US20040167434A1 - Dual Action Aspiration Biopsy Needle - Google Patents
Dual Action Aspiration Biopsy Needle Download PDFInfo
- Publication number
- US20040167434A1 US20040167434A1 US10/708,711 US70871104A US2004167434A1 US 20040167434 A1 US20040167434 A1 US 20040167434A1 US 70871104 A US70871104 A US 70871104A US 2004167434 A1 US2004167434 A1 US 2004167434A1
- Authority
- US
- United States
- Prior art keywords
- needle
- sharp edge
- slot
- tissue
- proximal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000001574 biopsy Methods 0.000 title claims abstract description 62
- 230000009977 dual effect Effects 0.000 title abstract description 3
- 230000033001 locomotion Effects 0.000 claims abstract description 9
- 239000000463 material Substances 0.000 claims description 37
- 238000003780 insertion Methods 0.000 claims description 7
- 230000037431 insertion Effects 0.000 claims description 7
- 238000010276 construction Methods 0.000 claims description 5
- 230000001413 cellular effect Effects 0.000 abstract description 40
- 230000003902 lesion Effects 0.000 abstract description 40
- 210000001519 tissue Anatomy 0.000 description 34
- 238000000034 method Methods 0.000 description 15
- 206010028980 Neoplasm Diseases 0.000 description 8
- 230000009471 action Effects 0.000 description 7
- 238000007790 scraping Methods 0.000 description 7
- 230000006872 improvement Effects 0.000 description 5
- 210000000481 breast Anatomy 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 235000013351 cheese Nutrition 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 201000003144 pneumothorax Diseases 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 210000000941 bile Anatomy 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000004224 pleura Anatomy 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000008733 trauma Effects 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000000834 fixative Substances 0.000 description 1
- 229920005570 flexible polymer Polymers 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 238000013188 needle biopsy Methods 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
- A61B10/0275—Pointed or sharp biopsy instruments means for severing sample with sample notch, e.g. on the side of inner stylet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/0233—Pointed or sharp biopsy instruments
- A61B10/0283—Pointed or sharp biopsy instruments with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/02—Instruments for taking cell samples or for biopsy
- A61B10/04—Endoscopic instruments
Definitions
- This invention relates, generally, to aspiration biopsy needles. More particularly, it relates to an aspiration biopsy needle having an enhanced cellular material collection capability.
- biopsy procedures There are three main types of biopsy procedures.
- a first type a conventional surgical incision is made and the patient's body is opened so that a surgeon may retrieve one or more large pieces of the tumor or lesion to be tested for malignancy.
- This type of biopsy is very invasive, expensive to perform, and requires a considerable recovery time.
- Inventive endeavors in the field have resulted in two improved procedures that substantially reduce the invasiveness of the biopsy procedure, as well as the expense of the procedure and the length of the recovery time.
- the first improved procedure involves the cutting or shearing of one or more visible pieces of the tumor or lesion by a relatively large bore needle.
- This type of biopsy is known as a core tissue biopsy and is performed with a core tissue biopsy needle.
- the pieces of tissue are usually about one to three millimeters in length and are thus visible to the unaided eye. They cannot be immediately examined under a microscope because they are too thick for light to pass therethrough. Accordingly, they must first be sliced into a plurality of very thin slices by a tissue-slicing machine. After slicing, they are then stained with a tissue fixative e.g., formalin, glutaraldehyde, etc., and placed upon a microscope slide for diagnostic purposes.
- a tissue fixative e.g., formalin, glutaraldehyde, etc.
- the fixed tissue is sliced into thin sections approximately eight (8) microns thick, the tissue sections are mounted on and cell-selective histiological stains are applied to stain the tissue prior to microscopic examination.
- This non-frozen tissue preparation technique typically requires twenty four to forty eight (24-48) hours to complete so the pathologist's diagnosis of the breast lesion may not be available until twenty four to seventy two (24-72) hours after the biopsy specimen was removed from the breast. Accordingly, histopathological examination and diagnosis of breast lesions may be much more time-consuming than the histopathological examination and diagnosis of other types of lesions.
- core tissue biopsy needle thus represents a significant improvement over the more invasive surgical removal of tumor or lesion specimens.
- the need to slice the specimens causes a delay in providing the diagnosis, due to processing.
- the diameter of core biopsy needles are typically larger than the diameter of fine needle aspiration (FNA) needles, thereby increasing the risk of procedure-related complications including bleeding, pneumothorax, and bile leakage.
- FNA fine needle aspiration
- the use of core biopsy needles necessitates the purchase and maintenance of tissue slicing machines. The material must be removed from the needle, deposited onto the machine, machine-sliced, removed from the machine after slicing, stained, and deposited onto a microscope slide.
- FIG. 1 One example of a core tissue biopsy needle is disclosed in U.S. Pat. No. 5,320,110 to Wang.
- the Wang structure has utility in performing a pleural tissue biopsy by cutting tissue samples of the parietal pleura.
- Wang teaches a two needle (tube-in-tube) system having a sharp edge to fix tissue while a second needle is advanced to shear off a piece of the tissue.
- the device does not rely solely on a vacuum to draw in material as in an FNA biopsy needle and tissue is sheared off in sizeable, visible pieces, i.e., not at the cellular level.
- the Wang device a hook engages the pleural tissue and an outer cannula is advanced to cut off the hooked piece of pleural tissue.
- This two needle system is designed to reduce the chances of a pneumothorax and thus represents a significant improvement over earlier biopsy techniques.
- the diameter of the Wang needle as described is about 4.5 mm, which is considerably larger than an FNA biopsy needle of the novel type disclosed herein which is typically no larger than 20-22 gauge.
- the Wang needle is not designed as a fine needle aspiration device but is designed to cut off pieces of lung pleura.
- a large diameter needle like the Wang device measuring about 4.5 mm in diameter is inappropriate for fine needle biopsy procedures due to the high risk of complications from a large tissue puncture including bleeding, pneumothorax and bile leakage.
- the Wang structure includes a notch formed in a first side of the large bore needle and a hole in an opposite side thereof.
- the tissue to be cut extends into the notch and is sliced off when the outer needle or cannula is advanced as aforesaid.
- No such opposing hole can be provided in an FNA biopsy needle because such hole would allow the escape of cellular material when it is deposited directly from the syringe barrel onto a microscope slide in which the distal tip bevel and side notch must point in the same direction.
- the distal tip of the Wang outer needle is not hollow and therefore no tissue cutting occurs at said distal tip. All tissue cutting occurs at the side of the Wang needle where the notch is positioned.
- the Wang needle collects relatively large samples in a knifing action, and performs no scraping action capable of collecting samples at the cellular level.
- Wang nor any other known two needle systems include both an open distal end and a port for cutting tissue nor is any core biopsy system capable of collecting samples of cellular thickness. It should also be observed that the Wang needle is attached to a syringe barrel and includes a pressure flap.
- biopsy tools that collect large specimens include spring-loaded core biopsy guns.
- An example of a vacuum-assisted biopsy device is the Mammotome Biopsys® breast biopsy device.
- the third technique is called fine needle aspiration (FNA) biopsy and is performed with an FNA biopsy needle.
- An FNA biopsy needle scrapes cells from the tumor or lesion that are so small as to be invisible to the unaided eye.
- the cellular material is already very thin when it is collected so there is no need to slice it to a thinner size prior to viewing it on a microscope slide because light can already pass through the thin cell layer.
- the cellular material is deposited onto a microscope slide directly from the FNA biopsy needle, stained, and viewed so that there is less time to the final biopsy report because the slicing machine and all of the handling steps necessitated thereby are eliminated. Trauma to the patient is greatly reduced because of smaller needle diameter and because cells are scraped instead of tissue being cut in thick pieces. Complication risk is also minimized or eliminated due to smaller nozzle diameters.
- FNA biopsy needles collect samples by aspiration; a vacuum applied to the proximal end of a hollow needle pulls severed cellular material from the lesion into the lumen of the needle. The needle is then retracted from the soft tissue so that the cellular material in the lumen can be removed for analysis. If more samples of the lesion are needed, the biopsy needle is reintroduced into the lesion.
- FNA biopsy needle The primary distinction between an FNA biopsy needle and a core tissue biopsy needle is that the latter cuts or slices relatively large pieces of tissue from a lesion or tumor whereas the former scrapes cellular material from a lesion or tumor.
- a core needle aspiration biopsy needle is like a knife that cuts slices of cheese and an FNA biopsy needle is like a cheese grater that scrapes small flakes of cheese.
- the FNA biopsy procedure fails to collect a sample of sufficient size to enable definitive pathological analysis. When that happens, the physician must repeat the procedure, causing additional trauma to the body part undergoing biopsy and creating an additional risk of an adverse event.
- FNA biopsy needles represent a significant improvement over more invasive procedures for performing biopsies on suspect lesions or tumors
- the novel aspiration biopsy needle includes a single needle of elongate, hollow construction having a proximal end and a beveled distal end.
- the beveled distal end of the needle is open and therefore forms a first sharp edge adapted to scrape cellular material when the needle is inserted into tissue.
- the needle is displaced from a proximal position to a distal position during insertion.
- the needle has a uniform diameter along a substantial part of its extent.
- a slot is formed in the needle near the beveled distal end; the slot is transversely disposed relative to a longitudinal axis of the needle.
- the slot is also angled relative to a transverse axis of the needle such that a bottom of the slot is positioned distal to an opening of the slot.
- the opening of the slot includes a second sharp edge adapted to scrape tissue of cellular size when the needle is displaced from a distal position to a proximal position.
- the novel structure further includes conventional means for applying a vacuum to a proximal end of the needle so that cellular material removed by the first sharp edge during proximal-to-distal travel of the needle is pulled into a lumen of the needle and so that cellular material removed by the second sharp edge during distal-to-proximal travel of the needle is also pulled into the lumen.
- the novel structure also has utility when no vacuum means is employed, i.e., even if it is not affixed to a syringe barrel.
- the cellular material is deposited from the lumen of the single FNA needle onto a slide for microscopic inspection in the absence of any need to slice said cellular material and to place said cellular material, following staining, into a formative to preserve the tissue.
- the slot has a circumferential extent of about one half the circumference of the needle.
- the second sharp edge is coincident with the exterior surface of the needle.
- the second sharp edge is raised with respect to the exterior surface of said needle, and in a third embodiment, the sharp edge is recessed with respect to said exterior surface.
- the slot is also angled relative to a transverse axis of the needle such that a bottom of the slot is positioned proximal to an opening of the slot and the second sharp edge thereby created is coincident with the exterior surface if the needle.
- the second sharp edge of the fourth embodiment is elevated and recessed, respectively, relative to the exterior surface of the needle.
- a first slot is formed in the needle as in the first embodiment and a second slot is formed in the needle as in the fourth embodiment.
- the first and second slots are longitudinally spaced apart from one another.
- a transversely disposed channel is formed in the needle and provides a second and a third sharp edge that are coincident with the exterior surface of the needle.
- the second and third sharp edges, respectively, are elevated with respect to the exterior surface of the needle and in eleventh and twelfth embodiments, the second and third sharp edges, respectively, are recessed with respect to said exterior surface.
- the second sharp edge is mounted for pivotal movement about a transversely disposed hinge.
- the hinge enables the second sharp edge to open wider relative to its non-hinged position so that it may scrape off larger numbers of cellular material as the needle is displaced in a distal-to-proximal direction.
- the third sharp edge is mounted for pivotal movement about a transversely disposed hinge and in additional embodiments, both the second and third sharp edges are so mounted.
- a primary object of the invention is to provide a fine needle aspiration biopsy needle that collects a greater quantity of cellular material per needle insertion than conventional fine needle aspiration biopsy needles.
- a closely related object is to accomplish the foregoing object by making a structural change to an existing FNA biopsy needle so that physicians will have a sense of familiarity when employing the improved needle.
- a more specific object is to provide an FNA biopsy needle capable of collecting cellular material as the needle is reciprocated along its longitudinal axis at a tissue collection site.
- FIG. 1 is a perspective view of a first embodiment of the novel aspiration biopsy needle
- FIG. 2 is an enlarged perspective view of the distal end of the needle of said first embodiment
- FIG. 3 is an enlarged longitudinal sectional view of the parts depicted in FIG. 2;
- FIG. 4 is an enlarged perspective view of the distal end of a second embodiment
- FIG. 5 is an enlarged longitudinal sectional view of the parts depicted in FIG. 4;
- FIG. 6 in an enlarged longitudinal sectional view of a third embodiment
- FIG. 7 is an enlarged longitudinal sectional view of a fourth embodiment
- FIG. 8 is an enlarged longitudinal sectional view of a fifth embodiment
- FIG. 9 is an enlarged longitudinal sectional view of a sixth embodiment
- FIG. 10 is an enlarged longitudinal sectional view of a seventh embodiment
- FIG. 11 is an enlarged longitudinal sectional view of a eighth embodiment
- FIG. 12 is an enlarged sectional view of a ninth embodiment
- FIG. 13 is an enlarged sectional view of a tenth embodiment
- FIG. 14 is an enlarged sectional view of an eleventh embodiment
- FIG. 15 is an enlarged sectional view of a twelfth embodiment
- FIG. 16 is an enlarged sectional view of a thirteenth embodiment.
- FIG. 17 is a diagrammatic view of a fourteenth embodiment where the novel biopsy device is used with an endoscope.
- the reference numeral 10 denotes a first illustrative embodiment of the present invention.
- the proximal end 12 of aspiration biopsy needle 10 is mounted in a LUER LOK® adapter 13 or equivalent structure to which a vacuum is applied from a remote source of negative pressure, not shown, when the leading or distal end 14 of said needle is inserted into a suspect lesion in soft tissue.
- the sharp leading end 14 is beveled in a well-known way to form a first sharp edge that scrapes cellular material from the lesion as it travels therethrough in a proximal-to-distal direction.
- a vacuum applied to adapter 13 pulls cellular material severed from the lesion into lumen 16 of the needle.
- the well-known prior art procedure ends at this point, i.e., the needle having a sample of the lesion in its lumen is retracted from the soft tissue and the sample is delivered to a lab for analysis. Additional sample-taking requires additional insertions of the needle into the lesion.
- a first innovation of this invention includes slot 18 formed in needle 10 , near first sharp edge 14 thereof.
- Slot 18 is transversely disposed relative to a longitudinal axis of the needle.
- a lower end or bottom of the slot is distal to the open upper end thereof.
- a second sharp edge 20 is formed at the distal edge of the upper end of the slot. Accordingly second sharp edge 20 scrapes cellular material from a lesion when the needle is retracted, i.e., when the needle is displaced along its longitudinal axis in a distal-to-proximal direction.
- a physician may reciprocate needle 10 along its longitudinal axis, collecting cells of a suspect lesion that are scraped off by the first sharp edge 14 during the proximal-to-distal portion of each reciprocation, and collecting cellular aspirate of said lesion that are scraped by second sharp edge 20 during the distal-to-proximal portion of each reciprocation.
- the chances of collecting a quantity of lesion that is sufficient for analysis is greatly enhanced by the provision of second sharp edge 20 .
- slot 18 is approximately equal to half of the circumference of needle 10 , but that structural feature of slot 18 is not critical to this invention; the circumferential extent of said slot could be more or less than that described and depicted.
- second sharp edge 20 is coincident or flush with the exterior surface of needle 10 in this first embodiment.
- FIG. 4 provides a perspective view of a second embodiment of needle 10 where second sharp edge 20 a is elevated with respect to the exterior surface of needle 10 and FIG. 5 provides a longitudinal sectional view of said second embodiment.
- the protrusion of second sharp edge 20 a above the exterior surface of the needle ensures that the cellular material collected when using this second embodiment should be greater than the amount of cellular material collected when using the first embodiment.
- FIG. 6 provides a longitudinal sectional view of a third embodiment where second sharp edge 20 b is recessed with respect to said exterior surface.
- the lesion not shown, is under compression as needle 10 penetrates it. Accordingly, an amount of tissue will enter into slot 18 and be scraped off during distal-to-proximal travel of needle 10 , even though sharp edge 20 b is recessed with respect to the exterior surface of the needle.
- FIG. 7 depicts a fourth embodiment where a slot 18 a is formed transversely to the longitudinal axis of needle 10 as in the first embodiment, but the axis of symmetry of slot 18 a is normal to the axis of symmetry of slot 18 .
- the bottom of slot 18 a is proximal to the open upper end of slot 18 a .
- a third sharp edge denoted 20 c .
- Third sharp edge 20 c is auxiliary to first sharp edge 14 in that said third sharp edge scrapes cellular material from a lesion during proximal-to-distal travel of needle 10 .
- FIGS. 8 and 9 depict fifth and sixth embodiments, respectively, where third sharp edges 20 d and 20 e are elevated and recessed, respectively, with respect to the exterior surface of needle 10 .
- a seventh embodiment depicted in FIG. 10, includes first slot 18 of the first embodiment and second slot 18 a of the fourth embodiment.
- the respective axes of symmetry of said slots are normal to one another and said slots 18 and 18 a are longitudinally spaced apart from one another as depicted.
- second sharp edge 20 is elevated or recessed relative to the exterior surface of needle 10 , as is third sharp edge 20 c.
- FIG. 11 depicts an eighth embodiment.
- This embodiment like the seventh, provides two auxiliary sharp edges to augment beveled edge 14 . However, it provides a single transversely disposed channel as distinguished from two transversely disposed slots. Thus, instead of slot 18 , transversely disposed channel 21 is formed in said needle 10 .
- Channel 21 includes a pair of longitudinally spaced apart undercuts that respectively form second and third sharp edges 20 and 20 c .
- Second sharp edge 20 performs in the same way as second sharp edge 20 of the first embodiment, i.e., it functions during distal-to-proximal travel of needle 10 .
- Third sharp edge 20 c functions in the same way as third sharp edge 20 c of the fourth embodiment, i.e., during proximal-to-distal travel.
- first sharp edge 14 and third sharp edge 20 c function during proximal-to-distal travel, but the amount of cellular material scraped from the lesion during such sharp action may not be the same.
- This eighth embodiment is also similar to the seventh embodiment because second and third sharp edges 20 , 20 c are flush with the exterior surface of needle 10 .
- FIGS. 12 and 13 depict ninth and tenth embodiments, respectively, where second sharp edge 20 f and third sharp edge 20 g are elevated, respectively, with respect to the exterior surface of needle 10 .
- FIGS. 14 and 15 depict eleventh and twelfth embodiments, respectively, where second sharp edge 20 b and third sharp edge 20 e are recessed, respectively, with respect to the exterior surface of needle 10 .
- FIG. 16 provides a longitudinal sectional view where second sharp edge 20 is pivotally mounted by transversely disposed hinge means 22 so that second sharp edge 20 may open as indicated by arcuate directional arrow 24 to the position indicated in dotted lines to scrape larger numbers of cells from the suspect lesion during distal-to-proximal travel of the biopsy needle.
- Second sharp edge 20 is biased against outward rotation.
- bias means such as different types of springs could be employed but the preferred bias means is a living hinge formed of nitenol or other suitable material. The hinge is held in its closed, FIG. 16 position when the needle is traveling in a proximal-to-distal direction, i.e., as the needle is inserted, but opens due to frictional forces created by the lesion as depicted in dotted lines in FIG. 16 when the needle is retracted, i.e., when the needle is displaced in a distal-to-proximal direction.
- a control means not depicted, under the control of the physician, causes second sharp edge 20 to pivot about hinge means 22 in small incremental amounts so that the depth of the cellular aspirate taken from the lesion is controlled with precision.
- sharp edges 20 a , 20 b , 20 c , 20 d , 20 e , 20 f , and 20 g could also be provided in pivotal form and placed under the control of the control means.
- each sharp edge 20 , 20 a , 20 b , 20 c , 20 d , 20 e , 20 f , and 20 g may be enhanced by several differing means.
- empirical studies may show that the cell-scraping ability of said sharp edges is enhanced by making said sharp edges abrasive.
- Adhesive of the type that cellular material clings to could also be added to said sharp edge or edges.
- the cut that forms sharp edges 20 , 20 a , 20 b , and 20 f are disposed substantially parallel to the bevel cut that forms first sharp edge 14 of needle 10 . Accordingly, said sharp edges scrape tissue with the same degree of efficiency as first sharp edge 14 .
- the scraping action provided by these sharp edges is during the distal-to-proximal stroke of needle 10 whereas the scraping action provided by first sharp edge 14 is during the proximal-to-distal stroke.
- the cut that forms third sharp edges 20 c , 20 d , 20 e , and 20 g is substantially normal to the cut that forms second sharp edges 20 , 20 a , 20 b , and 20 f .
- the scraping action of said third sharp edges is during proximal-to-distal motion of the needle and as such said third sharp edges cut cellular material at the same time that first sharp edge 14 cuts cellular material.
- Needle 10 is used by inserting it into a lesion in a well-known way and by reciprocating it multiple times along its longitudinal axis.
- Each proximal-to-distal displacement causes first sharp edge 14 and third sharp edges 20 c , 20 d , 20 e , or 20 g , depending upon the embodiment used, to sever cells from the lesion and a vacuum pulls such cellular aspirate of the lesion into lumen 16 .
- Each distal-to-proximal motion causes second sharp edges 20 , 20 a , 20 b , or 20 f , depending upon the embodiment used, to scrape off parts of the lesion.
- novel aspiration biopsy needle 10 collects at least twice the amount of lesion material as would a conventional aspiration biopsy needle. The quantity of scraped-off lesion parts collected is increased with each subsequent reciprocation. In this way, a sufficient sample may be taken with a single needle insertion followed by multiple reciprocations.
- Additional quantities of lesion material may also be collected by rotating needle 10 about its longitudinal axis of symmetry after a first set of reciprocations has been made. Additional rotations may follow additional reciprocations, it being understood that each rotational adjustment exposes an unscraped mass of lesion until the needle has been through three hundred sixty degrees of rotation.
- FIG. 17 depicts how an endoscope or laparoscope 24 is used in connection with fine needle aspiration biopsy device 10 .
- the well-known attachments to the endoscope such as a light source, camera unit, monitor, and the like are not depicted to avoid cluttering the drawing.
- Syringe 26 is of conventional construction and is connected to an elongate, flexible polymer tube or a guide tube 28 of the hollow, coiled cable type. Tube wire 28 may be up to one hundred fifty centimeters (150 cm) in length and is inserted into the operating channel of the endoscope or laparoscope 24 as depicted.
- Novel fine aspiration biopsy device 10 is secured to the distal end of the tube or guide wire 28 .
Abstract
Description
- This disclosure is a divisional application claiming the benefit of the filing date of pending U.S. patent application entitled: “Dual Action Aspiration Biopsy Needle,” by the same inventor, filed on Sep. 23, 2002, bearing Ser. No. 10/065,155 which is a continuation-in-part of U.S. Pat. No. 6,592,608 that issued on Jul. 15, 2003 by the same inventor.
- 1. Field of the Invention
- This invention relates, generally, to aspiration biopsy needles. More particularly, it relates to an aspiration biopsy needle having an enhanced cellular material collection capability.
- 2. Description of the Prior Art
- There are three main types of biopsy procedures. In a first type, a conventional surgical incision is made and the patient's body is opened so that a surgeon may retrieve one or more large pieces of the tumor or lesion to be tested for malignancy. This type of biopsy is very invasive, expensive to perform, and requires a considerable recovery time. Inventive endeavors in the field have resulted in two improved procedures that substantially reduce the invasiveness of the biopsy procedure, as well as the expense of the procedure and the length of the recovery time.
- The first improved procedure involves the cutting or shearing of one or more visible pieces of the tumor or lesion by a relatively large bore needle. This type of biopsy is known as a core tissue biopsy and is performed with a core tissue biopsy needle. The pieces of tissue are usually about one to three millimeters in length and are thus visible to the unaided eye. They cannot be immediately examined under a microscope because they are too thick for light to pass therethrough. Accordingly, they must first be sliced into a plurality of very thin slices by a tissue-slicing machine. After slicing, they are then stained with a tissue fixative e.g., formalin, glutaraldehyde, etc., and placed upon a microscope slide for diagnostic purposes. For a period of time sufficient to cause crosslinking of connective tissue proteins present in the tissue, the fixed tissue is sliced into thin sections approximately eight (8) microns thick, the tissue sections are mounted on and cell-selective histiological stains are applied to stain the tissue prior to microscopic examination. This non-frozen tissue preparation technique typically requires twenty four to forty eight (24-48) hours to complete so the pathologist's diagnosis of the breast lesion may not be available until twenty four to seventy two (24-72) hours after the biopsy specimen was removed from the breast. Accordingly, histopathological examination and diagnosis of breast lesions may be much more time-consuming than the histopathological examination and diagnosis of other types of lesions.
- The use of a core tissue biopsy needle thus represents a significant improvement over the more invasive surgical removal of tumor or lesion specimens. However, the need to slice the specimens causes a delay in providing the diagnosis, due to processing. Additionally, the diameter of core biopsy needles are typically larger than the diameter of fine needle aspiration (FNA) needles, thereby increasing the risk of procedure-related complications including bleeding, pneumothorax, and bile leakage. Moreover, the use of core biopsy needles necessitates the purchase and maintenance of tissue slicing machines. The material must be removed from the needle, deposited onto the machine, machine-sliced, removed from the machine after slicing, stained, and deposited onto a microscope slide.
- One example of a core tissue biopsy needle is disclosed in U.S. Pat. No. 5,320,110 to Wang. The Wang structure has utility in performing a pleural tissue biopsy by cutting tissue samples of the parietal pleura. Wang teaches a two needle (tube-in-tube) system having a sharp edge to fix tissue while a second needle is advanced to shear off a piece of the tissue. The device does not rely solely on a vacuum to draw in material as in an FNA biopsy needle and tissue is sheared off in sizeable, visible pieces, i.e., not at the cellular level.
- More particularly, in the Wang device, a hook engages the pleural tissue and an outer cannula is advanced to cut off the hooked piece of pleural tissue. This two needle system is designed to reduce the chances of a pneumothorax and thus represents a significant improvement over earlier biopsy techniques. However, the diameter of the Wang needle as described is about 4.5 mm, which is considerably larger than an FNA biopsy needle of the novel type disclosed herein which is typically no larger than 20-22 gauge. The Wang needle is not designed as a fine needle aspiration device but is designed to cut off pieces of lung pleura. A large diameter needle like the Wang device measuring about 4.5 mm in diameter is inappropriate for fine needle biopsy procedures due to the high risk of complications from a large tissue puncture including bleeding, pneumothorax and bile leakage.
- The Wang structure includes a notch formed in a first side of the large bore needle and a hole in an opposite side thereof. The tissue to be cut extends into the notch and is sliced off when the outer needle or cannula is advanced as aforesaid. No such opposing hole can be provided in an FNA biopsy needle because such hole would allow the escape of cellular material when it is deposited directly from the syringe barrel onto a microscope slide in which the distal tip bevel and side notch must point in the same direction.
- The distal tip of the Wang outer needle is not hollow and therefore no tissue cutting occurs at said distal tip. All tissue cutting occurs at the side of the Wang needle where the notch is positioned. Thus, the Wang needle collects relatively large samples in a knifing action, and performs no scraping action capable of collecting samples at the cellular level.
- Neither Wang nor any other known two needle systems include both an open distal end and a port for cutting tissue nor is any core biopsy system capable of collecting samples of cellular thickness. It should also be observed that the Wang needle is attached to a syringe barrel and includes a pressure flap.
- Other biopsy tools that collect large specimens include spring-loaded core biopsy guns. An example of a vacuum-assisted biopsy device is the Mammotome Biopsys® breast biopsy device.
- The third technique is called fine needle aspiration (FNA) biopsy and is performed with an FNA biopsy needle. An FNA biopsy needle scrapes cells from the tumor or lesion that are so small as to be invisible to the unaided eye. Advantageously, the cellular material is already very thin when it is collected so there is no need to slice it to a thinner size prior to viewing it on a microscope slide because light can already pass through the thin cell layer. The cellular material is deposited onto a microscope slide directly from the FNA biopsy needle, stained, and viewed so that there is less time to the final biopsy report because the slicing machine and all of the handling steps necessitated thereby are eliminated. Trauma to the patient is greatly reduced because of smaller needle diameter and because cells are scraped instead of tissue being cut in thick pieces. Complication risk is also minimized or eliminated due to smaller nozzle diameters.
- FNA biopsy needles collect samples by aspiration; a vacuum applied to the proximal end of a hollow needle pulls severed cellular material from the lesion into the lumen of the needle. The needle is then retracted from the soft tissue so that the cellular material in the lumen can be removed for analysis. If more samples of the lesion are needed, the biopsy needle is reintroduced into the lesion.
- The primary distinction between an FNA biopsy needle and a core tissue biopsy needle is that the latter cuts or slices relatively large pieces of tissue from a lesion or tumor whereas the former scrapes cellular material from a lesion or tumor. By way of analogy, a core needle aspiration biopsy needle is like a knife that cuts slices of cheese and an FNA biopsy needle is like a cheese grater that scrapes small flakes of cheese.
- Sometimes, however, the FNA biopsy procedure fails to collect a sample of sufficient size to enable definitive pathological analysis. When that happens, the physician must repeat the procedure, causing additional trauma to the body part undergoing biopsy and creating an additional risk of an adverse event.
- The primary reason that conventional FNA biopsy needles are sometimes unable to collect sufficient cellular material is that the only cutting action occurs at the hollow distal tip of the needle. Thus, no scraping occurs during the retraction stroke of the needle, i.e., scraping occur only in the forward thrust.
- Although FNA biopsy needles represent a significant improvement over more invasive procedures for performing biopsies on suspect lesions or tumors, there remains a need for an improved FNA biopsy needle that increases the amount of sample that may be recovered per entrance into the lesion with one needle insertion so that multiple insertions need not be performed to complete a biopsy procedure.
- However, in view of the prior art considered as a whole at the time the present invention was made, it was not obvious to those of ordinary skill in the pertinent art how the standard FNA biopsy needle could be improved.
- The longstanding but heretofore unfulfilled need for a biopsy needle having enhanced cellular material collection capability is now met by a new, useful, and nonobvious invention. The novel aspiration biopsy needle includes a single needle of elongate, hollow construction having a proximal end and a beveled distal end. The beveled distal end of the needle is open and therefore forms a first sharp edge adapted to scrape cellular material when the needle is inserted into tissue. The needle is displaced from a proximal position to a distal position during insertion. The needle has a uniform diameter along a substantial part of its extent. A slot is formed in the needle near the beveled distal end; the slot is transversely disposed relative to a longitudinal axis of the needle. The slot is also angled relative to a transverse axis of the needle such that a bottom of the slot is positioned distal to an opening of the slot. The opening of the slot includes a second sharp edge adapted to scrape tissue of cellular size when the needle is displaced from a distal position to a proximal position. The novel structure further includes conventional means for applying a vacuum to a proximal end of the needle so that cellular material removed by the first sharp edge during proximal-to-distal travel of the needle is pulled into a lumen of the needle and so that cellular material removed by the second sharp edge during distal-to-proximal travel of the needle is also pulled into the lumen. However, the novel structure also has utility when no vacuum means is employed, i.e., even if it is not affixed to a syringe barrel.
- Accordingly, the cellular material is deposited from the lumen of the single FNA needle onto a slide for microscopic inspection in the absence of any need to slice said cellular material and to place said cellular material, following staining, into a formative to preserve the tissue.
- In all embodiments, the slot has a circumferential extent of about one half the circumference of the needle.
- In a first embodiment, the second sharp edge is coincident with the exterior surface of the needle.
- In a second embodiment, the second sharp edge is raised with respect to the exterior surface of said needle, and in a third embodiment, the sharp edge is recessed with respect to said exterior surface.
- In a fourth embodiment, the slot is also angled relative to a transverse axis of the needle such that a bottom of the slot is positioned proximal to an opening of the slot and the second sharp edge thereby created is coincident with the exterior surface if the needle.
- In fifth and sixth embodiments, the second sharp edge of the fourth embodiment is elevated and recessed, respectively, relative to the exterior surface of the needle.
- In a seventh embodiment, a first slot is formed in the needle as in the first embodiment and a second slot is formed in the needle as in the fourth embodiment. The first and second slots are longitudinally spaced apart from one another.
- In an eighth embodiment, a transversely disposed channel is formed in the needle and provides a second and a third sharp edge that are coincident with the exterior surface of the needle.
- In ninth and tenth embodiments, the second and third sharp edges, respectively, are elevated with respect to the exterior surface of the needle and in eleventh and twelfth embodiments, the second and third sharp edges, respectively, are recessed with respect to said exterior surface.
- In additional embodiments, the second sharp edge is mounted for pivotal movement about a transversely disposed hinge. The hinge enables the second sharp edge to open wider relative to its non-hinged position so that it may scrape off larger numbers of cellular material as the needle is displaced in a distal-to-proximal direction.
- In still further embodiments, the third sharp edge is mounted for pivotal movement about a transversely disposed hinge and in additional embodiments, both the second and third sharp edges are so mounted.
- A primary object of the invention is to provide a fine needle aspiration biopsy needle that collects a greater quantity of cellular material per needle insertion than conventional fine needle aspiration biopsy needles.
- A closely related object is to accomplish the foregoing object by making a structural change to an existing FNA biopsy needle so that physicians will have a sense of familiarity when employing the improved needle.
- A more specific object is to provide an FNA biopsy needle capable of collecting cellular material as the needle is reciprocated along its longitudinal axis at a tissue collection site.
- These and other important objects, advantages, and features of the invention will become clear as this description proceeds.
- The invention accordingly comprises the features of construction, combination of elements, and arrangement of parts that will be exemplified in the description set forth hereinafter and the scope of the invention will be indicated in the claims.
- For a fuller understanding of the nature and objects of the invention, reference should be made to the following detailed description, taken in connection with the accompanying drawings, in which:
- FIG. 1 is a perspective view of a first embodiment of the novel aspiration biopsy needle;
- FIG. 2 is an enlarged perspective view of the distal end of the needle of said first embodiment;
- FIG. 3 is an enlarged longitudinal sectional view of the parts depicted in FIG. 2;
- FIG. 4 is an enlarged perspective view of the distal end of a second embodiment;
- FIG. 5 is an enlarged longitudinal sectional view of the parts depicted in FIG. 4;
- FIG. 6 in an enlarged longitudinal sectional view of a third embodiment;
- FIG. 7 is an enlarged longitudinal sectional view of a fourth embodiment;
- FIG. 8 is an enlarged longitudinal sectional view of a fifth embodiment;
- FIG. 9 is an enlarged longitudinal sectional view of a sixth embodiment;
- FIG. 10 is an enlarged longitudinal sectional view of a seventh embodiment;
- FIG. 11 is an enlarged longitudinal sectional view of a eighth embodiment;
- FIG. 12 is an enlarged sectional view of a ninth embodiment;
- FIG. 13 is an enlarged sectional view of a tenth embodiment;
- FIG. 14 is an enlarged sectional view of an eleventh embodiment;
- FIG. 15 is an enlarged sectional view of a twelfth embodiment;
- FIG. 16 is an enlarged sectional view of a thirteenth embodiment; and
- FIG. 17 is a diagrammatic view of a fourteenth embodiment where the novel biopsy device is used with an endoscope.
- Referring now to FIGS.1-3, it will there be seen that the
reference numeral 10 denotes a first illustrative embodiment of the present invention. - The
proximal end 12 ofaspiration biopsy needle 10 is mounted in a LUERLOK® adapter 13 or equivalent structure to which a vacuum is applied from a remote source of negative pressure, not shown, when the leading ordistal end 14 of said needle is inserted into a suspect lesion in soft tissue. The sharpleading end 14 is beveled in a well-known way to form a first sharp edge that scrapes cellular material from the lesion as it travels therethrough in a proximal-to-distal direction. - A vacuum applied to
adapter 13 pulls cellular material severed from the lesion intolumen 16 of the needle. The well-known prior art procedure ends at this point, i.e., the needle having a sample of the lesion in its lumen is retracted from the soft tissue and the sample is delivered to a lab for analysis. Additional sample-taking requires additional insertions of the needle into the lesion. - A first innovation of this invention includes
slot 18 formed inneedle 10, near firstsharp edge 14 thereof.Slot 18 is transversely disposed relative to a longitudinal axis of the needle. A lower end or bottom of the slot is distal to the open upper end thereof. A secondsharp edge 20 is formed at the distal edge of the upper end of the slot. Accordingly secondsharp edge 20 scrapes cellular material from a lesion when the needle is retracted, i.e., when the needle is displaced along its longitudinal axis in a distal-to-proximal direction. - It should therefore be understood that a physician may reciprocate
needle 10 along its longitudinal axis, collecting cells of a suspect lesion that are scraped off by the firstsharp edge 14 during the proximal-to-distal portion of each reciprocation, and collecting cellular aspirate of said lesion that are scraped by secondsharp edge 20 during the distal-to-proximal portion of each reciprocation. Thus, the chances of collecting a quantity of lesion that is sufficient for analysis is greatly enhanced by the provision of secondsharp edge 20. - The circumferential extent of
slot 18 is approximately equal to half of the circumference ofneedle 10, but that structural feature ofslot 18 is not critical to this invention; the circumferential extent of said slot could be more or less than that described and depicted. - As perhaps best depicted in FIG. 3, second
sharp edge 20 is coincident or flush with the exterior surface ofneedle 10 in this first embodiment. - FIG. 4 provides a perspective view of a second embodiment of
needle 10 where secondsharp edge 20 a is elevated with respect to the exterior surface ofneedle 10 and FIG. 5 provides a longitudinal sectional view of said second embodiment. The protrusion of secondsharp edge 20 a above the exterior surface of the needle ensures that the cellular material collected when using this second embodiment should be greater than the amount of cellular material collected when using the first embodiment. - FIG. 6 provides a longitudinal sectional view of a third embodiment where second
sharp edge 20 b is recessed with respect to said exterior surface. The lesion, not shown, is under compression asneedle 10 penetrates it. Accordingly, an amount of tissue will enter intoslot 18 and be scraped off during distal-to-proximal travel ofneedle 10, even thoughsharp edge 20 b is recessed with respect to the exterior surface of the needle. - FIG. 7 depicts a fourth embodiment where a
slot 18 a is formed transversely to the longitudinal axis ofneedle 10 as in the first embodiment, but the axis of symmetry ofslot 18 a is normal to the axis of symmetry ofslot 18. In other words, the bottom ofslot 18 a is proximal to the open upper end ofslot 18 a. Accordingly, a third sharp edge, denoted 20 c, is formed. Thirdsharp edge 20 c is auxiliary to firstsharp edge 14 in that said third sharp edge scrapes cellular material from a lesion during proximal-to-distal travel ofneedle 10. - FIGS. 8 and 9 depict fifth and sixth embodiments, respectively, where third
sharp edges needle 10. - A seventh embodiment, depicted in FIG. 10, includes
first slot 18 of the first embodiment andsecond slot 18 a of the fourth embodiment. The respective axes of symmetry of said slots are normal to one another and saidslots sharp edge 20 is elevated or recessed relative to the exterior surface ofneedle 10, as is thirdsharp edge 20 c. - FIG. 11 depicts an eighth embodiment. This embodiment, like the seventh, provides two auxiliary sharp edges to augment
beveled edge 14. However, it provides a single transversely disposed channel as distinguished from two transversely disposed slots. Thus, instead ofslot 18, transversely disposedchannel 21 is formed in saidneedle 10.Channel 21 includes a pair of longitudinally spaced apart undercuts that respectively form second and thirdsharp edges sharp edge 20 performs in the same way as secondsharp edge 20 of the first embodiment, i.e., it functions during distal-to-proximal travel ofneedle 10. Thirdsharp edge 20 c, however, functions in the same way as thirdsharp edge 20 c of the fourth embodiment, i.e., during proximal-to-distal travel. Thus, firstsharp edge 14 and thirdsharp edge 20 c function during proximal-to-distal travel, but the amount of cellular material scraped from the lesion during such sharp action may not be the same. This eighth embodiment is also similar to the seventh embodiment because second and thirdsharp edges needle 10. - FIGS. 12 and 13 depict ninth and tenth embodiments, respectively, where second
sharp edge 20 f and thirdsharp edge 20 g are elevated, respectively, with respect to the exterior surface ofneedle 10. - FIGS. 14 and 15 depict eleventh and twelfth embodiments, respectively, where second
sharp edge 20 b and thirdsharp edge 20 e are recessed, respectively, with respect to the exterior surface ofneedle 10. - FIG. 16 provides a longitudinal sectional view where second
sharp edge 20 is pivotally mounted by transversely disposed hinge means 22 so that secondsharp edge 20 may open as indicated by arcuatedirectional arrow 24 to the position indicated in dotted lines to scrape larger numbers of cells from the suspect lesion during distal-to-proximal travel of the biopsy needle. - Second
sharp edge 20 is biased against outward rotation. Various bias means such as different types of springs could be employed but the preferred bias means is a living hinge formed of nitenol or other suitable material. The hinge is held in its closed, FIG. 16 position when the needle is traveling in a proximal-to-distal direction, i.e., as the needle is inserted, but opens due to frictional forces created by the lesion as depicted in dotted lines in FIG. 16 when the needle is retracted, i.e., when the needle is displaced in a distal-to-proximal direction. - Alternatively, a control means, not depicted, under the control of the physician, causes second
sharp edge 20 to pivot about hinge means 22 in small incremental amounts so that the depth of the cellular aspirate taken from the lesion is controlled with precision. - It should be understood that, in addition to first
sharp edge 20 of the first embodiment,sharp edges - Moreover, the cell-collection ability of each
sharp edge - As drawn, the cut that forms
sharp edges sharp edge 14 ofneedle 10. Accordingly, said sharp edges scrape tissue with the same degree of efficiency as firstsharp edge 14. The scraping action provided by these sharp edges is during the distal-to-proximal stroke ofneedle 10 whereas the scraping action provided by firstsharp edge 14 is during the proximal-to-distal stroke. - The cut that forms third
sharp edges sharp edges sharp edge 14 cuts cellular material. - In this way, a physician can reciprocate the needle along its longitudinal axis and obtain multiple cellular-sized samples of tissue for analysis.
-
Needle 10 is used by inserting it into a lesion in a well-known way and by reciprocating it multiple times along its longitudinal axis. Each proximal-to-distal displacement causes firstsharp edge 14 and thirdsharp edges lumen 16. Each distal-to-proximal motion, however, causes secondsharp edges lumen 16 throughslot 18, slot 18 a, orchannel 21, depending upon the embodiment in use, under the influence of the vacuum. Thus, in a single reciprocation, novelaspiration biopsy needle 10 collects at least twice the amount of lesion material as would a conventional aspiration biopsy needle. The quantity of scraped-off lesion parts collected is increased with each subsequent reciprocation. In this way, a sufficient sample may be taken with a single needle insertion followed by multiple reciprocations. - Additional quantities of lesion material may also be collected by rotating
needle 10 about its longitudinal axis of symmetry after a first set of reciprocations has been made. Additional rotations may follow additional reciprocations, it being understood that each rotational adjustment exposes an unscraped mass of lesion until the needle has been through three hundred sixty degrees of rotation. - FIG. 17 depicts how an endoscope or
laparoscope 24 is used in connection with fine needleaspiration biopsy device 10. The well-known attachments to the endoscope such as a light source, camera unit, monitor, and the like are not depicted to avoid cluttering the drawing.Syringe 26 is of conventional construction and is connected to an elongate, flexible polymer tube or aguide tube 28 of the hollow, coiled cable type.Tube wire 28 may be up to one hundred fifty centimeters (150 cm) in length and is inserted into the operating channel of the endoscope orlaparoscope 24 as depicted. Novel fineaspiration biopsy device 10 is secured to the distal end of the tube or guidewire 28. Although it is difficult to pushdevice 10 to retrieve cellular material fromlesion 30 as in the earlier embodiments, it can be pulled to collect such cellular material because it cuts at the cellular level in both forward and rearward motions. Pulling ofguide tube 28 results in rearward motion ofdevice 10. - These improvements represent revolutionary improvements in the art of aspiration biopsy needles and this invention is therefore entitled to the status of a pioneering invention. Accordingly, the claims that follow are entitled to broad interpretation, as a matter of law, to protect the heart or essence of the invention.
- It will thus be seen that the objects set forth above, and those made apparent from the foregoing description, are efficiently attained. Since certain changes may be made in the above construction without departing from the scope of the invention, it is intended that all matters contained in the foregoing description or shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.
- It is also to be understood that the following claims are intended to cover all of the generic and specific features of the invention herein described, and all statements of the scope of the invention which, as a matter of language, might be said to fall therebetween.
- Now that the invention has been described,
Claims (9)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/708,711 US6908440B2 (en) | 2001-08-09 | 2004-03-19 | Dual action aspiration biopsy needle |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/682,252 US20030032895A1 (en) | 2001-08-09 | 2001-08-09 | Dual action aspiration biopsy needle |
US09/683,282 US6592608B2 (en) | 2001-12-07 | 2001-12-07 | Bioabsorbable sealant |
US10/065,155 US6709408B2 (en) | 2001-08-09 | 2002-09-23 | Dual action aspiration biopsy needle |
US10/708,711 US6908440B2 (en) | 2001-08-09 | 2004-03-19 | Dual action aspiration biopsy needle |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/065,155 Division US6709408B2 (en) | 2001-08-09 | 2002-09-23 | Dual action aspiration biopsy needle |
Publications (2)
Publication Number | Publication Date |
---|---|
US20040167434A1 true US20040167434A1 (en) | 2004-08-26 |
US6908440B2 US6908440B2 (en) | 2005-06-21 |
Family
ID=32028496
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/065,155 Expired - Lifetime US6709408B2 (en) | 2001-08-09 | 2002-09-23 | Dual action aspiration biopsy needle |
US10/708,711 Expired - Lifetime US6908440B2 (en) | 2001-08-09 | 2004-03-19 | Dual action aspiration biopsy needle |
US10/708,710 Expired - Lifetime US6872185B2 (en) | 2001-08-09 | 2004-03-19 | Dual action aspiration biopsy needle |
US10/708,712 Expired - Lifetime US6890309B2 (en) | 2001-08-09 | 2004-03-19 | Method for scraping cellular material from tissue |
US10/905,599 Abandoned US20050090765A1 (en) | 2001-08-09 | 2005-01-12 | Dual Action Aspiration Biopsy Needle |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/065,155 Expired - Lifetime US6709408B2 (en) | 2001-08-09 | 2002-09-23 | Dual action aspiration biopsy needle |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/708,710 Expired - Lifetime US6872185B2 (en) | 2001-08-09 | 2004-03-19 | Dual action aspiration biopsy needle |
US10/708,712 Expired - Lifetime US6890309B2 (en) | 2001-08-09 | 2004-03-19 | Method for scraping cellular material from tissue |
US10/905,599 Abandoned US20050090765A1 (en) | 2001-08-09 | 2005-01-12 | Dual Action Aspiration Biopsy Needle |
Country Status (5)
Country | Link |
---|---|
US (5) | US6709408B2 (en) |
EP (1) | EP1542592A4 (en) |
AU (1) | AU2003267265A1 (en) |
CA (1) | CA2499993C (en) |
WO (1) | WO2004026142A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060200042A1 (en) * | 2005-03-04 | 2006-09-07 | Ethicon Endo-Surgery, Inc. | Biopsy device incorporating an adjustable probe sleeve |
EP1829487A1 (en) * | 2006-03-03 | 2007-09-05 | Ethicon Endo-Surgery, Inc. | Biopsy device |
US20080114264A1 (en) * | 2005-03-04 | 2008-05-15 | Ethicon Endo-Surgery, Inc. | Biopsy Device With Variable Side Aperture |
US7766843B2 (en) | 2006-03-03 | 2010-08-03 | Ethicon Endo-Surgery, Inc. | Biopsy method |
US9060759B2 (en) | 2011-03-31 | 2015-06-23 | Cook Medical Technologies Llc | Adjustable-throw biopsy needle |
US10092276B2 (en) | 2013-03-15 | 2018-10-09 | Cook Medical Technologies Llc | Tissue acquisition device with indication system |
Families Citing this family (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7189206B2 (en) | 2003-02-24 | 2007-03-13 | Senorx, Inc. | Biopsy device with inner cutter |
US8282573B2 (en) | 2003-02-24 | 2012-10-09 | Senorx, Inc. | Biopsy device with selectable tissue receiving aperture orientation and site illumination |
US7695492B1 (en) * | 1999-09-23 | 2010-04-13 | Boston Scientific Scimed, Inc. | Enhanced bleed back system |
US20060183973A1 (en) * | 2001-01-12 | 2006-08-17 | Kamrava Michael M | Endoscopic devices and method of use |
US6709408B2 (en) * | 2001-08-09 | 2004-03-23 | Biopsy Sciences, Llc | Dual action aspiration biopsy needle |
WO2003077768A1 (en) | 2002-03-19 | 2003-09-25 | Bard Dublin Itc Limited | Biopsy device and biopsy needle module that can be inserted into the biopsy device |
ATE303099T1 (en) | 2002-03-19 | 2005-09-15 | Bard Dublin Itc Ltd | VACUUM BIOPSY DEVICE |
DE10314240A1 (en) | 2003-03-29 | 2004-10-07 | Bard Dublin Itc Ltd., Crawley | Pressure generating unit |
US20050222683A1 (en) * | 2004-03-31 | 2005-10-06 | Sdgi Holdings | Shape memory alloy disc replacement device |
US7670282B2 (en) * | 2004-06-14 | 2010-03-02 | Pneumrx, Inc. | Lung access device |
WO2006009688A2 (en) * | 2004-06-16 | 2006-01-26 | Pneumrx, Inc. | Intra-bronchial lung volume reduction system |
US7766891B2 (en) * | 2004-07-08 | 2010-08-03 | Pneumrx, Inc. | Lung device with sealing features |
EP1781182B1 (en) * | 2004-07-08 | 2019-11-13 | PneumRx, Inc. | Pleural effusion treatment device |
EP1776047B1 (en) | 2004-07-09 | 2012-12-05 | Bard Peripheral Vascular, Inc. | Transport system for biopsy device |
US20060052722A1 (en) * | 2004-09-09 | 2006-03-09 | Brautigam Robert T | Ultra-fine micropsy needle |
US20060064031A1 (en) * | 2004-09-17 | 2006-03-23 | Miller Stuart H | Biopsy needle |
JP4874259B2 (en) | 2004-11-23 | 2012-02-15 | ヌームアールエックス・インコーポレーテッド | Steerable device for accessing the target site |
WO2006081556A2 (en) * | 2005-01-28 | 2006-08-03 | The General Hospital Corporation | Biopsy needle |
US7517321B2 (en) | 2005-01-31 | 2009-04-14 | C. R. Bard, Inc. | Quick cycle biopsy system |
US8262585B2 (en) | 2005-08-10 | 2012-09-11 | C. R. Bard, Inc. | Single-insertion, multiple sampling biopsy device with linear drive |
EP1921999B1 (en) | 2005-08-10 | 2015-08-05 | C.R.Bard, Inc. | Single-insertion, multiple sampling biopsy device usable with various transport systems |
WO2007021905A2 (en) | 2005-08-10 | 2007-02-22 | C.R. Bard Inc. | Single-insertion, multiple sample biopsy device with integrated markers |
US8187203B2 (en) * | 2006-02-24 | 2012-05-29 | Mcclellan W Thomas | Biopsy needle system, biopsy needle and method for obtaining a tissue biopsy specimen |
US7473232B2 (en) * | 2006-02-24 | 2009-01-06 | Boston Scientific Scimed, Inc. | Obtaining a tissue sample |
US7670299B2 (en) * | 2006-03-07 | 2010-03-02 | Ethincon Endo-Surgery, Inc. | Device for minimally invasive internal tissue removal |
US7806834B2 (en) * | 2006-03-07 | 2010-10-05 | Devicor Medical Products, Inc. | Device for minimally invasive internal tissue removal |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US8157837B2 (en) * | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US7465278B2 (en) * | 2006-03-29 | 2008-12-16 | Ethicon Endo-Surgery, Inc. | Device for minimally invasive internal tissue removal |
JP4504941B2 (en) * | 2006-04-25 | 2010-07-14 | テルモ株式会社 | Thrombus aspiration catheter |
WO2008024684A2 (en) | 2006-08-21 | 2008-02-28 | C.R. Bard, Inc. | Self-contained handheld biopsy needle |
US20080058673A1 (en) * | 2006-08-29 | 2008-03-06 | Lex Jansen | Tissue extraction device and method of using the same |
US20080058674A1 (en) * | 2006-08-29 | 2008-03-06 | Lex Jansen | Tissue extraction device and method of using the same |
US8485987B2 (en) | 2006-10-06 | 2013-07-16 | Bard Peripheral Vascular, Inc. | Tissue handling system with reduced operator exposure |
US7914463B2 (en) * | 2006-10-23 | 2011-03-29 | Clipius Technologies, Inc. | Double core biopsy instrumentation kit |
WO2008051987A2 (en) | 2006-10-24 | 2008-05-02 | C.R. Bard Inc. | Large sample low aspect ratio biopsy needle |
US9345457B2 (en) * | 2006-12-13 | 2016-05-24 | Devicor Medical Products, Inc. | Presentation of biopsy sample by biopsy device |
WO2009058436A1 (en) * | 2007-11-02 | 2009-05-07 | Sharp Surgical Devices, Inc. | Devices, methods, and kits for a biopsy device |
US20090177114A1 (en) * | 2007-12-13 | 2009-07-09 | Yem Chin | Echogenic needle aspiration device |
US8241225B2 (en) | 2007-12-20 | 2012-08-14 | C. R. Bard, Inc. | Biopsy device |
US7854706B2 (en) | 2007-12-27 | 2010-12-21 | Devicor Medical Products, Inc. | Clutch and valving system for tetherless biopsy device |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US11298113B2 (en) | 2008-10-01 | 2022-04-12 | Covidien Lp | Device for needle biopsy with integrated needle protection |
US9186128B2 (en) | 2008-10-01 | 2015-11-17 | Covidien Lp | Needle biopsy device |
US9782565B2 (en) | 2008-10-01 | 2017-10-10 | Covidien Lp | Endoscopic ultrasound-guided biliary access system |
US8968210B2 (en) | 2008-10-01 | 2015-03-03 | Covidien LLP | Device for needle biopsy with integrated needle protection |
US9332973B2 (en) | 2008-10-01 | 2016-05-10 | Covidien Lp | Needle biopsy device with exchangeable needle and integrated needle protection |
US10368890B2 (en) * | 2008-12-16 | 2019-08-06 | Nico Corporation | Multi-functional surgical device for neurosurgical and spinal surgery applications |
US20100241028A1 (en) * | 2008-12-19 | 2010-09-23 | Superdimension, Ltd. | Navigable Tissue Treatment Tools |
US8690793B2 (en) | 2009-03-16 | 2014-04-08 | C. R. Bard, Inc. | Biopsy device having rotational cutting |
GB2469062B (en) * | 2009-03-31 | 2011-06-15 | Igal Gigi | Tissue sampling device and method |
AU2009344276B2 (en) | 2009-04-15 | 2014-06-05 | C.R. Bard, Inc. | Biopsy apparatus having integrated fluid management |
US9301736B2 (en) | 2009-04-30 | 2016-04-05 | Joseph G. Rusnak | Fine needle biopsy with adaptor |
US20100280408A1 (en) * | 2009-04-30 | 2010-11-04 | Rusnak Joseph G | Fine needle biopsy system and method of use |
CN104622599B (en) | 2009-05-18 | 2017-04-12 | 纽姆克斯股份有限公司 | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8206316B2 (en) | 2009-06-12 | 2012-06-26 | Devicor Medical Products, Inc. | Tetherless biopsy device with reusable portion |
EP3572002A1 (en) | 2009-08-12 | 2019-11-27 | C.R. Bard Inc. | Biopsy apparatus having integrated thumbwheel mechanism for manual rotation of biopsy cannula |
US8485989B2 (en) | 2009-09-01 | 2013-07-16 | Bard Peripheral Vascular, Inc. | Biopsy apparatus having a tissue sample retrieval mechanism |
US8430824B2 (en) | 2009-10-29 | 2013-04-30 | Bard Peripheral Vascular, Inc. | Biopsy driver assembly having a control circuit for conserving battery power |
US9072506B1 (en) | 2009-09-02 | 2015-07-07 | C. R. Bard, Inc. | Biopsy apparatus including a biopsy device having a sample receiving notch with a tissue anchor |
US8597206B2 (en) | 2009-10-12 | 2013-12-03 | Bard Peripheral Vascular, Inc. | Biopsy probe assembly having a mechanism to prevent misalignment of components prior to installation |
KR101148187B1 (en) * | 2009-12-03 | 2012-05-23 | 주식회사 엠아이텍 | Biopsy needle device |
WO2011073725A1 (en) * | 2009-12-15 | 2011-06-23 | Luc Malarme | Handheld automated biopsy device |
EP2552322B1 (en) | 2010-03-30 | 2016-11-16 | Martin L. Flatland | Tissue excision device |
IES20110141A2 (en) * | 2010-04-06 | 2011-10-12 | Cook Medical Technologies Llc | Endoscopic ultrasound-guided biopsy needle |
US9980707B2 (en) | 2011-04-04 | 2018-05-29 | Cook Medical Technologies Llc | Endoscopic ultrasound-guided biopsy needle |
FR2967567B1 (en) * | 2010-11-19 | 2012-12-14 | Jean-Charles Persat | VECTOR FOR TISSUE PARTICULARLY ADIPOSE |
WO2012103483A2 (en) | 2011-01-28 | 2012-08-02 | The General Hospital Corporation | Apparatus and method for tissue biopsy |
MX347856B (en) | 2011-01-28 | 2017-05-16 | Massachusetts Gen Hospital | Method and apparatus for skin resurfacing. |
US9282948B2 (en) | 2011-02-22 | 2016-03-15 | Cook Medical Technologies Llc | Total core biopsy device and method of use |
CN103249365B (en) * | 2011-03-25 | 2015-06-24 | 奥林巴斯医疗株式会社 | Tool for biopsy and tissue collecting method |
CN103841880A (en) * | 2011-05-03 | 2014-06-04 | Endosee股份有限公司 | Method and apparatus for hysteroscopy and endometrial biopsy |
US10448930B2 (en) | 2011-05-04 | 2019-10-22 | Cook Medical Technologies Llc | Methods and devices for maximizing tissue collection in partial-core biopsy needles |
CN103228222B (en) * | 2011-07-06 | 2014-06-18 | 奥林巴斯医疗株式会社 | Sampling device |
EP2729098B1 (en) * | 2011-07-08 | 2016-08-17 | Doheny Eye Institute | Ocular lens cutting device |
WO2013013199A2 (en) * | 2011-07-21 | 2013-01-24 | The General Hospital Corporation | Method and apparatus for subsurface tissue sampling |
BR112014001248B1 (en) | 2011-07-21 | 2020-12-08 | The General Hospital Corporation | apparatus and method for affecting subcutaneous adipose tissue |
US20130072912A1 (en) * | 2011-09-19 | 2013-03-21 | Daniel A. Del Vecchio | Rasping cannula |
US9445837B2 (en) | 2012-03-16 | 2016-09-20 | Nfinium Vascular Technologies Llc | Surgical needle with enhanced ultrasound reflectivity |
US9622646B2 (en) | 2012-06-25 | 2017-04-18 | Coopersurgical, Inc. | Low-cost instrument for endoscopically guided operative procedures |
US9192451B2 (en) * | 2012-07-20 | 2015-11-24 | Schubert L. Sapian | Oscillating blade for cutting periodontal ligaments and luxating tooth roots |
US9615969B2 (en) | 2012-12-18 | 2017-04-11 | Novartis Ag | Multi-port vitrectomy probe with dual cutting edges |
WO2014130359A1 (en) | 2013-02-20 | 2014-08-28 | Cytrellis Biosystems, Inc. | Methods and devices for skin tightening |
NL2010444C2 (en) | 2013-03-13 | 2014-09-16 | D O R C Dutch Ophthalmic Res Ct International B V | EYE-SURGICAL CUTTING TOOL. |
WO2014158951A1 (en) | 2013-03-14 | 2014-10-02 | Muffin Incorporated | Echogenic surfaces with pressed-dimple formations |
EP3498176B1 (en) | 2013-03-20 | 2021-04-28 | Bard Peripheral Vascular, Inc. | Biopsy device |
WO2014175698A1 (en) | 2013-04-26 | 2014-10-30 | 서울대학교병원 | Biopsy needle |
BR112016002695B1 (en) | 2013-08-09 | 2022-09-20 | Cytrellis Biosystems, Inc | DEVICE WITH AN ABLATIVE DEVICE, A REMOVAL DEVICE AND A POSITIONING DEVICE |
US9795503B2 (en) | 2013-10-18 | 2017-10-24 | Rodolfo Alfredo PEREZ GROSSMANN | Method and apparatus for trabeculectomy and suprachoroidal shunt surgery |
CA2965315C (en) * | 2013-11-04 | 2020-06-23 | The Board Of Regents Of The University Of Texas System | Device and methods for precise control of medical procedures |
EP3808281B1 (en) | 2013-11-05 | 2024-01-10 | C. R. Bard, Inc. | Biopsy device having integrated vacuum |
US9993231B2 (en) | 2013-11-20 | 2018-06-12 | Covidien Lp | Devices, systems, and methods for navigating a biopsy tool to a target location and obtaining a tissue sample using the same |
US10953143B2 (en) | 2013-12-19 | 2021-03-23 | Cytrellis Biosystems, Inc. | Methods and devices for manipulating subdermal fat |
US9149260B2 (en) | 2014-02-28 | 2015-10-06 | 3DBiopsy LLC | Biopsy needle assembly |
US10278680B2 (en) | 2014-03-19 | 2019-05-07 | Covidien Lp | Devices, systems, and methods for navigating a biopsy tool to a target location and obtaining a tissue sample using the same |
KR20150116689A (en) * | 2014-04-08 | 2015-10-16 | 주식회사 파인메딕스 | Needle for EUS-FNA |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US9980699B2 (en) | 2014-09-12 | 2018-05-29 | Cook Medical Technologies Llc | Shaped echogenic needle groove |
CN104266860B (en) * | 2014-10-16 | 2017-06-16 | 南通大学 | A kind of spring brain piece sampler and its sampling method |
US9743915B2 (en) * | 2014-10-30 | 2017-08-29 | King Saud University | Advanced biopsy needle |
JP2017533774A (en) | 2014-11-14 | 2017-11-16 | サイトレリス バイオシステムズ,インコーポレーテッド | Device and method for skin ablation |
US9693898B2 (en) | 2014-11-19 | 2017-07-04 | Novartis Ag | Double-acting vitreous probe with contoured port |
PL3288467T3 (en) | 2015-05-01 | 2022-03-07 | C. R. Bard, Inc. | Biopsy device |
US10702305B2 (en) | 2016-03-23 | 2020-07-07 | Coopersurgical, Inc. | Operative cannulas and related methods |
US11166743B2 (en) | 2016-03-29 | 2021-11-09 | Cytrellis Biosystems, Inc. | Devices and methods for cosmetic skin resurfacing |
US11464954B2 (en) | 2016-09-21 | 2022-10-11 | Cytrellis Biosystems, Inc. | Devices and methods for cosmetic skin resurfacing |
US10945713B2 (en) | 2016-11-23 | 2021-03-16 | C. R. Bard, Inc. | Single insertion multiple sample biopsy apparatus |
EP3338646A1 (en) | 2016-12-21 | 2018-06-27 | National University of Ireland Galway | A biopsy device |
US11116483B2 (en) | 2017-05-19 | 2021-09-14 | Merit Medical Systems, Inc. | Rotating biopsy needle |
EP3624698A4 (en) | 2017-05-19 | 2021-06-09 | Merit Medical Systems, Inc. | Semi-automatic biopsy needle device and methods of use |
EP3624697B1 (en) | 2017-05-19 | 2024-02-14 | Merit Medical Systems, Inc. | Biopsy needle devices and methods of use |
US10639197B2 (en) | 2017-06-19 | 2020-05-05 | Alcon Inc. | Vitrectomy probe |
EP3673263B1 (en) * | 2017-08-24 | 2021-07-21 | Merck Patent GmbH | Method for providing a substance amount |
KR102243139B1 (en) * | 2018-08-08 | 2021-04-21 | 인제대학교 산학협력단 | Needle for endoscopy ultrasonic fine needle aspiration biopsy |
KR102475421B1 (en) | 2020-07-06 | 2022-12-07 | 충남대학교병원 | Production Metohd of Aspiration needle for preventing detachment of biopsy tissue |
US11314427B2 (en) * | 2020-08-21 | 2022-04-26 | Micron Technology, Inc. | Memory device with enhanced data reliability capabilities |
USD1019938S1 (en) * | 2021-05-14 | 2024-03-26 | Tecnovet, S.L. | Catheter |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470867A (en) * | 1964-11-23 | 1969-10-07 | Sidney Goldsmith | Biopsy needle |
US5458112A (en) * | 1994-08-15 | 1995-10-17 | Arrow Precision Products, Inc. | Biliary biopsy device |
US5843111A (en) * | 1995-06-19 | 1998-12-01 | Ophthalmic Research Center International Bv | Vitreous removing apparatus |
US6024751A (en) * | 1997-04-11 | 2000-02-15 | Coherent Inc. | Method and apparatus for transurethral resection of the prostate |
US6086543A (en) * | 1998-06-24 | 2000-07-11 | Rubicor Medical, Inc. | Fine needle and core biopsy devices and methods |
US6709408B2 (en) * | 2001-08-09 | 2004-03-23 | Biopsy Sciences, Llc | Dual action aspiration biopsy needle |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3683892A (en) | 1970-07-13 | 1972-08-15 | Battelle Development Corp | Device for the extraction of core samples |
US4340066A (en) | 1980-02-01 | 1982-07-20 | Sherwood Medical Industries Inc. | Medical device for collecting a body sample |
DE3026657A1 (en) * | 1980-07-14 | 1982-02-04 | Battelle-Institut E.V., 6000 Frankfurt | Puncturing needle for sample extraction - is hollow with recess with sharp edge below conventional opening |
US4603694A (en) | 1983-03-08 | 1986-08-05 | Richards Medical Company | Arthroscopic shaver |
US4702260A (en) | 1985-04-16 | 1987-10-27 | Ko Pen Wang | Flexible bronchoscopic needle assembly |
US4693257A (en) * | 1986-05-12 | 1987-09-15 | Markham Charles W | Needle aspiration biopsy device with enclosed fluid supply |
US4790329A (en) | 1987-06-12 | 1988-12-13 | Trustees Of Beth Israel Hospital | Adjustable biopsy localization device |
US4903709A (en) | 1988-09-21 | 1990-02-27 | Skinner Bruce A J | Biopsy method |
US5031634A (en) * | 1990-01-19 | 1991-07-16 | Beth Israel Hospital Assoc., Inc. | Adjustable biopsy needle-guide device |
GB2255282A (en) * | 1991-04-30 | 1992-11-04 | Al Sam Salam Zahroon | Advanced fine needle for tissue aspiration. |
US5320110A (en) | 1991-10-29 | 1994-06-14 | Wang Ko P | Pleural biopsy syringe-needles |
US5425376A (en) | 1993-09-08 | 1995-06-20 | Sofamor Danek Properties, Inc. | Method and apparatus for obtaining a biopsy sample |
US5394887A (en) * | 1994-01-14 | 1995-03-07 | Haaga; John R. | Biopsy needle |
US5560373A (en) * | 1994-04-11 | 1996-10-01 | De Santis; Stephen A. | Needle core biopsy instrument with durable or disposable cannula assembly |
US5615690A (en) * | 1995-02-15 | 1997-04-01 | Symbiosis Corporation | Tissue core biopsy cannula |
NL9500524A (en) * | 1995-03-16 | 1996-11-01 | Metracon C V | Aspiration tool for cell biopsy purposes. |
US6022324A (en) | 1998-01-02 | 2000-02-08 | Skinner; Bruce A. J. | Biopsy instrument |
JP2001149374A (en) * | 1999-11-29 | 2001-06-05 | Asahi Optical Co Ltd | Tissue-collection instrument for endoscope |
DE60013550D1 (en) * | 2000-03-09 | 2004-10-14 | Angiodynamics Inc | Ultrasound visualized surgical needle |
DE10032007A1 (en) * | 2000-07-01 | 2002-01-10 | Geuder Ag | Ophthalmic surgical instrument with needle for taking biopsies has outer and inner housings sliding telescopically and holding cannula leading to collection vessel |
US20050101879A1 (en) * | 2003-11-06 | 2005-05-12 | Shidham Vinod B. | Needle aspiration biopsy device and method |
-
2002
- 2002-09-23 US US10/065,155 patent/US6709408B2/en not_active Expired - Lifetime
-
2003
- 2003-09-17 EP EP03749737A patent/EP1542592A4/en not_active Withdrawn
- 2003-09-17 AU AU2003267265A patent/AU2003267265A1/en not_active Abandoned
- 2003-09-17 CA CA2499993A patent/CA2499993C/en not_active Expired - Lifetime
- 2003-09-17 WO PCT/US2003/029260 patent/WO2004026142A1/en not_active Application Discontinuation
-
2004
- 2004-03-19 US US10/708,711 patent/US6908440B2/en not_active Expired - Lifetime
- 2004-03-19 US US10/708,710 patent/US6872185B2/en not_active Expired - Lifetime
- 2004-03-19 US US10/708,712 patent/US6890309B2/en not_active Expired - Lifetime
-
2005
- 2005-01-12 US US10/905,599 patent/US20050090765A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470867A (en) * | 1964-11-23 | 1969-10-07 | Sidney Goldsmith | Biopsy needle |
US5458112A (en) * | 1994-08-15 | 1995-10-17 | Arrow Precision Products, Inc. | Biliary biopsy device |
US5843111A (en) * | 1995-06-19 | 1998-12-01 | Ophthalmic Research Center International Bv | Vitreous removing apparatus |
US6024751A (en) * | 1997-04-11 | 2000-02-15 | Coherent Inc. | Method and apparatus for transurethral resection of the prostate |
US6086543A (en) * | 1998-06-24 | 2000-07-11 | Rubicor Medical, Inc. | Fine needle and core biopsy devices and methods |
US6709408B2 (en) * | 2001-08-09 | 2004-03-23 | Biopsy Sciences, Llc | Dual action aspiration biopsy needle |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060200042A1 (en) * | 2005-03-04 | 2006-09-07 | Ethicon Endo-Surgery, Inc. | Biopsy device incorporating an adjustable probe sleeve |
US20080114264A1 (en) * | 2005-03-04 | 2008-05-15 | Ethicon Endo-Surgery, Inc. | Biopsy Device With Variable Side Aperture |
US7481775B2 (en) | 2005-03-04 | 2009-01-27 | Ethicon Endo-Surgery, Inc. | Biopsy device incorporating an adjustable probe sleeve |
US7517322B2 (en) | 2005-03-04 | 2009-04-14 | Ethicon Endo-Surgery, Inc. | Biopsy device with variable side aperture |
US7717861B2 (en) | 2005-03-04 | 2010-05-18 | Ethicon Endo-Surgery, Inc. | Biopsy device with variable side aperture |
US8287466B2 (en) | 2005-03-04 | 2012-10-16 | Devicor Medical Products, Inc. | Biopsy device with variable side aperture |
EP1829487A1 (en) * | 2006-03-03 | 2007-09-05 | Ethicon Endo-Surgery, Inc. | Biopsy device |
US20070208272A1 (en) * | 2006-03-03 | 2007-09-06 | Voegele James W | Biopsy device |
US7766843B2 (en) | 2006-03-03 | 2010-08-03 | Ethicon Endo-Surgery, Inc. | Biopsy method |
US9060759B2 (en) | 2011-03-31 | 2015-06-23 | Cook Medical Technologies Llc | Adjustable-throw biopsy needle |
US10092276B2 (en) | 2013-03-15 | 2018-10-09 | Cook Medical Technologies Llc | Tissue acquisition device with indication system |
Also Published As
Publication number | Publication date |
---|---|
CA2499993A1 (en) | 2004-04-01 |
WO2004026142B1 (en) | 2004-04-29 |
WO2004026142A1 (en) | 2004-04-01 |
US6890309B2 (en) | 2005-05-10 |
US20050090765A1 (en) | 2005-04-28 |
EP1542592A1 (en) | 2005-06-22 |
US6872185B2 (en) | 2005-03-29 |
US6709408B2 (en) | 2004-03-23 |
US20030236471A1 (en) | 2003-12-25 |
US20040167433A1 (en) | 2004-08-26 |
US20040167435A1 (en) | 2004-08-26 |
US6908440B2 (en) | 2005-06-21 |
EP1542592A4 (en) | 2009-06-03 |
CA2499993C (en) | 2013-08-06 |
AU2003267265A1 (en) | 2004-04-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6908440B2 (en) | Dual action aspiration biopsy needle | |
EP0808129B1 (en) | Device for automated biopsy and collection of soft tissue | |
US6019733A (en) | Biopsy apparatus and method | |
US6050955A (en) | Biopsy apparatus and method | |
US20060144548A1 (en) | Method of manufacturing a needle assembly for use with a biopsy device | |
US20050113716A1 (en) | Biopsy device having endoscope | |
US9381001B2 (en) | Tissue splitting biopsy needle | |
EP3045118A1 (en) | Exchangable core biopsy needle | |
US9301736B2 (en) | Fine needle biopsy with adaptor | |
US20150005662A1 (en) | System and method for fine needle aspiration | |
US20140100448A1 (en) | Rotary sample-collection needle | |
US20050070818A1 (en) | Biopsy device with viewing assembly | |
US7722548B2 (en) | Biopsy device | |
CN210903272U (en) | Interventional puncture device | |
US20100280408A1 (en) | Fine needle biopsy system and method of use | |
EP2595546B1 (en) | Aspiration incision biopsy needle | |
US20210298725A1 (en) | Rotatable tissue sampling device | |
US20030032895A1 (en) | Dual action aspiration biopsy needle | |
Leitão et al. | I. THE BASICS IN EUS-FNA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BIOPSY SCIENCES, LLC, FLORIDA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FISHER, JOHN S;REEL/FRAME:014494/0251 Effective date: 20040304 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
AS | Assignment |
Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., FLORIDA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BIOPSY SCIENCES, LLC;REEL/FRAME:019407/0830 Effective date: 20070122 |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
AS | Assignment |
Owner name: WELLS FARGO FOOTHILL, LLC AS AGENT, GEORGIA Free format text: SECURITY AGREEMENT;ASSIGNORS:ANGIOTECH PHARMACEUTICALS, INC.;AFMEDICA, INC.;AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC.;AND OTHERS;REEL/FRAME:022329/0310 Effective date: 20090227 Owner name: WELLS FARGO FOOTHILL, LLC AS AGENT,GEORGIA Free format text: SECURITY AGREEMENT;ASSIGNORS:ANGIOTECH PHARMACEUTICALS, INC.;AFMEDICA, INC.;AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC.;AND OTHERS;REEL/FRAME:022329/0310 Effective date: 20090227 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
AS | Assignment |
Owner name: GENERAL ELECTRIC CAPITAL CORPORATION, AS ADMINISTR Free format text: SECURITY AGREEMENT;ASSIGNORS:ARGON MEDICAL DEVICES, INC.;LUTHER MEDICAL PRODUCTS, INC.;MANAN MEDICAL PRODUCTS, INC.;AND OTHERS;REEL/FRAME:030208/0278 Effective date: 20130412 |
|
AS | Assignment |
Owner name: MANAN MEDICAL PRODUCTS, INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: ANGIOTECH PHARMACEUTICALS, INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: ANGIOTECH BIOCOATINGS CORP., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: AMERICAN MEDICAL INSTRUMENTS HOLDINGS, INC., CANAD Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: ANGIOTECH PHARMACEUTICALS (US), INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: QUILL MEDICAL, INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: ANGIOTECH INTERNATIONAL HOLDINGS CORP., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: SURGICAL SPECIALTIES CORPORATION, CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: ANGIOTECH AMERICA, INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: B.G. SULZLE, INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., CANADA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:DEUTSCHE BANK NATIONAL TRUST COMPANY;REEL/FRAME:030218/0820 Effective date: 20130412 |
|
FEPP | Fee payment procedure |
Free format text: PAT HOLDER NO LONGER CLAIMS SMALL ENTITY STATUS, ENTITY STATUS SET TO UNDISCOUNTED (ORIGINAL EVENT CODE: STOL); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
AS | Assignment |
Owner name: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRA Free format text: FIRST LIEN PATENT SECURITY AGREEMENT;ASSIGNOR:MEDICAL DEVICE TECHNOLOGIES, INC.;REEL/FRAME:037702/0580 Effective date: 20151223 |
|
AS | Assignment |
Owner name: HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRA Free format text: SECOND LIEN PATENT SECURITY AGREEMENT;ASSIGNOR:MEDICAL DEVICE TECHNOLOGIES, INC.;REEL/FRAME:037827/0764 Effective date: 20151223 |
|
AS | Assignment |
Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., ILLINOIS Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:GENERAL ELECTRIC COMPANY (AS SUCCESSOR IN INTEREST BY MERGER TO GENERAL ELECTRIC CAPITAL CORPORATION), AS ADMINISTRATIVE AGENT;REEL/FRAME:037756/0341 Effective date: 20151223 |
|
FPAY | Fee payment |
Year of fee payment: 12 |
|
AS | Assignment |
Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0706 Effective date: 20180123 Owner name: ARGON MEDICAL DEVICES, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0706 Effective date: 20180123 Owner name: MANAN MEDICAL PRODUCTS, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0706 Effective date: 20180123 Owner name: LUTHER MEDICAL PRODUCTS, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0706 Effective date: 20180123 Owner name: MANAN MEDICAL PRODUCTS, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0525 Effective date: 20180123 Owner name: PROMEX TECHNOLOGIES, LLC, ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0706 Effective date: 20180123 Owner name: PROMEX TECHNOLOGIES, LLC, ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0525 Effective date: 20180123 Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0525 Effective date: 20180123 Owner name: ARGON MEDICAL DEVICES, INC., ILLINOIS Free format text: RELEASE OF FIRST LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037703/0001, 037702/0592, 037702/0580, AND 037702/0497;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0525 Effective date: 20180123 Owner name: PROMEX TECHNOLOGIES, LLC, ILLINOIS Free format text: RELEASE OF SECOND LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037827/0460, 037827/0526, 037827/0764, AND 037827/0882;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0906 Effective date: 20180123 Owner name: ARGON MEDICAL DEVICES, INC., ILLINOIS Free format text: RELEASE OF SECOND LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037827/0460, 037827/0526, 037827/0764, AND 037827/0882;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0906 Effective date: 20180123 Owner name: LUTHER MEDICAL PRODUCTS, INC., ILLINOIS Free format text: RELEASE OF SECOND LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037827/0460, 037827/0526, 037827/0764, AND 037827/0882;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0906 Effective date: 20180123 Owner name: MANAN MEDICAL PRODUCTS, INC., ILLINOIS Free format text: RELEASE OF SECOND LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037827/0460, 037827/0526, 037827/0764, AND 037827/0882;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0906 Effective date: 20180123 Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., ILLINOIS Free format text: RELEASE OF SECOND LIEN PATENT SECURITY AGREEMENTS RECORDED AT REEL/FRAME 037827/0460, 037827/0526, 037827/0764, AND 037827/0882;ASSIGNOR:HEALTHCARE FINANCIAL SOLUTIONS, LLC, AS ADMINISTRATIVE AGENT;REEL/FRAME:045130/0906 Effective date: 20180123 |
|
AS | Assignment |
Owner name: UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT, CONNECTICUT Free format text: SECOND LIEN PATENT SECURITY AGREEMENT;ASSIGNORS:ARGON MEDICAL DEVICES, INC.;MEDICAL DEVICE TECHNOLOGIES, INC.;MANAN MEDICAL PRODUCTS, INC.;REEL/FRAME:046127/0602 Effective date: 20180123 Owner name: UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT, CONNECTICUT Free format text: FIRST LIEN PATENT SECURITY AGREEMENT;ASSIGNORS:ARGON MEDICAL DEVICES, INC.;MEDICAL DEVICE TECHNOLOGIES, INC.;MANAN MEDICAL PRODUCTS, INC.;REEL/FRAME:046127/0748 Effective date: 20180123 Owner name: UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT, CONN Free format text: SECOND LIEN PATENT SECURITY AGREEMENT;ASSIGNORS:ARGON MEDICAL DEVICES, INC.;MEDICAL DEVICE TECHNOLOGIES, INC.;MANAN MEDICAL PRODUCTS, INC.;REEL/FRAME:046127/0602 Effective date: 20180123 Owner name: UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT, CONN Free format text: FIRST LIEN PATENT SECURITY AGREEMENT;ASSIGNORS:ARGON MEDICAL DEVICES, INC.;MEDICAL DEVICE TECHNOLOGIES, INC.;MANAN MEDICAL PRODUCTS, INC.;REEL/FRAME:046127/0748 Effective date: 20180123 |
|
AS | Assignment |
Owner name: ARGON MEDICAL DEVICES, INC., ILLINOIS Free format text: TERMINATION AND RELEASE OF SECOND LIEN SECURITY INTEREST IN PATENTS;ASSIGNOR:UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT;REEL/FRAME:050375/0620 Effective date: 20190912 Owner name: MANAN MEDICAL PRODUCTS, INC., ILLINOIS Free format text: TERMINATION AND RELEASE OF FIRST LIEN SECURITY INTEREST IN PATENTS;ASSIGNOR:UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT;REEL/FRAME:050375/0599 Effective date: 20190912 Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., ILLINOIS Free format text: TERMINATION AND RELEASE OF FIRST LIEN SECURITY INTEREST IN PATENTS;ASSIGNOR:UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT;REEL/FRAME:050375/0599 Effective date: 20190912 Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., ILLINOIS Free format text: TERMINATION AND RELEASE OF SECOND LIEN SECURITY INTEREST IN PATENTS;ASSIGNOR:UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT;REEL/FRAME:050375/0620 Effective date: 20190912 Owner name: MANAN MEDICAL PRODUCTS, INC., ILLINOIS Free format text: TERMINATION AND RELEASE OF SECOND LIEN SECURITY INTEREST IN PATENTS;ASSIGNOR:UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT;REEL/FRAME:050375/0620 Effective date: 20190912 Owner name: ARGON MEDICAL DEVICES, INC., ILLINOIS Free format text: TERMINATION AND RELEASE OF FIRST LIEN SECURITY INTEREST IN PATENTS;ASSIGNOR:UBS AG, STAMFORD BRANCH, AS COLLATERAL AGENT;REEL/FRAME:050375/0599 Effective date: 20190912 |
|
AS | Assignment |
Owner name: ARGON MEDICAL DEVICES, INC., TEXAS Free format text: CHANGE OF OWNER/ASSIGNEE ADDRESS;ASSIGNOR:ARGON MEDICAL DEVICES, INC.;REEL/FRAME:062437/0600 Effective date: 20230119 |
|
AS | Assignment |
Owner name: HSBC BANK USA, NATIONAL ASSOCIATION, AS COLLATERAL AGENT, NEW YORK Free format text: SECURITY INTEREST;ASSIGNORS:ARGON MEDICAL DEVICES, INC.;MEDICAL DEVICE TECHNOLOGIES, INC.;MANAN MEDICAL PRODUCTS, INC.;REEL/FRAME:065612/0206 Effective date: 20190912 |
|
AS | Assignment |
Owner name: MANAN MEDICAL PRODUCTS, INC., TEXAS Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:HSBC BANK USA, NATIONAL ASSOCIATION, AS COLLATERAL AGENT;REEL/FRAME:066883/0812 Effective date: 20240318 Owner name: MEDICAL DEVICE TECHNOLOGIES, INC., TEXAS Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:HSBC BANK USA, NATIONAL ASSOCIATION, AS COLLATERAL AGENT;REEL/FRAME:066883/0812 Effective date: 20240318 Owner name: ARGON MEDICAL DEVICES, INC., TEXAS Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:HSBC BANK USA, NATIONAL ASSOCIATION, AS COLLATERAL AGENT;REEL/FRAME:066883/0812 Effective date: 20240318 |