US20010014822A1 - Stent combination - Google Patents

Stent combination Download PDF

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Publication number
US20010014822A1
US20010014822A1 US09/727,859 US72785900A US2001014822A1 US 20010014822 A1 US20010014822 A1 US 20010014822A1 US 72785900 A US72785900 A US 72785900A US 2001014822 A1 US2001014822 A1 US 2001014822A1
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Prior art keywords
stent
tubular
arms
expanded
diamond
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Abandoned
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US09/727,859
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Simcha Milo
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Simcha Milo
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Priority to US3478796P priority Critical
Priority to US09/180,092 priority patent/US6206911B1/en
Application filed by Simcha Milo filed Critical Simcha Milo
Priority to US09/727,859 priority patent/US20010014822A1/en
Publication of US20010014822A1 publication Critical patent/US20010014822A1/en
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/848Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents having means for fixation to the vessel wall, e.g. barbs
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/075Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91508Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
    • AHUMAN NECESSITIES
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91516Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a change in frequency along the band
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91525Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other within the whole structure different bands showing different meander characteristics, e.g. frequency or amplitude
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak
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    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
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    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body

Abstract

Radially expandable intraluminal stents suitable for providing interior support within a human blood vessel are disclosed. A material used to construct the stent is formed into diamond cells. Each of the diamond cells has arms of equal length. Diamond cells are interconnected to other diamond cells by legs or to pairs of smaller cells which have a common vertex and four arms of equal length. Needle-like prongs are attached to the diamond cells at their vertex to function as attachment means for a biological membrane.

Description

  • This application claims priority from U.S. provisional application Serial No. 60/034,787, filed Dec. 19, 1996. The disclosure of this application is incorporated herein by reference. [0001]
  • This invention relates to vascular stents and the like and more particularly to intraluminal stents and to such stent and biomembrane combinations which can be carried to a desired in vivo location and then expanded, as by use of a balloon catheter, into an operative configuration. Reference is made to Disclosure Document No. 404,393 which was filed on Sep. 9, 1996. [0002]
  • BACKGROUND OF THE INVENTION
  • Expandable stents have now proved to be extremely useful in treating occluded blood vessels and/or diseased blood vessels. Whereas there are numerous expandable stents that are now commercially available, these stents invariably undergo a foreshortening in axial length as a result of their radial expansion. When treating a diseased blood vessel, and oftentimes when treating an occluded blood vessel, such as a coronary artery or other peripheral vessel, there is a desire to carry a tubular graft in surrounding relationship to the stent in order to deliver the graft with the stent to patch a diseased vascular location affected with lesions or the like. It is believed such grafts may prevent intimal cell proliferation caused by direct contact of a metal stent with the vessel wall which frequently otherwise results in early stent occlusion. Heretofore, truly acceptable techniques have not been developed for carrying such grafts to a desired location in surrounding relationship to a stent on a balloon catheter or the like. Because such present commercially available stents undergo axial foreshortening as a result of expansion, tubular grafts secured to the exterior of such a stent would be likewise subject to such foreshortening and would undergo undesirable wrinkling even if they were slightly elastic. [0003]
  • SUMMARY OF THE PRESENT INVENTION
  • The present invention provides multiple designs of expandable stents which are created so as to undergo essentially no axial foreshortening (or only minimal axial foreshortening) when expanded from an unexpanded or compressed configuration to an operative configuration. Moreover, tubular biological membranes can now be effectively interconnected with expandable stents of this character and effectively located in surrounding, isolating relationship to the stent. Interconnection may be via pairs of needle-like projections or prongs which may be bent to have a radial orientation during the installation of such a tubular biomembrane upon the unexpanded stent and then bent in opposite directions back into the plane of the stent, preferably in opposite axially extending directions, to secure the tubular biomembrane in such a mating connection. [0004]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a plan view of an expanded form of stent material before it is rolled and welded into a tubular stent and then appropriately crimped, which material design is effective to create a particularly advantageous crimped stent. [0005]
  • FIG. 2 is a view similar to FIG. 1 illustrating an alternative material design to that shown in FIG. 1 which alternative employs pairs of small diamond cells. [0006]
  • FIG. 3 shows a further alternative material design that constitutes a hybrid version of the two materials shown in FIGS. 1 and 2. [0007]
  • FIG. 4 is a view similar to FIG. 1 which is another alternative material design similar to that shown in FIG. 3 but which incorporates needle-like projections that extend in opposite longitudinal directions and that are employed to mount a tubular biological membrane exterior of the stent. [0008]
  • FIG. 5 is a fragmentary elevation view of the stent material illustrated in FIG. 1 shown in its crimped condition. [0009]
  • FIG. 5A is a fragmentary elevation view of the stent material illustrated in FIG. 3 shown in its crimped condition. [0010]
  • FIG. 6 is a perspective view of a tubular stent made from the material of FIG. 4 shown in its expanded configuration. [0011]
  • FIG. 7 is a fragmentary sectional view through a crimped tubular stent made from material shown in FIG. 4 with a tubular membrane mounted in place and in the process of being staked thereupon, with the radially outwardly bent needle-like prongs being shown as they are in various stages of being bent back toward the plane of the stent. [0012]
  • FIG. 8 is a sectional view similar to FIG. 7 showing an alternative method of joining a tubular membrane to a crimped stent by folding each end of the tubular stent back upon itself to securely sandwich the ends of the tubular membrane therebetween. [0013]
  • DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The stents of the invention are provided with properties which render them superior to commercially available expandable intraluminal stents. The stents illustrated herein not only experience substantially no shortening in axial length upon expansion but also demonstrate high lateral pliability, allowing the stent to relatively easily follow the curved features of a blood vessel or the like as it is being inserted on a balloon catheter or the like. Both of these objectives are achieved while at the same time providing good radial support, sufficient to withstand the tendency of a blood vessel that has been ballooned to recoil to a smaller diameter. Such radial support remains a characteristic even though the stent may have been radially expanded to increase its unexpanded or crimped diameter by a factor of about 2 to 4, e.g. from a crimped exterior diameter of about 1.3-1.5 mm or even as low as 1.1 mm. [0014]
  • In addition, the stents of the invention can be advantageously employed in combination with tubular, biological membranes, sometimes referred to as biomembranes, which will serve to separate the major portion of the metal material of the stent from the vascular wall and thus obviate reocclusion secondary to intimal cell proliferation. Biomembranes can also be valuable in repairing blood vessels in certain diseased states, as for example those which are torn or have suffered the results of affection with different lesions or the like. Impregnation of the exterior surface and the interior surface of biomembranes with different pharmaceuticals can be effectively used to differentially deliver medications. These stent biomembrane combinations can be carried to the desired location in a patient upon a balloon catheter and then expanded to just the desired diameter by the careful expansion of the balloon catheter. As a result, these stents have a substantial advantage in flexibility of usage over self-expanding stents which may inherently continue to expand past the desired diameter, resulting in their becoming undesirably deeply embedded in the vessel wall. Because the stents of the present invention do not significantly decrease in axial length upon expansion, they are perfectly suited for use in combination with biological membranes which are pliable and slightly stretchable and elastic. [0015]
  • Illustrated in FIG. 1 is a generally rectangular piece or blank of malleable metal sheet [0016] 11 which represents an expanded framework of an approximate shape for being rolled, welded (or otherwise joined) and crimped to create a balloon-expandable stent. By malleable is meant a non-brittle, pliable metal that can be bent to a different shape but which has sufficient stability so as to retain its expanded shape when subjected to the normal forces that may likely be encountered within the human body. The illustrated stent blank 11 is constructed with an open framework which includes a plurality of axially extending legs which have a zig-zag configuration and which are formed by interconnected leg segments 13. Each junction between adjacent legs in the framework is also the vertex of a diamond-shaped cell 17. Each of the cells 17 is made up of four interconnected arms 19, and thus the cells 19 serve as spacers which uniformly space apart the adjacent, axially-extending, zig-zag legs. Viewed from a different perspective, the open framework material has a construction in the form of side-by-side axially extending rows of major diamond-shaped cells with the adjacent rows being staggered so as to interfit and create a regular pattern. The result of such overlapping is that each of these major cells would include two spaced-apart minor diamond cells 17 along with pairs of flanking leg segments 13.
  • The stent material may be made from flat wire that is welded or suitably joined at the points of contact; however, it is preferably made by suitably machining a sheet of malleable metal, such as titanium, stainless steel or other suitable metal alloy material. Wire or sheets of a memory-type nickel alloy, such as Nitinol, might also be used. Such could be shaped and then welded to create a tubular structure of desired diameter and length, and such a tubular structure might then be cooled below the temperature transformation level and suitably compressed before being loaded into a catheter. [0017]
  • When a sheet of nonmemory malleable metal is used, suitable openings are formed in such a sheet by conventional laser-cutting techniques or by electrical discharge machining or the like. Such an open framework may alternatively be machined from a thin metal tube, seamless or welded, although more sophisticated equipment might be required to machine a tubular body. Thus, stents may be preferably made from a flat sheet, as depicted in FIG. 1, which is subsequently rolled into a tubular configuration (which would be about a horizontal axis as oriented in FIG. 1) and then welded or otherwise appropriately fusion-bonded. For example, it may be made from a sheet of stainless steel having a thickness of about 0.08 mm to about 0.1 mm. The leg segments preferably have a width at least about 40% greater than the width of the arms of the cells. For example, the arms may have a width of about 0.05 mm, with the leg segments having a width of about 0.075 mm. The machined sheet would be finally polished as well known in this art. [0018]
  • More specifically, each of the diamond-shaped cells [0019] 17 has four arms 19 of preferably equal length which are connected to one another at their ends to form a diamond which, in the expanded configuration, as illustrated in FIG. 1, has four interior 90° angles. The aforementioned major diamond cells 17 of the overall repeating pattern are formed by two adjacent arms of each cell 17, together with two pairs of interconnected leg segments 13. Following rolling or otherwise forming into tubular configuration, a spot-welding operation is carried out to connect the vertices A of each diamond cell 15 located along the top edge of the generally rectangularly-shaped piece of material 11 to the junction points between adjacent leg segments 13 that are located along the bottom edge, i.e. at the locations marked B. This diamond-within-a-diamond pattern allows for compression or crimping of the framework to a smaller dimension, e.g. about one-half of the height shown in FIG. 1, without any substantial change in axial length.
  • When the stent is machined from flat metal stock, the tubular framework configuration may first be formed and then compressed to create a smaller diameter tubular structure. The leg segments [0020] 13 in the zig-zag, axially extending legs are oriented so as to be at an angle to each other of between about 120° and 140° and preferably at an angle of between about 125° and 135°. In viewing the framework shown in FIG. 1, it can be seen that each leg segment 13 ends at a junction point where it is in connection with two arms 19 of a diamond-shaped cell and the next adjoining leg segment 13. As a result, there is good stabilizing support at these locations. At the other two vertices of each diamond cell 17 that are not at junctions between leg segments, there is no lateral support. As a result, when the open framework structure is subjected to crimping or compressing force, the diamond-shaped cells 17 collapse in a direction transverse to the axis, significantly reducing the circumference of the tubular structure.
  • FIG. 5 is a fragmentary view of a stent made from the material [0021] 11 shown in its compressed condition, where it can be seen that the triangular cells 17 have completely collapsed. The arms 19 of the diamond cells 17 lie adjacent to each other in pairs. The zig-zag configuration of the legs has now reversed, i.e. compared to the orientation in the expanded configuration illustrated in FIG. 1, the orientation is the inverse of what it was. However, the leg segments 13 are still oriented at about the same angle to each other. The collapsing of the diamond-shaped cells 17 has no effect upon the axial length of the tubular structure because they are isolated from the legs, and there is no significant change in the axial length of the stent in its unexpanded and expanded configurations. However, a slight extension in length occurs during transition when the adjacent leg segments approach an angle of 180°.
  • Illustrated in FIG. 2 is an alternative embodiment of a piece or blank of sheet material [0022] 23 similarly designed to be formed into an expandable intraluminal stent. The material also uses a type of general pattern of a diamond-in-a-diamond; however, in this repeating pattern, axially extending legs that are formed by short leg segments 25, are spaced apart not by single minor diamond cells, but by pairs of diamond cells 27 having a common vertex. The material 23 can likewise be made by machining from a single sheet. Alternatively, it could be formed from a plurality of individual wire sections, each of which would ultimately run circumferentially of the tubular stent. As depicted in FIG. 2, if such lengths of wire were used, adjacent, vertically oriented, formed lengths of wire would be joined, as by spot-welding, at three points. As indicated hereinbefore, the framework material is preferably machined from a unitary sheet or tube, and to achieve more efficient use of material, the structure is machined in the unexpanded form which also eliminates the step of crimping or compressing.
  • The open framework structure shown in FIG. 2 is such that each of the diamond cells of the interconnected pairs has a common vertex [0023] 31 and an opposite open vertex 32 which lies at what would otherwise be the junction between the ends of the adjacent leg segments 25. As a result, the leg segments 25, instead of being directly connected to one another at these junctions, are indirectly connected through the arms 29 of one of the diamond cells 27. Even though they are not directly interconnected, the leg segments 25 are still oriented at an angle to each other between about 120° and about 140° as mentioned above. Following rolling of the material 23 or otherwise forming it into a tubular configuration, spot welding or the like is carried out so as to join the ends of the arms 29 at each open vertex along the upper edge of the sheet, at the points marked A, by spot welding or the like, to the ends of the leg segments 25 at the points marked B.
  • Illustrated in FIG. 3 is a further alternative embodiment of a piece or blank of sheet material [0024] 33, designed to be formed into an expandable intraluminal stent, having a structure which is a hybrid of those shown in FIGS. 1 and 2. The material 33 uses alternating sections of the FIG. 1 material and the FIG. 2 material. In a center section and the two lateral edge sections, larger diamond cells 35 are formed, similar to the cells 17. Each of these diamond cells 35 has four arms 37 of equal length, and the upper and lower vertices are located at junctions between adjacent interconnected leg segments or ribs 39. The two intermediate regions resemble the framework construction shown in FIG. 2. Pairs of smaller diamond cells 41 with a common vertex and four arms 43 of equal length indirectly interconnect leg segments 39 a at the locations of the open vertices.
  • The blank [0025] 33 is used to form a stent as previously described by rolling or otherwise deforming it into a tubular form and then spot-welding or the like at the aligned points between the two common axially extending edges. After formation into such a tube, it is conventionally crimped as by being forced axially through a tubular passageway of ever-decreasing diameter to effect such a smooth transition from the expanded, highly open framework to a fairly closely compressed cylindrical form, such as that depicted in the fragmentary view FIG. 5A. The arms 37 which make up the larger diamond cells 35 lie generally adjacent one another in pairs. Likewise, the arms 43 of the smaller diamond cells 41 are similarly compressed so as to lie adjacent one another, as shown in the left-hand portion of FIG. 5A.
  • In the expanded material shown in FIG. 3, the leg segments [0026] 39 and 39 a are oriented at an angle of between 125° to 135° to each other, which would be the “internal” angle in the major diamond pattern as described hereinbefore. During crimping, these two pairs of leg segments 39, 39 a pass through an angle of orientation to each other of 180°. Following the completion of crimping, the same two leg segments are still oriented at about an angle of about 125° to about 135° to each other; however, now that angle is on the exterior of what was once the major diamond cell in the expanded configuration. What was once the internal angle is now the inverse of that angle. For example, if the interconnected leg segments in the major cells were oriented at an interior angle of about 130° to each other, that “interior” angle would now be about 230° in the crimped configuration, as can be seen in FIG. 5. However, because the relative angular orientation of the individual leg segments to one another is still the same, i.e. about 130°, in both the expanded and the unexpanded configurations of the stent, the axial length of the legs has not changed; thus, the length of the stent in its crimped condition is substantially the same as the length of the stent in its expanded configuration. It can of course be seen that the expansion/compression of the diamond cells 35 and 41 has no effect upon the axial length of the stent, whereas it provides the major amount of the circumferential dimensional change.
  • Shown in FIG. 4 is a piece or blank of stent material [0027] 33′ which is essentially the same construction as the material 33 with the exception that a plurality of pairs of oppositely extending needle-like projections or prongs 51 and 53 are included. These projections are located so they are encompassed within what has sometimes been termed the major diamond cells, and they are oriented axially, i.e. they will lie parallel to the longitudinal axis of the fabricated tubular stent body. The projections 51 and the projections 53 extend in opposite directions and are used to affix a tubular biological membrane to the stent so that such a membrane can be transported in surrounding relationship about a crimped stent to a desired location within a diseased artery or the like. Once so located and following radial expansion of the stent, this biomembrane will serve to provide a smooth interface between the diseased or torn (dissected) wall of the artery and the stent itself, thus isolating the major portion of the metal stent from the intima. In this form, the stent combination can simultaneously deal with two major and critical problems of coronary or other occlusive disease. Tubular biological membranes that are frequently employed as blood vessel substitutes are available from various sources, such as Shellhigh, Inc. of Millbourne, N.J., USA; they are typically given a tissue preservation treatment, such that as offered by Shellhigh as its No-React™ treatment. Such treatments are commonly known in this art and may be employed to “fix” the tissue, i.e. to cross-link the collagenaceous chains of the tissue to give it increased strength, and also to endow the tissue with some resistance to calcification. Mammary and other blood vessels from animals of the bovine and porcine species, for example, are available and frequently employed for such blood vessel substitutes; they will serve as suitable biomembranes for the present invention. There may be advantages in affixing the untreated blood vessels following harvesting, and then treating the blood vessel as it has a tendency to shrink during fixation. This will cause the treated vessel to lie close to the surface of the stent within the catheter sheath; however, such biological membrane will stretch along with the expansion of the stent without tearing. In addition to the aforementioned stabilizing treatments, these biomembranes may be used to carry and deliver different classes of medications from the interior and the exterior surfaces. For example, the intima may be medicated by impregnating the exterior surface with an antiproliferative medication, such as is well known in this art, which would serve to avoid rapid growth of the adjacent tissue of the living blood vessel in which the stent-biomembrane combination is being placed. At the same time, the interior surface of the biomembrane might be impregnated with pharmaeuticals that are released slowly into the bloodstream; examples include antithrombotic agents, such as heparin and salicilates, thrombolytic drugs, such as TPA, SK (streptokinase) and Reopro™, and slow-releasing gene therapy molecules which stimulate rebuilding of new blood vessels, i.e. neovascular proliferation.
  • Illustrated in FIG. 6 is a fragmentary perspective view of a stent fabricated from the material illustrated in FIG. 4. In this tubular configuration, the prongs [0028] 57, 53 are oriented axially of the tubular open framework so that the distance between the adjacent prongs does not change as a result of expansion/compression of the stent. FIG. 6 of course illustrates-the stent in its expanded configuration which would occur within the blood vessel, and the tubular biomembrane would be installed about the stent when it is in its compressed or unexpanded condition as explained hereinafter.
  • Illustrated in FIG. 7 a fragmentary sectional view of a crimped tubular stent made from the material [0029] 33′ which shows a biological membrane 57′ that is punctured by the pairs of needle-like prongs 51, 53 which are bent radially outward for the installation of the biomembrane. The biomembrane 57 is installed over these radially oriented projections and aligned so that there is generally no slack in the membrane longitudinally. There could be shallow folds of membrane between axial rows of pairs of prongs, or the biomembrane could have shrunk to a diameter close to that of the compressed stent. Precise radial cuts are preferably made in the tubular membrane at the sites where the prongs will penetrate the membrane so there will be no local tearing. Once the membrane is in place, the tips of the projections 51 and 53 may optionally be bent in the appropriate directions to create short tangs 55, as shown on three of the four projections in FIG. 6. The prongs 51 are then bent to the right, as shown in two different stages, until they again lie essentially in the plane of the tubular stent. The projections 53, with their tips bent in the opposite direction to form tangs 55, are then bent to the left to the orientation as shown in one instance so as to firmly secure the biological membrane 57 to the stent with the tangs embedded in the surface. Thereafter, upon circumferential expansion of the tubular stent within the blood vessel of a patient, the biological membrane becomes spread out and/or stretches tautly on the exterior surface of the expanded stent with no folds or wrinkles because of the fact that the axial length of the stent does not shorten during its transition to the expanded condition, having substantially the same length as in the crimped configuration. Such biological membranes have considerable stretchability, as mentioned hereinbefore, so the slight axial expansion that occurs when the leg segments pass through an angular orientation of 180° during expansion creates no difficulty.
  • Illustrated in FIG. 7 is an alternative method of joining a tubular biological membrane [0030] 57 to a stent which can be effectively carried out using stent material that does not become foreshortened upon expansion. The stent material, for example, can be any of the constructions shown in FIGS. 1, 2 or 3. The stent material is formed into its tubular condition, and then the tubular biological membrane is installed in place regularly surrounding the stent which is in the compressed configuration, with the tubular membrane 57 being slightly shorter than the stent so as to leave a short margin at each axial end. Each end 61 of the stent is first flared outward and then folded back upon itself so as to sandwich each end of the tubular membrane 57 between two layers of stent material. Because of the relatively open pattern at each end of the stent, each end of the tubular membrane 57 becomes well secured by this folding and crimping of the malleable metal stent material at spaced apart locations which might lie between shallow folds in the membrane. Thus, the biological membrane 57 can be effectively carried in place as part of such a stent combination, and upon expansion of the stent by an interior balloon catheter or the like, it provides a tubular support structure with a biological membrane smoothly disposed about its entire exterior circumference.
  • Although the invention has been described in terms of its preferred embodiments which constitute the best mode presently envisioned by the inventor for carrying out the invention, it should be understood that various changes and modifications as would be obvious to one having ordinary skill in this art, may be made without departing from the scope of the invention which is defined by the appended claims. In this respect, whereas the materials from which the stents are preferably constructed are primarily illustrated in their expanded conditions, it should be understood that they may be laser-cut or otherwise suitably machined from malleable sheet or tube material in their compressed or unexpanded condition and suitably polished in this configuration to render them ready for installation in a human body. Moreover, it may be preferable to machine them from a tube of intermediate diameter and polish the tubular stent in such a partially expanded state prior to crimping. The medications with which such biological membrane may be impregnated may be designed for fairly immediate release, or for slow release over a predetermined period of time, and different classes of medications can be carried by the interior and the exterior of a biological membrane in the form of a mammalian blood vessel. Whereas the exterior surface may be impregnated with well known anti-proliferative compounds to prevent local intimal proliferation, the interior surface may be impregnated with thrombolytic agents, such as TPA, SK and urokinase, or with antithrombotic agents, such as heparin and salicitates, or with gene therapy molecules designed to promote neovascularization. [0031]
  • Particular features of the invention are emphasized in the claims which follow. [0032]

Claims (20)

What is claimed is:
1. An intraluminal stent which is radially expandable to an operative configuration in which it provides interior support for a blood vessel, which stent comprises
a tubular structure capable of being radially expanded from a smaller diameter unexpanded configuration to a larger diameter expanded configuration without substantially any shortening of its axial length,
said structure being formed of a malleable material which in its expanded configuration will effectively resist return to a smaller diameter condition when subject to normal forces acting within the body of a mammal,
said structure constituting an open framework which includes a plurality of axially extending leg means that extend from one axial end to the other of said tubular structure,
said leg means each including a plurality of leg segments which are interconnected with one another at an angle of between about 120° and 140° in a zig-zag pattern, and
said legs being spaced apart from one another by a plurality of spacers which include open diamond-shaped cells, each of said cells being connected at at least one vertex to at least one of said legs.
2. The stent according to
claim 1
wherein said adjacent leg segments are oriented at an angle of between about 125° and about 135° to each other both in said unexpanded configuration and in said expanded configuration.
3. The stent according to
claim 1
wherein each of said cells includes four arms having approximately the same length and width as one another.
4. The stent according to
claim 3
wherein the width of said leg segments is at least about 40% greater than the width of said arms.
5. The stent according to
claim 1
wherein said spacers each comprise a pair of diamond-shaped cells which each have four arms and a common vertex, said pair being aligned transverse to the axis of said tubular structure.
6. The stent according to
claim 5
wherein said arms all have about the same length.
7. The stent according to
claim 6
wherein the width of said leg segments is at least about 40% greater than the width of said arms.
8. The stent according to
claim 1
wherein each of said adjacent leg segments is joined at its end to the end of one of said arms of said cells and is spaced apart from the end of said adjacent leg segment.
9. An intraluminal stent which is radially expandable to an operative configuration in which it provides interior support for a blood vessel, which stent comprises
a tubular structure capable of being radially expanded from a smaller diameter unexpanded configuration to a larger diameter expanded configuration without substantially shortening its axial length,
said structure being formed of a malleable material which in its expanded configuration will effectively resist return to a smaller diameter condition when subject to normal forces acting within the body of a mammal,
said structure being an open unitary framework which includes a plurality of axially extending legs which extend from one axial end to the other of said tubular structure, and
adjacent of said legs being spaced apart from each other by a plurality of spacers which include open diamond-shaped cells connected at vertices to said adjacent legs.
10. The stent of
claim 9
wherein said legs comprise a plurality of leg segments which are directly joined end-to-end so that each leg constitutes a continuous zig-zag line.
11. The stent of
claim 9
wherein each said leg segment terminates in a unitary junction to an adjacent leg segment and to one vertex of one of said diamond cells.
12. The stent of
claim 11
wherein each said junction joins two said leg segments and two arms which constitute one-half of one of said diamond-shaped cells, with said leg segments having a width at least about 40% greater than said arms.
13. The stent of
claim 12
wherein the opposite end of each of said arms to that which is joined at each said junction is connected only to another arm of said diamond-shaped cell so that, when said stent is transformed between its unexpanded and its expanded configurations, said two connected arms are bent from a generally parallel orientation to a generally perpendicular orientation.
14. The stent of
claim 13
wherein the angular orientation of said adjacent leg segments is between about 120° and about 140° in both the expanded and unexpanded configurations.
15. The combination of the stent of
claim 12
and a tubular biological membrane in the form of a mammalian blood vessel segment wherein said tubular structure includes a plurality of prongs which are connected to various of said junctions and aligned axially in regions between adjacent legs and which prongs can be bent to a generally radial orientation to permit the attachment of said blood vessel segment in surrounding relationship, said prongs protruding through said blood vessel segment wall and being aligned in an axial orientation to secure said blood vessel segment thereto.
16. A product for repairing an injured or diseased blood vessel or other bodily conduit, which product comprises the combination of
a tubular biomembrane and
an expandable tubular stent having a cross-sectional size less than that of said biomembrane and having means to secure said biomembrane in surrounding relationship thereto,
said stent being constructed of a unitary open framework which does not substantially change in axial length when expanded from its unexpanded to its expanded configuration so that said tubular biomembrane lies tautly upon the exterior surface of said expanded stent.
17. The product according to
claim 16
wherein said biomembrane is a mammalian blood vessel segment which has been treated with a preservation process so as to cross-link the collagenous chains thereof to increase the structural strength thereof and to provide resistance to calcification.
18. The product according to
claim 17
wherein the exterior surface of said tubular biomembrane is impregnated with a medication which prevents local intimal proliferation and the interior surface thereof is impregnated with a different pharmaceutical for slow release into the bloodstream.
19. The product according to
claim 16
wherein said tubular framework includes a plurality of bendable prongs extending generally axially of said stent and penetrating through said biomembrane, said prongs extending in axially opposite directions, each of which prongs has a radially inwardly directed tang at its free end.
20. The product according to
claim 16
wherein said tubular framework is bent back upon itself at each axial end to sandwich spaced apart regions of said tubular biomembrane therebetween.
US09/727,859 1996-12-19 2000-12-01 Stent combination Abandoned US20010014822A1 (en)

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040093072A1 (en) * 2002-05-06 2004-05-13 Jeff Pappas Endoprosthesis for controlled contraction and expansion
US20040093073A1 (en) * 2002-05-08 2004-05-13 David Lowe Endoprosthesis having foot extensions
US20050107865A1 (en) * 2003-05-06 2005-05-19 Anton Clifford Endoprosthesis having foot extensions
FR2865926A1 (en) * 2004-02-11 2005-08-12 Perouse Laboratoires Tubular prosthesis e.g. stent, for treating blood vessel e.g. vein, has three clamps regularly and angularly distributed at its periphery, where each clamp has two hooks movable between deployed and closure positions
US20060015173A1 (en) * 2003-05-06 2006-01-19 Anton Clifford Endoprosthesis having foot extensions
US20070021834A1 (en) * 2003-05-06 2007-01-25 Eugene Young Endoprosthesis having foot extensions
US20100318181A1 (en) * 1998-12-11 2010-12-16 Endologix, Inc. Implantable vascular graft
KR101055157B1 (en) * 2003-02-25 2011-08-08 코디스 코포레이션 Having a superposition type finger for reinforcing the blood vessel stent protection
WO2015114463A3 (en) * 2014-02-02 2016-03-03 Gil Hefer Apparatus and methods for recannalization, valve repair and replacement

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070073384A1 (en) * 1995-03-01 2007-03-29 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US7988720B2 (en) 2006-09-12 2011-08-02 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US7204848B1 (en) 1995-03-01 2007-04-17 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US20040106985A1 (en) * 1996-04-26 2004-06-03 Jang G. David Intravascular stent
JP4636634B2 (en) * 1996-04-26 2011-02-23 ボストン サイエンティフィック サイムド,インコーポレイテッドBoston Scientific Scimed,Inc. Intravascular stent
US6241760B1 (en) * 1996-04-26 2001-06-05 G. David Jang Intravascular stent
US6152957A (en) * 1996-04-26 2000-11-28 Jang; G. David Intravascular stent
US6330884B1 (en) * 1997-11-14 2001-12-18 Transvascular, Inc. Deformable scaffolding multicellular stent
ES2251763T3 (en) * 1997-01-24 2006-05-01 Paragon Intellectual Properties, Llc Bistable spring structure for an endoprosthesis.
US8663311B2 (en) * 1997-01-24 2014-03-04 Celonova Stent, Inc. Device comprising biodegradable bistable or multistable cells and methods of use
US8353948B2 (en) * 1997-01-24 2013-01-15 Celonova Stent, Inc. Fracture-resistant helical stent incorporating bistable cells and methods of use
CA2241558A1 (en) * 1997-06-24 1998-12-24 Richard T. Allen Stent with reinforced struts and bimodal deployment
US6235053B1 (en) * 1998-02-02 2001-05-22 G. David Jang Tubular stent consists of chevron-shape expansion struts and contralaterally attached diagonal connectors
EP1059896B1 (en) * 1998-03-04 2006-05-24 Boston Scientific Limited Improved stent cell configurations
US7500988B1 (en) * 2000-11-16 2009-03-10 Cordis Corporation Stent for use in a stent graft
US6942692B2 (en) * 2000-11-16 2005-09-13 Cordis Corporation Supra-renal prosthesis and renal artery bypass
US7229472B2 (en) * 2000-11-16 2007-06-12 Cordis Corporation Thoracic aneurysm repair prosthesis and system
EP1126795A2 (en) * 1998-11-06 2001-08-29 St. Jude Medical Cardiovascular Group, Inc. Medical graft connector component and methods of making and installing same
GB2344053A (en) 1998-11-30 2000-05-31 Imperial College Stents for blood vessels
US6712836B1 (en) 1999-05-13 2004-03-30 St. Jude Medical Atg, Inc. Apparatus and methods for closing septal defects and occluding blood flow
US20010047200A1 (en) * 1999-10-13 2001-11-29 Raymond Sun Non-foreshortening intraluminal prosthesis
US6315708B1 (en) * 2000-03-31 2001-11-13 Cordis Corporation Stent with self-expanding end sections
US7766956B2 (en) * 2000-09-22 2010-08-03 Boston Scientific Scimed, Inc. Intravascular stent and assembly
US6485508B1 (en) * 2000-10-13 2002-11-26 Mcguinness Colm P. Low profile stent
US6799637B2 (en) 2000-10-20 2004-10-05 Schlumberger Technology Corporation Expandable tubing and method
WO2002038080A2 (en) * 2000-11-07 2002-05-16 Advanced Bio Prosthetic Surfaces, Ltd. Endoluminal stent, self-fupporting endoluminal graft and methods of making same
US6506211B1 (en) * 2000-11-13 2003-01-14 Scimed Life Systems, Inc. Stent designs
NO335594B1 (en) * 2001-01-16 2015-01-12 Halliburton Energy Serv Inc Expandable devices and methods for these
US7125420B2 (en) * 2002-02-05 2006-10-24 Viacor, Inc. Method and apparatus for improving mitral valve function
US7052487B2 (en) * 2001-10-26 2006-05-30 Cohn William E Method and apparatus for reducing mitral regurgitation
CA2441370C (en) * 2001-03-05 2011-05-24 Viacor, Incorporated Apparatus and method for reducing mitral regurgitation
US6602283B2 (en) * 2001-04-06 2003-08-05 Scimed Life Systems, Inc. Stent design
US7338514B2 (en) 2001-06-01 2008-03-04 St. Jude Medical, Cardiology Division, Inc. Closure devices, related delivery methods and tools, and related methods of use
US20060136053A1 (en) * 2003-05-27 2006-06-22 Rourke Jonathan M Method and apparatus for improving mitral valve function
US6939369B2 (en) * 2002-04-03 2005-09-06 Cook Incorporated Intraluminal graft assembly and vessel repair system
US7976564B2 (en) 2002-05-06 2011-07-12 St. Jude Medical, Cardiology Division, Inc. PFO closure devices and related methods of use
JP4481559B2 (en) * 2002-09-30 2010-06-16 テルモ株式会社 Indwelling stent and stent delivery system
US7223283B2 (en) * 2002-10-09 2007-05-29 Boston Scientific Scimed, Inc. Stent with improved flexibility
US8105373B2 (en) 2002-12-16 2012-01-31 Boston Scientific Scimed, Inc. Flexible stent with improved axial strength
US7918884B2 (en) 2003-02-25 2011-04-05 Cordis Corporation Stent for treatment of bifurcated lesions
US20040267306A1 (en) 2003-04-11 2004-12-30 Velocimed, L.L.C. Closure devices, related delivery methods, and related methods of use
WO2004112615A2 (en) 2003-06-16 2004-12-29 Galdonik Jason A Temporary hemostatic plug apparatus and method of use
US7131993B2 (en) * 2003-06-25 2006-11-07 Boston Scientific Scimed, Inc. Varying circumferential spanned connectors in a stent
US20040267349A1 (en) 2003-06-27 2004-12-30 Kobi Richter Amorphous metal alloy medical devices
US7381219B2 (en) 2003-12-23 2008-06-03 Sadra Medical, Inc. Low profile heart valve and delivery system
US8998973B2 (en) * 2004-03-02 2015-04-07 Boston Scientific Scimed, Inc. Medical devices including metallic films
US8591568B2 (en) * 2004-03-02 2013-11-26 Boston Scientific Scimed, Inc. Medical devices including metallic films and methods for making same
US20140107761A1 (en) 2004-07-26 2014-04-17 Abbott Cardiovascular Systems Inc. Biodegradable stent with enhanced fracture toughness
US7901447B2 (en) * 2004-12-29 2011-03-08 Boston Scientific Scimed, Inc. Medical devices including a metallic film and at least one filament
US8632580B2 (en) * 2004-12-29 2014-01-21 Boston Scientific Scimed, Inc. Flexible medical devices including metallic films
US8992592B2 (en) 2004-12-29 2015-03-31 Boston Scientific Scimed, Inc. Medical devices including metallic films
US20060142838A1 (en) * 2004-12-29 2006-06-29 Masoud Molaei Medical devices including metallic films and methods for loading and deploying same
US20080275550A1 (en) * 2006-02-24 2008-11-06 Arash Kheradvar Implantable small percutaneous valve and methods of delivery
US7331991B2 (en) 2005-02-25 2008-02-19 California Institute Of Technology Implantable small percutaneous valve and methods of delivery
US7780724B2 (en) * 2006-02-24 2010-08-24 California Institute Of Technology Monolithic in situ forming valve system
US7854760B2 (en) * 2005-05-16 2010-12-21 Boston Scientific Scimed, Inc. Medical devices including metallic films
US7476245B2 (en) * 2005-08-16 2009-01-13 Advanced Cardiovascular Systems, Inc. Polymeric stent patterns
US8206428B2 (en) 2005-09-02 2012-06-26 Medtronic Vascular, Inc. Tabbed stent with minimum compressed profile
US20070156230A1 (en) 2006-01-04 2007-07-05 Dugan Stephen R Stents with radiopaque markers
US8747879B2 (en) 2006-04-28 2014-06-10 Advanced Cardiovascular Systems, Inc. Method of fabricating an implantable medical device to reduce chance of late inflammatory response
US7971333B2 (en) 2006-05-30 2011-07-05 Advanced Cardiovascular Systems, Inc. Manufacturing process for polymetric stents
US7731890B2 (en) 2006-06-15 2010-06-08 Advanced Cardiovascular Systems, Inc. Methods of fabricating stents with enhanced fracture toughness
WO2008091493A1 (en) * 2007-01-08 2008-07-31 California Institute Of Technology In-situ formation of a valve
US8303644B2 (en) * 2007-05-04 2012-11-06 Abbott Cardiovascular Systems Inc. Stents with high radial strength and methods of manufacturing same
US8388673B2 (en) * 2008-05-02 2013-03-05 Abbott Cardiovascular Systems Inc. Polymeric stent
US8002817B2 (en) * 2007-05-04 2011-08-23 Abbott Cardiovascular Systems Inc. Stents with high radial strength and methods of manufacturing same
US9144508B2 (en) * 2007-07-19 2015-09-29 Back Bay Medical Inc. Radially expandable stent
US8876897B2 (en) * 2007-12-20 2014-11-04 Arash Kheradvar Implantable prosthetic valves and methods relating to same
AU2016213923B9 (en) * 2009-04-22 2017-11-16 Medinol Ltd. Helical hybrid stent
US8795345B2 (en) * 2009-07-08 2014-08-05 Concentric Medical, Inc. Vascular and bodily duct treatment devices and methods
US8357179B2 (en) * 2009-07-08 2013-01-22 Concentric Medical, Inc. Vascular and bodily duct treatment devices and methods
US20110009941A1 (en) * 2009-07-08 2011-01-13 Concentric Medical, Inc. Vascular and bodily duct treatment devices and methods
US8795317B2 (en) * 2009-07-08 2014-08-05 Concentric Medical, Inc. Embolic obstruction retrieval devices and methods
US8529596B2 (en) 2009-07-08 2013-09-10 Concentric Medical, Inc. Vascular and bodily duct treatment devices and methods
US8357178B2 (en) * 2009-07-08 2013-01-22 Concentric Medical, Inc. Vascular and bodily duct treatment devices and methods
BR112013019925A2 (en) 2011-02-04 2016-12-13 Concentric Medical Inc devices and treatment methods body duct and vascular
DE102009041025A1 (en) * 2009-09-14 2011-03-24 Acandis Gmbh & Co. Kg medical implant
US8361140B2 (en) * 2009-12-29 2013-01-29 Boston Scientific Scimed, Inc. High strength low opening pressure stent design
US8888838B2 (en) * 2009-12-31 2014-11-18 W. L. Gore & Associates, Inc. Endoprosthesis containing multi-phase ferrous steel
US8808353B2 (en) 2010-01-30 2014-08-19 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds having a low crossing profile
US8568471B2 (en) 2010-01-30 2013-10-29 Abbott Cardiovascular Systems Inc. Crush recoverable polymer scaffolds
BR112013005277A2 (en) 2010-09-10 2016-05-17 Symetis Sa valve replacement devices, a delivery device for valve replacement device and a replacement valve device production method
EP2658484A1 (en) * 2010-12-30 2013-11-06 Boston Scientific Scimed, Inc. Multi stage opening stent designs
WO2012119037A1 (en) 2011-03-03 2012-09-07 Boston Scientific Scimed, Inc. Stent with reduced profile
WO2012118526A1 (en) 2011-03-03 2012-09-07 Boston Scientific Scimed, Inc. Low strain high strength stent
US9668859B2 (en) 2011-08-05 2017-06-06 California Institute Of Technology Percutaneous heart valve delivery systems
EP2967945A4 (en) 2013-03-15 2016-11-09 California Inst Of Techn Handle mechanism and functionality for repositioning and retrieval of transcatheter heart valves
US10154904B2 (en) 2014-04-28 2018-12-18 Edwards Lifesciences Corporation Intravascular introducer devices
US10195025B2 (en) 2014-05-12 2019-02-05 Edwards Lifesciences Corporation Prosthetic heart valve
US10201417B2 (en) 2015-02-03 2019-02-12 Boston Scientific Scimed Inc. Prosthetic heart valve having tubular seal
US9999527B2 (en) * 2015-02-11 2018-06-19 Abbott Cardiovascular Systems Inc. Scaffolds having radiopaque markers
US9974650B2 (en) 2015-07-14 2018-05-22 Edwards Lifesciences Corporation Prosthetic heart valve
US10179043B2 (en) 2016-02-12 2019-01-15 Edwards Lifesciences Corporation Prosthetic heart valve having multi-level sealing member
US10201416B2 (en) 2016-05-16 2019-02-12 Boston Scientific Scimed, Inc. Replacement heart valve implant with invertible leaflets

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5578071A (en) * 1990-06-11 1996-11-26 Parodi; Juan C. Aortic graft
US5507771A (en) * 1992-06-15 1996-04-16 Cook Incorporated Stent assembly
US5449373A (en) * 1994-03-17 1995-09-12 Medinol Ltd. Articulated stent
DE69527141T2 (en) * 1994-04-29 2002-11-07 Scimed Life Systems Inc Stent with collagen
US5397355A (en) * 1994-07-19 1995-03-14 Stentco, Inc. Intraluminal stent
AU3783195A (en) * 1994-11-15 1996-05-23 Advanced Cardiovascular Systems Inc. Intraluminal stent for attaching a graft
US5681345A (en) * 1995-03-01 1997-10-28 Scimed Life Systems, Inc. Sleeve carrying stent
US5556414A (en) * 1995-03-08 1996-09-17 Wayne State University Composite intraluminal graft
CA2171896C (en) * 1995-03-17 2007-05-15 Scott C. Anderson Multi-anchor stent
US5667523A (en) * 1995-04-28 1997-09-16 Impra, Inc. Dual supported intraluminal graft
US5824037A (en) * 1995-10-03 1998-10-20 Medtronic, Inc. Modular intraluminal prostheses construction and methods
US5695516A (en) * 1996-02-21 1997-12-09 Iso Stent, Inc. Longitudinally elongating balloon expandable stent
US5697971A (en) * 1996-06-11 1997-12-16 Fischell; Robert E. Multi-cell stent with cells having differing characteristics
US5807404A (en) * 1996-09-19 1998-09-15 Medinol Ltd. Stent with variable features to optimize support and method of making such stent
DE19717475C1 (en) * 1997-04-25 1998-09-03 Heraeus Gmbh W C Radially expandable support structure or stent for tubular vessel in body

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100318181A1 (en) * 1998-12-11 2010-12-16 Endologix, Inc. Implantable vascular graft
US20040093072A1 (en) * 2002-05-06 2004-05-13 Jeff Pappas Endoprosthesis for controlled contraction and expansion
US20100063581A1 (en) * 2002-05-06 2010-03-11 Jeff Pappas Endoprosthesis For Controlled Contraction And Expansion
US7637935B2 (en) 2002-05-06 2009-12-29 Abbott Laboratories Endoprosthesis for controlled contraction and expansion
US8075610B2 (en) 2002-05-06 2011-12-13 Abbott Laboratories Endoprosthesis for controlled contraction and expansion
US7559947B2 (en) 2002-05-08 2009-07-14 Abbott Laboratories Endoprosthesis having foot extensions
US20040093073A1 (en) * 2002-05-08 2004-05-13 David Lowe Endoprosthesis having foot extensions
US20060142844A1 (en) * 2002-05-08 2006-06-29 David Lowe Endoprosthesis having foot extensions
US7128756B2 (en) 2002-05-08 2006-10-31 Abbott Laboratories Endoprosthesis having foot extensions
US7985249B2 (en) 2002-05-08 2011-07-26 Abbott Laboratories Corporation Endoprosthesis having foot extensions
KR101055157B1 (en) * 2003-02-25 2011-08-08 코디스 코포레이션 Having a superposition type finger for reinforcing the blood vessel stent protection
US7625398B2 (en) 2003-05-06 2009-12-01 Abbott Laboratories Endoprosthesis having foot extensions
US20070021834A1 (en) * 2003-05-06 2007-01-25 Eugene Young Endoprosthesis having foot extensions
US20060015173A1 (en) * 2003-05-06 2006-01-19 Anton Clifford Endoprosthesis having foot extensions
US8109991B2 (en) 2003-05-06 2012-02-07 Abbot Laboratories Endoprosthesis having foot extensions
US8915954B2 (en) 2003-05-06 2014-12-23 Abbott Laboratories Endoprosthesis having foot extensions
US20050107865A1 (en) * 2003-05-06 2005-05-19 Anton Clifford Endoprosthesis having foot extensions
US8048146B2 (en) 2003-05-06 2011-11-01 Abbott Laboratories Endoprosthesis having foot extensions
US7625401B2 (en) 2003-05-06 2009-12-01 Abbott Laboratories Endoprosthesis having foot extensions
US20070043432A1 (en) * 2004-02-11 2007-02-22 Eric Perouse Tubular prosthesis
WO2005079705A1 (en) * 2004-02-11 2005-09-01 Laboratoires Perouse Tubular prosthesis
US8361137B2 (en) 2004-02-11 2013-01-29 Laboratories Perouse Tubular prosthesis
FR2865926A1 (en) * 2004-02-11 2005-08-12 Perouse Laboratoires Tubular prosthesis e.g. stent, for treating blood vessel e.g. vein, has three clamps regularly and angularly distributed at its periphery, where each clamp has two hooks movable between deployed and closure positions
WO2015114463A3 (en) * 2014-02-02 2016-03-03 Gil Hefer Apparatus and methods for recannalization, valve repair and replacement
US9724121B2 (en) 2014-02-02 2017-08-08 TriReme Medical, LLC Apparatus and methods for recannalization, valve repair and replacement

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WO1998026732A1 (en) 1998-06-25

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