UA79674C2 - Triazol compounds suitable for use in therapeutics - Google Patents

Info

Publication number

UA79674C2

UA79674C2 UAA200508142A UA2005008142A UA79674C2 UA 79674 C2 UA79674 C2 UA 79674C2 UA A200508142 A UAA200508142 A UA A200508142A UA 2005008142 A UA2005008142 A UA 2005008142A UA 79674 C2 UA79674 C2 UA 79674C2

Authority

UA

Ukraine

Prior art keywords

compound

chloro

tetrahydro

formula

dichloromethane

Prior art date

2003-07-23

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 title description 9
• QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical class C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 420
• 206010013935 Dysmenorrhoea Diseases 0.000 claims abstract description 41
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 36
• 229910052736 halogen Inorganic materials 0.000 claims abstract description 31
• 150000002367 halogens Chemical class 0.000 claims abstract description 29
• 125000004429 atom Chemical group 0.000 claims abstract description 20
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 17
• 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 14
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 13
• 229920006395 saturated elastomer Polymers 0.000 claims abstract description 13
• 229910052799 carbon Inorganic materials 0.000 claims abstract description 12
• 125000003545 alkoxy group Chemical group 0.000 claims abstract description 10
• 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 7
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 7
• 125000005842 heteroatom Chemical group 0.000 claims abstract description 3
• CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 claims description 107
• 238000000034 method Methods 0.000 claims description 99
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 36
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• 208000035475 disorder Diseases 0.000 claims description 18
• 238000002360 preparation method Methods 0.000 claims description 18
• 125000003632 azulen-5-yl group Chemical group [H]C1=C([H])C2=C([H])C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims description 17
• 230000002028 premature Effects 0.000 claims description 17
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
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• QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 claims description 6
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• 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
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• 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
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• CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 102
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• 238000010898 silica gel chromatography Methods 0.000 description 40
• WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 description 38
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