US20020068964A1 - Heat pipe nerve cooler - Google Patents

Heat pipe nerve cooler Download PDF

Info

Publication number
US20020068964A1
US20020068964A1 US10/055,762 US5576202A US2002068964A1 US 20020068964 A1 US20020068964 A1 US 20020068964A1 US 5576202 A US5576202 A US 5576202A US 2002068964 A1 US2002068964 A1 US 2002068964A1
Authority
US
United States
Prior art keywords
cooling
evaporator
pain
nerve
spinal cord
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/055,762
Inventor
John Dobak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innercool Therapies Inc
Original Assignee
Innercool Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US09/012,287 priority Critical patent/US6051019A/en
Priority to US09/047,012 priority patent/US5957963A/en
Priority to US09/052,545 priority patent/US6231595B1/en
Priority to US09/103,342 priority patent/US6096068A/en
Priority to US09/215,040 priority patent/US6251130B1/en
Priority to US09/215,038 priority patent/US6261312B1/en
Priority to US09/262,805 priority patent/US6312452B1/en
Priority to US09/328,854 priority patent/US6364899B1/en
Application filed by Innercool Therapies Inc filed Critical Innercool Therapies Inc
Priority to US10/055,762 priority patent/US20020068964A1/en
Publication of US20020068964A1 publication Critical patent/US20020068964A1/en
Application status is Abandoned legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00292Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0231Characteristics of handpieces or probes
    • A61B2018/0262Characteristics of handpieces or probes using a circulating cryogenic fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12Devices for heating or cooling internal body cavities
    • A61F2007/126Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels

Abstract

The invention provides a method and apparatus for producing reversible focal hypothermia of the nervous system to control chronic pain. Nerve conduction is blocked by mild cooling (0 to 25° C.), or hypothermia. At these temperatures, nerve tissue is not destroyed and recovers completely when cooling is terminated, such that the treatment is reversible. By blocking conduction in pain nerves, pain sensation is eliminated in a manner analogous to drugs such as lidocaine that also block nerve conduction to provide anesthesia. The invention can be applied to a variety of conditions such as urge incontinence, muscle spasticity, and epilepsy. Many of these disorders are mediated by nerve and nervous tissue that could be interrupted by cooling. In addition, neurologic dysfunction found in multiple sclerosis may improve by cooling of the nerves. The method and apparatus may be used to cool areas of the nervous system affected by multiple sclerosis to allow more normal functions.

Description

    CROSS-REFERENCE TO RELATED APPLICATIONS
  • This application is a continuation of co-pending U.S. patent application Ser. No. 09/328,854, filed Jun. 9, 1999, entitled “Heat Pipe Nerve Cooler”, which is a continuation-in-part of the following U.S. patent applications: U.S. patent application Ser. No. 09/012,287, filed Jan. 23, 1998, entitled “Selective Organ Hypothermia Method and Apparatus”; U.S. patent application Ser. No. 09/047,012, filed Mar. 24, 1998, entitled “Improved Selective Organ Hypothermia Method and Apparatus”; U.S. patent application Ser. No. 09/052,545, filed Mar. 31, 1998, entitled “Circulating Fluid Hypothermia Method and Apparatus”; U.S. patent application Ser. No. 09/103,342, filed Jun. 23, 1998, entitled “A Selective Organ Cooling Catheter and Method of Using the Same”; U.S. patent application Ser. No. 09/215,038, filed Dec. 16, 1998, entitled “An Inflatable Catheter for Selective Organ Heating and Cooling Catheter and Method of Using the Same”; U.S. patent application Ser. No. 09/215,040, filed Dec. 16, 1998, entitled “Method and Device for Applications of Selective Organ Cooling”; and U.S. patent application Ser. No. 09/262,805, filed Mar. 4, 1999, entitled “A Selective Organ Cooling Catheter with Guide Wire Apparatus”, all of which are incorporated herein.[0001]
  • REFERENCE TO FEDERAL FUNDING
  • Not Applicable. [0002]
  • BACKGROUND OF THE INVENTION
  • Pain sensation is mediated by nerve fibers. Nerve fibers extend to the brain via the spinal cord which forms a portion of the central nervous system. Referring to FIG. 1, the spinal cord [0003] 12 extends from the brain to the level of the second lumbar vertebra, at which point the spinal cord branches to numerous individual roots. Throughout the length of the spinal cord, the same is encased in the vertebral canal. Nerves 14 branch off at regular intervals.
  • A number of types of nerves are disposed within the posterior gray horn [0004] 16. Two types of pain sensing nerves have been identified: Aδ and C. Referring to FIGS. 2 and 3, Aδ fibers 18 are disposed within regions I and V and the same produce a rapid initial and intense response to painful stimuli. C fibers 20 are disposed within region II and produce a more blunted but prolonged response. C fibers 20 are believed to be responsible for many chronic pain syndromes.
  • A[0005] δ fibers 18 and C fibers 20 are connected to the spinal cord 20 via the dorsal root 22 (referring back to FIG. 1). The dorsal root 22 is a bundle of nerves that enters the dorsal aspect of the spinal cord 12. The sensory nerves from one particular body region, such as the right leg, may be split among several dorsal root nerve bundles spaced along the length of the spinal cord 12.
  • Pain is conducted via fibers of the peripheral nervous system to the central nervous system, or nerves in the spinal cord. The pain signal is conducted up nerve tracts of the spinal cord to the pain sensing areas of the brain (i.e., the thalamus). The transmission of the pain signal from the peripheral nerves to the central nerves takes place in the synapses of the posterior gray horn region [0006] 16 of the spinal cord 12. A synapse is a neuron-to-neuron transmission of a signal by a chemical mediator that traverses a small gap between two axon terminals.
  • As noted above, many A[0007] δ fibers 18 and C fibers 20 synapse in the most superficial, or dorsal, region of the dorsal gray horn known as zones 1 and 2. The synaptic region of the C fibers 20 is also known as the substantia gelatinosa. Various treatments directed at these fibers and these anatomical locations, can be and are used to treat pain syndromes.
  • An estimated 15 million Americans suffer from chronic intractable pain. 50% of persons with terminal illness have significant pain and 10% require a surgical procedure to treat the pain. $80 billion is spent annually in the United States on chronic pain. [0008]
  • Current therapy for chronic pain can be divided into two categories: medical and surgical. Medical therapy is the administration of drugs ranging from Tylenol® to morphine. Morphine and its analogs are used in cases of severe pain and terminal illness. These drugs have many serious side effects such as sedation, confusion, constipation, and depression of respiration. The more severe the pain, the higher the dosage of the drug and the more significant the side effects. In addition, tolerance to these compounds develops, and escalating doses are required to achieve pain control. [0009]
  • Surgical therapy can range from the implantation of drug infusion devices to the ablation, or destruction, of nerves. Ablation of nervous tissue is irreversible and can cause permanent loss of function of organs and limbs. One type of surgical treatment is known as Dorsal Root Entry Zone (“DREZ”) ablation. The DREZ is shown in FIG. 1 as DREZ [0010] 24. While DREZ ablation is effective at treating pain, it can also result in significant limb and organ dysfunction. Drug infusion into the spinal cord using implanted devices can reduce drug side effects, however they do not eliminate side effects entirely nor solve the problem of tolerance. These approaches require significant surgical procedures; often, terminally ill patients are not good candidates for surgery.
  • Nerve stimulators are also used for pain control. These electrical devices work indirectly by stimulating nerve fibers that inhibit conduction pain fibers. It is known to place devices such as nerve stimulators surgically or percutaneously and they may be placed directly adjacent to the spinal cord. For example, U.S. Pat. No. 5,643,330 to Holsheimer et al., issued Jul. 1, 1997, and entitled “Multichannel Apparatus for Epidural Spinal Cord Stimulation”, discloses placing an epidural spinal cord stimulator adjacent to spinal cord dura mater. [0011]
  • Stimulators are relatively ineffective in controlling pain. This may be in part due to the indirect mechanism of action. Further, they can cause dysthesias and paresthesias (neurologenic pain) due to the stimulation of nerve fibers. [0012]
  • There is a need for a method and apparatus to combat pain, especially chronic pain, which do not suffer from the drawbacks of current medical and surgical therapies. [0013]
  • SUMMARY OF THE INVENTION
  • In one aspect, the invention is directed to a method of cooling a portion of a spinal cord of a patient. The method includes delivering a portion of a heat pipe to a spinal cord of a patient, the heat pipe including an evaporator and a condenser, including disposing the evaporator at least in partial thermal communication with the spinal cord. The evaporator is cooled by passing a working fluid between the evaporator and the condenser. [0014]
  • Implementations of the invention may include one or more of the following. The delivering may further include disposing the evaporator at least in partial thermal communication with the dorsal root entry zone of the spinal cord. The working fluid may be passed between the evaporator and the condenser through a conduit, and the conduit may be a tube or wick structure, for example. The condenser may be implanted within a patient or may be located externally of a patient. The condenser may have an insulated lower chamber into which the conduit enters and an upper chamber into which the return tube enters, the lower and upper chambers separated by a porous structure, and may further include passing the working fluid in gaseous form from the evaporator through the return tube within the conduit to the upper chamber, condensing the working fluid at least partially from the gaseous form into the liquid form, passing the working fluid from the upper chamber to the lower chamber through the porous structure, and passing the condensed working fluid from the lower chamber to the evaporator through the conduit. Another implementation may include disposing the upper chamber in thermal communication with a cold source. The evaporator may be disposed adjacent the dura mater, or between the spinal cord and the dura mater, or on the side of the dura mater opposite the spinal cord. [0015]
  • In another aspect, the invention is directed to an apparatus for cooling a portion of tissue. The apparatus includes an evaporator to be placed in thermal communication with a portion of tissue; a condenser disposed in thermal communication with a source or sink of heat, the condenser including an upper chamber and a lower chamber; and a conduit disposed between the evaporator and the condenser, the conduit including a wick structure, to communicate working fluid between the two. An implementation of the invention may include providing a porous structure to separate the lower chamber from the upper chamber. [0016]
  • Advantages of the invention include one or more of the following. The invention provides for control of chronic pain in an effective manner. The processes used to achieve hypothermia to control pain are reversible. Nerve tissue is not destroyed as in certain other techniques. Nerve tissue recovers completely when the processes are stopped. The invention allows for treatment of not only chronic pain but also urge incontinence, muscle spasticity, epilepsy, and may even be of benefit in treating multiple sclerosis.[0017]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a schematic drawing of the spinal cord. [0018]
  • FIG. 2 is a schematic cross-section of the spinal cord showing the anterior and posterior gray horn. [0019]
  • FIG. 3 is more detailed schematic cross-section of a portion of the spinal cord, showing the posterior horn and layers of nerve fibers therein. [0020]
  • FIG. 4 is a schematic cross-sectional side view of an embodiment of the invention, which may be implanted into a patient suffering chronic pain. [0021]
  • FIG. 5 is a schematic cross-sectional side view of an alternative embodiment of the invention, which may be implanted into a patient suffering chronic pain. [0022]
  • FIG. 6 is a schematic cross-sectional side view of another alternative embodiment of the invention, which may be implanted into a patient suffering chronic pain. [0023]
  • FIG. 7 is a schematic view of the embodiments of the invention shown in FIGS. [0024] 4-6 including a schematic of the same's placement within a patient.
  • FIG. 8 is a schematic view of an alternative embodiment of the invention including a schematic of the same's placement within a patient. [0025]
  • FIG. 9 is a more detailed schematic view of the placement of the invention alongside a patient's spinal cord.[0026]
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The invention provides, in one embodiment, a cooling catheter or cooling patch that can be placed on nerve fibers or tissue. When nerve tissue is cooled (+2° to +20° C.), conduction therethrough is stopped. Synaptic transmission is susceptible to termination by cooling, with near complete blockage of pain transmission occurring at +20° C. A A[0027] δ fibers are more susceptible to reduction of conduction via cooling and will be affected by warmer temperatures than C-fibers. For example, some A Aδ fibers will cease to conduct at +8° C. whereas the conduction of some C-fibers is substantially blocked at +3° C. This conduction block is known to be reversible. Normal conduction returns once the nerve warms.
  • In one method of controlling pain, described in more detail below, the cooling patch or catheter is placed parallel along the dorsal root entry zone [0028] 24 in contact with the spinal cord 12 or on the dura 26, a membrane that surrounds the cord (see FIGS. 1 and 9). The cooling section of the catheter or patch could be 5 to 10 cm long, or greater, and would stretch along several or many DREZs. This would substantially ensure the treatment of all pain fibers for a given body area that is the source of pain.
  • By placing the cooling device in the spinal cord [0029] 12, the synapses at the DREZ can be affected. Since these synapses are susceptible to termination or reduction of conduction at relatively warm temperatures, the temperature of the cooling device can be maintained at a reasonably warm temperature. For example, the surface of the cooling catheter may be maintained at +5° to +10° C. to produce cooling to +20° C. at the depth of the substantia gelatinosa 28 (FIG. 2), or 2-3 mm, at the DREZ 24.
  • One method of cooling employs a passive two-phase heat transfer device, or heat pipe. Referring to FIG. 4, a heat pipe [0030] 101 includes three basic parts: an evaporator 106, an intervening connecting conduit 104, and a condenser 102. The evaporator 106 and the condenser 102 are connected to each other by the conduit 104.
  • The conduit [0031] 104, which is insulated, allows a coolant to flow between the evaporator 106 and the condenser 102. The conduit 104 may employ a variety of structures. In FIG. 4, a capillary tube 122 is shown in which coolant flows by capillary forces. In FIG. 5, a conventional wick structure is shown. In FIG. 6, a cylindrical wick structure with a central return lumen is shown. In general, as shown in FIGS. 4-6, the conduit 104 includes a tube 114. Tube 114 defines a return path for gaseous coolant as will be described below.
  • In the heat pipe [0032] 101, heat enters from the body tissue and is absorbed by the evaporator 106. A liquid coolant such as a freon, within the evaporator 106, boils and absorbs the heat input, resulting in cooling. The vaporized freon then returns to the condenser 102 via a return tube 116 defined by tube 114 within the conduit 104. At the condenser 102, heat is removed, either by ambient air heat exchange or by cooling from another source. The cooled coolant condenses the gaseous coolant and the same then flows back down the conduit 104 to the evaporator 106.
  • The condenser [0033] 102 may be a small hollow metallic disc made from titanium, stainless steel, or other similar metals. The disk acts as a condenser and reservoir for a freon or other such working fluid. The disc has two chambers, an upper chamber 108 and a lower chamber 118. The lower chamber 118 may be insulated by an evacuated space 128 or other such insulation. There is no insulation on the upper chamber 108 of the disk or condenser 102. A porous/sintered disk 110 may optionally be used to separate the two halves. The conduit 104 enters the insulated lower chamber 118 or porous structure or disc 110. The evaporator conduit 116 enters the upper chamber 108 (i.e., the uninsulated half of the disk). The connection of the evaporator conduit 116 into the upper chamber 108 is indicated in FIGS. 4-6, although some details of the connection are omitted for clarity. At least one heat transfer fin 152 may be provided within the upper chamber to assist in the conduction of heat away from porous structure 110 to the cold source described below (for clarity, this fin 152 is only shown in FIG. 4).
  • In FIG. 4, the conduit [0034] 104 includes a capillary tube 122. The capillary tube 122 causes capillary forces to move the liquid coolant from the condenser 102 to the evaporator 106. The liquid inlet to the capillary tube 122 may be entirely within a lower chamber 118, described in more detail below, entirely within a porous disc 110, described in more detail above, or partly in both. In FIG. 4, the last embodiment is shown. In other words, liquid coolant may enter tube 122 through either of the porous disc 110 or the lower chamber 118.
  • In FIG. 5, the conduit [0035] 104 includes a wick structure 122′. The wick structure “wicks” the liquid coolant to the evaporator 106. Of course, it is understood that wick structures also employ capillary action, but in this embodiment the wick structure is distinguished from a capillary tube per se. Like the embodiment of FIG. 4, the wick structure 122′ may be connected either to the lower chamber 118, porous disc 110, or both. Also in this embodiment, the lower chamber 118 should be sealed so that only wick structure 122′ (and of course porous disc 110) may be inlets and outlets. In other words, evaporated gaseous coolant should be prohibited from entering lower chamber 118. The same is true of capillary tube 122.
  • In FIG. 6, a cylindrical wick structure [0036] 122″ is shown that provides an additional embodiment of the invention. In this embodiment, the wick structure 122″ approximately matches the inner diameter of the conduit 104. In this way, the wick structure 122″ is provided with more surface area and volume with which to wick coolant. The same travels down the wick structure 122″ to the evaporator. Once evaporated, the gaseous coolant may travel in the central lumen 116 defined by the wick structure 122″ itself back to the condenser 102. Of course, the wick structure 122″ in this embodiment is shaped such that coolant may reach even the upper portions of the wick structure 122″ (adjacent upper chamber 108) without entering the upper chamber 108. Nevertheless, most of the coolant may still travel along the portion of the wick structure adjacent the lower chamber 118. As above, the wick structure may contact the lower chamber 118 (as shown in FIG. 6) or may alternatively contact the porous disc 110, or both.
  • The evaporator [0037] 106 may be, e.g., a 1-2 mm outer diameter catheter disposed along the spinal cord, and may be, e.g., 10 to 15 cm in length. The evaporator 106 may have metal foil windows 126 that respectively align with the plurality of DREZ 24 thereby enhancing heat transfer. The evaporator 106 catheter can be made from polyimide and the metal foil windows 126 may be made of platinum or platinum iridium. It should be clear to one of skill in the art that the relative dimensions of the evaporator 106 in FIGS. 4-6 are greatly exaggerated and that most feasible such evaporators would have a ratio of length to width that is much greater than that shown in the figures.
  • The evaporator [0038] 106 is connected to the condenser 102 by the conduit 104. The conduit may reside in the tissue between the skin and the spinal cord. An end of the conduit 104 distal of evaporator 106 may be located between the skin and the spinal cord, and more preferably near the skin so as to allow thermal energy to be passed from the skin to the conduit and condenser, as well as vice-versa. In a separate embodiment, described in more detail below, conduit 104 may extend through a percutaneous incision to a region external of the body. It is also noted that the evaporator 106 may include a portion of the conduit 104 for better delivery of the coolant to the heat transfer portions of the evaporator.
  • In use, the evaporator [0039] 106 is inserted along and adjacent to the spinal cord 12 percutaneously with a needle introducer. The needle introducer allows the evaporator 106 to be disposed within the vertebra so as to be in thermal communication with the spinal cord 12. In this context, thermal communication refers to the ability of the evaporator 106 to absorb heat from the spinal cord 12. This thermal communication may arise from conduction, convection, or radiation. The evaporator 106 is slid along the spinal cord so as to achieve a high mutual surface area of contact.
  • Referring to FIG. 7, the condenser [0040] 102 is implanted just beneath the skin 30 with the uninsulated side (chamber 108) facing outward just underneath the skin 30. One way in which to start the cooling process is to place a cold pack 132 over the skin 30 adjacent the condenser 102. The cold pack 132 may be a thermoelectric cooler or an ice bag. Because the upper half (chamber 108) is uninsulated, it is cooled by the cold pack 132. The coldness condenses the coolant, which subsequently wicks through the porous separator 110 and enters the lower insulated half of the disk. Because the lower half (chamber 118) is insulated, the heat from the body does not allow the coolant to boil. It is noted that only a portion of the insulation of the lower chamber is shown in FIG. 7, for clarity. The coolant then flows down the capillary within conduit 104 to the evaporator 106 where it boils and cools the nerve tissue. The gaseous coolant returns to the upper chamber 108 of the condenser where it is cooled and liquefied, restarting the process. Removing the cold pack 132 terminates the cooling.
  • In an alternative embodiment, shown in FIG. 8, the condenser [0041] 102 is replaced with a cooling unit 102′ that is resident outside the body. In this embodiment, cooling unit 102′ provides and cycles a working fluid down a conduit to evaporator 106. Evaporator 106 may be similar in most or all aspects to the evaporator in previous embodiments. The coolant or working fluid flows back to cooling unit 102′ via a return tube. The conduit and return tube may be similar to the conduit and return tube described above.
  • In any of the embodiments, the coolant or working fluid may be a freon or other such type of refrigerant. In the alternative embodiment of FIG. 8, the working fluid may also be saline or other similar coolants. Saline may be employed in this embodiment at least in part because this embodiment need not rely on evaporation and condensation to propel the working fluid: rather, the cooling unit may supply the required pressure. [0042]
  • FIG. 9 shows one possible placement of the evaporator [0043] 106 along the spinal cord 12. In FIG. 9, the evaporator 106 is disposed along the spinal cord 12 subdurally, i.e., under the dura mater. It should be noted that the evaporator 106 may additionally be disposed epidurally, i.e., outside but adjacent to the dura mater.
  • While the invention has been described with respect to certain embodiments, it will be clear to those skilled in the art that variations of these embodiments may be employed which still fall within the scope of the invention. Accordingly, the scope of the invention is limited only by the claims appended hereto.[0044]

Claims (2)

What is claimed is:
1. An apparatus for cooling a portion of tissue, comprising:
an evaporator to be placed in thermal communication with a portion of tissue;
a condenser disposed in thermal communication with a source or sink of heat, the condenser including an upper chamber and a lower chamber; and
a conduit disposed between the evaporator and the condenser, the conduit including a wick structure, to communicate working fluid between the two.
2. The apparatus of claim 1, wherein the lower chamber is separated from the upper chamber by a porous structure.
US10/055,762 1998-01-23 2002-01-22 Heat pipe nerve cooler Abandoned US20020068964A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US09/012,287 US6051019A (en) 1998-01-23 1998-01-23 Selective organ hypothermia method and apparatus
US09/047,012 US5957963A (en) 1998-01-23 1998-03-24 Selective organ hypothermia method and apparatus
US09/052,545 US6231595B1 (en) 1998-03-31 1998-03-31 Circulating fluid hypothermia method and apparatus
US09/103,342 US6096068A (en) 1998-01-23 1998-06-23 Selective organ cooling catheter and method of using the same
US09/215,038 US6261312B1 (en) 1998-06-23 1998-12-16 Inflatable catheter for selective organ heating and cooling and method of using the same
US09/215,040 US6251130B1 (en) 1998-03-24 1998-12-16 Device for applications of selective organ cooling
US09/262,805 US6312452B1 (en) 1998-01-23 1999-03-04 Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US09/328,854 US6364899B1 (en) 1998-01-23 1999-06-09 Heat pipe nerve cooler
US10/055,762 US20020068964A1 (en) 1998-01-23 2002-01-22 Heat pipe nerve cooler

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/055,762 US20020068964A1 (en) 1998-01-23 2002-01-22 Heat pipe nerve cooler

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US09/328,854 Continuation US6364899B1 (en) 1998-01-23 1999-06-09 Heat pipe nerve cooler

Publications (1)

Publication Number Publication Date
US20020068964A1 true US20020068964A1 (en) 2002-06-06

Family

ID=27567471

Family Applications (2)

Application Number Title Priority Date Filing Date
US09/328,854 Expired - Fee Related US6364899B1 (en) 1998-01-23 1999-06-09 Heat pipe nerve cooler
US10/055,762 Abandoned US20020068964A1 (en) 1998-01-23 2002-01-22 Heat pipe nerve cooler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US09/328,854 Expired - Fee Related US6364899B1 (en) 1998-01-23 1999-06-09 Heat pipe nerve cooler

Country Status (1)

Country Link
US (2) US6364899B1 (en)

Cited By (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020151845A1 (en) * 2000-12-06 2002-10-17 Randell Werneth Multipurpose catheter assembly
US6533804B2 (en) 1998-01-23 2003-03-18 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6576001B2 (en) 2000-03-03 2003-06-10 Innercool Therapies, Inc. Lumen design for catheter
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
US20030125721A1 (en) * 1998-03-31 2003-07-03 Yon Steven A. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6595967B2 (en) 2001-02-01 2003-07-22 Innercool Therapies, Inc. Collapsible guidewire lumen
US6602276B2 (en) 1998-03-31 2003-08-05 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6676690B2 (en) 1999-10-07 2004-01-13 Innercool Therapies, Inc. Inflatable heat transfer apparatus
US6676688B2 (en) 1998-01-23 2004-01-13 Innercool Therapies, Inc. Method of making selective organ cooling catheter
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US6692488B2 (en) 1998-01-23 2004-02-17 Innercool Therapies, Inc. Apparatus for cell necrosis
US6702842B2 (en) 1998-01-23 2004-03-09 Innercool Therapies, Inc. Selective organ cooling apparatus and method
US20040210285A1 (en) * 2002-04-04 2004-10-21 Steven Yon Method of manufacturing a heat transfer element for in vivo cooling without undercuts
EP1514529A1 (en) * 2002-06-17 2005-03-16 Atsuo Mori Catheter for topical cooling and topical cooling device using the same
US20060064146A1 (en) * 2004-09-17 2006-03-23 Collins Kenneth A Heating/cooling system for indwelling heat exchange catheter
US20060089689A1 (en) * 2004-10-22 2006-04-27 Hennemann Willard W Method and device for local cooling within an organ using an intravascular device
US20060111743A1 (en) * 2004-11-19 2006-05-25 Gurney Harry C Jr Method for arresting seizure activity
US20060190062A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for reducing shivering when using external cooling pads
US20060200215A1 (en) * 2005-03-01 2006-09-07 Collins Kenneth A System and method for treating cardiac arrest and myocardial infarction
US20060235496A1 (en) * 2005-04-18 2006-10-19 Collins Kenneth A External heat exchange pad for patient
US20060276864A1 (en) * 2005-06-03 2006-12-07 Alsius Corporation Systems and methods for sensing patient temperature in temperature management system
US20060293732A1 (en) * 2005-06-27 2006-12-28 Collins Kenneth A Thermoelectric cooler (TEC) heat exchanger for intravascular heat exchange catheter
US20070000278A1 (en) * 2005-07-01 2007-01-04 Collins Kenneth A Primary heat exchanger for patient temperature control
US20070016270A1 (en) * 2005-07-14 2007-01-18 Stelica Stelea System and method for leak detection in external cooling pad
US20080039911A1 (en) * 2004-06-01 2008-02-14 Philippe Koninckx Adhesion Prevention and an Intra-Luminal Cooling System Therefor
US20080119788A1 (en) * 2006-11-21 2008-05-22 Suzanne Winter Temperature management system and method for burn patients
US20080243212A1 (en) * 2007-03-29 2008-10-02 Cardiac Pacemakers, Inc. Systems and methods for thermal neuroinhibition
US20080287919A1 (en) * 2007-05-18 2008-11-20 David Searl Kimball System and method for effecting non-standard fluid line connections
US20090149798A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Implant system for chemical modulation of neural activity
US20090149926A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for thermal modulation of neural activity
US20090149897A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for transdermal chemical modulation of neural activity
US20090149799A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for chemical modulation of neural activity
US20090149911A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for electrical modulation of neural conduction
US20090149693A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for magnetic modulation of neural conduction
US20090149694A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for magnetic modulation of neural conduction
US20090149797A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for reversible chemical modulation of neural activity
US7822485B2 (en) 2006-09-25 2010-10-26 Zoll Circulation, Inc. Method and apparatus for spinal cooling
US7857781B2 (en) 1998-04-21 2010-12-28 Zoll Circulation, Inc. Indwelling heat exchange catheter and method of using same
US7867266B2 (en) 2006-11-13 2011-01-11 Zoll Circulation, Inc. Temperature management system with assist mode for use with heart-lung machine
US7951183B2 (en) 1998-01-23 2011-05-31 Innercool Therapies, Inc. Medical procedure
US8043283B2 (en) 1998-03-31 2011-10-25 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US8163000B2 (en) 1998-01-23 2012-04-24 Innercool Therapies, Inc. Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8353893B2 (en) 2007-03-07 2013-01-15 Zoll Circulation, Inc. System and method for rapidly cooling cardiac arrest patient
US9023023B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9023022B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device having release instrument
US9033966B2 (en) 2013-03-15 2015-05-19 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9131975B2 (en) 2013-03-15 2015-09-15 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9186197B2 (en) 2013-03-15 2015-11-17 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device for treating pain
US9198707B2 (en) 2013-03-15 2015-12-01 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device and method
US9241754B2 (en) 2013-03-15 2016-01-26 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9895190B2 (en) 2014-04-28 2018-02-20 Warsaw Orthopedic, Inc. Devices and methods for radiofrequency ablation having at least two electrodes

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869440B2 (en) * 1999-02-09 2005-03-22 Innercool Therapies, Inc. Method and apparatus for patient temperature control employing administration of anti-shivering agents
US6576002B2 (en) 1998-03-24 2003-06-10 Innercool Therapies, Inc. Isolated selective organ cooling method and apparatus
WO2003015672A1 (en) * 2001-08-15 2003-02-27 Innercool Therapies, Inc. Method and apparatus for patient temperature control employing administration of anti-shivering
US6599312B2 (en) 1998-03-24 2003-07-29 Innercool Therapies, Inc. Isolated selective organ cooling apparatus
US6991645B2 (en) * 1998-01-23 2006-01-31 Innercool Therapies, Inc. Patient temperature regulation method and apparatus
US6830581B2 (en) * 1999-02-09 2004-12-14 Innercool Therspies, Inc. Method and device for patient temperature control employing optimized rewarming
US6471717B1 (en) * 1998-03-24 2002-10-29 Innercool Therapies, Inc. Selective organ cooling apparatus and method
US6905494B2 (en) * 1998-03-31 2005-06-14 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US6648906B2 (en) 2000-04-06 2003-11-18 Innercool Therapies, Inc. Method and apparatus for regulating patient temperature by irrigating the bladder with a fluid
US6383210B1 (en) 2000-06-02 2002-05-07 Innercool Therapies, Inc. Method for determining the effective thermal mass of a body or organ using cooling catheter
US6761715B2 (en) * 2001-04-26 2004-07-13 Ronald J. Carroll Method and device for neurocryo analgesia and anesthesia
US6430956B1 (en) * 2001-05-15 2002-08-13 Cimex Biotech Lc Hand-held, heat sink cryoprobe, system for heat extraction thereof, and method therefore
US6746474B2 (en) * 2002-05-31 2004-06-08 Vahid Saadat Apparatus and methods for cooling a region within the body
US20040024392A1 (en) * 2002-08-05 2004-02-05 Lewis James D. Apparatus and method for cryosurgery
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
US7613515B2 (en) * 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
US7444183B2 (en) * 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US20040172084A1 (en) * 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7844338B2 (en) * 2003-02-03 2010-11-30 Enteromedics Inc. High frequency obesity treatment
US7520862B2 (en) * 2004-02-03 2009-04-21 Neuro Diagnostic Devices, Inc. Cerebral spinal fluid shunt evaluation system
US20060136023A1 (en) * 2004-08-26 2006-06-22 Dobak John D Iii Method and apparatus for patient temperature control employing administration of anti-shivering agents
US7070612B1 (en) 2005-02-23 2006-07-04 Alsius Corporation System and method for bringing hypothermia rapidly onboard
US7713266B2 (en) * 2005-05-20 2010-05-11 Myoscience, Inc. Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
US20070021809A1 (en) * 2005-07-22 2007-01-25 Cole Pamela S Vagina and vulva cooling and heating device
US7822486B2 (en) * 2005-08-17 2010-10-26 Enteromedics Inc. Custom sized neural electrodes
US7672727B2 (en) * 2005-08-17 2010-03-02 Enteromedics Inc. Neural electrode treatment
US20070225781A1 (en) * 2006-03-21 2007-09-27 Nidus Medical, Llc Apparatus and methods for altering temperature in a region within the body
US20090082832A1 (en) * 2007-09-25 2009-03-26 Boston Scientific Neuromodulation Corporation Thermal Management of Implantable Medical Devices
US8165694B2 (en) * 2008-01-29 2012-04-24 Boston Scientific Neuromodulation Corporation Thermal management of implantable medical devices
US9079031B2 (en) * 2008-09-11 2015-07-14 Trifectas Medical Corp. Method for improving functional recovery after stroke by electrical stimulation of a cranial nerve
KR101027599B1 (en) * 2008-11-18 2011-04-06 (주)메디슨 Ultrasound system and method providing acoustic radiation force impulse imaging with high frame rate
US8591562B2 (en) * 2008-12-02 2013-11-26 University Of Washington Methods and devices for brain cooling for treatment and prevention of acquired epilepsy
US9522081B2 (en) 2008-12-02 2016-12-20 University Of Washington Methods and devices for brain cooling for treatment and/or prevention of epileptic seizures
CA2758944A1 (en) * 2009-04-22 2010-10-28 Konstantinos Alataris Spinal cord modulation for inducing paresthetic and anesthetic effects, and associated systems and methods
US8825164B2 (en) 2010-06-11 2014-09-02 Enteromedics Inc. Neural modulation devices and methods
US8805519B2 (en) 2010-09-30 2014-08-12 Nevro Corporation Systems and methods for detecting intrathecal penetration
US9283110B2 (en) * 2011-09-20 2016-03-15 Zoll Circulation, Inc. Patient temperature control catheter with outer sleeve cooled by inner sleeve
WO2014146127A1 (en) 2013-03-15 2014-09-18 Myoscience, Inc. Methods and systems for treatment of spasticity
US20150230973A1 (en) 2014-02-14 2015-08-20 Zoll Cirulation, Inc. Fluid cassette with tensioned polymeric membranes for patient heat exchange system
DE102016201912A1 (en) * 2016-02-09 2017-08-10 ITP GmbH Gesellschaft für intelligente textile Produkte Temperature control device and helmet
US10117580B1 (en) 2017-05-06 2018-11-06 Synerfuse, Inc. Systems, devices and methods that affect neural tissue through the delivery of a pulsed radio frequency signal generated by an implantable medical device

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352514B1 (en) * 1996-05-17 2002-03-05 Amira Medical Methods and apparatus for sampling and analyzing body fluid

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2672032A (en) 1951-10-19 1954-03-16 Towse Robert Albert Edward Carcass freezing device
US3425419A (en) 1964-08-08 1969-02-04 Angelo Actis Dato Method of lowering and raising the temperature of the human body
WO1991005528A1 (en) 1989-10-19 1991-05-02 Granulab B.V. Device for cooling or heating a person
US5624392A (en) 1990-05-11 1997-04-29 Saab; Mark A. Heat transfer catheters and methods of making and using same
US5417686A (en) 1990-07-10 1995-05-23 The Texas A&M University System Temperature control mechanisms for a micro heat pipe catheter
US5190539A (en) 1990-07-10 1993-03-02 Texas A & M University System Micro-heat-pipe catheter
US5121754A (en) 1990-08-21 1992-06-16 Medtronic, Inc. Lateral displacement percutaneously inserted epidural lead
US5207674A (en) * 1991-05-13 1993-05-04 Hamilton Archie C Electronic cryogenic surgical probe apparatus and method
US5269369A (en) 1991-11-18 1993-12-14 Wright State University Temperature regulation system for the human body using heat pipes
US5403281A (en) 1992-09-25 1995-04-04 Minnesota Mining And Manufacturing Company Inline heat exchanger and cardioplegia system
US5486208A (en) 1993-02-10 1996-01-23 Ginsburg; Robert Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US6110168A (en) 1993-02-10 2000-08-29 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modifications
US5837003A (en) 1993-02-10 1998-11-17 Radiant Medical, Inc. Method and apparatus for controlling a patient's body temperature by in situ blood temperature modification
US5571147A (en) 1993-11-02 1996-11-05 Sluijter; Menno E. Thermal denervation of an intervertebral disc for relief of back pain
US5462521A (en) 1993-12-21 1995-10-31 Angeion Corporation Fluid cooled and perfused tip for a catheter
US5501703A (en) 1994-01-24 1996-03-26 Medtronic, Inc. Multichannel apparatus for epidural spinal cord stimulator
US5676691A (en) 1994-09-21 1997-10-14 Friedman; Mark H. Treatment of vascular and tension headache, atypical facial pain, and cervical muscle hyperactivity
US6033383A (en) 1996-12-19 2000-03-07 Ginsburg; Robert Temperature regulating catheter and methods
US5879329A (en) 1997-01-22 1999-03-09 Radiant Medical, Inc. Infusion systems and methods for introducing fluids into the body within a desired temperature range
US5899898A (en) 1997-02-27 1999-05-04 Cryocath Technologies Inc. Cryosurgical linear ablation
US6096068A (en) 1998-01-23 2000-08-01 Innercool Therapies, Inc. Selective organ cooling catheter and method of using the same
CA2310223C (en) 1998-03-24 2005-01-04 Del Mar Medical Technologies, Inc. Selective organ cooling apparatus and method
US6261312B1 (en) 1998-06-23 2001-07-17 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6491716B2 (en) 1998-03-24 2002-12-10 Innercool Therapies, Inc. Method and device for applications of selective organ cooling
US6051019A (en) 1998-01-23 2000-04-18 Del Mar Medical Technologies, Inc. Selective organ hypothermia method and apparatus
US6042559A (en) 1998-02-24 2000-03-28 Innercool Therapies, Inc. Insulated catheter for selective organ perfusion
US6126684A (en) 1998-04-21 2000-10-03 The Regents Of The University Of California Indwelling heat exchange catheter and method of using same
US6338727B1 (en) 1998-08-13 2002-01-15 Alsius Corporation Indwelling heat exchange catheter and method of using same
US6620188B1 (en) 1998-08-24 2003-09-16 Radiant Medical, Inc. Methods and apparatus for regional and whole body temperature modification
US6146411A (en) 1998-12-24 2000-11-14 Alsius Corporation Cooling system for indwelling heat exchange catheter
EP1029520B1 (en) 1999-02-19 2002-08-14 Alsius Corporation Central venous line catheter having temperature control system
US6019783A (en) 1999-03-02 2000-02-01 Alsius Corporation Cooling system for therapeutic catheter

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352514B1 (en) * 1996-05-17 2002-03-05 Amira Medical Methods and apparatus for sampling and analyzing body fluid

Cited By (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6692488B2 (en) 1998-01-23 2004-02-17 Innercool Therapies, Inc. Apparatus for cell necrosis
US6533804B2 (en) 1998-01-23 2003-03-18 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6540771B2 (en) 1998-01-23 2003-04-01 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US7998182B2 (en) 1998-01-23 2011-08-16 Innercool Therapies, Inc. Selective organ cooling apparatus
US7766949B2 (en) 1998-01-23 2010-08-03 Innercool Therapies, Inc. Fever regulation method and apparatus
US8163000B2 (en) 1998-01-23 2012-04-24 Innercool Therapies, Inc. Selective organ cooling catheter with guidewire apparatus and temperature-monitoring device
US7651518B2 (en) 1998-01-23 2010-01-26 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6702842B2 (en) 1998-01-23 2004-03-09 Innercool Therapies, Inc. Selective organ cooling apparatus and method
US6648908B2 (en) 1998-01-23 2003-11-18 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6695873B2 (en) 1998-01-23 2004-02-24 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US6676688B2 (en) 1998-01-23 2004-01-13 Innercool Therapies, Inc. Method of making selective organ cooling catheter
US6676689B2 (en) 1998-01-23 2004-01-13 Innercool Therapies, Inc. Inflatable catheter for selective organ heating and cooling and method of using the same
US7951183B2 (en) 1998-01-23 2011-05-31 Innercool Therapies, Inc. Medical procedure
US6685732B2 (en) 1998-03-31 2004-02-03 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing microporous balloon
US8043283B2 (en) 1998-03-31 2011-10-25 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US6602276B2 (en) 1998-03-31 2003-08-05 Innercool Therapies, Inc. Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US8157794B2 (en) 1998-03-31 2012-04-17 Innercool Therapies, Inc. Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation
US20030125721A1 (en) * 1998-03-31 2003-07-03 Yon Steven A. Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection
US8128595B2 (en) 1998-04-21 2012-03-06 Zoll Circulation, Inc. Method for a central venous line catheter having a temperature control system
US7857781B2 (en) 1998-04-21 2010-12-28 Zoll Circulation, Inc. Indwelling heat exchange catheter and method of using same
US6585752B2 (en) 1998-06-23 2003-07-01 Innercool Therapies, Inc. Fever regulation method and apparatus
US6676690B2 (en) 1999-10-07 2004-01-13 Innercool Therapies, Inc. Inflatable heat transfer apparatus
US6576001B2 (en) 2000-03-03 2003-06-10 Innercool Therapies, Inc. Lumen design for catheter
US20020151845A1 (en) * 2000-12-06 2002-10-17 Randell Werneth Multipurpose catheter assembly
US6719723B2 (en) 2000-12-06 2004-04-13 Innercool Therapies, Inc. Multipurpose catheter assembly
US6595967B2 (en) 2001-02-01 2003-07-22 Innercool Therapies, Inc. Collapsible guidewire lumen
US7288109B2 (en) 2002-04-04 2007-10-30 Innercool Therapies. Inc. Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US8172889B2 (en) 2002-04-04 2012-05-08 Innercoll Therapies, Inc. Method of manufacturing a heat transfer element for in vivo cooling without undercuts
US20040210285A1 (en) * 2002-04-04 2004-10-21 Steven Yon Method of manufacturing a heat transfer element for in vivo cooling without undercuts
EP1514529A4 (en) * 2002-06-17 2006-08-16 Atsuo Mori Catheter for topical cooling and topical cooling device using the same
US8303637B2 (en) 2002-06-17 2012-11-06 Atsuo Mori Catheter for topical cooling and topical cooling device using the same
US20050222652A1 (en) * 2002-06-17 2005-10-06 Atsuo Mori Catheter for topical cooling and topical cooling device using the same
EP1514529A1 (en) * 2002-06-17 2005-03-16 Atsuo Mori Catheter for topical cooling and topical cooling device using the same
US20080275535A1 (en) * 2002-06-17 2008-11-06 Atsuo Mori Catheter for Topical Cooling and Topical Cooling Device using the same
JP2010088914A (en) * 2002-06-17 2010-04-22 Atsuo Mori Catheter for topical cooling and topical cooling device using the same
US20080039911A1 (en) * 2004-06-01 2008-02-14 Philippe Koninckx Adhesion Prevention and an Intra-Luminal Cooling System Therefor
US20060064146A1 (en) * 2004-09-17 2006-03-23 Collins Kenneth A Heating/cooling system for indwelling heat exchange catheter
US8672988B2 (en) 2004-10-22 2014-03-18 Medtronic Cryocath Lp Method and device for local cooling within an organ using an intravascular device
US20060089689A1 (en) * 2004-10-22 2006-04-27 Hennemann Willard W Method and device for local cooling within an organ using an intravascular device
US20060111743A1 (en) * 2004-11-19 2006-05-25 Gurney Harry C Jr Method for arresting seizure activity
US20060190062A1 (en) * 2005-02-23 2006-08-24 Worthen William J System and method for reducing shivering when using external cooling pads
US20060200215A1 (en) * 2005-03-01 2006-09-07 Collins Kenneth A System and method for treating cardiac arrest and myocardial infarction
US7892269B2 (en) 2005-04-18 2011-02-22 Zoll Circulation, Inc. External heat exchange pad for patient
US20060235496A1 (en) * 2005-04-18 2006-10-19 Collins Kenneth A External heat exchange pad for patient
US20060276864A1 (en) * 2005-06-03 2006-12-07 Alsius Corporation Systems and methods for sensing patient temperature in temperature management system
US20060293732A1 (en) * 2005-06-27 2006-12-28 Collins Kenneth A Thermoelectric cooler (TEC) heat exchanger for intravascular heat exchange catheter
US20070000278A1 (en) * 2005-07-01 2007-01-04 Collins Kenneth A Primary heat exchanger for patient temperature control
US7951182B2 (en) 2005-07-14 2011-05-31 Zoll Circulation, Inc. System and method for leak detection in external cooling pad
US20070016270A1 (en) * 2005-07-14 2007-01-18 Stelica Stelea System and method for leak detection in external cooling pad
US9180042B2 (en) 2006-09-25 2015-11-10 Zoll Circulation, Inc. Method and apparatus for spinal cooling
US7822485B2 (en) 2006-09-25 2010-10-26 Zoll Circulation, Inc. Method and apparatus for spinal cooling
US7867266B2 (en) 2006-11-13 2011-01-11 Zoll Circulation, Inc. Temperature management system with assist mode for use with heart-lung machine
US20080119788A1 (en) * 2006-11-21 2008-05-22 Suzanne Winter Temperature management system and method for burn patients
US7892270B2 (en) 2006-11-21 2011-02-22 Zoll Circulation Inc. Temperature management system and method for burn patients
US8353893B2 (en) 2007-03-07 2013-01-15 Zoll Circulation, Inc. System and method for rapidly cooling cardiac arrest patient
US8734499B2 (en) * 2007-03-29 2014-05-27 Cardiac Pacemakers, Inc. Systems and methods for thermal neuroinhibition
US20080243212A1 (en) * 2007-03-29 2008-10-02 Cardiac Pacemakers, Inc. Systems and methods for thermal neuroinhibition
US9737692B2 (en) 2007-05-18 2017-08-22 Zoll Circulation, Inc. System and method for effecting non-standard fluid line connections
US20080287919A1 (en) * 2007-05-18 2008-11-20 David Searl Kimball System and method for effecting non-standard fluid line connections
US20090149914A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for reversible chemical modulation of neural activity
GB2467882A (en) * 2007-12-05 2010-08-18 Searete Llc System for thermal modulation of neural activity
US20090149797A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for reversible chemical modulation of neural activity
WO2009073208A1 (en) * 2007-12-05 2009-06-11 Searete Llc System for thermal modulation of neural activity
US8160695B2 (en) 2007-12-05 2012-04-17 The Invention Science Fund I, Llc System for chemical modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US20090149694A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for magnetic modulation of neural conduction
US20090149798A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Implant system for chemical modulation of neural activity
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US20090149693A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for magnetic modulation of neural conduction
US8180447B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method for reversible chemical modulation of neural activity
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US9789315B2 (en) 2007-12-05 2017-10-17 Gearbox, Llc Method and system for modulating neural activity
US8170660B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for thermal modulation of neural activity
GB2467882B (en) * 2007-12-05 2012-12-05 Searete Llc System for thermal modulation of neural activity
US20090149799A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for chemical modulation of neural activity
US8630706B2 (en) 2007-12-05 2014-01-14 The Invention Science Fund I, Llc Method and system for reversible chemical modulation of neural activity
US20090149896A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for chemical modulation of neural activity
US20090149897A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for transdermal chemical modulation of neural activity
US8989858B2 (en) 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US20090149926A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for thermal modulation of neural activity
US9020591B2 (en) 2007-12-05 2015-04-28 The Invention Science Fund I, Llc Method and system for ultrasonic neural modulation in a limb
US9020592B2 (en) 2007-12-05 2015-04-28 The Invention Science Fund I, Llc Method and system for blocking nerve conduction
US9358374B2 (en) 2007-12-05 2016-06-07 Gearbox, Llc Method and system for blocking nerve conduction
US10092692B2 (en) 2007-12-05 2018-10-09 Gearbox, Llc Method and system for modulating neural activity
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US20090149911A1 (en) * 2007-12-05 2009-06-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware System for electrical modulation of neural conduction
US9014802B2 (en) 2007-12-05 2015-04-21 The Invention Science Fund I, Llc Method and system for modulating neural activity in a limb
US9033966B2 (en) 2013-03-15 2015-05-19 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9198707B2 (en) 2013-03-15 2015-12-01 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device and method
US9241754B2 (en) 2013-03-15 2016-01-26 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9320559B2 (en) 2013-03-15 2016-04-26 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device having release instrument
US9023023B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9186197B2 (en) 2013-03-15 2015-11-17 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device for treating pain
US9023022B2 (en) 2013-03-15 2015-05-05 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device having release instrument
US9131975B2 (en) 2013-03-15 2015-09-15 Warsaw Orthopedic, Inc. Nerve and soft tissue ablation device
US9895190B2 (en) 2014-04-28 2018-02-20 Warsaw Orthopedic, Inc. Devices and methods for radiofrequency ablation having at least two electrodes

Also Published As

Publication number Publication date
US6364899B1 (en) 2002-04-02

Similar Documents

Publication Publication Date Title
Bosch et al. Sacral (S3) segmental nerve stimulation as a treatment for urge incontinence in patients with detrusor instability: results of chronic electrical stimulation using an implantable neural prosthesis
US8504147B2 (en) Systems and methods for neuromodulation for treatment of pain and other disorders associated with nerve conduction
US6530946B1 (en) Indwelling heat exchange heat pipe catheter and method of using same
US6185455B1 (en) Method of reducing the incidence of medical complications using implantable microstimulators
Arias Percutaneous radio-frequency thermocoagulation with low temperature in the treatment of essential glossopharyngeal neuralgia
US6613044B2 (en) Selective delivery of cryogenic energy to intervertebral disc tissue and related methods of intradiscal hypothermia therapy
US5112303A (en) Tumor access device and method for delivering medication into a body cavity
US7252665B2 (en) Ablation of stomach lining to reduce stomach acid secretion
US8715275B2 (en) Pain management using cryogenic remodeling
Sanders et al. Efficacy of sphenopalatine ganglion blockade in 66 patients suffering from cluster headache: a 12-to 70-month follow-up evaluation
EP1890627B1 (en) Subdermal cryogenic remodeling of muscles, nerves, connective tissue, and/or adipose tissue (fat)
JP3554330B2 (en) Cryo mapping and ablation catheter
US8066702B2 (en) Combination electrical stimulating and infusion medical device and method
US6652445B1 (en) Treatment of afflictions ailments and diseases
CA2607018C (en) Indwelling heat exchange catheter and method of using same
US7072719B2 (en) Implantable percutaneous stimulation lead with interlocking elements
ES2254297T3 (en) Spinal medula stimulation driver cable.
US7778704B2 (en) Electrical stimulation of the sympathetic nerve chain
US8805533B2 (en) Systems and methods of neuromodulation stimulation for the restoration of sexual function
JP5650137B2 (en) Electric muscle stimulation system and method using energy induction area
KR100957458B1 (en) Early intervention spinal treatment methods and devices for use therein
US6418344B1 (en) Method of treating psychiatric disorders by electrical stimulation within the orbitofrontal cerebral cortex
AU756115B2 (en) Temperature regulating catheter and methods
US20070179559A1 (en) Electrical stimulation to alleviate chronic pelvic pain
Paicius et al. Peripheral nerve field stimulation for the treatment of chronic low back pain: preliminary results of long‐term follow‐up: a case series

Legal Events

Date Code Title Description
STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION