TWI889816B - 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 - Google Patents

用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法

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Publication number
TWI889816B
TWI889816B TW110116253A TW110116253A TWI889816B TW I889816 B TWI889816 B TW I889816B TW 110116253 A TW110116253 A TW 110116253A TW 110116253 A TW110116253 A TW 110116253A TW I889816 B TWI889816 B TW I889816B
Authority
TW
Taiwan
Prior art keywords
conductive
gel
layer
conductive gel
pad
Prior art date
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TW110116253A
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English (en)
Chinese (zh)
Other versions
TW202200232A (zh
Inventor
理查德 德斯勞里斯
Original Assignee
瑞士商諾沃庫勒有限責任公司
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Publication of TW202200232A publication Critical patent/TW202200232A/zh
Application granted granted Critical
Publication of TWI889816B publication Critical patent/TWI889816B/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0492Patch electrodes
    • A61N1/0496Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0484Garment electrodes worn by the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0472Structure-related aspects
    • A61N1/0492Patch electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/06Electrodes for high-frequency therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002Cancer treatment, e.g. tumour
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/3603Control systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014External stimulators, e.g. with patch electrodes
    • A61N1/3603Control systems
    • A61N1/36034Control systems specified by the stimulation parameters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/40Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW110116253A 2020-05-06 2021-05-05 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法 TWI889816B (zh)

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US202063020636P 2020-05-06 2020-05-06
US63/020,636 2020-05-06
US202063030138P 2020-05-26 2020-05-26
US63/030,138 2020-05-26
US202063046364P 2020-06-30 2020-06-30
US63/046,364 2020-06-30
US202063061419P 2020-08-05 2020-08-05
US202063061316P 2020-08-05 2020-08-05
US63/061,316 2020-08-05
US63/061,419 2020-08-05
US202063068213P 2020-08-20 2020-08-20
US63/068,213 2020-08-20
US202063085476P 2020-09-30 2020-09-30
US63/085,476 2020-09-30
US202063128276P 2020-12-21 2020-12-21
US63/128,276 2020-12-21
US202163141315P 2021-01-25 2021-01-25
US63/141,315 2021-01-25

Publications (2)

Publication Number Publication Date
TW202200232A TW202200232A (zh) 2022-01-01
TWI889816B true TWI889816B (zh) 2025-07-11

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
TW110116253A TWI889816B (zh) 2020-05-06 2021-05-05 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法
TW114122484A TW202537657A (zh) 2020-05-06 2021-05-05 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法

Family Applications After (1)

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TW114122484A TW202537657A (zh) 2020-05-06 2021-05-05 用於產生腫瘤治療電場之導電襯墊以及生產和使用其之方法

Country Status (6)

Country Link
US (9) US20210346693A1 (https=)
EP (1) EP4146326A1 (https=)
JP (1) JP2023524532A (https=)
CN (1) CN116367881A (https=)
TW (2) TWI889816B (https=)
WO (1) WO2021226353A1 (https=)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180001075A1 (en) * 2016-06-30 2018-01-04 Novocure Limited Arrays for Longitudinal Delivery of TTFields to a Body
WO2022003419A1 (en) * 2020-06-30 2022-01-06 Novocure Gmbh Flexible transducer arrays with a polymer insulating layer for applying tumor treating fields (ttfields)
US20240269473A1 (en) * 2021-06-25 2024-08-15 Northwestern University Bioresorbable cardiovascular instruments, and operation and fabrication methods of same
WO2023275749A1 (en) * 2021-06-30 2023-01-05 Novocure Gmbh Using capacitors to regulate current in transducer arrays for applying tumor treating fields (ttfields)
IT202100022166A1 (it) * 2021-08-23 2023-02-23 Led S P A Elettrodo neutro flessibile per la radiofrequenza chirurgica e fisioterapica e kit associato
WO2023042080A1 (en) 2021-09-14 2023-03-23 Novocure Gmbh Temperature independent method and system for applying ttfields
US12527954B2 (en) 2021-09-30 2026-01-20 Novocure Gmbh Method and system for applying tumor treating fields interfacing with hair follicles
CN114162821B (zh) * 2021-12-08 2023-04-25 中国地质大学(北京) 肖特基结复合材料及其制备方法和应用
US12434051B2 (en) 2021-12-10 2025-10-07 Novocure Gmbh Compression garment assembly for applying TTFields and methods of production and use thereof
EP4649993A3 (en) 2021-12-10 2025-12-31 Novocure GmbH COMPRESSION GARMENT SET FOR APPLYING TT FIELDS
MX2024006036A (es) 2021-12-14 2024-06-05 Novocure Gmbh Desplazamiento de matriz de transductores para reducir la irritacion cutanea.
US12599761B2 (en) 2021-12-17 2026-04-14 Novocure Gmbh Systems and methods for removing and replacing conductive adhesive layers of an electrode array
CN114225215B (zh) * 2021-12-31 2023-05-05 湖南安泰康成生物科技有限公司 电极系统
CA3253015A1 (en) * 2022-02-25 2023-08-31 Hubbell Incorporated EXOTHORMIC REACTION METAL WELDING ASSEMBLIES AND METHODS OF USE
US20250170395A1 (en) * 2022-02-28 2025-05-29 Rhode Island Hospital Hydrogel conductivity impacts skin dose from tumor treating fields
KR102726242B1 (ko) * 2022-04-11 2024-11-04 가천대학교 산학협력단 경두개 직류자극술(tDCS)용 전극
US20240001134A1 (en) * 2022-06-30 2024-01-04 Novocure Gmbh Adhesive layer with protective border for use in a tumor treating fields transducer
US20240081939A1 (en) 2022-09-08 2024-03-14 Novocure Gmbh Constructing a 3d phantom with a matrix material having conductive particles dispersed therein
CN119947782A (zh) 2022-09-27 2025-05-06 诺沃库勒有限责任公司 用于测量内部TTField强度的可摄入且可植入的装置
CA3180284A1 (en) 2022-09-29 2024-03-29 Novocure Gmbh Transducer array having a temperature sensor isolation layer between a temperature sensor and external environment
IL320472A (en) 2022-11-30 2025-06-01 Novocure Gmbh Transducer arrays with alternative array materials
CN120417962A (zh) * 2022-12-28 2025-08-01 诺沃库勒有限责任公司 具有集成肿瘤治疗电场电压发生器的可穿戴服装
US12268863B2 (en) 2023-02-06 2025-04-08 Novocure Gmbh Shiftable transducer array with anisotropic material layer
US20240399141A1 (en) 2023-03-31 2024-12-05 Novocure Gmbh Microneedles to overcome contact resistance
WO2024254086A2 (en) * 2023-06-05 2024-12-12 New York University A distributed system for biosensing
TW202529847A (zh) 2023-09-28 2025-08-01 瑞士商諾沃庫勒有限責任公司 具有子陣列的換能器陣列及其製造和使用方法
WO2025068918A1 (en) 2023-09-29 2025-04-03 Novocure Gmbh Apparatus and method of reapplying transducer arrays to a patient
CN121925227A (zh) 2023-09-29 2026-04-24 诺沃库勒有限责任公司 低频射频消融系统
WO2025114837A1 (en) * 2023-11-30 2025-06-05 Solventum Intellectual Properties Company Article for securement to skin and method of use thereof
SE2450263A1 (en) * 2024-03-07 2025-09-08 Force Oncology Ab Personalized electrodes
TW202602517A (zh) * 2024-03-29 2026-01-16 瑞士商諾沃庫勒有限責任公司 在優先考慮特定方向下以多個方向對個體的身體施加交變電場
CN118384408B (zh) * 2024-06-28 2024-08-30 成都德而塔生物科技有限公司 一种防干扰的超声组合式贴片及超声治疗头
CN119792806B (zh) * 2025-02-26 2025-08-29 江苏海莱新创医疗科技有限公司 肿瘤电场治疗系统

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6263226B1 (en) * 1998-02-09 2001-07-17 Axelgaard Manufacturing Co., Ltd. Sponge electrode
US20160228691A1 (en) * 2013-09-16 2016-08-11 Koninklijke Philips N.V. Bio-medical electrode pad
CN107847732A (zh) * 2015-05-29 2018-03-27 赛威医疗公司 用于经皮电刺激的方法和装置
TW202011891A (zh) * 2018-06-15 2020-04-01 美商普羅托斯數位健康公司 可重複穿戴式生理監控裝置

Family Cites Families (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4437464A (en) * 1981-11-09 1984-03-20 C.R. Bard, Inc. Electrosurgical generator safety apparatus
FR2678094B1 (fr) 1991-06-20 1993-10-08 France Telecom Carte a memoire de comptage de donnees et appareil de lecture.
DK0643600T3 (da) 1992-06-02 1998-06-02 Alza Corp Iontoforetisk medikamentafgivelsesapparat
US5974344A (en) * 1998-03-02 1999-10-26 Shoemaker, Ii; Charles Wound care electrode
US6493588B1 (en) * 1998-03-18 2002-12-10 Mmc/Gatx Partnership No. 1 Electro-nerve stimulator systems and methods
US6347246B1 (en) 2000-02-03 2002-02-12 Axelgaard Manufacturing Company, Ltd. Electrotransport adhesive for iontophoresis device
US6868289B2 (en) 2002-10-02 2005-03-15 Standen Ltd. Apparatus for treating a tumor or the like and articles incorporating the apparatus for treatment of the tumor
US7089054B2 (en) 2002-10-02 2006-08-08 Standen Ltd. Apparatus and method for treating a tumor or the like
JP5280600B2 (ja) 2000-02-17 2013-09-04 パルティ、ヨーラム 分裂中の細胞を破壊するための方法および装置
US7599746B2 (en) 2000-02-17 2009-10-06 Standen Ltd Apparatus and method for preventing the spread of cancerous metastases and for elimination of metastases
US7146210B2 (en) * 2000-02-17 2006-12-05 Standen Ltd. Apparatus and method for optimizing tumor treatment efficiency by electric fields
US7890183B2 (en) 2000-02-17 2011-02-15 Novocure Ltd. Treating parasites with electric fields
US7016725B2 (en) 2001-11-06 2006-03-21 Standen Ltd. Method and apparatus for destroying dividing cells
US8313908B2 (en) 2000-02-23 2012-11-20 The Trustees Of The University Of Pennsylvania Regulation of stem cell gene production with specific and selective electric and electromagnetic fields
EP1235615B1 (en) 2000-08-24 2006-02-15 Unomedical Limited Biomedical electrodes and biomedical electrodes for electrostimulation
US6418333B1 (en) 2000-10-02 2002-07-09 Axelgaard Manufacturing Co., Ltd. Floating electrode
US20030153964A1 (en) 2001-05-01 2003-08-14 Polybiomed Limited Polymerizable material and sheet material derived therefrom
US7171276B2 (en) 2001-06-29 2007-01-30 Abbott Laboratories Hydrogel and scrim assembly for use with electro-acupuncture device with stimulation electrodes
JP4110527B2 (ja) * 2003-05-06 2008-07-02 日本光電工業株式会社 医療用電極
CA2563817C (en) 2004-04-23 2018-07-10 Yoram Palti Treating a tumor or the like with electric fields at different frequencies
WO2008032282A2 (en) 2006-09-13 2008-03-20 Compex Medical S.A. Electrode set and stimulating device
US8159312B2 (en) 2007-06-27 2012-04-17 Medrelief Inc. Method and system for signal coupling and direct current blocking
US8715203B2 (en) 2007-09-17 2014-05-06 Novocure Limited Composite electrode
KR20100028761A (ko) * 2008-09-05 2010-03-15 표대영 고주파 치료 장치용 전극 유닛 및 이를 포함한 고주파 치료장치
US8295902B2 (en) * 2008-11-11 2012-10-23 Shifamed Holdings, Llc Low profile electrode assembly
US8965534B2 (en) * 2012-09-13 2015-02-24 Covidien Lp Apparatus and method for energy distribution in a medical electrode
EP3498332B1 (en) * 2013-01-21 2021-07-14 Cala Health, Inc. Devices for controlling tremor
CN103585715B (zh) * 2013-11-22 2015-04-15 清华大学 一种集成中频电流电场刺激设备
AU2015271774B2 (en) * 2014-06-02 2020-04-16 Cala Health, Inc. Systems and methods for peripheral nerve stimulation to treat tremor
US10258788B2 (en) 2015-01-05 2019-04-16 Thync Global, Inc. Electrodes having surface exclusions
EP3067073A1 (en) * 2015-03-09 2016-09-14 Centre National De La Recherche Scientifique Method of forming a medical device comprising graphene
CN107580516A (zh) 2015-05-08 2018-01-12 皇家飞利浦有限公司 湿/干可转换电极以及其使用方法
DE102015012381A1 (de) * 2015-09-21 2017-03-23 Leonhard Lang Hydrogel, Herstellungsverfahren und medizinisches Gerät umfassend eine damit beschichtete Elektrode
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
GB201608691D0 (en) 2016-05-17 2016-06-29 Univ Southampton Electrode
EP3476429B1 (en) * 2016-06-27 2024-02-21 Sekisui Kasei Co., Ltd. Gel sheet
US20180001075A1 (en) * 2016-06-30 2018-01-04 Novocure Limited Arrays for Longitudinal Delivery of TTFields to a Body
WO2018081423A1 (en) * 2016-10-26 2018-05-03 Elira, Inc. Systems and methods for using a transcutaneous electrical stimulation device to deliver titrated therapy
DK3554631T3 (da) 2016-12-13 2022-05-30 Novocure Gmbh Behandling af patienter med ttfields med elektrodepositionerne optimeret under anvendelse af deformerbare skabeloner
US20200324107A1 (en) 2017-12-22 2020-10-15 Tohoku University Electrode body and production method for electrode body
US11058886B1 (en) * 2018-04-05 2021-07-13 Evanesc Therapeutics, Inc. Method of polarization control of evanescent waves for treating tumors
US11298422B2 (en) 2018-04-09 2022-04-12 Novocure Gmbh Treating tumors with TTFields and an aurora kinase inhibitor
WO2019197999A1 (en) 2018-04-10 2019-10-17 Zeev Bomzon Low frequency (<1 mhz) ac conductivity estimates derived from two mri images having different repetition times
US20190314638A1 (en) * 2018-04-17 2019-10-17 Inmode Ltd. Rf device for skin and fat treatment
WO2019209969A1 (en) 2018-04-24 2019-10-31 Thync Global, Inc. Streamlined and pre-set neuromodulators
US11890461B2 (en) * 2018-09-28 2024-02-06 Zoll Medical Corporation Adhesively coupled wearable medical device
KR102515448B1 (ko) 2018-10-01 2023-03-30 료지 쿠와하타 생체 자극 장치
KR102367898B1 (ko) * 2018-12-13 2022-03-02 주식회사 바른공학 드레싱 밴드
GB2584278B (en) * 2019-05-23 2024-02-14 Ablatus Therapeutics Ltd Conductive member for use in radiofrequency ablation
CN110180082A (zh) * 2019-07-01 2019-08-30 深圳明医医疗科技有限公司 中频治疗贴和中频治疗系统

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6263226B1 (en) * 1998-02-09 2001-07-17 Axelgaard Manufacturing Co., Ltd. Sponge electrode
US20160228691A1 (en) * 2013-09-16 2016-08-11 Koninklijke Philips N.V. Bio-medical electrode pad
CN107847732A (zh) * 2015-05-29 2018-03-27 赛威医疗公司 用于经皮电刺激的方法和装置
TW202011891A (zh) * 2018-06-15 2020-04-01 美商普羅托斯數位健康公司 可重複穿戴式生理監控裝置

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US20240165405A1 (en) 2024-05-23
US20210346693A1 (en) 2021-11-11
US12420089B2 (en) 2025-09-23
JP2023524532A (ja) 2023-06-12
TW202200232A (zh) 2022-01-01
US20240157133A1 (en) 2024-05-16
US20240157136A1 (en) 2024-05-16
WO2021226353A1 (en) 2021-11-11
US12465760B2 (en) 2025-11-11
US20240157131A1 (en) 2024-05-16
TW202537657A (zh) 2025-10-01
US12569677B2 (en) 2026-03-10
US20240157132A1 (en) 2024-05-16
US12472353B2 (en) 2025-11-18
CN116367881A (zh) 2023-06-30
US12427308B2 (en) 2025-09-30
US20240157134A1 (en) 2024-05-16
US12434052B2 (en) 2025-10-07
US20240165406A1 (en) 2024-05-23
US20240157135A1 (en) 2024-05-16
EP4146326A1 (en) 2023-03-15
US12440671B2 (en) 2025-10-14

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