-19 1992-04-23 Draenert Klaus Material and process for its manufacture
EP0523926A3 (en) * 1991-07-15 1993-12-01 Smith & Nephew Richards Inc Prosthetic implants with bioabsorbable coating
US5344459A (en) * 1991-12-03 1994-09-06 Swartz Stephen J Arthroscopically implantable prosthesis
DE4242889A1 (en) * 1992-12-18 1994-06-23 Merck Patent Gmbh Hohlendoprothesen with bone growth-promoting filling
NZ279442A (en) * 1994-01-26 1998-02-26 Mark A Reiley Bone treatment device; inflatable balloon for insertion into a bone; balloon details
CA2160198C (en) * 1994-10-27 2003-12-30 Michael J. Pappas Prosthesis fixturing device
US5702458A (en) * 1994-12-09 1997-12-30 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Joint prosthesis
JPH0930988A (en) * 1995-07-21 1997-02-04 Sumitomo Osaka Cement Co Ltd Sustained release porous ceramic molding for medicine and its production
IT1278853B1 (en) 1995-09-08 1997-11-28 Tecres Spa Disposable Spacer device for the treatment of hip artoprotesi
DE29703971U1 (en) * 1997-03-05 1998-07-09 Siebel Thomas Dr bone prosthesis
US6419704B1 (en) * 1999-10-08 2002-07-16 Bret Ferree Artificial intervertebral disc replacement methods and apparatus
WO2002016589A2 (en) * 2000-08-21 2002-02-28 Millennium Pharmaceuticals, Inc. Human abc transporter family member and uses thereof

Patent Citations (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4462120A (en) * 1981-07-06 1984-07-31 Andre Rambert Total knee prosthesis
US5366508A (en) * 1986-01-28 1994-11-22 Thm Biomedical, Inc Apparatus for biodegradable, osteogenic, bone graft substitute device
US5123927A (en) * 1990-12-05 1992-06-23 University Of British Columbia Method and apparatus for antibiotic knee prothesis
US5522895A (en) * 1993-07-23 1996-06-04 Rice University Biodegradable bone templates
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US6027743A (en) * 1994-06-03 2000-02-22 Stryker Corporation Manufacture of autogenous replacement body parts
US6280475B1 (en) * 1994-09-08 2001-08-28 Stryker Technologies Corporation Hydrogel intervertebral disc nucleus implantation method
US5650108A (en) * 1994-10-06 1997-07-22 Merck Patent Gesellschaft Mit Beschrankter Haftung Porous bone replacement materials
US6007580A (en) * 1995-06-13 1999-12-28 Bionx Implants Oy Joint prosthesis
US6514286B1 (en) * 1996-12-03 2003-02-04 Osteobiologics, Inc. Biodegradable polymeric film
US6508838B2 (en) * 1997-04-22 2003-01-21 Washington Research Foundation Compositions for medical implantation
US5980573A (en) * 1997-05-12 1999-11-09 Shaffner; Richard L. Method and apparatus for fighting infection and maintaining joint spacing in a prosthesis implant area
US6113640A (en) * 1997-06-11 2000-09-05 Bionx Implants Oy Reconstructive bioabsorbable joint prosthesis
US6410044B1 (en) * 1998-03-19 2002-06-25 Surmodics, Inc. Crosslinkable macromers
US6210436B1 (en) * 1998-05-18 2001-04-03 Scimed Life Systems Inc. Implantable members for receiving therapeutically useful compositions
US6398814B1 (en) * 1998-09-14 2002-06-04 Bionx Implants Oy Bioabsorbable two-dimensional multi-layer composite device and a method of manufacturing same
US6419709B1 (en) * 1998-10-02 2002-07-16 Guilford Pharmaceuticals, Inc. Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same
US20030114936A1 (en) * 1998-10-12 2003-06-19 Therics, Inc. Complex three-dimensional composite scaffold resistant to delimination
US6454811B1 (en) * 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US6328765B1 (en) * 1998-12-03 2001-12-11 Gore Enterprise Holdings, Inc. Methods and articles for regenerating living tissue
US20010018614A1 (en) * 1999-03-16 2001-08-30 Bianchi John R. Implants for orthopedic applications
US6206927B1 (en) * 1999-04-02 2001-03-27 Barry M. Fell Surgically implantable knee prothesis
US20040267363A1 (en) * 1999-05-10 2004-12-30 Fell Barry M Surgically implantable knee prosthesis
US6719989B1 (en) * 1999-09-08 2004-04-13 Pentax Corporation Sustained release drug carrier, and method of manufacturing sustained release drug carrier
US20020013626A1 (en) * 2000-07-19 2002-01-31 Peter Geistlich Bone material and collagen combination for repair of injured joints
US20040030341A1 (en) * 2001-03-02 2004-02-12 Marcel Aeschlimann Implants, device and method for joining tissue parts
US20030033021A1 (en) * 2001-07-16 2003-02-13 Plouhar Pamela Lynn Cartilage repair and regeneration scaffold and method

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070222114A1 (en) * 2006-03-23 2007-09-27 Ziran Bruce H Method of forming a temporary implant and mold assembly for same
US7867426B2 (en) 2006-03-23 2011-01-11 Ziran Bruce H Method of forming a temporary implant
US20090069899A1 (en) * 2007-09-11 2009-03-12 Howmedica Osteonics Corp. Antibiotic bone cement spacer
US7842095B2 (en) 2007-09-11 2010-11-30 Howmedica Osteonics Corp. Antibiotic bone cement spacer
US20100297276A1 (en) * 2007-12-07 2010-11-25 Zimmer, Inc. Spacer Mold and Methods Therefor
US8480389B2 (en) 2007-12-07 2013-07-09 Zimmer Orthopedic Surgical Products, Inc. Spacer mold and methods therefor
US8801983B2 (en) 2007-12-07 2014-08-12 Zimmer Orthopaedic Surgical Products, Inc. Spacer mold and methods therefor
US20100102484A1 (en) * 2008-10-29 2010-04-29 Sean Haney Spacer molds with releasable securement
US8414286B2 (en) 2008-10-29 2013-04-09 Zimmer Orthopaedic Surgical Products, Inc. Spacer molds with releasable securement
US8899959B2 (en) 2008-10-29 2014-12-02 Zimmer Orthopaedic Surgical Products, Inc. Spacer molds with releasable securement
WO2013156743A1 (en) * 2012-04-19 2013-10-24 Teknimed Spacer implant for the temporary replacement of a knee prosthesis
FR2989568A1 (en) * 2012-04-19 2013-10-25 Teknimed Implant temporary replacement spacer of a knee prosthesis

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ITVI20000025U1 (en) 2001-10-08
AU4675201A (en) 2001-10-23

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