US20020040713A1 - Dry powder inhaler - Google Patents
Dry powder inhaler Download PDFInfo
- Publication number
- US20020040713A1 US20020040713A1 US10/007,617 US761701A US2002040713A1 US 20020040713 A1 US20020040713 A1 US 20020040713A1 US 761701 A US761701 A US 761701A US 2002040713 A1 US2002040713 A1 US 2002040713A1
- Authority
- US
- United States
- Prior art keywords
- inhaler
- housing
- chamber
- duct
- staging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
- A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0031—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0024—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with an on-off output signal, e.g. from a switch
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
Definitions
- the field of the invention is inhalers. More specifically, the invention relates to inhalers for delivering drugs in a solid finely divided dry powder or fluid form.
- Inhalers are used to deliver drugs into a patient's lungs.
- an inhaler typically contains or provides a mixture of drugs and air or propellants.
- the mixture is delivered via the patient inhaling from a mouthpiece on the inhaler, for treatment of various conditions, for example, bronchial asthma.
- delivery of drugs via inhalation can be used for many other treatments, including those unrelated to lung condition.
- the present inhaler preferably includes a cover plate pivotably attached to a lid on an inhaler housing.
- a blister pack disk is rotatably mounted on the housing under the cover plate, and is movable in a single forward direction.
- An actuator in the housing is most desirably aligned with a lever on the cover plate. The patient pushes the actuator which shears open a blister on the disk and then causes the lever to crush the blister, to deliver the drug powder contents of the blister into a duct within the housing, for subsequent inhalation by the patient.
- FIG. 1 is perspective view of the present inhaler with the mouthpiece covered by the cover assembly
- FIG. 2 is a perspective view thereof with the mouthpiece uncovered
- FIG. 3 is a plan view of the inhaler as shown in FIG. 1;
- FIG. 4 is a plan view of the inhaler as shown in FIG. 2;
- FIG. 5 is an exploded perspective view of the inhaler of FIGS. 1 and 2;
- FIG. 6 is an plan view of the inhaler of FIGS. 1 and 2 with the lid open;
- FIG. 7 is a partial section view taken along line 7 - 7 of FIG. 6;
- FIG. 8 is an enlarged top and front perspective view of the cover assembly on the inhalers of FIGS. 1 and 2;
- FIG. 9 is a bottom and rear perspective view of the cover assembly of FIG. 8;
- FIG. 10 is an enlarged view of features shown in FIG. 9;
- FIG. 11 is a partial section view taken along line 11 - 11 of FIG. 5;
- FIG. 12 is similar view showing positions of various components during use of the device.
- FIG. 13 is a partial section view taken along line 13 - 13 of FIG. 3;
- FIG. 14 is a partial section view taken along line 14 - 14 of FIG. 4;
- FIGS. 15, 16 and 17 are partial section view fragments illustrating movement of components within the device
- FIG. 18 is a section view taken along line 18 - 18 of FIG. 5;
- FIG. 19 is a similar view thereof with various components omitted for drawing clarity, and showing positions of components during use;
- FIG. 20 is an exploded perspective view of a blister disk for use with the inhaler shown in FIGS. 1 and 2;
- FIG. 21 is a partial plan view thereof.
- FIG. 22 is a section view taken along line 22 - 22 of FIG. 21.
- a dry powder inhaler includes a housing 32 having a lid 38 attached to the housing with a hinge 36 .
- the lid 38 is preferably a transparent material, e.g., clear plastic.
- a removable mouthpiece 34 is provided on one side of the housing 32 .
- a sliding cover assembly 40 may be pivoted on the lid 38 from a closed position covering the mouthpiece 34 , as shown in FIGS. 1 and 3, to an opened position exposing the mouthpiece 34 , as shown in FIGS. 2 and 4. As best shown in FIGS.
- a disk 42 having a plurality of radially spaced apart blisters 44 is generally centered on top of the housing 32 on a center post 140 extending upwardly from the housing 32 .
- a lid stop 46 on the housing 32 limits sliding movement of the cover assembly 40 in the opened position.
- the sliding cover assembly 40 includes an enclosure 48 having a front curved wall 54 , a side wall 56 , a top wall 58 and a bottom wall 60 .
- a rim 62 extends upwardly and radially inwardly on the top wall 58 .
- a glide block 64 and an outside retainer 66 extend downwardly and inwardly on the underside of the top wall 58 .
- a generally flat cover plate 50 is preferably integrally formed with the enclosure 48 , with the cover plate 50 and enclosure comprising the cover assembly 40 .
- An inside retainer 68 on the cover plate 50 extends radially outwardly.
- a lever 74 is pivotably supported on a lever pin 76 held in place by lever blocks 72 on the underside of the cover plate 50 .
- the lever 74 can pivot through a lever opening 78 in the cover plate 50 , as best shown in FIG. 8.
- a ramp 80 and a guide wall 82 project downwardly from the cover plate 50 , adjacent to the lever 74 , as shown in FIG. 9.
- the entire cover assembly 40 which includes the enclosure 48 and cover plate 50 is pivotably attached to the lid 38 , with the lid post 52 extending through a center hub 84 on the cover plate 50 .
- Clearance holes 70 through the cover plate 50 on either side of the lever opening 78 allow the cover plate to sit on top of the blister disk, as shown in FIG. 18, without excessive vertical interference.
- a spring arm 86 having a downwardly projecting end tab 88 is attached to or integral with the cover plate 50 .
- the spring arm 86 includes an arm wedge 96 at its free end, alongside the tab 88 .
- an arm lifter 102 extends downwardly from the lid 38 .
- An outer slot 94 through the cover plate 50 overlies the spring arm 86 .
- An inner slot 92 adjoining the outer slot 94 through the cover plate 50 provides clearance for the arm lifter 102 , and allows the cover assembly 40 to rotate (preferably about 90°).
- the arm lifter 102 includes an internal ramp, and is dimensioned to engage the arm wedge 96 , and lift the arm 86 up towards the lid 38 , as the arm wedge 96 moves into full engagement with the lifter 102 .
- the housing 32 includes a mixing chamber 120 , and a staging chamber 124 connected to the mixing chamber 120 via a duct 122 .
- an inlet duct 126 extends from one side of the housing 32 to the staging chamber 124 via a duct recess 130 .
- a crescent barrier 128 around the top of the staging chamber 124 creates an indirect air flow path from outside of the housing, through the inlet duct 126 and into the staging chamber 124 .
- a pressure port or opening 132 in the housing 32 alongside the mixing chamber 120 connects to a pressure switch 170 via a tube 172 .
- the pressure port aligns with a mouthpiece port 135 leading into the central opening of the mouthpiece. This provides a continuous duct from the mouthpiece opening to the pressure switch.
- the mouthpiece 34 or an alternative embodiment mouthpiece 136 is secured to the housing 32 with a hook 134 .
- the mouthpiece is removable by twisting or rotating the mouthpiece, to disengage the hook 134 , and then by pulling it off.
- Rachet posts 142 having angled top surfaces project slightly above the flat top surface 138 of the housing 32 .
- An actuation button 146 has a post 148 extending entirely through a post opening 144 in the housing 32 .
- a detent 145 on the housing engages and holds the post 148 in the up position (driving the lever to crush a blister), until the disk is advanced to the next blister.
- At the front of the housing, behind the mixing chamber 120 is an inwardly projecting housing inner rim 150 , and an outwardly projecting housing outer rim 152 .
- the outer rim 152 is engaged by the outside retainer 66
- the inner rim is engaged by the inside retainer 68 , as the cover assembly 40 is moved between opened and closed positions.
- the interaction of the inner rim 150 and inside retainer 68 and outer rim 152 and outside retainer 66 holds the cover assembly and lid down on top of the housing 32 .
- a bottom cover 158 attached to the housing 32 has a button recess 164 around the actuation button 146 , so that the actuation button 146 does not project beyond the bottom surface of the cover 158 .
- An impeller 162 within the mixing chamber 120 is supported on the shaft of an electric motor 160 behind the mixing chamber 120 in the housing 32 .
- the motor 160 is wired to batteries 168 and the pressure switch 170 .
- a battery indicator LED 174 and a status indicator LED 176 are positioned in the housing 32 , above the pressure switch 170 .
- the disk 42 includes a blister foil ring 190 , preferably a metal or aluminum foil having generally conical blisters formed in it.
- the blister foil ring 190 and a foil seal ring 192 are adhered or bonded onto a carrier disk 194 .
- the carrier disk 194 has tabs 196 suspended within tab slots 198 by bridges 200 .
- Each blister 44 on the blister foil ring 190 is aligned over a tab 196 .
- the bridges 200 hold the tabs 196 in position, but allow the tab to pivot about the bridges, with nominal torque.
- powdered drug 202 is sealed within the blisters 44 .
- the carrier disk 194 is preferably plastic.
- the tab supports 200 are small enough to support the tabs 196 , but also to allow the tab to pivot under force of the post of the actuation button.
- a disk 42 is first loaded into the inhaler 30 by sliding the cover assembly 40 from the closed position shown in FIG. 1 to the open position shown in FIG. 2. In this position, the lid 38 and cover assembly 40 are still held down on top of the housing 32 by the interaction of the outside retainer 66 and inside retainer 68 on the housing outer rim 152 and inner rim 150 . The side wall 56 of the enclosure 48 is lifted slightly away from the housing 32 , to a allow it to pass over the lid stop 46 . As this occurs, the retainers 66 and 68 move off of and release from the inner and outer rims 150 and 152 . The cover assembly 40 and lid 38 are then pivoted upwardly about the hinge 36 , to open up the inhaler 30 , as shown in FIG. 6, for placement or replacement of a disk 42 .
- a disk 42 is placed over the center post 140 over the housing top surface 138 with the blisters 44 on top.
- the lid 38 and cover assembly 40 are pivoted back about the hinge 36 , from the position shown in FIG. 6, to the position shown in FIG. 2.
- the inhaler 30 is then ready for use.
- the rachet posts 142 on the housing top surface 138 project slightly into the open ends 203 of the tab slots 198 .
- the disk 42 is accordingly oriented so that a blister 44 will be aligned over the staging chamber 124 .
- the rachet posts 142 also prevent the disk 42 from moving in reverse (i.e., clockwise in FIG. 6).
- the actuation button 146 With the inhaler 30 preferably held upright, the actuation button 146 is pushed up. As shown in FIGS. 11, 12 and 19 , the upward movement of the post 148 on the actuation button 146 first pivots the tab 196 on the blister 44 over the staging chamber 124 . The tab pivots on the bridges 200 . As this occurs, the foil seal ring 192 sealing the blister 44 on the bottom shears away opening the blister and allowing the powdered drug 202 to fall into the staging chamber 124 .
- the patient places the mouthpiece 34 into the mouth and inhales.
- the inhalation draws air from outside of the housing through the inlet duct 126 , around and under the crescent barrier 128 and into the staging chamber 124 .
- Air and powdered drug 202 move through the duct 122 and into the mixing chamber 120 .
- the reduced air pressure at the mouthpiece 136 is detected by the pressure switch 170 via the tube 172 extending to the pressure port 132 .
- the switch 170 turns on the motor 160 , spinning the impeller 162 within the mixing chamber 120 .
- the air and drug is mixed in the mixing chamber 120 , as further described in U.S. Pat. Nos. 5,327,883, and 5,577,497, incorporated herein by reference.
- the impeller is already spinning at high speed when the drug enters the mixing chamber, the air/drug mixing and deagglomeration are enhanced.
- the cover assembly 40 is moved from the position shown in FIG. 2, to the position shown in FIG. 1, to cover the mouthpiece 34 .
- the arm wedge 96 on the spring arm 86 is released from the lifter 102 .
- This allows the spring arm 86 to flex downwardly with the tab 88 engaging into the opened end 202 of a tab slot 198 , approximately at position A as shown in FIGS. 3 and 6.
- the tab 88 on the spring arm 86 advances the disk 42 to the next blister 44 (moving the disk 42 counter-clockwise in FIG. 3).
- the advancing movement, from engagement of the tab 88 to the disk 42 , until the end of movement, is about 22°.
- the disk 42 rides up and over the angled top surfaces of the rachet posts 142 and then settles back down onto the housing surface 138 with the rachet posts 142 engaged into the next set of opened ends 203 of the tab slots 198 .
- the next blister 44 on the disk 42 is positioned for delivery and inhalation, as described above.
- the disk 42 does not move, as the spring arm 86 is lifted up and out from engagement with the disk by the interaction of the lifter 102 on the lid 38 and the arm wedge 96 on the spring arm 86 .
- each blister 44 on the disk 42 can be sequentially accessed, until all of the blisters are used.
- the ramp 80 on the cover plate 50 rides over the top of the post 148 , the push it down, resetting the actuation button 146 for the next dose, as shown in FIGS. 15 - 17 .
- the guide wall 82 which ramps upwardly from the lever 74 , pushes down on the pivoted tab 196 from the blister delivered.
- the tab 196 is accordingly pushed back down into the plane of the disk 42 , so that the disk can be advanced without interference.
- the rachet posts 142 prevent the disk 42 from moving in reverse (clockwise in FIG. 3) at anytime.
Abstract
A drug powder inhaler has a cover plate pivotably attached to a lid on an inhaler housing. A lever is pivotably attached to the cover plate. A blister pack disk is rotatably mounted on the housing under the cover plate. A powder duct in the housing extends from a staging chamber underneath one end of the lever to an aerosolizing chamber. An actuator in the housing is pressed to shear open a blister on the blister pack disk and thereby deliver the drug dose contents of the blister into the staging chamber. A switch senses pressure in the mouthpiece and switches on a motor spinning an impeller within the aerosolizing chamber, when inhalation is detected.
Description
- This application is a continuation of U.S. patent application Ser. No. 09/351,895, filed Jul. 13, 1999, and now pending, which is a continuation-in-part of application Ser. No. 08/428,960, filed Apr. 24, 1995 and now U.S. Pat. No. 5,622,166, and incorporated herein by reference.
- The field of the invention is inhalers. More specifically, the invention relates to inhalers for delivering drugs in a solid finely divided dry powder or fluid form.
- Inhalers are used to deliver drugs into a patient's lungs. Typically, an inhaler contains or provides a mixture of drugs and air or propellants. The mixture is delivered via the patient inhaling from a mouthpiece on the inhaler, for treatment of various conditions, for example, bronchial asthma. However, delivery of drugs via inhalation can be used for many other treatments, including those unrelated to lung condition.
- One well known inhaler, the Diskhaler, described in U.S. with each successive dose. However, while the device described in U.S. Pat. No. 4,627,432 has met with varying degrees of success, disadvantages remain in indexing or advancing a blister disk within an inhaler, with opening the blisters to access the drug contents, with reliably providing intended dosages, and in other areas.
- Accordingly, it is an object of the invention to provide an improved inhaler.
- To these ends, the present inhaler preferably includes a cover plate pivotably attached to a lid on an inhaler housing. A blister pack disk is rotatably mounted on the housing under the cover plate, and is movable in a single forward direction. An actuator in the housing is most desirably aligned with a lever on the cover plate. The patient pushes the actuator which shears open a blister on the disk and then causes the lever to crush the blister, to deliver the drug powder contents of the blister into a duct within the housing, for subsequent inhalation by the patient.
- Other and further objects will appear hereinafter.
- In the drawings, wherein similar reference characters denote similar elements throughout the several views:
- FIG. 1 is perspective view of the present inhaler with the mouthpiece covered by the cover assembly;
- FIG. 2 is a perspective view thereof with the mouthpiece uncovered;
- FIG. 3 is a plan view of the inhaler as shown in FIG. 1;
- FIG. 4 is a plan view of the inhaler as shown in FIG. 2;
- FIG. 5 is an exploded perspective view of the inhaler of FIGS. 1 and 2;
- FIG. 6 is an plan view of the inhaler of FIGS. 1 and 2 with the lid open;
- FIG. 7 is a partial section view taken along line7-7 of FIG. 6;
- FIG. 8 is an enlarged top and front perspective view of the cover assembly on the inhalers of FIGS. 1 and 2;
- FIG. 9 is a bottom and rear perspective view of the cover assembly of FIG. 8;
- FIG. 10 is an enlarged view of features shown in FIG. 9;
- FIG. 11 is a partial section view taken along line11-11 of FIG. 5;
- FIG. 12 is similar view showing positions of various components during use of the device;
- FIG. 13 is a partial section view taken along line13-13 of FIG. 3;
- FIG. 14 is a partial section view taken along line14-14 of FIG. 4;
- FIGS. 15, 16 and17 are partial section view fragments illustrating movement of components within the device;
- FIG. 18 is a section view taken along line18-18 of FIG. 5;
- FIG. 19 is a similar view thereof with various components omitted for drawing clarity, and showing positions of components during use;
- FIG. 20 is an exploded perspective view of a blister disk for use with the inhaler shown in FIGS. 1 and 2;
- FIG. 21 is a partial plan view thereof; and
- FIG. 22 is a section view taken along line22-22 of FIG. 21.
- Turning now in detail to the drawings, as shown in FIGS.1-4, a dry powder inhaler includes a
housing 32 having alid 38 attached to the housing with ahinge 36. Thelid 38 is preferably a transparent material, e.g., clear plastic. Aremovable mouthpiece 34 is provided on one side of thehousing 32. Asliding cover assembly 40 may be pivoted on thelid 38 from a closed position covering themouthpiece 34, as shown in FIGS. 1 and 3, to an opened position exposing themouthpiece 34, as shown in FIGS. 2 and 4. As best shown in FIGS. 3 and 4 (looking down through the transparent lid 38), adisk 42 having a plurality of radially spaced apartblisters 44 is generally centered on top of thehousing 32 on acenter post 140 extending upwardly from thehousing 32. Alid stop 46 on thehousing 32 limits sliding movement of thecover assembly 40 in the opened position. - Turning momentarily to FIGS. 8 and 9, the sliding
cover assembly 40 includes anenclosure 48 having a frontcurved wall 54, aside wall 56, atop wall 58 and a bottom wall 60. Arim 62 extends upwardly and radially inwardly on thetop wall 58. - Referring now to FIG. 9, a glide block64 and an outside retainer 66 extend downwardly and inwardly on the underside of the
top wall 58. A generallyflat cover plate 50 is preferably integrally formed with theenclosure 48, with thecover plate 50 and enclosure comprising thecover assembly 40. Aninside retainer 68 on thecover plate 50 extends radially outwardly. Alever 74 is pivotably supported on alever pin 76 held in place bylever blocks 72 on the underside of thecover plate 50. Thelever 74 can pivot through a lever opening 78 in thecover plate 50, as best shown in FIG. 8. Aramp 80 and aguide wall 82 project downwardly from thecover plate 50, adjacent to thelever 74, as shown in FIG. 9. Theentire cover assembly 40, which includes theenclosure 48 andcover plate 50 is pivotably attached to thelid 38, with thelid post 52 extending through acenter hub 84 on thecover plate 50.Clearance holes 70 through thecover plate 50 on either side of thelever opening 78 allow the cover plate to sit on top of the blister disk, as shown in FIG. 18, without excessive vertical interference. - Referring to FIGS. 8, 9 and10, a
spring arm 86 having a downwardly projectingend tab 88 is attached to or integral with thecover plate 50. As shown in FIG. 13, thespring arm 86 includes anarm wedge 96 at its free end, alongside thetab 88. As shown in FIG. 10, anarm lifter 102 extends downwardly from thelid 38. Anouter slot 94 through thecover plate 50 overlies thespring arm 86. Aninner slot 92 adjoining theouter slot 94 through thecover plate 50 provides clearance for thearm lifter 102, and allows thecover assembly 40 to rotate (preferably about 90°). Thearm lifter 102 includes an internal ramp, and is dimensioned to engage thearm wedge 96, and lift thearm 86 up towards thelid 38, as thearm wedge 96 moves into full engagement with thelifter 102. - Turning now to FIG. 5, the
housing 32 includes a mixingchamber 120, and astaging chamber 124 connected to the mixingchamber 120 via aduct 122. Referring now also to FIGS. 6 and 7, aninlet duct 126 extends from one side of thehousing 32 to thestaging chamber 124 via aduct recess 130. Acrescent barrier 128 around the top of thestaging chamber 124 creates an indirect air flow path from outside of the housing, through theinlet duct 126 and into thestaging chamber 124. - In a first embodiment of the present invention, referring once again to FIG. 5, a pressure port or opening132 in the
housing 32 alongside the mixingchamber 120 connects to a pressure switch 170 via atube 172. The pressure port aligns with a mouthpiece port 135 leading into the central opening of the mouthpiece. This provides a continuous duct from the mouthpiece opening to the pressure switch. Themouthpiece 34 or analternative embodiment mouthpiece 136 is secured to thehousing 32 with ahook 134. The mouthpiece is removable by twisting or rotating the mouthpiece, to disengage thehook 134, and then by pulling it off. Rachet posts 142 having angled top surfaces project slightly above the flattop surface 138 of thehousing 32. Anactuation button 146 has apost 148 extending entirely through apost opening 144 in thehousing 32. - Referring momentarily to FIG. 18, a
detent 145 on the housing engages and holds thepost 148 in the up position (driving the lever to crush a blister), until the disk is advanced to the next blister. At the front of the housing, behind the mixingchamber 120, is an inwardly projecting housing inner rim 150, and an outwardly projecting housingouter rim 152. Theouter rim 152 is engaged by the outside retainer 66, and the inner rim is engaged by theinside retainer 68, as thecover assembly 40 is moved between opened and closed positions. The interaction of the inner rim 150 and insideretainer 68 andouter rim 152 and outside retainer 66, holds the cover assembly and lid down on top of thehousing 32. - Referring still to FIG. 5, a
bottom cover 158 attached to thehousing 32 has abutton recess 164 around theactuation button 146, so that theactuation button 146 does not project beyond the bottom surface of thecover 158. Animpeller 162 within the mixingchamber 120 is supported on the shaft of anelectric motor 160 behind the mixingchamber 120 in thehousing 32. Themotor 160 is wired tobatteries 168 and the pressure switch 170. Abattery indicator LED 174 and astatus indicator LED 176 are positioned in thehousing 32, above the pressure switch 170. - Turning now to FIGS.20-22, the
disk 42 includes ablister foil ring 190, preferably a metal or aluminum foil having generally conical blisters formed in it. Theblister foil ring 190 and afoil seal ring 192 are adhered or bonded onto acarrier disk 194. As shown in FIG. 21, thecarrier disk 194 hastabs 196 suspended withintab slots 198 bybridges 200. Eachblister 44 on theblister foil ring 190 is aligned over atab 196. Thebridges 200 hold thetabs 196 in position, but allow the tab to pivot about the bridges, with nominal torque. As shown in FIG. 22,powdered drug 202 is sealed within theblisters 44. Thecarrier disk 194 is preferably plastic. The tab supports 200 are small enough to support thetabs 196, but also to allow the tab to pivot under force of the post of the actuation button. - In use, a
disk 42 is first loaded into theinhaler 30 by sliding thecover assembly 40 from the closed position shown in FIG. 1 to the open position shown in FIG. 2. In this position, thelid 38 and coverassembly 40 are still held down on top of thehousing 32 by the interaction of the outside retainer 66 and insideretainer 68 on the housingouter rim 152 and inner rim 150. Theside wall 56 of theenclosure 48 is lifted slightly away from thehousing 32, to a allow it to pass over thelid stop 46. As this occurs, theretainers 66 and 68 move off of and release from the inner andouter rims 150 and 152. Thecover assembly 40 andlid 38 are then pivoted upwardly about thehinge 36, to open up theinhaler 30, as shown in FIG. 6, for placement or replacement of adisk 42. - A
disk 42 is placed over thecenter post 140 over thehousing top surface 138 with theblisters 44 on top. Thelid 38 and coverassembly 40 are pivoted back about thehinge 36, from the position shown in FIG. 6, to the position shown in FIG. 2. Theinhaler 30 is then ready for use. - The rachet posts142 on the
housing top surface 138 project slightly into the open ends 203 of thetab slots 198. Thedisk 42 is accordingly oriented so that ablister 44 will be aligned over the stagingchamber 124. Therachet posts 142 also prevent thedisk 42 from moving in reverse (i.e., clockwise in FIG. 6). - With the
lid 38 closed, but with thecover assembly 40 opened (as shown in FIG. 2), the inner end of thelever 74 is aligned over the top of thepost 148. The outer end of thelever 74 is aligned over the top of ablister 44, and over the stagingchamber 124. - With the
inhaler 30 preferably held upright, theactuation button 146 is pushed up. As shown in FIGS. 11, 12 and 19, the upward movement of thepost 148 on theactuation button 146 first pivots thetab 196 on theblister 44 over the stagingchamber 124. The tab pivots on thebridges 200. As this occurs, thefoil seal ring 192 sealing theblister 44 on the bottom shears away opening the blister and allowing thepowdered drug 202 to fall into thestaging chamber 124. - As upward movement of the
post 148 continues, the post pivots thelever 74 causing the outer end of the lever to crush theblister 44 down, to release any residual powder into thestaging chamber 124. - With one dose of the powdered drug now delivered from a sealed
blister 44 into thestaging chamber 124, the patient places themouthpiece 34 into the mouth and inhales. The inhalation draws air from outside of the housing through theinlet duct 126, around and under thecrescent barrier 128 and into thestaging chamber 124. Air andpowdered drug 202 move through theduct 122 and into the mixingchamber 120. At the same time, upon inhalation, the reduced air pressure at themouthpiece 136 is detected by the pressure switch 170 via thetube 172 extending to thepressure port 132. The switch 170 turns on themotor 160, spinning theimpeller 162 within the mixingchamber 120. The air and drug is mixed in the mixingchamber 120, as further described in U.S. Pat. Nos. 5,327,883, and 5,577,497, incorporated herein by reference. As the impeller is already spinning at high speed when the drug enters the mixing chamber, the air/drug mixing and deagglomeration are enhanced. - The patient inhales on the mouthpiece drawing in the air/drug mixture from the mixing
chamber 120 via holes 125 in the rear wall of the mouthpiece 34 (which rear wall also forms the front wall of the mixing chamber 120). - To prepare for delivery of the next dose, the
cover assembly 40 is moved from the position shown in FIG. 2, to the position shown in FIG. 1, to cover themouthpiece 34. As this closing movement of thecover assembly 40 occurs, thearm wedge 96 on thespring arm 86 is released from thelifter 102. This allows thespring arm 86 to flex downwardly with thetab 88 engaging into the openedend 202 of atab slot 198, approximately at position A as shown in FIGS. 3 and 6. With the continued closing motion of thecover assembly 40 to the position shown in FIG. 3, thetab 88 on thespring arm 86 advances thedisk 42 to the next blister 44 (moving thedisk 42 counter-clockwise in FIG. 3). For a disk having 16 blisters, the advancing movement, from engagement of thetab 88 to thedisk 42, until the end of movement, is about 22°. As thedisk 42 is advanced by thespring arm 86 on theclosing cover assembly 40, thedisk 42 rides up and over the angled top surfaces of therachet posts 142 and then settles back down onto thehousing surface 138 with therachet posts 142 engaged into the next set of opened ends 203 of thetab slots 198. In this manner, thenext blister 44 on thedisk 42 is positioned for delivery and inhalation, as described above. When thecover assembly 40 is reopened, to the position shown in FIG. 4, thedisk 42 does not move, as thespring arm 86 is lifted up and out from engagement with the disk by the interaction of thelifter 102 on thelid 38 and thearm wedge 96 on thespring arm 86. Through this repeated motion of opening and closing thecover assembly 40, eachblister 44 on thedisk 42 can be sequentially accessed, until all of the blisters are used. - As the
cover assembly 40 is closed, theramp 80 on thecover plate 50 rides over the top of thepost 148, the push it down, resetting theactuation button 146 for the next dose, as shown in FIGS. 15-17. Simultaneously, theguide wall 82, which ramps upwardly from thelever 74, pushes down on the pivotedtab 196 from the blister delivered. Thetab 196 is accordingly pushed back down into the plane of thedisk 42, so that the disk can be advanced without interference. Therachet posts 142 prevent thedisk 42 from moving in reverse (clockwise in FIG. 3) at anytime. - Accordingly, a novel inhaler is described and shown with various advantages over the prior art design. The above-described inhaler may contain various changes and modifications, including various substitutions and equivalents, without departing from the spirit and scope of the present invention.
Claims (18)
1. An inhaler comprising:
a housing;
a staging chamber in the housing, with the staging chamber having an open top, to allow a dose of a dry powder pharmaceutical to move via gravity into the staging chamber from a dose carrier above the staging chamber, and with the staging chamber having a substantially closed bottom end to allow the staging chamber to temporarily hold the dose of dry powder;
a mixing chamber in the housing spaced apart from the staging chamber; and
an enclosed continuous duct extending from the staging chamber to the mixing chamber.
2. The inhaler of claim 1 further comprising an inlet extending into the housing to the staging chamber.
3. The inhaler of claim 1 further comprising a barrier between the staging chamber and the inlet.
4. The inhaler of claim 1 further comprising means for opening the dose carrier aligned above the staging chamber.
5. The inhaler of claim 1 wherein the enclosed duct extends substantially horizontally in the housing.
6. The inhaler of claim 1 wherein the duct and the mixing chamber have round cross sections, and the diameter of mixing chamber is greater than the diameter of the duct.
7. An inhaler comprising:
a housing;
an air flow path extending through the housing and comprising:
an inlet extending into the housing;
a staging chamber within the housing with the inlet joining into the staging chamber;
a mixing chamber within the housing;
a duct in the housing having a first end connecting into the staging chamber and having a second end connecting into the mixing chamber.
8. The inhaler of claim 7 further comprising a mouthpiece forming a wall of the mixing chamber.
9. The inhaler of claim 7 with the mixing chamber having a circumferential wall between flat first and second walls, and wherein the duct connects into the mixing chamber through the first flat wall.
10. The inhaler of claim 7 wherein the staging chamber has an open top for receiving a dose of power via gravity.
11. The inhaler of claim 9 wherein the circumferential wall has a diameter greater than the diameter of the duct.
12. The inhaler of claim 7 wherein the staging chamber has a closed off bottom surface and an open top end.
13. The inhaler of claim 12 wherein the duct connects into the staging chamber adjacent to the closed off bottom surface.
14. The inhaler of claim 7 further including a mouthpiece connecting to the mixing chamber and wherein the duct provides the only connection between the staging chamber and the mixing chamber, such that all air entering into the mixing chamber via the duct, upon inhalation on the mouthpiece by a user of the inhaler, comes from the staging chamber.
15. The inhaler of claim 7 wherein the duct has a round cross section.
16. The inhaler of claim 15 wherein the duct has a length greater than its diameter.
17. The inhaler of claim 7 with the housing having a flat top surface and the duct extends in a direction parallel to the flat top surface.
18. The inhaler of claim 7 wherein the duct is longer than the inlet.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/007,617 US20020040713A1 (en) | 1995-04-24 | 2001-11-07 | Dry powder inhaler |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/428,960 US5622166A (en) | 1995-04-24 | 1995-04-24 | Dry powder inhaler delivery system |
US08/681,103 US5921237A (en) | 1995-04-24 | 1996-07-22 | Dry powder inhaler |
US09/351,895 US6328034B1 (en) | 1996-07-22 | 1999-07-13 | Dry powder inhaler |
US10/007,617 US20020040713A1 (en) | 1995-04-24 | 2001-11-07 | Dry powder inhaler |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/351,895 Continuation US6328034B1 (en) | 1995-04-24 | 1999-07-13 | Dry powder inhaler |
Publications (1)
Publication Number | Publication Date |
---|---|
US20020040713A1 true US20020040713A1 (en) | 2002-04-11 |
Family
ID=26997298
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/681,103 Expired - Fee Related US5921237A (en) | 1995-04-24 | 1996-07-22 | Dry powder inhaler |
US09/351,895 Expired - Fee Related US6328034B1 (en) | 1995-04-24 | 1999-07-13 | Dry powder inhaler |
US10/007,617 Abandoned US20020040713A1 (en) | 1995-04-24 | 2001-11-07 | Dry powder inhaler |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/681,103 Expired - Fee Related US5921237A (en) | 1995-04-24 | 1996-07-22 | Dry powder inhaler |
US09/351,895 Expired - Fee Related US6328034B1 (en) | 1995-04-24 | 1999-07-13 | Dry powder inhaler |
Country Status (11)
Country | Link |
---|---|
US (3) | US5921237A (en) |
EP (1) | EP0925084A4 (en) |
JP (1) | JP2001507949A (en) |
AU (1) | AU729272B2 (en) |
BR (1) | BR9710880A (en) |
CZ (1) | CZ18999A3 (en) |
HU (1) | HUP9903819A3 (en) |
IL (1) | IL128030A0 (en) |
NO (1) | NO990272L (en) |
NZ (2) | NZ505722A (en) |
WO (1) | WO1998003217A1 (en) |
Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040118399A1 (en) * | 2002-12-18 | 2004-06-24 | Elan Pharmaceutical Technologies | Unit dose dry powder inhaler |
US20050126562A1 (en) * | 2003-12-15 | 2005-06-16 | Alexza Molecular Delivery Corporation | Treatment of breakthrough pain by drug aerosol inhalation |
US20070154407A1 (en) * | 2005-12-01 | 2007-07-05 | Boehringer Ingelheim International Gmbh | Inhaler and store for a dry medicament formulation and related methods and use thereof |
US20070221218A1 (en) * | 2003-10-27 | 2007-09-27 | Warden Jeffrey A | Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods |
US20070267015A1 (en) * | 2006-05-18 | 2007-11-22 | Boehringer Ingelheim International Gmbh | Atomizer |
US20070272235A1 (en) * | 2004-02-19 | 2007-11-29 | Akihiko Miyamoto | Inhaler Aid With Reed for Minute Powdery Curative Medicine |
US20080041368A1 (en) * | 2004-08-16 | 2008-02-21 | Glaxo Group Limited | Medicament Dispenser |
US20080196718A1 (en) * | 2005-07-28 | 2008-08-21 | Glaxo Group Limited | Medicament Dispenser |
EP2082772A1 (en) * | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
US7617822B2 (en) | 2003-06-16 | 2009-11-17 | Rijksuniversiteit Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
US20100059052A1 (en) * | 2006-11-15 | 2010-03-11 | Glaxo Group Limited | Sheet driver for use in a drug dispenser |
US20100078022A1 (en) * | 2008-09-26 | 2010-04-01 | Rachel Striebig | Inhalers with airway disks having discrete airway channels and related disks and methods |
USD635246S1 (en) | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
US20110162648A1 (en) * | 2008-09-26 | 2011-07-07 | Ruckdeschel Thomas W | Inhaler mechanisms with radially biased piercers and related methods |
US20110174306A1 (en) * | 2008-09-30 | 2011-07-21 | David Harris | Dry Powder Inhalers with Multi-Facet Surface Deagglomeration Chambers and Related Devices and Methods |
US20110186047A1 (en) * | 2008-10-01 | 2011-08-04 | Scott Alexander Lewis | Dry Powder Inhalers with Rotating Piercing Mechanisms and Related Devices and Methods |
US8161968B2 (en) | 2003-07-24 | 2012-04-24 | Glaxo Group Limited | Medicament dispenser |
US8381721B2 (en) | 2008-09-26 | 2013-02-26 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
WO2014004256A1 (en) * | 2012-06-25 | 2014-01-03 | Respira Therapeutics, Inc. | Powder dispersion devices and methods |
US8997737B2 (en) | 2003-10-17 | 2015-04-07 | Vectura Delivery Devices Limited | Inhaler |
US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
USD852408S1 (en) | 2016-02-08 | 2019-06-25 | Nicoventures Holdings Limited | Electronic cigarette |
US11040156B2 (en) | 2015-07-20 | 2021-06-22 | Pearl Therapeutics, Inc. | Aerosol delivery systems |
US11123501B2 (en) | 2016-03-24 | 2021-09-21 | Nicoventures Holdings Limited | Electronic vapor provision system |
US11213638B2 (en) | 2016-03-24 | 2022-01-04 | Nicoventures Trading Limited | Vapor provision system |
US11241043B2 (en) | 2016-03-24 | 2022-02-08 | Nicoventures Trading Limited | Vapor provision apparatus |
US11452826B2 (en) | 2016-03-24 | 2022-09-27 | Nicoventures Trading Limited | Mechanical connector for electronic vapor provision system |
US11471623B2 (en) | 2012-02-21 | 2022-10-18 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
US11524823B2 (en) | 2016-07-22 | 2022-12-13 | Nicoventures Trading Limited | Case for a vapor provision device |
Families Citing this family (139)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040237961A1 (en) * | 1995-06-08 | 2004-12-02 | Snow John Medlin | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US6672304B1 (en) | 1995-06-08 | 2004-01-06 | Innovative Devices, Llc | Inhalation actuated device for use with metered dose inhalers (MDIs) |
US6470884B2 (en) | 1996-01-29 | 2002-10-29 | Aventis Pharma Limited | Capsule opening arrangement for use in a powder inhaler |
US6237590B1 (en) * | 1997-09-18 | 2001-05-29 | Delsys Pharmaceutical Corporation | Dry powder delivery system apparatus |
US6237591B1 (en) | 1998-11-02 | 2001-05-29 | Dura Pharmaceuticals, Inc. | Turbine dry powder inhaler |
US6655379B2 (en) | 1998-03-16 | 2003-12-02 | Nektar Therapeutics | Aerosolized active agent delivery |
SE9801114D0 (en) * | 1998-03-30 | 1998-03-30 | Astra Ab | Inhalation device |
DE19831525A1 (en) * | 1998-07-14 | 2000-01-20 | Pfeiffer Erich Gmbh & Co Kg | Media Donor |
GB9820937D0 (en) | 1998-09-26 | 1998-11-18 | Glaxo Group Ltd | Inhalation device |
GB9820886D0 (en) * | 1998-09-26 | 1998-11-18 | Glaxo Group Ltd | Inhalation device |
UA73924C2 (en) * | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
CA2725731A1 (en) * | 1999-06-05 | 2000-12-14 | Innovata Biomed Limited | Delivery system |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6606992B1 (en) * | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
US7464706B2 (en) * | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
GB9920839D0 (en) * | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
WO2001034234A1 (en) * | 1999-11-11 | 2001-05-17 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
GB9930602D0 (en) * | 1999-12-24 | 2000-02-16 | Glaxo Group Ltd | Inhalation device |
US6651655B1 (en) | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
US7069929B2 (en) * | 2000-02-01 | 2006-07-04 | Quadrant Technologies Limited | Dry powder inhaler |
WO2001078817A1 (en) * | 2000-02-25 | 2001-10-25 | Dura Pharmaceuticals, Inc. | Dosing system for a dry powder inhaler |
ES2305057T3 (en) | 2000-02-28 | 2008-11-01 | Pharmakodex Limited | DEVICE FOR THE ADMINISTRATION OF ORAL PHARMACES. |
AU2001250901A1 (en) * | 2000-03-27 | 2001-10-08 | Dura Pharmaceuticals, Inc. | Containers for individual doses of an inhalable pharmaceutical |
US6948494B1 (en) * | 2000-05-10 | 2005-09-27 | Innovative Devices, Llc. | Medicament container with same side airflow inlet and outlet and method of use |
GB0015034D0 (en) * | 2000-06-21 | 2000-08-09 | Glaxo Group Ltd | Inhalation device |
US7080644B2 (en) * | 2000-06-28 | 2006-07-25 | Microdose Technologies, Inc. | Packaging and delivery of pharmaceuticals and drugs |
GB0015801D0 (en) * | 2000-06-28 | 2000-08-16 | Innovata Biomed Ltd | Cover |
GB0019715D0 (en) * | 2000-08-10 | 2000-09-27 | Pa Consulting Services | Device for delivering physiologically active agent in powdered form |
AU2001283546A1 (en) | 2000-08-14 | 2002-02-25 | Advanced Inhalation Research, Inc. | Inhalation device and method |
WO2002013886A2 (en) * | 2000-08-15 | 2002-02-21 | University Of Kentucky Research Foundation | Programmable multi-dose intranasal drug delivery device |
GB0026647D0 (en) | 2000-10-31 | 2000-12-13 | Glaxo Group Ltd | Medicament dispenser |
JP5154732B2 (en) * | 2001-02-06 | 2013-02-27 | イノバータ・バイオメッド・リミテッド | Drug |
US6766799B2 (en) * | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
ATE452617T1 (en) * | 2001-04-19 | 2010-01-15 | Technology Innovation Ltd | MEDICINE CONTAINERS |
GB0113881D0 (en) | 2001-06-07 | 2001-08-01 | Innovate Biomed Ltd | Foil cutting system |
US6681768B2 (en) | 2001-06-22 | 2004-01-27 | Sofotec Gmbh & Co. Kg | Powder formulation disintegrating system and method for dry powder inhalers |
CN1313171C (en) | 2001-09-19 | 2007-05-02 | 埃德文特药物有限公司 | An inhaler |
GB0128148D0 (en) * | 2001-11-23 | 2002-01-16 | Innovata Biomed Ltd | Assembly |
GB0130055D0 (en) * | 2001-12-14 | 2002-02-06 | Technology Innovation Ltd | Medicament packaging |
EP1494732B1 (en) | 2002-03-20 | 2008-01-30 | MannKind Corporation | Inhalation apparatus |
US7118010B2 (en) | 2002-05-10 | 2006-10-10 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for dispensing and /or evaluating dry powders |
DE60330776D1 (en) * | 2002-05-10 | 2010-02-11 | Oriel Therapeutics Inc | DRY POWDER INHALER WITH A PIEZOELECTRIC POLYMER DRIVEN DISPENSER AND ASSOCIATED BLISTER PACKING WITH A PIEZOELECTRIC POLYMER MATERIAL |
US6985798B2 (en) | 2002-05-10 | 2006-01-10 | Oriel Therapeutics, Inc. | Dry powder dose filling systems and related methods |
US7677411B2 (en) * | 2002-05-10 | 2010-03-16 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for processing, dispensing and/or evaluatingl dry powders |
US6889690B2 (en) * | 2002-05-10 | 2005-05-10 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister devices, and associated methods of dispensing dry powder substances and fabricating blister packages |
US7185651B2 (en) * | 2002-06-18 | 2007-03-06 | Nektar Therapeutics | Flow regulator for aerosol drug delivery and methods |
EP1535349B1 (en) * | 2002-06-27 | 2014-06-25 | Oriel Therapeutics, Inc. | Apparatus, systems and related methods for processing, dispensing and/or evaluating non-pharmaceutical dry powders |
CA2506866A1 (en) * | 2002-11-20 | 2004-06-03 | Sun Pharmaceutical Industries Limited | Dry powder inhaler |
FR2849386B1 (en) | 2002-12-27 | 2005-03-18 | Bertin Technologies Sa | INHALATION DEVICE FOR DRY POWDER |
GB0303870D0 (en) * | 2003-02-20 | 2003-03-26 | Norton Healthcare Ltd | Pre-metered dose magazine for breath-actuated dry powder inhaler |
EP1603810B1 (en) * | 2003-03-15 | 2010-08-11 | Brin Tech International Limited | Medicament package |
GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
WO2005041848A2 (en) * | 2003-10-27 | 2005-05-12 | Oriel Therapeutics, Inc. | Dry powder drug containment system packages with tabs, inhalers and associated methods |
US7451761B2 (en) * | 2003-10-27 | 2008-11-18 | Oriel Therapeutics, Inc. | Dry powder inhalers, related blister package indexing and opening mechanisms, and associated methods of dispensing dry powder substances |
US7377277B2 (en) * | 2003-10-27 | 2008-05-27 | Oriel Therapeutics, Inc. | Blister packages with frames and associated methods of fabricating dry powder drug containment systems |
JP2007533387A (en) * | 2004-04-21 | 2007-11-22 | イノベータ バイオメド リミテッド | Inhaler |
US7861712B2 (en) * | 2004-04-23 | 2011-01-04 | Manta Product Development | Sealed capsule including an integrated puncturing mechanism |
GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
DE102004022796A1 (en) * | 2004-05-08 | 2005-12-01 | Arndt Muhle | Inhaler unit takes the form of a hollow column which is provided with a mouthpiece, and is loaded with an inhalate in separate packages with removable lids |
US20050263153A1 (en) * | 2004-05-28 | 2005-12-01 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
US7556035B2 (en) * | 2004-05-28 | 2009-07-07 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
DK1786784T3 (en) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Catalysis of diketopiperazine synthesis |
PL2322180T3 (en) | 2004-08-23 | 2015-10-30 | Mannkind Corp | Diketopiperazine salts for drug delivery |
WO2006037636A2 (en) * | 2004-10-06 | 2006-04-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing powder |
JP2006130143A (en) * | 2004-11-08 | 2006-05-25 | Hitachi Ltd | Inhalation administration device and medicine cartridge |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
PL2486942T3 (en) | 2004-11-24 | 2019-05-31 | Meda Pharmaceuticals Inc | Compositions comprising azelastine and methods of use thereof |
US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
US7694676B2 (en) * | 2005-04-22 | 2010-04-13 | Boehringer Ingelheim Gmbh | Dry powder inhaler |
US8524735B2 (en) | 2005-05-18 | 2013-09-03 | Mpex Pharmaceuticals, Inc. | Aerosolized fluoroquinolones and uses thereof |
PT2594272T (en) | 2005-05-18 | 2018-07-31 | Horizon Orphan Llc | Aerosolized fluoroquinolones and uses thereof |
US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
CN104324366B (en) | 2005-09-14 | 2016-10-05 | 曼金德公司 | Method for preparation of drug based on improving the active agent affinity to crystalline microparticle surfaces |
MX360812B (en) | 2006-02-22 | 2018-11-16 | Mannkind Corp | A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent. |
DE102006014434A1 (en) * | 2006-03-27 | 2007-10-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Packaging for multidose powder inhalers with optimized emptying properties |
US8037880B2 (en) * | 2006-04-07 | 2011-10-18 | The University Of Western Ontario | Dry powder inhaler |
JP5241714B2 (en) | 2006-07-07 | 2013-07-17 | プロテウス デジタル ヘルス, インコーポレイテッド | Smart parenteral delivery system |
US7726223B2 (en) * | 2006-11-14 | 2010-06-01 | Cb Products, Inc. | Apparatus and methods for accessing packaged medicaments |
US20080110453A1 (en) * | 2006-11-15 | 2008-05-15 | Delphi Technologies Inc. | Nebulizer and methods for controlling the nebulizer |
US20080110452A1 (en) * | 2006-11-15 | 2008-05-15 | Delphi Technologies Inc. | Nebulizer and method for controlling an amount of liquid that is atomized by the nebulizer |
US20080156320A1 (en) * | 2007-01-03 | 2008-07-03 | Thomas Low | Ultrasonic nebulizer and method for atomizing liquid |
US20080163610A1 (en) * | 2007-01-05 | 2008-07-10 | Matthew Thomas Baird | Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle |
GB0704928D0 (en) * | 2007-03-14 | 2007-04-25 | Cambridge Consultants | Dry powder inhalers |
US8496002B2 (en) * | 2007-06-12 | 2013-07-30 | Civitas Therapeutics, Inc. | Powder inhaler devices |
US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
CN101795723B (en) | 2007-07-06 | 2013-06-19 | 蒙塔设备有限公司 | Inhalation devices for storing and delivering medicament |
WO2009055733A1 (en) | 2007-10-25 | 2009-04-30 | Proteus Biomedical, Inc. | Fluid transfer port information system |
WO2009067463A1 (en) | 2007-11-19 | 2009-05-28 | Proteus Biomedical, Inc. | Body-associated fluid transport structure evaluation devices |
AU2008341217B2 (en) | 2007-12-20 | 2012-04-12 | Astrazeneca Ab | Dispenser and method for entraining powder in an airflow 537 |
BRPI0906596A2 (en) * | 2008-01-23 | 2015-07-07 | Astrazeneca Ab | Medicine-containing dispenser provided with a display to display markings to a user |
EP2082764A1 (en) | 2008-01-24 | 2009-07-29 | Boehringer Ingelheim International GmbH | Inhaler |
MX371521B (en) * | 2008-03-27 | 2020-01-31 | Mannkind Corp | A dry powder inhalation system. |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
DE202009018480U1 (en) | 2008-06-13 | 2012-01-26 | Mannkind Corp. | Dry powder inhaler and drug delivery system |
MX2010014240A (en) | 2008-06-20 | 2011-03-25 | Mankind Corp | An interactive apparatus and method for real-time profiling of inhalation efforts. |
TWI532497B (en) | 2008-08-11 | 2016-05-11 | 曼凱公司 | Use of ultrarapid acting insulin |
CN105520922A (en) | 2008-10-07 | 2016-04-27 | 拉普特制药有限公司 | Aerosol fluoroquinolone formulations for improved pharmacokinetics |
EP2346509B1 (en) | 2008-10-07 | 2020-05-13 | Horizon Orphan LLC | Inhalation of levofloxacin for reducing lung inflammation |
GB201020130D0 (en) | 2010-11-26 | 2011-01-12 | Vectura Delivery Devices Ltd | Inhaler |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
WO2010083042A1 (en) * | 2009-01-15 | 2010-07-22 | Manta Devices, Llc | Delivery device |
NZ574666A (en) * | 2009-02-05 | 2009-04-30 | Nexus6 Ltd | A medicament inhaler holder that uses optical means to count and display the number of doses used |
US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
FR2946537B1 (en) * | 2009-06-11 | 2012-08-03 | Valois Sas | INHALATION DEVICE FOR POWDER |
KR101875969B1 (en) | 2009-06-12 | 2018-07-06 | 맨카인드 코포레이션 | Diketopiperazine microparticles with defined specific surface areas |
RU2536826C2 (en) | 2009-07-01 | 2014-12-27 | Астразенека Аб | Delivery device and method for increasing powder supply into air flow |
RU2563809C2 (en) | 2009-09-04 | 2015-09-20 | Мпекс Фармасьютикалс, Инк. | Using levofloxacin in aerosol form for treating mucoviscidosis |
CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
WO2011080761A1 (en) | 2009-12-30 | 2011-07-07 | Thirumalai Anadampillai Aparna | An improved dry powder inhaler |
CN104338219B (en) | 2010-01-05 | 2017-10-24 | 微剂量治疗技术公司 | inhalation device and method |
EP2531096A4 (en) | 2010-02-01 | 2013-09-11 | Proteus Digital Health Inc | Two-wrist data gathering system |
US9014779B2 (en) | 2010-02-01 | 2015-04-21 | Proteus Digital Health, Inc. | Data gathering system |
WO2011116293A2 (en) | 2010-03-19 | 2011-09-22 | Manta Devices, Llc | Delivery device and related methods |
RU2571331C1 (en) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Systems and methods for dry powder drug delivery |
US20140000601A1 (en) * | 2010-07-21 | 2014-01-02 | Astrazeneca Ab | Inhaler |
WO2012106382A1 (en) | 2011-01-31 | 2012-08-09 | Genoa Pharmaceuticals, Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
BR122020008875B8 (en) | 2011-04-01 | 2022-12-06 | Mannkind Corp | BLISTER PACKAGING AND METHOD OF MANUFACTURING A BLISTER PACKAGE |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
US11103659B2 (en) | 2011-07-06 | 2021-08-31 | Manta Devices, Llc | Delivery device and related methods |
CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
US9649454B2 (en) | 2012-05-03 | 2017-05-16 | Manta Devices, Llc | Delivery device and related methods |
EA030019B1 (en) * | 2012-05-25 | 2018-06-29 | Арвен Айлак Санайи Ве Тиджарет А.С. | Trigger mechanism for inhaler device |
KR102264177B1 (en) | 2012-07-12 | 2021-06-11 | 맨카인드 코포레이션 | Dry powder drug delivery systems and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
BR112015023168B1 (en) | 2013-03-15 | 2021-08-10 | Mannkind Corporation | COMPOSITION OF 3,6-BIS(N-FUMARYL-4-AMINOBUTYL)-2,5-CRYSTALLINE DICETOPIPERAZINE, METHOD OF PRODUCTION OF 3,6-BIS(N-FUMARYL-4-AMINOBUTYL)-2,5-DICETOPIPERAZINE PARTICLES AND USE OF A CRYSTALLINE DICETOPIPERAZINE COMPOSITION |
CN114848614A (en) | 2013-07-18 | 2022-08-05 | 曼金德公司 | Heat stable dry powder pharmaceutical compositions and methods |
EP3027026A4 (en) | 2013-07-31 | 2017-05-03 | Windward Pharma, Inc. | Aerosol tyrosine kinase inhibitor compounds and uses thereof |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
NZ760541A (en) | 2014-01-10 | 2022-08-26 | Avalyn Pharma Inc | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US11147936B2 (en) | 2014-05-02 | 2021-10-19 | Manta Devices, Llc | Dose delivery device with cover connected to dose chamber seal |
US9895500B2 (en) * | 2014-07-24 | 2018-02-20 | Hcmed Innovations Co., Ltd. | Portable ultrasonic nebulizer and medicine accommodating structure thereof |
TWI566795B (en) * | 2014-07-24 | 2017-01-21 | 心誠鎂行動醫電股份有限公司 | Portable ultrasonic nebulizer and protection structure thereof |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
EP3061501A1 (en) | 2015-02-27 | 2016-08-31 | Rottapharm Ltd. | Composition for the treatment of acne |
EP3117825A1 (en) | 2015-07-16 | 2017-01-18 | Rottapharm S.p.A. | Oral formulation comprising berberine and morus alba extract |
WO2022240897A1 (en) | 2021-05-10 | 2022-11-17 | Sepelo Therapeutics, Llc | Pharmaceutical composition comprising delafloxacin for administration into the lung |
WO2023028364A1 (en) | 2021-08-27 | 2023-03-02 | Sepelo Therapeutics, Llc | Targeted compositions and uses therof |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4307734A (en) * | 1980-06-23 | 1981-12-29 | B & B Inventors & Marketers, Inc. | Snuff dispenser |
US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
GR79615B (en) * | 1982-10-08 | 1984-10-31 | Glaxo Group Ltd | |
GB8314308D0 (en) * | 1983-05-24 | 1983-06-29 | Matburn Holdings Ltd | Medical administration devices |
CH672600A5 (en) * | 1985-07-30 | 1989-12-15 | Glaxo Group Ltd | |
US4971221A (en) * | 1988-11-23 | 1990-11-20 | Aprex Corporation | Drug dispenser having means for detecting dispensing events |
IT1230313B (en) * | 1989-07-07 | 1991-10-18 | Somova Spa | INHALER FOR CAPSULES MEDICATIONS. |
IT1237118B (en) * | 1989-10-27 | 1993-05-18 | Miat Spa | MULTI-DOSE INHALER FOR POWDER DRUGS. |
DK544589D0 (en) * | 1989-11-01 | 1989-11-01 | Novo Nordisk As | MANUALLY OPERATED DEVICE FOR DISPENSING A PRESCRIBED QUANTITY OF A POWDER-SHAPED SUBSTANCE |
US5113855A (en) * | 1990-02-14 | 1992-05-19 | Newhouse Michael T | Powder inhaler |
US5201308A (en) * | 1990-02-14 | 1993-04-13 | Newhouse Michael T | Powder inhaler |
GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
IT1243344B (en) * | 1990-07-16 | 1994-06-10 | Promo Pack Sa | MULTI-DOSE INHALER FOR POWDER MEDICATIONS |
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5327883A (en) * | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
US5469843A (en) * | 1991-11-12 | 1995-11-28 | Minnesota Mining And Manufacturing Company | Inhalation device |
CZ282964B6 (en) * | 1992-10-19 | 1997-11-12 | Dura Pharmaceuticals, Inc. | Apparatus for making aerosol from a pulverized medicament |
HU216405B (en) * | 1993-03-03 | 1999-06-28 | Tenax Corp. | Dry powder inhalator medicament carrier |
US5349947A (en) * | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
CA2172952A1 (en) * | 1993-10-28 | 1995-05-04 | Michael Leonard Mckay | Improvements relating to formation and delivery of an atomised liquid |
CA2555600C (en) * | 1994-09-21 | 2008-01-29 | Nektar Therapeutics | Apparatus and methods for dispersing dry powder medicaments |
US5645051A (en) * | 1995-04-21 | 1997-07-08 | Dura Pharmaceuticals, Inc. | Unit dose dry powder inhaler |
US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
-
1996
- 1996-07-22 US US08/681,103 patent/US5921237A/en not_active Expired - Fee Related
-
1997
- 1997-07-07 NZ NZ505722A patent/NZ505722A/en unknown
- 1997-07-07 BR BR9710880A patent/BR9710880A/en not_active Application Discontinuation
- 1997-07-07 JP JP50694698A patent/JP2001507949A/en active Pending
- 1997-07-07 EP EP97933231A patent/EP0925084A4/en not_active Withdrawn
- 1997-07-07 HU HU9903819A patent/HUP9903819A3/en unknown
- 1997-07-07 CZ CZ99189A patent/CZ18999A3/en unknown
- 1997-07-07 NZ NZ333685A patent/NZ333685A/en unknown
- 1997-07-07 IL IL12803097A patent/IL128030A0/en unknown
- 1997-07-07 AU AU36466/97A patent/AU729272B2/en not_active Ceased
- 1997-07-07 WO PCT/US1997/011440 patent/WO1998003217A1/en not_active Application Discontinuation
-
1999
- 1999-01-21 NO NO990272A patent/NO990272L/en unknown
- 1999-07-13 US US09/351,895 patent/US6328034B1/en not_active Expired - Fee Related
-
2001
- 2001-11-07 US US10/007,617 patent/US20020040713A1/en not_active Abandoned
Cited By (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004054646A1 (en) * | 2002-12-18 | 2004-07-01 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
US6941947B2 (en) | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
US20050252510A1 (en) * | 2002-12-18 | 2005-11-17 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
US20040118399A1 (en) * | 2002-12-18 | 2004-06-24 | Elan Pharmaceutical Technologies | Unit dose dry powder inhaler |
US7617822B2 (en) | 2003-06-16 | 2009-11-17 | Rijksuniversiteit Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
US8161968B2 (en) | 2003-07-24 | 2012-04-24 | Glaxo Group Limited | Medicament dispenser |
US8997737B2 (en) | 2003-10-17 | 2015-04-07 | Vectura Delivery Devices Limited | Inhaler |
US20070221218A1 (en) * | 2003-10-27 | 2007-09-27 | Warden Jeffrey A | Dry Powder Drug Containment System Packages with Tabs, Inhalers and Associated Methods |
US20050126562A1 (en) * | 2003-12-15 | 2005-06-16 | Alexza Molecular Delivery Corporation | Treatment of breakthrough pain by drug aerosol inhalation |
US9016273B2 (en) * | 2004-02-19 | 2015-04-28 | Akihiko Miyamoto | Inhaler aid with reed for minute powdery curative medicine |
US20070272235A1 (en) * | 2004-02-19 | 2007-11-29 | Akihiko Miyamoto | Inhaler Aid With Reed for Minute Powdery Curative Medicine |
US9333310B2 (en) | 2004-08-16 | 2016-05-10 | Glaxo Group Limited | Medicament dispenser |
US20080041368A1 (en) * | 2004-08-16 | 2008-02-21 | Glaxo Group Limited | Medicament Dispenser |
US8201556B2 (en) * | 2004-08-16 | 2012-06-19 | Glaxo Group Limited | Medicament dispenser |
US8746242B2 (en) | 2005-07-28 | 2014-06-10 | Glaxo Group Limited | Medicament dispenser |
US20080196718A1 (en) * | 2005-07-28 | 2008-08-21 | Glaxo Group Limited | Medicament Dispenser |
US20070154407A1 (en) * | 2005-12-01 | 2007-07-05 | Boehringer Ingelheim International Gmbh | Inhaler and store for a dry medicament formulation and related methods and use thereof |
US9463290B2 (en) | 2006-05-18 | 2016-10-11 | Boehringer Ingelheim International Gmbh | Atomizer |
US8813743B2 (en) * | 2006-05-18 | 2014-08-26 | Boehringer Ingelheim International Gmbh | Atomizer |
US20070267015A1 (en) * | 2006-05-18 | 2007-11-22 | Boehringer Ingelheim International Gmbh | Atomizer |
US8776788B2 (en) | 2006-11-15 | 2014-07-15 | Glaxo Group Limited | Sheet driver for use in a drug dispenser |
US20100059052A1 (en) * | 2006-11-15 | 2010-03-11 | Glaxo Group Limited | Sheet driver for use in a drug dispenser |
US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
US20110094510A1 (en) * | 2008-01-24 | 2011-04-28 | Vectura Delivery Devices Limited | Inhaler |
CN101980742A (en) * | 2008-01-24 | 2011-02-23 | 维克多瑞传送设备有限公司 | Inhaler |
EP2082772A1 (en) * | 2008-01-24 | 2009-07-29 | Vectura Delivery Devices Limited | Inhaler |
RU2481129C2 (en) * | 2008-01-24 | 2013-05-10 | Вектура Деливери Дивайсиз Лимитед | Inhaler |
WO2009092770A1 (en) * | 2008-01-24 | 2009-07-30 | Vectura Delivery Devices Limited | Inhaler |
US20110162648A1 (en) * | 2008-09-26 | 2011-07-07 | Ruckdeschel Thomas W | Inhaler mechanisms with radially biased piercers and related methods |
US8550071B2 (en) | 2008-09-26 | 2013-10-08 | Oriel Therapeutics, Inc. | Inhalers with airway disks having discrete airway channels and related disks and methods |
US8985103B2 (en) | 2008-09-26 | 2015-03-24 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members |
US8381721B2 (en) | 2008-09-26 | 2013-02-26 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and related devices and methods |
US8671938B2 (en) | 2008-09-26 | 2014-03-18 | Oriel Therapeutics, Inc. | Inhalers with airway disks having discrete airway channels and related disks and methods |
US9597465B2 (en) | 2008-09-26 | 2017-03-21 | Oriel Therapeutics, Inc. | Methods of operating and fabricating inhalers with airway disks having discrete airway channels |
US9795749B2 (en) | 2008-09-26 | 2017-10-24 | Oriel Therapeutics, Inc. | Dry powder inhalers with dual piercing members and methods of operating same |
US10493222B2 (en) | 2008-09-26 | 2019-12-03 | Oriel Therapeutics, Inc. | Dry powder dose container assemblies and related inhalers |
US20100078022A1 (en) * | 2008-09-26 | 2010-04-01 | Rachel Striebig | Inhalers with airway disks having discrete airway channels and related disks and methods |
US8887722B2 (en) | 2008-09-26 | 2014-11-18 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
US9050427B2 (en) | 2008-09-30 | 2015-06-09 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
US20110174306A1 (en) * | 2008-09-30 | 2011-07-21 | David Harris | Dry Powder Inhalers with Multi-Facet Surface Deagglomeration Chambers and Related Devices and Methods |
US8646446B2 (en) | 2008-10-01 | 2014-02-11 | Oriel Therapeutics, Inc. | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
US20110186047A1 (en) * | 2008-10-01 | 2011-08-04 | Scott Alexander Lewis | Dry Powder Inhalers with Rotating Piercing Mechanisms and Related Devices and Methods |
USD685461S1 (en) | 2010-03-26 | 2013-07-02 | Oriel Therapeutics, Inc. | Dose disk for a dry powder inhaler |
USD745660S1 (en) | 2010-03-26 | 2015-12-15 | Oriel Therapeutics, Inc. | Dry powder inhaler |
USD684684S1 (en) | 2010-03-26 | 2013-06-18 | Oriel Therapeutics, Inc. | Dry powder inhaler |
USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
USD635246S1 (en) | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
USD711528S1 (en) | 2010-03-26 | 2014-08-19 | Oriel Therapeutics, Inc. | Dry powder inhaler |
US10463815B2 (en) | 2012-02-21 | 2019-11-05 | Respira Therapeutics, Inc. | Inhaler to deliver substances for prophylaxis or prevention of disease or injury caused by the inhalation of biological or chemical agents |
US11471623B2 (en) | 2012-02-21 | 2022-10-18 | Respira Therapeutics, Inc. | Powder dispersion methods and devices |
US10441733B2 (en) | 2012-06-25 | 2019-10-15 | Respira Therapeutics, Inc. | Powder dispersion devices and methods |
WO2014004256A1 (en) * | 2012-06-25 | 2014-01-03 | Respira Therapeutics, Inc. | Powder dispersion devices and methods |
US11040156B2 (en) | 2015-07-20 | 2021-06-22 | Pearl Therapeutics, Inc. | Aerosol delivery systems |
USD852408S1 (en) | 2016-02-08 | 2019-06-25 | Nicoventures Holdings Limited | Electronic cigarette |
US11123501B2 (en) | 2016-03-24 | 2021-09-21 | Nicoventures Holdings Limited | Electronic vapor provision system |
US11213638B2 (en) | 2016-03-24 | 2022-01-04 | Nicoventures Trading Limited | Vapor provision system |
US11241043B2 (en) | 2016-03-24 | 2022-02-08 | Nicoventures Trading Limited | Vapor provision apparatus |
US11452826B2 (en) | 2016-03-24 | 2022-09-27 | Nicoventures Trading Limited | Mechanical connector for electronic vapor provision system |
US11524823B2 (en) | 2016-07-22 | 2022-12-13 | Nicoventures Trading Limited | Case for a vapor provision device |
Also Published As
Publication number | Publication date |
---|---|
US6328034B1 (en) | 2001-12-11 |
NZ333685A (en) | 2000-09-29 |
BR9710880A (en) | 1999-08-17 |
EP0925084A1 (en) | 1999-06-30 |
IL128030A0 (en) | 1999-11-30 |
HUP9903819A3 (en) | 2001-02-28 |
AU729272B2 (en) | 2001-02-01 |
WO1998003217A1 (en) | 1998-01-29 |
JP2001507949A (en) | 2001-06-19 |
NZ505722A (en) | 2001-03-30 |
US5921237A (en) | 1999-07-13 |
AU3646697A (en) | 1998-02-10 |
EP0925084A4 (en) | 2001-01-31 |
HUP9903819A2 (en) | 2000-03-28 |
NO990272L (en) | 1999-03-22 |
NO990272D0 (en) | 1999-01-21 |
CZ18999A3 (en) | 1999-05-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6328034B1 (en) | Dry powder inhaler | |
WO1998003217A9 (en) | Dry powder inhaler | |
EP0028162B1 (en) | Breath actuated devices for administering powdered medicaments | |
US6273085B1 (en) | Dry powder inhaler | |
AU746970B2 (en) | Dry powder inhaler | |
US7069929B2 (en) | Dry powder inhaler | |
US6941947B2 (en) | Unit dose dry powder inhaler | |
US5492112A (en) | Dry powder inhaler | |
US6029662A (en) | Compressed-air powder inhaler | |
AU695051B2 (en) | Dry powder inhaler delivery system | |
JP2006502759A (en) | Powder inhaler | |
EP1748813A1 (en) | Unit dose dry powder inhales | |
GB2061735A (en) | Breath actuated device for administration of powdered medicaments by inhalation | |
AU740035B2 (en) | Dry powder inhaler | |
CA2261172A1 (en) | Dry powder inhaler | |
MXPA99000824A (en) | Dust inhaler s | |
MXPA00005436A (en) | Dry powder inhaler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |