US20020151945A1 - Indwelling heat exchange catheter and method of using same - Google Patents

Indwelling heat exchange catheter and method of using same Download PDF

Info

Publication number
US20020151945A1
US20020151945A1 US10/127,209 US12720902A US2002151945A1 US 20020151945 A1 US20020151945 A1 US 20020151945A1 US 12720902 A US12720902 A US 12720902A US 2002151945 A1 US2002151945 A1 US 2002151945A1
Authority
US
United States
Prior art keywords
catheter
fluid
heat exchange
balloon
body
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/127,209
Inventor
Yves Gobin
Scott Evans
Mike Jones
Wayne Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Alsius Corp
Original Assignee
University of California
Alsius Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US09/063,984 priority Critical patent/US6126684A/en
Priority to US09/546,814 priority patent/US6416533B1/en
Application filed by University of California, Alsius Corp filed Critical University of California
Priority to US10/127,209 priority patent/US20020151945A1/en
Assigned to ALSIUS CORPORATION, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA reassignment ALSIUS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EVANS, SCOTT M., JONES, MIKE L., NODA, WAYNE A., GOBIN, YVES PIERRE
Publication of US20020151945A1 publication Critical patent/US20020151945A1/en
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/10Balloon catheters
    • A61M25/1011Multiple balloon catheters

Abstract

A catheter is adapt to exchange heat with a body fluid, such as blood, flowing in a body conduit, such as a blood vessel. The catheter includes a shaft with a heat exchange region disposed at its distal end. This region may include at least one balloon which is adapted to receive a remotely cooled heat exchange fluid preferably flowing in a direction counter to that of the body fluid. Embodiments including multiple balloons enhance the surface area of contact, and the mixing of both the heat exchange and the body fluid. The catheter car be positioned to produce hypothermia in a selective area of the body without cooling the entire body system. It is of particular advantage in brain surgeries where stroke, trauma or cryogenic tumors can best be addressed under hypothermic conditions.

Description

    BACKGROUND OF THE INVENTION
  • 1. Field of the Invention [0001]
  • This invention relates generally to apparatus and methods for producing heat exchange with body tissue, and more specifically to methods and apparatus for the hypothermic treatment of a body fluid in a body conduit. [0002]
  • 2. Discussion of the Prior Art [0003]
  • Many of the advantages of hypothermia are well known. By way of example, it has been found particularly desirable to lower the temperature of body tissue in order to reduce the metabolism of the body. In stroke and several other pathological conditions, hypothermia also reduces the permeability of the blood/brain barrier. It inhibits release of damaging neurotransmitters and also inhibits calcium-mediated effects. Hypothermia inhibits brain edema and lowers intracranial pressure. [0004]
  • Some of the disadvantages of systemic hypothermia include cardiac arrhythmia, pulmonary edema and coagulopathies. Systemic hypothermia also results in hypotension and various immunodeficiencies. [0005]
  • In the past, hypothermic treatment has been addressed systemically, meaning that the overall temperature of the entire body has been lowered to achieve the advantages noted above. This has been particularly desirable in surgical applications where the reduced metabolism has made it possible to more easily accommodate lengthy operative procedures. An example of this systemic approach includes catheters for transferring heat to or from blood flowing within a patient's vessel, as disclosed by Ginsburg in U.S. Pat. No. 5,486,208. A closed loop heat exchange catheter is also disclosed by Saab in U.S. Pat. No. 5,624,392. [0006]
  • The systemic approach is not always advantageous when the beneficial effects are desired locally at the focus of the operative procedure and only the disadvantages of hypothermia are felt throughout the remainder of the body. [0007]
  • As a result, more recent focus has been directed to producing hypothermia in localized areas of the body, leaving the remainder of the body to function at a normal body temperature. These localized applications of hypothermia have been external, relying for example on cooling helmets or cooling neck collars to produce localized hypothermia for the brain. [0008]
  • SUMMARY OF THE INVENTION
  • A heat exchange catheter and method of operation are included in the present invention. The method is adapted to produce hypothermia or hyperthermia in a selected portion of the body without substantially varying the temperature of the remaining portions of the body. The selected-body portion will typically be associated with a body conduit which conveys a body fluid to the selected body portion. Of particular interest are the organs of the body which are commonly nourished and maintained by a flow of blood in the arterial system. For example, a flow of blood is introduced to the brain through the carotid artery. Of course the temperature of this blood is usually at the normal body temperature. [0009]
  • By positioning a heat exchange catheter in the body conduit, heat can be added to or removed from the body fluid to heat or cool the selected body portion. For example, the heat exchange catheter can be disposed in the carotid artery where the arterial blood flowing to the brain can be cooled. The flow of cooled blood to the brain reduces the temperature of the brain thereby resulting in cerebral hypothermia. Importantly, this temperature reduction occurs primarily and selectively in the brain; the remaining portions of the body maintain a generally normal body temperature. In accordance with this method, the selected body portion, such as the brain, can be cooled thereby providing the advantages associated with hypothermia for this body portion. The remainder of the body, such as the portions other than the brain, do not experience the reduction in temperature and therefore are not susceptible to the disadvantages of hypothermia. Furthermore, the invention is intended to remotely alter temperature in a region other than the point of introduction into the body, this is different than devices intended for systemic temperature control. [0010]
  • Several factors are of interest in effecting heat transfer in a heat exchanger. These factors include, for example, the convection heat transfer coefficient of the two fluids involved in the heat exchange, as well as the thermal conductivity and thickness of the barrier between the two fluids. Other factors include the relative temperature differential between the fluids, as well as the contact area and residence time of heat transfer. The Reynolds number for each fluid stream affects boundary layers, turbulence and laminar flow. [0011]
  • With concern for these factors, the heat exchange catheter of the present invention includes a shaft having an axis, a fluid inlet lumen and a fluid outlet lumen each extending generally between a proximal end and a distal end of the shaft. A hub disposed at the proximal end provides access to the fluid lumens. At least one balloon is provided in a heat exchange region at the distal end of the shaft, the balloon wall providing the barrier between the two fluids. With the catheter positioned in contact with the body fluid within the conduit, heat transfer occurs across the balloon wall. The relative temperature differential is facilitated with countercurrent flow between the two fluids. [0012]
  • In one aspect of the invention, a first balloon is disposed at the distal end of the shaft and defines with the shaft an inflatable first cavity. Portions of the shaft define a first inlet hole extending in fluid communication between the first lumen and the first cavity. Portions of the shaft define a first outlet hole extending in fluid communication between the first cavity and the fluid outlet lumen. A second balloon disposed relative to the first balloon defines with the shaft an inflatable second cavity with portions of the shaft defining a second inlet hole between the fluid inlet lumen and the second cavity. Portions of the shaft also define a second outlet hole in fluid communication with the second cavity and the fluid outlet lumen. Typically, the first balloon will be disposed distally of the second balloon and the first inlet hole will be larger than the second inlet hole. An elastomeric material covering a valley or volume between the first balloon and the second balloon may be provided to promote mixing necessary for efficient heat exchange yet minimize turbulence and shear which can be damaging to blood. [0013]
  • In an additional aspect of the invention, a method for exchanging heat with a body fluid in a body conduit includes the step of introducing into the body conduit a catheter having an inlet lumen and an outlet lumen. The catheter is provided with a first cavity and a second cavity each in heat transfer relationship with the body fluid ,in the body conduit. A heat exchange fluid is introduced into the inlet lumen and through an inlet hole into each of the first cavity and the second cavity. An exchange of heat then occurs between the heat exchange fluid in the first and second cavities and the body fluid in the body conduit. Ultimately, the heat exchange fluid is removed through an outlet hole and the outlet lumen associated with each of the first cavity and the second cavity. Creating non laminar flow in one or both of the heat exchange fluid and the body fluid will improve heat transfer efficiency. Heat transfer can also be effected by various structures which either enhance or inhibit turbulence in the fluids. [0014]
  • These and other features and advantages of the invention will be better understood with a description of the preferred embodiments of the invention and reference to the associated drawings. [0015]
  • DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is side elevation view of a patient lying in a prone position with a heat exchange catheter of the present invention appropriately inserted to facilitate hypothermic treatment of the patient's brain; [0016]
  • FIG. 2 is an enlarged side elevation view showing the vasculature associated with the patient's head and brain; [0017]
  • FIG. 3 is a perspective view partially in section of a heat exchange region of the catheter; [0018]
  • FIG. 4 is an enlarged axial cross section view of a plurality of balloons disposed in the heat exchange region of the catheter; [0019]
  • FIG. 5 is a radial cross section view of the catheter taken along lines [0020] 5-5 of FIG. 4;
  • FIG. 6 is a radial cross section view similar to FIG. 5 of a further embodiment of the catheter; [0021]
  • FIG. 7 is a perspective view of a further embodiment of the catheter wherein multiple balloons are provided with a longitudinal configuration; [0022]
  • FIG. 8 is a radial cross section view taken along lines [0023] 8-8 of FIG. 7;
  • FIG. 9 is an axial cross section view taken along lines [0024] 9-9 of FIG. 7;
  • FIG. 10 is a perspective view of the catheter illustrated in FIG. 3 further illustrating structures which can facilitate mixing and heat exchange; [0025]
  • FIG. 10A is a perspective view of an embodiment of the catheter having a distal end with a pigtail configuration; [0026]
  • FIG. 10B is a perspective view of the catheter illustrated in FIG. 10A with the distal end straightened by a stylet [0027] 174 to facilitate insertion of the catheter;
  • FIG. 11 is a schematic view of an embodiment including a heat pipe; [0028]
  • FIG. 12 is a schematic view, partially in section, of a heat pipe adapted for use in the embodiment of FIG. 11; [0029]
  • FIG. 13 is a top plan view of carotid artery branch illustrating one method of operation associated with the catheter; [0030]
  • FIG. 14 is a top plan view similar to FIG. 13 and showing a further method of operation with the catheter; [0031]
  • FIG. 15 is a top plan view of the carotid branch similar to FIG. 13 and showing a further method of operating a heat exchange catheter; [0032]
  • FIG. 16 is a radial cross section of the catheter taken along lines [0033] 16-16 of FIG. 15;
  • FIG. 17 is an axial cross section view of a further embodiment of the invention including hollow fibers in the heat exchange region; [0034]
  • FIG. 18 is a side elevation view similar to FIG. 17 and illustrating the hollow fibers in a compacted configuration; and and configured to permit the hollow fibers to float and undulate within a blood stream.[0035]
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS AND BEST MODE OF THE INVENTION
  • A heat exchange catheter is illustrated in FIG. 1 and designated generally by the reference numeral [0036] 10. The catheter 10 is operatively disposed with respect to a body 12 of a patient having a groin 14, a head 16, and a brain 18. More specifically, the catheter 10 can be inserted percutaneously through a puncture or surgical cut down at the groin 14, and into the femoral artery 21. Following this initial introduction, the catheter 10 can be moved through the femoral artery 21 and the aortic arch 23, into the common carotid artery 25 best illustrated in FIG. 2. This common carotid artery 25 divides at a carotid branch 27 into an external carotid artery 30, which primarily supplies blood 31 to the face of the patient, and an internal carotid artery 32, which primarily supplies blood to the brain 18 of the patient.
  • In the concept of this invention, the brain [0037] 18 is merely representative of a portion of the body 12 of the patient, and the arteries 21, 25, 30 and 32 are merely representative of conduits which supply a body fluid, such as blood, to a selected portion of the body 12, such as the brain 18. By cooling the body fluid, such as blood 31, in the body conduit, such as the artery 32, the specific body portion, such as the brain 18, can be selectively cooled without significantly affecting the temperature of the remaining portions of the body 12.
  • Selective hypothermic treatment of the brain [0038] 18 is initially of particular interest as it captures the advantages of hypothermia during operative procedures associated with the brain 18 without also capturing the disadvantages of hypothermia with respect to other areas of the body 12. Thus, a surgeon operating to treat an aneurysm in the brain 18, for example, can initially cool the brain 18 in order to facilitate that procedure. This selective hypothermia will be particularly appreciated in those surgical procedures which are primarily directed to the brain 18. Procedures such as stroke, trauma, and other brain related injures will also benefit up to and during from this selective hypothermia treatment.
  • A preferred embodiment of the catheter [0039] 10 of the present invention is illustrated in FIGS. 3 and 4. From this perspective view, it can be seen that the catheter 10 includes a shaft 40 having an axis 41 which extends between a proximal end 43 and a distal end 45. When operatively disposed, a heat exchange region 47 at the distal end 45 is operatively disposed Within the body 12, and a hub 50 at the proximal end 43 is disposed outside of the body 12. Within the shaft 40, a plurality of lumens 52 and 54 extend in fluid communication with the hub 50 and the heat exchange region 47.
  • A preferred embodiment of the heat exchange region [0040] 47 is illustrated in greater detail in FIG. 4 where three balloons 56, 58 and 61 are individually, separately and axially disposed along the shaft 40. It will be appreciated that although the illustrated embodiment includes three balloons, a single balloon or double balloon embodiment may offer further advantages in a particular procedure, All of the balloons 56, 58 and 61 are illustrated to have a significantly larger diameter than the shaft 40. This may not be the case in other embodiments. More specifically, it may be desirable to maximize the dimension of the shaft 40 in order to facilitate flow of the heat exchange fluid. This will also minimize the volume of fluid in the balloon and promote a more rapid heat exchange. In one such embodiment, the diameter of the shaft 40 is in a range between 50 and 90 percent of the diameter of the balloons 56, 58 and 61.
  • Each of the balloons [0041] 56, 58 and 61 can be formed from a piece of sheet material 62, 64 and 66 which is bound or otherwise fixed to the shaft 40 to form a cavity 63, 65 and 67, respectively. An inlet hole 70 provides fluid communication between the lumen 54 and the cavity 63 of the balloon 56. Similar inlet holes 72 and 74 are provided for the balloons 58 and 61. In a like manner, an outlet hole 76 can be formed in the wall of the shaft 40 to provide fluid communication between the lumen 52 and the cavity 63 of the balloon 56. Similar outlet holes 78 and 81 are provided for the balloons 58 and 61, respectively. With this structure, it can be seen that the lumen 54 functions primarily as an inlet lumen for a heat exchange fluid which is illustrated generally as a series of arrows designated by the reference numeral 85.
  • Initially, the heat exchange fluid [0042] 85 is introduced through the hub 50 (FIG. 3) and into the inlet lumen 54. From the lumen 54, the heat exchange fluid 85 passes through the inlet holes 70, 72, 74 and into the respective balloon cavity 63, 65 and 67. The heat exchange fluid 85 then passes into the outlet hole 76, 78, 81 and into the outlet lumen 52 and the hub 50 to regions exterior of the catheter 10.
  • After the heat exchange fluid [0043] 85 is remotely cooled, it is circulated through the balloon cavities 63, 65 and 67 to provide a cold temperature fluid on the inner surface of the sheet materials 62, 64 and 66 which form the walls of the balloons 56, 58 and 61, respectively. With a body fluid, such as blood 31, flowing exteriorly of the balloons 56, 68 and 61, heat transfer occurs across the sheet materials 62, 64 and 66, respectively.
  • It can be appreciated that this circulation of the heat exchange fluid [0044] 85 can be formed Birth any structure of the shaft 40 which provides two lumens, such as the lumens 52 and 54, each of which can have access to the balloon cavities, such as the cavities 63, 65 and 67. In one embodiment of the shaft 40 illustrated in FIG. 5, a septum 90 is provided which separates the cylindrical shaft 40 into two equally sized lumens 52 and 54. In the embodiment of FIG. 6, the cylindrical shaft 40 is provided with a cylindrical septum 92 which provides the lumen 54 with a circular cross section and the lumen 52 with a moon-shaped cross section. In such an embodiment, the lumen 54 must be defined off-axis from the shaft 40 in order to have access to the balloon cavities, such as the cavity 63.
  • One of the advantages of a multiple balloon embodiment of the catheter [0045] 10 is that the flow and temperature of the heat exchange fluid 85 can be more easily controlled along the entire length of the heat exchange region 47. Realizing that the heat exchange fluid 85 will be coolest prior to entering into a heat exchange with the blood 31, and warmest after that heat exchange, one can advantageously control not only the velocity and volume of flow, but also the direction of flow within each discrete balloons 56, 58 and 61. Another advantage of a multiple balloon design is the ability of the catheter to bend and flex when placed in a curved vasculature. Single balloon designs would be rigid, stiff and inflexible by comparison.
  • In order to facilitate the maximum heat exchange between the fluid [0046] 85 and the blood, it is desirable to provide a balanced flow of the heat exchange fluid 85 along the entire length of the heat exchange region 47. In the embodiment illustrated in FIG. 4, efficient heat transfer is facilitated by counter current flow where the heat exchange fluid 85 is directed to flow counter to the flow of the blood 31. To that end, the inlet holes 70, 72 and 74 are positioned distally of the outlet holes 76, 78 and 81, respectively. As the blood 31 flows distally along the outer surface of the catheter 10, this relative position of the inlet holes and outlet holes causes the heat exchange fluid to flow in the opposite direction, proximally in each of the balloons 56, 58 and 61.
  • The amount of flow within each of the balloons [0047] 56, 58 and 61 can also be controlled by the size of the inlet holes 70, 72, 74 and outlet holes 76, 78 and 81. In a preferred embodiment, this flow control is provided solely by the inlet holes 70, 72 and 74; the outlet holes 76, 78 and 81 are sized larger than their respective inlet holes so that they offer little resistance to flow. In this embodiment, the inlet holes 70, 72 and 74 are sized to be progressively smaller from the distal end 45 to the proximal end 43. Thus the hole 70 is larger than the hole 72 which is larger than the hole 74. As a result, the resistance to the flow of heat exchange fluid 85 in the most distal balloon 56 is less than that in the most proximal balloon 61. This ensures that the coolest heat exchange fluid 85 is shared equally among all of the balloons 56, 58 and 61 regardless of their position along the shaft 40. In an embodiment wherein the flow is controlled by the outlet holes 76, 78 and 81, these holes can also be provided with a relatively reduced size from the distal end 45 to the proximal end 43. With any of these structures, a more balanced flow of the heat exchange fluid can be achieved in order to facilitate the highest degree of heat exchange along the entire heat exchange region 47. Alternatively, the flow of heat exchange fluid can also be balanced by providing the holes 76, 78 and 81 with non-circular configurations. For example, these holes may be formed as longitudential slits extending axially of the catheter.
  • A further embodiment of the invention is illustrated in FIG. 7 wherein a single sheet of material [0048] 101 is used to form separate and distinct individual balloons, two of which are designated by the reference numerals 103 and 105. As opposed to the radial balloons 56, 58 and 61 of the previous embodiment, the balloons 103 and 105 extend axially along the surface of the shaft 40. For example, the balloons 103 and 105 form individual balloon cavities 107 and 110, respectively, which extend from a distal end 112 to a proximal end 114.
  • This embodiment of the catheter containing the axial balloons [0049] 103 and 105 may include a shaft 40 with a slightly different configuration. As best illustrated in FIG. 9, the shaft 40 may include an outer tube 121 having an outer surface to which the sheet material 101 is attached and within which is disposed a distal sealing plug 123. An inner tube 125, which can be disposed coaxially with the outer tube 121, has an inner lumen 127 and defines with the outer tube 121 an outer lumen 130. A pair of inlet holes 132 and 134 provide flow fluid communication between the inner lumen 127 and the balloon cavities 107 and 110, respectively. Similarly, a pair of outlet holes 136 and 138 provide fluid communication between the balloon cavities 107 and 110 and the outer lumen 130, respectively. An inner plug 141 disposed between the inner tube 125 and outer tube 121 to seal the outer lumen 130 between the inlet holes 132, 134 and outlet holes 136, 138. For the reasons previously noted, a preferred embodiment has inlet holes 132, 134 which are disposed distally of and sized smaller than the outlet holes 136, 138, respectively. This orientation will provide countercurrent flow in a catheter 10 which is inserted downstream into an artery such as the carotid artery 25.
  • Embodiments which are intended to maximize heat transfer will take advantage of the fact that heat exchange is enhanced when either, or both, the body fluid or the heat exchange fluid is provided with well mixed flow. Mixing can be enhanced by providing irregular surfaces next to which either of these fluids flow. For example, with reference to FIG. 4, it will be noted that a spring [0050] 150 can be disposed around the shaft 40 inside each of the balloons, such as the balloon 61. In this embodiment, the spring 150 upsets the laminar flow of the heat exchange fluid 85 thereby producing the desired mixing of this fluid. Other structures can be positioned within the cavities formed by the balloons 56, 58 and 61.
  • Mixing can also be enhanced within the body fluid which flows along the outer surface of the catheter [0051] 10. In this case, the multiple radial balloon embodiment illustrated in FIG. 4 is of advantage as each of the balloons 56, 58 and 61 represents a peak and defines with the adjacent balloon a valley along which the blood 31 flows. This series of peaks and valleys also upsets the laminar flow of the body fluid. Mixing of the body fluid can also be enhanced by providing other structures along the outer surface of the sheet material 62, 64 and 66 which form the balloons as well as any exposed areas of the shaft 40 in the heat exchange region 47. By way of example, a multiplicity of granules 145 can be adhered to the outer surface of the radial balloons 56, 58 and 61 or the axial balloons 103 and 105 as illustrated in FIG. 9. Ridges can also be provided along these surfaces.
  • With some body fluids, it may be desirable to inhibit turbulent flow and facilitate laminar flow. This may be true for example in the case of blood where undesirable hemolysis may occur in response to increased turbulence. Such an embodiment might be particularly desirable for use with radial balloons where an outer balloon [0052] 152 would promote laminar flow by reducing the height differential between the peaks and valleys defined by the balloons 56, 58 and 61. This outer balloon 152 is best illustrated in FIG. 10. To further promote laminar flow, the outer surface of any structure in the heat exchange region 47 can be provided with a coating 154, such as a hydrophilic or a hydrophobic coating to modify the boundary layer. Thus the outer surface of the shaft 40 as well as the outer surface of any of the balloons 56, 58, 61, 103, 105 and 152 can be provided with the coating 154. The coating 154 may also include other ingredients providing the catheter 10 with additional advantageous properties. For example, the coating 154 may include an antithrombogenic ingredient such as heparin or aspirin. Such a coating 154 would not only inhibit platelet deposition but also the formation of blood clots.
  • As previously noted, the characteristics of the heat exchange fluid [0053] 85 may also be of importance in a particular heat exchange environment. Although the heat exchange fluid 85 may include various liquids, it is believed that gases may provide the greatest temperature differential with the body fluid. Particularly if this fluid includes blood, gases that are inert or otherwise compatible with the vascular system will be appreciated. Although several inert gases might fulfill these requirements, carbon dioxide is used for the heat exchange fluid 85 in a preferred embodiment of the invention.
  • A further embodiment of the catheter [0054] 10 is contemplated for maximizing the surface area available for heat exchange. As illustrated in FIGS. 10A and 10B, the catheter 10 can be formed with a distal end 45 of the shaft 40 disposed in the natural configuration of a spiral or pigtail 172. The relatively large diameter of the pigtail 172 facilitates heat exchange, but tends to deter from a low profile desire for insertion. Under these circumstances, it may be advantageous to insert the catheter 10 over a stylet or guidewire 174 in order to straighten the pigtail 172 as illustrated in FIG. 10B.
  • Hyperthermia and hypothermia for selective regions of the body can also be achieved by placing in the body conduit, such as the carotid artery [0055] 25, a heat pipe 161 best illustrated in the schematic view of FIG. 11. In this embodiment, the heat pipe 161 includes a distal end 163 and proximal end 165. The distal end 163 is adapted to be placed within the body conduit, such as the carotid artery 25. The proximal end 165 of the heat pipe 161 is adapted to be connected to an external heat sink or cooler, such as a thermoelectric cooler 167 or water jacket 168. A wick structure 170 is provided in the heat pipe 161 to facilitate a flow of heat exchange fluid from the cooler 167 to the distal end 163.
  • In a process involving the heat pipe [0056] 161, illustrated in FIG. 12, the heat exchange fluid is moved from the proximal end 165 of the heat pipe 161 either by gravity or by capillary action of the wick structure 170 to the distal end 163. At the distal end 163 of the heat pipe 161, heat is transferred from the body fluid, such as blood, to the heat exchange fluid in its liquid state. This heat exchange liquid absorbs a heat of vaporization as it passes into a vapor state in the heat pipe 161. The heat exchange fluid in its vapor state creates a pressure gradient between the ends 163 and 165 of the heat pipe 161. This pressure gradient causes the vapor to flow to the cooler 165 where it is condensed giving up its latent heat of vaporization. The heat exchange fluid in its liquid state then passes back through the heat pipe 161 through the wick structure 170 or by gravity. The passive heat exchange system provided by the heat pipe 161 is vacuum-tight and can be operated with a minimum amount of the heat exchange fluid.
  • Although the heat exchange catheter [0057] 10 will be advantageous in the hyperthermic or hypothermic treatment of any portion of the body 12, it is believed that it still be particularly appreciated in those procedures which can benefit from the hypothermic treatment of the brain 18, such as the treatment of ischemic stroke and/or head trauma. As previously noted in comments directed to FIG. 1, the catheter 10 can be inserted into the femoral artery in the groin 14 and directed through the aortic arch 23 into the common carotid artery 25. As illustrated in FIG. 13, the catheter 10 can then be moved into the region of the arterial branch 27 where it will encounter the external carotid artery 30 and the internal carotid artery 32. Since the external carotid artery 30 is directed primarily to the facial regions, it does not supply a significant amount of blood to the brain 18. In contrast, the internal carotid artery 32 is almost solely responsible for feeding the capillary bed of the brain 18. Based on these considerations, hypothermic treatment of the brain 18 is best addressed by cooling the blood in the internal carotid artery 32 without wasting any of the cooling properties on the external carotid artery 30. In a method associated with one embodiment of the invention, the most distal of the balloons, such as the balloon 56 in FIG. 13 is preferably positioned within the internal carotid artery 32. The more proximal balloons 58 and 61 can be disposed along the common carotid artery 25. This embodiment of the catheter 10 and its associated method will achieve a higher degree of heat transfer within the internal artery 32 than the external artery 30.
  • In another embodiment of the catheter [0058] 10 best illustrated in FIG. 14, an occlusion balloon 175 is provided distally of the heat exchange region 47. In this embodiment, the occlusion balloon 175 will preferably be inflatable through a separate lumen in the shaft 40. As the catheter 10, approaches the carotid branch 27, the occlusion balloon 81 is directed into the external carotid artery 30 and inflated in order to at least partially occlude that artery, The remaining proximal balloons 56, 58 and 61 in the neat exchange region 47 are left within the common carotid artery 25 to promote heat exchange with the blood flowing to the branch 27. With the external artery 30 at least partially occluded, heat transfer occurs primarily with the blood flowing into the internal carotid artery 32.
  • A further embodiment of the invention is illustrated in FIG. 15 operatively disposed in the common carotid artery [0059] 25 and internal carotid artery 32. In this case, the catheter 10 includes a balloon 181 which is attached to the distal end of the shaft 40. In this case, the balloon 181 is provided with a spiral configuration. More specifically, the balloon 181 may be formed from several individual balloons, as with the embodiment of FIG. 7, for as individual flutes 183 on the single balloon 181. In either case, the separate balloons (such as the balloons 103, 105 of FIG. 7) or the flutes 183 are oriented in a spiral configuration around the axis 41 of the catheter 10. The shaft 40 can be provided with any of the configurations previously discussed such as the accentric configuration or FIG. 6.
  • By providing the balloon [0060] 181 with a spiral configuration, heat exchange is enhanced by at least two of the factors previously discussed. Notably, the surface area of contact is increased between the blood 31 flowing externally of the balloon 181 and the heat exchange fluid flowing internally of the balloon 181. The spiral configuration also enhances the mixing properties of both the blood 31 and the heat exchange fluid 85.
  • As noted, the heat exchange fluid [0061] 85 may be cooled to a sub-zero temperature such as −18° C. In order to thermally protect the internal lining of the artery 32 from direct contact with the sub-zero coolant, it may be desirable to provide the tips of the flutes 183 with a thicker wall 185, as shown in FIG. 16. This thicker wall 185 might be advantageous in any of the balloon configurations previously discussed, but would appear to be most advantageous in the embodiments of FIGS. 7 and 15 where the contact with the artery 32 tends to be more localized by the longitutudal balloons 103, 105 (FIG. 7) on the spiral flutes 183 (FIG. 15).
  • Still a further embodiment of the invention is illustrated in FIG. 17. In this embodiment, the shaft [0062] 40 includes an inner tube 190 disposed within an outer tube 192. These tubes 190, 192 may be concentric and longitutingly movable relative to each other. The tubes 190, 192 terminate respectively in manifolds 194, 196. Between these manifolds 194, 196, a multiplicity of hollow fibers 198 can be disposed at the distal end 45 to define the heat exchange region 47 or the catheter 10. The hollow fibers 198 each include an internal lumen which provides fluid communication between the manifolds 194 and 196. In operation, the heat exchange fluid 85 flows distally along the inner tube 190 into the distal manifold 194. From this manifold 194, the heat exchange fluid 85 flows into the internal lumens of the hollow fibers 198 proximally to the proximal manifold 196. The warmer heat exchange fluid 85 flows proximally from the manifold 196 between the inner tube 190 and outer tube 192.
  • The hollow fibers [0063] 198 offer several advantages to this embodiment of the catheter 10. Notably, they provide a very high surface area between the blood 31 and the heat exchange fluid 85. This greatly enhances the heat exchange characteristics of this embodiment. Countercurrent flow can also be maintained further facilitating the heat exchange capabilities of this catheter.
  • The hollow fibers [0064] 198 can be spiraled as illustrated in FIG. 18 by twisting the inner tube 190 with respect to the outer tube 192. This characteristic can be used to provide a shorter and lower profile heat exchange region 47 in order to facilitate introduction of the catheter 10. A lower profile may also be obtained by separating the manifolds 194 and 197 a distance substantially equal to the length of the fibers 198. This will tend to hold the fibers in a straight, parallel relationship and thereby facilitate introduction of the catheter 10. The spiraled configuration of the hollow fibers 198 can be maintained during heat exchange in order to further increase the heat exchange area per unit length of the catheter 10. Alternatively, the fibers 198 can be positioned to loosely float and undulate between the manifolds 194 and 196 as illustrated in FIG. 19. This characteristic of the fibers 198 will not only provide the increased heat exchange area desired, but also promote mixing within the blood 31.
  • Generally speaking with respect to any of the balloon embodiments previously discussed, it will be appreciated that the advantages of this invention can be derived with respect to a single balloon. On the other hand, there seem to be several advantages associated with multiple balloon embodiments. Notably, a more even and balanced transfer of heat exchange can be achieved with multiple balloons. In addition, there appears to be better mixing with respect to both the blood [0065] 31 as well as the heat exchange fluid 85. Multiple balloons also provide an increased surface area relative to single balloon embodiments. Furthermore, the overall flexibility of the catheter 10 is enhanced with multiple balloons separated by interruptions which provide natural flex points for the catheter. When the balloons experience the high perfusion pressure) they become more stiffs. The reduced diameter interruptions provide for increased flexibility at these joints.
  • Additional flexibility can be derived by providing the shaft [0066] 40 with variable stiffness. This variability can be produced by different materials forming the shaft 40 along its length or alternatively, tapering or otherwise varying the diameter of the shaft 40. For example, the shaft 40 can be progressively tampered from its proximal end 43 to its distal end 45 in order to provide a softer and more flexible heat exchange region 47.
  • With the intent of maximizing heat transfer with the body fluid in a conduit feeding a specific region of the body, any of the factors previously noted can be addressed to provide structural modifications to the foregoing embodiments. Of course changes in the material or size of any of the structural elements described car be varied to achieve various neat exchange properties. Realizing the many chances which might be contemplated, one is cautioned not to limit this concept only to the specific embodiments illustrated and disclosed, but rather to determine the scope of the invention with reference to the following claims. [0067]

Claims (47)

1. A catheter adapted to exchange heat with a body fluid flowing in a first direction through a body conduit, the catheter comprising:
a shaft having an axis extending between a proximal end and a distal end, the shaft having an input lumen and output lumen;
a heat exchange region disposed at the distal end of the shaft and including an outer surface;
the input lumen of the shaft being coupled to the heat exchange region at a first location, and the output lumen of the shaft being coupled to the heat exchange region at a second location so that a heat exchange fluid introduced into the first lumen will enter the heat exchange region at the first location and will exit the heat exchange region at the second location through the second lumen; and
the first location being disposed in the first direction relative to the second location when the catheter is operatively disposed in the body fluid.
2. The catheter recited in claim 1 wherein the second location is distal of the first location.
3. The catheter recited in claim 1, further comprising:
at least one balloon disposed in the heat exchange region and having an outer wall forming the outer surface, the balloon being adapted to receive the heat exchange fluid and to exchange heat across its outer wall with the body fluid.
4. The catheter recited in claim 3 wherein the heat exchange region includes:
a first balloon having a first flow of the heat exchange fluid;
a second balloon having a second flow of the heat exchange fluid; and
the first flow of the heat exchange fluid in the first balloon is balanced relative to the second flow of the heat exchange fluid in the second balloon.
5. The catheter recited in claim 3 wherein the balloon has an inner geometry which promotes mixing of the heat exchange fluid.
6. The catheter recited in claim 3 wherein the balloon has an outer geometry which promotes mixing of the body fluid.
7. A heat exchange catheter, comprising:
a shaft having an axis, a fluid inlet lumen, and a fluid outlet lumen each extending generally between a proximal end and a distal end of the shaft;
a hub disposed at the proximal end of the shaft and providing access to the fluid inlet lumen and the fluid outlet lumen;
a first balloon disposed at the distal end of the shaft and defining with the shaft an inflatable first cavity;
portions of the shaft define a first inlet hole extending in fluid communication between the fluid inlet lumen of the shaft and the first cavity of the first balloon;
portions of the shaft defining a first outlet hole extending in fluid communication between the first cavity and the fluid outlet lumen of the shaft;
a second balloon disposed relative to the first balloon at the distal end or the shaft and defining with the shaft an inflatable second cavity;
portions of the shaft defining a second inlet hole extending in fluid communication with the fluid inlet lumen of the shaft and the second cavity of the balloon; and
portions of the shaft defining a second outlet hole extending in fluid communication with the second cavity and the fluid outlet lumen.
8. The heat exchange catheter recited in claim 7 wherein the first balloon is disposed axially of the second balloon.
9. The heat exchange catheter recited in claim 8 wherein the first balloon is disposed distally of the second balloon; and
the first inlet hole is larger than the second inlet hole.
10. The heat exchange catheter recited in claim 8, wherein:
the first outlet hole is larger than the first inlet hole; and
the second outlet hole is larger than the second inlet hole.
11. The heat exchange catheter recited in claim 7, farther comprising:
an elastomeric covering disposed to cover a volume between the first balloon and the second balloon to facilitate laminar flow around the catheter.
12. The heat exchange catheter recited in claim 11 wherein the elastomeric covering comprises a third balloon disposed to cover the first balloon and the second balloon.
13. The heat exchange catheter recited in claim 7 wherein the first balloon is disposed radially of the second balloon.
14. The heat exchange catheter recited in claim 13 wherein the first outlet hole is larger than the first inlet hole.
15. The heat exchange catheter recited in claim 13 wherein the first inlet hole is disposed distally at the first outlet hole.
16. The catheter recited in claim 7 wherein portions of the catheter are provided with properties including thromboresistance.
17. The catheter recited in claim 16 wherein the thromboresistance properties are provided in the form of a coating having thromboresistant characteristics.
18. The catheter recited in claim 17 wherein the coating includes an anticoagulant.
19. The catheter recited in claim 16 wherein the thromboresistant properties are provided in the form of an electrical charge on the portions of the catheter.
20. A catheter adapted to be disposed in a body conduit to facilitate an exchange of heat between the catheter and a body fluid flowing in the body conduit, comprising:
a shaft having an axis, a first lumen, and a second lumen each extending generally between a proximal end and a distal end of the shaft;
a first sheet material disposed to define a first cavity exteriorly of the shaft;
a second sheet material disposed to define a second cavity exteriorly of the shaft;
portions of the shaft defining separate inlet holes providing fluid communication between the first lumen and each of the first cavity and the second cavity;
portions of the shaft defining separate outlet holes providing fluid communication between the second lumen and each of the first cavity and the second cavity; whereby
a heat exchange fluid can be introduced into the first lumen and through the outlet holes to the first and second cavities to facilitate the exchange of heat with the body fluid flowing in the body conduit.
21. The catheter recited in claim 20 wherein the body conduit is a vessel and the body fluid is blood.
22. The catheter recited in claim 21 wherein the vessel is an artery and the catheter is adapted to be operatively positioned in the artery with the blood flowing distally along the distal end of the catheter.
23. The catheter recited in claim 22 wherein the inlet hole is disposed distally of the outlet hole in the first cavity.
24. The catheter recited in claim 23 wherein the inlet hole associated with the first cavity is larger than the inlet hole associated with the second cavity.
25. The catheter recited in claim 21 wherein the vessel is a vein and the catheter is adapted to be operatively positioned within the vein with the blood flowing proximally along, distal end of the catheter.
26. The catheter recited in claim 25 wherein the inlet hole is disposed proximally of the outlet hole in the first cavity.
27. The catheter recited inclaim.26 wherein the inlet hole associated with the first cavity is larger than the inlet hole associated with the second cavity.
28. The catheter recited in claim 20 wherein the first cavity is formed by a first balloon extending circumferentially of the shaft;
the second cavity is formed by a second balloon extending circumferentially of the shaft distally of the first balloon.
29. A method for exchanging heat with a body fluid in a body conduit, comprising the steps of:
introducing into the body conduit a catheter having an inlet lumen and an outlet lumen;
providing the catheter with a first cavity in heat transfer relationship with the body fluid in the body conduit;
introducing a heat exchange fluid into the inlet lumen through an inlet hole and into the first cavity;
exchanging heat between the heat exchange fluid and the body fluid in the body conduit; and
removing the heat exchange fluid from each of the first cavity and the second cavity through an outlet hole and the outlet lumen.
30. The method recited in claim 29 wherein the introducing step includes the step of introducing the catheter into the body conduit in the direction of flow of the body fluid.
31. The method recited in claim 29 wherein the body conduit is an artery and the body fluid is blood.
32. The method recited in claim 29 wherein the introducing step includes the step of introducing the catheter into the body conduit against the direction of flow of the body fluid.
33. The method recited in claim 29 wherein the providing step includes the step of forming the outlet hole larger than the inlet hole.
34. The method recited in claim 29 wherein the providing step includes the step of positioning the outlet hole proximal of the inlet hole.
35. The method recited in claim 32 wherein the providing step includes the step of positioning the inlet hole proximally of the outlet hole.
36. The method recited in claim 29 wherein the providing step further comprises the step of positioning a first balloon exteriorly of the inlet lumen and the outlet lumen to form the first cavity.
37. The method recited in claim 36 wherein the providing step further comprises the steps of:
positioning a second balloon exteriorly of the inlet lumen and the outlet lumen to form the second cavity; and
positioning a third balloon to cover the first balloon and the second balloon.
38. The method recited in claim 29 wherein the step of exchanging heat includes the step of withdrawing heat from the body fluid to cool the body fluid.
39. A method for adjusting the temperature of a specific organ in a body system without significantly adjusting the temperature of other portions of the body system, the specific organ being coupled to a conduit which normally provides a flow of body fluid to the organ at a normal body temperature, the method comprising the steps of:
introducing into the body conduit a first fluid having a first temperature different than the body temperature or the body fluid;
introducing into the specific organ the body fluid and the first fluid having a combined temperature between the body temperature and the first temperature, to adjust the temperature of the specific organ;
controlling the first temperature of the first fluid in order to adjust the temperature of the specific organ without significantly adjusting the temperature of the remainder of the body system.
40. The method recited in claim 39 wherein the first temperature of the first fluid is less than the body temperature.
41. The method recited in claim 39 wherein the body fluid is blood.
42. The method recited in claim 39 wherein the specific organ is the brain.
43. The method recited in claim 39 wherein the conduit is the carotid artery.
44. The method recited in claim 39 wherein the body fluid is blood and the body conduit is an artery.
45. The method recited in claim 39 wherein the first fluid is a gas.
46. The method recited in claim 45 wherein the gas is an inert gas.
47. The method recited in claim 45 wherein the gas is carbon dioxide.
US10/127,209 1998-04-21 2002-04-22 Indwelling heat exchange catheter and method of using same Abandoned US20020151945A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US09/063,984 US6126684A (en) 1998-04-21 1998-04-21 Indwelling heat exchange catheter and method of using same
US09/546,814 US6416533B1 (en) 1998-04-21 2000-04-11 Indwelling heat exchange catheter and method of using same
US10/127,209 US20020151945A1 (en) 1998-04-21 2002-04-22 Indwelling heat exchange catheter and method of using same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/127,209 US20020151945A1 (en) 1998-04-21 2002-04-22 Indwelling heat exchange catheter and method of using same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/546,814 Continuation US6416533B1 (en) 1998-04-21 2000-04-11 Indwelling heat exchange catheter and method of using same

Publications (1)

Publication Number Publication Date
US20020151945A1 true US20020151945A1 (en) 2002-10-17

Family

ID=22052773

Family Applications (5)

Application Number Title Priority Date Filing Date
US09/063,984 Expired - Lifetime US6126684A (en) 1998-04-21 1998-04-21 Indwelling heat exchange catheter and method of using same
US09/503,014 Expired - Lifetime US6409747B1 (en) 1998-04-21 2000-02-11 Indwelling heat exchange catheter and method of using same
US09/546,814 Expired - Lifetime US6416533B1 (en) 1998-04-21 2000-04-11 Indwelling heat exchange catheter and method of using same
US10/127,209 Abandoned US20020151945A1 (en) 1998-04-21 2002-04-22 Indwelling heat exchange catheter and method of using same
US10/138,290 Expired - Lifetime US6755851B2 (en) 1998-04-21 2002-05-02 Indwelling heat exchange catheter and method of using same

Family Applications Before (3)

Application Number Title Priority Date Filing Date
US09/063,984 Expired - Lifetime US6126684A (en) 1998-04-21 1998-04-21 Indwelling heat exchange catheter and method of using same
US09/503,014 Expired - Lifetime US6409747B1 (en) 1998-04-21 2000-02-11 Indwelling heat exchange catheter and method of using same
US09/546,814 Expired - Lifetime US6416533B1 (en) 1998-04-21 2000-04-11 Indwelling heat exchange catheter and method of using same

Family Applications After (1)

Application Number Title Priority Date Filing Date
US10/138,290 Expired - Lifetime US6755851B2 (en) 1998-04-21 2002-05-02 Indwelling heat exchange catheter and method of using same

Country Status (3)

Country Link
US (5) US6126684A (en)
AU (1) AU3593900A (en)
WO (1) WO2000047145A1 (en)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
US6595967B2 (en) 2001-02-01 2003-07-22 Innercool Therapies, Inc. Collapsible guidewire lumen
US6648908B2 (en) 1998-01-23 2003-11-18 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US7951183B2 (en) 1998-01-23 2011-05-31 Innercool Therapies, Inc. Medical procedure
US8672988B2 (en) 2004-10-22 2014-03-18 Medtronic Cryocath Lp Method and device for local cooling within an organ using an intravascular device
US20150359976A1 (en) * 2013-01-31 2015-12-17 Smiths Medical International Limited Medical infusion fluid heat exchange apparatus and warming systems
WO2016033374A1 (en) * 2014-08-27 2016-03-03 Tva Medical, Inc. Cryolipopysis devices and methods therefor
US9320644B2 (en) 2011-07-25 2016-04-26 Neurosave, Inc. Non-invasive systems, devices, and methods for selective brain cooling
US10045817B2 (en) 2010-11-16 2018-08-14 Tva Medical, Inc. Devices and methods for forming a fistula

Families Citing this family (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6491039B1 (en) 1998-01-23 2002-12-10 Innercool Therapies, Inc. Medical procedure
US6471717B1 (en) 1998-03-24 2002-10-29 Innercool Therapies, Inc. Selective organ cooling apparatus and method
US6364899B1 (en) 1998-01-23 2002-04-02 Innercool Therapies, Inc. Heat pipe nerve cooler
US6096068A (en) 1998-01-23 2000-08-01 Innercool Therapies, Inc. Selective organ cooling catheter and method of using the same
US6558412B2 (en) 1998-01-23 2003-05-06 Innercool Therapies, Inc. Selective organ hypothermia method and apparatus
US6551349B2 (en) 1998-03-24 2003-04-22 Innercool Therapies, Inc. Selective organ cooling apparatus
US6312452B1 (en) 1998-01-23 2001-11-06 Innercool Therapies, Inc. Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US6830581B2 (en) 1999-02-09 2004-12-14 Innercool Therspies, Inc. Method and device for patient temperature control employing optimized rewarming
US6576002B2 (en) 1998-03-24 2003-06-10 Innercool Therapies, Inc. Isolated selective organ cooling method and apparatus
US6245095B1 (en) 1998-03-24 2001-06-12 Innercool Therapies, Inc. Method and apparatus for location and temperature specific drug action such as thrombolysis
US6251129B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control
US6251130B1 (en) 1998-03-24 2001-06-26 Innercool Therapies, Inc. Device for applications of selective organ cooling
US7288109B2 (en) 2002-04-04 2007-10-30 Innercool Therapies. Inc. Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US6599312B2 (en) 1998-03-24 2003-07-29 Innercool Therapies, Inc. Isolated selective organ cooling apparatus
US6464716B1 (en) 1998-01-23 2002-10-15 Innercool Therapies, Inc. Selective organ cooling apparatus and method
US6702841B2 (en) * 1998-01-23 2004-03-09 Innercool Therapies, Inc. Method of manufacturing a heat transfer element for in vivo cooling
US6491716B2 (en) 1998-03-24 2002-12-10 Innercool Therapies, Inc. Method and device for applications of selective organ cooling
US6238428B1 (en) 1998-01-23 2001-05-29 Innercool Therapies, Inc. Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations
US6051019A (en) 1998-01-23 2000-04-18 Del Mar Medical Technologies, Inc. Selective organ hypothermia method and apparatus
US6905494B2 (en) 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US7291144B2 (en) 1998-03-31 2007-11-06 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6602276B2 (en) 1998-03-31 2003-08-05 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6231595B1 (en) 1998-03-31 2001-05-15 Innercool Therapies, Inc. Circulating fluid hypothermia method and apparatus
US6530946B1 (en) 1998-04-21 2003-03-11 Alsius Corporation Indwelling heat exchange heat pipe catheter and method of using same
US6520933B1 (en) 1998-04-21 2003-02-18 Alsius Corporation Central venous line cooling catheter having a spiral-shaped heat exchange member
US6645234B2 (en) 1998-04-21 2003-11-11 Alsius Corporation Cardiovascular guiding catheter with heat exchange properties and methods of use
US6716236B1 (en) 1998-04-21 2004-04-06 Alsius Corporation Intravascular catheter with heat exchange element having inner inflation element and methods of use
US6419643B1 (en) 1998-04-21 2002-07-16 Alsius Corporation Central venous catheter with heat exchange properties
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US6126684A (en) 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6450990B1 (en) * 1998-08-13 2002-09-17 Alsius Corporation Catheter with multiple heating/cooling fibers employing fiber spreading features
US6338727B1 (en) * 1998-08-13 2002-01-15 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6620189B1 (en) 2000-02-28 2003-09-16 Radiant Medical, Inc. Method and system for control of a patient's body temperature by way of a transluminally insertable heat exchange catheter
US6610083B2 (en) 1998-08-24 2003-08-26 Radiant Medical, Inc. Multiple lumen heat exchange catheters
US6620188B1 (en) * 1998-08-24 2003-09-16 Radiant Medical, Inc. Methods and apparatus for regional and whole body temperature modification
US6146411A (en) 1998-12-24 2000-11-14 Alsius Corporation Cooling system for indwelling heat exchange catheter
US8506519B2 (en) 1999-02-16 2013-08-13 Flowcardia, Inc. Pre-shaped therapeutic catheter
US6554797B1 (en) 1999-02-19 2003-04-29 Alsius Corporation Method and system for patient temperature management and central venous access
US6458150B1 (en) 1999-02-19 2002-10-01 Alsius Corporation Method and apparatus for patient temperature control
US6460544B1 (en) 1999-03-11 2002-10-08 Alsius Corporation Method and apparatus for establishing and maintaining therapeutic hypothemia
US6299599B1 (en) * 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6149670A (en) * 1999-03-11 2000-11-21 Alsius Corporation Method and system for treating cardiac arrest using hypothermia
US6585692B1 (en) * 1999-02-19 2003-07-01 Alsius Corporation Method and system for patient temperature management and central venous access
US6726710B2 (en) 1999-08-16 2004-04-27 Alsius Corporation Method and system for treating cardiac arrest using hypothermia
US6436071B1 (en) * 1999-06-08 2002-08-20 The Trustees Of Columbia University In The City Of New York Intravascular systems for corporeal cooling
US6264679B1 (en) * 1999-08-20 2001-07-24 Radiant Medical, Inc. Heat exchange catheter with discrete heat exchange elements
US6575966B2 (en) * 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
US6325818B1 (en) 1999-10-07 2001-12-04 Innercool Therapies, Inc. Inflatable cooling apparatus for selective organ hypothermia
WO2001041708A2 (en) * 1999-12-07 2001-06-14 Alsius Corporation Method and system for treating stroke using hypothermia
AU4523301A (en) * 1999-12-14 2001-06-25 Radiant Medical, Inc. Method for reducing myocardial infarct by applicaton of intravascular hypothermia
US6638424B2 (en) * 2000-01-19 2003-10-28 Jensen Enterprises Stormwater treatment apparatus
AU2006200081B2 (en) * 2000-02-09 2009-08-27 Radiant Medical, Inc. Multiple lumen heat exchange catheters
US6379378B1 (en) 2000-03-03 2002-04-30 Innercool Therapies, Inc. Lumen design for catheter
US6648906B2 (en) 2000-04-06 2003-11-18 Innercool Therapies, Inc. Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid
US6592612B1 (en) * 2000-05-04 2003-07-15 Cardeon Corporation Method and apparatus for providing heat exchange within a catheter body
US6383210B1 (en) 2000-06-02 2002-05-07 Innercool Therapies, Inc. Method for determining the effective thermal mass of a body or organ using cooling catheter
US6726708B2 (en) 2000-06-14 2004-04-27 Innercool Therapies, Inc. Therapeutic heating and cooling via temperature management of a colon-inserted balloon
US6537271B1 (en) * 2000-07-06 2003-03-25 Cryogen, Inc. Balloon cryogenic catheter
US20040034321A1 (en) * 2000-10-05 2004-02-19 Seacoast Technologies, Inc. Conformal pad for neurosurgery and method thereof
CA2425059A1 (en) 2000-10-05 2002-04-11 Seacoast Technologies, Inc. Neurosurgical device for thermal therapy including spiral element
US6719779B2 (en) 2000-11-07 2004-04-13 Innercool Therapies, Inc. Circulation set for temperature-controlled catheter and method of using the same
CA2465435A1 (en) * 2000-11-07 2002-07-18 Innercool Therapies, Inc. Fever regulation method and apparatus
US6719723B2 (en) 2000-12-06 2004-04-13 Innercool Therapies, Inc. Multipurpose catheter assembly
US6602243B2 (en) * 2000-12-15 2003-08-05 Alsius Corporation Foley catheter having redundant temperature sensors and method
WO2002058606A1 (en) 2001-01-24 2002-08-01 Alsius Corporation Central venous catheter with heat exchange properties
US6648880B2 (en) 2001-02-16 2003-11-18 Cryocath Technologies Inc. Method of using cryotreatment to treat brain tissue
US6544282B1 (en) 2001-02-21 2003-04-08 Radiant Medical, Inc. Inhibition of platelet activation, aggregation and/or adhesion by hypothermia
US6451045B1 (en) * 2001-02-22 2002-09-17 Alsius Corporation Heat exchange catheter having a helically wrapped heat exchanger
US6709448B2 (en) 2001-04-13 2004-03-23 Alsius Corporation Open core heat exchange catheter, system and method
US6641603B2 (en) 2001-04-13 2003-11-04 Alsius Corporation Heat exchange catheter having helically wound reinforcement
US6430956B1 (en) * 2001-05-15 2002-08-13 Cimex Biotech Lc Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore
US6752786B2 (en) * 2001-05-31 2004-06-22 Radiant Medical, Inc. Moving heat exchange catheter system
US20030053669A1 (en) * 2001-07-18 2003-03-20 Marconi Medical Systems, Inc. Magnetic resonance angiography method and apparatus
US20070213793A1 (en) * 2001-08-06 2007-09-13 Radiant Medical, Inc. Use of endovascular hypothermia in organ and/or tissue transplantations
US6581403B2 (en) 2001-09-25 2003-06-24 Alsius Corporation Heating/cooling system for indwelling heat exchange catheter
US7287398B2 (en) * 2001-09-25 2007-10-30 Alsius Corporation Heating/cooling system for indwelling heat exchange catheter
US7912554B2 (en) * 2001-09-26 2011-03-22 Medtronic Cryocath Lp Method for treatment of aneurysms
US6736809B2 (en) * 2001-09-26 2004-05-18 Cryocath Technologies Inc. Method and device for treatment of aneurysms
US20040249372A1 (en) * 2001-09-26 2004-12-09 Leonilda Capuano Method for treatment of aneurysms
US6645233B1 (en) * 2001-09-27 2003-11-11 Gregory M. Ayers Drainage tube with heat transfer function and methods of use
US6800068B1 (en) 2001-10-26 2004-10-05 Radiant Medical, Inc. Intra-aortic balloon counterpulsation with concurrent hypothermia
US7144418B1 (en) * 2001-11-02 2006-12-05 Medcool, Inc. Method, and system for selective cerebral hypothermia
US6572640B1 (en) * 2001-11-21 2003-06-03 Alsius Corporation Method and apparatus for cardiopulmonary bypass patient temperature control
US20030153905A1 (en) * 2002-01-25 2003-08-14 Edwards Stuart Denzil Selective ablation system
US6702783B1 (en) * 2002-02-05 2004-03-09 Radiant Medical, Inc. Endovascular heat-and gas-exchange catheter device and related methods
US6758836B2 (en) 2002-02-07 2004-07-06 C. R. Bard, Inc. Split tip dialysis catheter
US7087026B2 (en) * 2002-03-21 2006-08-08 Radiant Medical, Inc. Devices and methods for measuring blood flow rate or cardiac output and for heating or cooling the body
US6685733B1 (en) * 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
US7144407B1 (en) * 2002-05-30 2006-12-05 Alsius Corporation Cardiovascular intra aortic balloon pump catheter with heat exchange function and methods of use
US6833003B2 (en) * 2002-06-24 2004-12-21 Cordis Neurovascular Expandable stent and delivery system
US6855123B2 (en) 2002-08-02 2005-02-15 Flow Cardia, Inc. Therapeutic ultrasound system
US20040039430A1 (en) 2002-08-20 2004-02-26 Xanodyne Pharmacal, Inc. System and method using the rectal mucosal membrane for inducing hypothermia and warming
US7137963B2 (en) 2002-08-26 2006-11-21 Flowcardia, Inc. Ultrasound catheter for disrupting blood vessel obstructions
US7186222B1 (en) 2002-09-10 2007-03-06 Radiant Medical, Inc. Vascular introducer with temperature monitoring probe and systems for endovascular temperature control
US7758510B2 (en) 2003-09-19 2010-07-20 Flowcardia, Inc. Connector for securing ultrasound catheter to transducer
US7001422B2 (en) * 2002-09-23 2006-02-21 Cordis Neurovascular, Inc Expandable stent and delivery system
US7604608B2 (en) 2003-01-14 2009-10-20 Flowcardia, Inc. Ultrasound catheter and methods for making and using same
US20040167466A1 (en) * 2003-02-21 2004-08-26 Drasler William J. Delivering cooled fluid to sites inside the body
US7393339B2 (en) 2003-02-21 2008-07-01 C. R. Bard, Inc. Multi-lumen catheter with separate distal tips
US20040167467A1 (en) * 2003-02-21 2004-08-26 Kent Harrison Delivering cooled fluid to sites inside the body
US7300453B2 (en) * 2003-02-24 2007-11-27 Innercool Therapies, Inc. System and method for inducing hypothermia with control and determination of catheter pressure
US6942677B2 (en) 2003-02-26 2005-09-13 Flowcardia, Inc. Ultrasound catheter apparatus
US20040199114A1 (en) * 2003-04-01 2004-10-07 Alsius Corporation Intravascular heat exchange catheter with tissue preservative
US7220233B2 (en) 2003-04-08 2007-05-22 Flowcardia, Inc. Ultrasound catheter devices and methods
US7118591B2 (en) * 2003-04-17 2006-10-10 The University Of Chicago Heat transfer probe
US20040215177A1 (en) 2003-04-24 2004-10-28 Scimed Life Systems, Inc. Therapeutic apparatus having insulated region at the insertion area
US6893454B2 (en) * 2003-04-28 2005-05-17 Alsius Corporation Intrarectal heat exchange catheter
US20040243095A1 (en) 2003-05-27 2004-12-02 Shekhar Nimkar Methods and apparatus for inserting multi-lumen spit-tip catheters into a blood vessel
US20040267338A1 (en) * 2003-06-25 2004-12-30 Kent Harrison Targeted tissue cooling within a body
WO2005037193A2 (en) * 2003-10-03 2005-04-28 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor administered under hypothermic conditions for the treatment of ischemic mediated central nervous system disorders or injury
US7326195B2 (en) * 2003-11-18 2008-02-05 Boston Scientific Scimed, Inc. Targeted cooling of tissue within a body
US7335180B2 (en) 2003-11-24 2008-02-26 Flowcardia, Inc. Steerable ultrasound catheter
JP4391221B2 (en) * 2003-12-22 2009-12-24 有限会社日本エレクテル Frequency heating balloon catheter
US20060036302A1 (en) * 2004-05-28 2006-02-16 Kasza Kenneth E Methods of inducing protective hypothermia of organs
US8992454B2 (en) 2004-06-09 2015-03-31 Bard Access Systems, Inc. Splitable tip catheter with bioresorbable adhesive
US20060025840A1 (en) * 2004-08-02 2006-02-02 Martin Willard Cooling tissue inside the body
US7540852B2 (en) 2004-08-26 2009-06-02 Flowcardia, Inc. Ultrasound catheter devices and methods
US20060058859A1 (en) * 2004-09-16 2006-03-16 Merrill Thomas L Cooling catheter and method with adjunctive therapy capability
US20060064146A1 (en) * 2004-09-17 2006-03-23 Collins Kenneth A Heating/cooling system for indwelling heat exchange catheter
US7399291B2 (en) * 2004-12-02 2008-07-15 Syntheon, Llc. Catheter for treatment of total occlusions and methods for manufacture and use of the catheter
US20060161232A1 (en) * 2005-01-18 2006-07-20 Kasza, Oras and Son to The University of Chicago Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices
US8221343B2 (en) 2005-01-20 2012-07-17 Flowcardia, Inc. Vibrational catheter devices and methods for making same
US7789846B2 (en) 2005-01-25 2010-09-07 Thermopeutix, Inc. System and methods for selective thermal treatment
US7892269B2 (en) 2005-04-18 2011-02-22 Zoll Circulation, Inc. External heat exchange pad for patient
US20060190062A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for reducing shivering when using external cooling pads
US20060190066A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for bringing hypothermia rapidly onboard
US7070612B1 (en) 2005-02-23 2006-07-04 Alsius Corporation System and method for bringing hypothermia rapidly onboard
US7425216B2 (en) 2005-03-01 2008-09-16 Alsius Corporation System and method for treating cardiac arrest and myocardial infarction
US7674256B2 (en) * 2005-03-17 2010-03-09 Boston Scientific Scimed, Inc. Treating internal body tissue
AU2006239290B2 (en) * 2005-04-27 2012-05-10 Zoll Circulation, Inc. System for adjusting the temperature of a patient
US20060276864A1 (en) * 2005-06-03 2006-12-07 Alsius Corporation Systems and methods for sensing patient temperature in temperature management system
US20060293732A1 (en) * 2005-06-27 2006-12-28 Collins Kenneth A Thermoelectric cooler (TEC) heat exchanger for intravascular heat exchange catheter
US7181927B2 (en) 2005-07-01 2007-02-27 Alsius Corporation Primary heat exchanger for patient temperature control
US7951182B2 (en) 2005-07-14 2011-05-31 Zoll Circulation, Inc. System and method for leak detection in external cooling pad
US7963940B2 (en) * 2005-08-22 2011-06-21 Boston Scientific Scimed, Inc. Local perfusion device
US7389653B2 (en) * 2005-09-15 2008-06-24 The University Of Chicago Medical ice slurry production device
US7572268B2 (en) 2005-10-13 2009-08-11 Bacoustics, Llc Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy
US7842032B2 (en) 2005-10-13 2010-11-30 Bacoustics, Llc Apparatus and methods for the selective removal of tissue
US20070088386A1 (en) * 2005-10-18 2007-04-19 Babaev Eilaz P Apparatus and method for treatment of soft tissue injuries
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
US9937332B2 (en) * 2006-02-06 2018-04-10 Medtronic Cryocath Lp Cryo-perfusion balloon device
US9282984B2 (en) 2006-04-05 2016-03-15 Flowcardia, Inc. Therapeutic ultrasound system
US20080039727A1 (en) * 2006-08-08 2008-02-14 Eilaz Babaev Ablative Cardiac Catheter System
US7822485B2 (en) 2006-09-25 2010-10-26 Zoll Circulation, Inc. Method and apparatus for spinal cooling
US8246643B2 (en) 2006-11-07 2012-08-21 Flowcardia, Inc. Ultrasound catheter having improved distal end
US8133236B2 (en) 2006-11-07 2012-03-13 Flowcardia, Inc. Ultrasound catheter having protective feature against breakage
US7867266B2 (en) 2006-11-13 2011-01-11 Zoll Circulation, Inc. Temperature management system with assist mode for use with heart-lung machine
US7892270B2 (en) 2006-11-21 2011-02-22 Zoll Circulation Inc. Temperature management system and method for burn patients
US8353893B2 (en) 2007-03-07 2013-01-15 Zoll Circulation, Inc. System and method for rapidly cooling cardiac arrest patient
JP2010523230A (en) 2007-04-05 2010-07-15 ベロメディックス,インク Automatic treatment system and method
US9737692B2 (en) 2007-05-18 2017-08-22 Zoll Circulation, Inc. System and method for effecting non-standard fluid line connections
AU2008275158A1 (en) 2007-07-09 2009-01-15 Velomedix, Inc Hypothermia devices and methods
US8475509B2 (en) 2007-08-09 2013-07-02 Zoll Circulation, Inc. Devices and methods for using endovascular cooling to treat septic shock and other disorders
EP2214765A4 (en) 2007-10-17 2011-08-10 Bard Access Systems Inc Manufacture of split tip catheters
US8292841B2 (en) 2007-10-26 2012-10-23 C. R. Bard, Inc. Solid-body catheter including lateral distal openings
US8066660B2 (en) 2007-10-26 2011-11-29 C. R. Bard, Inc. Split-tip catheter including lateral distal openings
US9579485B2 (en) 2007-11-01 2017-02-28 C. R. Bard, Inc. Catheter assembly including a multi-lumen configuration
JP5452498B2 (en) 2007-11-01 2014-03-26 シー・アール・バード・インコーポレーテッドC R Bard Incorporated Catheter assembly including triple lumen end
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US8226566B2 (en) 2009-06-12 2012-07-24 Flowcardia, Inc. Device and method for vascular re-entry
WO2011130536A2 (en) * 2010-04-14 2011-10-20 Northwestern University Triple balloon occlusion and infusion catheter
US9622670B2 (en) 2010-07-09 2017-04-18 Potrero Medical, Inc. Method and apparatus for pressure measurement
GB201021898D0 (en) * 2010-12-23 2011-02-02 Albalat Alberto M Fluid circulation system
US9554822B2 (en) * 2011-09-02 2017-01-31 Abbott Cardiovascular Systems Inc. Thrombectomy catheter with aspiration and guidewire lumens defining an asymmetrical taper and cutting edge with offset tip
US9283110B2 (en) 2011-09-20 2016-03-15 Zoll Circulation, Inc. Patient temperature control catheter with outer sleeve cooled by inner sleeve
US9259348B2 (en) 2011-09-28 2016-02-16 Zoll Circulation, Inc. Transatrial patient temperature control catheter
US10045881B2 (en) 2011-09-28 2018-08-14 Zoll Circulation, Inc. Patient temperature control catheter with helical heat exchange paths
US9314370B2 (en) 2011-09-28 2016-04-19 Zoll Circulation, Inc. Self-centering patient temperature control catheter
US8888832B2 (en) 2011-09-28 2014-11-18 Zoll Circulation, Inc. System and method for doubled use of patient temperature control catheter
ES2626055T3 (en) 2011-09-30 2017-07-21 Zoll Circulation, Inc. Heat exchange catheters with bidirectional fluid flow
WO2013109269A1 (en) 2012-01-18 2013-07-25 Bard Peripheral Vascular, Inc. Vascular re-entry device
US9717625B2 (en) 2012-09-28 2017-08-01 Zoll Circulation, Inc. Intravascular heat exchange catheter with non-round coiled coolant path
US9801756B2 (en) 2012-09-28 2017-10-31 Zoll Circulation, Inc. Intravascular heat exchange catheter and system with RFID coupling
US9241827B2 (en) 2012-09-28 2016-01-26 Zoll Circulation, Inc. Intravascular heat exchange catheter with multiple spaced apart discrete coolant loops
US9433528B2 (en) 2012-09-28 2016-09-06 Zoll Circulation, Inc. Intravascular heat exchange catheter with rib cage-like coolant path
KR101598546B1 (en) 2012-10-01 2016-02-29 씨. 알. 바드, 인크. Balloon catheter having multiple inflation lumens and related methods
US9278023B2 (en) 2012-12-14 2016-03-08 Zoll Circulation, Inc. System and method for management of body temperature
USD748252S1 (en) 2013-02-08 2016-01-26 C. R. Bard, Inc. Multi-lumen catheter tip
US9474644B2 (en) 2014-02-07 2016-10-25 Zoll Circulation, Inc. Heat exchange system for patient temperature control with multiple coolant chambers for multiple heat exchange modalities
US9709609B2 (en) 2014-07-14 2017-07-18 Covidien Lp Systems and methods for improving the range of sensor systems
WO2016011091A1 (en) 2014-07-14 2016-01-21 C. R. Bard, Inc. Apparatuses, systems, and methods for inserting split tip catheters having enhanced stiffening and guiding features
US9784263B2 (en) 2014-11-06 2017-10-10 Zoll Circulation, Inc. Heat exchange system for patient temperature control with easy loading high performance peristaltic pump
US10022265B2 (en) 2015-04-01 2018-07-17 Zoll Circulation, Inc. Working fluid cassette with hinged plenum or enclosure for interfacing heat exchanger with intravascular temperature management catheter

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125096A (en) * 1964-03-17 Compressor
US2058780A (en) * 1931-03-28 1936-10-27 Elliott Charles Robert Thermo-therapeutical method and apparatus
US2077453A (en) * 1934-03-29 1937-04-20 American Anode Inc Therapeutical appliance
US2190384A (en) 1937-07-06 1940-02-13 Louis B Newman Therapeutic bag
US3140716A (en) 1961-06-26 1964-07-14 Baxter Laboratories Inc Heat exchanger for blood
US3142158A (en) * 1962-05-28 1964-07-28 Podolsky Leon Thermoelectric cooling device
US3238944A (en) * 1962-10-08 1966-03-08 Max L Hirschhorn Temperature controlling device for living organs
US3425419A (en) * 1964-08-08 1969-02-04 Angelo Actis Dato Method of lowering and raising the temperature of the human body
US3504674A (en) * 1966-12-22 1970-04-07 Emil S Swenson Method and apparatus for performing hypothermia
US3460538A (en) 1967-10-20 1969-08-12 Edward T Armstrong Hypothermia apparatus and method for treating the human body and the like
US3897790A (en) 1971-08-13 1975-08-05 Univ Iowa State Res Found Inc Method for controlling vascular responses
US3776241A (en) 1971-08-13 1973-12-04 Univ Iowa State Res Found Inc System and method for controlling vascular responses
US3738372A (en) 1972-01-13 1973-06-12 T Shioshvili Apparatus for application of local hypothermy to the kidney
GB1438759A (en) 1972-06-02 1976-06-09 Spembly Ltd Cryo-surgical apparatus
US4010795A (en) 1973-08-02 1977-03-08 Gambro Ag Cooling unit
US4119102A (en) 1975-07-11 1978-10-10 Leveen Harry H Radio frequency treatment of tumors while inducing hypotension
GB1582135A (en) 1976-07-14 1980-12-31 Ferranti Ltd Heaters
US4111209A (en) * 1977-04-18 1978-09-05 Datascope Corporation Topical hypothermia apparatus and method for treating the human body and the like
US4181132A (en) 1977-05-31 1980-01-01 Parks Leon C Method and apparatus for effecting hyperthermic treatment
US4154245A (en) 1977-07-11 1979-05-15 Daily Pat O Apparatus for local hypothermia
US4840617A (en) 1980-04-14 1989-06-20 Thomas Jefferson University Cerebral and lumbar perfusion catheterization apparatus for use in treating hypoxic/ischemic neurologic tissue
US4298006A (en) 1980-04-30 1981-11-03 Research Against Cancer, Inc. Systemic hyperthermia with improved temperature sensing apparatus and method
US4416281A (en) 1981-03-05 1983-11-22 Guardline Disposables Limited Surgical cushion for cooling an organ
EP0165523B1 (en) * 1981-03-28 1989-05-24 Yoshiro Nakamatsu Apparatus for measuring brain activity
JPS5957650A (en) 1982-09-27 1984-04-03 Kureha Chemical Ind Co Ltd Probe for heating body cavity
JPS6142621Y2 (en) 1982-10-25 1986-12-03
CA1255757C (en) 1983-01-24 1989-06-13
US4546759A (en) 1983-07-29 1985-10-15 Mladen Solar Method and apparatus for assisting human heart function
CA1251109A (en) * 1984-04-24 1989-03-14 Tohru Takemura Blood oxygenator using a hollow-fiber membrane
US4583969A (en) * 1984-06-26 1986-04-22 Mortensen J D Apparatus and method for in vivo extrapulmonary blood gas exchange
ZA8600080B (en) * 1985-01-08 1987-08-26 Mcneilab Inc Mass transfer device having a microporous,spirally wound hollow fiber membrane
US4707587A (en) 1986-01-27 1987-11-17 Greenblatt Gordon M Blood warming method and apparatus using gaseous heat exchange medium
US4920963A (en) * 1986-02-28 1990-05-01 Brader Eric W Apparatus for preventing brain damage during cardiac arrest, CPR or severe shock
US4745922A (en) * 1986-07-11 1988-05-24 Taylor Kenneth G Cervical heat transfer and immobilization device
US4754752A (en) 1986-07-28 1988-07-05 Robert Ginsburg Vascular catheter
US4958634A (en) * 1987-05-06 1990-09-25 Jang G David Limacon geometry balloon angioplasty catheter systems and method of making same
US5011468A (en) 1987-05-29 1991-04-30 Retroperfusion Systems, Inc. Retroperfusion and retroinfusion control apparatus, system and method
US5059167A (en) 1987-05-29 1991-10-22 Retroperfusion Systems, Inc. Retroperfusion and retroinfusion control apparatus, system and method
EP0524662B1 (en) * 1987-06-28 1997-11-12 Terumo Kabushiki Kaisha Method for manufacturing a medical heat exchanger
US4819655A (en) 1987-08-04 1989-04-11 Webler William E Injectateless thermal cardiac output determination method and apparatus
JPS6446056U (en) 1987-09-17 1989-03-22
US5041089A (en) 1987-12-11 1991-08-20 Devices For Vascular Intervention, Inc. Vascular dilation catheter construction
US4850958A (en) * 1988-06-08 1989-07-25 Cardiopulmonics, Inc. Apparatus and method for extrapulmonary blood gas exchange
US5262451A (en) * 1988-06-08 1993-11-16 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US4846177A (en) 1988-07-15 1989-07-11 Minnesota Mining And Manufacturing Company Combination fluid path and mount for heat exchanger
US5167960A (en) * 1988-08-03 1992-12-01 New England Deaconess Hospital Corporation Hirudin-coated biocompatible substance
US4941475A (en) * 1988-08-30 1990-07-17 Spectramed, Inc. Thermodilution by heat exchange
US5147355A (en) 1988-09-23 1992-09-15 Brigham And Womens Hospital Cryoablation catheter and method of performing cryoablation
US5151100A (en) 1988-10-28 1992-09-29 Boston Scientific Corporation Heating catheters
GB2226497B (en) * 1988-12-01 1992-07-01 Spembly Medical Ltd Cryosurgical probe
US5004461A (en) * 1989-03-23 1991-04-02 Wilson Joseph E Methods for rendering plastics thromboresistant and product
US4986809A (en) * 1989-04-17 1991-01-22 Hattler Brack G Percutaneous oxygenator
US4911689A (en) * 1989-04-17 1990-03-27 Hattler Brack G Percutaneous oxygenator
WO1991005528A1 (en) * 1989-10-19 1991-05-02 Granulab B.V. Device for cooling or heating a person
US5147385A (en) 1989-11-01 1992-09-15 Schneider (Europe) A.G. Stent and catheter for the introduction of the stent
US5098376A (en) * 1989-12-22 1992-03-24 Cardiopulmonics, Inc. Apparatus and methods for furling and introducing an extrapulmonary blood gas exchange device
IL93842A (en) 1990-03-22 1995-10-31 Argomed Ltd Apparatus for localized thermal treatment of mammals
US5549559A (en) 1990-03-22 1996-08-27 Argomed Ltd. Thermal treatment apparatus
US5098429A (en) 1990-04-17 1992-03-24 Mmtc, Inc. Angioplastic technique employing an inductively-heated ferrite material
US5624392A (en) 1990-05-11 1997-04-29 Saab; Mark A. Heat transfer catheters and methods of making and using same
US5037383A (en) * 1990-05-21 1991-08-06 Northwestern University Intravascular lung assist device and method
US5190540A (en) 1990-06-08 1993-03-02 Cardiovascular & Interventional Research Consultants, Inc. Thermal balloon angioplasty
US5135474A (en) 1990-08-03 1992-08-04 University Of Medicine And Dentistry Of New Jersey Hepatic bypass catheter
US5149321A (en) 1990-10-10 1992-09-22 Klatz Ronald M Brain resuscitation device and method for performing the same
US5395314A (en) 1990-10-10 1995-03-07 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5139496A (en) 1990-12-20 1992-08-18 Hed Aharon Z Ultrasonic freeze ablation catheters and probes
US5308320A (en) 1990-12-28 1994-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method
US5271743A (en) * 1991-03-27 1993-12-21 Hattler Brack G System to optimize the transfer of gas through membranes
US5122113A (en) * 1991-03-27 1992-06-16 Hattler Brack G Inflatable percutaneous oxygenator
US5207640A (en) * 1991-03-27 1993-05-04 Hattler Brack G Method of anesthetizing a patient
US5542928A (en) 1991-05-17 1996-08-06 Innerdyne, Inc. Method and device for thermal ablation having improved heat transfer
US5261399A (en) * 1991-05-22 1993-11-16 Klatz Ronald M Brain cooling device and method for performing the same
US5250070A (en) 1991-05-28 1993-10-05 Parodi Juan C Less traumatic angioplasty balloon for arterial dilatation
US5211631A (en) 1991-07-24 1993-05-18 Sheaff Charles M Patient warming apparatus
US5261411A (en) 1991-12-27 1993-11-16 Abbott Laboratories Thermal drift correction while continuously monitoring cardiac output
US5304214A (en) * 1992-01-21 1994-04-19 Med Institute, Inc. Transurethral ablation catheter
US5281215A (en) 1992-04-16 1994-01-25 Implemed, Inc. Cryogenic catheter
US5281213A (en) 1992-04-16 1994-01-25 Implemed, Inc. Catheter for ice mapping and ablation
US5423807A (en) 1992-04-16 1995-06-13 Implemed, Inc. Cryogenic mapping and ablation catheter
US5269758A (en) * 1992-04-29 1993-12-14 Taheri Syde A Intravascular catheter and method for treatment of hypothermia
US5248312A (en) 1992-06-01 1993-09-28 Sensor Electronics, Inc. Liquid metal-filled balloon
US5871526A (en) 1993-10-13 1999-02-16 Gibbs; Roselle Portable temperature control system
US5275595A (en) 1992-07-06 1994-01-04 Dobak Iii John D Cryosurgical instrument
NL9201222A (en) 1992-07-08 1994-02-01 Marinus Adrianus Josephus Mari Return Cannula.
US5342301A (en) 1992-08-13 1994-08-30 Advanced Polymers Incorporated Multi-lumen balloons and catheters made therewith
US5354277A (en) * 1992-09-04 1994-10-11 Biocontrol Technology, Inc. Specialized perfusion protocol for whole-body hyperthermia
US5403281A (en) 1992-09-25 1995-04-04 Minnesota Mining And Manufacturing Company Inline heat exchanger and cardioplegia system
US5348554A (en) 1992-12-01 1994-09-20 Cardiac Pathways Corporation Catheter for RF ablation with cooled electrode
US5545161A (en) 1992-12-01 1996-08-13 Cardiac Pathways Corporation Catheter for RF ablation having cooled electrode with electrically insulated sleeve
US5324286A (en) 1993-01-21 1994-06-28 Arthur A. Fowle, Inc. Entrained cryogenic droplet transfer method and cryosurgical instrument
IL104506A (en) 1993-01-25 1997-11-20 Israel State Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use
US5437673A (en) * 1993-02-04 1995-08-01 Cryomedical Sciences, Inc. Closed circulation tissue warming apparatus and method of using the same in prostate surgery
US6110168A (en) 1993-02-10 2000-08-29 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modifications
US5837003A (en) * 1993-02-10 1998-11-17 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US5486208A (en) * 1993-02-10 1996-01-23 Ginsburg; Robert Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5693080A (en) 1993-03-19 1997-12-02 Wallsten Medical S.A. Apparatus for medical treatment
US5607463A (en) * 1993-03-30 1997-03-04 Medtronic, Inc. Intravascular medical device
US5346508A (en) 1993-04-29 1994-09-13 Scimed Life Systems, Inc. Apparatus and method for performing diagnostics and intravascular therapies
US5501663A (en) * 1993-07-02 1996-03-26 Medtronic Electromedics, Inc. Inflatable percutaneous oxygenator with transverse hollow fibers
US5464437A (en) 1993-07-08 1995-11-07 Urologix, Inc. Benign prostatic hyperplasia treatment catheter with urethral cooling
US5405322A (en) 1993-08-12 1995-04-11 Boston Scientific Corporation Method for treating aneurysms with a thermal source
US5807395A (en) 1993-08-27 1998-09-15 Medtronic, Inc. Method and apparatus for RF ablation and hyperthermia
US5716386A (en) * 1994-06-27 1998-02-10 The Ohio State University Non-invasive aortic impingement and core and cerebral temperature manipulation
US5626618A (en) * 1993-09-24 1997-05-06 The Ohio State University Mechanical adjunct to cardiopulmonary resuscitation (CPR), and an electrical adjunct to defibrillation countershock, cardiac pacing, and cardiac monitoring
US5415654A (en) * 1993-10-05 1995-05-16 S.L.T. Japan Co., Ltd. Laser balloon catheter apparatus
GB2283678B (en) 1993-11-09 1998-06-03 Spembly Medical Ltd Cryosurgical catheter probe
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5452582A (en) 1994-07-06 1995-09-26 Apd Cryogenics, Inc. Cryo-probe
US5486204A (en) 1994-09-20 1996-01-23 University Of Texas Health Science Center Houston Method of treating a non-penetrating head wound with hypothermia
US5957917A (en) 1995-01-20 1999-09-28 Miravant Systems, Inc. Transluminal hyperthermia catheter and method for use
US5609620A (en) 1995-06-06 1997-03-11 Pat O. Daily Cardiac cooling jacket
US5758505C1 (en) * 1995-10-12 2001-10-30 Cryogen Inc Precooling system for joule-thomson probe
US5787715A (en) * 1995-10-12 1998-08-04 Cryogen, Inc. Mixed gas refrigeration method
US5876667A (en) 1996-01-11 1999-03-02 Medtronic, Inc. Blood heat exchange system employing micro-conduit
US5733319A (en) 1996-04-25 1998-03-31 Urologix, Inc. Liquid coolant supply system
US5861021A (en) 1996-06-17 1999-01-19 Urologix Inc Microwave thermal therapy of cardiac tissue
US5800486A (en) 1996-06-17 1998-09-01 Urologix, Inc. Device for transurethral thermal therapy with cooling balloon
US5975081A (en) 1996-06-21 1999-11-02 Northrop Grumman Corporation Self-contained transportable life support system
US5797948A (en) 1996-10-03 1998-08-25 Cordis Corporation Centering balloon catheter
US5916242A (en) * 1996-11-04 1999-06-29 Schwartz; George R. Apparatus for rapid cooling of the brain and method of performing same
US6033383A (en) * 1996-12-19 2000-03-07 Ginsburg; Robert Temperature regulating catheter and methods
US5899898A (en) 1997-02-27 1999-05-04 Cryocath Technologies Inc. Cryosurgical linear ablation
US5868735A (en) 1997-03-06 1999-02-09 Scimed Life Systems, Inc. Cryoplasty device and method
US5879347A (en) 1997-04-25 1999-03-09 Gynecare, Inc. Apparatus for controlled thermal treatment of tissue
US5902299A (en) 1997-07-29 1999-05-11 Jayaraman; Swaminathan Cryotherapy method for reducing tissue injury after balloon angioplasty or stent implantation
AU1190699A (en) 1997-10-20 1999-05-10 Robert D. Bersin Helical spiral balloon catheter
US6051019A (en) * 1998-01-23 2000-04-18 Del Mar Medical Technologies, Inc. Selective organ hypothermia method and apparatus
US6042559A (en) 1998-02-24 2000-03-28 Innercool Therapies, Inc. Insulated catheter for selective organ perfusion
US6126684A (en) 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6338727B1 (en) 1998-08-13 2002-01-15 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6146411A (en) 1998-12-24 2000-11-14 Alsius Corporation Cooling system for indwelling heat exchange catheter
US6405080B1 (en) 1999-03-11 2002-06-11 Alsius Corporation Method and system for treating cardiac arrest
US6299599B1 (en) 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6019783A (en) 1999-03-02 2000-02-01 Alsius Corporation Cooling system for therapeutic catheter
US6231594B1 (en) 1999-08-11 2001-05-15 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7766949B2 (en) 1998-01-23 2010-08-03 Innercool Therapies, Inc. Fever regulation method and apparatus
US7951183B2 (en) 1998-01-23 2011-05-31 Innercool Therapies, Inc. Medical procedure
US6648908B2 (en) 1998-01-23 2003-11-18 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6676689B2 (en) 1998-01-23 2004-01-13 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6695873B2 (en) 1998-01-23 2004-02-24 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US7651518B2 (en) 1998-01-23 2010-01-26 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
US6595967B2 (en) 2001-02-01 2003-07-22 Innercool Therapies, Inc. Collapsible guidewire lumen
US8672988B2 (en) 2004-10-22 2014-03-18 Medtronic Cryocath Lp Method and device for local cooling within an organ using an intravascular device
US10045817B2 (en) 2010-11-16 2018-08-14 Tva Medical, Inc. Devices and methods for forming a fistula
US9320644B2 (en) 2011-07-25 2016-04-26 Neurosave, Inc. Non-invasive systems, devices, and methods for selective brain cooling
US20150359976A1 (en) * 2013-01-31 2015-12-17 Smiths Medical International Limited Medical infusion fluid heat exchange apparatus and warming systems
US10363381B2 (en) * 2013-01-31 2019-07-30 Smiths Medical International Limited Medical infusion fluid heat exchange apparatus and warming systems
WO2016033374A1 (en) * 2014-08-27 2016-03-03 Tva Medical, Inc. Cryolipopysis devices and methods therefor

Also Published As

Publication number Publication date
US6126684A (en) 2000-10-03
US6755851B2 (en) 2004-06-29
US6409747B1 (en) 2002-06-25
WO2000047145A9 (en) 2001-05-17
WO2000047145A8 (en) 2001-03-22
AU3593900A (en) 2000-08-29
WO2000047145A1 (en) 2000-08-17
US20020169490A1 (en) 2002-11-14
US6416533B1 (en) 2002-07-09

Similar Documents

Publication Publication Date Title
US6251129B1 (en) Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control
US6974463B2 (en) System and method for patient temperature control employing temperature projection algorithm
US6818011B2 (en) Circulating fluid hypothermia method and apparatus
AU756115B2 (en) Temperature regulating catheter and methods
US7998182B2 (en) Selective organ cooling apparatus
US7150737B2 (en) Methods and apparatuses for navigating the subarachnoid space
US6811551B2 (en) Method for reducing myocardial infarct by application of intravascular hypothermia
US20010032003A1 (en) Over the wire heat exchange catheter with distal valve
US6685733B1 (en) Methods and systems for reducing substance-induced renal damage
EP2255725A1 (en) Central venous catheter with heat exchange properties
US6419690B1 (en) Urethral warming catheter
US6096068A (en) Selective organ cooling catheter and method of using the same
US7922752B2 (en) Method of making selective organ cooling catheter
US20020007203A1 (en) Method of manufacturing a heat transfer element for in vivo cooling
US6238428B1 (en) Selective organ cooling apparatus and method employing turbulence-inducing element with curved terminations
CA2318084C (en) Selective organ hypothermia method and apparatus
US20050021113A1 (en) System and method using the rectal mucosal membrane for inducing hypothermia and warming
EP1589915B1 (en) Intravascular temperature control catheter
US6733517B1 (en) Angling introducer sheath for catheter having temperature control system
US6042559A (en) Insulated catheter for selective organ perfusion
US7063718B2 (en) Selective organ hypothermia method and apparatus
US6582398B1 (en) Method of managing patient temperature with a heat exchange catheter
US6224624B1 (en) Selective organ cooling apparatus and method
DE69911434T2 (en) Heat exchanging permanent catheter
US6551349B2 (en) Selective organ cooling apparatus

Legal Events

Date Code Title Description
AS Assignment

Owner name: ALSIUS CORPORATION, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GOBIN, YVES PIERRE;EVANS, SCOTT M.;JONES, MIKE L.;AND OTHERS;REEL/FRAME:013003/0184;SIGNING DATES FROM 20020425 TO 20020530

Owner name: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CALIF

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:GOBIN, YVES PIERRE;EVANS, SCOTT M.;JONES, MIKE L.;AND OTHERS;REEL/FRAME:013003/0184;SIGNING DATES FROM 20020425 TO 20020530

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION