US20010049551A1 - Polymer coated stent - Google Patents
Polymer coated stent Download PDFInfo
- Publication number
- US20010049551A1 US20010049551A1 US09/272,538 US27253899A US2001049551A1 US 20010049551 A1 US20010049551 A1 US 20010049551A1 US 27253899 A US27253899 A US 27253899A US 2001049551 A1 US2001049551 A1 US 2001049551A1
- Authority
- US
- United States
- Prior art keywords
- stent
- tubular
- graft
- polymeric coating
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/89—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/075—Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
Definitions
- the present invention relates generally to a tubular implantable prosthesis formed of porous polytetrafluoroethylene. More particularly, the present invention relates to a stent/graft composite device including a polymeric coated stent in conjunction with an ePTFE graft.
- An endoluminal prosthesis is a medical device commonly known to be used in the treatment of diseased blood vessels.
- An endoluminal prosthesis is typically used to repair, replace, or otherwise correct a damaged blood vessel.
- An artery or vein may be diseased in a variety of different ways. The prosthesis may therefore be used to prevent or treat a wide variety of defects such as stenosis of the vessel, thrombosis, occlusion, or an aneurysm.
- a stent is a generally longitudinal tubular device which is useful to open and support various lumens in the body.
- stents may be used in the vascular system, urogenital tract and bile duct, as well as in a variety of other applications in the body.
- Endovascular stents have become widely used for the treatment of stenosis, strictures, and aneurysms in various blood vessels. These devices are implanted within the vessel to open and/or reinforce collapsing or partially occluded sections of the vessel.
- Stents are generally open ended and are radially expandable between a generally unexpanded insertion diameter and an expanded implantation diameter which is greater than the unexpanded insertion diameter. Stents are often flexible in configuration, which allows them to be inserted through and conform to tortuous pathways in the blood vessel. The stent is generally inserted in a radially compressed state and expanded either through a self-expanding mechanism, or through the use of balloon catheters.
- a graft is another type of endoluminal prosthesis which is used to repair and replace various body vessels. Whereas a stent provides structural support to hold a damaged vessel open, a graft provides an artificial lumen through which blood may flow. Grafts are tubular devices which may be formed of a variety of material, including textile and non-textile materials.
- One type of non-textile material particularly suitable for use as an implantable prosthesis is polytetrafluoroethylene (PTFE).
- PTFE polytetrafluoroethylene
- PTFE exhibits superior biocompatibility and low thrombogenicity, which makes it particularly useful as vascular graft material in the repair or replacement of blood vessels.
- the grafts are manufactured from expanded PTFE (ePTFE) tubes. These tubes have a microporous structure which allows natural tissue ingrowth and cell endothelialization once implanted in the vascular system. This contributes to long term healing and patency of the graft.
- a stent and a graft to form a composite medical device.
- Such devices are often referred to as stent/grafts.
- Such a composite medical device provides additional support for blood flow through weakened sections of a blood vessel.
- the use of a stent/graft combination is becoming increasingly important because the combination not only effectively allows the passage of blood therethrough, but also ensures the implant will remain open and stable.
- the graft can reduce the overall longitudinal flexibility of the composite device. Longitudinal flexibility is of particular importance to such stent/graft endoluminal prosthesis as the device must be intraluminally delivered through tortuous pathways of a blood vessel to the implantation site where the stent is expanded.
- U.S. Pat. No. 5,151,105 issued to Kwan-Gett discloses a collapsible textile vessel sleeve that is collapsible to a very small diameter in order that it may be placed in position within the abdominal or thoracic aorta by a catheter via the lumen of the femoral artery. Such a procedure obviates the need for a major surgical intervention, and reduces the risks associated with such a procedure.
- Other stent/graft composite devices using a fabric are shown in U.S. Pat. No. 5,628,788 to Pinchuck.
- U.S. Pat. No. 5,575,818 issued to Pinchuk discloses polyurethane coatings which may be applied to a stent to form a stent/graft.
- the coatings disclosed may be bonded to the stent through the use of many different methods. For example, an inner lining or coating can be first spun on a mandrel, after which a stent covered with an adhesive substance is pulled down on the lining and then the adhesive is cured, melted and solidified or dried.
- Another alternative is to place the stent on a mandrel, apply (e.g., spray, dip, pad, etc.) a thin coating of polyurethane lacquer over the stent, and then spin the coating over the lacquer so that it is bonded to the stent once the lacquer dries.
- apply e.g., spray, dip, pad, etc.
- the present invention provides a tubular intraluminal prosthesis including at least one PTFE tubular structure with opposed interior and exterior surfaces.
- a tubular diametrically deformable stent is at least partially coated with a polymeric coating, and the at least partially coated stent is affixed to said tubular structure at the portions of the stent.
- a second PTFE tubular structure on the remaining uncovered side of the stent is also contemplated.
- a method of forming the intraluminal prosthesis includes the providing a tubular stent, coating at least a portion of said stent with a polymeric coating applied from a liquid or particulate state, providing a tubular PTFE graft structure, and affixing said coated stent to said tubular PTFE graft structure.
- FIG. 1 is a perspective showing of a collapsed standard wave-like stent which may be used in the present intraluminal prosthesis.
- FIG. 2 is a perspective showing of a collapsed standard wave-like stent with a polymeric coating.
- FIG. 3 is a perspective showing of the coated stent of FIG. 2 expanded over a mandrel.
- FIG. 4 is a perspective showing of an ePTFE tube formed from a wrapped sheet.
- FIG. 5 is a perspective showing of the coated stent of FIG. 2 positioned over an ePTFE tube of FIG. 4.
- FIG. 6 is a perspective showing of a further embodiment of the present invention employing a stent with a partial polymeric coating over a PTFE tube.
- FIG. 7 is a perspective showing a different type of a stent which may be used in the present invention.
- stent types and stent constructions may be employed in the invention.
- various stents useful include, without limitation, self-expanding stents and balloon expandable extents.
- the stents may be capable of radially contracting, as well, and in this sense can best be described as radially distensible or deformable.
- Self-expanding stents include those that have a spring-like action which causes the stent to radially expand, or stents which expand due to the memory properties of the stent material for a particular configuration at a certain temperature.
- Nitinol is one material which has the ability to perform well while both in spring-like mode, as well as in a memory mode based on temperature.
- Other materials are of course contemplated, such as stainless steel, platinum, gold, titanium and other biocompatible metals, as well as polymeric stents.
- the configuration of the stent may also be chosen from a host of geometries.
- wire stents can be fastened into a continuous helical pattern, with or without a wave-like or zig-zag in the wire, to form a radially deformable stent.
- Individual rings or circular members can be linked together such as by struts, sutures, welding or interlacing or locking of the rings to form a tubular stent.
- Tubular stents useful in the present invention also include those formed by etching or cutting a pattern from a tube. Such stents are often referred to as slotted stents.
- stents may be formed by etching a pattern into a material or mold and depositing stent material in the pattern, such as by chemical vapor deposition or the like.
- the present invention provides a stent/graft composite endoluminal prostheses 22 shown in FIG. 5 including a stent 2 of the type shown in FIG. 1 secured to a tubular graft 16 of the type shown in FIG. 4.
- An improved method of forming such composite structure in accordance with the present invention includes providing a an adhesive bond between stent 2 and graft 16 by use of a polymeric coating 14 on stent 2 as shown in FIG. 2.
- Stent 2 is formed from an elongate wire 4 which is helically wound with a plurality of longitudinally spaced turns into an open tubular configuration.
- Stent 2 is an expandable tubular member which may be either of the balloon-expandable or self-expandable type.
- one type of self-expanding stent may be formed of a shaped memory material such as nitinol.
- the elongate helically wound wire 4 forming stent 2 defines successive upper wave-like peaks 10 and lower wave-like peaks 12 . Wire 4 is wound into a specific configuration where upper peaks 10 are placed adjacent to lower peaks 12 of the next adjacent winding.
- stent 2 is coated with polymeric coating 14 .
- Polymeric coating 14 is a biocompatible material, desirably PTFE.
- Polymeric coatings useful in the present invention include those biocompatible materials which are capable of adhering to PTFE grafts and desirably ePTFE grafts. Among those coatings contemplated are polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), polyurethane, fluorinated ethylene propylene (FEP), silicone, polyurethane-acrylate, silicone-acrylate, urethane-silicone, and the like. Combinations of these polymers may also be useful. Portions of the stent may also be coated with different polymers.
- One particularly desirable form of polymer coating is one formed by polymeric particles or powder.
- PTFE powder coatings have been found to be especially useful in the present invention since these coatings bond well under heat and pressure to ePTFE tubular grafts.
- Other coatings are contemplated, however, and can include those which can flow into the porous structure of the graft or which are capable of bonding to PTFE or ePTFE.
- the polymeric coating may be applied to stent 2 using a number of different techniques.
- Two preferred examples of application of coating 14 include spraying the stent with a spray of PTFE particles or dip coating the stent in a mixture containing PTFE particles.
- Powder coating generally refers to a variety of methods employing powdered plastics and resins which are used commercially to apply coatings to various articles. These methods include fluidized bed, electrostatic spray, electrostatic fluidized bed, plasma spray, and hot flocking, as well as combinations and variants of these methods.
- a coating powder is withdrawn from a reservoir in an air stream and electrostatically charged in the high voltage corona field of a spray gun.
- the charged particles are attracted to the grounded metal object to be coated and adhere to it by electrostatic attraction.
- the coated substrate is then placed in an oven and the coating is fused to form a substantially continuous film.
- the discrete PTFE particles form a connected path around the stent.
- the relatively high viscosity of the PTFE melt serves to effectuate a superior coating. If the powder is sprayed on a preheated article, the powder melts and fuses directly on the hot surface; further heating to fuse or cure the coating may be required, depending upon the type of coating powder.
- Plasma coating is a method comprising establishing a hot temperature plasma in an inert gas such as nitrogen, and the coating powder is introduced at the periphery of the plasma. The particles melt and are propelled at high velocity to the substrate, where they form a film.
- hot flocking techniques powders are usually dispersed in air and sprayed or blown onto the preheated substrate, where they melt and form a coating.
- small parts are preheated and dropped into a bed of powder kept in a mobile state by vibration. In this method, the parts are completely coated with an unfused layer of powder on the surface.
- Another method for coating the stent is to suspend stent 2 in the air, such as, on a hook, and spray the polymeric coating onto the stent according to the electrostatic spray method mentioned above.
- An advantage of applying the powder coating in this manner is that it would sufficiently coat the stent in its entirety, and thus provide improved adhesion at its mating surface to the graft.
- FIG. 3 a desirable method for applying coating 14 to stent 6 is shown.
- Stent 6 is shown in an expanded state, and may be supported on a mandrel 8 .
- Mandrel 8 is a rod-like stainless steel member of diameter approximately equal to that of the expanded stent.
- stent 6 is polymeric coated with coating 14 .
- PTFE polymeric coating 14 desirably forms a thin film on the wire. The thickness of the PTFE coating generally ranges from about 1 to about 100 microns.
- Coated stent 6 can then be removed from mandrel 8 tubular graft 16 to form the composite structure, or left on mandrel 8 and tubular graft 16 placed thereover.
- Assembly of the stent/graft prosthesis includes the steps to positioning the graft either on the outside or the inside of the stent and using the combination of heat and pressure sufficient to adheringly assemble the components together.
- Tubular graft material can be used on both the interior and exterior of the tubular stent, as well.
- the graft may be a continuous tube, or may be formed with discontinuous sections. Tubular wrapping in a helical pattern is also contemplated.
- the entire stent may be coated with polymeric coating 14 . It is further contemplated, however, that the stent may be partially coated with the polymeric coating at selected regions (FIG. 6) for purposes which will be described in detail hereinbelow.
- graft 16 is a tubular structure of conventional construction formed of ePTFE. Graft 16 may be extruded as a tube or may be formed from an extruded sheet which is subsequently formed into a tubular structure. Textile or fabric constructions formed of PTFE or ePTFE yarns, filaments or mesh may also be employed.
- FIG. 5 shows a perspective of a composite endoluminal prosthesis 22 comprised of stent 6 with polymeric coating 14 , which circumferentially encloses ePTFE graft 16 .
- the PTFE polymeric coating provides a bonding interface between the stent wire and the graft 16 .
- the coated stent 6 is bonded to graft 16 by sintering the composite structure over a suitable mandrel such as, for example, mandrel 8 (FIG. 3).
- this bonding interface may be enhanced by first coating the stent with the PTFE polymeric coating, then less than fully sintering the PTFE coating on stent 6 .
- the stent By sintering stent 6 less than fully, i.e. only partially sintering, the stent can then be placed on the ePTFE tubular graft 16 and sintered again over the mandrel. The subsequent sintering of the partially sintered coating 14 on graft 16 serves to increase bonded interface between graft 16 and stent 6 .
- a composite intraluminal prosthesis 24 is shown including an ePTFE graft 16 , circumferentially enclosed by a partially coated polymeric stent 26 .
- the composite structure may be assembled as described above.
- stent 26 is partially coated with PTFE coating 14 at areas intermediate of the undulations in the stent.
- the upper and lower wave-like peaks 10 , and 12 respectively are subsequently left exteriorly exposed without PTFE coating.
- This embodiment provides the composite graft with increased flexibility as the unexposed peaks do not readily bond to the graft. This provides multiple points of flexure throughout the length of the composite prosthesis 22 .
- FIG. 7 shows another stent configuration which may be used in the present invention is shown.
- Stent 30 may be the type more fully described in U.S. Pat. No. 4,733,665, and is herein incorporated by reference.
- Stent 30 is an expandable and deformable tubular structure including a plurality of longitudinally extending parallel struts 31 connected to one another by transverse tabs 34 .
- the struts 31 and tabs 34 define slots 32 which define open spaces 35 through the tube.
- Stent 30 fully or partially coated as described above is subsequently bound to a tubular graft 16 (FIG. 4) in a manner described above to form a composite endoluminal prosthesis 22 .
Landscapes
- Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
- The present invention relates generally to a tubular implantable prosthesis formed of porous polytetrafluoroethylene. More particularly, the present invention relates to a stent/graft composite device including a polymeric coated stent in conjunction with an ePTFE graft.
- An endoluminal prosthesis is a medical device commonly known to be used in the treatment of diseased blood vessels. An endoluminal prosthesis is typically used to repair, replace, or otherwise correct a damaged blood vessel. An artery or vein may be diseased in a variety of different ways. The prosthesis may therefore be used to prevent or treat a wide variety of defects such as stenosis of the vessel, thrombosis, occlusion, or an aneurysm.
- One type of endoluminal prosthesis used in the repair of diseases in various body vessels is a stent. A stent is a generally longitudinal tubular device which is useful to open and support various lumens in the body. For example, stents may be used in the vascular system, urogenital tract and bile duct, as well as in a variety of other applications in the body. Endovascular stents have become widely used for the treatment of stenosis, strictures, and aneurysms in various blood vessels. These devices are implanted within the vessel to open and/or reinforce collapsing or partially occluded sections of the vessel.
- Stents are generally open ended and are radially expandable between a generally unexpanded insertion diameter and an expanded implantation diameter which is greater than the unexpanded insertion diameter. Stents are often flexible in configuration, which allows them to be inserted through and conform to tortuous pathways in the blood vessel. The stent is generally inserted in a radially compressed state and expanded either through a self-expanding mechanism, or through the use of balloon catheters.
- A graft is another type of endoluminal prosthesis which is used to repair and replace various body vessels. Whereas a stent provides structural support to hold a damaged vessel open, a graft provides an artificial lumen through which blood may flow. Grafts are tubular devices which may be formed of a variety of material, including textile and non-textile materials. One type of non-textile material particularly suitable for use as an implantable prosthesis is polytetrafluoroethylene (PTFE). PTFE exhibits superior biocompatibility and low thrombogenicity, which makes it particularly useful as vascular graft material in the repair or replacement of blood vessels. In vascular applications, the grafts are manufactured from expanded PTFE (ePTFE) tubes. These tubes have a microporous structure which allows natural tissue ingrowth and cell endothelialization once implanted in the vascular system. This contributes to long term healing and patency of the graft.
- It is also known to combine a stent and a graft to form a composite medical device. Such devices are often referred to as stent/grafts. Such a composite medical device provides additional support for blood flow through weakened sections of a blood vessel. In endovascular applications the use of a stent/graft combination is becoming increasingly important because the combination not only effectively allows the passage of blood therethrough, but also ensures the implant will remain open and stable. However, the graft can reduce the overall longitudinal flexibility of the composite device. Longitudinal flexibility is of particular importance to such stent/graft endoluminal prosthesis as the device must be intraluminally delivered through tortuous pathways of a blood vessel to the implantation site where the stent is expanded.
- Several types of stent/graft inventions are known in the art. For example, U.S. Pat. No. 5,151,105 issued to Kwan-Gett discloses a collapsible textile vessel sleeve that is collapsible to a very small diameter in order that it may be placed in position within the abdominal or thoracic aorta by a catheter via the lumen of the femoral artery. Such a procedure obviates the need for a major surgical intervention, and reduces the risks associated with such a procedure. Other stent/graft composite devices using a fabric are shown in U.S. Pat. No. 5,628,788 to Pinchuck.
- U.S. Pat. No. 5,575,818 issued to Pinchuk discloses polyurethane coatings which may be applied to a stent to form a stent/graft. The coatings disclosed may be bonded to the stent through the use of many different methods. For example, an inner lining or coating can be first spun on a mandrel, after which a stent covered with an adhesive substance is pulled down on the lining and then the adhesive is cured, melted and solidified or dried. Another alternative is to place the stent on a mandrel, apply (e.g., spray, dip, pad, etc.) a thin coating of polyurethane lacquer over the stent, and then spin the coating over the lacquer so that it is bonded to the stent once the lacquer dries.
- One difficulty encountered in stent/graft structures which employ PTFE or ePTFE as the graft portion, is obtaining a proper bond between the stent, which is usually metallic or other material dissimilar to the graft portion. For example, U.S. Pat. Nos. 5,700,285, 5,735,892 and 5,810,870 to Myers et al. disclose the use of two ePTFE tubular sheets which are bonded together through the space between a stent sandwiched therebetween. These patents also disclose the use of fluorinated ethylene propylene (FEP) as an adhesive for bonding the stent to a tubular sheet or sheets.
- It is well recognized, however, that few materials bond well to PTFE or ePTFE due to its chemical makeup. The surface of PTFE materials is difficult to wet and the relatively small pore sizes of ePTFE are difficult to penetrate effectively to obtain good mechanical bonds.
- Thus, while ePTFE has shown to possess many desirous characteristics for use in conjunction with a stent, attachment of the polymeric tubular grafts to the stent has always presented its challenges. Due to the physical and chemical inertness of an ePTFE vascular graft, thus, it is difficult to adheringly attach such grafts to other structures. The present invention addresses inherent difficulty in bonding the stent.
- It is therefore an advantage provided by the present invention to provide a composite stent/graft prosthesis exhibiting both the benefits of a composite endoluminal stent/graft prosthesis while maintaining the flexibility of an uncovered stent.
- It is a further advantage provided by the present invention to provide a biocompatible surface to an uncovered stent through the application of a polymeric material coating which is capable of adhereing to PTFE or ePTFE.
- In the efficient attainment of these and other objects, the present invention provides a tubular intraluminal prosthesis including at least one PTFE tubular structure with opposed interior and exterior surfaces. A tubular diametrically deformable stent is at least partially coated with a polymeric coating, and the at least partially coated stent is affixed to said tubular structure at the portions of the stent. A second PTFE tubular structure on the remaining uncovered side of the stent is also contemplated.
- A method of forming the intraluminal prosthesis is also provided, which includes the providing a tubular stent, coating at least a portion of said stent with a polymeric coating applied from a liquid or particulate state, providing a tubular PTFE graft structure, and affixing said coated stent to said tubular PTFE graft structure.
- FIG. 1 is a perspective showing of a collapsed standard wave-like stent which may be used in the present intraluminal prosthesis.
- FIG. 2 is a perspective showing of a collapsed standard wave-like stent with a polymeric coating.
- FIG. 3 is a perspective showing of the coated stent of FIG. 2 expanded over a mandrel.
- FIG. 4 is a perspective showing of an ePTFE tube formed from a wrapped sheet.
- FIG. 5 is a perspective showing of the coated stent of FIG. 2 positioned over an ePTFE tube of FIG. 4.
- FIG. 6 is a perspective showing of a further embodiment of the present invention employing a stent with a partial polymeric coating over a PTFE tube.
- FIG. 7 is a perspective showing a different type of a stent which may be used in the present invention.
- The following is a detailed description of the preferred embodiments of the present invention. The description is meant to describe preferred embodiments, and is not meant to limit the invention in any way.
- Various stent types and stent constructions may be employed in the invention. Among the various stents useful include, without limitation, self-expanding stents and balloon expandable extents. The stents may be capable of radially contracting, as well, and in this sense can best be described as radially distensible or deformable. Self-expanding stents include those that have a spring-like action which causes the stent to radially expand, or stents which expand due to the memory properties of the stent material for a particular configuration at a certain temperature. Nitinol is one material which has the ability to perform well while both in spring-like mode, as well as in a memory mode based on temperature. Other materials are of course contemplated, such as stainless steel, platinum, gold, titanium and other biocompatible metals, as well as polymeric stents.
- The configuration of the stent may also be chosen from a host of geometries. For example, wire stents can be fastened into a continuous helical pattern, with or without a wave-like or zig-zag in the wire, to form a radially deformable stent. Individual rings or circular members can be linked together such as by struts, sutures, welding or interlacing or locking of the rings to form a tubular stent. Tubular stents useful in the present invention also include those formed by etching or cutting a pattern from a tube. Such stents are often referred to as slotted stents. Furthermore, stents may be formed by etching a pattern into a material or mold and depositing stent material in the pattern, such as by chemical vapor deposition or the like.
- The present invention provides a stent/graft composite
endoluminal prostheses 22 shown in FIG. 5 including astent 2 of the type shown in FIG. 1 secured to atubular graft 16 of the type shown in FIG. 4. An improved method of forming such composite structure in accordance with the present invention includes providing a an adhesive bond betweenstent 2 andgraft 16 by use of apolymeric coating 14 onstent 2 as shown in FIG. 2. - Referring specifically to FIGS. 1 and 2 of the drawings, one type of stent which may be included in the composite endoluminal prosthesis of the present invention is shown.
Stent 2 is formed from anelongate wire 4 which is helically wound with a plurality of longitudinally spaced turns into an open tubular configuration.Stent 2 is an expandable tubular member which may be either of the balloon-expandable or self-expandable type. As previously discussed, one type of self-expanding stent may be formed of a shaped memory material such as nitinol. The elongatehelically wound wire 4 formingstent 2 defines successive upper wave-like peaks 10 and lower wave-like peaks 12.Wire 4 is wound into a specific configuration whereupper peaks 10 are placed adjacent tolower peaks 12 of the next adjacent winding. - In order to effectively form the composite endoluminal prosthesis of the present invention,
stent 2 is coated withpolymeric coating 14.Polymeric coating 14 is a biocompatible material, desirably PTFE. Polymeric coatings useful in the present invention include those biocompatible materials which are capable of adhering to PTFE grafts and desirably ePTFE grafts. Among those coatings contemplated are polytetrafluoroethylene (PTFE), expanded PTFE (ePTFE), polyurethane, fluorinated ethylene propylene (FEP), silicone, polyurethane-acrylate, silicone-acrylate, urethane-silicone, and the like. Combinations of these polymers may also be useful. Portions of the stent may also be coated with different polymers. - One particularly desirable form of polymer coating is one formed by polymeric particles or powder. PTFE powder coatings have been found to be especially useful in the present invention since these coatings bond well under heat and pressure to ePTFE tubular grafts. Other coatings are contemplated, however, and can include those which can flow into the porous structure of the graft or which are capable of bonding to PTFE or ePTFE.
- The polymeric coating may be applied to
stent 2 using a number of different techniques. Two preferred examples of application ofcoating 14 include spraying the stent with a spray of PTFE particles or dip coating the stent in a mixture containing PTFE particles. Powder coating generally refers to a variety of methods employing powdered plastics and resins which are used commercially to apply coatings to various articles. These methods include fluidized bed, electrostatic spray, electrostatic fluidized bed, plasma spray, and hot flocking, as well as combinations and variants of these methods. - In the electrostatic spray process, a coating powder is withdrawn from a reservoir in an air stream and electrostatically charged in the high voltage corona field of a spray gun. The charged particles are attracted to the grounded metal object to be coated and adhere to it by electrostatic attraction. The coated substrate is then placed in an oven and the coating is fused to form a substantially continuous film. The discrete PTFE particles form a connected path around the stent. The relatively high viscosity of the PTFE melt serves to effectuate a superior coating. If the powder is sprayed on a preheated article, the powder melts and fuses directly on the hot surface; further heating to fuse or cure the coating may be required, depending upon the type of coating powder.
- Plasma coating is a method comprising establishing a hot temperature plasma in an inert gas such as nitrogen, and the coating powder is introduced at the periphery of the plasma. The particles melt and are propelled at high velocity to the substrate, where they form a film. In hot flocking techniques, powders are usually dispersed in air and sprayed or blown onto the preheated substrate, where they melt and form a coating. In a variant of this process, small parts are preheated and dropped into a bed of powder kept in a mobile state by vibration. In this method, the parts are completely coated with an unfused layer of powder on the surface.
- Another method for coating the stent is to suspend
stent 2 in the air, such as, on a hook, and spray the polymeric coating onto the stent according to the electrostatic spray method mentioned above. An advantage of applying the powder coating in this manner, is that it would sufficiently coat the stent in its entirety, and thus provide improved adhesion at its mating surface to the graft. - Referring to FIG. 3, a desirable method for applying
coating 14 to stent 6 is shown. Stent 6 is shown in an expanded state, and may be supported on amandrel 8.Mandrel 8 is a rod-like stainless steel member of diameter approximately equal to that of the expanded stent. Once positioned onmandrel 8, stent 6 is polymeric coated withcoating 14.PTFE polymeric coating 14 desirably forms a thin film on the wire. The thickness of the PTFE coating generally ranges from about 1 to about 100 microns. Coated stent 6 can then be removed frommandrel 8tubular graft 16 to form the composite structure, or left onmandrel 8 andtubular graft 16 placed thereover. - Assembly of the stent/graft prosthesis includes the steps to positioning the graft either on the outside or the inside of the stent and using the combination of heat and pressure sufficient to adheringly assemble the components together. Tubular graft material can be used on both the interior and exterior of the tubular stent, as well. The graft may be a continuous tube, or may be formed with discontinuous sections. Tubular wrapping in a helical pattern is also contemplated.
- As shown in FIG. 2, the entire stent may be coated with
polymeric coating 14. It is further contemplated, however, that the stent may be partially coated with the polymeric coating at selected regions (FIG. 6) for purposes which will be described in detail hereinbelow. - Referring now to FIG. 4,
graft 16 is a tubular structure of conventional construction formed of ePTFE.Graft 16 may be extruded as a tube or may be formed from an extruded sheet which is subsequently formed into a tubular structure. Textile or fabric constructions formed of PTFE or ePTFE yarns, filaments or mesh may also be employed. - FIG. 5 shows a perspective of a
composite endoluminal prosthesis 22 comprised of stent 6 withpolymeric coating 14, which circumferentially enclosesePTFE graft 16. The PTFE polymeric coating provides a bonding interface between the stent wire and thegraft 16. The coated stent 6 is bonded to graft 16 by sintering the composite structure over a suitable mandrel such as, for example, mandrel 8 (FIG. 3). - It is further contemplated that this bonding interface may be enhanced by first coating the stent with the PTFE polymeric coating, then less than fully sintering the PTFE coating on stent6. By sintering stent 6 less than fully, i.e. only partially sintering, the stent can then be placed on the ePTFE
tubular graft 16 and sintered again over the mandrel. The subsequent sintering of the partially sintered coating 14 ongraft 16 serves to increase bonded interface betweengraft 16 and stent 6. - Referring to FIG. 6, a further embodiment of the present invention is shown. A composite intraluminal prosthesis24 is shown including an
ePTFE graft 16, circumferentially enclosed by a partially coatedpolymeric stent 26. The composite structure may be assembled as described above. In this embodiment of the present invention,stent 26 is partially coated withPTFE coating 14 at areas intermediate of the undulations in the stent. By partially coating stent 6, the upper and lower wave-like peaks composite prosthesis 22. - The particular wire stent6 of FIGS. 1-6 is shown as merely one example. Other stent configurations, as discussed above, may be employed. For example, FIG. 7 shows another stent configuration which may be used in the present invention is shown.
Stent 30 may be the type more fully described in U.S. Pat. No. 4,733,665, and is herein incorporated by reference.Stent 30 is an expandable and deformable tubular structure including a plurality of longitudinally extendingparallel struts 31 connected to one another bytransverse tabs 34. Thestruts 31 andtabs 34 defineslots 32 which defineopen spaces 35 through the tube. This stent construction not only ensures patency and flexibility with the slotted configuration, but the configuration of slots and tabs would allow for a partially covered polymeric coating with increased flexibility as shown in FIG. 6.Stent 30 fully or partially coated as described above is subsequently bound to a tubular graft 16 (FIG. 4) in a manner described above to form acomposite endoluminal prosthesis 22. - Various modifications and changes may be made without departing from the spirit and intent of the invention and all such changes are intended to be included in the following claims.
Claims (30)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/272,538 US6364903B2 (en) | 1999-03-19 | 1999-03-19 | Polymer coated stent |
CA002366665A CA2366665C (en) | 1999-03-19 | 2000-03-06 | Polymer coated stent |
PCT/US2000/005976 WO2000056247A1 (en) | 1999-03-19 | 2000-03-06 | Polymer coated stent |
EP00917783A EP1164972B1 (en) | 1999-03-19 | 2000-03-06 | Polymer coated stent |
JP2000606156A JP4672869B2 (en) | 1999-03-19 | 2000-03-06 | Polymer coated stent |
DE60019911T DE60019911T2 (en) | 1999-03-19 | 2000-03-06 | PLASTIC-COATED STENT |
US10/067,584 US6733524B2 (en) | 1999-03-19 | 2002-02-05 | Polymer coated stent |
US10/807,700 US7285132B2 (en) | 1999-03-19 | 2004-03-24 | Polymer coated stent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/272,538 US6364903B2 (en) | 1999-03-19 | 1999-03-19 | Polymer coated stent |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/067,584 Continuation US6733524B2 (en) | 1999-03-19 | 2002-02-05 | Polymer coated stent |
Publications (2)
Publication Number | Publication Date |
---|---|
US20010049551A1 true US20010049551A1 (en) | 2001-12-06 |
US6364903B2 US6364903B2 (en) | 2002-04-02 |
Family
ID=23040223
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/272,538 Expired - Lifetime US6364903B2 (en) | 1999-03-19 | 1999-03-19 | Polymer coated stent |
US10/067,584 Expired - Fee Related US6733524B2 (en) | 1999-03-19 | 2002-02-05 | Polymer coated stent |
US10/807,700 Expired - Fee Related US7285132B2 (en) | 1999-03-19 | 2004-03-24 | Polymer coated stent |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/067,584 Expired - Fee Related US6733524B2 (en) | 1999-03-19 | 2002-02-05 | Polymer coated stent |
US10/807,700 Expired - Fee Related US7285132B2 (en) | 1999-03-19 | 2004-03-24 | Polymer coated stent |
Country Status (6)
Country | Link |
---|---|
US (3) | US6364903B2 (en) |
EP (1) | EP1164972B1 (en) |
JP (1) | JP4672869B2 (en) |
CA (1) | CA2366665C (en) |
DE (1) | DE60019911T2 (en) |
WO (1) | WO2000056247A1 (en) |
Cited By (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003059206A1 (en) * | 2002-01-04 | 2003-07-24 | Boston Scientific Limited | Non-compliant balloon with compliant top-layer to protect coated stents during expansion |
US20030208153A1 (en) * | 2002-05-03 | 2003-11-06 | Stenzel Eric B. | Method, tool, and system for deploying an implant into the body |
US20040230298A1 (en) * | 2003-04-25 | 2004-11-18 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
US20040267353A1 (en) * | 2003-06-25 | 2004-12-30 | Scimed Life Systems, Inc. | Varying circumferential spanned connectors in a stent |
US20050004653A1 (en) * | 2003-06-19 | 2005-01-06 | Scimed Life Systems, Inc. | Sandwiched radiopaque marker on covered stent |
US20050131527A1 (en) * | 2003-12-12 | 2005-06-16 | Pathak Chandrashekhar P. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
US20080140186A1 (en) * | 2003-02-21 | 2008-06-12 | Sorin Biomedica Cardio S.R.L. | Process for producing stents and corresponding stents |
WO2009006106A2 (en) * | 2007-07-05 | 2009-01-08 | Ppg Industries Ohio, Inc. | Aqueous resinous binders |
US20090192588A1 (en) * | 2008-01-29 | 2009-07-30 | Taeoong Medical Co., Ltd | Biodegradable double stent |
US20100030261A1 (en) * | 2006-10-02 | 2010-02-04 | Micell Technologies, Inc. | Surgical Sutures Having Increased Strength |
US7988720B2 (en) | 2006-09-12 | 2011-08-02 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US20120016457A1 (en) * | 2001-12-20 | 2012-01-19 | Trivascular2, Inc. | Barbed radially expandable stent with slotted struts |
US20120022636A1 (en) * | 2001-12-20 | 2012-01-26 | Trivascular, Inc. | Method of delivering advanced endovascular graft |
US8298565B2 (en) | 2005-07-15 | 2012-10-30 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US20130172980A1 (en) * | 2002-05-31 | 2013-07-04 | W. L. Gore & Associates, Inc. | Implantable product with improved aqueous interface characteristics and methods for making and using the same |
US20140074220A1 (en) * | 2004-05-14 | 2014-03-13 | Boston Scientific Scimed, Inc. | Stent With Reduced Weld Profiles and a Closed-End Wire Configuration |
US20140081414A1 (en) * | 2012-09-19 | 2014-03-20 | Merit Medical Systems, Inc. | Electrospun material covered medical appliances and methods of manufacture |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US20140277381A1 (en) * | 2013-03-14 | 2014-09-18 | W. L. Gore & Associates, Inc. | Methods and apparatus for assembling stent-grafts |
US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US8900651B2 (en) | 2007-05-25 | 2014-12-02 | Micell Technologies, Inc. | Polymer films for medical device coating |
US20160160413A1 (en) * | 2009-08-07 | 2016-06-09 | Zeus Industrial Products, Inc. | Multilayered composite |
US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
US9474517B2 (en) | 2008-03-07 | 2016-10-25 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
US9486431B2 (en) | 2008-07-17 | 2016-11-08 | Micell Technologies, Inc. | Drug delivery medical device |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US9636309B2 (en) | 2010-09-09 | 2017-05-02 | Micell Technologies, Inc. | Macrolide dosage forms |
US9655710B2 (en) | 2011-01-28 | 2017-05-23 | Merit Medical Systems, Inc. | Process of making a stent |
US9737642B2 (en) | 2007-01-08 | 2017-08-22 | Micell Technologies, Inc. | Stents having biodegradable layers |
US20170246352A1 (en) * | 2002-04-01 | 2017-08-31 | Abbott Cardiovascular Systems Inc. | Hybrid stent and method of making |
US9770232B2 (en) | 2011-08-12 | 2017-09-26 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
US9789233B2 (en) | 2008-04-17 | 2017-10-17 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US9808230B2 (en) | 2014-06-06 | 2017-11-07 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US9827703B2 (en) | 2013-03-13 | 2017-11-28 | Merit Medical Systems, Inc. | Methods, systems, and apparatuses for manufacturing rotational spun appliances |
US9856588B2 (en) | 2009-01-16 | 2018-01-02 | Zeus Industrial Products, Inc. | Electrospinning of PTFE |
US9949728B2 (en) | 2007-04-05 | 2018-04-24 | W.L. Gore & Associates, Inc. | Septal closure device with centering mechanism |
US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
US10005269B2 (en) | 2012-01-16 | 2018-06-26 | Merit Medical Systems, Inc. | Rotational spun material covered medical appliances and methods of manufacture |
US10010395B2 (en) | 2012-04-05 | 2018-07-03 | Zeus Industrial Products, Inc. | Composite prosthetic devices |
US10028852B2 (en) | 2015-02-26 | 2018-07-24 | Merit Medical Systems, Inc. | Layered medical appliances and methods |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US10272606B2 (en) | 2013-05-15 | 2019-04-30 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US10327924B2 (en) * | 2015-07-19 | 2019-06-25 | Sanford Health | Bridging stent graft with combination balloon expandable and self-expandable stents and methods for use |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US10792025B2 (en) | 2009-06-22 | 2020-10-06 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10799617B2 (en) | 2013-03-13 | 2020-10-13 | Merit Medical Systems, Inc. | Serially deposited fiber materials and associated devices and methods |
US10806437B2 (en) | 2009-06-22 | 2020-10-20 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10828019B2 (en) | 2013-01-18 | 2020-11-10 | W.L. Gore & Associates, Inc. | Sealing device and delivery system |
US10835396B2 (en) | 2005-07-15 | 2020-11-17 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
US11375988B2 (en) | 2003-07-14 | 2022-07-05 | W. L. Gore & Associates, Inc. | Patent foramen ovale (PFO) closure device with linearly elongating petals |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US11583313B1 (en) | 2018-12-06 | 2023-02-21 | Spiway Llc | Surgical access sheath and methods of use |
US11904118B2 (en) | 2010-07-16 | 2024-02-20 | Micell Medtech Inc. | Drug delivery medical device |
US12082795B2 (en) | 2020-09-28 | 2024-09-10 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
Families Citing this family (191)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7204848B1 (en) | 1995-03-01 | 2007-04-17 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US6579314B1 (en) * | 1995-03-10 | 2003-06-17 | C.R. Bard, Inc. | Covered stent with encapsulated ends |
US6264684B1 (en) | 1995-03-10 | 2001-07-24 | Impra, Inc., A Subsidiary Of C.R. Bard, Inc. | Helically supported graft |
US6451047B2 (en) | 1995-03-10 | 2002-09-17 | Impra, Inc. | Encapsulated intraluminal stent-graft and methods of making same |
US6433154B1 (en) * | 1997-06-12 | 2002-08-13 | Bristol-Myers Squibb Company | Functional receptor/kinase chimera in yeast cells |
US7947015B2 (en) | 1999-01-25 | 2011-05-24 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US6955661B1 (en) * | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
US6398803B1 (en) | 1999-02-02 | 2002-06-04 | Impra, Inc., A Subsidiary Of C.R. Bard, Inc. | Partial encapsulation of stents |
US20020081732A1 (en) * | 2000-10-18 | 2002-06-27 | Bowlin Gary L. | Electroprocessing in drug delivery and cell encapsulation |
US7615373B2 (en) * | 1999-02-25 | 2009-11-10 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed collagen and tissue engineering |
US6364903B2 (en) * | 1999-03-19 | 2002-04-02 | Meadox Medicals, Inc. | Polymer coated stent |
US6730349B2 (en) * | 1999-04-19 | 2004-05-04 | Scimed Life Systems, Inc. | Mechanical and acoustical suspension coating of medical implants |
US7807211B2 (en) * | 1999-09-03 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Thermal treatment of an implantable medical device |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
US6503556B2 (en) | 2000-12-28 | 2003-01-07 | Advanced Cardiovascular Systems, Inc. | Methods of forming a coating for a prosthesis |
US6953476B1 (en) * | 2000-03-27 | 2005-10-11 | Neovasc Medical Ltd. | Device and method for treating ischemic heart disease |
WO2001087491A1 (en) | 2000-05-16 | 2001-11-22 | Regents Of The University Of Minnesota | High mass throughput particle generation using multiple nozzle spraying |
CA2457162A1 (en) * | 2000-09-01 | 2002-03-07 | Virginia Commonwealth University Intellectual Property Foundation | Electroprocessed fibrin-based matrices and tissues |
US6652574B1 (en) * | 2000-09-28 | 2003-11-25 | Vascular Concepts Holdings Limited | Product and process for manufacturing a wire stent coated with a biocompatible fluoropolymer |
US6616876B1 (en) * | 2000-10-03 | 2003-09-09 | Atrium Medical Corporation | Method for treating expandable polymer materials |
US6923927B2 (en) * | 2000-10-03 | 2005-08-02 | Atrium Medical Corporation | Method for forming expandable polymers having drugs or agents included therewith |
US7504125B1 (en) | 2001-04-27 | 2009-03-17 | Advanced Cardiovascular Systems, Inc. | System and method for coating implantable devices |
US6540776B2 (en) | 2000-12-28 | 2003-04-01 | Advanced Cardiovascular Systems, Inc. | Sheath for a prosthesis and methods of forming the same |
US7247338B2 (en) * | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
US6605154B1 (en) * | 2001-05-31 | 2003-08-12 | Advanced Cardiovascular Systems, Inc. | Stent mounting device |
US7510571B2 (en) * | 2001-06-11 | 2009-03-31 | Boston Scientific, Scimed, Inc. | Pleated composite ePTFE/textile hybrid covering |
US6572644B1 (en) * | 2001-06-27 | 2003-06-03 | Advanced Cardiovascular Systems, Inc. | Stent mounting device and a method of using the same to coat a stent |
WO2003002243A2 (en) | 2001-06-27 | 2003-01-09 | Remon Medical Technologies Ltd. | Method and device for electrochemical formation of therapeutic species in vivo |
US8741378B1 (en) * | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
US6695920B1 (en) | 2001-06-27 | 2004-02-24 | Advanced Cardiovascular Systems, Inc. | Mandrel for supporting a stent and a method of using the mandrel to coat a stent |
US6673154B1 (en) * | 2001-06-28 | 2004-01-06 | Advanced Cardiovascular Systems, Inc. | Stent mounting device to coat a stent |
US6527863B1 (en) | 2001-06-29 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Support device for a stent and a method of using the same to coat a stent |
US6682771B2 (en) * | 2001-07-02 | 2004-01-27 | Scimed Life Systems, Inc. | Coating dispensing system and method using a solenoid head for coating medical devices |
US8252040B2 (en) | 2001-07-20 | 2012-08-28 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8715312B2 (en) | 2001-07-20 | 2014-05-06 | Microvention, Inc. | Aneurysm treatment device and method of use |
US7572288B2 (en) | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
ES2278952T3 (en) * | 2001-07-26 | 2007-08-16 | Avantec Vascular Corporation | DEVICES FOR MANAGING THERAPEUTIC AGENTS WITH VARIABLE LIBERATION PROFILE. |
US6641611B2 (en) | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US20040137066A1 (en) * | 2001-11-26 | 2004-07-15 | Swaminathan Jayaraman | Rationally designed therapeutic intravascular implant coating |
US6669980B2 (en) * | 2001-09-18 | 2003-12-30 | Scimed Life Systems, Inc. | Method for spray-coating medical devices |
US20030135269A1 (en) * | 2002-01-16 | 2003-07-17 | Swanstrom Lee L. | Laparoscopic-assisted endovascular/endoluminal graft placement |
US6865810B2 (en) * | 2002-06-27 | 2005-03-15 | Scimed Life Systems, Inc. | Methods of making medical devices |
US20040024448A1 (en) * | 2002-08-05 | 2004-02-05 | Chang James W. | Thermoplastic fluoropolymer-coated medical devices |
US6878162B2 (en) | 2002-08-30 | 2005-04-12 | Edwards Lifesciences Ag | Helical stent having improved flexibility and expandability |
US9561123B2 (en) | 2002-08-30 | 2017-02-07 | C.R. Bard, Inc. | Highly flexible stent and method of manufacture |
US6818063B1 (en) * | 2002-09-24 | 2004-11-16 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for minimizing coating defects |
US7776381B1 (en) * | 2002-09-26 | 2010-08-17 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for reducing coating defects |
US7335265B1 (en) | 2002-10-08 | 2008-02-26 | Advanced Cardiovascular Systems Inc. | Apparatus and method for coating stents |
US20040093056A1 (en) | 2002-10-26 | 2004-05-13 | Johnson Lianw M. | Medical appliance delivery apparatus and method of use |
US7637942B2 (en) | 2002-11-05 | 2009-12-29 | Merit Medical Systems, Inc. | Coated stent with geometry determinated functionality and method of making the same |
US7959671B2 (en) | 2002-11-05 | 2011-06-14 | Merit Medical Systems, Inc. | Differential covering and coating methods |
US7875068B2 (en) | 2002-11-05 | 2011-01-25 | Merit Medical Systems, Inc. | Removable biliary stent |
AU2003291311A1 (en) * | 2002-11-07 | 2004-06-03 | Carbon Medical Technologies, Inc. | Biocompatible medical device coatings |
US7416609B1 (en) * | 2002-11-25 | 2008-08-26 | Advanced Cardiovascular Systems, Inc. | Support assembly for a stent |
US7074276B1 (en) | 2002-12-12 | 2006-07-11 | Advanced Cardiovascular Systems, Inc. | Clamp mandrel fixture and a method of using the same to minimize coating defects |
US7628859B1 (en) * | 2002-12-27 | 2009-12-08 | Advanced Cardiovascular Systems, Inc. | Mounting assembly for a stent and a method of using the same to coat a stent |
US7763062B2 (en) * | 2003-01-21 | 2010-07-27 | Boston Scientific Scimed, Inc. | Method and system for delivering and implanting a graft |
US20040148001A1 (en) * | 2003-01-24 | 2004-07-29 | Nolting John E. | Solvent-bonded stent-graft assembly |
US7354480B1 (en) | 2003-02-26 | 2008-04-08 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and system for reducing coating defects |
US20040241750A1 (en) * | 2003-03-24 | 2004-12-02 | David Nordman | Novel methods for determining the negative control value for multi-analyte assays |
US7637934B2 (en) | 2003-03-31 | 2009-12-29 | Merit Medical Systems, Inc. | Medical appliance optical delivery and deployment apparatus and method |
US20040199246A1 (en) * | 2003-04-02 | 2004-10-07 | Scimed Life Systems, Inc. | Expandable stent |
US20040210118A1 (en) * | 2003-04-18 | 2004-10-21 | Michel Letort | In situ detection of endoleak and endotension |
US20040213767A1 (en) * | 2003-04-23 | 2004-10-28 | Marc Hendriks | Methods for using adipose-derived cells for healing of aortic aneurysmal tissue |
US20040215318A1 (en) * | 2003-04-24 | 2004-10-28 | Brian Kwitkin | Timed delivery of therapeutics to blood vessels |
US7396540B2 (en) * | 2003-04-25 | 2008-07-08 | Medtronic Vascular, Inc. | In situ blood vessel and aneurysm treatment |
US7387645B2 (en) * | 2003-04-25 | 2008-06-17 | Medtronic Vascular, Inc. | Cellular therapy to heal vascular tissue |
US20040254629A1 (en) * | 2003-04-25 | 2004-12-16 | Brian Fernandes | Methods and apparatus for treatment of aneurysmal tissue |
US20040215335A1 (en) * | 2003-04-25 | 2004-10-28 | Brin David S. | Methods and apparatus for treatment of aneurysmal tissue |
US20040215320A1 (en) * | 2003-04-25 | 2004-10-28 | James Machek | Integral stent graft |
US7323209B1 (en) * | 2003-05-15 | 2008-01-29 | Advanced Cardiovascular Systems, Inc. | Apparatus and method for coating stents |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US20050013870A1 (en) * | 2003-07-17 | 2005-01-20 | Toby Freyman | Decellularized extracellular matrix of conditioned body tissues and uses thereof |
US20050043786A1 (en) * | 2003-08-18 | 2005-02-24 | Medtronic Ave, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
JP2007505655A (en) * | 2003-09-15 | 2007-03-15 | アトリウム メディカル コーポレーション | Application of therapeutic substances to tissue sites using porous medical devices |
US8021331B2 (en) | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
WO2005027996A2 (en) * | 2003-09-15 | 2005-03-31 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US20050060020A1 (en) * | 2003-09-17 | 2005-03-17 | Scimed Life Systems, Inc. | Covered stent with biologically active material |
US7371228B2 (en) | 2003-09-19 | 2008-05-13 | Medtronic Vascular, Inc. | Delivery of therapeutics to treat aneurysms |
US7244441B2 (en) * | 2003-09-25 | 2007-07-17 | Scios, Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
US7198675B2 (en) | 2003-09-30 | 2007-04-03 | Advanced Cardiovascular Systems | Stent mandrel fixture and method for selectively coating surfaces of a stent |
US20050131513A1 (en) | 2003-12-16 | 2005-06-16 | Cook Incorporated | Stent catheter with a permanently affixed conductor |
US7530994B2 (en) * | 2003-12-30 | 2009-05-12 | Scimed Life Systems, Inc. | Non-porous graft with fastening elements |
US8042485B1 (en) | 2003-12-30 | 2011-10-25 | Advanced Cardiovascular Systems, Inc. | Stent mandrel fixture and method for coating stents |
US8349388B1 (en) | 2004-03-18 | 2013-01-08 | Advanced Cardiovascular Systems, Inc. | Method of coating a stent |
US8500751B2 (en) | 2004-03-31 | 2013-08-06 | Merlin Md Pte Ltd | Medical device |
US8915952B2 (en) | 2004-03-31 | 2014-12-23 | Merlin Md Pte Ltd. | Method for treating aneurysms |
US8377110B2 (en) * | 2004-04-08 | 2013-02-19 | Endologix, Inc. | Endolumenal vascular prosthesis with neointima inhibiting polymeric sleeve |
JP2007534389A (en) * | 2004-04-29 | 2007-11-29 | キューブ・メディカル・アクティーゼルスカブ | Balloon used for angiogenesis |
US20060246109A1 (en) * | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
US20050266043A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and compounds for treatment of aneurysmal tissue |
US20050266042A1 (en) * | 2004-05-27 | 2005-12-01 | Medtronic Vascular, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
US8048409B2 (en) * | 2004-05-27 | 2011-11-01 | Medtronic Vascular, Inc. | Cellular therapy to heal vascular tissue |
US20060060266A1 (en) * | 2004-09-01 | 2006-03-23 | Pst, Llc | Stent and method for manufacturing the stent |
US7763067B2 (en) | 2004-09-01 | 2010-07-27 | C. R. Bard, Inc. | Stent and method for manufacturing the stent |
US20080220039A1 (en) * | 2004-09-17 | 2008-09-11 | Sherman Darren R | Thin Film Medical Devices Manufactured on Application Specific Core Shapes |
US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
EP1811933B1 (en) | 2004-09-28 | 2016-03-23 | Atrium Medical Corporation | Barrier layer |
US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
US7887579B2 (en) * | 2004-09-29 | 2011-02-15 | Merit Medical Systems, Inc. | Active stent |
US7892592B1 (en) | 2004-11-30 | 2011-02-22 | Advanced Cardiovascular Systems, Inc. | Coating abluminal surfaces of stents and other implantable medical devices |
US7632307B2 (en) * | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US20060140867A1 (en) * | 2004-12-28 | 2006-06-29 | Helfer Jeffrey L | Coated stent assembly and coating materials |
US8628565B2 (en) * | 2005-04-13 | 2014-01-14 | Abbott Cardiovascular Systems Inc. | Intravascular stent |
US7731654B2 (en) | 2005-05-13 | 2010-06-08 | Merit Medical Systems, Inc. | Delivery device with viewing window and associated method |
US7823533B2 (en) | 2005-06-30 | 2010-11-02 | Advanced Cardiovascular Systems, Inc. | Stent fixture and method for reducing coating defects |
US7735449B1 (en) | 2005-07-28 | 2010-06-15 | Advanced Cardiovascular Systems, Inc. | Stent fixture having rounded support structures and method for use thereof |
US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
US20070077435A1 (en) * | 2005-10-05 | 2007-04-05 | Schachter Deborah M | Process for coating a medical device |
US7867547B2 (en) | 2005-12-19 | 2011-01-11 | Advanced Cardiovascular Systems, Inc. | Selectively coating luminal surfaces of stents |
US8840660B2 (en) | 2006-01-05 | 2014-09-23 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
US9108217B2 (en) | 2006-01-31 | 2015-08-18 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
CA2637883C (en) * | 2006-01-31 | 2015-07-07 | Regents Of The University Of Minnesota | Electrospray coating of objects |
CA2641117C (en) * | 2006-01-31 | 2018-01-02 | Nanocopoeia, Inc. | Nanoparticle coating of surfaces |
US20070178137A1 (en) * | 2006-02-01 | 2007-08-02 | Toby Freyman | Local control of inflammation |
US8089029B2 (en) | 2006-02-01 | 2012-01-03 | Boston Scientific Scimed, Inc. | Bioabsorbable metal medical device and method of manufacture |
WO2007095466A2 (en) | 2006-02-14 | 2007-08-23 | Angiomed Gmbh & Co. Medizintechnik Kg | Highly flexible stent and method of manufacture |
US20070203564A1 (en) * | 2006-02-28 | 2007-08-30 | Boston Scientific Scimed, Inc. | Biodegradable implants having accelerated biodegradation properties in vivo |
US9622850B2 (en) | 2006-02-28 | 2017-04-18 | C.R. Bard, Inc. | Flexible stretch stent-graft |
JP2007229271A (en) | 2006-03-01 | 2007-09-13 | Tokyo Medical & Dental Univ | Bioadhesive medical device |
CA2646991A1 (en) * | 2006-03-03 | 2007-09-13 | Toho Tenax Europe Gmbh | Method for producing reinforced placed structures |
US8048150B2 (en) | 2006-04-12 | 2011-11-01 | Boston Scientific Scimed, Inc. | Endoprosthesis having a fiber meshwork disposed thereon |
US7985441B1 (en) | 2006-05-04 | 2011-07-26 | Yiwen Tang | Purification of polymers for coating applications |
US8069814B2 (en) | 2006-05-04 | 2011-12-06 | Advanced Cardiovascular Systems, Inc. | Stent support devices |
US8568764B2 (en) | 2006-05-31 | 2013-10-29 | Advanced Cardiovascular Systems, Inc. | Methods of forming coating layers for medical devices utilizing flash vaporization |
US8603530B2 (en) | 2006-06-14 | 2013-12-10 | Abbott Cardiovascular Systems Inc. | Nanoshell therapy |
US8048448B2 (en) | 2006-06-15 | 2011-11-01 | Abbott Cardiovascular Systems Inc. | Nanoshells for drug delivery |
US8246973B2 (en) | 2006-06-21 | 2012-08-21 | Advanced Cardiovascular Systems, Inc. | Freeze-thaw method for modifying stent coating |
US8017237B2 (en) | 2006-06-23 | 2011-09-13 | Abbott Cardiovascular Systems, Inc. | Nanoshells on polymers |
EP2054537A2 (en) | 2006-08-02 | 2009-05-06 | Boston Scientific Scimed, Inc. | Endoprosthesis with three-dimensional disintegration control |
WO2008034047A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Endoprosthesis with adjustable surface features |
US8057534B2 (en) | 2006-09-15 | 2011-11-15 | Boston Scientific Scimed, Inc. | Bioerodible endoprostheses and methods of making the same |
CA2663250A1 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprostheses and methods of making the same |
WO2008034048A2 (en) | 2006-09-15 | 2008-03-20 | Boston Scientific Limited | Bioerodible endoprosthesis with biostable inorganic layers |
EP2068964B1 (en) | 2006-09-15 | 2017-11-01 | Boston Scientific Limited | Medical devices and methods of making the same |
US20100016946A1 (en) * | 2006-09-18 | 2010-01-21 | C.R. Bard, Inc | Single layer eptfe and discrete bioresorbable rings |
JP2010503482A (en) | 2006-09-18 | 2010-02-04 | ボストン サイエンティフィック リミテッド | Endoprosthesis |
US9622888B2 (en) * | 2006-11-16 | 2017-04-18 | W. L. Gore & Associates, Inc. | Stent having flexibly connected adjacent stent elements |
US20080132991A1 (en) * | 2006-11-30 | 2008-06-05 | Leonard Pinchuk | Method for Ionically Cross-Linking Gellan Gum for Thin Film Applications and Medical Devices Produced Therefrom |
US9040816B2 (en) * | 2006-12-08 | 2015-05-26 | Nanocopoeia, Inc. | Methods and apparatus for forming photovoltaic cells using electrospray |
DE602007010669D1 (en) | 2006-12-28 | 2010-12-30 | Boston Scient Ltd | HREN FOR THIS |
EP2125058B1 (en) * | 2007-02-07 | 2014-12-03 | Cook Medical Technologies LLC | Medical device coatings for releasing a therapeutic agent at multiple rates |
US8333799B2 (en) * | 2007-02-12 | 2012-12-18 | C. R. Bard, Inc. | Highly flexible stent and method of manufacture |
EP2120785B1 (en) | 2007-02-12 | 2021-12-01 | C.R. Bard, Inc. | Highly flexible stent and method of manufacture |
US7938286B2 (en) * | 2007-02-13 | 2011-05-10 | Gateway Plastics, Inc. | Container system |
JP5443336B2 (en) * | 2007-04-17 | 2014-03-19 | ミセル テクノロジーズ、インコーポレイテッド | Stent with biodegradable layer |
CA2704920C (en) | 2007-06-25 | 2016-08-16 | Microvention, Inc. | Self-expanding prosthesis |
US8048441B2 (en) | 2007-06-25 | 2011-11-01 | Abbott Cardiovascular Systems, Inc. | Nanobead releasing medical devices |
US8052745B2 (en) | 2007-09-13 | 2011-11-08 | Boston Scientific Scimed, Inc. | Endoprosthesis |
WO2009051780A1 (en) * | 2007-10-19 | 2009-04-23 | Micell Technologies, Inc. | Drug coated stents |
US8211489B2 (en) * | 2007-12-19 | 2012-07-03 | Abbott Cardiovascular Systems, Inc. | Methods for applying an application material to an implantable device |
US8361538B2 (en) | 2007-12-19 | 2013-01-29 | Abbott Laboratories | Methods for applying an application material to an implantable device |
US8926688B2 (en) | 2008-01-11 | 2015-01-06 | W. L. Gore & Assoc. Inc. | Stent having adjacent elements connected by flexible webs |
KR100988816B1 (en) * | 2008-01-29 | 2010-10-20 | 신경민 | A stent |
US8196279B2 (en) | 2008-02-27 | 2012-06-12 | C. R. Bard, Inc. | Stent-graft covering process |
US7998192B2 (en) | 2008-05-09 | 2011-08-16 | Boston Scientific Scimed, Inc. | Endoprostheses |
US8236046B2 (en) | 2008-06-10 | 2012-08-07 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US7985252B2 (en) | 2008-07-30 | 2011-07-26 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis |
US8382824B2 (en) | 2008-10-03 | 2013-02-26 | Boston Scientific Scimed, Inc. | Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides |
US20100087731A1 (en) * | 2008-10-07 | 2010-04-08 | Medtronic Vascular, Inc. | Method for Tracking Degradation of a Biodegradable Stent Having Superparamagnetic Iron Oxide Particles Embedded Therein |
US20100131051A1 (en) * | 2008-11-24 | 2010-05-27 | Medtronic Vascular, Inc. | Systems and Methods for Treatment of Aneurysms Using Zinc Chelator(s) |
US20100131001A1 (en) * | 2008-11-24 | 2010-05-27 | Medtronic Vascular, Inc. | Targeted Drug Delivery for Aneurysm Treatment |
US20100152832A1 (en) * | 2008-12-12 | 2010-06-17 | Medtronic Vascular, Inc. | Apparatus and Methods for Treatment of Aneurysms With Fibrin Derived Peptide B-Beta |
WO2010101901A2 (en) | 2009-03-02 | 2010-09-10 | Boston Scientific Scimed, Inc. | Self-buffering medical implants |
US8524097B2 (en) * | 2009-03-18 | 2013-09-03 | Medtronic, Inc. | Plasma deposition to increase adhesion |
US8361334B2 (en) * | 2009-03-18 | 2013-01-29 | Medtronic, Inc. | Plasma deposition to increase adhesion |
EP2410954A4 (en) * | 2009-03-23 | 2014-03-05 | Micell Technologies Inc | Peripheral stents having layers |
WO2010111238A2 (en) * | 2009-03-23 | 2010-09-30 | Micell Technologies, Inc. | Improved biodegradable polymers |
US20100239635A1 (en) * | 2009-03-23 | 2010-09-23 | Micell Technologies, Inc. | Drug delivery medical device |
WO2010143200A2 (en) | 2009-06-11 | 2010-12-16 | Indian Institute Of Technology | A coronary stent with nano coating of drug free polymer and a process for preparation thereof |
US20100318176A1 (en) * | 2009-06-16 | 2010-12-16 | Shannon Donald T | Enhanced systems processes and associated methods for laser trimming of grafts |
DE102009037134A1 (en) * | 2009-07-31 | 2011-02-03 | Aesculap Ag | Tubular implant for replacement of natural blood vessels |
US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
US20120232640A1 (en) | 2009-11-19 | 2012-09-13 | Blue Medical Devices Bv | Narrow profile composition-releasing expandable medical balloon catheter |
EP2338534A2 (en) * | 2009-12-21 | 2011-06-29 | Biotronik VI Patent AG | Medical implant, coating method and implantation method |
EP2528537A4 (en) * | 2010-01-27 | 2016-09-07 | Vascular Therapies Inc | Device and method for preventing stenosis at an anastomosis site |
US9492652B2 (en) * | 2010-03-02 | 2016-11-15 | University Of Rochester | Implantable devices that generate low intensity electric fields for the treatment of atherosclerotic disease and prevention of ischemic vascular events and methods of manufacture |
US8668732B2 (en) | 2010-03-23 | 2014-03-11 | Boston Scientific Scimed, Inc. | Surface treated bioerodible metal endoprostheses |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
WO2012009707A2 (en) | 2010-07-16 | 2012-01-19 | Atrium Medical Corporation | Composition and methods for altering the rate of hydrolysis of cured oil-based materials |
US10058330B2 (en) | 2011-05-11 | 2018-08-28 | Microvention, Inc. | Device for occluding a lumen |
US8632847B2 (en) * | 2011-07-13 | 2014-01-21 | Abbott Cardiovascular Systems Inc. | Methods of manufacture of bioresorbable and durable stents with grooved lumenal surfaces for enhanced re-endothelialization |
WO2013152327A1 (en) | 2012-04-06 | 2013-10-10 | Merlin Md Pte Ltd. | Devices and methods for treating an aneurysm |
US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
US9895243B2 (en) | 2014-07-17 | 2018-02-20 | W. L. Gore & Associates, Inc. | Stent having adjacent elements connected by narrow flexible webs |
US10111741B2 (en) * | 2014-10-29 | 2018-10-30 | W. L. Gore & Associates, Inc. | Intralumenal stent graft fixation |
US10299948B2 (en) | 2014-11-26 | 2019-05-28 | W. L. Gore & Associates, Inc. | Balloon expandable endoprosthesis |
US10568752B2 (en) | 2016-05-25 | 2020-02-25 | W. L. Gore & Associates, Inc. | Controlled endoprosthesis balloon expansion |
US10335264B2 (en) * | 2017-03-10 | 2019-07-02 | Byung Choo Moon | Vascular graft |
EP3398620B1 (en) * | 2017-05-05 | 2022-02-23 | Dentsply IH AB | Antibacterial coating or surface comprising vertical, standing angstrom scale flakes |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5669936A (en) | 1983-12-09 | 1997-09-23 | Endovascular Technologies, Inc. | Endovascular grafting system and method for use therewith |
US4733665C2 (en) | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
US4925710A (en) | 1988-03-31 | 1990-05-15 | Buck Thomas F | Ultrathin-wall fluoropolymer tube with removable fluoropolymer core |
US5123917A (en) | 1990-04-27 | 1992-06-23 | Lee Peter Y | Expandable intraluminal vascular graft |
WO1992002345A1 (en) | 1990-08-02 | 1992-02-20 | Ronald Kempin | Chisel for dust-free chasing of brick structures |
DK0480667T3 (en) | 1990-10-09 | 1996-06-10 | Cook Inc | Percutaneous stent construction |
US5151105A (en) | 1991-10-07 | 1992-09-29 | Kwan Gett Clifford | Collapsible vessel sleeve implant |
US5395349A (en) | 1991-12-13 | 1995-03-07 | Endovascular Technologies, Inc. | Dual valve reinforced sheath and method |
US5507771A (en) | 1992-06-15 | 1996-04-16 | Cook Incorporated | Stent assembly |
US5466509A (en) | 1993-01-15 | 1995-11-14 | Impra, Inc. | Textured, porous, expanded PTFE |
WO1995005277A1 (en) | 1993-08-18 | 1995-02-23 | W.L. Gore & Associates, Inc. | A thin-wall, seamless, porous polytetrafluoroethylene tube |
JPH09501583A (en) | 1993-08-18 | 1997-02-18 | ダブリュ.エル.ゴア アンド アソシエイツ,インコーポレイティド | Tubular endoluminal implant |
US6027779A (en) | 1993-08-18 | 2000-02-22 | W. L. Gore & Associates, Inc. | Thin-wall polytetrafluoroethylene tube |
US5735892A (en) | 1993-08-18 | 1998-04-07 | W. L. Gore & Associates, Inc. | Intraluminal stent graft |
US5389106A (en) | 1993-10-29 | 1995-02-14 | Numed, Inc. | Impermeable expandable intravascular stent |
US5463010A (en) * | 1993-11-12 | 1995-10-31 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Hydrocyclosiloxane membrane prepared by plasma polymerization process |
US5443497A (en) * | 1993-11-22 | 1995-08-22 | The Johns Hopkins University | Percutaneous prosthetic by-pass graft and method of use |
US5554181A (en) * | 1994-05-04 | 1996-09-10 | Regents Of The University Of Minnesota | Stent |
US5575816A (en) * | 1994-08-12 | 1996-11-19 | Meadox Medicals, Inc. | High strength and high density intraluminal wire stent |
US5575818A (en) | 1995-02-14 | 1996-11-19 | Corvita Corporation | Endovascular stent with locking ring |
EP0810845A2 (en) | 1995-02-22 | 1997-12-10 | Menlo Care Inc. | Covered expanding mesh stent |
US6264684B1 (en) * | 1995-03-10 | 2001-07-24 | Impra, Inc., A Subsidiary Of C.R. Bard, Inc. | Helically supported graft |
US6053943A (en) * | 1995-12-08 | 2000-04-25 | Impra, Inc. | Endoluminal graft with integral structural support and method for making same |
US6124523A (en) | 1995-03-10 | 2000-09-26 | Impra, Inc. | Encapsulated stent |
JP3507503B2 (en) * | 1995-03-10 | 2004-03-15 | インプラ・インコーポレーテッド | Sealable stent for body cavity, method for producing the same, and method for introducing the same into body cavity |
US5562697A (en) | 1995-09-18 | 1996-10-08 | William Cook, Europe A/S | Self-expanding stent assembly and methods for the manufacture thereof |
US5824037A (en) | 1995-10-03 | 1998-10-20 | Medtronic, Inc. | Modular intraluminal prostheses construction and methods |
US5591195A (en) | 1995-10-30 | 1997-01-07 | Taheri; Syde | Apparatus and method for engrafting a blood vessel |
US5628788A (en) | 1995-11-07 | 1997-05-13 | Corvita Corporation | Self-expanding endoluminal stent-graft |
US5788626A (en) | 1995-11-21 | 1998-08-04 | Schneider (Usa) Inc | Method of making a stent-graft covered with expanded polytetrafluoroethylene |
US5800512A (en) | 1996-01-22 | 1998-09-01 | Meadox Medicals, Inc. | PTFE vascular graft |
US5713949A (en) | 1996-08-06 | 1998-02-03 | Jayaraman; Swaminathan | Microporous covered stents and method of coating |
US5888591A (en) | 1996-05-06 | 1999-03-30 | Massachusetts Institute Of Technology | Chemical vapor deposition of fluorocarbon polymer thin films |
US5928279A (en) * | 1996-07-03 | 1999-07-27 | Baxter International Inc. | Stented, radially expandable, tubular PTFE grafts |
WO1998012990A1 (en) * | 1996-09-26 | 1998-04-02 | Scimed Life Systems, Inc. | Support structure/membrane composite medical device |
US5858556A (en) | 1997-01-21 | 1999-01-12 | Uti Corporation | Multilayer composite tubular structure and method of making |
US5957974A (en) * | 1997-01-23 | 1999-09-28 | Schneider (Usa) Inc | Stent graft with braided polymeric sleeve |
ATE287679T1 (en) * | 1997-03-05 | 2005-02-15 | Boston Scient Ltd | COMPLIANT MULTI-LAYER STENT DEVICE |
US5851232A (en) | 1997-03-15 | 1998-12-22 | Lois; William A. | Venous stent |
US5843172A (en) * | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
US5891507A (en) | 1997-07-28 | 1999-04-06 | Iowa-India Investments Company Limited | Process for coating a surface of a metallic stent |
US6488701B1 (en) * | 1998-03-31 | 2002-12-03 | Medtronic Ave, Inc. | Stent-graft assembly with thin-walled graft component and method of manufacture |
US6129757A (en) * | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
US6245099B1 (en) * | 1998-09-30 | 2001-06-12 | Impra, Inc. | Selective adherence of stent-graft coverings, mandrel and method of making stent-graft device |
US6364903B2 (en) * | 1999-03-19 | 2002-04-02 | Meadox Medicals, Inc. | Polymer coated stent |
-
1999
- 1999-03-19 US US09/272,538 patent/US6364903B2/en not_active Expired - Lifetime
-
2000
- 2000-03-06 WO PCT/US2000/005976 patent/WO2000056247A1/en active IP Right Grant
- 2000-03-06 JP JP2000606156A patent/JP4672869B2/en not_active Expired - Fee Related
- 2000-03-06 CA CA002366665A patent/CA2366665C/en not_active Expired - Fee Related
- 2000-03-06 EP EP00917783A patent/EP1164972B1/en not_active Expired - Lifetime
- 2000-03-06 DE DE60019911T patent/DE60019911T2/en not_active Expired - Lifetime
-
2002
- 2002-02-05 US US10/067,584 patent/US6733524B2/en not_active Expired - Fee Related
-
2004
- 2004-03-24 US US10/807,700 patent/US7285132B2/en not_active Expired - Fee Related
Cited By (110)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120016457A1 (en) * | 2001-12-20 | 2012-01-19 | Trivascular2, Inc. | Barbed radially expandable stent with slotted struts |
US8864814B2 (en) * | 2001-12-20 | 2014-10-21 | Trivascular, Inc. | Method of delivering advanced endovascular graft and system |
US20120022636A1 (en) * | 2001-12-20 | 2012-01-26 | Trivascular, Inc. | Method of delivering advanced endovascular graft |
US20060206191A1 (en) * | 2002-01-04 | 2006-09-14 | Jan Weber | Non-compliant balloon with compliant top-layer to protect coated stents during expansion |
WO2003059206A1 (en) * | 2002-01-04 | 2003-07-24 | Boston Scientific Limited | Non-compliant balloon with compliant top-layer to protect coated stents during expansion |
US20170246352A1 (en) * | 2002-04-01 | 2017-08-31 | Abbott Cardiovascular Systems Inc. | Hybrid stent and method of making |
US20030208153A1 (en) * | 2002-05-03 | 2003-11-06 | Stenzel Eric B. | Method, tool, and system for deploying an implant into the body |
US20130172980A1 (en) * | 2002-05-31 | 2013-07-04 | W. L. Gore & Associates, Inc. | Implantable product with improved aqueous interface characteristics and methods for making and using the same |
US8084076B2 (en) * | 2003-02-21 | 2011-12-27 | Sorin Biomedica Cardio S.R.L. | Process for producing stents and corresponding stents |
US20080140186A1 (en) * | 2003-02-21 | 2008-06-12 | Sorin Biomedica Cardio S.R.L. | Process for producing stents and corresponding stents |
US20040230298A1 (en) * | 2003-04-25 | 2004-11-18 | Medtronic Vascular, Inc. | Drug-polymer coated stent with polysulfone and styrenic block copolymer |
US20050004653A1 (en) * | 2003-06-19 | 2005-01-06 | Scimed Life Systems, Inc. | Sandwiched radiopaque marker on covered stent |
US8021418B2 (en) | 2003-06-19 | 2011-09-20 | Boston Scientific Scimed, Inc. | Sandwiched radiopaque marker on covered stent |
US7131993B2 (en) | 2003-06-25 | 2006-11-07 | Boston Scientific Scimed, Inc. | Varying circumferential spanned connectors in a stent |
US20060129230A1 (en) * | 2003-06-25 | 2006-06-15 | Boston Scientific Scimed, Inc. | Varying circumferential spanned connectors in a stent |
US7635384B2 (en) | 2003-06-25 | 2009-12-22 | Boston Scientific Scimed, Inc. | Varying circumferential spanned connectors in a stent |
US20040267353A1 (en) * | 2003-06-25 | 2004-12-30 | Scimed Life Systems, Inc. | Varying circumferential spanned connectors in a stent |
US11375988B2 (en) | 2003-07-14 | 2022-07-05 | W. L. Gore & Associates, Inc. | Patent foramen ovale (PFO) closure device with linearly elongating petals |
US20110112629A1 (en) * | 2003-12-12 | 2011-05-12 | C. R. Bard, Inc. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
US7476246B2 (en) | 2003-12-12 | 2009-01-13 | C. R. Bard, Inc. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
US7892280B2 (en) | 2003-12-12 | 2011-02-22 | C. R. Bard, Inc. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
US20050131527A1 (en) * | 2003-12-12 | 2005-06-16 | Pathak Chandrashekhar P. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
US20090062903A1 (en) * | 2003-12-12 | 2009-03-05 | C. R. Bard, Inc. | Implantable medical devices with fluorinated polymer coatings, and methods of coating thereof |
US20140074220A1 (en) * | 2004-05-14 | 2014-03-13 | Boston Scientific Scimed, Inc. | Stent With Reduced Weld Profiles and a Closed-End Wire Configuration |
US9827117B2 (en) | 2005-07-15 | 2017-11-28 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US10898353B2 (en) | 2005-07-15 | 2021-01-26 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8298565B2 (en) | 2005-07-15 | 2012-10-30 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US8758429B2 (en) | 2005-07-15 | 2014-06-24 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US11911301B2 (en) | 2005-07-15 | 2024-02-27 | Micell Medtech Inc. | Polymer coatings containing drug powder of controlled morphology |
US10835396B2 (en) | 2005-07-15 | 2020-11-17 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US9737645B2 (en) | 2006-04-26 | 2017-08-22 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US11007307B2 (en) | 2006-04-26 | 2021-05-18 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US11850333B2 (en) | 2006-04-26 | 2023-12-26 | Micell Medtech Inc. | Coatings containing multiple drugs |
US9415142B2 (en) | 2006-04-26 | 2016-08-16 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US8852625B2 (en) | 2006-04-26 | 2014-10-07 | Micell Technologies, Inc. | Coatings containing multiple drugs |
US7988720B2 (en) | 2006-09-12 | 2011-08-02 | Boston Scientific Scimed, Inc. | Longitudinally flexible expandable stent |
US8636767B2 (en) | 2006-10-02 | 2014-01-28 | Micell Technologies, Inc. | Surgical sutures having increased strength |
US20100030261A1 (en) * | 2006-10-02 | 2010-02-04 | Micell Technologies, Inc. | Surgical Sutures Having Increased Strength |
US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
US10617795B2 (en) | 2007-01-08 | 2020-04-14 | Micell Technologies, Inc. | Stents having biodegradable layers |
US9737642B2 (en) | 2007-01-08 | 2017-08-22 | Micell Technologies, Inc. | Stents having biodegradable layers |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
US9949728B2 (en) | 2007-04-05 | 2018-04-24 | W.L. Gore & Associates, Inc. | Septal closure device with centering mechanism |
US10485525B2 (en) | 2007-04-05 | 2019-11-26 | W.L. Gore & Associates, Inc. | Septal closure device with centering mechanism |
US12059140B2 (en) | 2007-04-05 | 2024-08-13 | W. L. Gore & Associates, Inc. | Septal closure device with centering mechanism |
US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
US9486338B2 (en) | 2007-04-17 | 2016-11-08 | Micell Technologies, Inc. | Stents having controlled elution |
US9775729B2 (en) | 2007-04-17 | 2017-10-03 | Micell Technologies, Inc. | Stents having controlled elution |
US8900651B2 (en) | 2007-05-25 | 2014-12-02 | Micell Technologies, Inc. | Polymer films for medical device coating |
CN101784290B (en) * | 2007-07-05 | 2013-06-05 | Ppg工业俄亥俄公司 | Aqueous resinous binders |
WO2009006106A2 (en) * | 2007-07-05 | 2009-01-08 | Ppg Industries Ohio, Inc. | Aqueous resinous binders |
CN101784290A (en) * | 2007-07-05 | 2010-07-21 | Ppg工业俄亥俄公司 | aqueous resinous binders |
US20160158037A1 (en) * | 2008-01-29 | 2016-06-09 | Taewoong Medical Co., Ltd. | Biodegradable double stent |
US20090192588A1 (en) * | 2008-01-29 | 2009-07-30 | Taeoong Medical Co., Ltd | Biodegradable double stent |
US9474517B2 (en) | 2008-03-07 | 2016-10-25 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
US10278705B2 (en) | 2008-03-07 | 2019-05-07 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
US9789233B2 (en) | 2008-04-17 | 2017-10-17 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
US10350333B2 (en) | 2008-04-17 | 2019-07-16 | Micell Technologies, Inc. | Stents having bioabsorable layers |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9486431B2 (en) | 2008-07-17 | 2016-11-08 | Micell Technologies, Inc. | Drug delivery medical device |
US10350391B2 (en) | 2008-07-17 | 2019-07-16 | Micell Technologies, Inc. | Drug delivery medical device |
US9981071B2 (en) | 2008-07-17 | 2018-05-29 | Micell Technologies, Inc. | Drug delivery medical device |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US9856588B2 (en) | 2009-01-16 | 2018-01-02 | Zeus Industrial Products, Inc. | Electrospinning of PTFE |
US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
US10653820B2 (en) | 2009-04-01 | 2020-05-19 | Micell Technologies, Inc. | Coated stents |
US11589853B2 (en) | 2009-06-22 | 2023-02-28 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US11564672B2 (en) | 2009-06-22 | 2023-01-31 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US11596391B2 (en) | 2009-06-22 | 2023-03-07 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10792025B2 (en) | 2009-06-22 | 2020-10-06 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10806437B2 (en) | 2009-06-22 | 2020-10-20 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US20160160413A1 (en) * | 2009-08-07 | 2016-06-09 | Zeus Industrial Products, Inc. | Multilayered composite |
US11369498B2 (en) | 2010-02-02 | 2022-06-28 | MT Acquisition Holdings LLC | Stent and stent delivery system with improved deliverability |
US9687864B2 (en) | 2010-03-26 | 2017-06-27 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US11904118B2 (en) | 2010-07-16 | 2024-02-20 | Micell Medtech Inc. | Drug delivery medical device |
US10293050B2 (en) | 2010-09-09 | 2019-05-21 | Micell Technologies, Inc. | Macrolide dosage forms |
US9636309B2 (en) | 2010-09-09 | 2017-05-02 | Micell Technologies, Inc. | Macrolide dosage forms |
US9655710B2 (en) | 2011-01-28 | 2017-05-23 | Merit Medical Systems, Inc. | Process of making a stent |
US10653511B2 (en) | 2011-01-28 | 2020-05-19 | Merit Medical Systems, Inc. | Electrospun PTFE coated stent and method of use |
US10653512B2 (en) | 2011-01-28 | 2020-05-19 | Merit Medical Systems, Inc. | Electrospun PTFE coated stent and method of use |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US10729819B2 (en) | 2011-07-15 | 2020-08-04 | Micell Technologies, Inc. | Drug delivery medical device |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US9770232B2 (en) | 2011-08-12 | 2017-09-26 | W. L. Gore & Associates, Inc. | Heart occlusion devices |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
US10005269B2 (en) | 2012-01-16 | 2018-06-26 | Merit Medical Systems, Inc. | Rotational spun material covered medical appliances and methods of manufacture |
US11623438B2 (en) | 2012-01-16 | 2023-04-11 | Merit Medical Systems, Inc. | Rotational spun material covered medical appliances and methods of manufacture |
US10675850B2 (en) | 2012-01-16 | 2020-06-09 | Merit Medical Systems, Inc. | Rotational spun material covered medical appliances and methods of manufacture |
US10010395B2 (en) | 2012-04-05 | 2018-07-03 | Zeus Industrial Products, Inc. | Composite prosthetic devices |
US10507268B2 (en) * | 2012-09-19 | 2019-12-17 | Merit Medical Systems, Inc. | Electrospun material covered medical appliances and methods of manufacture |
US20140081414A1 (en) * | 2012-09-19 | 2014-03-20 | Merit Medical Systems, Inc. | Electrospun material covered medical appliances and methods of manufacture |
US11541154B2 (en) | 2012-09-19 | 2023-01-03 | Merit Medical Systems, Inc. | Electrospun material covered medical appliances and methods of manufacture |
US11771408B2 (en) | 2013-01-18 | 2023-10-03 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10828019B2 (en) | 2013-01-18 | 2020-11-10 | W.L. Gore & Associates, Inc. | Sealing device and delivery system |
US11039943B2 (en) | 2013-03-12 | 2021-06-22 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US10953586B2 (en) | 2013-03-13 | 2021-03-23 | Merit Medical Systems, Inc. | Methods, systems, and apparatuses for manufacturing rotational spun appliances |
US9827703B2 (en) | 2013-03-13 | 2017-11-28 | Merit Medical Systems, Inc. | Methods, systems, and apparatuses for manufacturing rotational spun appliances |
US10799617B2 (en) | 2013-03-13 | 2020-10-13 | Merit Medical Systems, Inc. | Serially deposited fiber materials and associated devices and methods |
US20140277381A1 (en) * | 2013-03-14 | 2014-09-18 | W. L. Gore & Associates, Inc. | Methods and apparatus for assembling stent-grafts |
US10272606B2 (en) | 2013-05-15 | 2019-04-30 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
US11298116B2 (en) | 2014-06-06 | 2022-04-12 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US9808230B2 (en) | 2014-06-06 | 2017-11-07 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10368853B2 (en) | 2014-06-06 | 2019-08-06 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
US10028852B2 (en) | 2015-02-26 | 2018-07-24 | Merit Medical Systems, Inc. | Layered medical appliances and methods |
US11026777B2 (en) | 2015-02-26 | 2021-06-08 | Merit Medical Systems, Inc. | Layered medical appliances and methods |
US10327924B2 (en) * | 2015-07-19 | 2019-06-25 | Sanford Health | Bridging stent graft with combination balloon expandable and self-expandable stents and methods for use |
US11583313B1 (en) | 2018-12-06 | 2023-02-21 | Spiway Llc | Surgical access sheath and methods of use |
US12082795B2 (en) | 2020-09-28 | 2024-09-10 | W. L. Gore & Associates, Inc. | Sealing device and delivery system |
Also Published As
Publication number | Publication date |
---|---|
US20020091437A1 (en) | 2002-07-11 |
US6364903B2 (en) | 2002-04-02 |
JP4672869B2 (en) | 2011-04-20 |
JP2002540822A (en) | 2002-12-03 |
DE60019911T2 (en) | 2006-01-26 |
US7285132B2 (en) | 2007-10-23 |
WO2000056247A1 (en) | 2000-09-28 |
EP1164972A1 (en) | 2002-01-02 |
US20040181278A1 (en) | 2004-09-16 |
EP1164972B1 (en) | 2005-05-04 |
CA2366665A1 (en) | 2000-09-28 |
US6733524B2 (en) | 2004-05-11 |
CA2366665C (en) | 2009-09-22 |
DE60019911D1 (en) | 2005-06-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6364903B2 (en) | Polymer coated stent | |
US6143022A (en) | Stent-graft assembly with dual configuration graft component and method of manufacture | |
US6488701B1 (en) | Stent-graft assembly with thin-walled graft component and method of manufacture | |
EP1093772B1 (en) | Expandable supportive bifurcated endoluminal grafts | |
JP3927545B2 (en) | Tubular PTFE graft with radially expandable stent | |
US6309413B1 (en) | Expandable supportive endoluminal grafts | |
CA2234976C (en) | Expandable supportive branched endoluminal grafts | |
US6770086B1 (en) | Stent covering formed of porous polytetraflouroethylene | |
EP0814729B1 (en) | Endoluminal encapsulated stent and methods of manufacture | |
US5749880A (en) | Endoluminal encapsulated stent and methods of manufacture and endoluminal delivery | |
EP0938879A2 (en) | Stent-graft assembly and method of manufacture | |
WO1997017913A9 (en) | Expandable supportive branched endoluminal grafts | |
AU736081B2 (en) | Expandable supportive bifurcated endoluminal grafts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: MEADOX MEDICALS, INC., NEW JERSEY Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:TSENG, DAVID;DONAHUE, WILLIAM;PARSONS, BRUCE;REEL/FRAME:009846/0692;SIGNING DATES FROM 19990302 TO 19990312 |
|
AS | Assignment |
Owner name: SCIMED LIFE SYSTEMS, MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MEADOX MEDICALS, INC.;REEL/FRAME:010656/0127 Effective date: 20000229 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FEPP | Fee payment procedure |
Free format text: PAYER NUMBER DE-ASSIGNED (ORIGINAL EVENT CODE: RMPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
AS | Assignment |
Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868 Effective date: 20050101 Owner name: BOSTON SCIENTIFIC SCIMED, INC.,MINNESOTA Free format text: CHANGE OF NAME;ASSIGNOR:SCIMED LIFE SYSTEMS, INC.;REEL/FRAME:018505/0868 Effective date: 20050101 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
AS | Assignment |
Owner name: ACACIA RESEARCH GROUP LLC, TEXAS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BOSTON SCIENTIFIC SCIMED, INC.;REEL/FRAME:030694/0461 Effective date: 20121220 |
|
AS | Assignment |
Owner name: LIFESHIELD SCIENCES LLC, TEXAS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ACACIA RESEARCH GROUP LLC;REEL/FRAME:030740/0225 Effective date: 20130515 |
|
FPAY | Fee payment |
Year of fee payment: 12 |