UA97957C2 - 2-{5-fluoro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1h-indol-1-yl}acetic acid and derivatives thereof, use thereof for the treatment of diseases mediated by pgd2 action at the crth2 receptor - Google Patents

2-{5-fluoro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1h-indol-1-yl}acetic acid and derivatives thereof, use thereof for the treatment of diseases mediated by pgd2 action at the crth2 receptor

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Publication number
UA97957C2
UA97957C2 UAA200900835A UAA200900835A UA97957C2 UA 97957 C2 UA97957 C2 UA 97957C2 UA A200900835 A UAA200900835 A UA A200900835A UA A200900835 A UAA200900835 A UA A200900835A UA 97957 C2 UA97957 C2 UA 97957C2
Authority
UA
Ukraine
Prior art keywords
treatment
pgd2
phenylsulfonyl
indol
fluoro
Prior art date
Application number
UAA200900835A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Ричард Эдвард Армер
Грахам Михаэль Вайн
Original Assignee
Оксаджен Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оксаджен Лимитед filed Critical Оксаджен Лимитед
Priority claimed from PCT/GB2007/002761 external-priority patent/WO2008012511A1/en
Publication of UA97957C2 publication Critical patent/UA97957C2/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of general formula (I) wherein R is phenyl optionally substituted with one or more halo substituents; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis., (I)
UAA200900835A 2006-07-22 2007-07-20 2-{5-fluoro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1h-indol-1-yl}acetic acid and derivatives thereof, use thereof for the treatment of diseases mediated by pgd2 action at the crth2 receptor UA97957C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0614608A GB0614608D0 (en) 2006-07-22 2006-07-22 Compounds having CRTH2 antagonist activity
PCT/GB2007/002761 WO2008012511A1 (en) 2006-07-22 2007-07-20 Compounds having crth2 antagonist activity

Publications (1)

Publication Number Publication Date
UA97957C2 true UA97957C2 (en) 2012-04-10

Family

ID=36998568

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200900835A UA97957C2 (en) 2006-07-22 2007-07-20 2-{5-fluoro-2-methyl-3-[2-(phenylsulfonyl)benzyl]-1h-indol-1-yl}acetic acid and derivatives thereof, use thereof for the treatment of diseases mediated by pgd2 action at the crth2 receptor

Country Status (4)

Country Link
CN (1) CN101506159B (en)
GB (1) GB0614608D0 (en)
UA (1) UA97957C2 (en)
ZA (1) ZA200900393B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111458507B (en) * 2020-04-14 2023-09-12 中国人民解放军海军军医大学第三附属医院 Marker for evaluating sensitivity of intrahepatic bile duct cancer gemcitabine chemotherapy and application thereof
CN113684238A (en) * 2021-08-09 2021-11-23 广州医科大学附属第一医院（广州呼吸中心） Use of CXC chemokine receptor 3 as cough drug target
CN114478350B (en) * 2022-01-25 2023-08-11 苏州大学 Preparation method of C3-alkylated indole
CN114609272B (en) * 2022-02-22 2023-08-11 植恩生物技术股份有限公司 Method for detecting mesilate impurity JH-ZZD

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641800A (en) * 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
US7534897B2 (en) * 2002-05-16 2009-05-19 Shionogi & Co., Ltd. Indole arylsulfonaimide compounds exhibiting PGD 2 receptor antagonism

Also Published As

Publication number Publication date
CN101506159B (en) 2012-08-22
ZA200900393B (en) 2010-03-31
CN101506159A (en) 2009-08-12
GB0614608D0 (en) 2006-08-30

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