US20040005244A1 - Drive system for an apparatus for staining specimens - Google Patents

Drive system for an apparatus for staining specimens Download PDF

Info

Publication number
US20040005244A1
US20040005244A1 US10/611,768 US61176803A US2004005244A1 US 20040005244 A1 US20040005244 A1 US 20040005244A1 US 61176803 A US61176803 A US 61176803A US 2004005244 A1 US2004005244 A1 US 2004005244A1
Authority
US
United States
Prior art keywords
drive system
defined
side wall
crank
motor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
US10/611,768
Other versions
US7198752B2 (en
Inventor
Stefan Thiem
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leica Biosystems Nusslock GmbH
Original Assignee
Leica Biosystems Nusslock GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE20210451.6 priority Critical
Priority to DE20210451U priority patent/DE20210451U1/en
Application filed by Leica Biosystems Nusslock GmbH filed Critical Leica Biosystems Nusslock GmbH
Assigned to LEICA MICROSYSTEMS NUSSLOCH GMBH reassignment LEICA MICROSYSTEMS NUSSLOCH GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: THIEM, STEFAN
Publication of US20040005244A1 publication Critical patent/US20040005244A1/en
Publication of US7198752B2 publication Critical patent/US7198752B2/en
Application granted granted Critical
Assigned to LEICA BIOSYSTEMS NUSSLOCH GMBH reassignment LEICA BIOSYSTEMS NUSSLOCH GMBH CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: LEICA MICROSYSTEMS NUSSLOCH GMBH
Application status is Expired - Fee Related legal-status Critical
Adjusted expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30Staining; Impregnating Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31Apparatus therefor

Abstract

For automatic transportation and lifting and lowering of specimens in an automatic stainer, a drive system comprises a motor (16) and a side wall (40), the motor (16) being coupled on the drive side to a first (12) and a second (14) crank system. The first (12) and second (14) crank systems are respectively coupled to the side wall (40).

Description

    CROSS REFERENCE TO RELATED APPLICATIONS
  • This application claims priority of the German utility model application 202 10 451.6 filed Jul. 5, 2002 which is incorporated by reference herein. [0001]
  • FIELD OF THE INVENTION
  • The invention concerns a drive system for an automatic stainer for staining specimens. [0002]
  • BACKGROUND OF THE INVENTION
  • In the microscopic examination of specimens, it is often necessary to mark certain parts or properties of the specimen by staining. In this way, for example, the structure in cells and tissues can be differentiated and made visible in high-contrast fashion. In order to emphasize structures selectively, it is necessary to adhere to certain staining procedures, called the “staining program,” which depend on the particular preparations to be treated and the specific properties to be examined within the preparations. In practical use, a standard staining process has proven successful (in addition to various special stains) for this purpose. In this so-called H.E. staining process, the specimens pass through a number of processing stages using xylene, alcohol, eosin, hematoxylin, acetic acid, and water. [0003]
  • Since the staining process is often very time-consuming, it is advantageous to stain a large number of preparations in a single staining program or to automate the entire staining operation. In the staining of histological preparations for microscopic examinations, for example, the physical and chemical properties of the structures in the cells and tissues are utilized for the binding of certain dyes. Both natural substances and synthetic dyes are used for histological stains. [0004]
  • A number of types of automatic stainers, which automatically convey the specimens to the respective processing steps, are used for staining specimens. The automatic stainers differ in terms of their mechanical configuration and manner of operation. [0005]
  • DE 41 17 831 and DE 41 17 833 disclose several automatic staining methods and apparatuses. In an automatic stainer of the Mediate company, a specimen slide holder containing the specimen slides with histological preparations is transported into treatment stations located one behind another. The preparations are then lowered into a treatment station (called a “trough”) and have applied to them an additional up-and-down motion that promotes complete staining. The motion mechanism of this device comprises two panels equipped with notches for receiving the specimens. One of these panels is located in front of the troughs and the other is located behind them. The two panels are each mounted on the frame of the device using a cross-type guide. A motor moves the panels, via a crank, in the vertical direction in order to extract the specimens from the reagent containers and lower them into the reagent containers. A second motor moves the specimens by way of a crank, when they have been extracted from the reagent containers, horizontally over the next reagent container. There they are lowered by a motion of the first motor. A third motor moves the panels, via a cam panel, vertically up and down in order to continuously mix the reagents. In this embodiment, two cross-type guides and three motors are required in order to perform the motions necessary for the staining process. The corresponding parts for motion transfer, and a number of sensors for each motor for position sensing, are additionally needed. [0006]
  • Also disclosed by the Shandon company is a staining device operating on the so-called carousel method. Here the treatment stations are arranged in a circle one behind another. The sequence in which the treatment stations can be traveled to is accordingly predefined. [0007]
  • U.S. Pat. No. 3,691,988 discloses a staining device for staining preparations that has a straight-line guide above the staining baths. A guide block that carries a number of preparations is arranged displaceably on this guide. That number of preparations is positioned by means of a chain drive, together with the guide block, over the desired staining bath and then lowered into the staining bath. [0008]
  • U.S. Pat. No. 4,911,098 additionally discloses an automatic staining apparatus that, using a gripper, can automatically lower into a staining bath a number of preparations that are to be stained. A tilting mechanism is provided for the gripper so that the chemical substances can easily drain off from the specimens being stained. [0009]
  • SUMMARY OF THE INVENTION
  • It is the object of the invention to propose an improved drive system for an automatic staining device, with which good staining results can be obtained even at high throughput rates. [0010]
  • According to the present invention, this object is achieved by way of a drive system for an automatic stainer comprising a motor ([0011] 16); a side wall (40) for carrying specimens to be stained; and a first crank system (12) and a second crank system (14) each coupled to the side wall (40) and connected to the motor (16); wherein the motor (16) drives both the first and second crank systems (12, 14).
  • The drive system for an automatic stainer is thus characterized in that a motor is provided which is connected on the drive side to a first and a second crank system. The crank systems are in turn coupled to a side wall of the automatic stainer that is designed to carry specimens. By way of this drive configuration, the first and the second crank system can be set in motion upon operation of the motor. Since the two crank systems are coupled to the side wall, the motion of each of the crank systems is transferred to the side wall. It is thus possible, using a single motor, to transfer to the side wall of the automatic stainer a motion generated by the motor, different motion curves thereby being transferred via the two crank systems to the side wall of the automatic stainer. [0012]
  • In a preferred embodiment, the two crank systems are mounted on a base frame of the automatic stainer. The crank systems each have a rotatably mounted shaft. Arranged at each of the end faces of the shafts are levers that extend parallel to one another. Each of the levers can have, at one of its ends, a rotatably mounted roller. The motor is advantageously arranged between the two crank systems, and on the drive side is in working engagement with the crank systems. The working engagement is preferably created by way of a toothed belt that runs from the motor respectively to the first and to the second crank system. With these two toothed belts, it is correspondingly possible to impose synchronous operation of the two crank systems. [0013]
  • To allow transport of the specimen preparations that are to be stained, there is provided on the automatic stainer a side wall which has notches that are recessed, for example, into panels of the side wall. The two panels are arranged parallel to one another and are joined rigidly to one another via transverse connections. At the two ends, each panel possesses a guide track. One of the crank systems can engage in each of these guide tracks, so that the motion of the crank system can be transferred to the frame. The guide track is preferably recessed into the frame by the fact that elements into which the guide track is recessed, in particular is milled, are attached onto the side wall. Advantageously, these guide tracks have two surfaces that slope outward. [0014]
  • In a preferred embodiment of the invention, the rollers that are mounted rotatably on the cranks run in the guide tracks. Thus as soon as the motor begins to rotate, the rollers arranged and rotatably mounted at the ends of the cranks describe complete circles. Without additional actions, this complete-circle motion would of itself be transferred correspondingly to the side wall. In order to lower the specimens that are present in the reagents vertically into the reagent containers and also pull them vertically back out, this complete-circle motion is trimmed. For that purpose, a gate is mounted rigidly on a base frame, and into it engages a peg that is attached to the side wall. [0015]
  • With the use of the drive system according to the present invention, transport of the specimens in the automatic stainer can be accomplished using a single motor. The side wall does not require a separate guide, since the drive mechanism that converts the rotary motion of the motor simultaneously provides guidance of the panels.[0016]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • Further advantages and advantageous embodiments of the invention are the subject matter of the Figures below and the descriptions thereof, in which true-to-scale reproduction has been dispensed with in the interest of clarity. Specifically: [0017]
  • FIG. 1 is a perspective view of the drive system according to the present invention; and [0018]
  • FIG. 2 shows a side wall of the automatic stainer that can be coupled to the crank system.[0019]
  • DETAILED DESCRIPTION OF THE INVENTION
  • FIG. 1 shows the drive portion of an automatic stainer [0020] 10 in a perspective depiction. The drive system for automatic stainer 10 is implemented by way of a motor 16, a first crank system 12, and a second crank system 14. The two crank systems 12, 14 are connected to motor 16 on the drive side and are driven by toothed belts 18. The two crank systems 12, 14 are of substantially identical construction.
  • Four bearing blocks [0021] 28 are attached for this purpose on a base frame 26. Ball bearings 29 are pressed into bearing blocks 28. Two shafts 20 are mounted rotatably by means of ball bearings 29. Levers 19 are mounted rigidly on, in particular pressed onto, each of the ends of shafts 20. At the free ends of levers 19, a ball bearing 13, onto which a roller 17 is set, is provided on a pin 11.
  • Between bearing blocks [0022] 28, toothed-belt pulleys 15 are arranged on shafts 20. They are joined rigidly to the respective shaft 20. From toothed-belt pulleys 15, toothed belts 18 run toward motor 16. A double toothed pulley 32 that drives toothed belts 18 is mounted on motor shaft 30. Displaceable tension pulleys 34 can be provided for tensioning toothed belts 18. Mounted rigidly on shaft 20 of second crank system 14 is a coding disk 36 with which an angle code can be identified and thus the exact angular position of shaft 20 can be ascertained. For that purpose, coding disk 36 can have, for example, an imprinted code that can be read by sensors. These sensors can, for example, be arranged on a board 38 or associated with board 38. It is correspondingly possible, using this coding disk, to identify the respective present position of the entire transport mechanism, and thus to control the motion of the transport mechanism. Board 38 can, for example, be attached to base frame 26 using an angle bracket 39.
  • FIG. 2 shows a side wall [0023] 40 that can be coupled to the two crank systems 12, 14. Side wall 40 has two panels 44 that form a lateral boundary of the side wall. The two panels 44 are fixed in position with respect to one another at their long-side ends by transverse connectors 43 in such a way that they are aligned parallel. On each of panels 44, guide tracks 24 are provided at the two lower ends. Advantageously, these guide tracks are machined into so-called assembly elements 41 that are connected immovably to panels 44 and thus to side wall 40. The assembly elements can be produced from any suitable material, in particular from sheet metal or a strong plastic. Guide track 24 extends in an outward-sloping fashion. As also depicted in FIG. 1, a gate 22 is additionally attached to base frame 26. Gate 22 possesses a milled-in gate guide track 24 in which a peg 46, attached to side wall 40, can engage.
  • As soon as motor [0024] 16 is put into operation, the drive-side connection of motor 16 to first and second crank system 14, 14 causes levers 19 to be moved out of their lower position. Because of the connection of side wall 40 to the drive system, side wall 40 follows that motion until peg 46 comes to a stop against the outer boundary of gate guide track 48 of gate 22. At this point, panels 44 and therefore frame 40 are lifted vertically upward. Levers 19 continue to describe their circular path, and rollers 17 follow outward under guide track 24 of guide 41. Since guide track 24 is tilted outward, a horizontal force component is created which pushes pin 46 against the outer side of gate guide track 48. This prevents any horizontal motion of panels 44 during the lifting operation. As soon as roller 17 located on lever 19 approaches the upper reversing point of its circular motion, upper point 47 of guide track 24 snaps back onto roller 17. Side wall 40 then once again follows the circular path of rollers 17 until pin 46 touches gate guide track 48 on the other side of gate 22. From that point on, side wall 40 moves vertically downward.
  • Parts List [0025]
  • [0026] 10 Automatic stainer
  • [0027] 11 Pin
  • [0028] 12 First crank system
  • [0029] 13 Ball bearing
  • [0030] 14 Second crank system
  • [0031] 15 Toothed-belt pulley
  • [0032] 16 Motor
  • [0033] 17 Roller
  • [0034] 18 Toothed belt
  • [0035] 19 Lever
  • [0036] 20 Shaft
  • [0037] 22 Gate
  • [0038] 24 Guide track
  • [0039] 26 Base frame
  • [0040] 28 Bearing block
  • [0041] 30 Motor shaft
  • [0042] 32 Double toothed pulley
  • [0043] 34 Tension pulleys
  • [0044] 36 Coding disk
  • [0045] 38 Board
  • [0046] 39 Angle bracket
  • [0047] 40 Side wall
  • [0048] 41 Assembly element
  • [0049] 42 Guide
  • [0050] 43 Transverse connector
  • [0051] 44 Panel
  • [0052] 46 Peg
  • [0053] 47 Upper point
  • [0054] 48 Gate guide track

Claims (11)

What is claimed is:
1. A drive system for an automatic stainer (10), the drive system comprising:
a motor (16);
a side wall (40) for carrying specimens to be stained;
a first crank system (12) and a second crank system (14) each coupled to the side wall (40) and connected to the motor (16);
wherein the motor (16) drives both the first and second crank systems (12, 14).
2. The drive system as defined in claim 1, wherein the first and second crank systems (12, 14) are each connected to the motor (16) by respective power transfer means for providing synchronized operation of the first and second crank systems (12, 14).
3. The drive system as defined in claim 2, wherein the power transfer means includes a toothed belt.
4. The drive system as defined in claim 2, wherein each of the first and second crank systems (12, 14) includes a rotatably mounted shaft (20) and a pair of levers (19) arranged one at each end of the shaft (20).
5. The drive system as defined in claim 4, further comprising a plurality of rollers (17) rotatably mounted one on each of the levers (19).
6. The drive system as defined in claim 5, wherein the side wall (40) includes a plurality of sloped guide tracks (24) into which the plurality of rollers (17) engage, respectively.
7. The drive system as defined in claim 6, wherein the plurality of guide tracks (24) are respectively formed as recesses in an associated assembly element (41) mounted on the side wall (40).
8. The drive system as defined in claim 7, wherein the side wall (40) includes two panels (44) arranged opposite one another and a transverse connector (46) for joining the two panels (44) to one another.
9. The drive system as defined in claim 1, further comprising a gate (22) fixed on the automatic stainer (10) and coupled to at least one of the first and second crank systems (12, 14).
10. The drive system as defined in claim 9, wherein the gate (22) comprises a gate guide track (48), and the side wall (40) includes a peg (46) arranged to engage the guide track (48).
11. The drive system as defined in claim 4, further comprising an angle sensor arranged to sense rotation of the shaft (20) of one of the first and second crank systems (12, 14).
US10/611,768 2002-07-05 2003-07-01 Drive system for an apparatus for staining specimens Expired - Fee Related US7198752B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE20210451.6 2002-07-05
DE20210451U DE20210451U1 (en) 2002-07-05 2002-07-05 Drive for an apparatus for coloring of objects

Publications (2)

Publication Number Publication Date
US20040005244A1 true US20040005244A1 (en) 2004-01-08
US7198752B2 US7198752B2 (en) 2007-04-03

Family

ID=7972903

Family Applications (1)

Application Number Title Priority Date Filing Date
US10/611,768 Expired - Fee Related US7198752B2 (en) 2002-07-05 2003-07-01 Drive system for an apparatus for staining specimens

Country Status (2)

Country Link
US (1) US7198752B2 (en)
DE (1) DE20210451U1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050064535A1 (en) * 2002-12-20 2005-03-24 Dako Cytomation Denmark A/S Method and apparatus for pretreatment of tissue slides
US20080089808A1 (en) * 2006-10-17 2008-04-17 Preyas Sarabhai Shah Slide stainer with multiple heater stations
WO2018072735A1 (en) * 2016-10-21 2018-04-26 陕西高源体外诊断试剂有限公司 Color-assisted interpretation device for frd epithelial tissue staining applicator

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2851101C (en) 2010-10-06 2017-02-14 Biocare Medical, Llc Methods and systems for efficient processing of biological samples
US9945763B1 (en) 2011-02-18 2018-04-17 Biocare Medical, Llc Methods and systems for immunohistochemistry heat retrieval of biological samples

Citations (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1919169A (en) * 1931-06-05 1933-07-18 Western Union Telegraph Co Drag conveyer discharge
US3428027A (en) * 1967-07-24 1969-02-18 Badger Northland Inc Livestock feeding apparatus
US3691988A (en) * 1971-04-05 1972-09-19 Thermolyne Corp Apparatus for automatically staining microscope slides
US4152390A (en) * 1976-12-17 1979-05-01 Eastman Kodak Company Chemical analyzer
US4401020A (en) * 1981-12-16 1983-08-30 Seaco Industries Vegetable banding apparatus
US4756399A (en) * 1984-02-24 1988-07-12 Meccanizzazione Postale E Automazione S.P.A. Belt conveyor for the sorting of sundry articles
US4797258A (en) * 1984-11-10 1989-01-10 Mochida Pharmaceutical Co., Ltd. Chemical reaction apparatus
US4809842A (en) * 1985-09-04 1989-03-07 Nabisco Brands, Inc. Selective ejection conveyor
US4861553A (en) * 1987-06-11 1989-08-29 Technicon Instruments Corporation Automatic sampling system
US4911098A (en) * 1987-12-28 1990-03-27 Shiraimatsu & Co., Ltd. Automatic straining apparatus for slide specimens
US5209903A (en) * 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5909796A (en) * 1995-11-16 1999-06-08 Sandvik Ab Method and apparatus for loading articles onto vertically spaced platforms of a moving transport device
US6074617A (en) * 1998-07-10 2000-06-13 Bayer Corporation Stat shuttle adapter and transport device
US6227376B1 (en) * 1999-05-07 2001-05-08 Hormel Foods, Llc Two-directional reject and make-up conveyor system
US6355487B2 (en) * 1999-04-16 2002-03-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US6387326B1 (en) * 1994-07-19 2002-05-14 Fisher Scientific Company L.L.C. Automated slide staining system and method thereof
US20020104736A1 (en) * 2001-02-02 2002-08-08 Peppel George W. Vertical diverter assembly
US6555062B1 (en) * 1991-03-04 2003-04-29 Bayer Corporation Reagent container for an automated analyzer
US20030087444A1 (en) * 2001-11-05 2003-05-08 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
US6649128B1 (en) * 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
US20060013729A1 (en) * 1991-02-14 2006-01-19 Glen Carey Fluid handling apparatus for an automated analyzer
US20060088443A1 (en) * 2004-10-22 2006-04-27 Beckman Coulter, Inc. Apparatus having improved gantry assembly suitable for use in a laboratory environment

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4117833C2 (en) 1991-05-29 1993-10-07 Medite Ges Fuer Medizintechnik Method and device for dyeing arranged on slides histological preparations
DE4117831C2 (en) 1991-05-29 1993-10-07 Medite Ges Fuer Medizintechnik Loading and unloading device for an apparatus for dyeing arranged on slides in slide racks histological preparations

Patent Citations (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1919169A (en) * 1931-06-05 1933-07-18 Western Union Telegraph Co Drag conveyer discharge
US3428027A (en) * 1967-07-24 1969-02-18 Badger Northland Inc Livestock feeding apparatus
US3691988A (en) * 1971-04-05 1972-09-19 Thermolyne Corp Apparatus for automatically staining microscope slides
US4152390A (en) * 1976-12-17 1979-05-01 Eastman Kodak Company Chemical analyzer
US4401020A (en) * 1981-12-16 1983-08-30 Seaco Industries Vegetable banding apparatus
US4401020B1 (en) * 1981-12-16 1985-10-08
US4756399A (en) * 1984-02-24 1988-07-12 Meccanizzazione Postale E Automazione S.P.A. Belt conveyor for the sorting of sundry articles
US4797258A (en) * 1984-11-10 1989-01-10 Mochida Pharmaceutical Co., Ltd. Chemical reaction apparatus
US4809842A (en) * 1985-09-04 1989-03-07 Nabisco Brands, Inc. Selective ejection conveyor
US4861553A (en) * 1987-06-11 1989-08-29 Technicon Instruments Corporation Automatic sampling system
US4911098A (en) * 1987-12-28 1990-03-27 Shiraimatsu & Co., Ltd. Automatic straining apparatus for slide specimens
US5209903A (en) * 1989-09-06 1993-05-11 Toa Medical Electronics, Co., Ltd. Synthetic apparatus for inspection of blood
US5356595A (en) * 1989-09-06 1994-10-18 Toa Medical Electronics Co., Ltd. Automated smear generator
US20060013729A1 (en) * 1991-02-14 2006-01-19 Glen Carey Fluid handling apparatus for an automated analyzer
US6555062B1 (en) * 1991-03-04 2003-04-29 Bayer Corporation Reagent container for an automated analyzer
US6387326B1 (en) * 1994-07-19 2002-05-14 Fisher Scientific Company L.L.C. Automated slide staining system and method thereof
US5909796A (en) * 1995-11-16 1999-06-08 Sandvik Ab Method and apparatus for loading articles onto vertically spaced platforms of a moving transport device
US6074617A (en) * 1998-07-10 2000-06-13 Bayer Corporation Stat shuttle adapter and transport device
US6358472B1 (en) * 1998-07-10 2002-03-19 Bayer Corporation Stat shuttle transport device
US6649128B1 (en) * 1998-09-23 2003-11-18 Randox Laboratories Ltd Assay device processing instrument
US6355487B2 (en) * 1999-04-16 2002-03-12 Pe Corporation (Ny) Apparatus and method for transferring small volumes of substances
US6227376B1 (en) * 1999-05-07 2001-05-08 Hormel Foods, Llc Two-directional reject and make-up conveyor system
US20020104736A1 (en) * 2001-02-02 2002-08-08 Peppel George W. Vertical diverter assembly
US20030087444A1 (en) * 2001-11-05 2003-05-08 Industrial Technology Research Institute Method and apparatus for manufacturing biochip
US20060088443A1 (en) * 2004-10-22 2006-04-27 Beckman Coulter, Inc. Apparatus having improved gantry assembly suitable for use in a laboratory environment

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050064535A1 (en) * 2002-12-20 2005-03-24 Dako Cytomation Denmark A/S Method and apparatus for pretreatment of tissue slides
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US7758809B2 (en) 2002-12-20 2010-07-20 Dako Cytomation Denmark A/S Method and system for pretreatment of tissue slides
US20080089808A1 (en) * 2006-10-17 2008-04-17 Preyas Sarabhai Shah Slide stainer with multiple heater stations
US7875242B2 (en) 2006-10-17 2011-01-25 Preyas Sarabhai Shah Slide stainer with multiple heater stations
WO2018072735A1 (en) * 2016-10-21 2018-04-26 陕西高源体外诊断试剂有限公司 Color-assisted interpretation device for frd epithelial tissue staining applicator

Also Published As

Publication number Publication date
US7198752B2 (en) 2007-04-03
DE20210451U1 (en) 2002-10-17

Similar Documents

Publication Publication Date Title
EP1546737B1 (en) Two-axis robot for specimen transfer
US6027691A (en) Automatic chemistry analyzer
US9029154B2 (en) Fill fluid for biological reaction apparatus with draining mechanism
US5736102A (en) Test sample positioning system
US4834944A (en) Automatic analytical apparatus
JP2909100B2 (en) analyzer
EP0597017B1 (en) Multi-linear automatic apparatus for processing immunoassays
CA1138227A (en) Method and apparatus for positioning cars in a sample handling apparatus
CN100413594C (en) Biological material deal device
US7331474B2 (en) Specimen-container rack for automated clinical instrument
AU719379B2 (en) A staining apparatus for staining of tissue specimens on microscope slides
EP0735358B1 (en) Automatic sample preparing apparatus
EP0410645A2 (en) Automated analytical apparatus and method
CA1296403C (en) Automated patient sample analysis instrument
US7028831B2 (en) Magnetic specimen-transport system for automated clinical instrument
US4298570A (en) Tray section for automated sample handling apparatus
US4803050A (en) Method and apparatus for liquid addition and aspiration in automated immunoassay techniques
US20040266015A1 (en) Automated sample processing apparatus and a method of automated treating of samples and use of such apparatus
US7678568B2 (en) Incubator
US6162399A (en) Universal apparatus for clinical analysis
CA2176053C (en) Method and apparatus for agglutination immunoassay
US7875241B2 (en) Specimen preparation apparatus, specimen preparation/analysis system and specimen plate
US6387326B1 (en) Automated slide staining system and method thereof
US6571934B1 (en) Bi-directional magnetic sample rack conveying system
US5234559A (en) Apparatus for direct blotting and automated electrophoresis, transfer and detection and processes utilizing the apparatus thereof

Legal Events

Date Code Title Description
AS Assignment

Owner name: LEICA MICROSYSTEMS NUSSLOCH GMBH, GERMANY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:THIEM, STEFAN;REEL/FRAME:014254/0750

Effective date: 20030512

AS Assignment

Owner name: LEICA BIOSYSTEMS NUSSLOCH GMBH, GERMANY

Free format text: CHANGE OF NAME;ASSIGNOR:LEICA MICROSYSTEMS NUSSLOCH GMBH;REEL/FRAME:019930/0254

Effective date: 20070719

Owner name: LEICA BIOSYSTEMS NUSSLOCH GMBH,GERMANY

Free format text: CHANGE OF NAME;ASSIGNOR:LEICA MICROSYSTEMS NUSSLOCH GMBH;REEL/FRAME:019930/0254

Effective date: 20070719

FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Expired due to failure to pay maintenance fee

Effective date: 20150403