US20030018362A1 - Ablation stent for treating atrial fibrillation - Google Patents

Ablation stent for treating atrial fibrillation Download PDF

Info

Publication number
US20030018362A1
US20030018362A1 US10123897 US12389702A US2003018362A1 US 20030018362 A1 US20030018362 A1 US 20030018362A1 US 10123897 US10123897 US 10123897 US 12389702 A US12389702 A US 12389702A US 2003018362 A1 US2003018362 A1 US 2003018362A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
stent
catheter
vein
ablation
left
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
US10123897
Other versions
US7209783B2 (en )
Inventor
Chris Fellows
Wade Bowe
David Wood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiac Pacemakers Inc
Original Assignee
Cardiac Pacemakers Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14Probes or electrodes therefor
    • A61B18/1492Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053Mechanical features of the instrument of device
    • A61B2018/00214Expandable means emitting energy, e.g. by elements carried thereon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00345Vascular system
    • A61B2018/00351Heart
    • A61B2018/00375Ostium, e.g. ostium of pulmonary vein or artery

Abstract

An apparatus and method for treating atrial fibrillation with ablation therapy in which a stent is deployed within a pulmonary vein and tissue surrounding the stent is ablated with radiofrequency energy to stop discharges from ectopic foci in the vein from reaching the left atrium. The deployed stent can then be left in place to prevent stenosis of the vein as well as allowing repeat ablation procedures as needed.

Description

    CROSS-REFERENCE TO RELATED APPLICATION(S)
  • [0001]
    This application claims the benefit of U.S. Provisional Application No. 60/298,738, filed on Jun. 15, 2001, under 35 U.S.C. 119(e).
  • FIELD OF THE INVENTION
  • [0002]
    This invention pertains to methods for treating atrial tachyarrhythmias such as atrial fibrillation. In particular, the invention relates to an apparatus and method for treating atrial fibrillation by ablation therapy.
  • BACKGROUND
  • [0003]
    Fibrillation refers to a condition in which muscle fibrils enter a state of extremely rapid, small-scale contractions that do not coordinate to effect contraction of the muscle as a whole. When this occurs in the left ventricle, the heart chamber responsible for pumping blood into the arterial vasculature, it is serious and rapidly fatal. When it occurs in the musculature of the atria, it is less immediately serious and not necessarily fatal. It is still important to treat atrial fibrillation, however, for several reasons. First, atrial fibrillation is associated with a loss of atrio-ventricular synchrony which can be hemodynamically compromising and cause such symptoms as dyspnea, fatigue, vertigo, and angina. Atrial fibrillation can also predispose to strokes resulting from emboli forming in the left atrium. Although drug therapy, in-hospital cardioversion, and implantable cardioverter/defibrillators are acceptable treatment modalities for atrial fibrillation, a curative approach such as ablation therapy offers a number of advantages to certain patients, including convenience and greater efficacy.
  • [0004]
    Electrical ablation therapy treats cardiac arrhythmias by destroying myocardial tissue involved in the initiation or maintenance of the tachyarrhythmia. Ablation is most often accomplished by delivering radiofrequency electrical energy through a catheter electrode that has been placed next to the tissue to be destroyed. One way that the technique has been employed in order to treat atrial fibrillation is to identify ectopic sites or reentrant pathways electrophysiologically and then eliminate them by radiofrequency catheter ablation. Recent evidence has shown that the great majority of paroxysms of atrial fibrillation are initiated by trains of rapid discharges originating from the pulmonary veins. Accordingly, catheter techniques have been developed for ablating these sites with radiofrequency energy applied from within the pulmonary veins, but electrophysiological mapping of such sites is difficult. Alternatively, another technique involves the production of a circumferential ablation lesion within a pulmonary vein in order to block the conduction pathway from the vein to the left atrium. An effective circumferential lesion must be completely continuous, however, and this means that the ablation device must be precisely located within the vein or ostium, which may be difficult to accomplish. Furthermore, a common complication of this procedure is pulmonary venous stenosis resulting from scarring within the pulmonary vein which has variable clinical consequences.
  • SUMMARY OF THE INVENTION
  • [0005]
    An objective of the present invention is to provide an improved apparatus and method for pulmonary vein ablation in order to treat atrial fibrillation. In accordance with the invention, a stent catheter having a stent mounted thereon is introduced into the left atrium of a patient. The stent is deployed by expansion of the stent within a pulmonary vein or ostium of the vein. The stent expansion may be performed with a balloon at the distal end of the stent catheter or by a self-expanding stent. Tissue surrounding the deployed stent is then ablated to stop discharges from ectopic foci in the vein from reaching the left atrium. After the ablation, the stent is left in place in order to prevent stenosis of the vein.
  • [0006]
    In order to produce the ablation, radiofrequency energy is transmitted into the surrounding tissue by means of a catheter making contact with the stent which then causes heating of the surrounding tissue. The stent may have electrodes for transmitting current to the surrounding tissue or the stent itself may be used as an electrode. The ablation lesions in the tissue surrounding the stent may be selectively produced so as to destroy one or more ectopic foci, or a circumferential lesion may be produced that interrupts a conduction pathway between the vein and the left atrium.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0007]
    [0007]FIG. 1A depicts a stent catheter with a stent mounted at one end.
  • [0008]
    [0008]FIG. 1B shows a balloon catheter with an electrode for delivering energy to a deployed stent.
  • [0009]
    [0009]FIG. 2A shows one embodiment of a stent with annular electrodes.
  • [0010]
    [0010]FIG. 2B shows an embodiment of a stent with a plurality of patch electrodes.
  • [0011]
    FIGS. 3A-3D depict the steps in one method for forming an electrode on the surface of a stent.
  • [0012]
    [0012]FIG. 4 shows another embodiment of a stent with structures for preventing dislodgement after the stent is deployed.
  • [0013]
    [0013]FIG. 5 shows a stent with temperature sensing elements.
  • DETAILED DESCRIPTION OF THE INVENTION
  • [0014]
    As noted above, it has been found that the ectopic foci responsible for most episodes of atrial fibrillation are found in the pulmonary veins. The pulmonary veins empty into the left atrium, and a myocardial muscle sleeve extends over the proximal segment of the veins. The myocytes in these pulmonary vein sleeves, unlike ordinary atrial myocytes, exhibit spontaneous activity and can thus constitute ectopic sites responsible for initiating and maintaining atrial fibrillation. In order to block the discharges from these myocytes with ablation therapy, either the myocytes themselves are destroyed or an ablation lesion is made that destroys excitable tissue in the pathway leading from the myocytes to the left atrium.
  • [0015]
    Shown in FIG. 1A is a depiction of a stent catheter 100 having a balloon 120 at its distal end. Fitted around the balloon 120 is a vascular stent 110, which is a tubular structure made of metal or synthetic material capable of being deployed in a pulmonary vein similar to the way arterial stents are deployed in peripheral or coronary arteries. Pressurized fluid applied to the proximal end of the catheter passes through a lumen within the catheter and inflates the balloon 120. Inflating the balloon 120 expands the stent 110 against the walls of a blood vessel and thereby deploys the stent in a fixed position within the vessel. In an alternate embodiment, the stent may be designed to be self-expanding such as by mechanical means or by being constructed of a shape-memory alloy such as nitinol.
  • [0016]
    The stent catheter 100 with the stent 110 fixed thereon may be positioned in a pulmonary vein using an over the wire catheterization technique in which a radio-opaque catheter, or guidewire over which the catheter slides, is passed into a patient's vascular system under fluoroscopic guidance. Vascular access is obtained by puncturing a vessel and seating a hemostatic valve within the puncture wound. The stent catheter is then passed into the patient's vascular system through the valve. In one approach, the catheter is introduced into a peripheral vein and then advanced through the vena cava and into the right atrium. From there, the catheter is positioned against the fossa ovalis in the atrial septum, and a needle or trochar is advanced distally through a lumen of the stent catheter and out the distal end to puncture the fossa ovalis. The catheter is then passed through the atrial septum to reach the left atrium and gain access to the pulmonary veins. In another approach, the catheter is advanced into the left atrium from the arterial system by accessing a peripheral artery and advancing the catheter into the aorta, around the aortic arch, into the left ventricle, and then into the left atrium through the mitral valve. With either approach, after reaching the left atrium, the distal end of the stent catheter 100 is advanced into a selected pulmonary vein to position the stent 110 within either the vein or the ostium of the vein where the conduction block is to be formed. Alternatively, the stent deployment could be done during open-heart surgery or a transthoracic surgical procedure. In that case, rather than a catheter, a plunger-type instrument could be used to deploy the stent and apply energy thereto to produce the ablation lesion. Saline infusion for cooling could also be applied through the plunger type instrument.
  • [0017]
    The stent 110 is deployed by expanding the stent within the vein by, for example, inflating balloon 120 over which the stent 110 is fitted. Tissue surrounding the deployed stent is then ablated so as to stop discharges from ectopic foci in the vein from reaching the left atrium. The ablation lesions in the tissue surrounding the stent may be selectively produced so as to destroy one or more ectopic foci, or a circumferential lesion may be produced that interrupts a conduction pathway between the vein and the left atrium. After the ablation lesion has been produced, the stent is left in place in order to prevent stenosis of the vein as a result of fibrosis and scarring.
  • [0018]
    In order to produce the ablation lesion, radiofrequency energy is applied to the stent which causes thermal heating of the surrounding tissue. The result is either a circumferential conduction block around the vein which isolates myocytes in the vein distal to the lesion or localized destruction of ectopic foci. Such energy can be applied from the stent catheter or from a separately introduced ablation catheter which contacts the stent and transmits electrical energy thereto. FIG. 1B shows an embodiment of a stent catheter 100 in which an electrode 121 is mounted on the balloon 120. The electrode 121 is connected internal to the balloon to a conductor 101 that extends through the lumen of the catheter so that electrical energy can be applied to the electrode. With either a catheter such as that shown in FIG. 1B or a separate ablation catheter, radiofrequency energy is transmitted from the catheter to the stent which either acts as an electrode or has separate ablation electrodes mounted thereon as described below.
  • [0019]
    The stent itself may be used as an electrode or may have separate electrodes for transmitting current to the surrounding tissue. In the former case, the stent may be made of any electrically conductive material such as platinum, silver, gold, stainless steel, nitinol, or titanium. FIG. 2A shows an exemplary stent design in which the stent 110 has one or more annular electrodes 111 mounted thereon which effect a cirumferential burn when radiofrequency energy is applied to the electrodes. Preferably, the annular electrodes are constructed so as to produce a circumferentially continuous lesion when electrical energy is applied. FIG. 2B shows another embodiment in which the stent 110 has one or more patch electrodes 112 placed at selected locations on the surface of the stent. Such patch electrodes are electrically conductive areas on the stent surface which may be of any desired shape.
  • [0020]
    Separate electrodes on the stent may be of the same material or a separate material which may be formed on the stent by, for example, sputter coating or vapor deposition. FIGS. 3A through 3D show one method for making an annular electrode on a stent. FIG. 3A shows a stent 110 made of electrically conductive material. An annular mask 200 is then applied to the stent 110 at the location where an electrode is desired as shown in FIG. 3B. Next, a non-conductive dielectric coating 201 is applied to the entire stent as shown in FIG. 3C. FIG. 3D shows the resulting stent with an electrically conductive annular electrode 113 after the mask is removed.
  • [0021]
    In order to reduce the risk of thrombus formation, a coating of heparin or other anti-coagulant can be applied to the stent before deployment. In addition, mechanical anchoring devices may be incorporated into the stent in order to prevent dislodgement after the stent is deployed. FIG. 4 illustrates one example of such a stent in which a plurality of hooks 114 are mounted on a stent 110. The hooks 114 are oriented so as to allow the stent to be pushed retrogradely through a pulmonary vein without resistance but prevent it from being pushed out in the other direction by blood flow. Other anchoring devices mounted on the stent, such as tines, spikes, or barbs, may similarly be employed to fix the stent in place after deployment.
  • [0022]
    During the ablation procedure, it may be useful to monitor the temperature of the tissue as it is heated by the ablation electrodes. Accordingly, FIG. 5 illustrates a modified ablation stent 110 with ablation electrodes 112 and which also has one or more temperature sensors 115 mounted thereon. The temperature sensors (e.g., thermocouples or resistive temperature devices) are connected via a conductor running through the catheter to monitoring equipment at the proximal end of the catheter in order to provide feedback to an operator as current is supplied to the ablation electrodes.
  • [0023]
    As described above, using a deployed vascular stent as a vehicle for delivering ablation energy to a selected location greatly facilitates the ablation procedure and produces more consistent results. In the event a first ablation procedure is not satisfactory, however, having the stent already deployed also allows any repeat ablation procedures to be more easily performed.
  • [0024]
    Although the invention has been described in conjunction with the foregoing specific embodiment, many alternatives, variations, and modifications will be apparent to those of ordinary skill in the art. Such alternatives, variations, and modifications are intended to fall within the scope of the following appended claims.

Claims (19)

    What is claimed is:
  1. 1. A method for treating atrial fibrillation, comprising:
    introducing a stent into the left atrium of a patient;
    deploying the stent into a pulmonary vein;
    applying radiofrequency energy to the deployed stent in order to ablate surrounding tissue and stop discharges from ectopic foci in the vein from reaching the left atrium; and,
    leaving the stent in place in order to prevent stenosis of the vein.
  2. 2. The method of claim 1 wherein the stent is introduced by a stent catheter having a stent mounted at its distal end.
  3. 3. The method of claim 2 further comprising inflating a balloon at the distal end of the stent catheter to expand the stent within a pulmonary vein.
  4. 4. The method of claim 1 further comprising transmitting the radiofrequency energy into the surrounding tissue by means of a catheter making contact with the stent.
  5. 5. The method of claim 3 further comprising transmitting the radiofrequency energy to the stent by an electrode mounted on the surface of the balloon.
  6. 6. The method of claim 1 where in t he stent acts as an electrode when radiofrequency energy is applied thereto so that tissue surrounding the stent is ablated and forms a circumferential lesion that interrupts a conduction pathway between the vein and the left atrium.
  7. 7. The method of claim 1 wherein radiofrequency energy is applied to electrodes mounted on the stent to thereby ablate tissue in contact with the electrodes.
  8. 8. The method of claim 1 wherein the stent has one or more anchoring devices mounted thereon that serve to prevent dislodgment after the stent is deployed in a pulmonary vein.
  9. 9. The method of claim 1 further comprising coating the stent with an anti-coagulant to prevent thrombus formation.
  10. 10. The method of claim 1 further comprising performing one or more additional ablation procedures after the stent is deployed by applying radiofrequency energy to the deployed stent if a first ablation procedure did not produce satisfactory results.
  11. 11. The method of claim 1 further comprising advancing the stent catheter transvenously into the left atrium through the atrial septum.
  12. 12. An apparatus for treating atrial fibrillation, comprising:
    a stent catheter having a stent mounted thereon for deployment in a pulmonary vein, the catheter including a balloon at its distal end for expanding the stent within a pulmonary vein; and,
    an electrode for transmitting radiofrequency energy to the deployed stent in order to ablate surrounding tissue and stop discharges from ectopic foci in the vein from reaching the left atrium.
  13. 13. The apparatus of claim 12 wherein the balloon further comprises an electrode on the surface of the balloon for making contact with the deployed stent and transmitting energy thereto.
  14. 14. The apparatus of claim 12 further comprising one or more electrodes mounted on the stent for contacting surrounding tissue and producing an ablation lesion when energy is applied thereto.
  15. 15. The apparatus of claim 13 wherein the stent electrode is an annular electrode.
  16. 16. The apparatus of claim 13 wherein the stent electrode is a patch electrode.
  17. 17. The apparatus of claim 13 wherein the stent is constructed of an electrically conductive material and further wherein a dielectric coating is applied to the outer surface of the stent leaving a selected area exposed to serve as an electrode.
  18. 18. The apparatus of claim 12 further comprising one or more anchoring devices mounted on the surface of the stent to prevent dislodgement after the stent is deployed.
  19. 19. The apparatus of claim 12 wherein the stent is coated with an anti-coagulant to prevent thrombus formation.
US10123897 2001-06-15 2002-04-16 Ablation stent for treating atrial fibrillation Expired - Fee Related US7209783B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US29873801 true 2001-06-15 2001-06-15
US10123897 US7209783B2 (en) 2001-06-15 2002-04-16 Ablation stent for treating atrial fibrillation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10123897 US7209783B2 (en) 2001-06-15 2002-04-16 Ablation stent for treating atrial fibrillation

Publications (2)

Publication Number Publication Date
US20030018362A1 true true US20030018362A1 (en) 2003-01-23
US7209783B2 US7209783B2 (en) 2007-04-24

Family

ID=26822012

Family Applications (1)

Application Number Title Priority Date Filing Date
US10123897 Expired - Fee Related US7209783B2 (en) 2001-06-15 2002-04-16 Ablation stent for treating atrial fibrillation

Country Status (1)

Country Link
US (1) US7209783B2 (en)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030069606A1 (en) * 2001-06-15 2003-04-10 Girouard Steven D. Pulmonary vein stent for treating atrial fibrillation
US20040106952A1 (en) * 2002-12-03 2004-06-03 Lafontaine Daniel M. Treating arrhythmias by altering properties of tissue
US20040153139A1 (en) * 1999-10-13 2004-08-05 Biocardia, Inc. Pulmonary vein stent and method for use
US20040167598A1 (en) * 2002-11-08 2004-08-26 Margolis James R. Device and method for electrical isolation of the pulmonary veins
US20040220560A1 (en) * 2003-04-29 2004-11-04 Briscoe Roderick E. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US20040220655A1 (en) * 2003-03-03 2004-11-04 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
US20060020271A1 (en) * 2004-06-18 2006-01-26 Stewart Mark T Methods and devices for occlusion of an atrial appendage
US20060089709A1 (en) * 2004-10-21 2006-04-27 Helmus Michael N Medical implant with average surface charge density
US20060116666A1 (en) * 2004-10-08 2006-06-01 Sinus Rhythm Technologies, Inc. Two-stage scar generation for treating atrial fibrillation
US20060178725A1 (en) * 2004-03-02 2006-08-10 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
US20070239252A1 (en) * 2006-04-10 2007-10-11 Medtronic Vascular, Inc. A Mechanism to Ensure Placement of Ostial Renal Stents
US7645285B2 (en) 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US20100179570A1 (en) * 2009-01-13 2010-07-15 Salvatore Privitera Apparatus and methods for deploying a clip to occlude an anatomical structure
US20100222786A1 (en) * 2003-02-21 2010-09-02 Kassab Ghassan S Devices, systems, and methods for removing targeted lesions from vessels
US8257376B2 (en) 2003-11-17 2012-09-04 Syntach Ag Device, a kit and a method for treatment of disorders in the heart rhythm regulation system
US20130090651A1 (en) * 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
CN103385754A (en) * 2012-05-09 2013-11-13 韦伯斯特生物官能(以色列)有限公司 Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
US8636754B2 (en) 2010-11-11 2014-01-28 Atricure, Inc. Clip applicator
US20140031785A1 (en) * 2011-04-01 2014-01-30 Flux Medical N.V. System, device and method for ablation of a vessel's wall from the inside
CN104519837A (en) * 2012-05-18 2015-04-15 太雄医疗器株式会社 Combined cauterization and stent operation device
US9017349B2 (en) 2010-10-27 2015-04-28 Atricure, Inc. Appendage clamp deployment assist device
US9066741B2 (en) 2010-11-01 2015-06-30 Atricure, Inc. Robotic toolkit
US9265486B2 (en) 2011-08-15 2016-02-23 Atricure, Inc. Surgical device
US9282973B2 (en) 2012-01-20 2016-03-15 Atricure, Inc. Clip deployment tool and associated methods
US9408659B2 (en) 2007-04-02 2016-08-09 Atricure, Inc. Surgical instrument with separate tool head and method of use
US9526572B2 (en) 2011-04-26 2016-12-27 Aperiam Medical, Inc. Method and device for treatment of hypertension and other maladies
US9656063B2 (en) 2004-06-18 2017-05-23 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US9782213B2 (en) 2012-05-18 2017-10-10 Starmed Co., Ltd. Overlapping bipolar electrode for high-frequency heat treatment

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7054690B2 (en) * 2003-10-22 2006-05-30 Intrapace, Inc. Gastrointestinal stimulation device
US7056286B2 (en) 2003-11-12 2006-06-06 Adrian Ravenscroft Medical device anchor and delivery system
WO2006045075A1 (en) * 2004-10-20 2006-04-27 Boston Scientific Limited Leadless cardiac stimulation systems
US7532933B2 (en) * 2004-10-20 2009-05-12 Boston Scientific Scimed, Inc. Leadless cardiac stimulation systems
US7650186B2 (en) * 2004-10-20 2010-01-19 Boston Scientific Scimed, Inc. Leadless cardiac stimulation systems
JP2009518115A (en) * 2005-12-09 2009-05-07 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Heart stimulation system
US8050774B2 (en) * 2005-12-22 2011-11-01 Boston Scientific Scimed, Inc. Electrode apparatus, systems and methods
EP2018139B1 (en) * 2006-04-26 2017-03-01 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
US9480552B2 (en) 2006-04-26 2016-11-01 The Cleveland Clinic Foundation Apparatus and method for treating cardiovascular diseases
US7840281B2 (en) * 2006-07-21 2010-11-23 Boston Scientific Scimed, Inc. Delivery of cardiac stimulation devices
US8290600B2 (en) * 2006-07-21 2012-10-16 Boston Scientific Scimed, Inc. Electrical stimulation of body tissue using interconnected electrode assemblies
WO2008034005A3 (en) * 2006-09-13 2008-07-10 Boston Scient Scimed Inc Cardiac stimulation using leadless electrode assemblies
WO2009099550A1 (en) * 2008-02-07 2009-08-13 Cardiac Pacemakers, Inc. Wireless tissue electrostimulation
US9649211B2 (en) 2009-11-04 2017-05-16 Confluent Medical Technologies, Inc. Alternating circumferential bridge stent design and methods for use thereof
JP2014516608A (en) * 2011-03-31 2014-07-17 ティダル ウェーブ テクノロジー、インコーポレイテッド High-frequency ablation catheter device
US20130231658A1 (en) * 2012-03-01 2013-09-05 Boston Scientific Scimed, Inc. Expandable ablation device and methods for nerve modulation
US8934988B2 (en) 2012-03-16 2015-01-13 St. Jude Medical Ab Ablation stent with meander structure

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6443949B1 (en) *
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4281664A (en) * 1979-05-14 1981-08-04 Medtronic, Inc. Implantable telemetry transmission system for analog and digital data
US4299220A (en) * 1979-05-03 1981-11-10 The Regents Of The University Of Minnesota Implantable drug infusion regulator
US4544371A (en) * 1982-10-05 1985-10-01 American Hospital Supply Corporation Implantable metered dose drug delivery system
US4556063A (en) * 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
US4686987A (en) * 1981-06-18 1987-08-18 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiologic demand
US4871351A (en) * 1984-09-28 1989-10-03 Vladimir Feingold Implantable medication infusion system
US4944299A (en) * 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
US4987897A (en) * 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5040533A (en) * 1989-12-29 1991-08-20 Medical Engineering And Development Institute Incorporated Implantable cardiovascular treatment device container for sensing a physiological parameter
US5042497A (en) * 1990-01-30 1991-08-27 Cardiac Pacemakers, Inc. Arrhythmia prediction and prevention for implanted devices
US5058581A (en) * 1990-02-20 1991-10-22 Siemens-Pacesetter, Inc. Telemetry apparatus and method for implantable tissue stimulator
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
US5127404A (en) * 1990-01-22 1992-07-07 Medtronic, Inc. Telemetry format for implanted medical device
US5190035A (en) * 1981-06-18 1993-03-02 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiological demand
US5220917A (en) * 1989-11-24 1993-06-22 Leonardo Cammilli Implantable pharmacological defibrillator with automatic recognition of ventricular fibrillation
US5269301A (en) * 1987-10-06 1993-12-14 Leonard Bloom Multimode system for monitoring and treating a malfunctioning heart
US5284136A (en) * 1990-04-04 1994-02-08 Cardiac Pacemakers, Inc. Dual indifferent electrode pacemaker
US5305745A (en) * 1988-06-13 1994-04-26 Fred Zacouto Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemopathies and the presence of abnormal elements in the blood
US5342408A (en) * 1993-01-07 1994-08-30 Incontrol, Inc. Telemetry system for an implantable cardiac device
US5353800A (en) * 1992-12-11 1994-10-11 Medtronic, Inc. Implantable pressure sensor lead
US5368028A (en) * 1989-08-11 1994-11-29 Cb-Carmel Biotechnology Ltd. System for monitoring and controlling blood and tissue constituent levels
US5404877A (en) * 1993-06-04 1995-04-11 Telectronics Pacing Systems, Inc. Leadless implantable sensor assembly and a cardiac emergency warning alarm
US5416395A (en) * 1990-09-21 1995-05-16 Canon Kabushiki Kaisha Carriage drive control for a printer
US5456692A (en) * 1993-09-03 1995-10-10 Pacesetter, Inc. System and method for noninvasively altering the function of an implanted pacemaker
US5460605A (en) * 1988-02-19 1995-10-24 Gensia, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
US5496360A (en) * 1994-04-12 1996-03-05 Ventritex, Inc. Implantable cardiac electrode with rate controlled drug delivery
US5499971A (en) * 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5551953A (en) * 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
US5556421A (en) * 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
US5562713A (en) * 1995-01-18 1996-10-08 Pacesetter, Inc. Bidirectional telemetry apparatus and method for implantable device
US5579876A (en) * 1994-10-15 1996-12-03 August Bilstein Gmbh & Co. Kg Stopper for a hydraulic dashpot
US5586556A (en) * 1995-05-11 1996-12-24 T Z Medical, Inc. Pacemaker and heart monitoring and data transmitting device and method
US5607418A (en) * 1995-08-22 1997-03-04 Illinois Institute Of Technology Implantable drug delivery apparatus
US5607463A (en) * 1993-03-30 1997-03-04 Medtronic, Inc. Intravascular medical device
US5634899A (en) * 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5662689A (en) * 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
US5690682A (en) * 1996-06-17 1997-11-25 Pharmatarget, Inc. Device and method for treatment of cardiac arrhythmia
US5693075A (en) * 1993-10-05 1997-12-02 Sorin Biomedica S.P.A. Device for determining myocardial function and corresponding procedure
US5720770A (en) * 1995-10-06 1998-02-24 Pacesetter, Inc. Cardiac stimulation system with enhanced communication and control capability
US5800498A (en) * 1996-04-26 1998-09-01 Pharmatarget, Inc. Catheter for implantable rhythm control device
US5814089A (en) * 1996-12-18 1998-09-29 Medtronic, Inc. Leadless multisite implantable stimulus and diagnostic system
US5833603A (en) * 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US5836935A (en) * 1994-11-10 1998-11-17 Ashton; Paul Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5899928A (en) * 1996-05-14 1999-05-04 Pacesetter, Inc. Descriptive transtelephonic pacing intervals for use by an emplantable pacemaker
US5925066A (en) * 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5949659A (en) * 1995-05-02 1999-09-07 Siemens Ag Galvanically isolated transmission of power and information to an electronic unit
US5954761A (en) * 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US5967986A (en) * 1997-11-25 1999-10-19 Vascusense, Inc. Endoluminal implant with fluid flow sensing capability
US5980566A (en) * 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US5980563A (en) * 1998-08-31 1999-11-09 Tu; Lily Chen Ablation apparatus and methods for treating atherosclerosis
US5991668A (en) * 1997-09-25 1999-11-23 Medtronic, Inc. Medical electrical lead
US6016447A (en) * 1998-10-27 2000-01-18 Medtronic, Inc. Pacemaker implant recognition
US6016448A (en) * 1998-10-27 2000-01-18 Medtronic, Inc. Multilevel ERI for implantable medical devices
US6024740A (en) * 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US6115636A (en) * 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6141588A (en) * 1998-07-24 2000-10-31 Intermedics Inc. Cardiac simulation system having multiple stimulators for anti-arrhythmia therapy
US6154675A (en) * 1998-10-27 2000-11-28 Medtronic, Inc. Resetting ERI/POR/PIR/indicators in implantable medical devices
US6168801B1 (en) * 1998-09-09 2001-01-02 Cardiac Pacemakers, Inc. Controlled release drug delivery
US6179789B1 (en) * 1999-05-03 2001-01-30 Lily Chen Tu Enhanced radioactive stent for reduction of restenosis
US6198394B1 (en) * 1996-12-05 2001-03-06 Stephen C. Jacobsen System for remote monitoring of personnel
US6200265B1 (en) * 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6231516B1 (en) * 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
US6237398B1 (en) * 1997-12-30 2001-05-29 Remon Medical Technologies, Ltd. System and method for monitoring pressure, flow and constriction parameters of plumbing and blood vessels
US6251109B1 (en) * 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
US6254573B1 (en) * 1998-02-05 2001-07-03 Biosense, Inc. Intracardiac drug delivery device utilizing spring-loaded mechanism
US6277078B1 (en) * 1999-11-19 2001-08-21 Remon Medical Technologies, Ltd. System and method for monitoring a parameter associated with the performance of a heart
US6298272B1 (en) * 1999-03-29 2001-10-02 Cardiac Pacemakers, Inc. High impedance electrode tip with internal drug delivery capability
US6317615B1 (en) * 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US20020026228A1 (en) * 1999-11-30 2002-02-28 Patrick Schauerte Electrode for intravascular stimulation, cardioversion and/or defibrillation
US6358202B1 (en) * 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US6361780B1 (en) * 1998-11-12 2002-03-26 Cardiac Pacemakers, Inc. Microporous drug delivery system
US6361522B1 (en) * 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US6424847B1 (en) * 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
US6442413B1 (en) * 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US6443949B2 (en) * 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6453195B1 (en) * 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
US6459917B1 (en) * 2000-05-22 2002-10-01 Ashok Gowda Apparatus for access to interstitial fluid, blood, or blood plasma components
US6501983B1 (en) * 1998-08-07 2002-12-31 Infinite Biomedical Technologies, Llc Implantable myocardial ischemia detection, indication and action technology
US20030004403A1 (en) * 2001-06-29 2003-01-02 Darrel Drinan Gateway platform for biological monitoring and delivery of therapeutic compounds
US6511477B2 (en) * 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6514249B1 (en) * 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
US6519245B1 (en) * 1999-01-11 2003-02-11 Trimble Navigation Limited Communication system having dedicated time slots for selection signals
US6518245B1 (en) * 1997-01-31 2003-02-11 The Board Of Trustees Of The Leland Stanford Jr. University Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase
US6542781B1 (en) * 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US20030069606A1 (en) * 2001-06-15 2003-04-10 Girouard Steven D. Pulmonary vein stent for treating atrial fibrillation
US20030158584A1 (en) * 2002-02-19 2003-08-21 Cates Adam W Chronically-implanted device for sensing and therapy
US6632223B1 (en) * 2000-03-30 2003-10-14 The General Hospital Corporation Pulmonary vein ablation stent and method
US6645145B1 (en) * 1998-11-19 2003-11-11 Siemens Medical Solutions Usa, Inc. Diagnostic medical ultrasound systems and transducers utilizing micro-mechanical components
US6716242B1 (en) * 1999-10-13 2004-04-06 Peter A. Altman Pulmonary vein stent and method for use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3046802A1 (en) 1980-12-12 1982-07-15 Basf Ag Ethylene-alkyne copolymers which erdoeldestillaten to their preparation and use as additive
EP0346802A1 (en) 1988-06-17 1989-12-20 Pier Luigi Spalla Multipurpose and self-moving agricultural machine
US5416695A (en) 1993-03-09 1995-05-16 Metriplex, Inc. Method and apparatus for alerting patients and medical personnel of emergency medical situations
US5944659A (en) 1995-11-13 1999-08-31 Vitalcom Inc. Architecture for TDMA medical telemetry system
US6140740A (en) 1997-12-30 2000-10-31 Remon Medical Technologies, Ltd. Piezoelectric transducer
WO2001078835A1 (en) * 2000-04-13 2001-10-25 Uab Research Foundation Inter-atrial septum electrode for atrial defibrillation

Patent Citations (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179789B2 (en) *
US6443949B1 (en) *
US3692027A (en) * 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US4299220A (en) * 1979-05-03 1981-11-10 The Regents Of The University Of Minnesota Implantable drug infusion regulator
US4281664A (en) * 1979-05-14 1981-08-04 Medtronic, Inc. Implantable telemetry transmission system for analog and digital data
US4556063A (en) * 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
US4686987A (en) * 1981-06-18 1987-08-18 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiologic demand
US5190035A (en) * 1981-06-18 1993-03-02 Cardiac Pacemakers, Inc. Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiological demand
US4544371A (en) * 1982-10-05 1985-10-01 American Hospital Supply Corporation Implantable metered dose drug delivery system
US4871351A (en) * 1984-09-28 1989-10-03 Vladimir Feingold Implantable medication infusion system
US5269301A (en) * 1987-10-06 1993-12-14 Leonard Bloom Multimode system for monitoring and treating a malfunctioning heart
US5460605A (en) * 1988-02-19 1995-10-24 Gensia, Inc. Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist
US5305745A (en) * 1988-06-13 1994-04-26 Fred Zacouto Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemopathies and the presence of abnormal elements in the blood
US4944299A (en) * 1989-08-08 1990-07-31 Siemens-Pacesetter, Inc. High speed digital telemetry system for implantable device
US5368028A (en) * 1989-08-11 1994-11-29 Cb-Carmel Biotechnology Ltd. System for monitoring and controlling blood and tissue constituent levels
US4987897A (en) * 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US5041107A (en) * 1989-10-06 1991-08-20 Cardiac Pacemakers, Inc. Electrically controllable, non-occluding, body implantable drug delivery system
US5220917A (en) * 1989-11-24 1993-06-22 Leonardo Cammilli Implantable pharmacological defibrillator with automatic recognition of ventricular fibrillation
US5040533A (en) * 1989-12-29 1991-08-20 Medical Engineering And Development Institute Incorporated Implantable cardiovascular treatment device container for sensing a physiological parameter
US5127404A (en) * 1990-01-22 1992-07-07 Medtronic, Inc. Telemetry format for implanted medical device
US5042497A (en) * 1990-01-30 1991-08-27 Cardiac Pacemakers, Inc. Arrhythmia prediction and prevention for implanted devices
US5058581A (en) * 1990-02-20 1991-10-22 Siemens-Pacesetter, Inc. Telemetry apparatus and method for implantable tissue stimulator
US5284136A (en) * 1990-04-04 1994-02-08 Cardiac Pacemakers, Inc. Dual indifferent electrode pacemaker
US5499971A (en) * 1990-06-15 1996-03-19 Cortrak Medical, Inc. Method for iontophoretically delivering drug adjacent to a heart
US5087243A (en) * 1990-06-18 1992-02-11 Boaz Avitall Myocardial iontophoresis
US5416395A (en) * 1990-09-21 1995-05-16 Canon Kabushiki Kaisha Carriage drive control for a printer
US5353800A (en) * 1992-12-11 1994-10-11 Medtronic, Inc. Implantable pressure sensor lead
US5342408A (en) * 1993-01-07 1994-08-30 Incontrol, Inc. Telemetry system for an implantable cardiac device
US5607463A (en) * 1993-03-30 1997-03-04 Medtronic, Inc. Intravascular medical device
US5404877A (en) * 1993-06-04 1995-04-11 Telectronics Pacing Systems, Inc. Leadless implantable sensor assembly and a cardiac emergency warning alarm
US5634899A (en) * 1993-08-20 1997-06-03 Cortrak Medical, Inc. Simultaneous cardiac pacing and local drug delivery method
US5456692A (en) * 1993-09-03 1995-10-10 Pacesetter, Inc. System and method for noninvasively altering the function of an implanted pacemaker
US5693075A (en) * 1993-10-05 1997-12-02 Sorin Biomedica S.P.A. Device for determining myocardial function and corresponding procedure
US5496360A (en) * 1994-04-12 1996-03-05 Ventritex, Inc. Implantable cardiac electrode with rate controlled drug delivery
US5579876A (en) * 1994-10-15 1996-12-03 August Bilstein Gmbh & Co. Kg Stopper for a hydraulic dashpot
US5551953A (en) * 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
US5836935A (en) * 1994-11-10 1998-11-17 Ashton; Paul Implantable refillable controlled release device to deliver drugs directly to an internal portion of the body
US5562713A (en) * 1995-01-18 1996-10-08 Pacesetter, Inc. Bidirectional telemetry apparatus and method for implantable device
US5556421A (en) * 1995-02-22 1996-09-17 Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
US5730125A (en) * 1995-02-22 1998-03-24 Sulzer Intermedics, Inc. Implantable medical device with enclosed physiological parameter sensors or telemetry link
US5949659A (en) * 1995-05-02 1999-09-07 Siemens Ag Galvanically isolated transmission of power and information to an electronic unit
US5586556A (en) * 1995-05-11 1996-12-24 T Z Medical, Inc. Pacemaker and heart monitoring and data transmitting device and method
US5607418A (en) * 1995-08-22 1997-03-04 Illinois Institute Of Technology Implantable drug delivery apparatus
US5893881A (en) * 1995-09-08 1999-04-13 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain by delivering a bolus of analgesic
US5817131A (en) * 1995-09-08 1998-10-06 Medtronic, Inc. Method and apparatus for alleviating cardoversion shock pain
US5662689A (en) * 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
US5720770A (en) * 1995-10-06 1998-02-24 Pacesetter, Inc. Cardiac stimulation system with enhanced communication and control capability
US5925066A (en) * 1995-10-26 1999-07-20 Galvani, Ltd. Atrial arrythmia sensor with drug and electrical therapy control apparatus
US5833603A (en) * 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
US5800498A (en) * 1996-04-26 1998-09-01 Pharmatarget, Inc. Catheter for implantable rhythm control device
US5899928A (en) * 1996-05-14 1999-05-04 Pacesetter, Inc. Descriptive transtelephonic pacing intervals for use by an emplantable pacemaker
US5690682A (en) * 1996-06-17 1997-11-25 Pharmatarget, Inc. Device and method for treatment of cardiac arrhythmia
US6198394B1 (en) * 1996-12-05 2001-03-06 Stephen C. Jacobsen System for remote monitoring of personnel
US5814089A (en) * 1996-12-18 1998-09-29 Medtronic, Inc. Leadless multisite implantable stimulus and diagnostic system
US6518245B1 (en) * 1997-01-31 2003-02-11 The Board Of Trustees Of The Leland Stanford Jr. University Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase
US6511477B2 (en) * 1997-03-13 2003-01-28 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US6443949B2 (en) * 1997-03-13 2002-09-03 Biocardia, Inc. Method of drug delivery to interstitial regions of the myocardium
US5954761A (en) * 1997-03-25 1999-09-21 Intermedics Inc. Implantable endocardial lead assembly having a stent
US6251109B1 (en) * 1997-06-27 2001-06-26 Daig Corporation Process and device for the treatment of atrial arrhythmia
US6024740A (en) * 1997-07-08 2000-02-15 The Regents Of The University Of California Circumferential ablation device assembly
US6514249B1 (en) * 1997-07-08 2003-02-04 Atrionix, Inc. Positioning system and method for orienting an ablation element within a pulmonary vein ostium
US5991668A (en) * 1997-09-25 1999-11-23 Medtronic, Inc. Medical electrical lead
US6231516B1 (en) * 1997-10-14 2001-05-15 Vacusense, Inc. Endoluminal implant with therapeutic and diagnostic capability
US5967986A (en) * 1997-11-25 1999-10-19 Vascusense, Inc. Endoluminal implant with fluid flow sensing capability
US6237398B1 (en) * 1997-12-30 2001-05-29 Remon Medical Technologies, Ltd. System and method for monitoring pressure, flow and constriction parameters of plumbing and blood vessels
US6309370B1 (en) * 1998-02-05 2001-10-30 Biosense, Inc. Intracardiac drug delivery
US6254573B1 (en) * 1998-02-05 2001-07-03 Biosense, Inc. Intracardiac drug delivery device utilizing spring-loaded mechanism
US5980566A (en) * 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US20010000802A1 (en) * 1998-04-30 2001-05-03 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6141588A (en) * 1998-07-24 2000-10-31 Intermedics Inc. Cardiac simulation system having multiple stimulators for anti-arrhythmia therapy
US6501983B1 (en) * 1998-08-07 2002-12-31 Infinite Biomedical Technologies, Llc Implantable myocardial ischemia detection, indication and action technology
US5980563A (en) * 1998-08-31 1999-11-09 Tu; Lily Chen Ablation apparatus and methods for treating atherosclerosis
US6168801B1 (en) * 1998-09-09 2001-01-02 Cardiac Pacemakers, Inc. Controlled release drug delivery
US6154675A (en) * 1998-10-27 2000-11-28 Medtronic, Inc. Resetting ERI/POR/PIR/indicators in implantable medical devices
US6016448A (en) * 1998-10-27 2000-01-18 Medtronic, Inc. Multilevel ERI for implantable medical devices
US6016447A (en) * 1998-10-27 2000-01-18 Medtronic, Inc. Pacemaker implant recognition
US6361780B1 (en) * 1998-11-12 2002-03-26 Cardiac Pacemakers, Inc. Microporous drug delivery system
US6645145B1 (en) * 1998-11-19 2003-11-11 Siemens Medical Solutions Usa, Inc. Diagnostic medical ultrasound systems and transducers utilizing micro-mechanical components
US6115636A (en) * 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6519245B1 (en) * 1999-01-11 2003-02-11 Trimble Navigation Limited Communication system having dedicated time slots for selection signals
US6358202B1 (en) * 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US6424847B1 (en) * 1999-02-25 2002-07-23 Medtronic Minimed, Inc. Glucose monitor calibration methods
US6298272B1 (en) * 1999-03-29 2001-10-02 Cardiac Pacemakers, Inc. High impedance electrode tip with internal drug delivery capability
US6200265B1 (en) * 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
US6317615B1 (en) * 1999-04-19 2001-11-13 Cardiac Pacemakers, Inc. Method and system for reducing arterial restenosis in the presence of an intravascular stent
US6179789B1 (en) * 1999-05-03 2001-01-30 Lily Chen Tu Enhanced radioactive stent for reduction of restenosis
US6716242B1 (en) * 1999-10-13 2004-04-06 Peter A. Altman Pulmonary vein stent and method for use
US6361522B1 (en) * 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US6277078B1 (en) * 1999-11-19 2001-08-21 Remon Medical Technologies, Ltd. System and method for monitoring a parameter associated with the performance of a heart
US6542781B1 (en) * 1999-11-22 2003-04-01 Scimed Life Systems, Inc. Loop structures for supporting diagnostic and therapeutic elements in contact with body tissue
US20020026228A1 (en) * 1999-11-30 2002-02-28 Patrick Schauerte Electrode for intravascular stimulation, cardioversion and/or defibrillation
US6632223B1 (en) * 2000-03-30 2003-10-14 The General Hospital Corporation Pulmonary vein ablation stent and method
US6442413B1 (en) * 2000-05-15 2002-08-27 James H. Silver Implantable sensor
US6459917B1 (en) * 2000-05-22 2002-10-01 Ashok Gowda Apparatus for access to interstitial fluid, blood, or blood plasma components
US6453195B1 (en) * 2001-03-19 2002-09-17 Medtronic, Inc. Closed loop drug delivery system and remote management thereof
US20030069606A1 (en) * 2001-06-15 2003-04-10 Girouard Steven D. Pulmonary vein stent for treating atrial fibrillation
US20030004403A1 (en) * 2001-06-29 2003-01-02 Darrel Drinan Gateway platform for biological monitoring and delivery of therapeutic compounds
US20030158584A1 (en) * 2002-02-19 2003-08-21 Cates Adam W Chronically-implanted device for sensing and therapy

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040153139A1 (en) * 1999-10-13 2004-08-05 Biocardia, Inc. Pulmonary vein stent and method for use
US20040158313A1 (en) * 1999-10-13 2004-08-12 Biocardia, Inc. Pulmonary vein stent and method for use
US20030069606A1 (en) * 2001-06-15 2003-04-10 Girouard Steven D. Pulmonary vein stent for treating atrial fibrillation
US20040167598A1 (en) * 2002-11-08 2004-08-26 Margolis James R. Device and method for electrical isolation of the pulmonary veins
US7192438B2 (en) 2002-11-08 2007-03-20 Margolis James R Device and method for electrical isolation of the pulmonary veins
US20040106952A1 (en) * 2002-12-03 2004-06-03 Lafontaine Daniel M. Treating arrhythmias by altering properties of tissue
US20100222786A1 (en) * 2003-02-21 2010-09-02 Kassab Ghassan S Devices, systems, and methods for removing targeted lesions from vessels
US9603545B2 (en) * 2003-02-21 2017-03-28 3Dt Holdings, Llc Devices, systems, and methods for removing targeted lesions from vessels
US20090171445A1 (en) * 2003-03-03 2009-07-02 William Swanson Electrical Conduction Block Implant Device
US8409268B2 (en) 2003-03-03 2013-04-02 Syntach Ag Electrical conduction block implant device
US20040220655A1 (en) * 2003-03-03 2004-11-04 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
EP1605866A4 (en) * 2003-03-03 2007-03-07 Sinus Rhythm Technologies Inc Electrical conduction block implant device
EP1605866A2 (en) * 2003-03-03 2005-12-21 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
US8840658B2 (en) 2003-03-03 2014-09-23 Syntach Ag Electrical conduction block implant device
US20040220560A1 (en) * 2003-04-29 2004-11-04 Briscoe Roderick E. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US20090138008A1 (en) * 2003-04-29 2009-05-28 Medtronic, Inc. Endocardial Dispersive Electrode for Use with a Monopolar RF Ablation Pen
US7871409B2 (en) 2003-04-29 2011-01-18 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US9295484B2 (en) 2003-11-17 2016-03-29 Syntach Ag Device, a kit and a method for treatment of disorders in the heart rhythm regulation system
US8257376B2 (en) 2003-11-17 2012-09-04 Syntach Ag Device, a kit and a method for treatment of disorders in the heart rhythm regulation system
US9398967B2 (en) 2004-03-02 2016-07-26 Syntach Ag Electrical conduction block implant device
US20060178725A1 (en) * 2004-03-02 2006-08-10 Sinus Rhythm Technologies, Inc. Electrical conduction block implant device
US7645285B2 (en) 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US20060020271A1 (en) * 2004-06-18 2006-01-26 Stewart Mark T Methods and devices for occlusion of an atrial appendage
US9656063B2 (en) 2004-06-18 2017-05-23 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US20060116666A1 (en) * 2004-10-08 2006-06-01 Sinus Rhythm Technologies, Inc. Two-stage scar generation for treating atrial fibrillation
US20090171444A1 (en) * 2004-10-08 2009-07-02 Richard Cornelius Two-Stage Scar Generation for Treating Atrial Fibrillation
US20060089709A1 (en) * 2004-10-21 2006-04-27 Helmus Michael N Medical implant with average surface charge density
US20070239252A1 (en) * 2006-04-10 2007-10-11 Medtronic Vascular, Inc. A Mechanism to Ensure Placement of Ostial Renal Stents
US9408659B2 (en) 2007-04-02 2016-08-09 Atricure, Inc. Surgical instrument with separate tool head and method of use
US20100179570A1 (en) * 2009-01-13 2010-07-15 Salvatore Privitera Apparatus and methods for deploying a clip to occlude an anatomical structure
US9393023B2 (en) 2009-01-13 2016-07-19 Atricure, Inc. Apparatus and methods for deploying a clip to occlude an anatomical structure
US9017349B2 (en) 2010-10-27 2015-04-28 Atricure, Inc. Appendage clamp deployment assist device
US9066741B2 (en) 2010-11-01 2015-06-30 Atricure, Inc. Robotic toolkit
US8636754B2 (en) 2010-11-11 2014-01-28 Atricure, Inc. Clip applicator
US20140031785A1 (en) * 2011-04-01 2014-01-30 Flux Medical N.V. System, device and method for ablation of a vessel's wall from the inside
US9572618B2 (en) * 2011-04-01 2017-02-21 Medical Development Technologies S.A System, device and method for ablation of a vessel's wall from the inside
US9526572B2 (en) 2011-04-26 2016-12-27 Aperiam Medical, Inc. Method and device for treatment of hypertension and other maladies
US9265486B2 (en) 2011-08-15 2016-02-23 Atricure, Inc. Surgical device
US20130090651A1 (en) * 2011-10-11 2013-04-11 Boston Scientific Scimed, Inc. Off-wall electrode device and methods for nerve modulation
US9282973B2 (en) 2012-01-20 2016-03-15 Atricure, Inc. Clip deployment tool and associated methods
CN103385754A (en) * 2012-05-09 2013-11-13 韦伯斯特生物官能(以色列)有限公司 Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
US9439722B2 (en) 2012-05-09 2016-09-13 Biosense Webster (Israel) Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
EP2662048A3 (en) * 2012-05-09 2013-12-25 Biosense Webster (Israel), Ltd. Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension
JP2015521065A (en) * 2012-05-18 2015-07-27 テウン メディカル カンパニー リミテッド Ablation combined stent performing device
US20150133927A1 (en) * 2012-05-18 2015-05-14 Taewoong Medical Co. Ltd Combined Cauterization and Stent Operation Device
CN104519837A (en) * 2012-05-18 2015-04-15 太雄医疗器株式会社 Combined cauterization and stent operation device
EP2851024A4 (en) * 2012-05-18 2016-03-02 Taewoong Medical Co Ltd Combined cauterization and stent operation device
US9770353B2 (en) * 2012-05-18 2017-09-26 Taewoong Medical Co., Ltd. Combined cauterization and stent operation device
US9782213B2 (en) 2012-05-18 2017-10-10 Starmed Co., Ltd. Overlapping bipolar electrode for high-frequency heat treatment

Also Published As

Publication number Publication date Type
US7209783B2 (en) 2007-04-24 grant

Similar Documents

Publication Publication Date Title
Delacretaz et al. Mapping and radiofrequency catheter ablation of the three types of sustained monomorphic ventricular tachycardia in nonischemic heart disease
US6771996B2 (en) Ablation and high-resolution mapping catheter system for pulmonary vein foci elimination
US5462544A (en) Continuous heart tissue mapping and lasing catheter
US5871523A (en) Helically wound radio-frequency emitting electrodes for creating lesions in body tissue
US5882346A (en) Shapable catheter using exchangeable core and method of use
US5769846A (en) Ablation apparatus for cardiac chambers
US7572257B2 (en) Vacuum coagulation and dissection probes
US6241726B1 (en) Catheter system having a tip section with fixation means
US7591816B2 (en) Irrigated ablation catheter having a pressure sensor to detect tissue contact
US6001093A (en) Systems and methods for creating long, thin lesions in body tissue
US7048734B1 (en) Systems and methods for electronically altering the energy emitting characteristics of an electrode array to create different lesion patterns in body tissue
US6296630B1 (en) Device and method to slow or stop the heart temporarily
US7429261B2 (en) Atrial ablation catheter and method of use
Haı̈ssaguerre et al. Mapping-guided ablation of pulmonary veins to cure atrial fibrillation
Goy et al. Clinical efficacy of radiofrequency current in the treatment of patients with atrioventricular node reentrant tachycardia
US20010029366A1 (en) Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like
US7104990B2 (en) Loop structure including inflatable therapeutic device
US6231570B1 (en) Electrode catheter system for tissue ablation
US6106520A (en) Endocardial device for producing reversible damage to heart tissue
US20070156185A1 (en) Ablative treatment of the heart to improve patient outcomes following surgery
US20010044619A1 (en) Cardiac drug delivery system and method for use
US5718241A (en) Apparatus and method for treating cardiac arrhythmias with no discrete target
Huang et al. Short-and long-term effects of transcatheter ablation of the coronary sinus by radiofrequency energy.
US7255695B2 (en) Systems and methods for three-dimensional mapping of electrical activity
Boersma et al. Pulmonary vein isolation by duty-cycled bipolar and unipolar radiofrequency energy with a multielectrode ablation catheter

Legal Events

Date Code Title Description
AS Assignment

Owner name: CARDIAC PACEMAKERS, INC., MINNESOTA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:FELLOWS, CHRIS;BOWE, WADE A.;WOOD, DAVID S.;REEL/FRAME:013331/0819;SIGNING DATES FROM 20020722 TO 20020815

CC Certificate of correction
FPAY Fee payment

Year of fee payment: 4

REMI Maintenance fee reminder mailed
LAPS Lapse for failure to pay maintenance fees
FP Expired due to failure to pay maintenance fee

Effective date: 20150424