Connect public, paid and private patent data with Google Patents Public Datasets

Heat exchange catheter having a helically wrapped heat exchanger

Download PDF

Info

Publication number
US20020116039A1
US20020116039A1 US09791391 US79139101A US2002116039A1 US 20020116039 A1 US20020116039 A1 US 20020116039A1 US 09791391 US09791391 US 09791391 US 79139101 A US79139101 A US 79139101A US 2002116039 A1 US2002116039 A1 US 2002116039A1
Authority
US
Grant status
Application
Patent type
Prior art keywords
heat
exchange
catheter
fluid
lumen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
US09791391
Other versions
US6451045B1 (en )
Inventor
Blair Walker
Nora Pham
Xochitl Huezo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zoll Circulation Inc
Original Assignee
Alsius Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F2007/126Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F7/123Devices for heating or cooling internal body cavities using a flexible balloon containing the thermal element

Abstract

A heat exchange catheter has a catheter body with an inflow lumen, an outflow lumen, and an infusion lumen. A first heat exchange balloon helically wraps around at least a portion of the catheter body in fluid communication with the inflow lumen. A second heat exchange balloon helically wraps around at least a portion of the catheter body in fluid communication with the outflow lumen. The first and second balloons form a gap there between to facilitate infusion of fluid into the blood stream of the patient via an infusion port formed within the gap.

Description

    FIELD OF THE INVENTION
  • [0001]
    This invention relates to heat exchange catheters, and particularly to catheters that exchange heat with the blood stream of a patient.
  • BACKGROUND
  • [0002]
    Heat exchange catheters are used in many instances for a variety of reasons. Some surgeries, for example, are better performed when the patient cools to a hypothermic state. In other instances, a patient may suffer from accidental hypothermia and may need to be warmed to a normothermic temperature e.g. 98.6° F. Some heat exchange catheters include the capability of infusing fluids such as nutrition, medicine and contrast agents into the blood.
  • [0003]
    Post surgical patients risk infection and fever. A fever can be controlled through the use of a heat exchange system having an intravascular heat exchange catheter. One such system is disclosed in U.S. Pat. No. 6,146,411. This U.S. Patent is incorporated herein by reference and teaches an exemplary system used to achieve patient normothermia.
  • [0004]
    The principals of heat exchange applicable to any flowing medium (including blood) dictates the amount of heat transfer. In blood, the heat transferred depends on many things including the volumetric flow rate of the blood, the geometry of the heat exchanger and the temperature difference between the heat exchanger and the blood.
  • [0005]
    Various heat exchange catheter designs have been developed. U.S. Pat. No. 6,126,684, for example, teaches a heat exchange catheter having tubular balloons in serial alignment to exchange heat with the blood stream of a patient. This U.S. Patent is incorporated herein by reference. The balloons allow for a relatively large surface area of contact for heat exchange. Infusion lumen exit ports are defined between the balloons. Unfortunately, these exit port regions limit the effective heat exchange surface area.
  • [0006]
    Heat exchange catheter balloons can be sized having an external volume that optimally exchanges heat with the flowing blood. The balloon internal volume, however, is large enough to inhibit optimal mixing of the heat exchange fluid. Boundary layers of heat exchange fluid can form in the interior of such balloons, lowering the temperature gradient between the heat exchange fluid at the balloon internal surface and ultimately reducing the effective rate of heat transfer between the heat transfer fluid and the flowing blood.
  • [0007]
    Heat exchange catheters have been developed that deliver the heat exchange fluid to the distal end of the catheter via an insulated delivery lumen, causing the heat exchange fluid to maintain a relatively uniform temperature until the heat exchange fluid returns via a return lumen to exchange heat with the flowing blood. This improves the temperature gradient between the heat exchange fluid within the interior balloon walls and the flowing blood, unfortunately, the residence time that the heat exchange fluid interacts with the flowing blood is limited.
  • [0008]
    Blood has a maximum desirable heating limit because above certain temperatures blood proteins can degenerate and coagulation may occurr. This limits the maximum operating temperature of known intravasculature catheters. Because the operating temperature of an intravascular catheter is limited, the catheter geometry takes on an increased importance to effectuate overall heat transfer.
  • [0009]
    What is desired is a heat exchange catheter having a geometry that is optimally designed for transferring heat to flowing blood.
  • SUMMARY
  • [0010]
    A heat exchange catheter includes a catheter body having an inflow lumen, an outflow lumen, a proximal region and a distal region. A first balloon helically wraps around at least a portion of the catheter body and maintains fluid communication with the inflow lumen. A second balloon helically wraps around at least a portion of the catheter body and maintains in fluid communication with the outflow lumen. The first and second balloons forming a fluid circuit to facilitate circulation of a heat exchange fluid through the first balloon and the second balloon.
  • [0011]
    Optimally, the first and second balloons are inflatable from a flattened configuration where the balloons lie flush with the catheter body to an operational configuration where the heat exchange fluid inflates the balloons. The flattened configuration facilitates insertion of the catheter into the body of a patient. Preferably, the catheter inserts into the central vasculature.
  • [0012]
    The catheter body defines a core extending between the proximal region and the distal region. The inflow lumen and the outflow lumen being defined within the core in the proximal region. The balloons further define the inflow and outflow lumens in the distal region. The core also defines a guidewire lumen.
  • [0013]
    The first balloon and second balloon wrap around the distal region. According to one aspect of the invention, the balloons define a gap there between. According to an alternate aspect of the invention, the balloons tightly wrap and forms a gap only to expose an exit port. Both of these aspects of the invention include the catheter body defining at least one infusion lumen having an exit port located in the gap.
  • [0014]
    According to one aspect of the invention, the first balloon and second balloon wrap tightly around the distal region of the core without a gap between the first and second balloon.
  • [0015]
    According to another aspect of the invention, a sheath surrounds the first and second balloons to inhibit coagulate formation. The sheath is distanced from the first and second balloons according to a variation of the invention. The sheath contacts the first and second balloons according to an alternate variation of the invention.
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • [0016]
    [0016]FIG. 1 shows a heat exchange catheter in accordance with the present invention.
  • [0017]
    [0017]FIG. 2A shows a cross-section of the catheter as seen along line A-A of FIG. 1
  • [0018]
    [0018]FIG. 2B shows a cross-section of the catheter as seen along line B-B of FIG. 1.
  • [0019]
    [0019]FIG. 2C shows a cross-section of the catheter as seen along line C-C of FIG. 1.
  • [0020]
    [0020]FIG. 3 shows a partial longitudinal-section of the distal region per FIG. 1.
  • [0021]
    [0021]FIG. 4 shows an embodiment of the distal region in accordance with the invention.
  • [0022]
    [0022]FIG. 5 shows an embodiment of the distal region in accordance with the invention.
  • [0023]
    [0023]FIG. 6 shows an embodiment of the distal region in accordance with the invention.
  • DETAILED DESCRIPTION
  • [0024]
    [0024]FIG. 1 shows a heat exchange catheter, generally designated with the reference numeral 10. The catheter 10 includes a catheter body 12 having an inflow lumen 14, an outflow lumen 16, a proximal region 18, a distal region 20, and a distal tip 22. The catheter 10 also includes a first balloon 24 helically wrapping around the distal region 20 of the catheter body 12 and being in fluid communication with the inflow lumen 14. The catheter 10 further includes a second balloon 26 helically wrapping around the distal region 20 of the catheter body 12 and being in fluid communication with the outflow lumen 16. The first balloon 24 and the second balloon 26 connect in fluid communication in the tip 22 of the catheter body 12 to form a fluid circuit.
  • [0025]
    The catheter 10 includes an infusion lumen 30 and an infusion lumen 32, which terminate at infusion port 34 and infusion port 36, respectively. The first balloon 24 and the second balloon 26 wrap in a helical pattern to form a helical gap there between. Infusion port 34 and infusion port 36 are located in the helical gap. The infusion lumens 30 and 32 facilitate infusion of fluids such as nutrients, medicines, contrast agents and the like through the infusion ports 34 and 36. According to one aspect of the invention, the catheter 10 defines a centrally located guidewire lumen that also functions to facilitate infusion of fluids.
  • [0026]
    A heat exchange fluid is pumped via the inflow lumen 14 into the first balloon 24. The heat exchange fluid reaches the tip 22 of the catheter body 12. From the tip 22, the heat exchange fluid returns via the second balloon 26 and the outflow lumen 16. The temperature, pressure, and flow rate of the heat exchange fluid is regulated externally. It can be appreciated, however, that the catheter 10 can be equipped with sensors and supplemental heating/cooling elements to further monitor and regulate the temperature, pressure and flow rate of the heat exchange fluid. Optimally, the catheter 10 is designed for intravascular use. It is conceivable, however, that the catheter 10 can be used in various internal regions of the body.
  • [0027]
    The catheter body 12 defines a core 27 extending between the proximal region 18 and the distal region 20. The inflow lumen 14 and the outflow lumen 16 are defined within the core, in the proximal region 18.
  • [0028]
    [0028]FIG. 2A shows a cross-section of the proximal region 18 of the catheter body 12. The proximal region 18 defines a guidewire lumen 28, two infusion lumens 30 and 32. The inflow lumen 14 and the outflow lumen 16 are defined within the catheter body 12.
  • [0029]
    [0029]FIG. 2B shows a cross-section of the distal region 20 of the catheter body 12. The balloons 24 and 26 are inflatable from a flattened configuration where the balloons lie flush with the catheter body to an operational configuration. As shown, the balloons 24 and 26 are filled with heat exchange fluid 38, which inflates the balloons 24 and 26 during operation of the heat exchange catheter 10.
  • [0030]
    [0030]FIG. 2C shows a cross-section of the distal tip 22 of the catheter body 12. The distal tip 22 includes the guidewire lumen 28 and a transition region 40. The transition region 40 joins the inflow lumen and the outflow lumen in fluid communication.
  • [0031]
    [0031]FIG. 3 shows a portion of the distal region 20. The balloon 24 carries the heat exchange fluid in the direction of the arrow 42, towards the distal tip 22. The balloon 26 carries heat exchange fluid in the direction of the arrow 44, away from the distal tip 22. The balloon 24 and the balloon 26 define a gap 46 there between. The gap 46 extends along a helical path between the balloons 24 and 26. The infusion ports 34 and 36 are formed on the distal region 20, within the gap 46.
  • [0032]
    The gap 46 distances the balloons 24 and 26 to maximize the surface area of the balloons 24 and 26 for heat transfer. Typically blood from a patient's blood stream would flow by the balloons 24 and 26 to heat or cool the patient's body. The gap 46 also enables positioning of the infusion ports 34 and 36 at any desired location along the proximal region 20. According to one aspect of the invention, the guidewire lumen 28 functions to infuse fluids through the distal tip 22.
  • [0033]
    [0033]FIG. 4 shows a sheath 50 surrounding the balloon 24. The sheath 50 prevents coagulum from forming within the gap 46. The sheath 50 is distanced from the balloon 24 in a radial direction from the distal region 20 according to one aspect of the invention. According to an alternate aspect of the invention, the sheath 50 contacts the balloon 24. According to a further aspect of the invention, an infusion port or ports can be formed within the gap 46.
  • [0034]
    [0034]FIG. 5 shows a single balloon 26 on the distal region 20. The balloon 26 has ends 60 and 62 and is helically wrapped to form a gap 46 between successive coils. The gap 46 extends along a helical path between the ends 60 and 62. Infusion ports 34 and 36 are positioned near each end 60 and 62 of the balloon 26, and within the gap 46.
  • [0035]
    [0035]FIG. 6 shows a single balloon 36 on the distal region 20. The balloon 36 wraps tightly around the distal region 20, maintaining contact with itself without forming a helical gap. It can be appreciated that when an infusion port formed on the catheter 10 requires exposure, the balloon 36 is conformed with a small gap to expose the infusion port.
  • In Operation
  • [0036]
    A method of circulating fluid within a heat exchange catheter includes inserting the heat exchange catheter into the central vasculature of a patient. The proximal portion of the catheter is secured to the patient to prevent catheter movement.
  • [0037]
    The next step includes circulating a heat exchange fluid through the inflow lumen of a heat exchange catheter. The heat exchange fluid circulates along a helical path to exchange heat with the blood stream of a patient. One benefit of circulating the heat exchange fluid along a helical path is that the residence time that the heat exchange fluid transfers heat is increased compared with tubular heat exchanger systems.
  • [0038]
    Another benefit circulating the heat exchange fluid along a helical path is that the helical path causes fluid mixing within the catheter. This mixing causes vortices, which disrupts the heat exchange fluid at the boundary layer located at the wall of the inflow and out flow lumens. Further, the helical shape causes blood to flow, turbulently under some conditions, past the heat exchange catheter to improve heat transfer between the heat exchange catheter and the blood.
  • [0039]
    To add medicine, nutrition, contrast agents and the like, the step of infusing fluid into the blood stream via the heat exchange catheter is performed.
  • [0040]
    According to one aspect of the invention, the heat exchange occurs through dual helical balloons. One helical balloon circulates fluid from the inflow lumen, the other circulates fluid through the outflow lumen along a helical path. The heat exchange fluid inflates both balloons from a flattened configuration to an operational configuration. Preferably, the operational configuration includes inflating the balloons to a round or an oval cross-sectional configuration.
  • [0041]
    It can be appreciated that the core of the catheter can inflow heat exchange fluid to the distally mounted heat exchange balloon(s). Alternatively, the balloon(s) can inflow the heat exchange fluid and the core can outflow the heat exchange fluid. Optimally, however, the present invention includes two helical balloons, one inflows heat exchange fluid and the other outflows the heat exchange fluid. Many variations of this concept are possible. Accordingly, the present invention should be limited only by the following claims.

Claims (28)

1. A heat exchange catheter, comprising:
a catheter body having an inflow lumen, an outflow lumen, a proximal region and a distal region;
a first balloon helically wrapping around at least a portion of the catheter body and being in fluid communication with the inflow lumen;
a second balloon helically wrapping around at least a portion of the catheter body and being in fluid communication with the outflow lumen; and
the first and second balloons forming a fluid circuit to facilitate circulation of a heat exchange fluid through the first balloon and the second balloon.
2. A heat exchange catheter as set forth in claim 1, wherein the first balloon and second balloon wrap around the distal region, the first balloon and the second balloon define a gap, and the catheter body defines at least one infusion lumen having an exit port located in the gap between the balloons.
3. A heat exchange catheter as set forth in claim 1, wherein the first and second balloons are inflatable from a flattened configuration where the balloons lie flush with the catheter body to an operational configuration where the heat exchange fluid inflates the balloons.
4. A heat exchange catheter as set forth in claim 2, wherein the proximal region defines a portion of the inflow lumen and the outflow lumen.
5. A heat exchange catheter as set forth in claim 1, wherein the catheter body defines a guidewire lumen.
6. A heat exchange catheter as set forth in claim 1, wherein the inflow lumen and the outflow lumen are defined within the proximal region, the first balloon and second balloon wrap tightly around the distal region.
7. A heat exchange catheter as set forth in claim 1, further comprising a sheath surrounding the first and second balloons.
8. A heat exchange catheter as set forth in claim 7, wherein the sheath is distanced from the first and second balloons.
9. A heat exchange catheter as set forth in claim 7, wherein the sheath contacts the first and second balloons.
10. A heat exchange catheter as set forth in claim 1, wherein the catheter body includes a transition region that interconnects the inflow lumen and the outflow lumen in fluid communication.
11. A heat exchange catheter as set forth in claim 1, wherein the catheter body includes a distal tip with a transition region that interconnects the inflow lumen and the outflow lumen in fluid communication.
12. A heat exchange catheter, comprising:
a catheter's body having an inflow lumen, an outflow lumen, a proximal end and a distal end;
a first balloon helically wrapping around at least a portion of the catheter body and being in fluid communication with the inflow lumen;
a second balloon helically wrapping around at least a portion of the catheter body and being in fluid communication with the outflow lumen;
the first and second balloons forming a fluid circuit to facilitate circulation of heat exchange fluid through the first and second balloons; and
a sheath surrounding the first and second balloons.
13. A heat exchange catheter as set forth in claim 12, wherein the distal end includes a transition region that connects the inflow lumen and the outflow lumen in fluid communication.
14. A heat exchange catheter as set forth in claim 12, wherein the catheter body defines an infusion lumen.
15. A heat exchange catheter as set forth in claim 14, wherein the first and second balloons define a gap, an infusion port in communication with the infusion lumen is formed within the gap.
16. A method of circulating fluid within a heat exchange catheter, comprising: circulating heat exchange fluid through a heat exchange catheter along a helical path to exchange heat with the blood stream of a patient; and infusing fluid into the blood stream via the heat exchange catheter.
17. A method of circulating fluid within a heat exchange catheter as set forth in claim 16, further comprising circulating the heat exchange fluid through an inflow lumen along a helical path and through an outflow lumen along a helical path.
18. A method of circulating fluid within a heat exchange catheter as set forth in claim 17, further comprising inflating a first and second heat exchange balloon with the heat exchange fluid.
19. A method of circulating fluid within a heat exchange catheter as set forth in claim 18, wherein the first and second balloons form helical a gap there between.
20. A method of circulating fluid within a heat exchange catheter as set forth in claim 19, wherein the infusing fluid is accomplished by infusing fluid through an infusion port defined within the gap.
21. A heat exchange catheter, comprising:
a catheter body having an inflow lumen, an outflow lumen, a proximal region and a distal region;
a first heat exchange means helically wrapping around at least a portion of the catheter body and being in fluid communication with the inflow lumen;
a second heat exchange means helically wrapping around at least a portion of the catheter body and being in fluid communication with the outflow lumen; and the first heat exchange means and second heat exchange means forming a fluid circuit to facilitate circulation of a heat exchange fluid through the first heat exchange means and the second heat exchange means.
22. A heat exchange catheter as set forth in claim 21, wherein the first heat exchange means and second heat exchange means wrap around the distal region, the first heat exchange means and the second heat exchange means define a gap, and the catheter body defines at least one infusion lumen having an exit port located in the gap between the heat exchange means.
23. A heat exchange catheter as set forth in claim 21, wherein the first heat exchange means and the second heat exchange means are inflatable from a flattened configuration to an operational configuration.
24. A heat exchange catheter as set forth in claim 22, wherein the proximal region defines a portion of the inflow lumen and the outflow lumen.
25. A heat exchange catheter as set forth in claim 21, wherein the catheter body defines a guidewire lumen.
26. A heat exchange catheter as set forth in claim 1, wherein the inflow lumen and the outflow lumen are defined within the proximal region, the first heat exchange means and second heat exchange means wrap tightly around the distal region.
27. A heat exchange catheter as set forth in claim 21, further comprising a sheath surrounding the first heat exchange means and the second heat exchange means.
28. A heat exchange catheter as set forth in claim 27, wherein the sheath is distanced from the first heat exchange means and the second heat exchange means.
US09791391 2001-02-22 2001-02-22 Heat exchange catheter having a helically wrapped heat exchanger Active 2021-04-02 US6451045B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US09791391 US6451045B1 (en) 2001-02-22 2001-02-22 Heat exchange catheter having a helically wrapped heat exchanger

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09791391 US6451045B1 (en) 2001-02-22 2001-02-22 Heat exchange catheter having a helically wrapped heat exchanger
US10205066 US20030040782A1 (en) 2001-02-22 2002-07-25 Heat exchange catheter having a helically wrapped heat exchanger

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10205066 Continuation US20030040782A1 (en) 2001-02-22 2002-07-25 Heat exchange catheter having a helically wrapped heat exchanger

Publications (2)

Publication Number Publication Date
US20020116039A1 true true US20020116039A1 (en) 2002-08-22
US6451045B1 US6451045B1 (en) 2002-09-17

Family

ID=25153590

Family Applications (2)

Application Number Title Priority Date Filing Date
US09791391 Active 2021-04-02 US6451045B1 (en) 2001-02-22 2001-02-22 Heat exchange catheter having a helically wrapped heat exchanger
US10205066 Abandoned US20030040782A1 (en) 2001-02-22 2002-07-25 Heat exchange catheter having a helically wrapped heat exchanger

Family Applications After (1)

Application Number Title Priority Date Filing Date
US10205066 Abandoned US20030040782A1 (en) 2001-02-22 2002-07-25 Heat exchange catheter having a helically wrapped heat exchanger

Country Status (1)

Country Link
US (2) US6451045B1 (en)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
US20040210285A1 (en) * 2002-04-04 2004-10-21 Steven Yon Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US20050010272A1 (en) * 2002-08-30 2005-01-13 Alsius Corporation Intravascular temperature control catheter
EP2146772A1 (en) * 2007-05-18 2010-01-27 ZOLL Circulation, Inc. System and method for effecting non-standard fluid line connections
US7998182B2 (en) 1998-01-23 2011-08-16 Innercool Therapies, Inc. Selective organ cooling apparatus
WO2013048815A1 (en) * 2011-09-28 2013-04-04 Zoll Circulation, Inc. Patient temperature control catheter with helical heat exchange paths
US20130090593A1 (en) * 2011-09-30 2013-04-11 Zoll Circulation, Inc. Heat Exchange Catheter and Their Methods of Manufacture and Use
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US8672988B2 (en) 2004-10-22 2014-03-18 Medtronic Cryocath Lp Method and device for local cooling within an organ using an intravascular device
JP2014528282A (en) * 2011-09-30 2014-10-27 ゾール サーキュレイション インコーポレイテッドZOLL Circulation,Inc. Heat exchange catheter having a bidirectional fluid flow, as well as methods of making and using the Part
JP2014531991A (en) * 2011-09-01 2014-12-04 コヴィディエン リミテッド パートナーシップ Catheters and manufacturing method having a helical drive shaft
CN105228542A (en) * 2013-03-13 2016-01-06 康沣生物科技(上海)有限公司 Therapeutic cryoablation system

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6702841B2 (en) 1998-01-23 2004-03-09 Innercool Therapies, Inc. Method of manufacturing a heat transfer element for in vivo cooling
US7371254B2 (en) * 1998-01-23 2008-05-13 Innercool Therapies, Inc. Medical procedure
US6051019A (en) 1998-01-23 2000-04-18 Del Mar Medical Technologies, Inc. Selective organ hypothermia method and apparatus
US6261312B1 (en) * 1998-06-23 2001-07-17 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US6338727B1 (en) 1998-08-13 2002-01-15 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6702811B2 (en) 1999-04-05 2004-03-09 Medtronic, Inc. Ablation catheter assembly with radially decreasing helix and method of use
US6450987B1 (en) 2001-02-01 2002-09-17 Innercool Therapies, Inc. Collapsible guidewire lumen
US6752786B2 (en) * 2001-05-31 2004-06-22 Radiant Medical, Inc. Moving heat exchange catheter system
US7653438B2 (en) 2002-04-08 2010-01-26 Ardian, Inc. Methods and apparatus for renal neuromodulation
US20140018880A1 (en) 2002-04-08 2014-01-16 Medtronic Ardian Luxembourg S.A.R.L. Methods for monopolar renal neuromodulation
US8774913B2 (en) 2002-04-08 2014-07-08 Medtronic Ardian Luxembourg S.A.R.L. Methods and apparatus for intravasculary-induced neuromodulation
US7179279B2 (en) * 2002-09-30 2007-02-20 Medtronic Physio Control Corp. Rapid induction of mild hypothermia
US20040199114A1 (en) * 2003-04-01 2004-10-07 Alsius Corporation Intravascular heat exchange catheter with tissue preservative
US6893454B2 (en) * 2003-04-28 2005-05-17 Alsius Corporation Intrarectal heat exchange catheter
US7306623B2 (en) * 2005-01-13 2007-12-11 Medtronic Vascular, Inc. Branch vessel graft design and deployment method
US20060190066A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for bringing hypothermia rapidly onboard
US7892269B2 (en) 2005-04-18 2011-02-22 Zoll Circulation, Inc. External heat exchange pad for patient
US7425216B2 (en) 2005-03-01 2008-09-16 Alsius Corporation System and method for treating cardiac arrest and myocardial infarction
US7181927B2 (en) 2005-07-01 2007-02-27 Alsius Corporation Primary heat exchanger for patient temperature control
US7951182B2 (en) 2005-07-14 2011-05-31 Zoll Circulation, Inc. System and method for leak detection in external cooling pad
US20070093697A1 (en) 2005-10-21 2007-04-26 Theranova, Llc Method and apparatus for detection of right to left shunting in the cardiopulmonary vasculature
WO2007115174A3 (en) * 2006-03-31 2008-02-21 Traxtal Inc System, methods, and instrumentation for image guided prostate treatment
US7822485B2 (en) 2006-09-25 2010-10-26 Zoll Circulation, Inc. Method and apparatus for spinal cooling
US7867266B2 (en) 2006-11-13 2011-01-11 Zoll Circulation, Inc. Temperature management system with assist mode for use with heart-lung machine
US7892270B2 (en) 2006-11-21 2011-02-22 Zoll Circulation Inc. Temperature management system and method for burn patients
US8353893B2 (en) 2007-03-07 2013-01-15 Zoll Circulation, Inc. System and method for rapidly cooling cardiac arrest patient
WO2008124644A1 (en) 2007-04-05 2008-10-16 Velomedix, Inc Automated therapy system and method
CA2693774A1 (en) 2007-07-09 2009-01-15 Velomedix, Inc. Hypothermia devices and methods
US9622670B2 (en) 2010-07-09 2017-04-18 Potrero Medical, Inc. Method and apparatus for pressure measurement
WO2012061161A1 (en) 2010-10-25 2012-05-10 Medtronic Ardian Luxembourg S.A.R.L. Catheter apparatuses having multi-electrode arrays for renal neuromodulation and associated systems and methods
US9060754B2 (en) 2010-10-26 2015-06-23 Medtronic Ardian Luxembourg S.A.R.L. Neuromodulation cryotherapeutic devices and associated systems and methods
US20120143294A1 (en) 2010-10-26 2012-06-07 Medtronic Adrian Luxembourg S.a.r.l. Neuromodulation cryotherapeutic devices and associated systems and methods
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
EP3181081A1 (en) 2012-05-11 2017-06-21 Medtronic Ardian Luxembourg S.à.r.l. Multi-electrode catheter assemblies for renal neuromodulation and associated systems
US9433528B2 (en) * 2012-09-28 2016-09-06 Zoll Circulation, Inc. Intravascular heat exchange catheter with rib cage-like coolant path
US9095321B2 (en) 2012-11-21 2015-08-04 Medtronic Ardian Luxembourg S.A.R.L. Cryotherapeutic devices having integral multi-helical balloons and methods of making the same
US9017317B2 (en) 2012-12-06 2015-04-28 Medtronic Ardian Luxembourg S.A.R.L. Refrigerant supply system for cryotherapy including refrigerant recompression and associated devices, systems, and methods
US9179974B2 (en) 2013-03-15 2015-11-10 Medtronic Ardian Luxembourg S.A.R.L. Helical push wire electrode
WO2017019730A1 (en) * 2015-07-27 2017-02-02 University Of Maryland, Baltimore Body temperature management devices and methods

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3328321A (en) * 1966-01-27 1967-06-27 Wismer Marco Cellular polyurethanes prepared from polyhydroxy resinous reaction products of an amino-s-triazine and an alkylene carbonate or an alkylene oxide
US4356304A (en) * 1980-11-10 1982-10-26 American Cyanamid Company Synthesis of oxyalkylated polyamino-1,3,5-triazines
DE3214397C2 (en) 1982-04-20 1984-07-26 Karl Dr. 6301 Pohlheim De Aigner
US4546759A (en) 1983-07-29 1985-10-15 Mladen Solar Method and apparatus for assisting human heart function
CA1301007C (en) 1989-01-30 1992-05-19 Geoffrey S. Martin Angioplasty catheter with spiral balloon
US5549559A (en) 1990-03-22 1996-08-27 Argomed Ltd. Thermal treatment apparatus
US5624392A (en) * 1990-05-11 1997-04-29 Saab; Mark A. Heat transfer catheters and methods of making and using same
US5153245A (en) * 1990-09-11 1992-10-06 Ministero Dell'universita' E Della Ricerca Scientifica E Technologic Self-extinguishing polymeric compositions
US5308320A (en) 1990-12-28 1994-05-03 University Of Pittsburgh Of The Commonwealth System Of Higher Education Portable and modular cardiopulmonary bypass apparatus and associated aortic balloon catheter and associated method
US5207640A (en) 1991-03-27 1993-05-04 Hattler Brack G Method of anesthetizing a patient
US5271743A (en) 1991-03-27 1993-12-21 Hattler Brack G System to optimize the transfer of gas through membranes
US5211631A (en) 1991-07-24 1993-05-18 Sheaff Charles M Patient warming apparatus
US5304214A (en) 1992-01-21 1994-04-19 Med Institute, Inc. Transurethral ablation catheter
US5342301A (en) 1992-08-13 1994-08-30 Advanced Polymers Incorporated Multi-lumen balloons and catheters made therewith
US6110168A (en) * 1993-02-10 2000-08-29 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modifications
US5383856A (en) * 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5501663A (en) 1993-07-02 1996-03-26 Medtronic Electromedics, Inc. Inflatable percutaneous oxygenator with transverse hollow fibers
US5464437A (en) 1993-07-08 1995-11-07 Urologix, Inc. Benign prostatic hyperplasia treatment catheter with urethral cooling
US5478309A (en) 1994-05-27 1995-12-26 William P. Sweezer, Jr. Catheter system and method for providing cardiopulmonary bypass pump support during heart surgery
US5749852A (en) 1996-07-23 1998-05-12 Medtronic, Inc. Sheath system for autoperfusion dilatation catheter balloon
US5735816A (en) 1996-07-23 1998-04-07 Medtronic, Inc. Spiral sheath retainer for autoperfusion dilatation catheter balloon
US5797948A (en) 1996-10-03 1998-08-25 Cordis Corporation Centering balloon catheter
US6033383A (en) * 1996-12-19 2000-03-07 Ginsburg; Robert Temperature regulating catheter and methods
US5891386A (en) 1997-04-25 1999-04-06 Medtronic, Inc. Method for making catheter balloons
US6190356B1 (en) * 1997-10-20 2001-02-20 Robert M. Bersin Helical spiral balloon catheter
US6051019A (en) 1998-01-23 2000-04-18 Del Mar Medical Technologies, Inc. Selective organ hypothermia method and apparatus
US6261312B1 (en) * 1998-06-23 2001-07-17 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6126684A (en) * 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6610083B2 (en) * 1998-08-24 2003-08-26 Radiant Medical, Inc. Multiple lumen heat exchange catheters
US6299599B1 (en) * 1999-02-19 2001-10-09 Alsius Corporation Dual balloon central venous line catheter temperature control system
US6287326B1 (en) 1999-08-02 2001-09-11 Alsius Corporation Catheter with coiled multi-lumen heat transfer extension
US6231594B1 (en) * 1999-08-11 2001-05-15 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering
US6264679B1 (en) * 1999-08-20 2001-07-24 Radiant Medical, Inc. Heat exchange catheter with discrete heat exchange elements
US6428563B1 (en) * 2000-01-21 2002-08-06 Radiant Medical, Inc. Heat exchange catheter with improved insulated region
US6582457B2 (en) * 2001-02-15 2003-06-24 Radiant Medical, Inc. Method of controlling body temperature while reducing shivering

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7766949B2 (en) 1998-01-23 2010-08-03 Innercool Therapies, Inc. Fever regulation method and apparatus
US7998182B2 (en) 1998-01-23 2011-08-16 Innercool Therapies, Inc. Selective organ cooling apparatus
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
US8172889B2 (en) 2002-04-04 2012-05-08 Innercoll Therapies, Inc. Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US7288109B2 (en) 2002-04-04 2007-10-30 Innercool Therapies. Inc. Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US20040210285A1 (en) * 2002-04-04 2004-10-21 Steven Yon Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US20050010272A1 (en) * 2002-08-30 2005-01-13 Alsius Corporation Intravascular temperature control catheter
JP2007501689A (en) * 2003-01-31 2007-02-01 オルシウス・コーポレイションAlsius Corporation Intravascular temperature control catheter
EP2174625A1 (en) * 2003-01-31 2010-04-14 ZOLL Circulation, Inc. Intravascular temperature control catheter
EP1589915A2 (en) * 2003-01-31 2005-11-02 Alsius Corporation Intravascular temperature control catheter
EP1589915A4 (en) * 2003-01-31 2006-08-16 Alsius Corp Intravascular temperature control catheter
US8672988B2 (en) 2004-10-22 2014-03-18 Medtronic Cryocath Lp Method and device for local cooling within an organ using an intravascular device
EP2146772A4 (en) * 2007-05-18 2012-07-04 Zoll Circulation Inc System and method for effecting non-standard fluid line connections
EP2474337A1 (en) * 2007-05-18 2012-07-11 ZOLL Circulation, Inc. Connector system for effecting non-standard fluid line connections
US9737692B2 (en) 2007-05-18 2017-08-22 Zoll Circulation, Inc. System and method for effecting non-standard fluid line connections
EP2146772A1 (en) * 2007-05-18 2010-01-27 ZOLL Circulation, Inc. System and method for effecting non-standard fluid line connections
US8608696B1 (en) 2009-02-24 2013-12-17 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
US8808241B2 (en) 2009-02-24 2014-08-19 North Carolina State University Rapid fluid cooling devices and methods for cooling fluids
JP2014531991A (en) * 2011-09-01 2014-12-04 コヴィディエン リミテッド パートナーシップ Catheters and manufacturing method having a helical drive shaft
US8992717B2 (en) 2011-09-01 2015-03-31 Covidien Lp Catheter with helical drive shaft and methods of manufacture
US9770259B2 (en) 2011-09-01 2017-09-26 Covidien Lp Catheter with helical drive shaft and methods of manufacture
WO2013048815A1 (en) * 2011-09-28 2013-04-04 Zoll Circulation, Inc. Patient temperature control catheter with helical heat exchange paths
JP2014528282A (en) * 2011-09-30 2014-10-27 ゾール サーキュレイション インコーポレイテッドZOLL Circulation,Inc. Heat exchange catheter having a bidirectional fluid flow, as well as methods of making and using the Part
EP2760395A4 (en) * 2011-09-30 2015-06-24 Zoll Circulation Inc Heat exchange catheters with bi-directional fluid flow and their methods of manufacture and use
US20130090593A1 (en) * 2011-09-30 2013-04-11 Zoll Circulation, Inc. Heat Exchange Catheter and Their Methods of Manufacture and Use
US9492633B2 (en) * 2011-09-30 2016-11-15 Zoll Circulation, Inc. Heat exchange catheter and their methods of manufacture and use
US9662243B2 (en) 2011-09-30 2017-05-30 Zoll Circulation, Inc. Heat exchange catheters with bi-directional fluid flow and their methods of manufacture and use
EP3195835A1 (en) * 2011-09-30 2017-07-26 Zoll Circulation, Inc. Heat exchange catheter
EP2760394A4 (en) * 2011-09-30 2015-06-24 Zoll Circulation Inc Heat exchange catheters and their methods of manufacture and use
EP2967709A4 (en) * 2013-03-13 2016-11-09 Cryofocus Medtech Shanghai Co Ltd Therapeutic cryoablation system
CN105228542A (en) * 2013-03-13 2016-01-06 康沣生物科技(上海)有限公司 Therapeutic cryoablation system

Also Published As

Publication number Publication date Type
US20030040782A1 (en) 2003-02-27 application
US6451045B1 (en) 2002-09-17 grant

Similar Documents

Publication Publication Date Title
US6299599B1 (en) Dual balloon central venous line catheter temperature control system
US6251129B1 (en) Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control
US6245095B1 (en) Method and apparatus for location and temperature specific drug action such as thrombolysis
US6974463B2 (en) System and method for patient temperature control employing temperature projection algorithm
US6254626B1 (en) Articulation device for selective organ cooling apparatus
US6702839B1 (en) Method of controlling body temperature while reducing shivering
US6224624B1 (en) Selective organ cooling apparatus and method
US6042559A (en) Insulated catheter for selective organ perfusion
US6648908B2 (en) Inflatable catheter for selective organ heating and cooling and method of using the same
US6749625B2 (en) Intravascular temperature control catheter
US6582457B2 (en) Method of controlling body temperature while reducing shivering
US6464716B1 (en) Selective organ cooling apparatus and method
US6551349B2 (en) Selective organ cooling apparatus
US6740109B2 (en) Isolated selective organ cooling method
US6733517B1 (en) Angling introducer sheath for catheter having temperature control system
US6379378B1 (en) Lumen design for catheter
US20010002442A1 (en) Isolated selective organ cooling method and apparatus
US6520933B1 (en) Central venous line cooling catheter having a spiral-shaped heat exchange member
US6607517B1 (en) Method of inotropic treatment of heart disease using hypothermia
US6582455B1 (en) Method and device for applications of selective organ cooling
US6685733B1 (en) Methods and systems for reducing substance-induced renal damage
US20030060863A1 (en) Method and apparatus for patient temperature control employing administration of anti-shivering agents
US6648906B2 (en) Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid
US6676690B2 (en) Inflatable heat transfer apparatus
US7144407B1 (en) Cardiovascular intra aortic balloon pump catheter with heat exchange function and methods of use

Legal Events

Date Code Title Description
AS Assignment

Owner name: ALSIUS CORPORATION, CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:WALKER, BLAIR;PHAM, NORA TRAN;HUEZO, XOCHITL;REEL/FRAME:011735/0697;SIGNING DATES FROM 20010410 TO 20010413

FPAY Fee payment

Year of fee payment: 4

AS Assignment

Owner name: ZOLL CIRCULATION, INC., CALIFORNIA

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ALSIUS CORPORATION;ALSIUS MEDICAL CORPORATION;REEL/FRAME:023163/0419

Effective date: 20090504

FPAY Fee payment

Year of fee payment: 8

FPAY Fee payment

Year of fee payment: 12