UA78578C2 - Bicyclic heteroaromatic derivatives as inhibitors of p38 kinase - Google Patents

Info

Publication number

UA78578C2

UA78578C2 UAA200500509A UA2005000509A UA78578C2 UA 78578 C2 UA78578 C2 UA 78578C2 UA A200500509 A UAA200500509 A UA A200500509A UA 2005000509 A UA2005000509 A UA 2005000509A UA 78578 C2 UA78578 C2 UA 78578C2

Authority

UA

Ukraine

Prior art keywords

group

oxo

hplc

minutes

optionally substituted

Prior art date

2002-06-20

Links

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• 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 title abstract description 12
• 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title abstract description 12
• 239000003112 inhibitor Substances 0.000 title description 22
• 150000001875 compounds Chemical class 0.000 claims abstract description 424
• 125000004429 atom Chemical group 0.000 claims abstract description 55
• 125000003118 aryl group Chemical group 0.000 claims abstract description 35
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 19
• 125000001931 aliphatic group Chemical group 0.000 claims abstract description 15
• 229910052799 carbon Inorganic materials 0.000 claims abstract description 15
• 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 12
• 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 6
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 141
• 125000001072 heteroaryl group Chemical group 0.000 claims description 44
• 125000000217 alkyl group Chemical group 0.000 claims description 43
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 41
• 125000005843 halogen group Chemical group 0.000 claims description 20
• 125000004076 pyridyl group Chemical group 0.000 claims description 17
• 150000003839 salts Chemical class 0.000 claims description 17
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 15
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 12
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 11
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 8
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
• 125000001544 thienyl group Chemical group 0.000 claims description 8
• 125000002541 furyl group Chemical group 0.000 claims description 7
• 125000002950 monocyclic group Chemical group 0.000 claims description 7
• 125000000168 pyrrolyl group Chemical group 0.000 claims description 7
• 150000003573 thiols Chemical class 0.000 claims description 7
• 239000003085 diluting agent Substances 0.000 claims description 6
• 125000000335 thiazolyl group Chemical group 0.000 claims description 6
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 5
• 125000002971 oxazolyl group Chemical group 0.000 claims description 5
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• 125000004306 triazinyl group Chemical group 0.000 claims description 5
• 239000003937 drug carrier Substances 0.000 claims description 4
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 4
• 150000004677 hydrates Chemical class 0.000 claims description 4
• 125000001041 indolyl group Chemical group 0.000 claims description 4
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
• 239000012453 solvate Substances 0.000 claims description 4
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• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 10
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• 125000005842 heteroatom Chemical group 0.000 description 21
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