TWI484181B - Method of justifying humidity effects in biosensor monitor with humidity sensor - Google Patents

Description

Method for automatically correcting humidity factor by biochemical detector

The invention relates to a method for automatically correcting a humidity factor by a biochemical detector, in particular, using a temperature detecting component and a humidity detecting component in a biochemical detector and inserting a test piece into the test piece to load the sample. The temperature and humidity parameters measured by the input temperature detecting component and the humidity detecting component, and the time and parameters of the time taken after the test strip is inserted into the sample, A compensation corresponding value is obtained from the database to reduce the measurement error caused by the humidity factor of the biochemical detector, so that the detection can be more accurate.

At present, the test piece applied by the electrochemical blood glucose detector is covered with a layer of the following dried reaction substance on the working electrode, the reference electrode or the auxiliary electrode of the reaction zone of the test piece, including: oxidase (Glucose Oxidase, GOD) Or Glucose Dehydrogenase (GDH) and conductive media such as Potassium Ferricyanide. When a sample (such as syrup or blood) is detected, the user can inhale the sample [such as blood] into the test strip reaction zone of the test piece by, for example, capillary action, and the oxidase on the test zone reaction zone. (Glucose Oxidase, GOD) or Glucose Dehydrogenase (GDH) and a conductive medium such as Potassium Ferricyanide, which reacts under an external supply voltage and is detected by The electrochemical reaction signal can be used to know the blood glucose concentration in the test sample.

Generally, the blood glucose test piece should be placed in a storage tank containing an appropriate amount of desiccant, because the red blood salt in the dried reaction substance on the test piece will absorb the moisture in the air and deteriorate, resulting in the measured blood sugar reading value rising. High, causing misjudgment by medical staff. In particular, when the user takes the test piece out of the drying tank, the red blood salt in the dried reaction substance on the test piece immediately absorbs the moisture in the air, and if the humidity in the atmosphere is slightly higher, the water absorbs faster. It will affect the measured readings. As shown in J. Diabetes Sci. Technol. v. 3(4); Jul 2009 "Increases in Whole Blood Glucose Measurements Using Optically Based Self-Monitoring of Blood Glucose Analyzers Due to Extreme Canadian Winters", in a hospital in Canada According to clinical trials, when the humidity of the water in the air rises, the average measured blood glucose reading will be high, which may easily cause misjudgment by medical personnel. Because patients with diabetes are extremely important for monitoring blood sugar levels, the relative accuracy requirements for biochemical detectors are relatively high. However, the test strips used in the biochemical detectors are extremely sensitive to humidity, often due to humidity. Improve and affect the accuracy of the final interpretation of the biochemical detector.

At present, the test strips are stored in a dry bottle jar that is isolated from the outside before use. When used, the user removes and uses the test strip, but after the user takes out the test strip, the test strip is in contact with the outside air. Biochemical reagents are affected by humidity. The longer the contact time with the outside world, the greater the detection error value. Because each biochemical detector user has different usage habits or different conditions, such as in use. When the user inserts the sample on the test piece immediately after inserting the test piece, the biochemical detector can immediately interpret the sample, and the time taken may be less than 5 seconds, but some elderly people, when inserting After the test piece is in the biochemical detector, the action is slow, so the time required to input the sample on the test piece may take several minutes, which may cause the biochemical detector to be misinterpreted.

However, at present, all commercially available blood glucose meters have the functions of automatic temperature compensation, but they do not have the above functions of automatically detecting humidity and performing reading compensation, and all the blood glucose instrument patents do not disclose the design method. Therefore, how to make the biochemical detector automatically correct the error caused by the humidity factor has become a problem that must be solved by such biochemical detectors.

In view of this, the inventors of the present invention have studied and disclosed the method for automatically correcting the humidity factor by the biochemical detector of the present invention.

The purpose of the present invention is to provide a method for automatically correcting humidity factors by a biochemical detector to reduce the measurement error caused by the humidity factor of the biochemical detector, so that the detection can be more accurate.

The method for automatically correcting the humidity factor by the biochemical detector disclosed by the invention includes:

(a) constructing a temperature sensing component and a humidity detecting component in the biochemical detector and a database corresponding to the compensation corresponding value of the time parameter of the test piece inserted into the test piece [because it is different In the case of temperature, the absorption characteristics of the test piece will be different. This database is a database for detecting the data obtained at different temperatures, exposed to different humidity, and different time under extremely strict environmental control.

(b) At the beginning of the test, the biochemical detector senses the atmospheric temperature and humidity parameters from a temperature sensing component and a humidity sensing component;

(c) starting from the insertion of the test piece into the biochemical detector, and when the test piece is loaded into the sample, the time is finished to obtain the parameter of the time taken for the test piece to be inserted until the test piece is loaded into the sample;

(d) The temperature and humidity obtained from (b) and (c), the parameters from the start of the test piece insertion to the time taken for the test piece to be loaded into the sample, and the database of item (a) is obtained to obtain a humidity compensation corresponding value;

(e) The measured value of the sample detected by the biochemical detector plus the compensation corresponding value of item (d) is displayed on the display of the biochemical detector to complete the automatic correction.

The method for automatically correcting the humidity factor by the biochemical detector disclosed by the invention can automatically compensate the detection error caused by temperature, humidity and operation factors, thereby improving the precision of the biochemical detector to improve product quality and competitiveness. , and its novelty and industrial use.

The method for automatically correcting the humidity factor by the biochemical detector disclosed in the present invention can be clarified by the following description and the accompanying drawings.

The invention relates to a method for automatically correcting the humidity factor of a biochemical detector, in particular to a method for reducing the measurement error caused by the temperature and humidity factors of the biochemical detector, so that the detection can be more precise.

The biochemical detector described above may refer to a blood glucose detector or other detector, and the invention does not limit the type and type of the biochemical detector.

The method for automatically correcting the humidity factor by the biochemical detector disclosed by the invention includes:

(a) constructing a temperature detecting component and a humidity detecting component in the biochemical detector and a database corresponding to the compensation corresponding value of the time parameter of the test piece inserted into the test piece;

(b) At the beginning of the test, the biochemical detector is induced by a temperature detecting component and a humidity sensing component to obtain atmospheric temperature and humidity parameters;

(c) starting from the insertion of the test piece into the biochemical detector, and when the test piece is loaded into the sample, the time is finished to obtain the parameter of the time taken for the test piece to be inserted until the test piece is loaded into the sample;

(d) The temperature and humidity parameters obtained from (b) and (c), and the parameters of the time taken for the test piece to be inserted into the test piece to be inserted into the test piece, and the database of item (a) is compared. Obtain a compensation corresponding value;

(e) The measured value of the sample detected by the biochemical detector plus the compensation corresponding value of item (d) is displayed on the display of the biochemical detector to complete the automatic correction.

The method for automatically correcting the humidity factor by the biochemical detector disclosed by the invention, wherein the humidity is related to the establishment of a database corresponding to the compensation value of the time taken for the test piece to be inserted into the sample, and the compensation corresponding value is Under extremely strict environmental control, detect the data obtained at different temperatures, exposed to different humidity, different time and then obtain the parameters; therefore, when it is known that the temperature, humidity and test piece insertion start to the test piece When the time taken into the sample takes time, the compensation corresponding value or the compensation corresponding value of the input parameter area can be obtained to automatically compensate the biochemical detector.

The test strips used in biochemical detectors are sensitive to the humidity of the atmosphere, so the test strips are usually stored in a dry bottle that is isolated from the outside and has a desiccant, but after the user removes the test piece The test piece is in contact with the outside air, and the biochemical reagent is affected by temperature and humidity. The longer the contact time with the outside world, the greater the detection error value; since each user of the biochemical detector has different usage habits, Or the condition of each use is different. For example, when using the sample, the user inputs the sample on the test piece immediately after inserting the test piece, so that the biochemical detector can immediately interpret the sample, and the time taken may be In less than 5 seconds, but some elderly people, after inserting the test piece in the biochemical detector, because the action is slow, so the time to input the sample on the test piece may take several minutes, so in the two cases, The difference between the influence of atmospheric humidity on the test piece is extremely great. The method for automatically correcting the humidity factor by the biochemical detector disclosed by the present invention is because the database established is based on temperature. The degree of humidity, the compensation value corresponding to the relationship between the insertion of the test piece and the time taken for loading the sample into the sample, so that the accuracy of each test can be accurately compensated for each user. The error caused by humidity.

The method for automatically correcting the humidity factor by the biochemical detector disclosed in the present invention can be implemented as shown in the first figure, and the central processing unit of the biochemical detector is connected to a database, temperature sensing component and humidity sense. The measuring component, when the user activates the biochemical detector, the temperature sensing component and the humidity sensing component can detect the temperature and humidity of the atmospheric environment, and input the measured temperature and humidity parameters into the central processing. In the unit, when the user inserts the test piece into the biochemical detector, the biochemical detector starts counting, and when the biochemical detector detects that the sample is input into the test piece [this detection method can be performed on the test piece A set of circuits is obtained by being turned on after receiving the sample, or can be obtained by other means, and the present invention is not self-limiting], so that the timing is finished, and it takes time to insert a test piece from the start of the test piece until the test piece is loaded into the sample. The parameters are input to the central processing unit, and the central processing unit compares each of the input parameters with the data in the database to obtain an appropriate compensation value for biochemical detection. The measured value is compensated by the detection subject, and after the numerical display in the compensation display, and this value would have been corrected to exclude the error due to temperature, humidity, operating time and other factors arising.

The method for automatically correcting the humidity factor by the biochemical detector disclosed by the invention can overcome the problem that the test piece affects the detection value due to atmospheric temperature, humidity parameter and operation factor, and the measurement precision of the biochemical detector applying the invention is accurate. The degree can be greatly improved to enhance the quality of the invention and to be competitive in the market, and the novelty and industrial applicability of the invention are apparent.

The method for automatically correcting the humidity factor by the biochemical detector disclosed in the present invention can be modified and applied without departing from the spirit and scope of the present invention, and the present invention is not limited.

First Figure: A block diagram of an embodiment of the present invention.

Claims (1)

A method for automatically correcting a humidity factor by a biochemical detector includes: (a) constructing a temperature detecting component and a humidity detecting component in the biochemical detector, and inserting a test strip into the test strip loading test (b) The biochemical detector detects the atmospheric temperature and humidity parameters from a temperature detecting component and a humidity detecting component; (c) and tests After the film is inserted into the biochemical detector, the time is counted, and when the test piece is loaded into the sample, the time is counted to obtain the parameter of the time taken for the test piece to be inserted until the test piece is loaded into the sample; (d) by (b) And (c) the atmospheric temperature and humidity parameters obtained from the two items, and the time parameters from the start of the insertion of the test piece to the time the sample is loaded into the sample, and the database of item (a) is compared to obtain a compensation corresponding value; (e) Add the sample measurement value detected by the biochemical detector to the compensation corresponding value of item (d) to complete the automatic calibration and display it on the display of the biochemical detector.