New! View global litigation for patent families

US20050085734A1 - Heart failure patient treatment and management device - Google Patents

Heart failure patient treatment and management device Download PDF

Info

Publication number
US20050085734A1
US20050085734A1 US10966487 US96648704A US2005085734A1 US 20050085734 A1 US20050085734 A1 US 20050085734A1 US 10966487 US10966487 US 10966487 US 96648704 A US96648704 A US 96648704A US 2005085734 A1 US2005085734 A1 US 2005085734A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
patient
weighted
parameters
baseline
device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10966487
Inventor
Amir Tehrani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RMX LLC
Original Assignee
Inspiration Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128Control systems
    • A61N1/36132Control systems using patient feedback
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/04Detecting, measuring or recording bioelectric signals of the body or parts thereof
    • A61B5/0488Electromyography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/08Detecting, measuring or recording devices for evaluating the respiratory organs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4806Sleep evaluation
    • A61B5/4818Sleep apnoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Detecting, measuring or recording for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/7264Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems

Abstract

A device and method to detect and manage heart failure patient symptoms is provided. Respiration and/or cardiac parameters may be sensed or observed to determine the status of a patient's condition. These symptoms may be classified for appropriate patient disease management. A patient's activity level may be monitored in conjunction with respiration and/or cardiac parameters to provide additional patient status information. These symptoms may be classified for appropriate patient disease management. Pulmonary edema is one condition that may be determined to exist when a respiration parameter is out of range for a given sensed activity level. If edema is determined to be present, the device may be configured to respond to treat the edema.

Description

    RELATED APPLICATION DATA
  • [0001]
    This application is a continuation-in-part of U.S. patent application Ser. No. 10/686,891, entitled: “BREATHING DISORDER DETECTION AND THERAPY DELIVERY DEVICE AND METHOD”, by Tehrani filed Oct. 15, 2003, and incorporated herein by reference.
  • FIELD OF THE INVENTION
  • [0002]
    The invention relates to devices and methods for managing heart failure patients by monitoring cardiac and/or respiration parameters and identifying the severity of heart failure/cardiac and/or pulmonary disorders. Another aspect includes monitoring pulmonary edema.
  • BACKGROUND OF THE INVENTION
  • [0003]
    A number of cardiac parameters are believed to be predictors of adverse outcomes in heart failure patients. Such parameters may relate, for example, to aspects of the ECG waveform and to heart rate.
  • [0004]
    Patients with heart failure are prone to a variety of cardiac arrhythmias that may have an important role in cardiac function, symptoms and prognosis.
  • [0005]
    General cardiac arrhythmias, including atrial fibrillation, ventricular tachycardia, and ventricular fibrillation have been monitored with pacemakers and defibrillators and are known to indicate improving or worsening of the patient's heart rhythms. The monitored information has been downloaded from these devices for such monitoring purposes.
  • [0006]
    However, such monitoring has not been used to provide comprehensive patient management.
  • [0007]
    Disordered breathing may contribute to a number of adverse cardiovascular outcomes such as hypertension, stroke, congestive heart failure, and myocardial infarction. Sleep-related breathing disorders, especially central sleep apnea, have been found to have a relatively high prevalence in patients with heart failure and may have a causative or influencing effect on heart failure. In about 50% of patients with stable congestive heart failure, there is an associated sleep disordered breathing, predominantly central sleep apnea, with a minority having obstructive sleep apnea. Furthermore, sleep related breathing disorders are believed to be physiologically linked with heart failure. Central sleep apnea is a known risk factor for diminished life expectancy in heart failure. It is also believed that in view of this link, treatment aimed at relieving sleep related breathing disorders may improve cardiovascular outcomes in patients with heart failure.
  • [0008]
    Pulmonary edema, a condition in which there is excess fluid in the lungs and often found in heart failure patients, is believed in some circumstances to lead to hyperventilation and hyperoxia or apnea. Most heart failure patients with central sleep apnea, when lying flat, tend to have central fluid accumulation and pulmonary congestion, which may stimulate vagal irritant receptors in the lungs to cause reflex hyperventilation. A severe form of pulmonary edema or fluid accumulation is known as decompensation.
  • [0009]
    While breathing disorders have been treated a number of ways, a comprehensive patient management with breathing disorder or pulmonary edema monitoring has not been provided.
  • [0010]
    Heart failure patients are prescribed on average 11 medications. Management of these patients has proven difficult particularly with the complexity of the various medications and patient lifestyle and drug compliance issues. Patient compliance tracking has been shown to decrease hospital rates and improve quality of life leading to reduced healthcare costs. However, this tracking system did not provide comprehensive patient monitoring.
  • SUMMARY OF THE INVENTION
  • [0011]
    The present invention provides a device and method for managing heart failure patients that utilizes cardiac and/or respiration monitoring. In addition to monitoring cardiac or respiration parameters, a patient's activity level may be monitored to further discern a level of patient condition severity. One aspect includes monitoring cardiac and/or respiratory conditions or states to detect decompensation. Another aspect includes monitoring cardiac and/or respiratory condition/states to predict, sense or detect decompensation. Decompensation typically requires urgent emergency care. Decompensation typically occurs when cardiac filling pressure increases, lungs fill with fluids, and cardiac output cannot meet the body's needs at rest. Another aspect includes sensing edema.
  • [0012]
    According to one aspect of the invention, one or more cardiac parameters may be monitored. The cardiac parameters may be monitored with an implanted device and its related electrodes from a location outside of the heart. In one particular example, an ECG may be sensed using electrodes positioned on the diaphragm. The electrodes may be positioned on a surface of the diaphragm such as the abdominal side. The thoracic side may be used as well. The phrenic nerve at or adjacent the diaphragm may also be used to sense ECG.
  • [0013]
    Additionally or alternatively one or more respiration parameters are monitored.
  • [0014]
    The observed parameter or parameters are used to determine a level of condition severity. In one particular variation, the shift from a baseline or normal parameter or parameters is used to determine the severity of the patient's condition. Based on that level, a course of action is provided for a patient.
  • [0015]
    One aspect of the invention provides for decompensation monitoring. As decompensation is developing, the ECG QRS and QT periods increase. The respiratory parameters also change as breathing becomes more rapid and shallow as compared to a baseline. Also, in some situations, pulmonary edema severity may increase.
  • [0016]
    One aspect of the invention provides for pulmonary edema monitoring, an indicator of heart failure status. According to this aspect of the invention, a pulmonary monitoring device senses a patient activity level and at least one respiration parameter. For example, a low or at rest activity level with a high or out of range respiration rate may indicate existence or a worsening of pulmonary edema. Other respiration parameters relative to a patient's activity level may indicate a worsening pulmonary edema condition. If a patient's respiratory rate increases with an increase in activity and decreases with a decrease in activity, within a normal range, the patient's system will be considered functioning normally. This information may be used in a patient management scheme that also monitors drug titrations, diuretic use, ACE Inhibitors, Beta Blockers and patient compliance.
  • [0017]
    Based on the observed parameters and/or compliance information a course of action may be provided or suggested. A provider may use the information in developing an optimum treatment plan for the patient including medication management, e.g. of drug titrations, diuretics, ACE inhibitors, and beta blockers. The system may also provide alarms and patient or provider communications if patient is in need of urgent attention possibly leading to hospitalization. This is a frequent occurrence with heart failure patients in decompensation. The patient compliance information may also be used for understanding the drug regimen effectiveness or dosing, whether the patient complies, or it may be used to educate the patient when there is lack of compliance with the therapy plan. If the patient's symptoms are brought more towards a normal range with a drug dose, then the drug treatment would be maintained. If the drug treatment did not affect the patient's symptoms sufficiently then the drug dosage may be increased. Accordingly, the drug dosage may vary with detected cardiac and/or breathing irregularities.
  • [0018]
    According to an aspect of the invention, the patient monitoring system provides continuous monitoring of physiological parameters to detect baseline shifts in cardiac and respiratory functions. This monitoring assists in supporting the patient with lifestyle and medication compliance. It further allows tiered intervention by providing daily patient self-management feedback, intervention according to programmed parameters by the physician (e.g., by increasing or decreasing medication), providing alerts to make office visits (including office visit scheduling), and providing urgent alerts for emergency room visits.
  • DESCRIPTION OF THE DRAWINGS
  • [0019]
    FIG. 1 illustrates a heart failure management system in accordance with the invention.
  • [0020]
    FIG. 2 is a flow chart illustrating a severity classification scheme for an awake patient with a low activity level.
  • [0021]
    FIG. 3 is a flow chart illustrating a severity classification scheme for an awake patient with a medium activity level.
  • [0022]
    FIG. 4 is a flow chart illustrating a severity classification scheme for an awake patient with a high activity level.
  • [0023]
    FIG. 5 is a flow chart illustrating a severity classification scheme for a sleeping patient.
  • [0024]
    FIG. 6 is a flow chart illustrating the operation of a heart failure management device in accordance with the invention.
  • [0025]
    FIG. 7 is a chart illustrating an averaging method according to a patient disorder classification scheme in accordance with the invention.
  • [0026]
    FIG. 8 is a schematic of an external controller that may be used for communications, data transfer and device programming.
  • DETAILED DESCRIPTION
  • [0027]
    Referring to FIG. 1, a heart failure management system 10 in accordance with the invention is illustrated. The system includes a sensor assembly 20, which in this particular illustration is coupled to a diaphragm 15 of a subject. More specifically the sensor assembly is located on the abdominal side of the diaphragm. However, one or more sensors that sense cardiac parameters or respiration parameters as may be used according to the invention, and may be positioned elsewhere in, on or adjacent a subject, including without limitation, on the thoracic side of the diaphragm or on the phrenic nerve at or adjacent the diaphragm.
  • [0028]
    The sensor assembly 20 comprises an electrode sensor 21 configured to sense signals from the phrenic nerve and/or diaphragm muscle. The signals may comprise a diaphragm EMG, phrenic nerve signals corresponding to respiration and/or an ECG signal. The sensor assembly 20 also includes a motion sensor 22 such as, e.g., an accelerometer. The motion sensor 22 may sense movement of the diaphragm 15 corresponding to respiration and/or other movement such as gross movements corresponding to subject activity.
  • [0029]
    The sensor assembly 20 is in communication with a controller 30 that includes signal processing circuits for processing signals from the sensors 21, 22 of the sensor assemble. The controller 30 also includes RAM memory and ROM memory. The memory devices contain programming information for controlling the device and processing signal information. The memory devices also include recording/data storage for recording data sensed by the sensors. The controller also includes an input/output device for communicating with the sensors and other devices such as external communication and controlling devices. The controller may also receive programming information from an external device.
  • [0030]
    In general, cardiac parameters that are sensed may indicate a condition of a heart failure patient. Such parameters may include ECG parameters, for example, QRS duration (typically duration of QRS complex in the frontal plane), QT interval (typically measured from the beginning of QRS to the end of T wave in the frontal plane), PR interval (typically measured from the beginning of P to the beginning of QRS in the frontal plane). As the heart failure worsens, the width of the QRS interval increases. Variations in QRS width could also be an indicator of a condition status. Similarly, QT dispersion may indicate an increase in heart failure. PR may indicate atrial conduction disturbances.
  • [0031]
    Incidences of atrial fibrillation, ventricular arrhythmia, and bradycardia may be detected, recorded or counted by sensing an ECG. Increase in these events may indicate a worsening of the heart failure patient's condition.
  • [0032]
    Heart rate and/or heart rate variability are cardiac parameters that may be sensed to indicate a condition status of a heart failure patient. Heart rate variability (HRV) for example, is a marker for autonomic tone and a risk predictor of part infarction mortality. Heart failure patients with worsening symptoms often have a decrease in their HRV.
  • [0033]
    In general respiratory parameters that are sensed may indicate a worsening of a heart failure patient's condition. Such worsening may include, but is not limited to, a worsening of pulmonary edema or decompensation.
  • [0034]
    Some of the respiratory parameters to monitor in awake patients in accordance with activity may include but are not limited to: respiratory rate and depth (may be categorized, e.g., as normal, rapid and shallow, rapid and deep; respiratory rate and depth correlation to minute ventilation; hyperventilation; incidence of periodic breathing and duration of periodic breathing; incidence of Cheyne-Stokes breathing; and the duration of the Cheyne Stoke hyperventilation and apnea portions.
  • [0035]
    High left-sided filling pressures and pulmonary congestion can cause rapid shallow breathing indicating a worsened condition. Rapid and deep respiration may indicate low SaO2 where a patient is compensating. Incidence of periodic breathing and duration of periodic breathing may indicate breathing patterns associated with a heart failure condition. Periodic breathing and Cheyne-Stokes breathing have higher rates of ventricular tachycardia than chronic heart failure patients without breathing disorders.
  • [0036]
    Some of the respiratory parameters to monitor during sleep may include but are not limited to: periodic breathing episodes; apnea episodes or Cheyne-Stokes episodes; information for calculation the AHI (Apnea Hyponea Index, a standardized sleep disorder measurement), Cheyne-Stokes patterns, number of events per period of time, episode durations, and peak diaphragm EMG/tidal volume. Average and standard deviation, averages and standard deviations of these parameters may also be measured or calculated as well.
  • [0037]
    Information that may be sensed for sensing decompensation may include any parameters that indicate an increased cardiac filling pressure and a cardiac output unable to meet the demands of the patient's physiology at rest. Such information may include, for example, an increased QRS or QT length as well as increased breathing rate, typically with shorten breathing amplitudes. These parameters may be compared to measured or otherwise set baseline parameters.
  • [0038]
    The information that may be sensed for pulmonary edema management (e.g., of hyperventilation rate and frequency of occurrence) may include the detections rate, detection amplitude, ventilation waveform morphology including slopes and surface of inspiration waveform, slopes and surface area of exhalation waveform, recorded respiratory waveform information in conjunction with activity and position sensor information.
  • [0039]
    The respiration information used may include all or part of a respiration waveform (e.g., length of cycle or a portion of the cycle, cycle frequency, amplitude, slope of the waveform or a portion of the waveform, waveform morphology), flow, tidal volume, peak tidal volume, averages and standard deviations breathing rate, etc. These parameters may be sensed using one or more respiration sensors, such as, e.g., EMG sensors, diaphragm, chest or other movement sensors, airway flow meters (pneumotachometer), and pressure sensors at one or more of various locations.
  • [0040]
    The sensors may also be coupled to a processor that may recognize certain breathing patterns such as periodic breathing, Cheyne-Stokes breathing patterns. These and other types of breathing patterns may be used as precursors to other breathing disorders such as described in U.S. patent application Ser. No. ______ entitled “Breathing Disorder and Precursor Predictor and Therapy Delivery Device and Method” filed on even date herewith and incorporated in its entirety herein. The processor may compare sensed breathing patterns to baseline breathing patterns and may determine what degree of correlation there is to the baseline breathing pattern. The baseline may be a normal breathing pattern where a strong correlation indicates normal breathing and a weak correlation indicates a likely breathing disorder. The baseline may be a disordered breathing pattern where a strong correlation indicates a likely breathing disorder. The sensor or processor may identify a general rate of hyperventilation or may count the number of identified episodes, e.g., in a particular time period.
  • [0041]
    The episodes may be correlated with an activity sensor and/or a real time clock that indicates whether the episodes are awake episodes or sleeping episodes and the level of activity of the patient, e.g., as high, medium or low, no activity.
  • [0042]
    The movement sensor 22 may sense acceleration and/or movement of the patient, and provide a corresponding signal to the controller 30. The sensor 22 measures the activity levels of the patient and provides the signal to the controller for use in further analysis. The movement signal from the sensor is processed to provide the information indicating the activity level of the patient in conjunction with cardiac and/or respiration parameters. The sensor senses activity threshold as no activity, low, medium or high depending on the programmed threshold value. Such value may be programmed or determined for a specific patient. Using the activity sensor value and cardiac or respiratory information, the health of the cardiac and/or respiratory system may be evaluated and monitored, for example as described with reference to FIGS. 2-7.
  • [0043]
    FIG. 6 is a flow chart illustrating a patient management device and method in accordance with the invention. At step 100 the patient state is determined in real time. This may be done using an activity sensor to determine the patient's activity level. The activity sensor may indicate sleep, low activity level, medium activity level or high activity level. The invention is not limited to these activity levels. Other gradations of activity levels may be used as well.
  • [0044]
    At step 101 which occurs in conjunction with step 110, cardiac and/or respiration parameters are determined, i.e., either sensed or determined from sensed information. The determined parameters and activity level as are stored for a period of time, for example for a 24 hour period. The parameters used may be selected from patient to patient. The baseline information used for comparison may be preset, programmed by a provider, and/or determined on a patient by patient basis by recording non-disordered patient parameters.
  • [0045]
    The cardiac parameters may include but are not limited to the ECG deviation from a baseline for a particular activity level, QRS duration deviation for a particular activity level, atrial fibrillation incidence, ventricular tachycardia incidence, ventricular fibrillation incidence, bradycardia incidence, and QT interval deviation from baseline.
  • [0046]
    The respiration parameters for an awake state may include, but are not limited to periodic breathing as a percentage of the total breathing during the particular state and rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing during the particular state.
  • [0047]
    The respiration parameters for a sleeping state may include but are not limited to Cheyne-Stokes duration, Cheyne-Stokes maximum amplitudes, AHI (apnea-hypopnea index) frequency of breathing, and frequency of occurrence of non-apnea hyperventilation during the particular state.
  • [0048]
    At steps 102 a-102 d, overall condition classifications for the patient at each of the defined activity levels is determined.
  • [0049]
    At step 102 a illustrated in more detail in FIG. 2, an overall condition classification of the patient in an awake state at a low activity level is determined.
  • [0050]
    At substep 120 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 120: the ECG deviation from a baseline is weighted by factor A1; QRS duration deviation is weighted by a factor B1; atrial fibrillation incidence is weighted by a factor C1; ventricular tachycardia incidence is weighted by a factor D1; ventricular fibrillation incidence is weighted by a factor E1; bradycardia incidence is weighted by a factor F1; and QT interval deviation from baseline is weighted by a factor G1. The weighted factors are these summed.
  • [0051]
    At substep 121 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 121: periodic breathing as a percentage of the total breathing is weighted by a factor of H1 and the rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing is weighted by a factor of I1.
  • [0052]
    At substep 122 following step 120 the summed weighted parameters A1-G1 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention.
  • [0053]
    Similarly at substep 123 following step 121 the summed weighted parameters H1-I1 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation.
  • [0054]
    At substep 124 following step 122 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification at substep 125 following step 123.
  • [0055]
    At substep 126, the overall classification is finally determined for step 102 a by combining the weighted cardiac classification with the weighted respiration classification.
  • [0056]
    At step 102 b illustrated in more detail in FIG. 5, an overall condition classification of the patient in an awake state at patient sleep state is determined.
  • [0057]
    At substep 150 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 150: the ECG deviation from a baseline is weighted by factor A2; QRS duration deviation is weighted by a factor B2; atrial fibrillation incidence is weighted by a factor C2; ventricular tachycardia incidence is weighted by a factor D2; ventricular fibrillation incidence is weighted by a factor E2; bradycardia incidence is weighted by a factor F2; and QT interval deviation from baseline is weighted by a factor G2. The weighted factors are then summed.
  • [0058]
    At substep 151 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 151: Cheyne-Stokes duration average during the observation period of time is weighted by a factor of J; the average of the maximum Cheyne-Stokes amplitude per occurrence during the time period is weighted by a factor of K; the AHI for the time period (the nighttime period) is weighted by a factor of L; and the frequency of occurrence of non apnea hyperventilation is weighted by a factor of M.
  • [0059]
    At substep 152 following step 120 the summed weighted parameters A2-G2 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention.
  • [0060]
    Similarly at substep 153 following step 151 the summed weighted parameters J-M are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation.
  • [0061]
    At substep 154 following step 152 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification at substep 155 following step 153.
  • [0062]
    At substep 156, the overall classification is finally determined for step 102 b by combining the weighted cardiac classification with the weighted respiration classification.
  • [0063]
    At step 102 c illustrated in more detail in FIG. 3, an overall condition classification of the patient in an awake state at a medium activity level is determined.
  • [0064]
    At substep 130 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 130: the ECG deviation from a baseline is weighted by factor A3; QRS duration deviation is weighted by a factor B3; atrial fibrillation incidence is weighted by a factor C3; ventricular tachycardia incidence is weighted by a factor D3; ventricular fibrillation incidence is weighted by a factor E3; bradycardia incidence is weighted by a factor F3; and QT interval deviation from baseline is weighted by a factor G3. The weighted factors are then summed.
  • [0065]
    At substep 131 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 131: periodic breathing as a percentage of the total breathing is weighted by a factor of H3 and the rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing is weighted by a factor of I3.
  • [0066]
    At substep 132 following step 130 the summed weighted parameters A3-G3 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention.
  • [0067]
    Similarly at substep 133 following step 131 the summed weighted parameters H3-I3 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation.
  • [0068]
    At substep 134 following step 132 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification at substep 135 following step 133.
  • [0069]
    At substep 136, the overall classification is finally determined for step 102 c by combining the weighted cardiac classification with the weighted respiration classification.
  • [0070]
    At step 102 d illustrated in more detail in FIG. 4, an overall condition classification of the patient in an awake state at a high activity level is determined.
  • [0071]
    At substep 140 each of the cardiac parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 140: the ECG deviation from a baseline is weighted by factor 41; QRS duration deviation is weighted by a factor B4; atrial fibrillation incidence is weighted by a factor C4; ventricular tachycardia incidence is weighted by a factor D4; ventricular fibrillation incidence is weighted by a factor E4; bradycardia incidence is weighted by a factor F4; and QT interval deviation from baseline is weighted by a factor G4. The weighted factors are then summed.
  • [0072]
    At substep 141 each of the respiration parameters measured and recorded over the period of time of recording are weighted. Each of the parameters are weighted differently. These weight factors may be preprogrammed into the device. The weight factors may also be programmed in on a patient by patient basis by a provider and are adjustable. As shown in step 141: periodic breathing as a percentage of the total breathing is weighted by a factor of H4 and the rate of Cheyne-Stokes respiration or hyperventilation as a percentage of the total breathing is weighted by a factor of I4.
  • [0073]
    At substep 142 following step 140 the summed weighted parameters A4-G4 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A cardiac classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation. These baseline shifts are exemplary and are not intended to limit the classification scheme according to the invention.
  • [0074]
    Similarly at substep 143 following step 141 the summed weighted parameters H4-I4 are compared to a baseline for the summed parameters. This baseline also may be preset or programmed into the device on a patient by patient basis. This baseline is also adjustable by a provider. A respiration classification is then determined as follows: a 10% or less base line shift is classified as normal; a baseline shift between 10% and 20% is classified as a mild deviation; a baseline shift from 20% to 30% is classified as a medium deviation; and above a 30% baseline shift is classified as a severe deviation.
  • [0075]
    At substep 144 following step 142 the cardiac classification is weighted as a percentage of the total overall classification with the respiration classification being weighted as the remainder percentage of the total overall classification at substep 145 following step 143.
  • [0076]
    At substep 146, the overall classification is finally determined for step 102 d by combining the weighted cardiac classification with the weighted respiration classification.
  • [0077]
    Referring again to FIG. 6, after overall Awake low classification has been determined in step 102 a and the overall sleep classification has been determined in step 102 b, if either of these classifications is severe 103 then in step 104, the physician is informed for an office visit and/or ER admission is prepared through communication with the physician and/or hospital using a communication device such as described with respect to FIG. 8.
  • [0078]
    Otherwise in step 105, an average of the overall classifications values for the four conditions determined in steps 1-4 is calculated in accordance with the chart illustrated in FIG. 7. As shown in FIG. 7, a number 0, 1, 2, or 3 is assigned for each overall classification for a given condition.
  • [0079]
    If the average is less than 1, the average is considered normal 106 and no further course of action is suggested. If the average is greater than or equal to 1 and less than 2, the average is considered mild 108 and a suggestion is made for lifestyle change and compliance with medicine 109. Such lifestyle change may also include a suggestion for exercise. This communication may be made via a patient self management module or communication device as described with reference to FIG. 8. If the average is greater than or equal to 2 and less than 2.5 the average is considered medium 110. The patient self management module as described in FIG. 8 accordingly provides instructions to change medication according to a physician programmed value and an office visit is scheduled 111. Alternatively, a physician may be notified and the medication dosage changed by a physician before or after an office visit. If the average is greater than or equal to 2.5, then the average is considered severe 112. Then in step 113, the physician is informed for an office visit and/or ER admission is prepared through communication with the physician and/or hospital using a communication device such as described with respect to FIG. 8.
  • [0080]
    FIG. 8 is a schematic of an external controller device 40 that may be used for communications, data transfer and device programming. The external device 140 comprises a processor 45 for controlling the operations of the external device. The processor 45 and other electrical components of the external device 40 are coordinated by an internal clock 50 and a power source 51. The processor 45 is coupled to a telemetry circuit 46 that includes a telemetry coil 47, a receiver circuit 48 for receiving and processing a telemetry signal that is converted to a digital signal and communicated to the processor 45, and a transmitter circuit 49 for processing and delivering a signal from the processor 45 to the telemetry coil 46. The telemetry coil 47 is an RF coil or alternatively may be a magnetic coil depending on what type of coil a telemetry coil of the implanted controller 30 may be.
  • [0081]
    The telemetry circuit 46 is configured to transmit to the implanted controller 30, signals containing, e.g., programming or other instructions or information, programmed stimulation rates and pulse widths, electrode configurations, and other device performance details.
  • [0082]
    The telemetry circuit 46 is also configured to receive telemetry signals from the implanted controller 30 that may contain, e.g., sensed and/or accumulated data such as the sensed information corresponding to the cardiac and respiration parameters described herein. Such sensed data may include sensed ECG, heart rate data, sensed EMG activity, sensed nerve activity, sensed movement information whether corresponding to breathing or to patient activity. The information may contain raw or processed data or signals. The patient management system may be contained in part or in whole in the implanted sensor 30 or the external controller 40. Other information such as frequency and time of cardiac or respiratory events, number of cardiac or respiratory events detected in a time interval or during a sleep cycle may be included in the uploaded information as well as the correlated recorded activity level.
  • [0083]
    With respect to pulmonary edema monitoring, related parameters such as frequency of hyperventilation including time and patient activity level may be recorded and uploaded to the external device 40.
  • [0084]
    The uploaded information may be stored in RAM event memory 58 or may be uploaded and through an external port 53 to a computer, or processor, either directly or through a phone line or other communication device that may be coupled to the processor 45 through the external port 53. The external device 40 also includes ROM memory 57 for storing and providing operating instructions to the external device 40 and processor 45. The external device also includes RAM event memory 58 for storing uploaded event information such as sensed information and data from the control unit 30, and RAM program memory 59 for system operations and future upgrades. The external device also includes a buffer 54 coupled to or that can be coupled through a port to a user-operated device 55 such as a keypad input or other operation devices. Finally, the external device 40 includes a display device 56 (or a port where such device can be connected), e.g., for display visual, audible or tactile information, alarms or pages.
  • [0085]
    The external device 40 is configured to communicate patient disease status classifications to a handheld device, computer, or provider/hospital communications interface as described in steps 104, 107, 109, 111, 113. In addition to communicating the patient disease status classifications described in steps 104, 107, 109, 111, 113, the device may also manage a patient's diuretic or other medication level in relationship to breathing frequency and character. The device may monitor the response of the treatment from measured parameters provided by the control unit 100 in response to diuretic or other medication usage that e.g., may be input by the patient. The system could also direct the patient to rest in different positions to alleviate the present problem until help arrives.
  • [0086]
    The external device may be equipped with a palm pilot type device that connects to the phone line for downloading the patient specific information regarding patient's cardiac, respiratory or pulmonary edema status, and whether the parameters are programmed correctly. This device may allow for remote follow-up, continuous monitoring of the patient's status, effectiveness of the drug regime for a heart failure patient. The device may provide for management of medications (including, e.g., diuretics ACE inhibitors, or beta blockers) for such heart failure related conditions such as pulmonary edema. The information may be viewed by the clinician using a web browser anywhere in the world of the handheld can send a fax or notice to the physician's office once the parameters of interest are outside the programmed range. The physician may then request an office visit. The system also can send a summarized report on weekly, biweekly, or monthly as routine update based on the decision of the physician programmed in the handheld device. Medication adjustment/drug titration may be accomplished remotely. Hand-held communication protocol/technology may be magnetic or RF.
  • [0087]
    The patient management device may be used in conjunction or incorporated into various therapy devices such as, e.g., diaphragm stimulation devices as described, for example in U.S. application Ser. No. 10/686,891, entitled: “BREATHING DISORDER DETECTION AND THERAPY DELIVERY DEVICE AND METHOD”, by Tehrani filed Oct. 15, 2003, and incorporated herein by reference.
  • [0088]
    Safety mechanisms may be incorporated into any stimulation device in accordance with the invention. The safety feature disables the device under certain conditions. Such safety features may include a patient or provider operated switch, e.g. a magnetic switch. In addition a safety mechanism may be included that determines when patient intervention is being provided. For example, the device will turn off if there is diaphragm movement sensed without an EMG as the case would be where a ventilator is being used.
  • [0089]
    While the invention has been described in detail with reference to preferred embodiments thereof, it will be apparent to one skilled in the art that various changes can be made, and equivalents employed, without departing from the scope of the invention.

Claims (46)

  1. 1. A patient management system comprising:
    an implantable device comprising:
    a physiological sensor configured to be coupled to a patient to monitor the patient, and configured to sense at least one cardiac parameter and at least one respiration parameter;
    a patient condition status identifier configured to identify a patient condition status based on the at least one cardiac parameter and the at least one respiration parameter.
  2. 2. The system of claim 1 wherein the condition status corresponds to a patient's heart failure status.
  3. 3. The system of claim 1 wherein the patient status identifier further comprises a severity level sensor configured to determine a patient condition severity level.
  4. 4. The system of claim 3 further comprising a responsive element configured to recommend a patient action based on the condition severity level.
  5. 5. The system of claim 4 wherein the responsive element is configured to provide a medication intervention instruction based on the condition severity level.
  6. 6. The system of claim 4 wherein the responsive element is configured to recommend a lifestyle modification.
  7. 7. The system of claim 4 wherein the responsive element is configured to recommend a provider intervention.
  8. 8. The system of claim 4 wherein the responsive element is configured to recommend an emergency intervention.
  9. 9. The system of claim 1 further comprising a patient status communicator coupled to the patient status identifier and configured to communicate a patient status to a user.
  10. 10. The system of claim 9 wherein the user is a patient.
  11. 11. The system of claim 9 wherein the user is a health care provider.
  12. 12. The system of claim 1 further comprising an activity monitor configured to detect patient activity.
  13. 13. The system of claim 12 wherein the physiological sensor is further configured to correlate an activity level sensed by the activity monitor with one or more of the at least one cardiac parameter and the at least one respiration parameter.
  14. 14. The system of claim 13 wherein the correlated activity with the at least one parameter further qualifies the patient status.
  15. 15. The system of claim 1 wherein the patient status identifier comprises a baseline comparator configured to compare a baseline to the at least one parameter.
  16. 16. The system of claim 15 wherein the patient status identifier is configured to identify a patient condition severity level at least in part based on the comparison of the baseline to the at least one parameter.
  17. 17. The system of claim 1 wherein the device further comprises a patient compliance monitor.
  18. 18. The system of claim 1 wherein the physiological parameter sensor is configured to sense a plurality of parameters and wherein the patient status identifier is configured to identify the patient condition status based the plurality of parameters
  19. 19. The system of claim 1, wherein the physiological parameter sensor is configured to sense the cardiac parameter from a location external to a patient's heart.
  20. 20. The system of claim 1 wherein the physiological parameter sensor is configured to continuously monitor at least one parameter.
  21. 21. The system of claim 1 wherein the patient condition status identifier is configured to identify a patient decompensating status.
  22. 22. A method of managing a patient comprising the steps of:
    continuously monitoring at least one cardiac parameter and at least one respiration parameter;
    sensing the at least one cardiac parameter and at least one respiration parameter; and
    identifying a patient status based on the at least one cardiac parameter and at least one respiration parameter.
  23. 23. The method of claim 22 further comprising the step of determining a patient condition severity level based on the at least one cardiac parameter and at least one respiration parameter.
  24. 24. The method of claim 23 further comprising the step of recommending a patient course of action based on the patient condition severity level.
  25. 25. The method of claim 23 further comprising the step of communicating the patient condition severity level to the patient.
  26. 26. The method of claim 23 further comprising the step of communicating the patient condition severity level to a healthcare provider.
  27. 27. A device for detecting pulmonary edema comprising
    a first sensor configured to sense activity of a subject and to generate a first signal corresponding to the activity of a subject;
    a second sensor configured to sense at least one respiration parameter of the subject and generate a second signal corresponding to the at least on respiration parameter; and
    an edema analyzer coupled to the first sensor and the second sensor, the edema analyzer configured to sense edema based on the first signal and the second signal.
  28. 28. The device of claim 27 wherein the first sensor is configured to sense motion of a subject.
  29. 29. The device of claim 27 wherein the at least one respiration parameter comprises a respiration rate.
  30. 30. The device of claim 27 wherein the at least one respiration parameter comprises a morphology of a respiration waveform.
  31. 31. The device of claim 27 wherein the edema detector is configured to detect edema when a sensed respiration rate exceeds a predetermined level of a sensed activity level.
  32. 32. A method for detecting pulmonary edema comprising the steps of:
    sensing activity of a subject;
    sensing at least one respiration parameter of the subject; and
    determining a pulmonary edema condition based on the activity and respiration parameter of the subject.
  33. 33. The method of claim 32 wherein the step of determining pulmonary edema condition comprises determining a relative severity level of the pulmonary edema condition.
  34. 34. A patient management system comprising:
    an implantable device comprising:
    a physiological sensor configured to be coupled to a patient to continuously monitor the patient, and configured to sense at least one physiological parameter selected from: at least one cardiac parameter sensed from a location external the heart and at least one respiration parameter;
    a patient condition status identifier configured to identify a patient condition status based on the at least one physiological parameter.
  35. 35. The system of claim 34 wherein the condition status corresponds to a patient's heart failure status.
  36. 36. The system of claim 34 wherein the patient status identifier further comprises a severity level sensor configured to determine a patient condition severity level.
  37. 37. The system of claim 36 further comprising a responsive element configured to recommend a patient action based on the condition severity level.
  38. 38. The system of claim 37 wherein the responsive element is configured to provide a medication intervention instruction based on the condition severity level.
  39. 39. The system of claim 37 wherein the responsive element is configured to recommend a lifestyle modification.
  40. 40. The system of claim 37 wherein the responsive element is configured to recommend a provider intervention.
  41. 41. The system of claim 37 wherein the responsive element is configured to recommend an emergency intervention.
  42. 42. A device for sensing cardiac parameters comprising:
    at least one electrode configured to be positioned adjacent a diaphragm of a subject and configured to sense an ECG signal.
  43. 43. The device of claim 43 wherein the at least one electrode is configured to be positioned on the abdominal surface of a diaphragm.
  44. 44. A method for sensing cardiac parameters comprising:
    positioning an electrode adjacent a diaphragm of a subject; and
    sensing an ECG with the diaphragm.
  45. 45. The method of claim 44 wherein the step of positioning the electrode adjacent the diaphragm comprises positioning the electrode at the abdominal side of the diaphragm.
  46. 46. The method of claim 44 wherein the step of positioning the electrode adjacent the diaphragm comprises positioning the electrode at the thoracic side of the diaphragm.
US10966487 2003-10-15 2004-10-15 Heart failure patient treatment and management device Abandoned US20050085734A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10686891 US8467876B2 (en) 2003-10-15 2003-10-15 Breathing disorder detection and therapy delivery device and method
US10966487 US20050085734A1 (en) 2003-10-15 2004-10-15 Heart failure patient treatment and management device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10966487 US20050085734A1 (en) 2003-10-15 2004-10-15 Heart failure patient treatment and management device
US13598284 US20120323293A1 (en) 2003-10-15 2012-08-29 Device and method for treating disorders of the cardiovascular system or heart

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11480074 Continuation-In-Part US8160711B2 (en) 2003-10-15 2006-06-29 Multimode device and method for controlling breathing

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11271264 Continuation-In-Part US7979128B2 (en) 2003-10-15 2005-11-10 Device and method for gradually controlling breathing

Publications (1)

Publication Number Publication Date
US20050085734A1 true true US20050085734A1 (en) 2005-04-21

Family

ID=34465515

Family Applications (15)

Application Number Title Priority Date Filing Date
US10686891 Active 2026-09-30 US8467876B2 (en) 2003-10-15 2003-10-15 Breathing disorder detection and therapy delivery device and method
US10966474 Active 2025-11-29 US8412331B2 (en) 2003-10-15 2004-10-15 Breathing therapy device and method
US10966484 Abandoned US20050085869A1 (en) 2003-10-15 2004-10-15 System and method for mapping diaphragm electrode sites
US10966421 Active 2026-02-19 US8255056B2 (en) 2003-10-15 2004-10-15 Breathing disorder and precursor predictor and therapy delivery device and method
US10966487 Abandoned US20050085734A1 (en) 2003-10-15 2004-10-15 Heart failure patient treatment and management device
US10966472 Active 2026-12-07 US8200336B2 (en) 2003-10-15 2004-10-15 System and method for diaphragm stimulation
US11246439 Abandoned US20060030894A1 (en) 2003-10-15 2005-10-11 Breathing disorder detection and therapy device for providing intrinsic breathing
US11249718 Active 2024-09-20 US8348941B2 (en) 2003-10-15 2005-10-13 Demand-based system for treating breathing disorders
US11526949 Expired - Fee Related US8509901B2 (en) 2003-10-15 2006-09-25 Device and method for adding to breathing
US11981800 Active 2024-12-08 US8116872B2 (en) 2003-10-15 2007-10-31 Device and method for biasing and stimulating respiration
US11981831 Abandoned US20080183240A1 (en) 2003-10-15 2007-10-31 Device and method for manipulating minute ventilation
US11981727 Abandoned US20080183239A1 (en) 2003-10-15 2007-10-31 Breathing therapy device and method
US12080133 Abandoned US20080188903A1 (en) 2003-10-15 2008-04-01 Device and method for biasing and stimulating respiration
US13851003 Abandoned US20130296973A1 (en) 2003-10-15 2013-03-26 Breathing therapy device and method
US13915316 Abandoned US20130296964A1 (en) 2003-10-15 2013-06-11 Breathing disorder detection and therapy delivery device and method

Family Applications Before (4)

Application Number Title Priority Date Filing Date
US10686891 Active 2026-09-30 US8467876B2 (en) 2003-10-15 2003-10-15 Breathing disorder detection and therapy delivery device and method
US10966474 Active 2025-11-29 US8412331B2 (en) 2003-10-15 2004-10-15 Breathing therapy device and method
US10966484 Abandoned US20050085869A1 (en) 2003-10-15 2004-10-15 System and method for mapping diaphragm electrode sites
US10966421 Active 2026-02-19 US8255056B2 (en) 2003-10-15 2004-10-15 Breathing disorder and precursor predictor and therapy delivery device and method

Family Applications After (10)

Application Number Title Priority Date Filing Date
US10966472 Active 2026-12-07 US8200336B2 (en) 2003-10-15 2004-10-15 System and method for diaphragm stimulation
US11246439 Abandoned US20060030894A1 (en) 2003-10-15 2005-10-11 Breathing disorder detection and therapy device for providing intrinsic breathing
US11249718 Active 2024-09-20 US8348941B2 (en) 2003-10-15 2005-10-13 Demand-based system for treating breathing disorders
US11526949 Expired - Fee Related US8509901B2 (en) 2003-10-15 2006-09-25 Device and method for adding to breathing
US11981800 Active 2024-12-08 US8116872B2 (en) 2003-10-15 2007-10-31 Device and method for biasing and stimulating respiration
US11981831 Abandoned US20080183240A1 (en) 2003-10-15 2007-10-31 Device and method for manipulating minute ventilation
US11981727 Abandoned US20080183239A1 (en) 2003-10-15 2007-10-31 Breathing therapy device and method
US12080133 Abandoned US20080188903A1 (en) 2003-10-15 2008-04-01 Device and method for biasing and stimulating respiration
US13851003 Abandoned US20130296973A1 (en) 2003-10-15 2013-03-26 Breathing therapy device and method
US13915316 Abandoned US20130296964A1 (en) 2003-10-15 2013-06-11 Breathing disorder detection and therapy delivery device and method

Country Status (3)

Country Link
US (15) US8467876B2 (en)
DE (3) DE112004001953T5 (en)
WO (6) WO2005037172A3 (en)

Cited By (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050085867A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. System and method for diaphragm stimulation
US20060101871A1 (en) * 2004-11-12 2006-05-18 Matsushita Electric Industrial Co., Ltd. Drum type washing and drying machine
US20060122662A1 (en) * 2003-10-15 2006-06-08 Tehrani Amir J Device and method for increasing functional residual capacity
US20060149334A1 (en) * 2003-10-15 2006-07-06 Tehrani Amir J Device and method for controlling breathing
US20060155341A1 (en) * 2003-10-15 2006-07-13 Tehrani Amir J Device and method for biasing lung volume
US20060241512A1 (en) * 2005-04-20 2006-10-26 Cardiac Pacemakers, Inc. Thoracic or intracardiac impedance detection with automatic vector selection
US20060247729A1 (en) * 2003-10-15 2006-11-02 Tehrani Amir J Multimode device and method for controlling breathing
US20070021678A1 (en) * 2005-07-19 2007-01-25 Cardiac Pacemakers, Inc. Methods and apparatus for monitoring physiological responses to steady state activity
US20070043394A1 (en) * 2005-08-22 2007-02-22 Cardiac Pacemakers, Inc Intracardiac impedance and its applications
US20070044669A1 (en) * 2005-08-24 2007-03-01 Geise Gregory D Aluminum can compacting mechanism with improved actuation handle assembly
US20070049793A1 (en) * 2005-08-25 2007-03-01 Ignagni Anthony R Method And Apparatus For Transgastric Neurostimulation
US20070066905A1 (en) * 2005-09-21 2007-03-22 Cardiac Pacemakers, Inc. Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance
US7206635B2 (en) * 2001-06-07 2007-04-17 Medtronic, Inc. Method and apparatus for modifying delivery of a therapy in response to onset of sleep
US20070118054A1 (en) * 2005-11-01 2007-05-24 Earlysense Ltd. Methods and systems for monitoring patients for clinical episodes
US20070118183A1 (en) * 2005-11-18 2007-05-24 Mark Gelfand System and method to modulate phrenic nerve to prevent sleep apnea
US20070150023A1 (en) * 2005-12-02 2007-06-28 Ignagni Anthony R Transvisceral neurostimulation mapping device and method
US20070265611A1 (en) * 2004-07-23 2007-11-15 Ignagni Anthony R Ventilatory assist system and methods to improve respiratory function
US20080004668A1 (en) * 2004-08-09 2008-01-03 Cardiac Pacemakers, Inc. Cardiopulmonary functional status assessment via heart rate response dectection by implantable cardiac device
US20080109047A1 (en) * 2006-10-26 2008-05-08 Pless Benjamin D Apnea treatment device
US20080114410A1 (en) * 2005-05-25 2008-05-15 Cardiac Pacemakers, Inc. Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
US20080154330A1 (en) * 2006-12-22 2008-06-26 Tehrani Amir J Device and method to treat flow limitations
US20080167695A1 (en) * 2003-10-15 2008-07-10 Tehrani Amir J Therapeutic diaphragm stimulation device and method
US20080188904A1 (en) * 2003-10-15 2008-08-07 Tehrani Amir J Device and method for treating disorders of the cardiovascular system or heart
US20080188867A1 (en) * 2007-02-05 2008-08-07 Ignagni Anthony R Removable intramuscular electrode
US20080208282A1 (en) * 2007-01-22 2008-08-28 Mark Gelfand Device and method for the treatment of breathing disorders and cardiac disorders
US20080234556A1 (en) * 2007-03-20 2008-09-25 Cardiac Pacemakers, Inc. Method and apparatus for sensing respiratory activities using sensor in lymphatic system
US20080269625A1 (en) * 2004-02-05 2008-10-30 Earlysense Ltd. Prediction and monitoring of clinical episodes
US20080287820A1 (en) * 2007-05-17 2008-11-20 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US20090062882A1 (en) * 2007-08-28 2009-03-05 Cardiac Pacemakers, Inc. Method and apparatus for inspiratory muscle stimulation using implantable device
US20090099621A1 (en) * 2007-10-10 2009-04-16 Zheng Lin Respiratory stimulation for treating periodic breathing
US20090118785A1 (en) * 2007-10-30 2009-05-07 Ignagni Anthony R Method of improving sleep disordered breathing
US20090192394A1 (en) * 2008-01-16 2009-07-30 Guttag John V Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal
WO2009114548A1 (en) * 2008-03-12 2009-09-17 Corventis, Inc. Heart failure decompensation prediction based on cardiac rhythm
US20100016748A1 (en) * 2008-07-17 2010-01-21 Syed Zeeshan H Motif Discovery in Physiological Datasets: A Methodology for Inferring Predictive Elements
US20100076324A1 (en) * 2008-09-19 2010-03-25 Cho Yong K Method and apparatus for detecting respiratory effort in a medical device
US7704211B1 (en) * 2005-03-21 2010-04-27 Pacesetter, Inc. Method and apparatus for assessing fluid level in lungs
US20100160992A1 (en) * 2007-05-28 2010-06-24 St. Jude Medical Ab Implantable medical device, system and method
US20100228133A1 (en) * 2005-09-16 2010-09-09 Averina Viktoria A System and Method for Generating a Trend Parameter Based on Respiration Rate Distribution
US20110054279A1 (en) * 2008-03-27 2011-03-03 Widemed Ltd. Diagnosis of periodic breathing
US20110060381A1 (en) * 2003-07-23 2011-03-10 Ignagni Anthony R System and Method for Conditioning a Diaphragm of a Patient
US20110060380A1 (en) * 2009-09-10 2011-03-10 Mark Gelfand Respiratory rectification
US7917194B1 (en) * 2006-11-15 2011-03-29 Pacesetter, Inc. Method and apparatus for detecting pulmonary edema
US20110230932A1 (en) * 2003-10-15 2011-09-22 Rmx, Llc Device and method for independently stimulating hemidiaphragms
US8116841B2 (en) 2007-09-14 2012-02-14 Corventis, Inc. Adherent device with multiple physiological sensors
US20120157799A1 (en) * 2010-12-20 2012-06-21 Abhilash Patangay Using device based sensors to classify events and generate alerts
US8244358B2 (en) 2003-10-15 2012-08-14 Rmx, Llc Device and method for treating obstructive sleep apnea
US8249686B2 (en) 2007-09-14 2012-08-21 Corventis, Inc. Adherent device for sleep disordered breathing
US8374688B2 (en) 2007-09-14 2013-02-12 Corventis, Inc. System and methods for wireless body fluid monitoring
US8376954B2 (en) 2004-02-05 2013-02-19 Earlysense Ltd. Techniques for prediction and monitoring of respiration-manifested clinical episodes
US8412317B2 (en) 2008-04-18 2013-04-02 Corventis, Inc. Method and apparatus to measure bioelectric impedance of patient tissue
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US8433412B1 (en) 2008-02-07 2013-04-30 Respicardia, Inc. Muscle and nerve stimulation
US8460189B2 (en) 2007-09-14 2013-06-11 Corventis, Inc. Adherent cardiac monitor with advanced sensing capabilities
US8491492B2 (en) 2004-02-05 2013-07-23 Earlysense Ltd. Monitoring a condition of a subject
US20130197385A1 (en) * 2012-01-31 2013-08-01 Medtronic, Inc. Respiratory function detection
US8509902B2 (en) 2011-07-28 2013-08-13 Medtronic, Inc. Medical device to provide breathing therapy
US8538525B2 (en) 2004-08-12 2013-09-17 Cardiac Pacemakers, Inc. Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device
US8585607B2 (en) 2007-05-02 2013-11-19 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8585604B2 (en) 2010-10-29 2013-11-19 Medtronic, Inc. Integrated patient care
US20140031643A1 (en) * 2012-07-27 2014-01-30 Cardiac Pacemakers, Inc. Heart failure patients stratification
US8684925B2 (en) 2007-09-14 2014-04-01 Corventis, Inc. Injectable device for physiological monitoring
CN103800999A (en) * 2014-02-25 2014-05-21 郑州雅晨生物科技有限公司 Obstructive sleep apnea hypopnea syndrome therapeutic apparatus
US8790259B2 (en) 2009-10-22 2014-07-29 Corventis, Inc. Method and apparatus for remote detection and monitoring of functional chronotropic incompetence
US8821418B2 (en) 2007-05-02 2014-09-02 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8823490B2 (en) 2008-12-15 2014-09-02 Corventis, Inc. Patient monitoring systems and methods
US8882684B2 (en) 2008-05-12 2014-11-11 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8897868B2 (en) 2007-09-14 2014-11-25 Medtronic, Inc. Medical device automatic start-up upon contact to patient tissue
US8942779B2 (en) 2004-02-05 2015-01-27 Early Sense Ltd. Monitoring a condition of a subject
US8965498B2 (en) 2010-04-05 2015-02-24 Corventis, Inc. Method and apparatus for personalized physiologic parameters
US20150057555A1 (en) * 2013-08-20 2015-02-26 Sorin Crm Sas Systems and methods for diagnosing heart failure based on sleep apneic indicators
WO2016013684A1 (en) * 2014-07-22 2016-01-28 帝人ファーマ株式会社 Heart failure evaluation method and diagnosis device
US9295397B2 (en) 2013-06-14 2016-03-29 Massachusetts Institute Of Technology Method and apparatus for beat-space frequency domain prediction of cardiovascular death after acute coronary event
US9411936B2 (en) 2007-09-14 2016-08-09 Medtronic Monitoring, Inc. Dynamic pairing of patients to data collection gateways
US9451897B2 (en) 2009-12-14 2016-09-27 Medtronic Monitoring, Inc. Body adherent patch with electronics for physiologic monitoring
US20170112409A1 (en) * 2013-02-06 2017-04-27 BTS S.p.A. Wireless probe for dental electromyography
US9743889B2 (en) 2013-08-05 2017-08-29 Cardiac Pacemakers, Inc. System and method for detecting worsening of heart failure based on rapid shallow breathing index
US9839781B2 (en) 2005-08-22 2017-12-12 Cardiac Pacemakers, Inc. Intracardiac impedance and its applications
US9861817B2 (en) 2011-07-28 2018-01-09 Medtronic, Inc. Medical device to provide breathing therapy
US9883809B2 (en) 2008-05-01 2018-02-06 Earlysense Ltd. Monitoring, predicting and treating clinical episodes

Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060155206A1 (en) 1997-01-27 2006-07-13 Lynn Lawrence A System and method for sound and oximetry integration
US9042952B2 (en) 1997-01-27 2015-05-26 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US9521971B2 (en) 1997-07-14 2016-12-20 Lawrence A. Lynn System and method for automatic detection of a plurality of SPO2 time series pattern types
US9468378B2 (en) 1997-01-27 2016-10-18 Lawrence A. Lynn Airway instability detection system and method
US9053222B2 (en) 2002-05-17 2015-06-09 Lawrence A. Lynn Patient safety processor
US8932227B2 (en) 2000-07-28 2015-01-13 Lawrence A. Lynn System and method for CO2 and oximetry integration
US5915380A (en) 1997-03-14 1999-06-29 Nellcor Puritan Bennett Incorporated System and method for controlling the start up of a patient ventilator
US20060195041A1 (en) 2002-05-17 2006-08-31 Lynn Lawrence A Centralized hospital monitoring system for automatically detecting upper airway instability and for preventing and aborting adverse drug reactions
US20080077192A1 (en) * 2002-05-03 2008-03-27 Afferent Corporation System and method for neuro-stimulation
DE10248590B4 (en) 2002-10-17 2016-10-27 Resmed R&D Germany Gmbh A method and apparatus for performing signal processing of an observation with the respiratory activity of a person in connection measuring signal
US20050107838A1 (en) * 2003-09-18 2005-05-19 Lovett Eric G. Subcutaneous cardiac rhythm management with disordered breathing detection and treatment
US7477932B2 (en) * 2003-05-28 2009-01-13 Cardiac Pacemakers, Inc. Cardiac waveform template creation, maintenance and use
EP2008581B1 (en) 2003-08-18 2011-08-17 Cardiac Pacemakers, Inc. Patient monitoring, diagnosis, and/or therapy systems and methods
US7396333B2 (en) 2003-08-18 2008-07-08 Cardiac Pacemakers, Inc. Prediction of disordered breathing
US8002553B2 (en) 2003-08-18 2011-08-23 Cardiac Pacemakers, Inc. Sleep quality data collection and evaluation
US7662101B2 (en) * 2003-09-18 2010-02-16 Cardiac Pacemakers, Inc. Therapy control based on cardiopulmonary status
US7887493B2 (en) 2003-09-18 2011-02-15 Cardiac Pacemakers, Inc. Implantable device employing movement sensing for detecting sleep-related disorders
US7510531B2 (en) * 2003-09-18 2009-03-31 Cardiac Pacemakers, Inc. System and method for discrimination of central and obstructive disordered breathing events
US7575553B2 (en) * 2003-09-18 2009-08-18 Cardiac Pacemakers, Inc. Methods and systems for assessing pulmonary disease
US20060167523A1 (en) * 2003-10-15 2006-07-27 Tehrani Amir J Device and method for improving upper airway functionality
US20050085874A1 (en) * 2003-10-17 2005-04-21 Ross Davis Method and system for treating sleep apnea
US7319900B2 (en) * 2003-12-11 2008-01-15 Cardiac Pacemakers, Inc. Cardiac response classification using multiple classification windows
US7774064B2 (en) 2003-12-12 2010-08-10 Cardiac Pacemakers, Inc. Cardiac response classification using retriggerable classification windows
US8521284B2 (en) 2003-12-12 2013-08-27 Cardiac Pacemakers, Inc. Cardiac response classification using multisite sensing and pacing
US7421296B1 (en) * 2004-01-26 2008-09-02 Pacesetter, Inc. Termination of respiratory oscillations characteristic of Cheyne-Stokes respiration
US7363085B1 (en) * 2004-01-26 2008-04-22 Pacesetters, Inc. Augmenting hypoventilation
US20050197588A1 (en) * 2004-03-04 2005-09-08 Scott Freeberg Sleep disordered breathing alert system
US7751894B1 (en) * 2004-03-04 2010-07-06 Cardiac Pacemakers, Inc. Systems and methods for indicating aberrant behavior detected by an implanted medical device
US7371220B1 (en) * 2004-06-30 2008-05-13 Pacesetter, Inc. System and method for real-time apnea/hypopnea detection using an implantable medical system
US8473058B2 (en) * 2004-11-22 2013-06-25 Mitsuru Sasaki Apnea preventing stimulation apparatus
KR101133807B1 (en) * 2004-11-22 2012-04-05 미츠루 사사키 Simulator for preventing apnea
US20060122661A1 (en) * 2004-12-03 2006-06-08 Mandell Lee J Diaphragmatic pacing with activity monitor adjustment
US7966072B2 (en) * 2005-02-18 2011-06-21 Palo Alto Investors Methods and compositions for treating obesity-hypoventilation syndrome
US7680534B2 (en) 2005-02-28 2010-03-16 Cardiac Pacemakers, Inc. Implantable cardiac device with dyspnea measurement
US7404799B1 (en) * 2005-04-05 2008-07-29 Pacesetter, Inc. System and method for detection of respiration patterns via integration of intracardiac electrogram signals
US7314451B2 (en) 2005-04-25 2008-01-01 Earlysense Ltd. Techniques for prediction and monitoring of clinical episodes
US7392086B2 (en) 2005-04-26 2008-06-24 Cardiac Pacemakers, Inc. Implantable cardiac device and method for reduced phrenic nerve stimulation
US20060247693A1 (en) 2005-04-28 2006-11-02 Yanting Dong Non-captured intrinsic discrimination in cardiac pacing response classification
US7499751B2 (en) * 2005-04-28 2009-03-03 Cardiac Pacemakers, Inc. Cardiac signal template generation using waveform clustering
US8900154B2 (en) * 2005-05-24 2014-12-02 Cardiac Pacemakers, Inc. Prediction of thoracic fluid accumulation
US7644714B2 (en) 2005-05-27 2010-01-12 Apnex Medical, Inc. Devices and methods for treating sleep disorders
US8364455B2 (en) * 2005-06-09 2013-01-29 Maquet Critical Care Ab Simulator for use with a breathing-assist device
US8036750B2 (en) * 2005-06-13 2011-10-11 Cardiac Pacemakers, Inc. System for neural control of respiration
JP2009515174A (en) * 2005-11-04 2009-04-09 レスメド・リミテッドResmed Ltd Method and apparatus for supporting the diagnosis and management of sleep-disordered breathing
US20090036947A1 (en) * 2006-11-17 2009-02-05 Westlund Randy W Transvenous Phrenic Nerve Stimulation System
US7766840B2 (en) * 2005-12-01 2010-08-03 Cardiac Pacemakers, Inc. Method and system for heart failure status evaluation based on a disordered breathing index
EP1960040B1 (en) * 2005-12-01 2017-02-08 Second Sight Medical Products, Inc. Fitting a neural prosthesis using impedance and electrode height
US8281792B2 (en) * 2005-12-31 2012-10-09 John W Royalty Electromagnetic diaphragm assist device and method for assisting a diaphragm function
US8021310B2 (en) 2006-04-21 2011-09-20 Nellcor Puritan Bennett Llc Work of breathing display for a ventilation system
CA2653442A1 (en) 2006-05-23 2007-11-29 Publiekrechtelijke Rechtspersoon Academisch Ziekenhuis Leiden H.O.D.N. Leids Universitair Medisch Centrum Medical probe
KR100845464B1 (en) * 2006-06-14 2008-07-10 (주)머티리얼솔루션테크놀로지 Implantable diaphragm stimulator and breathing pacemaker using the same
US20080071185A1 (en) * 2006-08-08 2008-03-20 Cardiac Pacemakers, Inc. Periodic breathing during activity
US8226570B2 (en) 2006-08-08 2012-07-24 Cardiac Pacemakers, Inc. Respiration monitoring for heart failure using implantable device
US8103341B2 (en) 2006-08-25 2012-01-24 Cardiac Pacemakers, Inc. System for abating neural stimulation side effects
US8050765B2 (en) * 2006-08-30 2011-11-01 Cardiac Pacemakers, Inc. Method and apparatus for controlling neural stimulation during disordered breathing
US8121692B2 (en) 2006-08-30 2012-02-21 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation with respiratory feedback
JP5236647B2 (en) * 2006-09-11 2013-07-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Electrode placement system and method to the patient's body
US8209013B2 (en) 2006-09-14 2012-06-26 Cardiac Pacemakers, Inc. Therapeutic electrical stimulation that avoids undesirable activation
US7784461B2 (en) 2006-09-26 2010-08-31 Nellcor Puritan Bennett Llc Three-dimensional waveform display for a breathing assistance system
US20080072902A1 (en) * 2006-09-27 2008-03-27 Nellcor Puritan Bennett Incorporated Preset breath delivery therapies for a breathing assistance system
US9186511B2 (en) 2006-10-13 2015-11-17 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
EP2478931B1 (en) 2006-10-13 2015-12-30 Cyberonics, Inc. Obstructive sleep apnea treatment device
US8983609B2 (en) 2007-05-30 2015-03-17 The Cleveland Clinic Foundation Apparatus and method for treating pulmonary conditions
EP2107920B1 (en) 2007-01-29 2013-07-10 Simon Fraser University Transvascular nerve stimulation apparatus
WO2008095108A1 (en) * 2007-02-01 2008-08-07 Ls Biopath, Inc. Electrical systems for detection and characterization of abnormal tissue and cells
US9566030B2 (en) * 2007-02-01 2017-02-14 Ls Biopath, Inc. Optical system for detection and characterization of abnormal tissue and cells
US8417351B2 (en) * 2007-02-09 2013-04-09 Mayo Foundation For Medical Education And Research Peripheral oxistimulator apparatus and methods
US20080228093A1 (en) * 2007-03-13 2008-09-18 Yanting Dong Systems and methods for enhancing cardiac signal features used in morphology discrimination
US20080243016A1 (en) * 2007-03-28 2008-10-02 Cardiac Pacemakers, Inc. Pulmonary Artery Pressure Signals And Methods of Using
US7950560B2 (en) * 2007-04-13 2011-05-31 Tyco Healthcare Group Lp Powered surgical instrument
US20090024176A1 (en) * 2007-07-17 2009-01-22 Joonkyoo Anthony Yun Methods and devices for producing respiratory sinus arrhythmia
US20090024047A1 (en) * 2007-07-20 2009-01-22 Cardiac Pacemakers, Inc. Devices and methods for respiration therapy
US9037239B2 (en) 2007-08-07 2015-05-19 Cardiac Pacemakers, Inc. Method and apparatus to perform electrode combination selection
US8265736B2 (en) 2007-08-07 2012-09-11 Cardiac Pacemakers, Inc. Method and apparatus to perform electrode combination selection
RU2506961C2 (en) * 2007-08-22 2014-02-20 Дзе Рисерч Фаундейшн Оф Стейт Юниверсити Оф Нью Йорк System and method for supply and shared use of breathing gas
WO2009049278A1 (en) 2007-10-12 2009-04-16 Patientslikeme, Inc. Self-improving method of using online communities to predict health-related outcomes
US20170188940A9 (en) * 2007-11-26 2017-07-06 Whispersom Corporation Device to detect and treat Apneas and Hypopnea
US8155744B2 (en) 2007-12-13 2012-04-10 The Cleveland Clinic Foundation Neuromodulatory methods for treating pulmonary disorders
EP2254661B1 (en) 2008-02-14 2015-10-07 Cardiac Pacemakers, Inc. Apparatus for phrenic stimulation detection
CA2724335A1 (en) * 2008-05-15 2009-11-19 Inspire Medical Systems, Inc. Method and apparatus for sensing respiratory pressure in an implantable stimulation system
US8229566B2 (en) * 2008-06-25 2012-07-24 Sheng Li Method and apparatus of breathing-controlled electrical stimulation for skeletal muscles
US8302602B2 (en) 2008-09-30 2012-11-06 Nellcor Puritan Bennett Llc Breathing assistance system with multiple pressure sensors
JP5547200B2 (en) 2008-10-01 2014-07-09 インスパイア・メディカル・システムズ・インコーポレイテッドInspire Medical Systems, Inc. Transvenous method for the treatment of sleep apnea
US20100087893A1 (en) * 2008-10-03 2010-04-08 Solange Pasquet Operant Conditioning-Based Device for Snoring and Obstructive Sleep Apnea and Method of Use
US8644939B2 (en) * 2008-11-18 2014-02-04 Neurostream Technologies General Partnership Method and device for the detection, identification and treatment of sleep apnea/hypopnea
JP5575789B2 (en) * 2008-11-19 2014-08-20 インスパイア・メディカル・システムズ・インコーポレイテッドInspire Medical Systems, Inc. A method of treatment of sleep-disordered breathing
EP2198779A1 (en) * 2008-12-22 2010-06-23 Sendsor GmbH Device and method for early detection of exacerbations
US9744354B2 (en) 2008-12-31 2017-08-29 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
US20100204567A1 (en) * 2009-02-09 2010-08-12 The Cleveland Clinic Foundation Ultrasound-guided delivery of a therapy delivery device to a phrenic nerve
US8870773B2 (en) * 2009-02-09 2014-10-28 The Cleveland Clinic Foundation Ultrasound-guided delivery of a therapy delivery device to a nerve target
EP2416845B1 (en) 2009-03-31 2015-03-18 Inspire Medical Systems, Inc. Percutaneous access for systems of treating sleep-related disordered breathing
US8378832B2 (en) * 2009-07-09 2013-02-19 Harry J. Cassidy Breathing disorder treatment system and method
EP2453975B1 (en) * 2009-07-15 2016-11-02 Cardiac Pacemakers, Inc. Remote sensing in an implantable medical device
EP2453977B1 (en) 2009-07-15 2017-11-08 Cardiac Pacemakers, Inc. Physiological vibration detection in an implanted medical device
EP2454697A2 (en) 2009-07-15 2012-05-23 Cardiac Pacemakers, Inc. Remote pace detection in an implantable medical device
US20120165623A1 (en) * 2009-08-28 2012-06-28 Lawrence Allan Lynn Relational Thermorespirometer Spot Vitals Monitor
US9072899B1 (en) * 2009-09-04 2015-07-07 Todd Nickloes Diaphragm pacemaker
US8574145B2 (en) * 2009-09-14 2013-11-05 Sleep Methods, Inc. System and method for training and promoting a conditioned reflex intervention during sleep
US8409108B2 (en) * 2009-11-05 2013-04-02 Inovise Medical, Inc. Multi-axial heart sounds and murmur detection for hemodynamic-condition assessment
US8335992B2 (en) 2009-12-04 2012-12-18 Nellcor Puritan Bennett Llc Visual indication of settings changes on a ventilator graphical user interface
USD649157S1 (en) 2009-12-04 2011-11-22 Nellcor Puritan Bennett Llc Ventilator display screen with a user interface
USD638852S1 (en) 2009-12-04 2011-05-31 Nellcor Puritan Bennett Llc Ventilator display screen with an alarm icon
US9119925B2 (en) 2009-12-04 2015-09-01 Covidien Lp Quick initiation of respiratory support via a ventilator user interface
US8924878B2 (en) 2009-12-04 2014-12-30 Covidien Lp Display and access to settings on a ventilator graphical user interface
US9262588B2 (en) 2009-12-18 2016-02-16 Covidien Lp Display of respiratory data graphs on a ventilator graphical user interface
US8499252B2 (en) 2009-12-18 2013-07-30 Covidien Lp Display of respiratory data graphs on a ventilator graphical user interface
JP2011213096A (en) * 2010-03-19 2011-10-27 Makita Corp Power tool
US8983572B2 (en) 2010-10-29 2015-03-17 Inspire Medical Systems, Inc. System and method for patient selection in treating sleep disordered breathing
KR20120046554A (en) * 2010-11-02 2012-05-10 연세대학교 산학협력단 Sensor for detecting cancer tissue and manufacturing method of the same
US9457186B2 (en) 2010-11-15 2016-10-04 Bluewind Medical Ltd. Bilateral feedback
US9186504B2 (en) 2010-11-15 2015-11-17 Rainbow Medical Ltd Sleep apnea treatment
US9717868B2 (en) * 2010-11-23 2017-08-01 Koninklijke Philips N.V. Obesity hypventilation syndrome treatment system and method
US9205262B2 (en) 2011-05-12 2015-12-08 Cyberonics, Inc. Devices and methods for sleep apnea treatment
US8855771B2 (en) 2011-01-28 2014-10-07 Cyberonics, Inc. Screening devices and methods for obstructive sleep apnea therapy
US9913982B2 (en) 2011-01-28 2018-03-13 Cyberonics, Inc. Obstructive sleep apnea treatment devices, systems and methods
US9744349B2 (en) 2011-02-10 2017-08-29 Respicardia, Inc. Medical lead and implantation
WO2012167266A1 (en) * 2011-06-03 2012-12-06 Children's Hospital Los Angeles Electrophysiological diagnosis and treatment for asthma
US8706235B2 (en) 2011-07-27 2014-04-22 Medtronic, Inc. Transvenous method to induce respiration
US8478413B2 (en) 2011-07-27 2013-07-02 Medtronic, Inc. Bilateral phrenic nerve stimulation with reduced dyssynchrony
US20130053717A1 (en) * 2011-08-30 2013-02-28 Nellcor Puritan Bennett Llc Automatic ventilator challenge to induce spontaneous breathing efforts
US8934992B2 (en) 2011-09-01 2015-01-13 Inspire Medical Systems, Inc. Nerve cuff
US8855783B2 (en) 2011-09-09 2014-10-07 Enopace Biomedical Ltd. Detector-based arterial stimulation
US9364624B2 (en) 2011-12-07 2016-06-14 Covidien Lp Methods and systems for adaptive base flow
US9498589B2 (en) 2011-12-31 2016-11-22 Covidien Lp Methods and systems for adaptive base flow and leak compensation
EP2807412B1 (en) 2012-01-26 2017-08-02 MED-EL Elektromedizinische Geräte GmbH Neural monitoring systems for treating pharyngeal disorders
CA2862867A1 (en) * 2012-01-27 2013-08-01 T4 Analytics Llc Anesthesia monitoring systems and methods of monitoring anesthesia
US8844526B2 (en) 2012-03-30 2014-09-30 Covidien Lp Methods and systems for triggering with unknown base flow
EP2863987A4 (en) 2012-06-21 2016-07-27 Univ Fraser Simon Transvascular diaphragm pacing systems and methods of use
WO2014008171A1 (en) * 2012-07-02 2014-01-09 Medisci L.L.C. Method and device for respiratory and cardiorespiratory support
CN102949770B (en) * 2012-11-09 2015-04-22 张红璇 External diaphragm pacing and breathing machine synergistic air supply method and device thereof
CN104994906B (en) * 2012-12-19 2017-05-24 维斯卡迪亚公司 Improve hemodynamic function by stimulating the diaphragm asymptomatic
CN103055417B (en) * 2012-12-31 2015-09-09 中国人民解放军第三军医大学第一附属医院 A non-invasive transcutaneous electrical stimulator
US20150025395A1 (en) * 2013-04-15 2015-01-22 Yonglin Biotech Corp. Breathing analysis method, system, and apparatus
US9242088B2 (en) 2013-11-22 2016-01-26 Simon Fraser University Apparatus and methods for assisted breathing by transvascular nerve stimulation
US9333363B2 (en) * 2014-01-21 2016-05-10 Simon Fraser University Systems and related methods for optimization of multi-electrode nerve pacing
US20160361012A1 (en) * 2014-02-25 2016-12-15 Somnics, Inc Methods and applications for detection of breath flow and the system thereof
US20150283382A1 (en) * 2014-04-04 2015-10-08 Med-El Elektromedizinische Geraete Gmbh Respiration Sensors For Recording Of Triggered Respiratory Signals In Neurostimulators
US9808591B2 (en) 2014-08-15 2017-11-07 Covidien Lp Methods and systems for breath delivery synchronization
US9925346B2 (en) 2015-01-20 2018-03-27 Covidien Lp Systems and methods for ventilation with unknown exhalation flow
EP3064131A1 (en) * 2015-03-03 2016-09-07 BIOTRONIK SE & Co. KG Combined vagus-phrenic nerve stimulation apparatus
US9839786B2 (en) * 2015-04-17 2017-12-12 Inspire Medical Systems, Inc. System and method of monitoring for and reporting on patient-made stimulation therapy programming changes
US20170202509A1 (en) * 2016-01-20 2017-07-20 Soniphi Llc Frequency Analysis Feedback Systems and Methods
CN105879223B (en) * 2016-04-22 2017-02-08 广州雪利昂生物科技有限公司 Method and apparatus for surface EMG signal as a synchronization signal to trigger external diaphragm pacemakers
WO2018026346A1 (en) * 2016-08-01 2018-02-08 Med-El Elektromedizinische Geraete Gmbh Respiratory triggered parasternal electromyographic recording in neurostimulators

Citations (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4827935A (en) * 1986-04-24 1989-05-09 Purdue Research Foundation Demand electroventilator
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
US5146918A (en) * 1991-03-19 1992-09-15 Medtronic, Inc. Demand apnea control of central and obstructive sleep apnea
US5211173A (en) * 1991-01-09 1993-05-18 Medtronic, Inc. Servo muscle control
US5215082A (en) * 1991-04-02 1993-06-01 Medtronic, Inc. Implantable apnea generator with ramp on generator
US5233983A (en) * 1991-09-03 1993-08-10 Medtronic, Inc. Method and apparatus for apnea patient screening
US5281219A (en) * 1990-11-23 1994-01-25 Medtronic, Inc. Multiple stimulation electrodes
US5300094A (en) * 1991-01-09 1994-04-05 Medtronic, Inc. Servo muscle control
US5423372A (en) * 1993-12-27 1995-06-13 Ford Motor Company Joining sand cores for making castings
US5423327A (en) * 1989-02-21 1995-06-13 Clauson; William L. Method for automatic stimulation of mammels in response to blood gas analysis
US5483969A (en) * 1994-09-21 1996-01-16 Medtronic, Inc. Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea
US5485851A (en) * 1994-09-21 1996-01-23 Medtronic, Inc. Method and apparatus for arousal detection
US5522862A (en) * 1994-09-21 1996-06-04 Medtronic, Inc. Method and apparatus for treating obstructive sleep apnea
US5524632A (en) * 1994-01-07 1996-06-11 Medtronic, Inc. Method for implanting electromyographic sensing electrodes
US5540731A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for pressure detecting and treating obstructive airway disorders
US5540733A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for detecting and treating obstructive sleep apnea
US5540732A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for impedance detecting and treating obstructive airway disorders
US5546952A (en) * 1994-09-21 1996-08-20 Medtronic, Inc. Method and apparatus for detection of a respiratory waveform
US5549655A (en) * 1994-09-21 1996-08-27 Medtronic, Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US5766228A (en) * 1995-10-13 1998-06-16 Ela Medical S.A. Enslaved active implantable medical device with reduced power consumption
US5797923A (en) * 1997-05-12 1998-08-25 Aiyar; Harish Electrode delivery instrument
US5800470A (en) * 1994-01-07 1998-09-01 Medtronic, Inc. Respiratory muscle electromyographic rate responsive pacemaker
US5876353A (en) * 1997-01-31 1999-03-02 Medtronic, Inc. Impedance monitor for discerning edema through evaluation of respiratory rate
US5895360A (en) * 1996-06-26 1999-04-20 Medtronic, Inc. Gain control for a periodic signal and method regarding same
US5911218A (en) * 1995-04-21 1999-06-15 Dimarco; Anthony Fortunato Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient
US5944680A (en) * 1996-06-26 1999-08-31 Medtronic, Inc. Respiratory effort detection method and apparatus
US6021352A (en) * 1996-06-26 2000-02-01 Medtronic, Inc, Diagnostic testing methods and apparatus for implantable therapy devices
US6099479A (en) * 1996-06-26 2000-08-08 Medtronic, Inc. Method and apparatus for operating therapy system
US6212435B1 (en) * 1998-11-13 2001-04-03 Respironics, Inc. Intraoral electromuscular stimulation device and method
US6224562B1 (en) * 1998-06-11 2001-05-01 Cprx Llc Methods and devices for performing cardiopulmonary resuscitation
US6251126B1 (en) * 1998-04-23 2001-06-26 Medtronic Inc Method and apparatus for synchronized treatment of obstructive sleep apnea
US6269269B1 (en) * 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6345202B2 (en) * 1998-08-14 2002-02-05 Advanced Bionics Corporation Method of treating obstructive sleep apnea using implantable electrodes
US20020049482A1 (en) * 2000-06-14 2002-04-25 Willa Fabian Lifestyle management system
US6415183B1 (en) * 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US6512949B1 (en) * 1999-07-12 2003-01-28 Medtronic, Inc. Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto
US6527729B1 (en) * 1999-11-10 2003-03-04 Pacesetter, Inc. Method for monitoring patient using acoustic sensor
US6542774B2 (en) * 1996-04-30 2003-04-01 Medtronic, Inc. Method and device for electronically controlling the beating of a heart
US6572543B1 (en) * 1996-06-26 2003-06-03 Medtronic, Inc Sensor, method of sensor implant and system for treatment of respiratory disorders
US6574507B1 (en) * 1998-07-06 2003-06-03 Ela Medical S.A. Active implantable medical device for treating sleep apnea syndrome by electrostimulation
US6589188B1 (en) * 2000-05-05 2003-07-08 Pacesetter, Inc. Method for monitoring heart failure via respiratory patterns
US20030127091A1 (en) * 1999-12-15 2003-07-10 Chang Yung Chi Scientific respiration for self-health-care
US6600949B1 (en) * 1999-11-10 2003-07-29 Pacesetter, Inc. Method for monitoring heart failure via respiratory patterns
US20030153954A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Sleep apnea therapy device using dynamic overdrive pacing
US20030153956A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Cardiac stimulation device including sleep apnea prevention and treatment
US20030153955A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Cardiac stimulation device including sleep apnea prevention and treatment
US20040059240A1 (en) * 2001-04-30 2004-03-25 Medtronic, Inc. Method and apparatus to detect and treat sleep respiratory events
US20040077953A1 (en) * 2002-10-18 2004-04-22 Turcott Robert G. Hemodynamic analysis
US6731984B2 (en) * 2001-06-07 2004-05-04 Medtronic, Inc. Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same
US20040088015A1 (en) * 2002-10-31 2004-05-06 Casavant David A. Respiratory nerve stimulation
US20040111040A1 (en) * 2002-12-04 2004-06-10 Quan Ni Detection of disordered breathing
US6752765B1 (en) * 1999-12-01 2004-06-22 Medtronic, Inc. Method and apparatus for monitoring heart rate and abnormal respiration
US20040122484A1 (en) * 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for defining, identifying and using predetermined health-related events
US20040134496A1 (en) * 2003-01-10 2004-07-15 Cho Yong K. Method and apparatus for detecting respiratory disturbances
US20040138719A1 (en) * 2003-01-10 2004-07-15 Cho Yong K. System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing
US20040176809A1 (en) * 2001-06-07 2004-09-09 Medtronic, Inc. Method and apparatus for modifying delivery of a therapy in response to onset of sleep
US20050021102A1 (en) * 2003-07-23 2005-01-27 Ignagni Anthony R. System and method for conditioning a diaphragm of a patient
US20050043772A1 (en) * 2003-08-18 2005-02-24 Stahmann Jeffrey E. Therapy triggered by prediction of disordered breathing
US20050039745A1 (en) * 2003-08-18 2005-02-24 Stahmann Jeffrey E. Adaptive therapy for disordered breathing
US20050043644A1 (en) * 2003-08-18 2005-02-24 Stahmann Jeffrey E. Prediction of disordered breathing
US20050055060A1 (en) * 2003-09-05 2005-03-10 Steve Koh Determination of respiratory characteristics from AV conduction intervals
US20050065567A1 (en) * 2003-09-18 2005-03-24 Cardiac Pacemakers, Inc. Therapy control based on cardiopulmonary status
US20050065563A1 (en) * 2003-09-23 2005-03-24 Avram Scheiner Paced ventilation therapy by an implantable cardiac device
US20050061315A1 (en) * 2003-09-18 2005-03-24 Kent Lee Feedback system and method for sleep disordered breathing therapy
US20050061319A1 (en) * 2003-09-18 2005-03-24 Cardiac Pacemakers, Inc. Methods and systems for implantably monitoring external breathing therapy
US20050061320A1 (en) * 2003-09-18 2005-03-24 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US20050074741A1 (en) * 2003-09-18 2005-04-07 Kent Lee System and method for discrimination of central and obstructive disordered breathing events
US20050076909A1 (en) * 2003-09-18 2005-04-14 Stahmann Jeffrey E. Synergistic use of medical devices for detecting medical disorders
US20050080461A1 (en) * 2003-09-18 2005-04-14 Stahmann Jeffrey E. System and method for moderating a therapy delivered during sleep using physiologic data acquired during non-sleep
US6881192B1 (en) * 2002-06-12 2005-04-19 Pacesetter, Inc. Measurement of sleep apnea duration and evaluation of response therapies using duration metrics
US20050085867A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. System and method for diaphragm stimulation
US20050101833A1 (en) * 2003-09-02 2005-05-12 Biotronik Gmbh & Co. Kg Apparatus for the treatment of sleep apnea
US20050107860A1 (en) * 2003-07-23 2005-05-19 Ignagni Anthony R. Mapping probe system for neuromuscular electrical stimulation apparatus
US20050115561A1 (en) * 2003-08-18 2005-06-02 Stahmann Jeffrey E. Patient monitoring, diagnosis, and/or therapy systems and methods
US20050119711A1 (en) * 2003-01-10 2005-06-02 Cho Yong K. Apparatus and method for monitoring for disordered breathing
US6908437B2 (en) * 1999-11-16 2005-06-21 Cardiac Intelligence Corporation System and method for diagnosing and monitoring congestive heart failure for automated remote patient care
US20050148897A1 (en) * 2003-12-24 2005-07-07 Cho Yong K. Implantable medical device with sleep disordered breathing monitoring
US20050145246A1 (en) * 2003-09-18 2005-07-07 Hartley Jesse W. Posture detection system and method
US20050165457A1 (en) * 2004-01-26 2005-07-28 Michael Benser Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration
US20060058852A1 (en) * 2004-09-10 2006-03-16 Steve Koh Multi-variable feedback control of stimulation for inspiratory facilitation
US20060064030A1 (en) * 1999-04-16 2006-03-23 Cosentino Daniel L System, method, and apparatus for combining information from an implanted device with information from a patient monitoring apparatus
US20060064325A1 (en) * 2002-10-02 2006-03-23 Suzuken Co., Ltd Health management system, activity status measusring device, and data processing device
US7058453B2 (en) * 1999-12-14 2006-06-06 Medtronic, Inc. Apparatus and method for remote therapy and diagnosis in medical devices via interface systems
US20060122622A1 (en) * 2004-12-06 2006-06-08 Csaba Truckai Bone treatment systems and methods
US20060142815A1 (en) * 2003-10-15 2006-06-29 Tehrani Amir J Device and method for treating obstructive sleep apnea
US7070568B1 (en) * 2004-03-02 2006-07-04 Pacesetter, Inc. System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device
US20060149334A1 (en) * 2003-10-15 2006-07-06 Tehrani Amir J Device and method for controlling breathing
US20060155341A1 (en) * 2003-10-15 2006-07-13 Tehrani Amir J Device and method for biasing lung volume
US7082331B1 (en) * 2004-04-21 2006-07-25 Pacesetter, Inc. System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
US20060167523A1 (en) * 2003-10-15 2006-07-27 Tehrani Amir J Device and method for improving upper airway functionality

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US345202A (en) * 1886-07-06 Treating lac
US193697A (en) * 1877-07-31 Improvement in mowers
US85869A (en) * 1869-01-12 Improvement in horse-rakes
US142815A (en) * 1873-09-16 Improvement in car-couplings
US56519A (en) * 1866-07-24 Improvement in clamps for holding saws
US176809A (en) * 1876-05-02 Improvement in machinery for cutting waved edges on leather
US77953A (en) * 1868-05-19 b i c k e
US225226A (en) * 1880-03-09 Rotary engine
US85866A (en) * 1869-01-12 Improved bed-bottom
US204213A (en) * 1878-05-28 Improvement in loom-pickers
US167523A (en) * 1875-09-07 Improvement in sole-channeling machines
US215082A (en) * 1879-05-06 Improvement in type-writing machines
US237963A (en) * 1881-02-22 Manufacture of sheet-iron
US61320A (en) * 1867-01-22 of lewiston
US65567A (en) * 1867-06-11 Improved soeew machine
US281219A (en) * 1883-07-10 Half to alonzo e
US85734A (en) * 1869-01-12 Improvement in gr
US115561A (en) * 1871-06-06 Improvement in electro-sviagnetic separators
US300094A (en) * 1884-06-10 Machine
US148897A (en) * 1874-03-24 Improvement in machines for pressing pantaloons
US540732A (en) * 1895-06-11 Martin freund
US211173A (en) * 1879-01-07 Improvement in wagon-tracks for roads
US85868A (en) * 1869-01-12 Improvement in steam water-elevators
US85865A (en) * 1869-01-12 Improvement in threshing-knives
US240240A (en) * 1881-04-19 Beer-faucet
US99479A (en) * 1870-02-01 Edwin r
US127091A (en) * 1872-05-21 Improvement in spark-arresters
US61319A (en) * 1867-01-22 Improvement in pumps
US540731A (en) * 1895-06-11 Wire-reel
US39745A (en) * 1863-09-01 Improvement in hoisting apparatus
US574507A (en) * 1897-01-05 Account-keeping book
US21795A (en) * 1858-10-12 Improvement in cotton-gins
US138719A (en) * 1873-05-06 Improvement in fly-switches
US174287A (en) * 1876-02-29 Improvement in tool-holders
US149334A (en) * 1874-04-07 Improvement in railroad-frogs
US122622A (en) * 1872-01-09 Improvement in compartment-cars for railways
US540733A (en) * 1895-06-11 Ernst gerstenberg and herman barghausen
US155341A (en) * 1874-09-22 Improvement in fertilizers
US88015A (en) * 1869-03-23 Improvement in lifting-jacks
US101833A (en) * 1870-04-12 Improved coal-box
US522862A (en) * 1894-07-10 Sawhorse
US111040A (en) * 1871-01-17 Improvement in fluid-meters
US36294A (en) * 1862-08-26 Improved portable sugar-evaporatx
US74741A (en) * 1868-02-18 George w
US59240A (en) * 1866-10-30 Maeshall t
US85867A (en) * 1869-01-12 Improvement in blind-fastener
US119711A (en) * 1871-10-10 Improvement in staple-machines
US55060A (en) * 1866-05-29 Improvement in harvester-rakes
US65563A (en) * 1867-06-11 Julius hackert
US247729A (en) * 1881-09-27 Corset-stay
US61315A (en) * 1867-01-22 Improved apparatus for decomposing animal and vegetable substances
US146918A (en) * 1874-01-27 Improvement in car-couplings
US681192A (en) * 1900-11-19 1901-08-27 Natural Food Company Marking-machine.
US678535A (en) * 1901-02-02 1901-07-16 Austen Bigg Hoe.
US911218A (en) * 1908-02-17 1909-02-02 Elias B Wrenn Trace-holder.
US1496918A (en) * 1922-08-23 1924-06-10 Frederick M Baldwin Signaling device for vehicles
US3773051A (en) 1972-03-01 1973-11-20 Research Corp Method and apparatus for stimulation of body tissue
US4146918A (en) * 1978-01-18 1979-03-27 Albert Tureck Photographic flash reflector and diffuser system
US5056519A (en) 1990-05-14 1991-10-15 Vince Dennis J Unilateral diaphragmatic pacer
US5265604A (en) 1990-05-14 1993-11-30 Vince Dennis J Demand - diaphragmatic pacing (skeletal muscle pressure modified)
US5190036A (en) * 1991-02-28 1993-03-02 Linder Steven H Abdominal binder for effectuating cough stimulation
US5174287A (en) 1991-05-28 1992-12-29 Medtronic, Inc. Airway feedback measurement system responsive to detected inspiration and obstructive apnea event
US5572543A (en) 1992-04-09 1996-11-05 Deutsch Aerospace Ag Laser system with a micro-mechanically moved mirror
FR2739760B1 (en) * 1995-10-11 1997-12-12 Salomon Sa Method and device for heating a shoe inner lining
DE69727878T2 (en) 1996-10-18 2005-01-05 St. Jude Medical Ab An apparatus for the treatment of tachycardia by stimulation of the respiratory system
US5830008A (en) 1996-12-17 1998-11-03 The Whitaker Corporation Panel mountable connector
WO1999020339A1 (en) 1997-10-17 1999-04-29 Respironics, Inc. Muscle stimulating device and method for diagnosing and treating a breathing disorder
US6021362A (en) * 1998-02-17 2000-02-01 Maggard; Karl J. Method and apparatus for dispensing samples and premiums
CN101333244B (en) 1998-05-06 2013-12-18 基因技术股份有限公司 Protein purification by ion exchange chromatography
DE69937492T2 (en) 1998-05-22 2008-08-21 ResMed Ltd., Bella Vista Assisted mechanical ventilation in the treatment of heart failure and Cheyne-Stokes respiration
US6463327B1 (en) * 1998-06-11 2002-10-08 Cprx Llc Stimulatory device and methods to electrically stimulate the phrenic nerve
US6312399B1 (en) 1998-06-11 2001-11-06 Cprx, Llc Stimulatory device and methods to enhance venous blood return during cardiopulmonary resuscitation
JP2002519121A (en) * 1998-06-30 2002-07-02 シーメンス−エレマ アクチボラゲット Respiratory support system
WO2000006249A3 (en) * 1998-07-27 2000-05-18 Dominique Durand Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea
US6314324B1 (en) 1999-05-05 2001-11-06 Respironics, Inc. Vestibular stimulation system and method
US6480733B1 (en) 1999-11-10 2002-11-12 Pacesetter, Inc. Method for monitoring heart failure
US6710094B2 (en) * 1999-12-29 2004-03-23 Styrochem Delaware, Inc. Processes for preparing patterns for use in metal castings
US6666830B1 (en) 2000-08-17 2003-12-23 East River Ventures, Lp System and method for detecting the onset of an obstructive sleep apnea event
US6357438B1 (en) * 2000-10-19 2002-03-19 Mallinckrodt Inc. Implantable sensor for proportional assist ventilation
US6633779B1 (en) 2000-11-27 2003-10-14 Science Medicus, Inc. Treatment of asthma and respiratory disease by means of electrical neuro-receptive waveforms
US6572949B1 (en) * 2001-08-30 2003-06-03 Carlton Paul Lewis Paint mask and method of using
FR2829917B1 (en) 2001-09-24 2004-06-11 Ela Medical Sa Active medical device comprising diagnostic means respiratory profile
US20030195571A1 (en) 2002-04-12 2003-10-16 Burnes John E. Method and apparatus for the treatment of central sleep apnea using biventricular pacing
US20030204213A1 (en) 2002-04-30 2003-10-30 Jensen Donald N. Method and apparatus to detect and monitor the frequency of obstructive sleep apnea
US20030225339A1 (en) 2002-05-06 2003-12-04 Respironics Novametrix Methods for inducing temporary changes in ventilation for estimation of hemodynamic performance
EP1393773B1 (en) * 2002-08-28 2006-10-18 Maquet Critical Care AB Nerve stimulation device
JP4095391B2 (en) * 2002-09-24 2008-06-04 キヤノン株式会社 Position detection method
US8672852B2 (en) * 2002-12-13 2014-03-18 Intercure Ltd. Apparatus and method for beneficial modification of biorhythmic activity
US20050020240A1 (en) * 2003-02-07 2005-01-27 Darin Minter Private wireless network
US20050261747A1 (en) 2003-05-16 2005-11-24 Schuler Eleanor L Method and system to control respiration by means of neuro-electrical coded signals
US6905788B2 (en) * 2003-09-12 2005-06-14 Eastman Kodak Company Stabilized OLED device
US7532934B2 (en) * 2003-09-18 2009-05-12 Cardiac Pacemakers, Inc. Snoring detection system and method
US9259573B2 (en) * 2003-10-15 2016-02-16 Rmx, Llc Device and method for manipulating exhalation
US8265759B2 (en) 2003-10-15 2012-09-11 Rmx, Llc Device and method for treating disorders of the cardiovascular system or heart
US20080161878A1 (en) 2003-10-15 2008-07-03 Tehrani Amir J Device and method to for independently stimulating hemidiaphragms
US20120158091A1 (en) * 2003-10-15 2012-06-21 Rmx, Llc Therapeutic diaphragm stimulation device and method
US8160711B2 (en) 2003-10-15 2012-04-17 Rmx, Llc Multimode device and method for controlling breathing
US8140164B2 (en) * 2003-10-15 2012-03-20 Rmx, Llc Therapeutic diaphragm stimulation device and method
EP1680010A4 (en) 2003-11-04 2009-07-01 Quantum Intech Inc Systems and methods for facilitating physiological coherence using respiration training
EP1786315A4 (en) 2004-02-05 2010-03-03 Earlysense Ltd Techniques for prediction and monitoring of respiration-manifested clinical episodes
DE102004016985B4 (en) 2004-04-07 2010-07-22 Pari Pharma Gmbh Aerosol generating device and inhalation device
US7245971B2 (en) 2004-04-21 2007-07-17 Pacesetter, Inc. System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
JP4396380B2 (en) 2004-04-26 2010-01-13 アイシン・エィ・ダブリュ株式会社 Transmitting apparatus and method for transmitting traffic information
US7153271B2 (en) 2004-05-20 2006-12-26 Airmatrix Technologies, Inc. Method and system for diagnosing central versus obstructive apnea
US20060122661A1 (en) * 2004-12-03 2006-06-08 Mandell Lee J Diaphragmatic pacing with activity monitor adjustment
US7680538B2 (en) 2005-03-31 2010-03-16 Case Western Reserve University Method of treating obstructive sleep apnea using electrical nerve stimulation
US8036750B2 (en) 2005-06-13 2011-10-11 Cardiac Pacemakers, Inc. System for neural control of respiration
US20080021506A1 (en) * 2006-05-09 2008-01-24 Massachusetts General Hospital Method and device for the electrical treatment of sleep apnea and snoring
US8280513B2 (en) 2006-12-22 2012-10-02 Rmx, Llc Device and method to treat flow limitations

Patent Citations (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4827935A (en) * 1986-04-24 1989-05-09 Purdue Research Foundation Demand electroventilator
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
US5423327A (en) * 1989-02-21 1995-06-13 Clauson; William L. Method for automatic stimulation of mammels in response to blood gas analysis
US5281219A (en) * 1990-11-23 1994-01-25 Medtronic, Inc. Multiple stimulation electrodes
US5300094A (en) * 1991-01-09 1994-04-05 Medtronic, Inc. Servo muscle control
US5211173A (en) * 1991-01-09 1993-05-18 Medtronic, Inc. Servo muscle control
US5146918A (en) * 1991-03-19 1992-09-15 Medtronic, Inc. Demand apnea control of central and obstructive sleep apnea
US5215082A (en) * 1991-04-02 1993-06-01 Medtronic, Inc. Implantable apnea generator with ramp on generator
US5233983A (en) * 1991-09-03 1993-08-10 Medtronic, Inc. Method and apparatus for apnea patient screening
US5423372A (en) * 1993-12-27 1995-06-13 Ford Motor Company Joining sand cores for making castings
US5524632A (en) * 1994-01-07 1996-06-11 Medtronic, Inc. Method for implanting electromyographic sensing electrodes
US5800470A (en) * 1994-01-07 1998-09-01 Medtronic, Inc. Respiratory muscle electromyographic rate responsive pacemaker
US5485851A (en) * 1994-09-21 1996-01-23 Medtronic, Inc. Method and apparatus for arousal detection
US5522862A (en) * 1994-09-21 1996-06-04 Medtronic, Inc. Method and apparatus for treating obstructive sleep apnea
US5540731A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for pressure detecting and treating obstructive airway disorders
US5540733A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for detecting and treating obstructive sleep apnea
US5540732A (en) * 1994-09-21 1996-07-30 Medtronic, Inc. Method and apparatus for impedance detecting and treating obstructive airway disorders
US5546952A (en) * 1994-09-21 1996-08-20 Medtronic, Inc. Method and apparatus for detection of a respiratory waveform
US5549655A (en) * 1994-09-21 1996-08-27 Medtronic, Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US5483969A (en) * 1994-09-21 1996-01-16 Medtronic, Inc. Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea
US5911218A (en) * 1995-04-21 1999-06-15 Dimarco; Anthony Fortunato Method and apparatus for electrical stimulation of the respiratory muscles to achieve artificial ventilation in a patient
US5766228A (en) * 1995-10-13 1998-06-16 Ela Medical S.A. Enslaved active implantable medical device with reduced power consumption
US6542774B2 (en) * 1996-04-30 2003-04-01 Medtronic, Inc. Method and device for electronically controlling the beating of a heart
US6099479A (en) * 1996-06-26 2000-08-08 Medtronic, Inc. Method and apparatus for operating therapy system
US6572543B1 (en) * 1996-06-26 2003-06-03 Medtronic, Inc Sensor, method of sensor implant and system for treatment of respiratory disorders
US5895360A (en) * 1996-06-26 1999-04-20 Medtronic, Inc. Gain control for a periodic signal and method regarding same
US6021352A (en) * 1996-06-26 2000-02-01 Medtronic, Inc, Diagnostic testing methods and apparatus for implantable therapy devices
US5944680A (en) * 1996-06-26 1999-08-31 Medtronic, Inc. Respiratory effort detection method and apparatus
US5876353A (en) * 1997-01-31 1999-03-02 Medtronic, Inc. Impedance monitor for discerning edema through evaluation of respiratory rate
US5797923A (en) * 1997-05-12 1998-08-25 Aiyar; Harish Electrode delivery instrument
US6251126B1 (en) * 1998-04-23 2001-06-26 Medtronic Inc Method and apparatus for synchronized treatment of obstructive sleep apnea
US6269269B1 (en) * 1998-04-23 2001-07-31 Medtronic Inc. Method and apparatus for synchronized treatment of obstructive sleep apnea
US6224562B1 (en) * 1998-06-11 2001-05-01 Cprx Llc Methods and devices for performing cardiopulmonary resuscitation
US6574507B1 (en) * 1998-07-06 2003-06-03 Ela Medical S.A. Active implantable medical device for treating sleep apnea syndrome by electrostimulation
US6345202B2 (en) * 1998-08-14 2002-02-05 Advanced Bionics Corporation Method of treating obstructive sleep apnea using implantable electrodes
US6212435B1 (en) * 1998-11-13 2001-04-03 Respironics, Inc. Intraoral electromuscular stimulation device and method
US20060064030A1 (en) * 1999-04-16 2006-03-23 Cosentino Daniel L System, method, and apparatus for combining information from an implanted device with information from a patient monitoring apparatus
US6512949B1 (en) * 1999-07-12 2003-01-28 Medtronic, Inc. Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto
US6600949B1 (en) * 1999-11-10 2003-07-29 Pacesetter, Inc. Method for monitoring heart failure via respiratory patterns
US6527729B1 (en) * 1999-11-10 2003-03-04 Pacesetter, Inc. Method for monitoring patient using acoustic sensor
US6908437B2 (en) * 1999-11-16 2005-06-21 Cardiac Intelligence Corporation System and method for diagnosing and monitoring congestive heart failure for automated remote patient care
US6752765B1 (en) * 1999-12-01 2004-06-22 Medtronic, Inc. Method and apparatus for monitoring heart rate and abnormal respiration
US6415183B1 (en) * 1999-12-09 2002-07-02 Cardiac Pacemakers, Inc. Method and apparatus for diaphragmatic pacing
US7058453B2 (en) * 1999-12-14 2006-06-06 Medtronic, Inc. Apparatus and method for remote therapy and diagnosis in medical devices via interface systems
US20030127091A1 (en) * 1999-12-15 2003-07-10 Chang Yung Chi Scientific respiration for self-health-care
US6589188B1 (en) * 2000-05-05 2003-07-08 Pacesetter, Inc. Method for monitoring heart failure via respiratory patterns
US20020049482A1 (en) * 2000-06-14 2002-04-25 Willa Fabian Lifestyle management system
US6735479B2 (en) * 2000-06-14 2004-05-11 Medtronic, Inc. Lifestyle management system
US20040059240A1 (en) * 2001-04-30 2004-03-25 Medtronic, Inc. Method and apparatus to detect and treat sleep respiratory events
US20040176809A1 (en) * 2001-06-07 2004-09-09 Medtronic, Inc. Method and apparatus for modifying delivery of a therapy in response to onset of sleep
US6731984B2 (en) * 2001-06-07 2004-05-04 Medtronic, Inc. Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same
US20030153955A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Cardiac stimulation device including sleep apnea prevention and treatment
US20030153956A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Cardiac stimulation device including sleep apnea prevention and treatment
US20030153954A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Sleep apnea therapy device using dynamic overdrive pacing
US20030153953A1 (en) * 2002-02-14 2003-08-14 Euljoon Park Stimulation device for sleep apnea prevention, detection and treatment
US6881192B1 (en) * 2002-06-12 2005-04-19 Pacesetter, Inc. Measurement of sleep apnea duration and evaluation of response therapies using duration metrics
US20060064325A1 (en) * 2002-10-02 2006-03-23 Suzuken Co., Ltd Health management system, activity status measusring device, and data processing device
US20040077953A1 (en) * 2002-10-18 2004-04-22 Turcott Robert G. Hemodynamic analysis
US20040088015A1 (en) * 2002-10-31 2004-05-06 Casavant David A. Respiratory nerve stimulation
US20040111040A1 (en) * 2002-12-04 2004-06-10 Quan Ni Detection of disordered breathing
US20040122484A1 (en) * 2002-12-18 2004-06-24 John Hatlestad Advanced patient management for defining, identifying and using predetermined health-related events
US20040134496A1 (en) * 2003-01-10 2004-07-15 Cho Yong K. Method and apparatus for detecting respiratory disturbances
US20050119711A1 (en) * 2003-01-10 2005-06-02 Cho Yong K. Apparatus and method for monitoring for disordered breathing
US20040138719A1 (en) * 2003-01-10 2004-07-15 Cho Yong K. System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing
US20050107860A1 (en) * 2003-07-23 2005-05-19 Ignagni Anthony R. Mapping probe system for neuromuscular electrical stimulation apparatus
US20050021102A1 (en) * 2003-07-23 2005-01-27 Ignagni Anthony R. System and method for conditioning a diaphragm of a patient
US20050043644A1 (en) * 2003-08-18 2005-02-24 Stahmann Jeffrey E. Prediction of disordered breathing
US20050043772A1 (en) * 2003-08-18 2005-02-24 Stahmann Jeffrey E. Therapy triggered by prediction of disordered breathing
US20050039745A1 (en) * 2003-08-18 2005-02-24 Stahmann Jeffrey E. Adaptive therapy for disordered breathing
US20050115561A1 (en) * 2003-08-18 2005-06-02 Stahmann Jeffrey E. Patient monitoring, diagnosis, and/or therapy systems and methods
US20050101833A1 (en) * 2003-09-02 2005-05-12 Biotronik Gmbh & Co. Kg Apparatus for the treatment of sleep apnea
US20050055060A1 (en) * 2003-09-05 2005-03-10 Steve Koh Determination of respiratory characteristics from AV conduction intervals
US20050061320A1 (en) * 2003-09-18 2005-03-24 Cardiac Pacemakers, Inc. Coordinated use of respiratory and cardiac therapies for sleep disordered breathing
US20050061319A1 (en) * 2003-09-18 2005-03-24 Cardiac Pacemakers, Inc. Methods and systems for implantably monitoring external breathing therapy
US20050145246A1 (en) * 2003-09-18 2005-07-07 Hartley Jesse W. Posture detection system and method
US20050065567A1 (en) * 2003-09-18 2005-03-24 Cardiac Pacemakers, Inc. Therapy control based on cardiopulmonary status
US20050080461A1 (en) * 2003-09-18 2005-04-14 Stahmann Jeffrey E. System and method for moderating a therapy delivered during sleep using physiologic data acquired during non-sleep
US20050074741A1 (en) * 2003-09-18 2005-04-07 Kent Lee System and method for discrimination of central and obstructive disordered breathing events
US20050061315A1 (en) * 2003-09-18 2005-03-24 Kent Lee Feedback system and method for sleep disordered breathing therapy
US20050076909A1 (en) * 2003-09-18 2005-04-14 Stahmann Jeffrey E. Synergistic use of medical devices for detecting medical disorders
US20050065563A1 (en) * 2003-09-23 2005-03-24 Avram Scheiner Paced ventilation therapy by an implantable cardiac device
US20060142815A1 (en) * 2003-10-15 2006-06-29 Tehrani Amir J Device and method for treating obstructive sleep apnea
US20050085868A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. Breathing therapy device and method
US20060167523A1 (en) * 2003-10-15 2006-07-27 Tehrani Amir J Device and method for improving upper airway functionality
US20050085866A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. Breathing disorder and precursor predictor and therapy delivery device and method
US20060030894A1 (en) * 2003-10-15 2006-02-09 Tehrani Amir J Breathing disorder detection and therapy device for providing intrinsic breathing
US20060036294A1 (en) * 2003-10-15 2006-02-16 Tehrani Amir J Patient compliance management device and method
US20060149334A1 (en) * 2003-10-15 2006-07-06 Tehrani Amir J Device and method for controlling breathing
US20050085865A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. Breathing disorder detection and therapy delivery device and method
US20050085867A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. System and method for diaphragm stimulation
US20060155341A1 (en) * 2003-10-15 2006-07-13 Tehrani Amir J Device and method for biasing lung volume
US20050085869A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. System and method for mapping diaphragm electrode sites
US20070021795A1 (en) * 2003-10-15 2007-01-25 Inspiration Medical, Inc. Device and method for adding to breathing
US20050148897A1 (en) * 2003-12-24 2005-07-07 Cho Yong K. Implantable medical device with sleep disordered breathing monitoring
US20050165457A1 (en) * 2004-01-26 2005-07-28 Michael Benser Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration
US7070568B1 (en) * 2004-03-02 2006-07-04 Pacesetter, Inc. System and method for diagnosing and tracking congestive heart failure based on the periodicity of Cheyne-Stokes Respiration using an implantable medical device
US7082331B1 (en) * 2004-04-21 2006-07-25 Pacesetter, Inc. System and method for applying therapy during hyperpnea phase of periodic breathing using an implantable medical device
US20060058852A1 (en) * 2004-09-10 2006-03-16 Steve Koh Multi-variable feedback control of stimulation for inspiratory facilitation
US20060122622A1 (en) * 2004-12-06 2006-06-08 Csaba Truckai Bone treatment systems and methods

Cited By (169)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7206635B2 (en) * 2001-06-07 2007-04-17 Medtronic, Inc. Method and apparatus for modifying delivery of a therapy in response to onset of sleep
US20110060381A1 (en) * 2003-07-23 2011-03-10 Ignagni Anthony R System and Method for Conditioning a Diaphragm of a Patient
US8706236B2 (en) 2003-07-23 2014-04-22 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US8406885B2 (en) 2003-07-23 2013-03-26 Synapse Biomedical, Inc. System and method for conditioning a diaphragm of a patient
US8200336B2 (en) 2003-10-15 2012-06-12 Rmx, Llc System and method for diaphragm stimulation
US20060122662A1 (en) * 2003-10-15 2006-06-08 Tehrani Amir J Device and method for increasing functional residual capacity
US20060149334A1 (en) * 2003-10-15 2006-07-06 Tehrani Amir J Device and method for controlling breathing
US20060155341A1 (en) * 2003-10-15 2006-07-13 Tehrani Amir J Device and method for biasing lung volume
US8467876B2 (en) * 2003-10-15 2013-06-18 Rmx, Llc Breathing disorder detection and therapy delivery device and method
US20060247729A1 (en) * 2003-10-15 2006-11-02 Tehrani Amir J Multimode device and method for controlling breathing
US7970475B2 (en) 2003-10-15 2011-06-28 Rmx, Llc Device and method for biasing lung volume
US20070021795A1 (en) * 2003-10-15 2007-01-25 Inspiration Medical, Inc. Device and method for adding to breathing
US9259573B2 (en) 2003-10-15 2016-02-16 Rmx, Llc Device and method for manipulating exhalation
US7979128B2 (en) 2003-10-15 2011-07-12 Rmx, Llc Device and method for gradually controlling breathing
US8412331B2 (en) 2003-10-15 2013-04-02 Rmx, Llc Breathing therapy device and method
US9370657B2 (en) 2003-10-15 2016-06-21 Rmx, Llc Device for manipulating tidal volume and breathing entrainment
US8509901B2 (en) 2003-10-15 2013-08-13 Rmx, Llc Device and method for adding to breathing
US20060036294A1 (en) * 2003-10-15 2006-02-16 Tehrani Amir J Patient compliance management device and method
US8255056B2 (en) 2003-10-15 2012-08-28 Rmx, Llc Breathing disorder and precursor predictor and therapy delivery device and method
US20060030894A1 (en) * 2003-10-15 2006-02-09 Tehrani Amir J Breathing disorder detection and therapy device for providing intrinsic breathing
US8348941B2 (en) 2003-10-15 2013-01-08 Rmx, Llc Demand-based system for treating breathing disorders
US20050085867A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. System and method for diaphragm stimulation
US20080188904A1 (en) * 2003-10-15 2008-08-07 Tehrani Amir J Device and method for treating disorders of the cardiovascular system or heart
US8335567B2 (en) 2003-10-15 2012-12-18 Rmx, Llc Multimode device and method for controlling breathing
US8265759B2 (en) 2003-10-15 2012-09-11 Rmx, Llc Device and method for treating disorders of the cardiovascular system or heart
US20050085869A1 (en) * 2003-10-15 2005-04-21 Tehrani Amir J. System and method for mapping diaphragm electrode sites
US20080167695A1 (en) * 2003-10-15 2008-07-10 Tehrani Amir J Therapeutic diaphragm stimulation device and method
US20110230932A1 (en) * 2003-10-15 2011-09-22 Rmx, Llc Device and method for independently stimulating hemidiaphragms
US8244358B2 (en) 2003-10-15 2012-08-14 Rmx, Llc Device and method for treating obstructive sleep apnea
US8140164B2 (en) 2003-10-15 2012-03-20 Rmx, Llc Therapeutic diaphragm stimulation device and method
US20080208281A1 (en) * 2003-10-15 2008-08-28 Tehrani Amir J Device and method for biasing and stimulating respiration
US8116872B2 (en) 2003-10-15 2012-02-14 Rmx, Llc Device and method for biasing and stimulating respiration
US8160711B2 (en) 2003-10-15 2012-04-17 Rmx, Llc Multimode device and method for controlling breathing
US20080269625A1 (en) * 2004-02-05 2008-10-30 Earlysense Ltd. Prediction and monitoring of clinical episodes
US8992434B2 (en) 2004-02-05 2015-03-31 Earlysense Ltd. Prediction and monitoring of clinical episodes
US8840564B2 (en) 2004-02-05 2014-09-23 Early Sense Ltd. Monitoring a condition of a subject
US8942779B2 (en) 2004-02-05 2015-01-27 Early Sense Ltd. Monitoring a condition of a subject
US8731646B2 (en) 2004-02-05 2014-05-20 Earlysense Ltd. Prediction and monitoring of clinical episodes
US8403865B2 (en) 2004-02-05 2013-03-26 Earlysense Ltd. Prediction and monitoring of clinical episodes
US8679030B2 (en) 2004-02-05 2014-03-25 Earlysense Ltd. Monitoring a condition of a subject
US8603010B2 (en) 2004-02-05 2013-12-10 Earlysense Ltd. Techniques for prediction and monitoring of clinical episodes
US8517953B2 (en) 2004-02-05 2013-08-27 Earlysense Ltd. Techniques for prediction and monitoring of coughing-manifested clinical episodes
US9131902B2 (en) 2004-02-05 2015-09-15 Earlysense Ltd. Prediction and monitoring of clinical episodes
US8491492B2 (en) 2004-02-05 2013-07-23 Earlysense Ltd. Monitoring a condition of a subject
US8376954B2 (en) 2004-02-05 2013-02-19 Earlysense Ltd. Techniques for prediction and monitoring of respiration-manifested clinical episodes
US20070265611A1 (en) * 2004-07-23 2007-11-15 Ignagni Anthony R Ventilatory assist system and methods to improve respiratory function
US7962215B2 (en) 2004-07-23 2011-06-14 Synapse Biomedical, Inc. Ventilatory assist system and methods to improve respiratory function
US7869877B2 (en) 2004-08-09 2011-01-11 Cardiac Pacemakers, Inc. Cardiopulmonary functional status assessment via heart rate response detection by implantable cardiac device
US20080004668A1 (en) * 2004-08-09 2008-01-03 Cardiac Pacemakers, Inc. Cardiopulmonary functional status assessment via heart rate response dectection by implantable cardiac device
US8538525B2 (en) 2004-08-12 2013-09-17 Cardiac Pacemakers, Inc. Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device
US8903491B2 (en) 2004-08-12 2014-12-02 Cardiac Pacemakers, Inc. Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device
US20060101871A1 (en) * 2004-11-12 2006-05-18 Matsushita Electric Industrial Co., Ltd. Drum type washing and drying machine
US7704211B1 (en) * 2005-03-21 2010-04-27 Pacesetter, Inc. Method and apparatus for assessing fluid level in lungs
US8014860B2 (en) 2005-04-20 2011-09-06 Cardiac Pacemakers, Inc. Thoracic or intracardiac impedance detection with automatic vector selection
US8761876B2 (en) 2005-04-20 2014-06-24 Cardiac Pacemakers, Inc. Thoracic or intracardiac impedance detection with automatic vector selection
US20100056884A1 (en) * 2005-04-20 2010-03-04 Jonathan Kwok Thoracic or intracardiac impedance detection with automatic vector selection
US7630763B2 (en) 2005-04-20 2009-12-08 Cardiac Pacemakers, Inc. Thoracic or intracardiac impedance detection with automatic vector selection
US8473050B2 (en) 2005-04-20 2013-06-25 Cardiac Pacemakers, Inc. Thoracic or intracardiac impedance detection with automatic vector selection
US20060241512A1 (en) * 2005-04-20 2006-10-26 Cardiac Pacemakers, Inc. Thoracic or intracardiac impedance detection with automatic vector selection
US8295927B2 (en) 2005-05-25 2012-10-23 Cardiac Pacemakers, Inc. Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
US8126548B2 (en) 2005-05-25 2012-02-28 Cardiac Pacemakers, Inc. Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
US20080114410A1 (en) * 2005-05-25 2008-05-15 Cardiac Pacemakers, Inc. Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
US20070021678A1 (en) * 2005-07-19 2007-01-25 Cardiac Pacemakers, Inc. Methods and apparatus for monitoring physiological responses to steady state activity
US9839781B2 (en) 2005-08-22 2017-12-12 Cardiac Pacemakers, Inc. Intracardiac impedance and its applications
US8494618B2 (en) * 2005-08-22 2013-07-23 Cardiac Pacemakers, Inc. Intracardiac impedance and its applications
US20070043394A1 (en) * 2005-08-22 2007-02-22 Cardiac Pacemakers, Inc Intracardiac impedance and its applications
US20070044669A1 (en) * 2005-08-24 2007-03-01 Geise Gregory D Aluminum can compacting mechanism with improved actuation handle assembly
US20070049793A1 (en) * 2005-08-25 2007-03-01 Ignagni Anthony R Method And Apparatus For Transgastric Neurostimulation
US9050005B2 (en) 2005-08-25 2015-06-09 Synapse Biomedical, Inc. Method and apparatus for transgastric neurostimulation
US20100228133A1 (en) * 2005-09-16 2010-09-09 Averina Viktoria A System and Method for Generating a Trend Parameter Based on Respiration Rate Distribution
US8372012B2 (en) 2005-09-16 2013-02-12 Cardiac Pacemakers, Inc. System and method for generating a trend parameter based on respiration rate distribution
US20070066905A1 (en) * 2005-09-21 2007-03-22 Cardiac Pacemakers, Inc. Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance
US7974691B2 (en) 2005-09-21 2011-07-05 Cardiac Pacemakers, Inc. Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance
US8712521B2 (en) 2005-09-21 2014-04-29 Cardiac Pacemakers, Inc. Method and apparatus for controlling cardiac resynchronization therapy using cardiac impedance
US9026199B2 (en) 2005-11-01 2015-05-05 Earlysense Ltd. Monitoring a condition of a subject
US20070118054A1 (en) * 2005-11-01 2007-05-24 Earlysense Ltd. Methods and systems for monitoring patients for clinical episodes
US20070118183A1 (en) * 2005-11-18 2007-05-24 Mark Gelfand System and method to modulate phrenic nerve to prevent sleep apnea
US8244359B2 (en) 2005-11-18 2012-08-14 Respicardia, Inc. System and method to modulate phrenic nerve to prevent sleep apnea
US20070150023A1 (en) * 2005-12-02 2007-06-28 Ignagni Anthony R Transvisceral neurostimulation mapping device and method
US8676323B2 (en) 2006-03-09 2014-03-18 Synapse Biomedical, Inc. Ventilatory assist system and methods to improve respiratory function
US20080125828A1 (en) * 2006-03-09 2008-05-29 Ignagni Anthony R Ventilatory assist system and methods to improve respiratory function
US20080109047A1 (en) * 2006-10-26 2008-05-08 Pless Benjamin D Apnea treatment device
US7917194B1 (en) * 2006-11-15 2011-03-29 Pacesetter, Inc. Method and apparatus for detecting pulmonary edema
US8280513B2 (en) 2006-12-22 2012-10-02 Rmx, Llc Device and method to treat flow limitations
US20080154330A1 (en) * 2006-12-22 2008-06-26 Tehrani Amir J Device and method to treat flow limitations
US8909341B2 (en) 2007-01-22 2014-12-09 Respicardia, Inc. Device and method for the treatment of breathing disorders and cardiac disorders
US9744351B1 (en) 2007-01-22 2017-08-29 Respicardia, Inc. Device and method for the treatment of breathing disorders and cardiac disorders
US20080208282A1 (en) * 2007-01-22 2008-08-28 Mark Gelfand Device and method for the treatment of breathing disorders and cardiac disorders
US9079016B2 (en) 2007-02-05 2015-07-14 Synapse Biomedical, Inc. Removable intramuscular electrode
US20080188867A1 (en) * 2007-02-05 2008-08-07 Ignagni Anthony R Removable intramuscular electrode
US20080234556A1 (en) * 2007-03-20 2008-09-25 Cardiac Pacemakers, Inc. Method and apparatus for sensing respiratory activities using sensor in lymphatic system
US8734360B2 (en) 2007-05-02 2014-05-27 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8585607B2 (en) 2007-05-02 2013-11-19 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8821418B2 (en) 2007-05-02 2014-09-02 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US9820671B2 (en) 2007-05-17 2017-11-21 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US20080287820A1 (en) * 2007-05-17 2008-11-20 Synapse Biomedical, Inc. Devices and methods for assessing motor point electromyogram as a biomarker
US20100160992A1 (en) * 2007-05-28 2010-06-24 St. Jude Medical Ab Implantable medical device, system and method
US8914113B2 (en) 2007-08-28 2014-12-16 Cardiac Pacemakers, Inc. Method and apparatus for inspiratory muscle stimulation using implantable device
US20090062882A1 (en) * 2007-08-28 2009-03-05 Cardiac Pacemakers, Inc. Method and apparatus for inspiratory muscle stimulation using implantable device
US8135471B2 (en) 2007-08-28 2012-03-13 Cardiac Pacemakers, Inc. Method and apparatus for inspiratory muscle stimulation using implantable device
US20150005590A1 (en) * 2007-09-14 2015-01-01 Corventis, Inc. Multi-sensor patient monitor to detect impending cardiac decompensation
US9186089B2 (en) 2007-09-14 2015-11-17 Medtronic Monitoring, Inc. Injectable physiological monitoring system
US8897868B2 (en) 2007-09-14 2014-11-25 Medtronic, Inc. Medical device automatic start-up upon contact to patient tissue
US8460189B2 (en) 2007-09-14 2013-06-11 Corventis, Inc. Adherent cardiac monitor with advanced sensing capabilities
US9125566B2 (en) * 2007-09-14 2015-09-08 Medtronic Monitoring, Inc. Multi-sensor patient monitor to detect impending cardiac decompensation
US8374688B2 (en) 2007-09-14 2013-02-12 Corventis, Inc. System and methods for wireless body fluid monitoring
US9320443B2 (en) * 2007-09-14 2016-04-26 Medtronic Monitoring, Inc. Multi-sensor patient monitor to detect impending cardiac decompensation
US8591430B2 (en) 2007-09-14 2013-11-26 Corventis, Inc. Adherent device for respiratory monitoring
US9411936B2 (en) 2007-09-14 2016-08-09 Medtronic Monitoring, Inc. Dynamic pairing of patients to data collection gateways
US9770182B2 (en) 2007-09-14 2017-09-26 Medtronic Monitoring, Inc. Adherent device with multiple physiological sensors
US8790257B2 (en) 2007-09-14 2014-07-29 Corventis, Inc. Multi-sensor patient monitor to detect impending cardiac decompensation
US9538960B2 (en) 2007-09-14 2017-01-10 Medtronic Monitoring, Inc. Injectable physiological monitoring system
US8684925B2 (en) 2007-09-14 2014-04-01 Corventis, Inc. Injectable device for physiological monitoring
US8249686B2 (en) 2007-09-14 2012-08-21 Corventis, Inc. Adherent device for sleep disordered breathing
US8285356B2 (en) 2007-09-14 2012-10-09 Corventis, Inc. Adherent device with multiple physiological sensors
US9579020B2 (en) 2007-09-14 2017-02-28 Medtronic Monitoring, Inc. Adherent cardiac monitor with advanced sensing capabilities
US8116841B2 (en) 2007-09-14 2012-02-14 Corventis, Inc. Adherent device with multiple physiological sensors
US20090099621A1 (en) * 2007-10-10 2009-04-16 Zheng Lin Respiratory stimulation for treating periodic breathing
US8838245B2 (en) 2007-10-10 2014-09-16 Cardiac Pacemakers, Inc. Respiratory stimulation for treating periodic breathing
US8428711B2 (en) 2007-10-10 2013-04-23 Cardiac Pacemakers, Inc. Respiratory stimulation for treating periodic breathing
US8428726B2 (en) 2007-10-30 2013-04-23 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US20090118785A1 (en) * 2007-10-30 2009-05-07 Ignagni Anthony R Method of improving sleep disordered breathing
US8478412B2 (en) 2007-10-30 2013-07-02 Synapse Biomedical, Inc. Method of improving sleep disordered breathing
US9138580B2 (en) 2007-10-30 2015-09-22 Synapse Biomedical, Inc. Device and method of neuromodulation to effect a functionally restorative adaption of the neuromuscular system
US20090192394A1 (en) * 2008-01-16 2009-07-30 Guttag John V Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal
US8868163B2 (en) 2008-01-16 2014-10-21 Massachusetts Institute Of Technology Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal
US8346349B2 (en) * 2008-01-16 2013-01-01 Massachusetts Institute Of Technology Method and apparatus for predicting patient outcomes from a physiological segmentable patient signal
US9295846B2 (en) 2008-02-07 2016-03-29 Respicardia, Inc. Muscle and nerve stimulation
US8433412B1 (en) 2008-02-07 2013-04-30 Respicardia, Inc. Muscle and nerve stimulation
US8718752B2 (en) 2008-03-12 2014-05-06 Corventis, Inc. Heart failure decompensation prediction based on cardiac rhythm
US20140330091A1 (en) * 2008-03-12 2014-11-06 Corventis, Inc. Heart failure decompensation prediction based on cardiac rhythm
JP2011514831A (en) * 2008-03-12 2011-05-12 コーヴェンティス,インク.Corventis,Inc. Heart decompensation prediction based on heart rhythm
WO2009114548A1 (en) * 2008-03-12 2009-09-17 Corventis, Inc. Heart failure decompensation prediction based on cardiac rhythm
US20110054279A1 (en) * 2008-03-27 2011-03-03 Widemed Ltd. Diagnosis of periodic breathing
US8412317B2 (en) 2008-04-18 2013-04-02 Corventis, Inc. Method and apparatus to measure bioelectric impedance of patient tissue
US9883809B2 (en) 2008-05-01 2018-02-06 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8882684B2 (en) 2008-05-12 2014-11-11 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US8998830B2 (en) 2008-05-12 2015-04-07 Earlysense Ltd. Monitoring, predicting and treating clinical episodes
US20100016748A1 (en) * 2008-07-17 2010-01-21 Syed Zeeshan H Motif Discovery in Physiological Datasets: A Methodology for Inferring Predictive Elements
US8340746B2 (en) 2008-07-17 2012-12-25 Massachusetts Institute Of Technology Motif discovery in physiological datasets: a methodology for inferring predictive elements
US8231536B2 (en) 2008-09-19 2012-07-31 Medtronic, Inc. Method and apparatus for detecting respiratory effort in a medical device
US20100076325A1 (en) * 2008-09-19 2010-03-25 Cho Yong K Method and apparatus for determining respiratory effort in a medical device
US8372013B2 (en) 2008-09-19 2013-02-12 Medtronic, Inc. Method and apparatus for determining a respiration parameter in a medical device
US20100076324A1 (en) * 2008-09-19 2010-03-25 Cho Yong K Method and apparatus for detecting respiratory effort in a medical device
US8047999B2 (en) 2008-09-19 2011-11-01 Medtronic, Inc. Filtering of a physiologic signal in a medical device
US8202223B2 (en) 2008-09-19 2012-06-19 Medtronic, Inc. Method and apparatus for determining respiratory effort in a medical device
US9445719B2 (en) 2008-12-15 2016-09-20 Medtronic Monitoring, Inc. Patient monitoring systems and methods
US8823490B2 (en) 2008-12-15 2014-09-02 Corventis, Inc. Patient monitoring systems and methods
US8233987B2 (en) 2009-09-10 2012-07-31 Respicardia, Inc. Respiratory rectification
US20110060380A1 (en) * 2009-09-10 2011-03-10 Mark Gelfand Respiratory rectification
US8790259B2 (en) 2009-10-22 2014-07-29 Corventis, Inc. Method and apparatus for remote detection and monitoring of functional chronotropic incompetence
US9615757B2 (en) 2009-10-22 2017-04-11 Medtronic Monitoring, Inc. Method and apparatus for remote detection and monitoring of functional chronotropic incompetence
US9451897B2 (en) 2009-12-14 2016-09-27 Medtronic Monitoring, Inc. Body adherent patch with electronics for physiologic monitoring
US9173615B2 (en) 2010-04-05 2015-11-03 Medtronic Monitoring, Inc. Method and apparatus for personalized physiologic parameters
US8965498B2 (en) 2010-04-05 2015-02-24 Corventis, Inc. Method and apparatus for personalized physiologic parameters
US8585604B2 (en) 2010-10-29 2013-11-19 Medtronic, Inc. Integrated patient care
US20120157799A1 (en) * 2010-12-20 2012-06-21 Abhilash Patangay Using device based sensors to classify events and generate alerts
US9861817B2 (en) 2011-07-28 2018-01-09 Medtronic, Inc. Medical device to provide breathing therapy
US8509902B2 (en) 2011-07-28 2013-08-13 Medtronic, Inc. Medical device to provide breathing therapy
US20130197385A1 (en) * 2012-01-31 2013-08-01 Medtronic, Inc. Respiratory function detection
US20140031643A1 (en) * 2012-07-27 2014-01-30 Cardiac Pacemakers, Inc. Heart failure patients stratification
US20170112409A1 (en) * 2013-02-06 2017-04-27 BTS S.p.A. Wireless probe for dental electromyography
US9295397B2 (en) 2013-06-14 2016-03-29 Massachusetts Institute Of Technology Method and apparatus for beat-space frequency domain prediction of cardiovascular death after acute coronary event
US9743889B2 (en) 2013-08-05 2017-08-29 Cardiac Pacemakers, Inc. System and method for detecting worsening of heart failure based on rapid shallow breathing index
US9392950B2 (en) * 2013-08-20 2016-07-19 Sorin Crm Sas Systems and methods for diagnosing heart failure based on sleep apneic indicators
US20150057555A1 (en) * 2013-08-20 2015-02-26 Sorin Crm Sas Systems and methods for diagnosing heart failure based on sleep apneic indicators
CN103800999A (en) * 2014-02-25 2014-05-21 郑州雅晨生物科技有限公司 Obstructive sleep apnea hypopnea syndrome therapeutic apparatus
WO2016013684A1 (en) * 2014-07-22 2016-01-28 帝人ファーマ株式会社 Heart failure evaluation method and diagnosis device
JPWO2016013684A1 (en) * 2014-07-22 2017-04-27 帝人ファーマ株式会社 Evaluation method and diagnostic apparatus of heart failure

Also Published As

Publication number Publication date Type
WO2005037220A2 (en) 2005-04-28 application
WO2005037172A3 (en) 2005-08-04 application
DE112004001954B4 (en) 2015-10-22 grant
US8348941B2 (en) 2013-01-08 grant
US20130296964A1 (en) 2013-11-07 application
US8467876B2 (en) 2013-06-18 grant
WO2005037172A2 (en) 2005-04-28 application
US20070021795A1 (en) 2007-01-25 application
US20080188903A1 (en) 2008-08-07 application
WO2005037366A1 (en) 2005-04-28 application
WO2005037077A2 (en) 2005-04-28 application
US8509901B2 (en) 2013-08-13 grant
US20060036294A1 (en) 2006-02-16 application
US20050085867A1 (en) 2005-04-21 application
US20080208281A1 (en) 2008-08-28 application
WO2005037174A2 (en) 2005-04-28 application
US20050085869A1 (en) 2005-04-21 application
US20080183240A1 (en) 2008-07-31 application
DE112004001957T5 (en) 2006-08-31 application
WO2005037173A2 (en) 2005-04-28 application
US20050085865A1 (en) 2005-04-21 application
US8200336B2 (en) 2012-06-12 grant
US8412331B2 (en) 2013-04-02 grant
WO2005037174A3 (en) 2005-06-09 application
US8116872B2 (en) 2012-02-14 grant
WO2005037220A3 (en) 2005-07-07 application
US8255056B2 (en) 2012-08-28 grant
DE112004001954T5 (en) 2006-10-26 application
US20050085868A1 (en) 2005-04-21 application
US20130296973A1 (en) 2013-11-07 application
US20080183239A1 (en) 2008-07-31 application
US20060030894A1 (en) 2006-02-09 application
WO2005037077A3 (en) 2005-09-09 application
US20050085866A1 (en) 2005-04-21 application
WO2005037173A3 (en) 2005-06-30 application
DE112004001953T5 (en) 2006-10-26 application

Similar Documents

Publication Publication Date Title
US6280409B1 (en) Medical for tracking patient functional status
US7660632B2 (en) Method and apparatus for hypoglossal nerve stimulation
US20060271116A1 (en) Prediction of thoracic fluid accumulation
US7020521B1 (en) Methods and apparatus for detecting and/or monitoring heart failure
US20060089856A1 (en) Integrated pharmaceutical dispensing and patient management monitoring
US7167743B2 (en) Collecting activity information to evaluate therapy
US20060064136A1 (en) Method and apparatus for facilitating patient alert in implantable medical devices
US20130158616A1 (en) Implantable Device For Evaluating Autonomic Cardiovascular Drive In A Patient Suffering From Chronic Cardiac Dysfunction
US20060017575A1 (en) Alert system and method for an implantable medical device
US20060293609A1 (en) Sensitivity and specificity of pulmonary edema detection when using transthoracic impedance
US20040073128A1 (en) Detection of congestion from monitoring patient response to a recumbent position
US20060258952A1 (en) Enhancements to the detection of pulmonary edema when using transthoracic impedance
US20070123758A1 (en) Determination of sleep quality for neurological disorders
US20050137480A1 (en) Remote control of implantable device through medical implant communication service band
US20110282416A1 (en) Systems for patient control of implantable medical device therapy
US20050090871A1 (en) Implantable medical device and method for delivering therapy for sleep-disordered breathing
US20070032733A1 (en) Method and apparatus for ECG-derived sleep disordered breathing monitoring, detection and classification
US20070060797A1 (en) Automatic parameter status on an implantable medical device system
US20060265025A1 (en) Automatic lead functionality testing
US7610094B2 (en) Synergistic use of medical devices for detecting medical disorders
US7717848B2 (en) Collecting sleep quality information via a medical device
US20090275848A1 (en) Cardiac Risk Assessment
US20130158618A1 (en) Computer-Implemented System And Method For Selecting Therapy Profiles Of Electrical Stimulation Of Cervical Vagus Nerves For Treatment Of Chronic Cardiac Dysfunction
US8021299B2 (en) Correlating a non-polysomnographic physiological parameter set with sleep states
US7468040B2 (en) Methods and systems for implantably monitoring external breathing therapy

Legal Events

Date Code Title Description
AS Assignment

Owner name: INSPIRATION MEDICAL, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:TEHRANI, AMIR J.;REEL/FRAME:015749/0058

Effective date: 20050110

AS Assignment

Owner name: RMX, L.L.C., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:INSPIRATION MEDICAL, INC.;REEL/FRAME:020266/0533

Effective date: 20070831