US20040143247A1 - Method and apparatus for treating wrinkles in skin using radiation - Google Patents

Method and apparatus for treating wrinkles in skin using radiation Download PDF

Info

Publication number
US20040143247A1
US20040143247A1 US10/698,970 US69897003A US2004143247A1 US 20040143247 A1 US20040143247 A1 US 20040143247A1 US 69897003 A US69897003 A US 69897003A US 2004143247 A1 US2004143247 A1 US 2004143247A1
Authority
US
United States
Prior art keywords
skin
radiation
beam
region
dermal region
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/698,970
Inventor
R. Anderson
Edward Ross
James Hsia
Kathleen McMillan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Candela Corp
Original Assignee
General Hospital Corp
US Secretary of Navy
Candela Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US08/794,876 priority Critical patent/US5810801A/en
Priority to US09/153,052 priority patent/US6120497A/en
Priority to US09/587,156 priority patent/US6659999B1/en
Application filed by General Hospital Corp, US Secretary of Navy, Candela Corp filed Critical General Hospital Corp
Priority to US10/698,970 priority patent/US20040143247A1/en
Publication of US20040143247A1 publication Critical patent/US20040143247A1/en
Assigned to GENERAL HOSPITAL CORPORTATION reassignment GENERAL HOSPITAL CORPORTATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ANDERSON, R. ROX
Assigned to CANDELA CORPORATION reassignment CANDELA CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HSIA, JAMES C., MCMILLAN, KATHLEEN
Assigned to NAVY, UNITED STATES OF AMERICA, THE, AS REPRESENTED BY THE SECRETARY reassignment NAVY, UNITED STATES OF AMERICA, THE, AS REPRESENTED BY THE SECRETARY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ROSS, JR., EDWARD V.
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25163957&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20040143247(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Assigned to CANDELA CORPORATION reassignment CANDELA CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/203Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser applying laser energy to the outside of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00761Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00023Cooling or heating of the probe or tissue immediately surrounding the probe with fluids closed, i.e. without wound contact by the fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A61B2018/00029Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00452Skin
    • A61B2018/0047Upper parts of the skin, e.g. skin peeling or treatment of wrinkles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N2005/067Radiation therapy using light using laser light

Abstract

A method for treating wrinkles in skin involves the use of a beam of pulsed, scanned or gated continuous wave laser or incoherent radiation. The method comprises generating a beam of radiation, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring collagen in the targeted dermal region. The beam of radiation has a wavelength of between 1.3 and 1.8 microns. The method may include cooling an area of the skin above the targeted dermal region while partially denaturing the collagen in the targeted dermal region. The method may also include cooling an area of the skin above the targeted dermal region prior to thermally injuring collagen in the targeted dermal region.

Description

    FIELD OF THE INVENTION
  • The invention relates generally to the treatment of wrinkles in human skin using radiation. In particular, the invention relates to a method for treating wrinkles in human skin using a beam of laser or incoherent radiation to cause thermal injury in the dermal region of the skin sufficient to elicit a healing response that produces substantially unwrinkled skin. [0001]
  • BACKGROUND OF THE INVENTION
  • Undesired wrinkles in skin are commonly seen in dermatologic practice. Wrinkles in skin may be caused by age and by exposure to the sun's ultraviolet rays. Human skin consists mainly of two layers: the top layer of skin known as the epidermis; and the layer beneath the epidermis known as the dermis. The dermis is primarily acellular and is composed of water, the protein collagen, and glycosaminoglycans. Water constitutes approximately 70 percent of the total weight of the dermis. Collagen constitutes approximately 70 percent of the dry weight of the dermis, and glycosaminoglycans constitute between approximately 0.1 and 0.3 percent of the dry weight of the dermis. Collagen and glycosaminoglycans are constantly produced by fibroblasts, a type of connective tissue cell, and degraded by enzymes. Collagen degradation relies primarily on specific proteinases known as collagenases. [0002]
  • Collagen provides the dermis with the majority of its structural integrity. With aging, the amount of dermal collagen decreases and is replaced by the protein elastin. In addition, the remaining collagen tends to be chaotically oriented as compared to the more organized patterns found in youthful skin. Glycosaminoglycans are very hydrophilic, and increased amounts of these carbohydrates are associated with the increased skin vigor found in youthful skin. One major difference between the smooth, supple skin of newborns and the drier, thinned skin of older individuals is the far greater relative amount of glycosaminoglycans found in newborn skin. The glycosaminoglycans found in newborns can bind up to 1000 times their weight in water. As the skin ages and the amount of glycosaminoglycans decreases, the skin may become less hydrated and lose some of the suppleness found in youth. Also, the remaining glycosaminoglycans in photo-aged skin are deposited on the haphazardly arranged elastin fibers which have replaced the collagen fibers. The placement of the remaining glycosaminoglycans may partially account for the weather-beaten appearance of photo-aged skin. [0003]
  • Existing procedures for eliminating or reducing the severity of wrinkles include chemical peels, mechanical abrasion and laser ablation. All of these methods remove the top layer of skin. A new top layer forms during healing. Cosmetic improvement is seen when the skin containing wrinkles is replaced by a new layer of horizontally oriented neocollagen in the superficial dermis. However, all of these methods disrupt and completely remove the epidermis. The resulting open wounds require daily care to optimize wound healing. Epidermal destruction and subsequent healing has several undesirable side effects. These undesirable side effects include prolonged hypopigmentation, hyperpigmentation, erythema and edema. Hyperpigmentation occurs frequently in darker skin types as a result of an inflammatory response of the skin. Hyperpigmentation results in the treated area of the subject's skin turning darker than the surrounding untreated skin. Hyperpigmentation can be slow to clear, sometimes taking up to a year to disappear. Hypopigmentation is attributable to damage to the melanin-producing cells in the skin. While generally transient, hypopigmentation can be permanent, and is cosmetically undesirable while it persists. Also, erythema or redness of the skin may be significant for weeks to months after the procedure, requiring the patients to wear conspicuous amounts of make-up. [0004]
  • A known property of collagen fibers, such as those found in the skin, is that the fibers shrink when elevated to a temperature in the range of 60 to 70 degrees Celsius, which is about 30 degrees Celsius above normal body temperature. Temperature elevation ruptures the collagen ultrastructural stabilizing cross-links, and results in immediate contraction in the collagen fibers to about one-third of their original length without changing the structural integrity of the fibers. One known technique shrinks the collagen fibers in the cornea of the eye to change the shape of the cornea and correct refractive disorders. This technique involves the use of laser energy in a wavelength range of about 1.80 to about 2.55 microns. The laser energy is used to irradiate the collagen in the cornea to elevate the collagen to at least 23 degrees Celsius above normal body temperature and thereby achieve collagen shrinkage. U.S. Pat. Nos. 4,976,709, 5,137,530, 5,304,169, 5,374,265, and 5,484,432 to Sand disclose a technique and apparatus for controlled thermal shrinkage of collagen fibers in the cornea. [0005]
  • However, this technique cannot be effectively used to remove wrinkles in skin by shrinking dermal collagen. The bulk of the shrunken, thermally denatured, collagen fibers do not remain in the skin after treatment with this technique. Unlike the cornea, which is avascular, an aggressive healing response in the skin degrades the denatured collagen in the superficial dermis by collagenases, thereby rapidly eliminating the bulk of the shrunken collagen from the skin. [0006]
  • Additionally, in the 1.80 to 2.55 micron wavelength range, strong absorption of the laser energy by water present in the skin limits the penetration depth of the laser radiation to a small fraction of a millimeter. The depths of thermal injury which can be achieved in skin using the wavelengths in this range are therefore limited to the most superficial layer of the skin. Such superficial injury leads to an inflammatory healing response characterized by prolonged visible edema and erythema, as well as the possibility for long lasting pigmentary disturbances. [0007]
  • SUMMARY OF THE INVENTION
  • The present invention addresses the foregoing problems and provides a method for inducing remodeling of the skin's extracellular matrix by partially denaturing the dermal collagen deeper in the skin, below the surface, while avoiding injury to the epidermis and upper layers of the dermis. The invention offers numerous advantages over existing dermatologic procedures and devices. The surface of the skin remains intact, thereby avoiding the need for dressing wounds; pigmentary disturbances are minimized; and any inflammatory response to the injury is mild and less visually evident. [0008]
  • In general, the present invention features a method for treating wrinkles in skin, without removing a layer of skin, using a beam of pulsed, scanned or gated continuous wave (CW) laser or incoherent radiation. The method comprises generating a beam of radiation having a wavelength between 1.3 and 1.8 microns, directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, and thermally injuring the targeted dermal region to elicit a healing response that produces substantially less wrinkles. [0009]
  • More specifically, causing selective thermal injury to the dermis activates fibroblasts which deposit increased amounts of extracellular matrix constituents (i.e., collagen and glycosaminoglycans). These increases in extracellular matrix constituents are responsible for dermal skin rejuvenation and the reduced appearance of wrinkles. [0010]
  • In one embodiment, the beam of radiation causes partial denaturation of the collagen in the targeted dermal region. The partial denaturation of the collagen accelerates the collagen synthesis process by the fibroblasts and the deposition of new glycosaminoglycans, leading to the elimination or a reduction in the severity of the wrinkle. The method may also include cooling the surface of the skin and epidermal tissue above the targeted dermal region while irradiating the skin. The method may also include cooling the surface of the skin prior to irradiating the skin. [0011]
  • In a detailed embodiment, the method also includes stretching the skin along the wrinkle before directing the beam of radiation to the targeted dermal region below the wrinkle. Stretching the skin causes thermal injury to the collagen fibers across the wrinkle, while not affecting the fibers along the wrinkle. [0012]
  • The invention also relates to an apparatus for treating wrinkles in skin. The apparatus includes a radiation source and a delivery system which includes a cooling system. The radiation source generates a beam of radiation having a wavelength between 1.3 and 1.8 microns. The delivery system directs the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin. The cooling system cools the epidermal tissue above the targeted dermal region to minimize injury to the surface of the skin.[0013]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • The foregoing and other objects, features and advantages of the invention will become apparent from the following more particular description of preferred embodiments of the invention, as illustrated in the accompanying drawings. The drawings are not necessarily to scale, emphasis instead being placed on illustrating the principles of the present invention. [0014]
  • FIG. 1 is an illustration of an apparatus including a radiation source and a delivery system for practicing the invention. [0015]
  • FIG. 2 is an enlarged perspective view of a delivery system incorporating the principles of the invention. [0016]
  • FIG. 3 is an illustration of a wrinkle in skin exposed to a plurality of radiation pulses. [0017]
  • FIG. 4 is an illustration of a region of skin exposed to a highly convergent beam of radiation.[0018]
  • DETAILED DESCRIPTION OF THE INVENTION
  • The present invention contemplates a system and method for removing wrinkles which includes delivering a beam of laser or incoherent radiation to cause sufficient thermal injury in the dermal region of the skin to elicit a healing response to cause the skin to remodel itself, resulting in more youthful looking (i.e., substantially unwrinkled) skin. In particular, thermal injury may be in the form of partial denaturation of the collagen fibers in the targeted dermal region of skin. In one embodiment, the radiation beam has a set of parameter ranges carefully selected to partially denature collagen in the dermis while protecting the epidermis by surface cooling. As a result, a subject treated using the method of the invention is able to have the appearance of wrinkles lessened without damage to the epidermis. [0019]
  • FIG. 1 is an illustration of a system [0020] 10 for practicing the invention. The system 10 includes a radiation source 12 and a delivery system 13. A beam of radiation generated by the radiation source 12 is directed to a target region of a subject's skin including a wrinkle via the delivery system 13. In one embodiment, the radiation source 12 is a laser. The laser may generate a beam of pulsed, scanned or gated CW laser radiation. In another embodiment, the radiation source 12 generates incoherent radiation.
  • The beam of radiation is directed to a targeted dermal region of skin between 100 microns and 1.2 millimeters below the wrinkle. The parameter ranges for the beam have been specifically selected to cause thermal injury to the dermis while avoiding injury to the epidermis and upper layers of the dermis. In particular, the wavelength of the radiation beam has been chosen to maximize absorption in the targeted region of the dermis, and the fluence or power density, depending on the type of radiation, has been chosen to minimize erythema. The wavelength range chosen has a tissue absorption coefficient preferably in the range of about 1 to 20 cm[0021] −1. Thus, the beam preferably has a wavelength of between about 1.3 and 1.8 microns in one embodiment. Within this wavelength range, radiation energy applied through the surface of the skin is deposited predominantly in the dermal region of the skin. In one embodiment, the radiation beam has a nominal wavelength of approximately 1.5 microns. Lasers which produce radiation having wavelengths in the range of between about 1.3 and 1.8 microns include the 1.33 micron Nd:YAG laser, the 1.44 micron Nd:YAG laser and the 1.54 micron Er:Glass laser. The radiation beam may be pulsed, scanned or gated continuous wave laser radiation. In embodiments having a laser as the radiation source 12, the laser radiation generated preferably has a fluence of between about 10 and 150 joules.
  • In another embodiment, the radiation used to thermally injure the dermis is incoherent radiation. In embodiments using incoherent radiation, the incoherent radiation generated by the radiation source [0022] 12 preferably has a power density of between about 5 and 100 watts per square centimeter.
  • FIG. 2 is an enlarged perspective view of a delivery system [0023] 13 incorporating the principles of the invention. The delivery system 13 includes a fiber 14 having a circular cross-section and a handpiece 16. A beam of radiation having a circular cross-section is delivered by the fiber 14 to the handpiece 16. An optical system within the handpiece 16 projects an output beam of radiation to a targeted region of the subject's skin. A user holding the handpiece 16 irradiates the targeted region of the subject's skin including the wrinkle with output pulses from the beam.
  • To minimize thermal injury to the epidermis and the upper layers of the dermis, in one embodiment, the delivery system [0024] 13 includes a cooling system for cooling the surface of the skin prior to and/or during application of the radiation. In this embodiment, the delivery system 13 is multi-functional and is capable of delivering radiation and cooling the surface of the skin at the same time. FIG. 3 shows one embodiment of a delivery system 13 which includes a cooling system. The handpiece 16 includes a skin contacting portion 20 which is brought into contact with the region of skin 22 receiving the beam of radiation 24. The skin contacting portion 20 cools the epidermal region of skin 22 receiving the beam of radiation. The skin contacting portion 20 includes a sapphire window 26 and a fluid passage 28 which contains a cooling fluid. The cooling fluid may be a fluorocarbon type cooling fluid. The cooling fluid circulates through the fluid passage 28 and past the sapphire window 26 which is in contact with the epidermal region of skin 22 receiving the beam of radiation 24.
  • In another embodiment, the delivery system [0025] 13 and the cooling system are separate systems. The cooling system may comprise a container of a cold fluid. Cooling of the surface of the skin is accomplished by briefly spraying the skin with the cold fluid which extracts heat from the skin on contact. The fluid used can also be a non-toxic substance with high vapor pressure at normal body temperature, such as a freon. These fluids extract heat from the skin by the virtue of evaporative cooling.
  • FIG. 3 illustrates the treatment of a wrinkle [0026] 30 in accordance with the invention. Radiation pulses are produced using the radiation source 12, which may be a pulsed, scanned or gated CW laser or incoherent radiation source. The radiation pulses are directed toward the region 22 of the subject's skin containing the wrinkle 30 by the delivery system 13. The radiation pulses are preferably directed to a targeted dermal region between 100 microns and 1.2 millimeters below the surface of the skin. In a detailed embodiment, the radiation pulses are focused to a region centered at a depth of about 750 microns. The targeted dermal region including a portion of the wrinkle 30 is then irradiated with radiation pulses exiting from the handpiece 16 until collagen in that region is partially denatured. To accomplish this, the collagen at the selected depth in the targeted dermal region is preferably heated to a temperature in the range of about 50 to 70 degrees Celsius. Partially denaturing collagen in the dermis accelerates the collagen synthesis process by the fibroblasts. The thermal injury caused by the radiation is mild and is only sufficient to elicit a healing response and cause the fibroblasts to produce new collagen. Excessive denaturation of collagen in the dermis causes prolonged edema, erythema, and potentially scarring.
  • The skin contacting portion [0027] 20 preferably cools the area of the skin above the targeted dermal region to temperatures below approximately 50 to 70 degrees Celsius during application of the radiation, so as not to cause collateral thermal damage to the epidermis. The radiation beam, due to its wavelength, does not sufficiently penetrate into depths below the targeted dermal region to cause thermal damage deeper in the skin. In one detailed embodiment, the skin contacting portion 20 cools an area of the skin above the targeted dermal region before the radiation is applied. The relative timing of cooling the surface of the skin to applying radiation depends, in part, on the depth to which thermal injury is to be prevented. Longer periods of cooling prior to the application of radiation allow more time for heat to diffuse out of the skin and cause a thicker layer of skin to be cooled, as compared to the thickness of the layer cooled by a short period of cooling. This thicker layer of cooled tissue sustains less thermal injury when the radiation energy is subsequently applied. Continued cooling of the surface of the skin during the delivery of radiation energy extracts heat from the upper layers of the skin as heat is deposited by the radiation, thereby further protecting the upper layers from thermal injury.
  • The depth of thermal injury caused by the radiation depends primarily on the penetration depth of the radiation used. The penetration depth can be approximated by taking the reciprocal of the absorption coefficient of the skin at the wavelength of the radiation. The thickness of the tissue overlying the zone of injury which is spared from injury depends primarily on the cooling applied prior to and/or during the delivery of radiation energy. By suitably choosing the radiation wavelength, the timing of the surface cooling, the cooling temperature, the radiation fluence and/or the power density as described above, the depth, the thickness and the degree of thermal injury can be confined to a zone within the dermis. These parameters can be chosen to optimally induce the injury required to elicit remodeling within the dermis, while substantially or completely sparing injury to the overlying epidermis and upper layers of the dermis. [0028]
  • In another detailed embodiment, the region of skin including the wrinkle [0029] 30 is stretched along the wrinkle 30 before the beam of radiation is directed to the targeted dermal region below the wrinkle 30. Stretching the skin along the wrinkle before irradiating the skin causes partial denaturation of the collagen fibers across the wrinkle, while not damaging the fibers along the wrinkle. Partially denaturing the fibers across the wrinkle tightens the skin sufficiently to cause the wrinkle to disappear.
  • Referring to FIG. 4, in one embodiment, to counteract the effects of scattering, the radiation beam is made highly convergent on the surface of the skin. [0030]
  • Experimental Results [0031]
  • The method of the present invention for treating wrinkles in skin using radiation was applied in a series of in vivo experiments performed on pigs. A pulsed erbium glass laser producing radiation having a wavelength of approximately 1.54 microns was used as the radiation source [0032] 12. The laser energy was applied to the pig skin via the skin contacting portion 20 equipped with a cooled sapphire window 26 at the tip, as described above and shown in FIGS. 1-3. The inner surface of the sapphire window 26 was cooled by circulating refrigerated coolant, chilled to approximately minus 25 degrees Celsius through the passage 28. The coolant used was a halocarbon which is transparent to the 1.54 micron laser radiation. The laser beam at the outer surface of the sapphire window 26 was approximately 5 mm in diameter.
  • The tip of the skin contacting portion [0033] 20 was placed in contact with the skin to cool the skin prior to applying the laser radiation. After a set amount of time (hereinafter “the pre-cooling time”), laser energy was applied to the skin. Various combinations of pre-cooling times, laser pulse energies, laser pulse repetition frequencies, time intervals of laser energy delivery, and total number of laser pulses delivered were studied. It was found that by the appropriate choice of these parameters, varying degrees of thermal injury can be achieved at varying depths in the dermis while preserving the viability of the epidermis and upper dermis.
  • For example, using a pre-cooling time of 5 seconds, a laser energy in the range of between 0.2 and 0.8 joules per pulse at a pulse repetition frequency of 4 Hertz (corresponding to an average laser power in the range between 0.8 to 3.2 watts), and a total of 24 pulses, it was found that varying degrees of thermal injury could be induced in a zone centered at a depth in the range of approximately 0.5 to 1.0 millimeters beneath the surface of the skin, while avoiding injury to the epidermis and upper dermis. [0034]
  • Histology performed on biopsy samples taken at sites treated with the above range of parameters revealed collagen denaturation extending from about 100 microns in the dermis to about 1 mm deep. The epidermis and upper layers of the dermis were preserved as confirmed with nitrotetrazolium blue, a viability stain. In the cases in which only partial collagen denaturation was shown on histology, clinically, the treated areas showed an intact epidermis with mild edema and erythema which resolved completely within two weeks. Histologically, the treated sites showed greatly increased fibroblast activity, new collagen secretion and degradation of denatured collagen. By four weeks post treatment, the treated sites returned to normal, both clinically and histologically. [0035]
  • Equivalents [0036]
  • While the invention has been particularly shown and described with reference to specific embodiments, it should be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. [0037]

Claims (15)

What is claimed is:
1. A method for treating a wrinkle in human skin, comprising:
generating a beam of radiation having a wavelength of between 1.3 and 1.8 microns and a fluence of between 10 and 150 joulesper square centimeter;
directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin; and
causing thermal injury within the targeted dermal region to elicit a healing response that produces substantially unwrinkled skin.
2. The method of claim 1 wherein the wavelength is about 1.5 microns.
3. The method of claim 1 further comprising the step of stretching the skin along the wrinkle before the step of directing the beam of radiation to the targeted dermal region.
4. The method of claim 1 further comprising the step of cooling an epidermal region of the skin above the targeted dermal region contemporaneously with the step of causing thermal injury within the targeted dermal region.
5. The method of claim 4 further comprising the step of pre-cooling the epidermal region of the skin above the targeted dermal region before the step of causing thermal injury within the targeted dermal region.
6. A method for treating a wrinkle in human skin, comprising:
generating a beam of radiation having a wavelength of between 1.3 and 1.8 microns and a power density of between 5 and 100 watts per square centimeter;
directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin; and
causing thermal injury within the targeted dermal region to elicit a healing response that produces substantially unwrinkled skin.
7. The method of claim 6 wherein the wavelength is about 1.5 microns.
8. The method of claim 6 further comprising the step of stretching the skin along the wrinkle before the step of directing the beam of radiation to the targeted dermal region.
9. The method of claim 6 further comprising the step of cooling an epidermal region of the skin above the targeted dermal region contemporaneously with the step of causing thermal injury within the targeted dermal region.
10. The method of claim 9 further comprising the step of pre-cooling the epidermal region of the skin above the targeted dermal region before the step of causing thermal injury within the targeted dermal region.
11. An apparatus for treating a wrinkle in human skin, comprising:
a source generating a beam of radiation having a wavelength of between 1.3 and 1.8 microns; and
a delivery system coupled to the source, the delivery system directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeters below a wrinkle in the skin, wherein the beam of radiation causes thermal injury to the targeted dermal region sufficient to elicit a healing response that produces substantially unwrinkled skin, the delivery system further comprising:
a cooling system for contact cooling an epidermal region of the skin above the targeted dermal region, to thereby minimize injury to the epidermal region.
12. The apparatus of claim 11 wherein the delivery system further comprises a fiber coupled to the source, the fiber carrying the beam of radiation; and
wherein the cooling system further comprises a skin contacting portion having a first end in optical communication with the fiber and a second end, the skin contacting portion projecting the beam of radiation toward the targeted dermal region through the second end of the skin contacting portion.
13. The apparatus of claim 12 wherein the skin contacting portion further comprises a window located at the second end of the skin contacting portion, the window being in optical communication with the fiber; and
wherein the skin contacting portion has a fluid passage extending across at least a portion of the window, the fluid passage circulating a cooling fluid past the window.
14. An apparatus for treating a wrinkle in human skin, comprising:
a source generating a beam of radiation having a wavelength of between 1.3 and 1.8 microns;
a delivery system coupled to the source, the delivery system directing the beam of radiation to a targeted dermal region between 100 microns and 1.2 millimeter, below a wrinkle in the skin, wherein the beam of radiation causes thermal injury to the targeted dermal region sufficient to elicit a healing response that produces substantially unwrinkled skin; and
a cooling system for cooling an epidermal region of the skin above the targeted dermal region, to thereby minimize injury to the epidermal region.
15. The apparatus of claim 14 wherein the cooling system comprises a container of cold fluid, wherein the cold fluid is sprayed onto the skin and extracts heat from the skin on contact.
US10/698,970 1997-02-05 2003-10-31 Method and apparatus for treating wrinkles in skin using radiation Abandoned US20040143247A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US08/794,876 US5810801A (en) 1997-02-05 1997-02-05 Method and apparatus for treating wrinkles in skin using radiation
US09/153,052 US6120497A (en) 1997-02-05 1998-09-15 Method and apparatus for treating wrinkles in skin using radiation
US09/587,156 US6659999B1 (en) 1997-02-05 2000-06-05 Method and apparatus for treating wrinkles in skin using radiation
US10/698,970 US20040143247A1 (en) 1997-02-05 2003-10-31 Method and apparatus for treating wrinkles in skin using radiation

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/698,970 US20040143247A1 (en) 1997-02-05 2003-10-31 Method and apparatus for treating wrinkles in skin using radiation
US11/148,051 US20050256515A1 (en) 1997-02-05 2005-06-08 Method and apparatus for treating wrinkles in skin using radiation
US12/167,720 US20080269733A1 (en) 1997-02-05 2008-07-03 Method and apparatus for treating wrinkles in skin using radiation

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/587,156 Continuation US6659999B1 (en) 1997-02-05 2000-06-05 Method and apparatus for treating wrinkles in skin using radiation

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/148,051 Continuation US20050256515A1 (en) 1997-02-05 2005-06-08 Method and apparatus for treating wrinkles in skin using radiation
US12/167,720 Continuation US20080269733A1 (en) 1997-02-05 2008-07-03 Method and apparatus for treating wrinkles in skin using radiation

Publications (1)

Publication Number Publication Date
US20040143247A1 true US20040143247A1 (en) 2004-07-22

Family

ID=25163957

Family Applications (6)

Application Number Title Priority Date Filing Date
US08/794,876 Expired - Fee Related US5810801A (en) 1997-02-05 1997-02-05 Method and apparatus for treating wrinkles in skin using radiation
US09/153,052 Expired - Lifetime US6120497A (en) 1997-02-05 1998-09-15 Method and apparatus for treating wrinkles in skin using radiation
US09/587,156 Expired - Fee Related US6659999B1 (en) 1997-02-05 2000-06-05 Method and apparatus for treating wrinkles in skin using radiation
US10/698,970 Abandoned US20040143247A1 (en) 1997-02-05 2003-10-31 Method and apparatus for treating wrinkles in skin using radiation
US11/148,051 Abandoned US20050256515A1 (en) 1997-02-05 2005-06-08 Method and apparatus for treating wrinkles in skin using radiation
US12/167,720 Abandoned US20080269733A1 (en) 1997-02-05 2008-07-03 Method and apparatus for treating wrinkles in skin using radiation

Family Applications Before (3)

Application Number Title Priority Date Filing Date
US08/794,876 Expired - Fee Related US5810801A (en) 1997-02-05 1997-02-05 Method and apparatus for treating wrinkles in skin using radiation
US09/153,052 Expired - Lifetime US6120497A (en) 1997-02-05 1998-09-15 Method and apparatus for treating wrinkles in skin using radiation
US09/587,156 Expired - Fee Related US6659999B1 (en) 1997-02-05 2000-06-05 Method and apparatus for treating wrinkles in skin using radiation

Family Applications After (2)

Application Number Title Priority Date Filing Date
US11/148,051 Abandoned US20050256515A1 (en) 1997-02-05 2005-06-08 Method and apparatus for treating wrinkles in skin using radiation
US12/167,720 Abandoned US20080269733A1 (en) 1997-02-05 2008-07-03 Method and apparatus for treating wrinkles in skin using radiation

Country Status (4)

Country Link
US (6) US5810801A (en)
EP (1) EP1011811B1 (en)
DE (1) DE69830732T2 (en)
WO (1) WO1998033558A1 (en)

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US20050049658A1 (en) * 2003-08-25 2005-03-03 Connors Kevin P. System and method for heating skin using light to provide tissue treatment
US20050143719A1 (en) * 2003-12-31 2005-06-30 Sink Robert K. Multi-spot laser surgical apparatus and method
US20050141068A1 (en) * 2003-12-31 2005-06-30 Debenedictis Leonard C. High speed, high efficiency optical pattern generator using rotating optical elements
US20050171581A1 (en) * 2003-08-25 2005-08-04 Connors Kevin P. System and method for heating skin using light to provide tissue treatment
US20050259306A1 (en) * 2003-12-31 2005-11-24 Broome Barry G Two-dimensional optical scan system using a counter-rotating disk scanner
US20050278002A1 (en) * 2004-06-14 2005-12-15 David Eimerl Adaptive control of optical pulses for laser medicine
US20060197247A1 (en) * 1998-02-12 2006-09-07 Moldflow Pty Ltd Automated Molding Technology For Thermoplastic Injection Molding
WO2006116141A1 (en) * 2005-04-22 2006-11-02 Cynosure, Inc. Methods and systems for laser treatment using non-uniform output beam
US20080161745A1 (en) * 2006-09-08 2008-07-03 Oliver Stumpp Bleaching of contrast enhancing agent applied to skin for use with a dermatological treatment system
US7891362B2 (en) 2005-12-23 2011-02-22 Candela Corporation Methods for treating pigmentary and vascular abnormalities in a dermal region
US8246611B2 (en) 2006-06-14 2012-08-21 Candela Corporation Treatment of skin by spatial modulation of thermal heating
US8277495B2 (en) 2005-01-13 2012-10-02 Candela Corporation Method and apparatus for treating a diseased nail
US8915906B2 (en) 2003-08-25 2014-12-23 Cutera, Inc. Method for treatment of post-partum abdominal skin redundancy or laxity
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US9028469B2 (en) 2005-09-28 2015-05-12 Candela Corporation Method of treating cellulite
US9351792B2 (en) 2003-03-27 2016-05-31 The General Hospital Corporation Method and apparatus for dermatological treatment and fractional skin resurfacing
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use

Families Citing this family (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3263275B2 (en) * 1994-04-05 2002-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Apparatus and flame-shaped spots nevi laser processing apparatus for laser treatment of biological tissue
US6248103B1 (en) 1994-04-05 2001-06-19 The Regents Of The University Of California Apparatus and method for dynamic cooling of biological tissues for thermal mediated surgery using long laser pulses
US7189230B2 (en) * 1996-01-05 2007-03-13 Thermage, Inc. Method for treating skin and underlying tissue
US7452358B2 (en) * 1996-01-05 2008-11-18 Thermage, Inc. RF electrode assembly for handpiece
US7229436B2 (en) 1996-01-05 2007-06-12 Thermage, Inc. Method and kit for treatment of tissue
US6106514A (en) * 1996-08-12 2000-08-22 O'donnell, Jr.; Francis E. Laser method for subsurface cutaneous treatment
US20080294152A1 (en) * 1996-12-02 2008-11-27 Palomar Medical Technologies, Inc. Cooling System For A Photocosmetic Device
US8182473B2 (en) 1999-01-08 2012-05-22 Palomar Medical Technologies Cooling system for a photocosmetic device
US5810801A (en) * 1997-02-05 1998-09-22 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
US6235015B1 (en) * 1997-05-14 2001-05-22 Applied Optronics Corporation Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
DE69926348T2 (en) 1998-03-12 2006-06-01 Palomar Medical Technologies, Inc., Burlington System for the electromagnetic irradiation of the skin
CN1872007A (en) * 2001-05-23 2006-12-06 帕洛玛医疗技术公司 Method for operating photocosmetic device and device for infliction electromagnetic ray to skin
US6517532B1 (en) 1997-05-15 2003-02-11 Palomar Medical Technologies, Inc. Light energy delivery head
JP4056091B2 (en) 1997-05-15 2008-03-05 ザ ジェネラル ホスピタル コーポレーション Dermatology treatment method and apparatus
CN102499755B (en) * 2001-05-23 2014-11-12 帕洛玛医疗技术公司 Cooling system for photocosmetic device
US5968034A (en) * 1997-06-24 1999-10-19 Laser Aesthetics, Inc. Pulsed filament lamp for dermatological treatment
US6104959A (en) 1997-07-31 2000-08-15 Microwave Medical Corp. Method and apparatus for treating subcutaneous histological features
US6273885B1 (en) * 1997-08-16 2001-08-14 Cooltouch Corporation Handheld photoepilation device and method
US6413253B1 (en) 1997-08-16 2002-07-02 Cooltouch Corporation Subsurface heating of material
US6074382A (en) 1997-08-29 2000-06-13 Asah Medico A/S Apparatus for tissue treatment
US20060184071A1 (en) * 1997-12-29 2006-08-17 Julia Therapeutics, Llc Treatment of skin with acoustic energy
US6113559A (en) * 1997-12-29 2000-09-05 Klopotek; Peter J. Method and apparatus for therapeutic treatment of skin with ultrasound
US20080027328A1 (en) * 1997-12-29 2008-01-31 Julia Therapeutics, Llc Multi-focal treatment of skin with acoustic energy
US20080146970A1 (en) * 2005-12-06 2008-06-19 Julia Therapeutics, Llc Gel dispensers for treatment of skin with acoustic energy
US6026816A (en) * 1998-01-22 2000-02-22 Candela Corporation Method of treating sleep-disordered breathing syndromes
ES2403359T3 (en) * 1998-03-27 2013-05-17 The General Hospital Corporation Method and apparatus for the selective determination of lipid-rich tissues
US6077294A (en) 1998-06-11 2000-06-20 Cynosure, Inc. Method for non-invasive wrinkle removal and skin treatment
US6595986B2 (en) 1998-10-15 2003-07-22 Stephen Almeida Multiple pulse photo-dermatological device
US6059820A (en) 1998-10-16 2000-05-09 Paradigm Medical Corporation Tissue cooling rod for laser surgery
USRE43881E1 (en) 1998-10-16 2012-12-25 Reliant Technologies, Inc. Tissue cooling rod for laser surgery
US6283956B1 (en) * 1998-11-30 2001-09-04 David H. McDaniels Reduction, elimination, or stimulation of hair growth
US6887260B1 (en) * 1998-11-30 2005-05-03 Light Bioscience, Llc Method and apparatus for acne treatment
US6936044B2 (en) * 1998-11-30 2005-08-30 Light Bioscience, Llc Method and apparatus for the stimulation of hair growth
US9192780B2 (en) 1998-11-30 2015-11-24 L'oreal Low intensity light therapy for treatment of retinal, macular, and visual pathway disorders
US20060212025A1 (en) * 1998-11-30 2006-09-21 Light Bioscience, Llc Method and apparatus for acne treatment
US6514242B1 (en) * 1998-12-03 2003-02-04 David Vasily Method and apparatus for laser removal of hair
US6402739B1 (en) 1998-12-08 2002-06-11 Y-Beam Technologies, Inc. Energy application with cooling
US6325769B1 (en) 1998-12-29 2001-12-04 Collapeutics, Llc Method and apparatus for therapeutic treatment of skin
US6200308B1 (en) 1999-01-29 2001-03-13 Candela Corporation Dynamic cooling of tissue for radiation treatment
WO2000053261A1 (en) 1999-03-08 2000-09-14 Asah Medico A/S An apparatus for tissue treatment and having a monitor for display of tissue features
US7022121B2 (en) * 1999-03-09 2006-04-04 Thermage, Inc. Handpiece for treatment of tissue
US7041094B2 (en) 1999-03-15 2006-05-09 Cutera, Inc. Tissue treatment device and method
GB9912877D0 (en) * 1999-06-04 1999-08-04 Sls Biophile Limited Tissue rejuvenation
US6451007B1 (en) * 1999-07-29 2002-09-17 Dale E. Koop Thermal quenching of tissue
US20080091179A1 (en) * 1999-12-10 2008-04-17 Candela Corporation Compact, handheld device for home-based acne treatment
US6743222B2 (en) * 1999-12-10 2004-06-01 Candela Corporation Method of treating disorders associated with sebaceous follicles
US20020091377A1 (en) * 2000-01-25 2002-07-11 Anderson R. Rox Method and apparatus for medical treatment utilizing long duration electromagnetic radiation
US6436094B1 (en) 2000-03-16 2002-08-20 Laserscope, Inc. Electromagnetic and laser treatment and cooling device
US6653618B2 (en) 2000-04-28 2003-11-25 Palomar Medical Technologies, Inc. Contact detecting method and apparatus for an optical radiation handpiece
US6702838B1 (en) 2000-09-18 2004-03-09 Lumenis Inc. Method of treating hypotrophic scars enlarged pores
US6702808B1 (en) 2000-09-28 2004-03-09 Syneron Medical Ltd. Device and method for treating skin
US6808532B2 (en) * 2000-12-15 2004-10-26 Dan E. Andersen Laser treatment for reducing wrinkles
GB2370229A (en) * 2000-12-22 2002-06-26 Icn Photonics Ltd Light delivery system for improving the appearance of skin
CN103251453A (en) * 2000-12-28 2013-08-21 帕洛玛医疗技术有限公司 Method and apparatus for EMR treatment of skin
AU2002316500A1 (en) 2001-07-02 2003-01-21 Palomar Medical Technologies, Inc. Laser device for medical/cosmetic procedures
US7094252B2 (en) * 2001-08-21 2006-08-22 Cooltouch Incorporated Enhanced noninvasive collagen remodeling
WO2003017826A2 (en) * 2001-08-27 2003-03-06 Regeneration Technologies, Inc. Processed soft tissue for topical or internal application
US20030069569A1 (en) 2001-08-29 2003-04-10 Burdette Everette C. Ultrasound device for treatment of intervertebral disc tissue
US7303578B2 (en) * 2001-11-01 2007-12-04 Photothera, Inc. Device and method for providing phototherapy to the brain
EP1455671B1 (en) 2001-12-10 2007-06-13 Inolase 2002 Ltd. Method and apparatus for improving safety during exposure to a monochromatic light source
EP1627662B1 (en) 2004-06-10 2011-03-02 Candela Corporation Apparatus for vacuum-assisted light-based treatments of the skin
US7762964B2 (en) * 2001-12-10 2010-07-27 Candela Corporation Method and apparatus for improving safety during exposure to a monochromatic light source
US7935139B2 (en) * 2001-12-10 2011-05-03 Candela Corporation Eye safe dermatological phototherapy
US7740600B2 (en) * 2002-08-02 2010-06-22 Candela Corporation Apparatus and method for inhibiting pain signals transmitted during a skin related medical treatment
US7762965B2 (en) * 2001-12-10 2010-07-27 Candela Corporation Method and apparatus for vacuum-assisted light-based treatments of the skin
US20030216719A1 (en) * 2001-12-12 2003-11-20 Len Debenedictis Method and apparatus for treating skin using patterns of optical energy
US20030109787A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser diagnostics
WO2003077783A1 (en) 2002-03-12 2003-09-25 Palomar Medical Technologies, Inc. Method and apparatus for hair growth management
US7259906B1 (en) 2002-09-03 2007-08-21 Cheetah Omni, Llc System and method for voice control of medical devices
US20040048842A1 (en) * 2002-09-10 2004-03-11 Mcmillan Kathleen Method of treating skin disorders
EP2522294A2 (en) 2002-10-23 2012-11-14 Palomar Medical Technologies, Inc. Phototreatment device for use with coolants and topical substances
CA2503880A1 (en) * 2002-10-31 2004-05-13 Cooltouch, Incorporated Endovenous closure of varicose veins with mid infrared laser
US20080021527A1 (en) * 2003-10-30 2008-01-24 Cooltouch Incorporated Endovenous laser treatment generating reduced blood coagulation
US8409183B2 (en) 2003-10-30 2013-04-02 Cooltouch Incorporated Endovenous laser treatment generating reduced blood coagulation
US7921854B2 (en) * 2002-10-31 2011-04-12 Cooltouch Incorporated Endovenous laser treatment for varicose veins
US7703458B2 (en) * 2003-02-21 2010-04-27 Cutera, Inc. Methods and devices for non-ablative laser treatment of dermatologic conditions
EP1596745B1 (en) 2003-02-25 2016-02-17 Tria Beauty, Inc. Self-contained, diode-laser-based dermatologic treatment apparatus
US7981111B2 (en) 2003-02-25 2011-07-19 Tria Beauty, Inc. Method and apparatus for the treatment of benign pigmented lesions
US7014639B2 (en) * 2003-02-25 2006-03-21 Skincare Technology, Inc. Apparatus for aesthetic skin treatments
EP2604215B1 (en) 2003-02-25 2017-10-11 Tria Beauty, Inc. Eye-safe dermatologic treatment apparatus and method
US8777935B2 (en) 2004-02-25 2014-07-15 Tria Beauty, Inc. Optical sensor and method for identifying the presence of skin
WO2004092335A2 (en) 2003-04-10 2004-10-28 Light Bioscience, Inc. Photomodulation methods and devices for regulating cell proliferation and gene expression
US20050015077A1 (en) * 2003-07-14 2005-01-20 Yevgeniy Kuklin Method and apparatus for skin treatment using near infrared laser radiation
US7291140B2 (en) 2003-07-18 2007-11-06 Cutera, Inc. System and method for low average power dermatologic light treatment device
JP4739202B2 (en) * 2003-07-31 2011-08-03 ジェントルウェイブス エルエルシー System and method for photodynamic treatment of burns, wounds, and related skin diseases
US7416549B2 (en) * 2003-10-10 2008-08-26 Boston Scientific Scimed, Inc. Multi-zone bipolar ablation probe assembly
US7326199B2 (en) 2003-12-22 2008-02-05 Cutera, Inc. System and method for flexible architecture for dermatologic treatments utilizing multiple light sources
US7282060B2 (en) 2003-12-23 2007-10-16 Reliant Technologies, Inc. Method and apparatus for monitoring and controlling laser-induced tissue treatment
US7372606B2 (en) 2003-12-31 2008-05-13 Reliant Technologies, Inc. Optical pattern generator using a single rotating component
US8545489B2 (en) * 2004-01-23 2013-10-01 Joseph Giovannoli Method and apparatus for skin reduction
US8535299B2 (en) * 2004-01-23 2013-09-17 Joseph Giovannoli Method and apparatus for skin reduction
AU2005231443B2 (en) 2004-04-01 2012-02-23 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
US20090088733A1 (en) * 2004-04-03 2009-04-02 Richard Rox Anderson Methods and apparatus for treatment of ocular melanosis
US9161815B2 (en) * 2004-06-21 2015-10-20 Kilolambda Technologies Ltd. Dermatological laser system and Method for Skin Resurfacing
US7837675B2 (en) 2004-07-22 2010-11-23 Shaser, Inc. Method and device for skin treatment with replaceable photosensitive window
US20060047281A1 (en) 2004-09-01 2006-03-02 Syneron Medical Ltd. Method and system for invasive skin treatment
US20060079947A1 (en) * 2004-09-28 2006-04-13 Tankovich Nikolai I Methods and apparatus for modulation of the immune response using light-based fractional treatment
US7635362B2 (en) * 2004-12-30 2009-12-22 Lutronic Corporation Method and apparatus treating area of the skin by using multipulse laser
US7722656B1 (en) 2005-02-25 2010-05-25 Kim Robin Segal Device and method for stimulating hair growth
WO2006109334A1 (en) * 2005-04-14 2006-10-19 Francesco Peluso Portable electric stimulator for wrinkles with interchangeable microelectrodes applicator
US7217265B2 (en) * 2005-05-18 2007-05-15 Cooltouch Incorporated Treatment of cellulite with mid-infrared radiation
US20060287662A1 (en) * 2005-05-26 2006-12-21 Ntk Enterprises, Inc. Device, system, and method for epithelium protection during cornea reshaping
EP1922009A2 (en) 2005-08-12 2008-05-21 Board of Regents, The University of Texas System Systems, devices, and methods for optically clearing tissue
AU2006292526A1 (en) 2005-09-15 2007-03-29 Palomar Medical Technologies, Inc. Skin optical characterization device
US7519253B2 (en) 2005-11-18 2009-04-14 Omni Sciences, Inc. Broadband or mid-infrared fiber light sources
WO2007095183A2 (en) * 2006-02-13 2007-08-23 Reliant Technologies, Inc. Laser system for treatment of skin laxity
US7691099B2 (en) * 2006-07-12 2010-04-06 Ntk Enterprises, Inc. Deuterated ocular solutions for LTK and other surgical eye procedures
HUE028578T2 (en) * 2006-07-13 2016-12-28 Reliant Tech Llc Apparatus for adjustable fractional optical dermatological treatment
EP2120761A1 (en) * 2007-03-02 2009-11-25 Candela Corporation Variable depth skin heating with lasers
US10183183B2 (en) * 2007-04-13 2019-01-22 Acoustic Medsystems, Inc. Acoustic applicators for controlled thermal modification of tissue
JP2010524591A (en) 2007-04-19 2010-07-22 ザ ファウンドリー, インコーポレイテッド Method and apparatus for reducing the production of sweat
JP5545668B2 (en) 2007-12-12 2014-07-09 ミラマー ラブズ, インコーポレイテッド System, apparatus method, and procedure for non-invasive tissue treatment using microwave energy
RU2523620C2 (en) 2007-04-19 2014-07-20 Мирамар Лэбс,Инк. Systems and methods for generating exposure on target tissue with using microwave energy
EP2762199B1 (en) 2007-12-12 2018-03-14 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
US9241763B2 (en) 2007-04-19 2016-01-26 Miramar Labs, Inc. Systems, apparatus, methods and procedures for the noninvasive treatment of tissue using microwave energy
KR100779954B1 (en) 2007-04-23 2007-11-28 다이노나(주) Laser skin perforator using laser
US8236036B1 (en) 2007-07-21 2012-08-07 Frost Ricky A Optical dermatological and medical treatment apparatus having replaceable laser diodes
JP5389025B2 (en) * 2007-08-01 2014-01-15 シネロン メディカル リミテッド Method and apparatus for collagen growth stimulation
EP2194899A4 (en) 2007-08-08 2012-11-28 Tria Beauty Inc Capacitive sensing method and device for detecting skin
US8603081B2 (en) * 2007-08-23 2013-12-10 Ntk Enterprises, Inc. System and method for defining and controlling LTK and other surgical eye procedures to produce little or no stromal collagen shrinkage
US7740651B2 (en) * 2007-09-28 2010-06-22 Candela Corporation Vacuum assisted treatment of the skin
US8632528B2 (en) 2008-04-11 2014-01-21 Jorge Fausto Ottini Methods for nonablative photorejuvenation
EP2268198A4 (en) 2008-04-25 2014-10-15 Tria Beauty Inc Optical sensor and method for identifying the presence of skin and the pigmentation of skin
EP2163218A1 (en) 2008-09-16 2010-03-17 Osyris Medical Device for treating part of a human or animal body comprising an instrument for dispensing and/or an instrument for locally sucking up treatment doses and means for controlling dosimetry
US20110190749A1 (en) 2008-11-24 2011-08-04 Mcmillan Kathleen Low Profile Apparatus and Method for Phototherapy
JP2012509720A (en) * 2008-11-24 2012-04-26 グラディアント リサーチ,エルエルシーGradiant Research,Llc Photothermal treatment of soft tissue
JP2012518459A (en) 2009-02-25 2012-08-16 トランスファーマ メディカル リミテッド Electrical skin regeneration
US20100249772A1 (en) * 2009-03-26 2010-09-30 Primaeva Medical, Inc. Treatment of skin deformation
US8328795B2 (en) * 2009-04-03 2012-12-11 Candela Corporation Skin resurfacing at 1930 nm
US20100331867A1 (en) * 2009-06-26 2010-12-30 Joseph Giovannoli Apparatus and method for dermal incision
US8357150B2 (en) 2009-07-20 2013-01-22 Syneron Medical Ltd. Method and apparatus for fractional skin treatment
US9919168B2 (en) 2009-07-23 2018-03-20 Palomar Medical Technologies, Inc. Method for improvement of cellulite appearance
JP2013500817A (en) 2009-08-04 2013-01-10 ポロゲン リミテッド Skin activation for beauty
CA2786262A1 (en) 2010-01-07 2011-07-14 Cheetah Omni, Llc Fiber lasers and mid-infrared light sources in methods and systems for selective biological tissue processing and spectroscopy
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
WO2012048241A2 (en) * 2010-10-07 2012-04-12 Gradiant Research, Llc Method and apparatus for skin cancer thermal therapy
US8968281B2 (en) 2011-07-28 2015-03-03 Illuminage Beauty, Ltd. Handholdable laser device featuring sensor for eye safe activation
US20130030506A1 (en) 2011-07-28 2013-01-31 Conopco, Inc., D/B/A Unilever Handholdable laser device featuring pulsing of a continuous wave laser
US20130030505A1 (en) 2011-07-28 2013-01-31 Conopco, Inc., D/B/A Unilever Handholdable laser device featuring flexible connection between a laser and a printed circuit board
US9314301B2 (en) 2011-08-01 2016-04-19 Miramar Labs, Inc. Applicator and tissue interface module for dermatological device
WO2014009826A2 (en) * 2012-07-09 2014-01-16 Koninklijke Philips N.V. Method and apparatus for treating a skin tissue.
EP2938259A4 (en) 2012-12-31 2016-08-17 Omni Medsci Inc Near-infrared lasers for non-invasive monitoring of glucose, ketones, hba1c, and other blood constituents
WO2014143276A2 (en) 2012-12-31 2014-09-18 Omni Medsci, Inc. Short-wave infrared super-continuum lasers for natural gas leak detection, exploration, and other active remote sensing applications
US9500635B2 (en) 2012-12-31 2016-11-22 Omni Medsci, Inc. Short-wave infrared super-continuum lasers for early detection of dental caries
EP3184038B1 (en) 2012-12-31 2019-02-20 Omni MedSci, Inc. Mouth guard with short-wave infrared super-continuum lasers for early detection of dental caries
US9993159B2 (en) 2012-12-31 2018-06-12 Omni Medsci, Inc. Near-infrared super-continuum lasers for early detection of breast and other cancers
US10045808B2 (en) 2013-12-03 2018-08-14 Kirn Medical Design, Llc Device for effecting change in tissue at a treatment site
US9113912B1 (en) 2015-01-21 2015-08-25 Serene Medical, Inc. Systems and devices to identify and limit nerve conduction
EP3247298A4 (en) * 2015-01-21 2018-12-26 Serene Medical, Inc. Systems and devices to identify and limit nerve conduction

Citations (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404350A (en) * 1964-06-02 1968-10-01 Arthur M. Muncheryan Directed-beam portable laser system
US3538919A (en) * 1967-04-07 1970-11-10 Gregory System Inc Depilation by means of laser energy
US3693623A (en) * 1970-12-25 1972-09-26 Gregory System Inc Photocoagulation means and method for depilation
US3834391A (en) * 1973-01-19 1974-09-10 Block Carol Ltd Method and apparatus for photoepilation
US3900034A (en) * 1974-04-10 1975-08-19 Us Energy Photochemical stimulation of nerves
US3916143A (en) * 1971-04-22 1975-10-28 Research Corp Branding living animals
US4388924A (en) * 1981-05-21 1983-06-21 Weissman Howard R Method for laser depilation
US4461294A (en) * 1982-01-20 1984-07-24 Baron Neville A Apparatus and process for recurving the cornea of an eye
US4608978A (en) * 1983-09-26 1986-09-02 Carol Block Limited Method and apparatus for photoepiltion
US4617926A (en) * 1982-07-09 1986-10-21 Sutton A Gunilla Depilation device and method
US4733660A (en) * 1984-08-07 1988-03-29 Medical Laser Research And Development Corporation Laser system for providing target specific energy deposition and damage
US4819669A (en) * 1985-03-29 1989-04-11 Politzer Eugene J Method and apparatus for shaving the beard
US4930504A (en) * 1987-11-13 1990-06-05 Diamantopoulos Costas A Device for biostimulation of tissue and method for treatment of tissue
US4976709A (en) * 1988-12-15 1990-12-11 Sand Bruce J Method for collagen treatment
US5000752A (en) * 1985-12-13 1991-03-19 William J. Hoskin Treatment apparatus and method
US5019034A (en) * 1988-01-21 1991-05-28 Massachusetts Institute Of Technology Control of transport of molecules across tissue using electroporation
US5059192A (en) * 1990-04-24 1991-10-22 Nardo Zaias Method of hair depilation
US5139494A (en) * 1988-11-10 1992-08-18 Premier Laser Systems, Inc. Multiwavelength medical laser method
US5139495A (en) * 1989-01-17 1992-08-18 S. L. T. Japan Co., Ltd. Bent and tapered laser light emitting probe
US5182857A (en) * 1989-11-02 1993-02-02 U.S. Philips Corp. Shaving apparatus
US5226907A (en) * 1991-10-29 1993-07-13 Tankovich Nikolai I Hair removal device and method
US5282797A (en) * 1989-05-30 1994-02-01 Cyrus Chess Method for treating cutaneous vascular lesions
US5290273A (en) * 1991-08-12 1994-03-01 Tan Oon T Laser treatment method for removing pigement containing lesions from the skin of a living human
US5304170A (en) * 1993-03-12 1994-04-19 Green Howard A Method of laser-induced tissue necrosis in carotenoid-containing skin structures
US5320618A (en) * 1990-04-09 1994-06-14 Morgan Gustafsson Device for treatment of undesired skin disfigurements
US5336217A (en) * 1986-04-24 1994-08-09 Institut National De La Sante Et De La Recherche Medicale (Insepm) Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5397327A (en) * 1993-07-27 1995-03-14 Coherent, Inc. Surgical laser handpiece for slit incisions
US5405368A (en) * 1992-10-20 1995-04-11 Esc Inc. Method and apparatus for therapeutic electromagnetic treatment
US5425728A (en) * 1991-10-29 1995-06-20 Tankovich; Nicolai I. Hair removal device and method
US5445634A (en) * 1991-09-25 1995-08-29 Keller; Gregory S. Method of laser cosmetic surgery
US5474549A (en) * 1991-07-09 1995-12-12 Laserscope Method and system for scanning a laser beam for controlled distribution of laser dosage
US5486172A (en) * 1989-05-30 1996-01-23 Chess; Cyrus Apparatus for treating cutaneous vascular lesions
US5522813A (en) * 1994-09-23 1996-06-04 Coherent, Inc. Method of treating veins
US5527350A (en) * 1993-02-24 1996-06-18 Star Medical Technologies, Inc. Pulsed infrared laser treatment of psoriasis
US5569242A (en) * 1994-05-06 1996-10-29 Lax; Ronald G. Method and apparatus for controlled contraction of soft tissue
US5606798A (en) * 1991-03-12 1997-03-04 Kelman; Elliot Hair cutting apparatus
US5643706A (en) * 1995-11-30 1997-07-01 Xerox Corporation Process for preparing electroconductive members
US5647866A (en) * 1993-11-09 1997-07-15 Zaias; Nardo Method of hair depilation
US5683380A (en) * 1995-03-29 1997-11-04 Esc Medical Systems Ltd. Method and apparatus for depilation using pulsed electromagnetic radiation
US5707403A (en) * 1993-02-24 1998-01-13 Star Medical Technologies, Inc. Method for the laser treatment of subsurface blood vessels
US5752948A (en) * 1991-10-29 1998-05-19 Thermolase Corporation Hair removal method
US5752949A (en) * 1991-10-29 1998-05-19 Thermolase Corporation Hair removal method
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US5810801A (en) * 1997-02-05 1998-09-22 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
US5860967A (en) * 1993-07-21 1999-01-19 Lucid, Inc. Dermatological laser treatment system with electronic visualization of the area being treated
US5868732A (en) * 1996-05-12 1999-02-09 Esc Medical Systems, Ltd. Cooling apparatus for cutaneous treatment employing a laser and method for operating same
US5897549A (en) * 1995-11-29 1999-04-27 Lumedics, Ltd. Transformation of unwanted tissue by deep laser heating of water
US5925035A (en) * 1991-10-29 1999-07-20 Thermolase Corporation Hair removal method
US5964749A (en) * 1995-09-15 1999-10-12 Esc Medical Systems Ltd. Method and apparatus for skin rejuvenation and wrinkle smoothing
US6083217A (en) * 1995-11-29 2000-07-04 Lumedics, Ltd. Destruction for unwanted tissue by deep laser heating of water
US6096029A (en) * 1997-02-24 2000-08-01 Laser Skin Toner, Inc. Laser method for subsurface cutaneous treatment
US6106514A (en) * 1996-08-12 2000-08-22 O'donnell, Jr.; Francis E. Laser method for subsurface cutaneous treatment
US6241753B1 (en) * 1995-05-05 2001-06-05 Thermage, Inc. Method for scar collagen formation and contraction
US6267771B1 (en) * 1991-10-29 2001-07-31 Thermotrex Corporation Hair removal device and method
US6280438B1 (en) * 1992-10-20 2001-08-28 Esc Medical Systems Ltd. Method and apparatus for electromagnetic treatment of the skin, including hair depilation

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3769963A (en) * 1972-03-31 1973-11-06 L Goldman Instrument for performing laser micro-surgery and diagnostic transillumination of living human tissue
US5002051A (en) * 1983-10-06 1991-03-26 Lasery Surgery Software, Inc. Method for closing tissue wounds using radiative energy beams
US5409479A (en) * 1983-10-06 1995-04-25 Premier Laser Systems, Inc. Method for closing tissue wounds using radiative energy beams
US4672969A (en) * 1983-10-06 1987-06-16 Sonomo Corporation Laser healing method
US4854320A (en) * 1983-10-06 1989-08-08 Laser Surgery Software, Inc. Laser healing method and apparatus
US5140984A (en) * 1983-10-06 1992-08-25 Proclosure, Inc. Laser healing method and apparatus
US5304169A (en) * 1985-09-27 1994-04-19 Laser Biotech, Inc. Method for collagen shrinkage
US5484432A (en) * 1985-09-27 1996-01-16 Laser Biotech, Inc. Collagen treatment apparatus
US5137530A (en) * 1985-09-27 1992-08-11 Sand Bruce J Collagen treatment apparatus
US5133708A (en) * 1988-01-14 1992-07-28 Smith Robert F Method for controlled corneal ablation
US5263951A (en) * 1989-04-21 1993-11-23 Kerus Medical Systems Correction of the optical focusing system of the eye using laser thermal keratoplasty
IL97553D0 (en) * 1990-03-14 1992-06-21 Candela Laser Corp Apparatus and method of treating pigmented lesions using pulsed irradiation
US5151098A (en) * 1990-07-23 1992-09-29 Hanspeter Loertscher Apparatus for controlled tissue ablation
US5360425A (en) * 1990-08-17 1994-11-01 Candela Laser Corporation Sclerostomy method and apparatus
AU647533B2 (en) * 1990-10-16 1994-03-24 Summit Technology, Inc. Laser thermokeratoplasty methods and apparatus
US5817089A (en) * 1991-10-29 1998-10-06 Thermolase Corporation Skin treatment process using laser
US5437658A (en) * 1992-10-07 1995-08-01 Summit Technology, Incorporated Method and system for laser thermokeratoplasty of the cornea
US5626631A (en) * 1992-10-20 1997-05-06 Esc Medical Systems Ltd. Method and apparatus for therapeutic electromagnetic treatment
CA2177580A1 (en) * 1993-12-02 1995-06-08 Michael J. Berry Laser system for reshaping the cornea
US5979454A (en) * 1995-05-15 1999-11-09 The Regents Of The University Of California Method and apparatus for causing rapid and deep spatially selective coagulation during thermally mediated therapeutic procedures
JP3263275B2 (en) * 1994-04-05 2002-03-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Apparatus and flame-shaped spots nevi laser processing apparatus for laser treatment of biological tissue
US5464436A (en) * 1994-04-28 1995-11-07 Lasermedics, Inc. Method of performing laser therapy
US5611795A (en) * 1995-02-03 1997-03-18 Laser Industries, Ltd. Laser facial rejuvenation
US5445146A (en) * 1995-03-31 1995-08-29 Bellinger; Gary J. Biological tissue stimulation by low level optical energy
US5868731A (en) * 1996-03-04 1999-02-09 Innotech Usa, Inc. Laser surgical device and method of its use
AU2318197A (en) * 1996-04-10 1997-10-29 New Star Lasers, Inc. Improved method and device for laser induced shrinking of collagen
US5820626A (en) * 1996-07-30 1998-10-13 Laser Aesthetics, Inc. Cooling laser handpiece with refillable coolant reservoir
US6162211A (en) * 1996-12-05 2000-12-19 Thermolase Corporation Skin enhancement using laser light
AU1805399A (en) * 1997-12-04 1999-06-16 Thermolase Corporation Skin cooling apparatus and method for laser assisted skin treatments
US5997530A (en) * 1998-04-13 1999-12-07 The Regents Of The University Of California Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations
US6077294A (en) 1998-06-11 2000-06-20 Cynosure, Inc. Method for non-invasive wrinkle removal and skin treatment

Patent Citations (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3404350A (en) * 1964-06-02 1968-10-01 Arthur M. Muncheryan Directed-beam portable laser system
US3538919A (en) * 1967-04-07 1970-11-10 Gregory System Inc Depilation by means of laser energy
US3693623A (en) * 1970-12-25 1972-09-26 Gregory System Inc Photocoagulation means and method for depilation
US3916143A (en) * 1971-04-22 1975-10-28 Research Corp Branding living animals
US3834391A (en) * 1973-01-19 1974-09-10 Block Carol Ltd Method and apparatus for photoepilation
US3900034A (en) * 1974-04-10 1975-08-19 Us Energy Photochemical stimulation of nerves
US4388924A (en) * 1981-05-21 1983-06-21 Weissman Howard R Method for laser depilation
US4461294A (en) * 1982-01-20 1984-07-24 Baron Neville A Apparatus and process for recurving the cornea of an eye
US4617926A (en) * 1982-07-09 1986-10-21 Sutton A Gunilla Depilation device and method
US4608978A (en) * 1983-09-26 1986-09-02 Carol Block Limited Method and apparatus for photoepiltion
US4733660A (en) * 1984-08-07 1988-03-29 Medical Laser Research And Development Corporation Laser system for providing target specific energy deposition and damage
US4819669A (en) * 1985-03-29 1989-04-11 Politzer Eugene J Method and apparatus for shaving the beard
US5000752A (en) * 1985-12-13 1991-03-19 William J. Hoskin Treatment apparatus and method
US5336217A (en) * 1986-04-24 1994-08-09 Institut National De La Sante Et De La Recherche Medicale (Insepm) Process for treatment by irradiating an area of a body, and treatment apparatus usable in dermatology for the treatment of cutaneous angio dysplasias
US4930504A (en) * 1987-11-13 1990-06-05 Diamantopoulos Costas A Device for biostimulation of tissue and method for treatment of tissue
US5019034A (en) * 1988-01-21 1991-05-28 Massachusetts Institute Of Technology Control of transport of molecules across tissue using electroporation
US5019034B1 (en) * 1988-01-21 1995-08-15 Massachusetts Inst Technology Control of transport of molecules across tissue using electroporation
US5139494A (en) * 1988-11-10 1992-08-18 Premier Laser Systems, Inc. Multiwavelength medical laser method
US4976709A (en) * 1988-12-15 1990-12-11 Sand Bruce J Method for collagen treatment
US5139495A (en) * 1989-01-17 1992-08-18 S. L. T. Japan Co., Ltd. Bent and tapered laser light emitting probe
US5486172A (en) * 1989-05-30 1996-01-23 Chess; Cyrus Apparatus for treating cutaneous vascular lesions
US5282797A (en) * 1989-05-30 1994-02-01 Cyrus Chess Method for treating cutaneous vascular lesions
US5182857A (en) * 1989-11-02 1993-02-02 U.S. Philips Corp. Shaving apparatus
US5320618A (en) * 1990-04-09 1994-06-14 Morgan Gustafsson Device for treatment of undesired skin disfigurements
US5059192A (en) * 1990-04-24 1991-10-22 Nardo Zaias Method of hair depilation
US5606798A (en) * 1991-03-12 1997-03-04 Kelman; Elliot Hair cutting apparatus
US5474549A (en) * 1991-07-09 1995-12-12 Laserscope Method and system for scanning a laser beam for controlled distribution of laser dosage
US5290273A (en) * 1991-08-12 1994-03-01 Tan Oon T Laser treatment method for removing pigement containing lesions from the skin of a living human
US5445634A (en) * 1991-09-25 1995-08-29 Keller; Gregory S. Method of laser cosmetic surgery
US6267771B1 (en) * 1991-10-29 2001-07-31 Thermotrex Corporation Hair removal device and method
US5925035A (en) * 1991-10-29 1999-07-20 Thermolase Corporation Hair removal method
US5425728A (en) * 1991-10-29 1995-06-20 Tankovich; Nicolai I. Hair removal device and method
US5752948A (en) * 1991-10-29 1998-05-19 Thermolase Corporation Hair removal method
US5226907A (en) * 1991-10-29 1993-07-13 Tankovich Nikolai I Hair removal device and method
US5752949A (en) * 1991-10-29 1998-05-19 Thermolase Corporation Hair removal method
US5344418A (en) * 1991-12-12 1994-09-06 Shahriar Ghaffari Optical system for treatment of vascular lesions
US5405368A (en) * 1992-10-20 1995-04-11 Esc Inc. Method and apparatus for therapeutic electromagnetic treatment
US6280438B1 (en) * 1992-10-20 2001-08-28 Esc Medical Systems Ltd. Method and apparatus for electromagnetic treatment of the skin, including hair depilation
US5527350A (en) * 1993-02-24 1996-06-18 Star Medical Technologies, Inc. Pulsed infrared laser treatment of psoriasis
US5707403A (en) * 1993-02-24 1998-01-13 Star Medical Technologies, Inc. Method for the laser treatment of subsurface blood vessels
US5304170A (en) * 1993-03-12 1994-04-19 Green Howard A Method of laser-induced tissue necrosis in carotenoid-containing skin structures
US5860967A (en) * 1993-07-21 1999-01-19 Lucid, Inc. Dermatological laser treatment system with electronic visualization of the area being treated
US5397327A (en) * 1993-07-27 1995-03-14 Coherent, Inc. Surgical laser handpiece for slit incisions
US5647866A (en) * 1993-11-09 1997-07-15 Zaias; Nardo Method of hair depilation
US5569242A (en) * 1994-05-06 1996-10-29 Lax; Ronald G. Method and apparatus for controlled contraction of soft tissue
US5522813A (en) * 1994-09-23 1996-06-04 Coherent, Inc. Method of treating veins
US5683380A (en) * 1995-03-29 1997-11-04 Esc Medical Systems Ltd. Method and apparatus for depilation using pulsed electromagnetic radiation
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US6241753B1 (en) * 1995-05-05 2001-06-05 Thermage, Inc. Method for scar collagen formation and contraction
US5919219A (en) * 1995-05-05 1999-07-06 Thermage, Inc. Method for controlled contraction of collagen tissue using RF energy
US5964749A (en) * 1995-09-15 1999-10-12 Esc Medical Systems Ltd. Method and apparatus for skin rejuvenation and wrinkle smoothing
US6083217A (en) * 1995-11-29 2000-07-04 Lumedics, Ltd. Destruction for unwanted tissue by deep laser heating of water
US5897549A (en) * 1995-11-29 1999-04-27 Lumedics, Ltd. Transformation of unwanted tissue by deep laser heating of water
US5643706A (en) * 1995-11-30 1997-07-01 Xerox Corporation Process for preparing electroconductive members
US5868732A (en) * 1996-05-12 1999-02-09 Esc Medical Systems, Ltd. Cooling apparatus for cutaneous treatment employing a laser and method for operating same
US6106514A (en) * 1996-08-12 2000-08-22 O'donnell, Jr.; Francis E. Laser method for subsurface cutaneous treatment
US6659999B1 (en) * 1997-02-05 2003-12-09 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
US6120497A (en) * 1997-02-05 2000-09-19 Massachusetts General Hospital Method and apparatus for treating wrinkles in skin using radiation
US5810801A (en) * 1997-02-05 1998-09-22 Candela Corporation Method and apparatus for treating wrinkles in skin using radiation
US6096029A (en) * 1997-02-24 2000-08-01 Laser Skin Toner, Inc. Laser method for subsurface cutaneous treatment

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060197247A1 (en) * 1998-02-12 2006-09-07 Moldflow Pty Ltd Automated Molding Technology For Thermoplastic Injection Molding
US20030109860A1 (en) * 2001-12-12 2003-06-12 Michael Black Multiple laser treatment
US8915948B2 (en) 2002-06-19 2014-12-23 Palomar Medical Technologies, Llc Method and apparatus for photothermal treatment of tissue at depth
US20040082940A1 (en) * 2002-10-22 2004-04-29 Michael Black Dermatological apparatus and method
US9351792B2 (en) 2003-03-27 2016-05-31 The General Hospital Corporation Method and apparatus for dermatological treatment and fractional skin resurfacing
US8870856B2 (en) * 2003-08-25 2014-10-28 Cutera, Inc. Method for heating skin using light to provide tissue treatment
US20050171581A1 (en) * 2003-08-25 2005-08-04 Connors Kevin P. System and method for heating skin using light to provide tissue treatment
US7722600B2 (en) 2003-08-25 2010-05-25 Cutera, Inc. System and method for heating skin using light to provide tissue treatment
US20050049658A1 (en) * 2003-08-25 2005-03-03 Connors Kevin P. System and method for heating skin using light to provide tissue treatment
US8915906B2 (en) 2003-08-25 2014-12-23 Cutera, Inc. Method for treatment of post-partum abdominal skin redundancy or laxity
US20050259306A1 (en) * 2003-12-31 2005-11-24 Broome Barry G Two-dimensional optical scan system using a counter-rotating disk scanner
US20060276778A1 (en) * 2003-12-31 2006-12-07 Reliant Technologies, Inc. Multi-Spot Laser Surgical Apparatus and Method
US20080043306A1 (en) * 2003-12-31 2008-02-21 Debenedictis Leonard C High Speed, High Efficiency Optical Pattern Generator Using Rotating Optical Elements
US20050143719A1 (en) * 2003-12-31 2005-06-30 Sink Robert K. Multi-spot laser surgical apparatus and method
US20050141068A1 (en) * 2003-12-31 2005-06-30 Debenedictis Leonard C. High speed, high efficiency optical pattern generator using rotating optical elements
US20080068694A1 (en) * 2003-12-31 2008-03-20 Reliant Technologies, Inc. High speed, high efficiency optical pattern generator using rotating optical elements
US8291913B2 (en) 2004-06-14 2012-10-23 Reliant Technologies, Inc. Adaptive control of optical pulses for laser medicine
US20050278002A1 (en) * 2004-06-14 2005-12-15 David Eimerl Adaptive control of optical pulses for laser medicine
US8277495B2 (en) 2005-01-13 2012-10-02 Candela Corporation Method and apparatus for treating a diseased nail
US7856985B2 (en) 2005-04-22 2010-12-28 Cynosure, Inc. Method of treatment body tissue using a non-uniform laser beam
US20110152847A1 (en) * 2005-04-22 2011-06-23 Cynosure, Inc. Methods and systems for laser treatment using non-uniform output beam
US20060247609A1 (en) * 2005-04-22 2006-11-02 Mirkov Mirko Georgiev Methods and systems for laser treatment using non-uniform output beam
US20100217248A1 (en) * 2005-04-22 2010-08-26 Mirkov Mirko Georgiev Methods And Systems For Laser Treatment Using Non-Uniform Output Beam
US8317779B2 (en) 2005-04-22 2012-11-27 Cynosure, Inc. Methods and systems for laser treatment using non-uniform output beam
US8322348B2 (en) 2005-04-22 2012-12-04 Cynosure, Inc. Methods and systems for laser treatment using non-uniform output beam
WO2006116141A1 (en) * 2005-04-22 2006-11-02 Cynosure, Inc. Methods and systems for laser treatment using non-uniform output beam
US9028469B2 (en) 2005-09-28 2015-05-12 Candela Corporation Method of treating cellulite
US7891362B2 (en) 2005-12-23 2011-02-22 Candela Corporation Methods for treating pigmentary and vascular abnormalities in a dermal region
US8246611B2 (en) 2006-06-14 2012-08-21 Candela Corporation Treatment of skin by spatial modulation of thermal heating
US9486285B2 (en) 2006-06-14 2016-11-08 Candela Corporation Treatment of skin by spatial modulation of thermal heating
US9028536B2 (en) 2006-08-02 2015-05-12 Cynosure, Inc. Picosecond laser apparatus and methods for its operation and use
US20080161745A1 (en) * 2006-09-08 2008-07-03 Oliver Stumpp Bleaching of contrast enhancing agent applied to skin for use with a dermatological treatment system
US9780518B2 (en) 2012-04-18 2017-10-03 Cynosure, Inc. Picosecond laser apparatus and methods for treating target tissues with same
US10305244B2 (en) 2012-04-18 2019-05-28 Cynosure, Llc Picosecond laser apparatus and methods for treating target tissues with same
US10245107B2 (en) 2013-03-15 2019-04-02 Cynosure, Inc. Picosecond optical radiation systems and methods of use
US10285757B2 (en) 2013-03-15 2019-05-14 Cynosure, Llc Picosecond optical radiation systems and methods of use

Also Published As

Publication number Publication date
US6120497A (en) 2000-09-19
US20080269733A1 (en) 2008-10-30
EP1011811B1 (en) 2005-06-29
EP1011811A1 (en) 2000-06-28
DE69830732D1 (en) 2005-08-04
DE69830732T2 (en) 2006-05-04
US20050256515A1 (en) 2005-11-17
US5810801A (en) 1998-09-22
US6659999B1 (en) 2003-12-09
WO1998033558A1 (en) 1998-08-06

Similar Documents

Publication Publication Date Title
Hruza et al. Laser skin resurfacing
AU771801B2 (en) Skin wrinkle reduction using pulsed light
EP1180982B1 (en) Apparatus for dynamic cooling of biological tissues during laser surgery
ES2227387T5 (en) Hair removal with the help of optical impulses
CA2185196C (en) Method and apparatus for skin rejuvenation and wrinkle smoothing
Kono et al. Prospective direct comparison study of fractional resurfacing using different fluences and densities for skin rejuvenation in Asians
Walgrave et al. Evaluation of a novel fractional resurfacing device for treatment of acne scarring
US6059820A (en) Tissue cooling rod for laser surgery
CN1836639B (en) Method and apparatus for therapeutic emr treatment of the skin
US6106514A (en) Laser method for subsurface cutaneous treatment
US8277495B2 (en) Method and apparatus for treating a diseased nail
US5527350A (en) Pulsed infrared laser treatment of psoriasis
US5984915A (en) Percutaneous laser treatment
AU704892B2 (en) Hair removal by selective photothermolysis with an alexandrite laser
US6050990A (en) Methods and devices for inhibiting hair growth and related skin treatments
US6451007B1 (en) Thermal quenching of tissue
EP0519964B1 (en) Apparatus of treating pigmented lesions using pulsed irradiation
US8979830B2 (en) Treatment of cellulite and adipose tissue with mid-infrared radiation
US6235015B1 (en) Method and apparatus for selective hair depilation using a scanned beam of light at 600 to 1000 nm
CA2339252C (en) Treatment of pigmented tissues using optical energy
US6030378A (en) Method of hair removal by transcutaneous application of laser light
US6443946B2 (en) Apparatus for wrinkle removal
Geronemus Q-switched ruby laser therapy of nevus of Ota
US20020169442A1 (en) Device and a method for treating skin conditions
JP4495894B2 (en) Apparatus for performing a medical treatment by using a long period of time of electromagnetic radiation

Legal Events

Date Code Title Description
AS Assignment

Owner name: GENERAL HOSPITAL CORPORTATION, MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ANDERSON, R. ROX;REEL/FRAME:017746/0929

Effective date: 19981015

Owner name: NAVY, UNITED STATES OF AMERICA, THE, AS REPRESENTE

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ROSS, JR., EDWARD V.;REEL/FRAME:017746/0932

Effective date: 19970207

Owner name: CANDELA CORPORATION, MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:HSIA, JAMES C.;MCMILLAN, KATHLEEN;REEL/FRAME:017746/0923;SIGNING DATES FROM 19961231 TO 19970114

AS Assignment

Owner name: CANDELA CORPORATION, MASSACHUSETTS

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY;REEL/FRAME:018645/0948

Effective date: 20061215

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION