UA102693C2 - Производные фенилимидазола как ингибиторы фермента pde10a - Google Patents

Производные фенилимидазола как ингибиторы фермента pde10a

Info

Publication number
UA102693C2
UA102693C2 UAA201015420A UAA201015420A UA102693C2 UA 102693 C2 UA102693 C2 UA 102693C2 UA A201015420 A UAA201015420 A UA A201015420A UA A201015420 A UAA201015420 A UA A201015420A UA 102693 C2 UA102693 C2 UA 102693C2
Authority
UA
Ukraine
Prior art keywords
subject
compound
formula
effective amount
therapeutically effective
Prior art date
Application number
UAA201015420A
Other languages
English (en)
Russian (ru)
Ukrainian (uk)
Inventor
Андреас Ритсен
Ян Кехлер
Мортен Ланггор
Якоб Нильсен
Джон Пол Килберн
Мохамед Эм. Фарах
Original Assignee
Х. Луннбек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Луннбек А/С filed Critical Х. Луннбек А/С
Priority claimed from PCT/DK2009/050134 external-priority patent/WO2009152825A1/en
Publication of UA102693C2 publication Critical patent/UA102693C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
UAA201015420A 2008-06-20 2009-06-19 Производные фенилимидазола как ингибиторы фермента pde10a UA102693C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200800855 2008-06-20
PCT/DK2009/050134 WO2009152825A1 (en) 2008-06-20 2009-06-19 Novel phenylimidazole derivatives as pde10a enzyme inhibitors

Publications (1)

Publication Number Publication Date
UA102693C2 true UA102693C2 (ru) 2013-08-12

Family

ID=42321053

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201015420A UA102693C2 (ru) 2008-06-20 2009-06-19 Производные фенилимидазола как ингибиторы фермента pde10a
UAA201200499A UA106378C2 (ru) 2009-06-19 2010-06-17 Производные фенилимидазола как ингибиторы фермента pde10a

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201200499A UA106378C2 (ru) 2009-06-19 2010-06-17 Производные фенилимидазола как ингибиторы фермента pde10a

Country Status (27)

Country Link
EP (1) EP2443105B1 (el)
JP (1) JP5768044B2 (el)
AR (1) AR077144A1 (el)
AU (1) AU2010262190B2 (el)
CA (1) CA2765750A1 (el)
CR (1) CR20110654A (el)
CY (1) CY1115971T1 (el)
DK (1) DK2443105T3 (el)
DO (1) DOP2011000397A (el)
ES (1) ES2527216T3 (el)
GE (1) GEP20146100B (el)
GT (1) GT201100322A (el)
HR (1) HRP20141222T1 (el)
IL (1) IL216684A (el)
MA (1) MA33367B1 (el)
MX (1) MX2011013400A (el)
MY (1) MY156785A (el)
NZ (1) NZ597203A (el)
PL (1) PL2443105T3 (el)
PT (1) PT2443105E (el)
SG (1) SG176680A1 (el)
SI (1) SI2443105T1 (el)
SM (1) SMT201500003B (el)
TW (1) TW201100430A (el)
UA (2) UA102693C2 (el)
WO (1) WO2010145668A1 (el)
ZA (1) ZA201109271B (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8133897B2 (en) 2008-06-20 2012-03-13 H. Lundbeck A/S Phenylimidazole derivatives as PDE10A enzyme inhibitors
TWI501965B (zh) 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物
TWI485151B (zh) 2009-12-17 2015-05-21 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物
US8552045B2 (en) 2010-11-19 2013-10-08 H. Lundbeck A/S Tricyclic imidazole compounds as PDE10 inhibitors
JO3089B1 (ar) * 2010-11-19 2017-03-15 H Lundbeck As مشتقات ايميدازول كمثبطات لانزيمات pde10a
WO2012112946A1 (en) 2011-02-18 2012-08-23 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (pde10a)
CN103874701A (zh) * 2011-09-09 2014-06-18 H.隆德贝克有限公司 吡啶化合物和其用途
WO2013034761A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Pyridine compounds and uses thereof
WO2013034755A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Triazolopyrazine derivatives and their use for treating neurological and psychiatric disorders
WO2013034758A1 (en) * 2011-09-09 2013-03-14 H. Lundbeck A/S Substituted triazolopyrazines and uses thereof
TWI570124B (zh) 2011-12-21 2017-02-11 Ｈ 朗德貝克公司 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物
WO2013107856A1 (en) * 2012-01-20 2013-07-25 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2013127817A1 (en) 2012-02-27 2013-09-06 H. Lundbeck A/S Imidazole derivatives as pde10a enzyme inhibitors
WO2014071044A1 (en) 2012-11-01 2014-05-08 Allergan, Inc. Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a)
US9200016B2 (en) 2013-12-05 2015-12-01 Allergan, Inc. Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A)
WO2020094592A1 (en) * 2018-11-06 2020-05-14 H. Lundbeck A/S Compounds for treating negative symptoms and cognitive impairments
BR112020013743A2 (pt) * 2018-11-06 2020-12-01 H. Lundbeck A/S hemiadipato de 5,8-dimetil-2-[2-(1-metil-4-fenil-1h-imidazol-2-il)-etil]-[1,2,4]triazolo[1,5-a]pirazina

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4826833A (en) 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US20030032579A1 (en) 2001-04-20 2003-02-13 Pfizer Inc. Therapeutic use of selective PDE10 inhibitors
IL149106A0 (en) 2001-04-20 2002-11-10 Pfizer Prod Inc Therapeutic use of selective pde10 inhibitors
FR2824065A1 (fr) 2001-04-26 2002-10-31 Neuro3D Composes inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations
US7368578B2 (en) 2002-09-10 2008-05-06 Takeda Pharmaceutical Company Limited Five-membered heterocyclic compounds
EP1556055B1 (fr) 2002-10-30 2008-10-29 Via Pharmaceuticals, Inc. Inhibiteurs des phosphodiesterases des nucleotides cycliques, ayant une structure benzodiazepinique, et leur utilisation en therapie
WO2005002579A1 (en) 2003-06-30 2005-01-13 Altana Pharma Ag Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors
DE602004028827D1 (de) 2003-06-30 2010-10-07 Nycomed Gmbh Pyrrolodihydroisochinoline als pde10- inhibitoren
WO2005012485A2 (en) 2003-07-31 2005-02-10 Bayer Pharmaceuticals Corporation Methods for treating diabetes and related disorders using pde10a inhibitors
EP1723134A2 (en) 2004-02-18 2006-11-22 Pfizer Products Incorporated Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
FR2870539B1 (fr) 2004-05-19 2006-08-04 Greenpharma Sa Sa Nouvelles methodes et medicaments
WO2005120514A1 (en) 2004-06-07 2005-12-22 Pfizer Products Inc. Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions
US20060019975A1 (en) 2004-07-23 2006-01-26 Pfizer Inc Novel piperidyl derivatives of quinazoline and isoquinoline
AU2005282721A1 (en) 2004-09-03 2006-03-16 Memory Pharmaceuticals Corporation 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms
US20060183763A1 (en) * 2004-12-31 2006-08-17 Pfizer Inc Novel pyrrolidyl derivatives of heteroaromatic compounds
EP1991530A1 (en) * 2006-02-21 2008-11-19 Amgen Inc. Cinnoline derivatives as phosphodiesterase 10 inhibitors
TWI501965B (zh) * 2008-06-20 2015-10-01 Lundbeck & Co As H 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物

Also Published As

Publication number Publication date
TW201100430A (en) 2011-01-01
SMT201500003B (it) 2015-03-05
SI2443105T1 (sl) 2015-02-27
HRP20141222T1 (hr) 2015-02-27
ZA201109271B (en) 2013-02-27
CY1115971T1 (el) 2017-01-25
CA2765750A1 (en) 2010-12-23
MA33367B1 (fr) 2012-06-01
JP5768044B2 (ja) 2015-08-26
NZ597203A (en) 2013-03-28
SG176680A1 (en) 2012-01-30
DK2443105T3 (en) 2015-01-12
AU2010262190A1 (en) 2012-01-19
MY156785A (en) 2016-03-31
MX2011013400A (es) 2012-02-21
PT2443105E (pt) 2015-01-14
GT201100322A (es) 2014-02-06
WO2010145668A1 (en) 2010-12-23
GEP20146100B (en) 2014-05-27
EP2443105B1 (en) 2014-10-29
IL216684A (en) 2016-03-31
PL2443105T3 (pl) 2015-03-31
DOP2011000397A (es) 2012-07-15
EP2443105A1 (en) 2012-04-25
CR20110654A (es) 2012-03-09
AU2010262190B2 (en) 2013-01-31
IL216684A0 (en) 2012-02-29
UA106378C2 (ru) 2014-08-26
JP2012530086A (ja) 2012-11-29
ES2527216T3 (es) 2015-01-21
AR077144A1 (es) 2011-08-03

Similar Documents

Publication Publication Date Title
MY152949A (en) Novel phenylimidazole derivatives as pde10a enzyme inhibitors
UA102693C2 (ru) Производные фенилимидазола как ингибиторы фермента pde10a
TN2012000287A1 (en) 2-arylimidazole derivatives as pde10a enzyme inhibitors
TN2012000271A1 (en) Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors
TN2012000278A1 (en) Heteroaromatic aryl triazole derivatives as pde10a enzyme inhibitors
IN2015DN02829A (el)
JO3089B1 (ar) مشتقات ايميدازول كمثبطات لانزيمات pde10a
PH12014501695B1 (en) Pde9 inhibitors with imidazo triazinone backbone
MX336915B (es) Derivados de imidazol como inhibidores de la enzima pde10a.
TN2013000200A1 (en) Imidazole derivatives as pde 10a enzyme inhibitors
CY1116689T1 (el) Παραγωγα ιμιδαζολης ως αναστολεις του ενζυμου pde10a
TN2014000288A1 (en) Pde9 inhibitors with imidazo triazinone backbone