UA49827C2 - СПОСІБ ДІАГНОСТИКИ ШИЗОФРЕНІЇ, ПАРА ПРАЙМЕРІВ ДЛЯ ВИКОРИСТАННЯ В СПОСОБІ, НАБІР ДЛЯ ВИЗНАЧЕННЯ АЛЕЛІ E<font face="Symbol">r</font> МІКРОСАТЕЛІТА HUMTH01 - Google Patents

СПОСІБ ДІАГНОСТИКИ ШИЗОФРЕНІЇ, ПАРА ПРАЙМЕРІВ ДЛЯ ВИКОРИСТАННЯ В СПОСОБІ, НАБІР ДЛЯ ВИЗНАЧЕННЯ АЛЕЛІ E<font face="Symbol">r</font> МІКРОСАТЕЛІТА HUMTH01

Info

Publication number
UA49827C2
UA49827C2 UA97105318A UA97105318A UA49827C2 UA 49827 C2 UA49827 C2 UA 49827C2 UA 97105318 A UA97105318 A UA 97105318A UA 97105318 A UA97105318 A UA 97105318A UA 49827 C2 UA49827 C2 UA 49827C2
Authority
UA
Ukraine
Prior art keywords
schizophrenia
diagnostics
primer pair
determining allele
humth01
Prior art date
Application number
UA97105318A
Other languages
English (en)
Russian (ru)
Inventor
Клодін Лоран
Жак Малє
Роландо Мелоні
Original Assignee
Рон-Пуленк Рорер С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рон-Пуленк Рорер С.А. filed Critical Рон-Пуленк Рорер С.А.
Publication of UA49827C2 publication Critical patent/UA49827C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Даний винахід належить до методу діагностики шизофренії, який базується на визначенні in vitro наявності алелі Ер мікросателіта HUMTH01 в гені TH. Винахід також належить до праймерів, які використовуються для здійснення цього методу.
UA97105318A 1995-05-03 1996-04-29 СПОСІБ ДІАГНОСТИКИ ШИЗОФРЕНІЇ, ПАРА ПРАЙМЕРІВ ДЛЯ ВИКОРИСТАННЯ В СПОСОБІ, НАБІР ДЛЯ ВИЗНАЧЕННЯ АЛЕЛІ E<font face="Symbol">r</font> МІКРОСАТЕЛІТА HUMTH01 UA49827C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9505264A FR2733766B1 (fr) 1995-05-03 1995-05-03 Methode de diagnostic de la schizophrenie
PCT/FR1996/000650 WO1996034980A1 (fr) 1995-05-03 1996-04-29 Methode de diagnostic de la schizophrenie

Publications (1)

Publication Number Publication Date
UA49827C2 true UA49827C2 (uk) 2002-10-15

Family

ID=9478648

Family Applications (1)

Application Number Title Priority Date Filing Date
UA97105318A UA49827C2 (uk) 1995-05-03 1996-04-29 СПОСІБ ДІАГНОСТИКИ ШИЗОФРЕНІЇ, ПАРА ПРАЙМЕРІВ ДЛЯ ВИКОРИСТАННЯ В СПОСОБІ, НАБІР ДЛЯ ВИЗНАЧЕННЯ АЛЕЛІ E<font face="Symbol">r</font> МІКРОСАТЕЛІТА HUMTH01

Country Status (29)

Country Link
US (1) US6210879B1 (uk)
EP (1) EP0826068B1 (uk)
JP (1) JPH11504809A (uk)
KR (1) KR19990008221A (uk)
CN (1) CN1125881C (uk)
AP (1) AP770A (uk)
AT (1) ATE193559T1 (uk)
AU (1) AU715264B2 (uk)
BG (1) BG63017B1 (uk)
BR (1) BR9608432A (uk)
CA (1) CA2217332A1 (uk)
CZ (1) CZ291234B6 (uk)
DE (1) DE69608682T2 (uk)
DK (1) DK0826068T3 (uk)
EA (1) EA001037B1 (uk)
ES (1) ES2148760T3 (uk)
FR (1) FR2733766B1 (uk)
GR (1) GR3033592T3 (uk)
HU (1) HUP9802918A3 (uk)
NO (1) NO974974L (uk)
NZ (1) NZ308132A (uk)
OA (1) OA10534A (uk)
PL (1) PL183819B1 (uk)
PT (1) PT826068E (uk)
RO (1) RO116731B1 (uk)
SI (1) SI0826068T1 (uk)
SK (1) SK282119B6 (uk)
UA (1) UA49827C2 (uk)
WO (1) WO1996034980A1 (uk)

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* Cited by examiner, † Cited by third party
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US6566065B1 (en) * 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
US6395524B2 (en) 1996-11-27 2002-05-28 University Of Washington Thermostable polymerases having altered fidelity and method of identifying and using same
US7166462B2 (en) 2000-08-24 2007-01-23 Vanderbult University Methods and systems for facilitating the diagnosis and treatment of schizophrenia
AU2001286888A1 (en) * 2000-08-30 2002-03-13 Lorraine Iacovitti Tyrosine hydroxylase 5' control elements and uses thereof
US20070072233A1 (en) * 2001-05-01 2007-03-29 Levitt Pat R Methods and systems for facilitating the diagnosis and treatment of schizophrenia
DE10141464A1 (de) * 2001-08-23 2004-03-04 Genprofile Ag I.Ins. Sequenzvarianten des für neuropsychiatrische Krankheiten verantwortlichen Gens 22444 und deren Verwendung
US6764824B2 (en) * 2002-03-21 2004-07-20 Council Of Scientific And Industrial Research Primers for screening schizophrenia and a method thereof
AU2003231562A1 (en) * 2003-05-19 2004-12-03 Institute Of Mental Health, Peking University Detecting method of the schizophrenia susceptible gene and use
US9399215B2 (en) 2012-04-13 2016-07-26 Bio-Rad Laboratories, Inc. Sample holder with a well having a wicking promoter
US9492797B2 (en) 2008-09-23 2016-11-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US8663920B2 (en) 2011-07-29 2014-03-04 Bio-Rad Laboratories, Inc. Library characterization by digital assay
US9132394B2 (en) 2008-09-23 2015-09-15 Bio-Rad Laboratories, Inc. System for detection of spaced droplets
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
US9764322B2 (en) 2008-09-23 2017-09-19 Bio-Rad Laboratories, Inc. System for generating droplets with pressure monitoring
US8633015B2 (en) * 2008-09-23 2014-01-21 Bio-Rad Laboratories, Inc. Flow-based thermocycling system with thermoelectric cooler
US11130128B2 (en) 2008-09-23 2021-09-28 Bio-Rad Laboratories, Inc. Detection method for a target nucleic acid
US10512910B2 (en) 2008-09-23 2019-12-24 Bio-Rad Laboratories, Inc. Droplet-based analysis method
US8951939B2 (en) 2011-07-12 2015-02-10 Bio-Rad Laboratories, Inc. Digital assays with multiplexed detection of two or more targets in the same optical channel
US9417190B2 (en) 2008-09-23 2016-08-16 Bio-Rad Laboratories, Inc. Calibrations and controls for droplet-based assays
US8709762B2 (en) 2010-03-02 2014-04-29 Bio-Rad Laboratories, Inc. System for hot-start amplification via a multiple emulsion
CA3021714C (en) 2009-09-02 2021-03-09 Bio-Rad Laboratories, Inc. System for mixing fluids by coalescence of multiple emulsions
US8399198B2 (en) 2010-03-02 2013-03-19 Bio-Rad Laboratories, Inc. Assays with droplets transformed into capsules
CA2767113A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Detection system for droplet-based assays
JP2013524171A (ja) 2010-03-25 2013-06-17 クァンタライフ・インコーポレーテッド 液滴ベースのアッセイのための液滴の発生
CA2767114A1 (en) 2010-03-25 2011-09-29 Bio-Rad Laboratories, Inc. Droplet transport system for detection
CA2816712C (en) 2010-11-01 2018-12-11 Donald A. Masquelier System for forming emulsions
AU2012231098B2 (en) 2011-03-18 2016-09-29 Bio-Rad Laboratories, Inc. Multiplexed digital assays with combinatorial use of signals
CN103717749A (zh) 2011-04-25 2014-04-09 伯乐生命医学产品有限公司 用于核酸分析的方法和组合物
CN107677831A (zh) * 2017-06-28 2018-02-09 深圳市龙岗中心医院 测定用于评估精神分裂症病人的诊断标志物的方法

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US5861504A (en) * 1991-05-29 1999-01-19 The United States Of America As Represented By The Department Of Health And Human Services Eleven highly informative microsatelite repeat polymorphic DNA markers

Also Published As

Publication number Publication date
FR2733766A1 (fr) 1996-11-08
KR19990008221A (ko) 1999-01-25
CN1125881C (zh) 2003-10-29
AU715264B2 (en) 2000-01-20
DE69608682T2 (de) 2000-10-26
SI0826068T1 (en) 2000-10-31
RO116731B1 (ro) 2001-05-30
CZ346797A3 (cs) 1998-01-14
US6210879B1 (en) 2001-04-03
PT826068E (pt) 2000-12-29
JPH11504809A (ja) 1999-05-11
SK147997A3 (en) 1998-05-06
BG102016A (en) 1998-11-30
AP9701126A0 (en) 1997-10-31
DK0826068T3 (da) 2000-08-28
SK282119B6 (sk) 2001-11-06
OA10534A (fr) 2002-04-29
HUP9802918A3 (en) 2001-01-29
HUP9802918A2 (hu) 1999-03-29
BR9608432A (pt) 1999-03-02
EP0826068B1 (fr) 2000-05-31
NO974974D0 (no) 1997-10-28
WO1996034980A1 (fr) 1996-11-07
ES2148760T3 (es) 2000-10-16
AU5767896A (en) 1996-11-21
NZ308132A (en) 1999-10-28
ATE193559T1 (de) 2000-06-15
EA199700355A1 (ru) 1998-08-27
BG63017B1 (bg) 2001-01-31
CN1183122A (zh) 1998-05-27
DE69608682D1 (de) 2000-07-06
PL323178A1 (en) 1998-03-16
CZ291234B6 (cs) 2003-01-15
NO974974L (no) 1997-10-28
PL183819B1 (pl) 2002-07-31
AP770A (en) 1999-10-06
GR3033592T3 (en) 2000-09-29
CA2217332A1 (fr) 1996-11-07
FR2733766B1 (fr) 1997-06-06
EP0826068A1 (fr) 1998-03-04
EA001037B1 (ru) 2000-08-28

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