UA95239C2 - Macrocyclic inhibitors of hepatitis c virus - Google Patents

Macrocyclic inhibitors of hepatitis c virus

Info

Publication number
UA95239C2
UA95239C2 UAA200714714A UAA200714714A UA95239C2 UA 95239 C2 UA95239 C2 UA 95239C2 UA A200714714 A UAA200714714 A UA A200714714A UA A200714714 A UAA200714714 A UA A200714714A UA 95239 C2 UA95239 C2 UA 95239C2
Authority
UA
Ukraine
Prior art keywords
inhibitors
hepatitis
virus
hcv
formula
Prior art date
Application number
UAA200714714A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Кок Герман Августинус Де
Пьер Жан-Мари Бернар Рабуассон
Кеннет Алан Симмен
Матс Стефан Линдстром
Пиа Сесилия Канберг
Дмитрий Антонов
Карл Магнус Нилссон
Бенгт Бертил Самуэльссон
Эса Анника Кристина Розенквист
Original Assignee
Тиботек Фармасьютикелз Лтд.
Медивир Аб
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тиботек Фармасьютикелз Лтд., Медивир Аб filed Critical Тиботек Фармасьютикелз Лтд.
Publication of UA95239C2 publication Critical patent/UA95239C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Abstract

Inhibitors of HCV of formula (I), and the W-oxides, salts, and stereoisomers thereof, wherein the dashed line represents an optional double bond between atoms C7 and C8; Ris hydrogen or Calkyl; R is hydrogen or C; and n is 3,4,5, or 6; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I) are provided. Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
UAA200714714A 2005-07-29 2006-07-28 Macrocyclic inhibitors of hepatitis c virus UA95239C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107066 2005-07-29

Publications (1)

Publication Number Publication Date
UA95239C2 true UA95239C2 (en) 2011-07-25

Family

ID=35601774

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200714714A UA95239C2 (en) 2005-07-29 2006-07-28 Macrocyclic inhibitors of hepatitis c virus

Country Status (4)

Country Link
AP (1) AP2387A (en)
ES (1) ES2360417T3 (en)
UA (1) UA95239C2 (en)
ZA (1) ZA200800856B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA74546C2 (en) * 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
PT1713823E (en) * 2004-01-30 2010-02-02 Medivir Ab Hcv ns-3 serine protease inhibitors

Also Published As

Publication number Publication date
ZA200800856B (en) 2009-06-24
ES2360417T3 (en) 2011-06-03
AP2387A (en) 2012-03-26

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