TWI284020B - Antibacterial compositions - Google Patents

Abstract

Antibacterial compositions having enhanced antibacterial effectiveness are disclosed. The antibacterial compositions contain a phenolic anti-bacterial agent, a surfactant or a disinfecting alcohol, and water, wherein a percent saturation of the antibacterial agent in a continuous aqueous phase of the composition is at least 25%.

Description

1284〇2〇

V. INSTRUCTION DESCRIPTION OF THE INVENTION (1) Field of the Invention The present invention relates to antimicrobial compositions having improved antibacterial efficacy, such as personal health care compositions, including hand sanitizing gels. More particularly, the present invention relates to antimicrobial compositions comprising an antibacterial agent, and a surfactant or a relatively small amount of a disinfecting alcohol, and which provides a significant reduction in the population of Gram-positive and Gram-negative bacteria within one minute, For example, more than 99%. BACKGROUND OF THE INVENTION Antibacterial personal care compositions are known in the art. Particularly useful are anti-W cleaning compositions which are generally used to cleanse the skin and destroy bacteria and other microorganisms present on the skin, particularly the hands, arms, and face of the user. Another type of antimicrobial personal care composition is a hand sanitizing gel. Such compositions are primarily used by medical personnel to sterilize hands and fingers. Hand disinfection

The gel is applied and rubbed onto the hands and fingers, allowing the composition to evaporate from the skin. It is not necessary to wipe the composition from the skin because the high alcohol content of the hand sanitizing gel today allows the composition to evaporate rapidly and essentially completely from the skin. , Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperatives, Print----7---------Installation--- (Please read the notes on the back to write this page). Line. Antibacterial composition is generally used. For example, the health care industry, the food service industry, the meat processing industry, and the private sector are used by individual consumers. The widespread use of antimicrobial compositions indicates that consumers place considerable emphasis on controlling the skin (bacteria and other microbial populations. However, it is important that the antimicrobial compositions provide rapid and non-toxic and skin irritation problems that provide significant and extensive reduction in the microbial population. In particular, antibacterial cleaning compositions generally contain an active antibacterial agent, interface

1284020 Α7 Β7 V. Description of invention (Printed by the Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperatives > Ancient agents, and various other ingredients, such as noodles, thickeners, skin conditioners, etc., are included in the aqueous carrier. Different types of antibacterial agents have been used in antibacterial cleaning compositions. Examples of antibacterial agents include biguanide (e.g., chlorhexidine digluconate), diphenyl compound, decyl alcohol, three __^_ Carbon hydrazine, tetraammonium compound, ethoxylated phenol, and phenolic compounds, such as halogen-substituted phenolic compounds, such as pcn€ (ie, p-chloro-m-xylenol) and tri-gas (ie, , 2,4,4,-trichloro _ 2, _ base-diphenyl ether. The current antimicrobial compositions according to such antibacterial agents have a wide range of antibacterial activity, ranging from low to high, depending on the microorganism to be controlled And the specific antimicrobial composition. The hand disinfecting gel contains a high percentage of alcohol, such as ethanol. The high percentage of alcohol contained in the gel is 'the alcohol itself is also used as a disinfectant. Can be quickly volatilized, eliminating the need to treat the disinfectant gel The skin is necessary for wiping or rinsing. A hand sanitizing gel containing a high percentage (i.e., about or above the weight ratio of the composition) alcohol tends to dry or irritate the skin. Second, most of the commercially available antibacterial The composition generally only provides low to moderate resistance to cockroaches. The antibacterial activity is evaluated against a wide variety of microorganisms, and has been negatively tested by the bacterial population of the antimicrobial composition, seven beta The β ^ / number reduction, or the percentage reduction of 疋 is related to the antibacterial activity phase / 疋 foot contact time, generally ranging from 15 seconds to 5 minutes, 1 "log reduction is the best," _3 reduction Preferably, it is the least preferred. Therefore, the highly preferred antimicrobial composition # (in the receiving room, against a wide variety of microorganisms, having 3-5

(Please read the note on the back to write this page) t! One SJ. 1 - Line 1284020 A7 B7 V. Invention description (3) The logarithm is reduced. The previous disclosure illustrates the attempt to provide such antimicrobial compositions which have so far failed to provide rapid, extensive microbiological control by consumers. > Wang Yi, at a pH of 4 and 9, a high log reduction has been achieved, but these log reductions are due, at least in part, to these relatively extreme pH values. Compositions having such pH will irritate the skin and other surfaces and are therefore generally avoided. This is especially the case for hand sanitizing compositions which are generally not wiped or rinsed from the skin after use. It has not been easy or impossible to achieve a high log reduction in the use of antimicrobial compositions having an intermediate pH of from about 5 to about 8, especially from about 6 to about 8, and not including a high percentage of alcohol. For example, WO 98/01110 discloses compositions containing triclosan, a surfactant, a solvent, a chelating agent, a thickening agent, a buffer, and water. W〇98/〇ii(1) relates to reducing skin irritation by using a smaller amount of surfactant.

A composition comprising PCMX and a selected surfactant is disclosed in U.S. Patent 5,635,462. The compositions disclosed therein are free of anionic interfacial activity, a non-ionic surfactant. WO 97/46218 and WO 96/06152 disclose compositions based on triclosan, organic acids or salts, solubilizers, and hydroxy solvents. EP 0 505 935 discloses compositions comprising PCDX in combination with nonionic and anionic interfacial activities, particularly nonionic block copolymer surfactants. WO 95/32705 discloses a mild surfactant combination which can be combined with an antibacterial compound such as triclosan. This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ----:----------Install--- (Please read the notes on the back first>|| !|Write this page) I. 1 Line · Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1284020 A7 B7 V. Invention Description (4) (Please read the note on the back before writing this page) W0 95/09605 reveals An anionic surfactant and an antimicrobial composition of an alkyl polyglucoside taste surfactant. WO 98/55096 discloses an antibacterial wipe having a perforated sheet impregnated with an antimicrobial composition comprising an active antibacterial agent, an anionic surfactant, an acid, and water, wherein the composition has from about 3.0 to about 6.0. pH value. NA Allawala et al.? J. Amer. Pharm. Assoc. - Sci. Ed.? Vol. XLII, no. 5? pp. 267-275, (1953) on the antibacterial activity of active antibacterial agents in combination with surfactants . A. G. Mitchell, J. Pharm. Pharmacol, Bol. 16, ρρ·533-537, (1964) discloses a composition comprising PCMX and a nonionic surfactant having antibacterial activity. The compositions disclosed in the Mitchell publication have antibacterial activity after a contact time of at least 47 minutes, and thus such compositions are not highly effective. In the case of hand-disinfecting gels, Osborne et al., U.S. Patent No. 5,776,430, discloses a topical antibacterial cleansing chlorin containing chlorhexidine and an alcohol. The compositions contain from about 50% to about 60% by weight of the denatured alcohol, and from about 0.65% to about 0.85% by weight of chlorhexidine. The composition is applied to the skin 'suck into the skin' and is washed away from the skin. The European Patent Application No. 0 604 848 of the Intellectual Property Office of the Intellectual Property Office of the Ministry of Economic Affairs discloses a gel type hand disinfectant containing an antibacterial agent, 40% to 90% by weight of an alcohol, and a combined weight of not more than 3% by weight. Compared to polymers and thickeners. The gel is applied to the hands and allowed to evaporate to provide a sterilized hand. The amount and type of antibacterial agent is not critical as described in EP 0 604 848, since the hand sanitizing gel contains a high percentage of alcohol to provide antibacterial activity. Such disclosed compositions generally do not provide immediate disinfection and do not provide residual antimicrobial efficacy. This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) l284〇2〇A7 B7 V. Description of invention (Issue of Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperative Printed 11:?: No antibacterial combination Which composition of the composition can be controlled by, for example, 囷. The previous composition is also not between about 5 and about 8:: especially at about 6 to about 8, providing effective , rapid, and control of a wide variety of bacteria. And because of its nature and surfactants are difficult to achieve for antibacterial = = composition. For example, several active anti-caries such as, 酉, have in water Too low solubility, for example, in three-rolled water, is about 5 to 10 ppm (one millionth of a ton: solubility can be increased by adding a surfactant to the composition:: The antibacterial dose in the composition..., 疋θ & is an increase in the antibacterial effect. In the case of any two specific theoretical limitations, it can be inferred that the surfactant activity depends on the resolution, but generally reduces the availability of the antimicrobial agent. Critical micelle of surfactant The concentration is ±, and the surfactant is formed into micelles. The critical micelle concentration of different surfactants is different. The formation of micelles is very important, because the micelles are lipophilic: touch: Γ and Dissolving the antibacterial agent, so that the antibacterial agent can not be obtained immediately when it is touched, and the bacteria can be controlled in a short time (ie, below). The late antibacterial agent in the surfactant microcapsules The fine whisker can be controlled for a longer period of time. If the antibacterial agent is free in an aqueous solution: 'and is not bound to the micelles of the surfactant (ie, two: Attracts to the lipophilic membrane of bacteria and rapidly demonstrates its work; &w is restrained in the micelles of the surfactant (ie, not -8 - paper size _ (CNS) ATii- (2i〇χ 297 ) (Please read the precautions on the back - write this page) • Line - 1284020 A7 B7 V. Description of invention (6) Activation) 'The antibacterial agent has only slow availability, and It is not possible to exhibit its function in a practical time for cleansing the skin. In addition, the antibacterial agent dissolved in the microcapsule can be washed. It is easy to wash away from the skin during the washing process and cannot adhere to the skin to provide residual antibacterial benefits. On the contrary, the antibacterial agent will be washed away and wasted. In the case of disinfection, the hand disinfecting gel generally contains: (a) At least a combination of ethanol or lower alcohol, such as ethanol and isopropanol, (b) water, (c) a gel polymer, such as a crosslinkable polyacrylate material, and (d) other ingredients, Such as skin conditioning agents, fragrances, etc. Hand disinfecting gels are used by consumers to clean the gel by rubbing it on the surface of the hand without washing it with soap or water, or after washing. Effectively disinfecting the hands. The two commercially available hand sanitizing gels rely on high levels of alcohol for disinfection and volatilization, thus having disadvantages. In particular, current hand sanitizing gels tend to dry or irritate the skin due to the high levels of alcohol used in the composition. At the same time, due to the volatility of ethanol, the main active disinfectant does not remain on the skin after use and thus does not provide sustained or residual antibacterial efficacy. Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperatives, Print----r----------Install--- (Please read the notes on the back to write this page) Line. In less than 60% alcohol At concentrations, ethanol is not considered a disinfectant. Therefore, in compositions containing less than 60% alcohol, additional antimicrobial compounds must be present to provide antimicrobial activity. However, the foregoing disclosure does not teach which composition of the composition of such an antimicrobial composition provides control of the bacteria. Therefore, in the case of a formulation containing a lower alcohol concentration, it is quite difficult to select an antibacterial agent which provides both rapid antibacterial action and sustained antibacterial benefit. The previous composition was also not at a neutral pH of from about 5 to about 8, especially at about 6 -9 - the paper scale applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 , invention description (7 to about 8 under the provision of a system. The fans, as well as the control of a wide variety of bacteria, therefore, still need a plug # # ▲ effect against a wide variety of two: t, which can be in a short time The antibacterial effect is mainly caused by the presence of the active antibacterial agent in the composition. The present invention relates to such antibacterial compositions. The present invention relates to the antibacterial composition. The antibacterial group of people, you, and the mouth, which can provide a significant reduction in the number of cells in the two-touch and the stagnation-negative bacteria in less than one minute. More specifically, in the eight a 本 the invention relates to the antibacterial a composition comprising an active anti-drug: a surfactant, a surfactant, and a water hydrazine. When measured at room temperature, the anti-#, 丨, 乂 to ^5〇/〇 saturation amount is present in a continuous In the aqueous phase (as opposed to being present in micelles). The invention also relates to antimicrobial compositions, It comprises an active antibacterial agent, a surfactant, a hydrazine, and a (iv) agent and/or a solubilizing agent, which is present in an amount of at least 25% saturation when measured at room temperature. In another embodiment Active antibacterial agent, disinfectant alcohol (please read the precautions on the back - write this page) *I5J· i line · Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed this invention relates to antibacterial composition, its package $ gel And an aqueous solution, wherein the antimicrobial agent is present in an amount of at least 5% by mole when at room temperature. The present invention relates to an antimicrobial composition comprising an active antimicrobial agent, a disinfecting alcohol, a granulating agent, a solubilizing agent, and water, wherein the antibacterial agent is present in an amount of at least 25% saturation when measured at room temperature. 'Thus' one aspect of the invention provides a liquid antimicrobial composition, ^ Contains: (a) from about 0.001% to about 10% by weight of the antimicrobial agent; (b) about %1% ^ -10- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 x 297 mm 1284020 A7 B7 V. Description of the invention (about 40% by weight of surfactant, selected from CfCi8 alkyl sulfate, & cis fatty acid salt, c8-C18 alkyl ether sulfate with 1 or 2 moles ethoxylated, C8-C18 alkylamine oxide, (8 < 18 alkyl creatinine) Salt, C8-C18 sulfoacetate, Cs-Ce cross-base glass salt, C8-C18 alkyl diphenyl oxide dicarboxylate, CVC1S alkyl carbonate, C8-C18 alpha olefin sulfonate a methyl ester sulfonate, and mixtures thereof; and (c) water, wherein the antimicrobial agent is present in the composition in an amount of at least 50% saturated concentration when measured at room temperature. The category provides an antibacterial composition of another specific example, wherein the composition comprises: (a) from about 0.001% to about 1%. a weight ratio of the antimicrobial agent; (b) from about 1% to about 40% by weight of the surfactant selected from the group consisting of an anionic surfactant, a cationic surfactant, a nonionic surfactant; an amphoteric surfactant, and a mixture thereof; (c) from about 〇% to about 30% by weight of a solubilizing agent; (d) from about 5% to about 25% by weight of a water-soluble solvent; and (e) water, wherein the composition contains a solubilizing agent And at least one of the hydroxy solvents, the Ministry of Economic Affairs, the Intellectual Property Office, the Employees' Cooperatives, when printed at room temperature, the antimicrobial agent is present in the composition in an amount of at least ::::2::. /辰度< Antibacterial combination of specific examples----.------------ (Please read the note on the back first to write this page) Ί-line · Another category of the invention Providing another article, wherein the composition comprises: (a) from about 0.001% to about 10% by weight of the antibacterial agent; (b) from about 10 to about 10% by weight of the interfacial active agent, cationic surfactant, non Ion ^ Interface Interacting Agent, Gendery -11 - Private Paper Scale Applicable to China National Standard (CNS) A4 Specification (210 x 297 mm) 1284020 A7 B7 Five Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed Invention Description () . Surfactants, and mixtures thereof; (please read the notes on the back before writing this page) (c) about 0% to about 40% by weight of solubilizer; (d) about 0% to about 60% by weight a water-soluble hydroxy solvent; and (e) water, wherein the composition contains at least one of a solubilizing agent and a light solvent in an amount sufficient to dissolve the antibacterial agent, and wherein when measured at room temperature, the antibacterial agent is An amount of at least 25% saturation concentration is present in the composition. Another embodiment of the present invention provides a liquid antimicrobial composition comprising: (a) from about 0.05% to about 5% by weight of an antimicrobial agent; (b) from about 1% to about 40% by weight of a disinfecting alcohol , for example, a C1-6 alcohol; (c) from about 0.01% to about 5% by weight of a gelling agent, such as a colloidal or polymeric gelling agent; and (d) water, wherein when measured at room temperature, The antimicrobial agent is present in the composition in an amount at least 50% saturated. Still another aspect of the invention provides an antibacterial composition of another embodiment, wherein the composition comprises: (a) from about 0.05% to about 5% by weight of an antimicrobial agent; (b) from about 1% to about 40% a weight ratio of the disinfecting alcohol; (c) from about 0.01% to about 5% by weight of the gelling agent; (d) from about 0.1% to about 30% by weight of the solubilizing agent; and (e) water, wherein when at room temperature The antimicrobial agent is present in the composition in an amount of at least 25% saturation concentration when measured. Still another aspect of the present invention provides an antibacterial composition of another specific example, wherein the composition comprises: -12- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 Ministry of Economy Intellectual Property Bureau Staff Consumer Cooperatives Print 5, Invention Description (1()) (a) about 0.05% to about 5% by weight of the antibacterial agent; (b) about 1% to about 40% by weight of the disinfectant alcohol, And (c) water' wherein the composition contains a disinfecting alcohol and a selective scent, Gu Gang, in an amount to dissolve the antimicrobial agent' and wherein the resistance is at least 25% saturated when measured at room temperature The amount is present in the composition. Further, the present invention provides an antibacterial composition which, after contact, has a logarithmic reduction of at least 2 against Gram-positive bacteria (i.e., Staphylococcus aureus). Providing an antibacterial composition which is resistant to Gram-negative bacteria after contact in seconds (i.e., the logarithm of the large intestine-like red s less than 2. 5 is reduced. A composition which has a significant logarithmic reduction against Age-positive and Gram-negative bacteria and a pH of about 8. 〃 ^ 'Another aspect of the invention provides a consumer product of an antimicrobial composition according to the invention, For example, 'skin cleansers, body sprays, surgical scrubs, wound care agents, hand sanitizing gels, disinfectants, mouthwashes, pet shampoos, hard surface disinfectants, etc.. A method of contacting a tissue, such as a 'dermis, with a composition of the present invention, on a tissue of an animal, including a human group, such as a 'stain' positive and/or a gram-negative bacterial population, such as, for example, 15 seconds to 5 minutes) to reduce the amount of bacteria to the desired amount and provide residual control for the amount of bacteria. This combination can be applied from the skin to the Chinese National Standard (CNS) A4 specification. (2) χ χ 公 爱 爱 羟 , , , ------ ------ ------ ------ ------ ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( 1284020 V. INSTRUCTIONS (11) Wipe or wash off the object. In the section > 胄td + 产士南丨刀,, in the case, it allows the composition to stay on the skin until the composition Volatile components are volatilized. 1 The personal health care products of the individual green-protected oral health supplements have been known for many years. Since the introduction of antibacterial personal health care products, the central government, p Gu Er also # ·,,. Chen please declare that these products provide anti-caries properties. However, if it is necessary to become a valid woman in A County, the antibacterial composition should provide a high logarithm against a wide variety of microorganisms during the short contact time of T. Reduced/acting. Antibacterial compositions such as shai can provide residual bacterial control, which is also beneficial. As the current *7 'matcher' commercial 1 liquid antibacterial sputum composition only provides the effect of killing bacteria to the limit of low to low, that is, the rate of killing bacteria. Table! Summary of commercially available products Killing effect, each containing 〇2% to 〇3% by weight of triclosan (an antibacterial agent) and surfactant. ----:----------Installation - (please first Read the notes on the back\|1^Write this page) · Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperatives Printed Table Commercial Liquid Hand Wash Soap Time-killing Product Microorganism (log reduction after 1 minute contact time) Positive S. aureus Negan E. coli Negan K. pnenm. Commercial product A 0.39 0.00 0.04 Commercial product B 2.20 0.00 0.01 Commercial product C 1.85 0.00 0.00 -14- -Line - This paper size applies China National Standard (CNS) A4 Specification (210 X 297 mm) 131284020 A7 B7 V. Description of the Invention (Saturation/Chenness in the Printing of the Consumers' Cooperatives of the Intellectual Property Office of the Ministry of Economic Affairs. The surfactant not only increases the solubility of the compound in the continuous aqueous phase of the composition, it also forms micelles and allows the compounds to be dissolved in the micelles. The % of the bacteriostatic agent is saturated in any composition, including a composition containing a surfactant, and is preferably expressed as: % saturated = [C/Cs] x 〇〇 % wherein the C-based antimicrobial agent is in the composition Concentration, and q is the saturation concentration of the antimicrobial agent in the composition at room temperature. Without wishing to be bound by any theory, Applicants believe that the continuous aqueous phase in the surfactant-containing composition is in equilibrium with the micelles of the far composition, while at the same time, any dissolved foot species such as, antibacterial activity The agents are distributed between the water continuous phase and the micelle pseudo phase according to the distribution law. Thus, the percent saturation of the antimicrobial active in the composition, or the relative thermal activity or relative chemical potential, is the same throughout the composition. Therefore, the saturation percentages of the antibacterial agents "in the composition", "in the composition water continuous phase", and "in the composition micelle pseudo phase" are used interchangeably, and are used as disclosed herein. in. When the difference in thermodynamic activity between the composition and the macro-organic active agent is maximized (i.e., when the active ingredient of the composition is more saturated with r), a large antibacterial effect can be achieved. The second factor affecting the antimicrobial activity is the total amount of the available antimicrobial agent, which can be considered a "critical dose." It has been found that given the same thermodynamic activity, the total level of active agent in the continuous aqueous phase of the composition can greatly affect the time to achieve the desired amount of antimicrobial efficacy. Therefore, two important factors affecting the antibacterial efficacy of the active agent in the composition are: This paper scale applies the Chinese National Standard (CNS) A4 specification (210 X 297 public) t Please read 53 on the back and note the matter--- Write this page) Order: Line · 1284020 A7 B7 V. Description of invention (14) (1) Its availability, which is determined by its thermal activity, that is, its composition (please read the note on the back first) Write this page) in % of the aqueous phase < saturation percentage, and (2) the total amount of active agent in solution. An important component of the sputum cleaning composition is a surfactant which acts as a solubilizing agent, a cleaning agent, and a foaming agent. The surfactant can affect the percent saturation of the antimicrobial agent in the falling liquid or, more importantly, the percentage of saturation of the active agent in the continuous amount of water in the composition. This effect can be explained in the context of very low water solubility antimicrobial agents in aqueous surfactant solutions which are distributed between the water (i.e., continuous) phase and the micelle pseudophase. For antibacterial agents with too low water solubility, such as triclosan, the distribution is strongly biased towards micelles (i.e., relative to the aqueous phase, most of the triclosan molecules are present in the surfactant microgel) In the grain). The ratio of surfactant to antimicrobial agent directly determines the active dose present in the surfactant micelles, which in turn affects the saturation and percentage of the active agent in the continuous aqueous phase. It has been found that as the proportion of surfactant/active agent increases, the number of micelles relative to the active molecule also increases, with the proportion of such micelles being less saturated with the active agent as the ratio increases. = The active agent in the continuous aqueous phase is in equilibrium with the active agent in the microcapsule pseudo-phase, and the saturation phase of the antibacterial agent in the micelle phase is reduced with the Ministry of Economic Affairs, the Intellectual Property Office, and the continuous phase φ _ r The anti-caries agent saturation is also reduced. vice versa. The active agent dissolved in the microcapsule pseudophase is not immediately available upon contact with the microorganism, and the antibacterial activity of the composition is determined by the percentage of saturation of the active agent in the coincidence phase. However, the active agent in the surfactant can act as a reservoir for the active agent to replenish the continuous aqueous phase when the active agent is depleted. ^ -17- 1284020 A7 -------B7 V. INSTRUCTIONS (16) At room temperature, at least about 25% of the antimicrobial agent in the continuous aqueous phase is saturated. These compositions had a log reduction of about 2 against the Gram-positive bacteria after 30 seconds of contact. These compositions had a log reduction of about 25 against the Gram-negative bacteria after 3 seconds of exposure. Important non-limiting specific examples of the invention are described below. A. Anti-Composition Anti-Composition In one embodiment of the present invention, the antibacterial composition contains an active antibacterial agent, a surfactant, and water. The composition of Specific Example A has a rapid bacterial killing effect, even in the absence of a hydroxy solvent and a solubilizing agent. The presence of the hydroxyclay and/or solubilizer does not adversely affect the antimicrobial properties of the composition' but such optional ingredients are not essential ingredients. Such compositions may further comprise other optional ingredients as disclosed hereinafter, such as conditioners, dyes, and perfumes. 1. Antimicrobial Agents Antibacterial strains are present in the compositions of the present invention in an amount of from about 1% to about 1% by weight, and more preferably from about 0.01% to about 5% by weight of the composition. To achieve the full advantage of the present invention, the antimicrobial agent is present in a weight ratio of from about 5% to about 2% of the composition. Such antimicrobial compositions may be ready-to-use compositions which generally comprise from 0.001% to about 2%, preferably from about 5% to about 5%, and most preferably from about 5% to about the weight of the composition. Compared to antibacterial agents. These antimicrobial compositions can also be formulated as a concentrate which can be diluted with about 1 part to about 100 parts of water prior to use to provide a final use composition. Such concentrated compositions typically contain greater than about 01%, and up to about 10% by weight of the antimicrobial agent. The present application also encompasses those in which the end use composition contains greater than 2% by weight of the antibacterial agent. This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 public):---------------Installation--- (Please read the note on the back first HI writing Page) Order · Line - Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1284020 Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed

A7 V. Description of the invention (as discussed above, the anti-caries agent present in the group of gentlemen u?, σ, < absolute content is not as good as the available antibacterial agent in the compound ^^, into θ. ^Α Further, ηΐ is important. The available antibacterial agent in the composition<the inner layer and the interface in the composition, the amount of the active agent t, the amount of the surfactant in the composition, and the composition selection The existence of sexual components is related. The fight is the fine killing effect of achieving the target in a short contact time, such as 15 to qing, medium, 'the antibacterial contained in the continuous aqueous phase of the composition when measured at room temperature. The dosage is at least about 5%, and preferably at least about 75%, of the saturated concentration of the antimicrobial agent in water. To achieve the full advantage of the present invention, the continuous aqueous phase is about 95% to 100% saturated with the antimicrobial agent. The amount of antimicrobial agent in the continuous aqueous phase can be defined by subtracting the total amount of antimicrobial agent in the composition from any antimicrobial agent present in the surfactant micelle. The method for determining the percent saturation of the antimicrobial agent in the composition is disclosed The antibacterial agent which can be used in the invention is a phenolic compound It can be exemplified by the following types of compounds: (a) 2-3⁄4 benzyl diphenyl compound (OK) wherein Y is a chlorine or bromine, Z system is S02H, N02, or Crc4 alkyl, to 3 to 3, 〇 0 Up to 3, p is 〇 or 1, m is 0 or 1, and η is 0 or 1. In a preferred embodiment, γ is gas or desert, m is 0, η is 〇 or 1, 0 is -20- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm)

| .----------Install---_----_--Book----_---Ί-Line· (Please read the note on the back first HI write this page) A 1284020 A7 B7 V. INSTRUCTIONS (18 1 or 2, r is 1 or 2, and p is 〇. In a particularly preferred embodiment, Y is chlorine, melon is 〇, 11 is 〇r 2, and p System 0. A particularly useful 2-hydroxydiphenyl compound has the structure: lanthanide 1 C1 OH Cl which has the name diclosan, and can be marketed under the trade name IRGASAN DP3 from Ciba Specialty Chemicals Corp., Greensboro, NC. Commercially available. Another useful 2-hydroxydiphenyl compound is 2,2,-dihydroxy-5,5,-dibromodiphenyl ether. (b) Anthracene derivatives

(Please read the precautions on the back m to write this page.) Ministry of Economic Affairs, Intellectual Property Bureau, Staff and Consumer Cooperatives, which prints Ri hydrogen, hydroxy-based, CrC4 alkyl, chlorine, nitro, phenyl, or ^, R2 a hydrogen, a sulphur group, a base, or a halogen atom; a hydrogen group, a Ci (macro group, a thiol group, a gas, a nitro group, or a metal salt or a salt); the R4 is hydrogen or a methyl group; Hydrogen or nitro. Halogen is bromine or, preferably, chlorine. Specific examples of phenol derivatives include, but are not limited to, chlorophenol (o-, _, • 21 - this paper scale applies to China National Standard (CNS) A4 size (210 X 297 mm) 1284020 A7 B7 V. Description of invention (19) For hydrazine, 2,4-dichlorophenol, p-nitrophenol, picric acid, xylenol, p-chloro-inter-di Cresol, cresol (o-, m-, p-), p-chloro-m-cresol, catechol, resorcinol, 4 · n-hexyl resorcinol, hydrazine, 2, 3 · Hydroquinone, phloroglucinol, carvacrol, thymol, p-chlorothymol, o-phenylphenol, o-nonylphenol, p-chloro-o-benzylphenol, phenol, 4 _Ethylphenol, and 4-wasonic acid. Other phenols The organisms are listed in WO 98/55096, which is incorporated herein by reference. (c) Diphenyl compounds----------------------- Matters HI write this page)

« . wherein X is sulfur or methylene, and the core and % are hydroxyl groups, and R 2 , R 2 , 2, R, 3, R 4 , R 4 , R 5 , and r 5 are each independently hydrogen or a halogen atom. Specific non-limiting examples of diphenyl compounds are hexachlorobenzene, tetrachlorobenzene, dichlorobenzene, 2,3-dihydroxy-5,5'-dichlorodiphenyl sulfide, 2,2, dihydroxy-3, 3,5,5,-tetrachlorodiphenyl sulfide, 2,2'-dihydroxy-3,5',5,5,6,6,'hexachlorodiphenyl sulfide, and 3,3,_ 2 Bromo 5,5, di- gas-2,2'-dihydroxydiphenylamine. Other diphenyl compounds are listed in WO 98/55096, which is incorporated herein by reference. 2 · Interface activity over ι| In addition to the antibacterial agent, the antibacterial composition also contains a surfactant. The interfacial active agent is present in a weight ratio of from about 1% to about 40%, and preferably from about 3% to about 2% by weight of the composition. In order to achieve all the advantages of the present invention, the antibacterial composition contains -22- the paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) • Line” Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed 1284020 A7 B7 20 V. Description of the invention (having from about 0.5% to about 15% by weight of the surfactant. The ready-to-use composition generally contains from 1% to about 1%, preferably from about 3% to about 5%, and Preferably, from about 5% to about 3% by weight of the composition. The concentrated composition suitable for dilution generally contains greater than about 5% by weight of surfactant. The amount of surfactant present in the composition is in the composition. The content and type of the antibacterial agent and the type of the surfactant are related. The content of the surfactant is determined such that the saturation percentage of the antibacterial agent in the aqueous phase of the composition is at least about 50%, preferably at least about 75%, and most Preferably, at least about %%. In this particular example, wherein the presence of a hydroxy solvent and a solubilizing agent is selected, the type of surfactant provides a composition having at least about 5% by weight of the antimicrobial agent in the continuous aqueous phase. It’s very important. As after The surfactants useful in this embodiment of the invention include anionic surfactants and selected cationic surfactants. Nonionic surfactants and anionic surfactants containing relatively high amounts of ethoxylation. Not specifically exemplified in this particular example. Ethoxylated surfactants containing more than 2 moles of ethylene oxide have a strong affinity for the antimicrobial agent, and in this particular example significantly reduce the efficacy of the antimicrobial agent. In an embodiment, the surfactant is selected from the group consisting of the following types of surfactants: cvc! 8 mercapto sulfate, CrCi8 fatty acid salt, C8_CM alkyl ether sulfate with j or 2 mole ethoxylation, alkylamine oxidation A Cs cls: k-based sarcosinate, CfCu transverse acetate, C8_C18 contiguous succinic acid = C8_C18 alkyl diphenyl oxide disulfonate, (: 8 <: 18 alkyl carbonate 8 18 α L-acid salt, methyl ester salt, and mixtures thereof. The C8-C18 thiol group has 8 to 16 carbon atoms and can be a direct bond (eg, 12-alkyl) (please read the back note first) Matter 3 write this page)

I I P Ministry of Economics, Intellectual Property, Bureau of Employees, Consumers, and Consumers Co., Ltd. 23 1284020 A7 B7 V. Ministry of Economic Affairs, Intellectual Property Office, Staff Consumer Cooperative, Printed Description (21) or branched (eg, 2-ethyl-hexyl). The cation of the anionic surfactant may be an alkali metal (preferably sodium or potassium), ammonium, CrC4 alkyl ammonium (mono-, di-, tri-), or (^-(^alkanol ammonium (single- , di-, tri-). Lithium and alkaline earth cations (eg, magnesium) may be used, but the antibacterial efficacy may be reduced. Specific surfactants that may be used in this specific example include, but are not limited to, taudecyl sulfate, Octyl sulfate, 2-ethylhexyl sulfate, dodecyl oxide, sulfhydryl sulfate, tridecyl sulfate, cocoate, dodecyl sarcosine, twelfth base Acrylate, linear C1Q diphenyl oxydisulfonate, dodecyl sulfosuccinate, lauryl ether sulfate (1 and 2 molar ethylene oxide), tetradecyl sulfate Salts, oleates, stearates, resinates, oxidized cocoamines, guanamines, tetradecylamines, ricinoleates, cetyl sulfates, and similar surfactants. Other examples can be found in ''CTFA Cosmetic Ingredient Handbook,'* JM Nikitakis, ed.? The Cosmetic, Toiletry and Fragrance Ass Ociation, Inc., Washington, DC (1988) (hereinafter referred to as CTFA Handbook), p. 10-13, 42-46, and 87-94, which is incorporated herein by reference. The carrier comprises water. 4. Optional Ingredients The antimicrobial compositions of the present invention may also contain optional ingredients well known to those skilled in the art. For example, the compositions may contain hydroxy solvents and/or solubilizing agents. The optional ingredients and the amounts which may be present in the compositions are discussed below. These compositions may also contain other optional ingredients such as dyes and fragrances 24-- ----. ----Install--- (Please read the note on the back HI to write this page) · · ·! Line k This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 , invention description (22 Ministry of Economic Affairs, Intellectual Property Bureau, employee consumption cooperatives, printed scented agents, which exist in sufficient quantities to demonstrate their intended function, and do not adversely affect the antibacterial efficacy of the composition. These selective ingredients are generally Respectively from 0% to about 5% by weight of the composition, and totaling from 〇% to about 2 〇% composition by weight ratio. The types of optional ingredients include, but are not limited to, dyes, fragrances, pH adjusters, thickeners, viscosity modifiers, buffers, foam stabilizers, antioxidants, foams Enhancers, chelating agents, opacifiers, and similar types of selective ingredients known to those skilled in the art. Specific types of optional ingredients include alkanolamine as a foam enhancer and stabilizer; gums as thickeners and Polymer; inorganic phosphate, sulfate, and carbonate as a buffer; EDTA and phosphate as a chelating agent; and acid as a pH adjuster. Examples of preferred types of illustrative pH adjusting agents include ammonia; mono-, di-, and tri-alkylamines, mono-, di-, and tri-alkanolamines; alkali metal and alkaline earth metal hydroxides; Its mixture. However, the type of alkaline pH adjusting agent is not limited, and any of the qualitative pH adjusting agents known in the art can be used. Specific non-limiting examples of the assay pH adjusting agent include ammonia; sodium, potassium, and lithium hydroxide; monoethanolamine; Z ethylamine; isopropanolamine, diethanolamine; and triethanolamine. Examples of preferred types of acidic pH adjusting agents include inorganic acids and polycarboxylic acids. Non-limiting examples of the acid include hydrochloric acid, nitric acid, scaly acid, and sulfuric acid. Non-limiting examples of poly, citric acid include citric acid, glycolic acid, and lactic acid. The acidity of the pH is not limited, and any acid pH chelating agent known in the art can be used alone or in combination. ---1 —----------装--- (Please read the note on the back HI to write this page) . · -25- :^ Zhang scale for China-nnnn - 1284020 A7 B7 DESCRIPTION OF THE INVENTION (23) The chain-smelting amine which provides thickening, foaming, and foaming stability to the composition may be 'but not limited to' cocoamine MEA, cocoa amine DEA, soybean decyl DEA, cinnamon SS Amine DEA, oleic acid MIPA, stearylamine MEA, myristyl MEA, cinnamylamine MEA, decyl DEA, castoramine DEA, myristyl DEA, stearylamine DEA, oil 醯Amine DEA, tallow amine DEA, cinnamylamine MIPA, tallow amine MEA, isostearylamine DEA, isostearylamine MEA, and mixtures thereof. B · Containing i bacteria, surfactant, hydroxy solvent and/or solubilizer ^ Antibacterial composition In another embodiment, the antibacterial composition contains an active antibacterial agent, a surfactant, and a hydroxy solvent and/or a solubilizing agent . The composition of Specific Example B has a rapid bacterial killing effect and does not substantially limit the type of surfactant in the composition. The solvent and/or solubilizer assists in dissolving the antimicrobial agent and reduces the affinity of the antimicrobial agent to enter the surfactant micelles. Therefore, regardless of the type of surfactant, a saturation of at least 25% of the antimicrobial agent in the aqueous phase can be achieved. 1. Antibacterial Agent The antibacterial agent content and type present in the specific examples of the present invention are as discussed in the above A.1. In addition, in order to achieve the target bacterial killing effect in a short contact time, such as 15 to 6 seconds, the continuous aqueous phase of the composition contains an antimicrobial dose when measured at room temperature. The saturated concentration of water is at least about 25%, and preferably at least about 50%, and more preferably at least about 75%. In order to achieve all the advantages of the present invention, the long-term performance of the aqueous phase is about 1% of the antibacterial agent. -26- This paper scale applies the Chinese National Standard (CNS) A4 specification (210 X 297 public) ---- ------------Installation (please read the note on the back first H write this page) I tmme ^1· I ϋ a- ·! em- _ Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 1284020 A7 V. INSTRUCTIONS (24 The Ministry of Economic Affairs, Intellectual Property Office, Staff Consumer Cooperative, Printed Saturated. 2. Surfactant In this particular example of the invention, the content of A 2am surfactant is the same as that of A 2 The same. 炊..., 七如田..., and because of the presence of smear and/or solubilizer, the type of surfactant is not as limited as in Α2. In particular, hydroxy solvents and/or solubilizers ( Its presence as defined below reduces the affinity of the antimicrobial agent to enter the surfactant micelles. Therefore, regardless of the type of surfactant, there is a sufficient amount of antimicrobial agent in the continuous aqueous phase. Effectively kill a wide variety of bacteria. In the specific examples of #solvent and solubilizer in t, various circles A surfactant, such as an oxylated nonionic surfactant, has a high affinity for the antimicrobial agent, so that the antimicrobial agent cannot be obtained by rapid bacterial reduction. The shot is an anionic surfactant, a cationic surfactant, a nonionic surfactant, and a compatible mixture of interfacial active agents. The surfactant may also be an amphoteric surfactant, which may be based on the pH of the composition. And having anionic or cationic properties. Accordingly, the antimicrobial compositions may contain anionic, surfactants as disclosed in VIII.2 above, and more generally may comprise any anionic interface: a hydrophobic agent having a hydrophobic Part, such as a carbon chain comprising from about 8 to about 30 carbon atoms, and especially from about 12 to about 20 carbon atoms, and further having a hydrophilic moiety, such as sulfates, sulfonates, carbonates, Phosphate, or a carboxylate. Typically, the hydrophobic carbon chain is etherified, such as with ethylene oxide or glycidene, to produce specific physical properties, such as increased water solubility. Zhang scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) (Please read the notes on the back page » Write this page: Packing. 丨 line) 1284020 A7 B7 V. Description of invention () Solution or reduction for The surface tension of the anionic surfactant. Accordingly, suitable anionic surfactants include, but are not limited to, compounds of the following type: alkyl sulfates, alkyl ether sulfates, alkyl ether sulfonates, alkanes Sulphate of phenoxy polyoxyethylene ethanol, α-olefin sulfonate, ^-alkoxy alkane sulfonate, alkylaryl sulfonate, alkyl monoglyceride sulfate, alkyl ether carboxylate , fatty acid, sulfosuccinate, sarcosinate, oxtoxynol or nonoxynol phosphate, crotonate, fatty bovine decylamine, fatty acid guanamine, oxyethylene sulfonate, isethionate, or mixtures thereof. Other anionic surfactants are listed in McCutcheon's Emulsifiers and Detergents, 1993 Annuals, (hereinafter referred to as McCutcheon's), McCutcheon Division, MC Publishing Co., Glen Rock, NJ, pp. 263-266, incorporated herein by reference. . A variety of other anionic surfactants, as well as anionic surfactants, are disclosed in U.S. Patent No. 3,929,678 to Laughlin et al., which is incorporated herein by reference. Printed by the Ministry of Economic Affairs, Intellectual Property Bureau, Staff and Consumer Cooperatives -----;---------- Packing - (Please read the note on the back first, write this page) Line, these antibacterial compositions can also be Contains a nonionic surfactant. Generally, the nonionic surfactant has a hydrophobic group, such as a long chain alkyl or alkylated aryl group, and a hydrophilic chain comprising a sufficient number (i.e., from 1 to about 30) of ethoxy groups. And / or propoxy. Examples of nonionic surfactants include ethoxylated alkyl phenols, ethoxylated and propoxylated fatty alcohols, polyethylene glycol ethers of methyl glucose, polyethylene glycol ethers of mannitol, Ethylene oxide-propylene oxide block copolymer, ethoxylated ester of fatty (C8_C18) acid, condensation product of ethylene oxide with long chain amine or decylamine, and mixtures thereof. Examples of nonionic surfactants include, but are not limited to, methyl glucose ether-10, PEG-20 methyl glucose distearate, PEG-20 methyl glucose -28 - the paper scale applies to Chinese national standards ( CNS)A4 specification (210 X 297 mm) Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 1284020 A7 B7 V. Invention description (26) Semi-hard fat salt, Cl 1_15 key pit acid -20, 10 7T pit base Bond-8, hexadecyl ether-12, dodoxynol-12, dodecyl ether-15, PEG-20 castor oil, polysorbate 20, octadecyl ether-20, polyoxyethylene oxime - 10 hexyl decyl ether, polyoxyethylene-10 octadecyl ether, polyoxyethylene-20 hexadecyl ether, polyoxyethylene- ίο oil ether, polyoxyethylene-20 oleyl ether, ethoxylated cesium Phenol, ethoxylated octylphenol, ethoxylated dodecyl phenol, or ethoxylated fat (C6-C22) alcohol, including 3 to 20 ethylene oxide moieties, polyoxyethylene oxime - 20 isohexadecyl ether, polyoxyethylene-23 glyceryl dodecanoate, polyoxyethylene-20 glyceryl stearate, PPG-10 methyl glucose ether, PPG-20 methyl glucose ether, polyoxyethylene -20 dehydrated sorbose Alcohol monoester, polyoxyethylene-80 castor oil, polyoxyethylene-15 tridecyl ether, polyoxyethylene-6 tridecyl ether, dodecyl ether-2, dodecyl ether-3, Dodecyl ether-4, PEG-3 castor oil, PEG600 dioleate, PEG400 dioleate, and mixtures thereof. Many other nonionic surfactants are disclosed in McCutcheon's Emulsifiers and Detergents, 1993 Annuals, published by McCutcheon Division, MC Publishing Co., Glen Rock, NJ, pp. 1-246 and 266-272; CTFA International Cosmetic Ingredient Dictionary, Fourth Ed., Cosmetic, Toiletry and Fragrance Association, Inc., Washington, DC (1988) (hereinafter referred to as CTFA Dictionary), p. 1-651; and CTFA Handbook, p. 86-94; This article serves as a reference. In addition to anionic and nonionic surfactants, cationic and amphoteric surfactants can also be used in such antimicrobial compositions. Cationic surfactants include amine oxides, for example. Amphoteric surfactants can be widely described as derivatives of secondary and tertiary amines, -29- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) il--T------ ---- Installed - (Please read the note on the back first, Amjc write this page) . • f 1284020 A7 B7 V. Inventive Note (27) It has a linear or branched aliphatic group, and these One of the aliphatic substituents contains from about 8 to 18 carbon atoms, and at least one of the aliphatic substituents contains an anionic water-soluble group such as a carboxyl group, a sulfonate, or a sulfate. Examples of the compounds recited herein include sodium 3-(dodecylamino)propionate, sodium 3-(dodecylamino)-propane-1-sulfonate, and 2-(dodecylamino). Ethyl sulphate, sodium 2-(dimethylamino)ethyl sulfate, sodium 3-(N-carboxymethyl-dodecylamino)-propane-1 -sulfonate, octadecyl Disodium amide diacetate, 1 · renetropic methyl-2_ eleven burning base. Sodium 'and N,N-bis(2-3⁄4ylethyl)-2-sulphate-3-dodecyloxypropylamine sodium. More specifically, a type of amphoteric surfactant comprising sarcosinate and taurate has a structural formula 0

II

Ri-C-N-(CH2)n.Y

I R2 wherein Ri is Cu to C21 alkyl, R2 is hydrogen or CrC2 alkyl, Y is CO 2 M or SO 3 M, lanthanide is metal, and η is a number 1 to 3. Another type of amphoteric surfactant has the structural formula 0 S03-Na+

II I

Ri-NHCCH2-CH-C02-Na+ can also be used with the following types of amphoteric surfactants: -30- This paper size applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) (please read the notes on the back first) Ml write this page) -1 ---[----一-订---J-----线- Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 1284020 A7 B7 V. Invention description ( 28

〇II CH2C〇2_Na+

R1CNHCH2CH2N

CH2CH2OH alkyl amphoteric glycinate Ο CH2C02-Na+ R1CNHCH2CH2NCH2C02H ch2ch2oh alkyl amphoteric carboxylglycine 〇 CH2CH2C02-Na+

RiCNHCH2CH2N I ch2ch2oh Alkyl amphopropionate CH2CH2C02_Na+ Η (Please read the note on the back first - write this page)

Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed ricnhch2ch2nch2co2 CH2CH2OH alkyl amphocarboxypropionate-31 - This paper scale applies to China National Standard (CNS) A4 specification (210 297 297 mm) 1284020 A7 Ministry of Economic Affairs Intellectual Property Bureau staff consumption Co-operative printing ____B7_;_ 99 V. Invention description () OHI O CH2CHCH2S03-Na+ II I ricnhch2ch2n ch2ch2oh succinyl propyl sulphate o ch3 II I R1CNH(CH2)3N+-CH2C02- ch3 alkanoylpropyl Methylammonium lactone 〇ch3 ohII II R1CNH(CH2)3N+-CH2CHCH2S03-ch3 alkalamine propyl hydroxysulfonate sultaine 〇II RiNHCH2CH2C-0_Na+ alkylaminopropionate (please read the back first) Precautions ml write this page) Loading ·. .Ί线· -32- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 ___B7___L___ V. Invention description (3G) ch2ch2co2-

I ----Γ----------装--- (Please read the note on the back first to write this page)

RNH

I ch2ch2co2h alkyliminopropionate. Other types of amphoteric surfactants include trimethylammonium lactone and phosphinines. Specific non-limiting examples of the amphoteric surfactants that can be used in the present invention include the N-methyl taurine coconut sodium, the N-methyl taurine oil sodium, the N-methyl group. Taurine sodium oleate, sodium N-methyltaurate, sodium cocodimethyl carboxymethyltrimethylammonium lactone, lauryl dimethyl carboxyethyl trimethyl ammonium lactone, sixteen Alkyldimethylcarboxymethyltrimethylammonium lactone, dodecyl-bis-(2-hydroxyethyl)carboxymethyltrimethylammonium lactone, oleyl dimethyl-T-carboxypropyltrimethylammonium lactone , dodecyl-bis-(2-hydroxypropyl)-carboxyethyltrimethylammonium lactone, cocoguanamine dimethyl propyl sulfonic acid trimethylammonium lactone, octadecyl decyl dimethyl dimethyl Trimethylammonium propyl sulfonate, trimethylammonium lactadide-bis(2-hydroxyethyl)propyl sulfonate, disodium oleic acid PEG-2 sulfosuccinate, TEA oil Amidoxime PEG-2 sulfosuccinic acid, oily amine MEA sulfosuccinate disodium, oily amine MIPA sulfosuccinate disodium, valeramine MEA sulfosuccinate disodium, undecyl decylamine MEA sulfosuccinate disodium, malt Amino-based MEA succinic acid disodium succinate, isostearyl guanamine MEA sulfosuccinate disodium, cocoa amphoteric glycinate, cocoa amphoteric carboxylate, dodecyl ampholactic acid, twelve Alkyl amphocarboxyglycinate, octyl amphocarboxyglycolate, cocoa amphoteric propionate, cocoa amphocarboxypropionate, dodecyl amphocarboxyl-33- _____ This paper scale applies to Chinese national standards ( CNS)A4 specification (210 X 297 public) 1284020 A7 B7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 5, invention description (31) acid salt, octyl amphoteric acid propionate, di-vinyl ethyl tallow Amine, 3-hydroxypropylphosphoric acid trimethylammonium lactone cocoaguanamine disodium, 3-hydroxypropyl phosphate dimethyl methoxide * 酉 十一 11 11 11 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 14 g Shengjilin, such as trimethylammonium lactone, dodecyltetradecylguanidinium disodium, 3-hydroxypropylphosphoric acid, trimethyl lactone, dodecyl group, tetradecyl amide, guanylamine, bisphosphonate, trimethyl phosphite Ammonium lactone cocoamidopropyl monosodium, trimethylammonium phosphite lauryl dodecyl decyl guanidinopropyl And mixtures thereof. 3. Carrier The carrier in this specific example contains water. 4. Selective Ingredients The optional ingredients discussed in the above paragraph 4 may also be used in this particular embodiment of the invention for the same amount and for the same purpose. 5 · Light Solvent and Solubilizer One embodiment of the present invention comprises from about 5% to about 25% by weight of a hydroxy solvent, and from 0% to about 30% by weight of a solubilizing agent, wherein the antimicrobial composition contains a hydroxy solvent and increases At least one of the solvents. Preferred embodiments include both a solvent and a solubilizer. Preferred embodiments contain from about 2% to about 20% by weight of the hydroxy solvent, and/or from about 2% to about 25% by weight of the solubilizer. The most preferred embodiment contains from about 5% to about 15% by weight of the hydroxy solvent, and/or from about 5% to about 20% by weight of the solubilizer. A "solvent" as defined herein is a water-soluble organic compound containing from 1 to 6, and typically from 1 to 3 hydroxyl groups. The vocabulary "hydroxyl solvent" thus includes water-soluble alcohols, glycols, triols, and poly-34- (please read the note on the back of this page). ··! Line · This paper scale applies to Chinese national standards ( CNS) A4 size (210 X 297 mm) 1284020 A7 B7 32 V. Description of the invention (Alcohol. Specific examples of hydroxy solvents include, but are not limited to, methanol, ethanol, isopropanol, n-butanol, n-propanol , ethylene glycol, propylene glycol, glycerin, diethylene glycol, dipropylene glycol, tripropylene glycol, hexanediol, butanediol, 1,2,6-hexanetriol, mannitol, pEG_4, and the like A solubilizer is a compound which has the ability to enhance the water solubility of other compounds. The solubilizer used in the present invention lacks surfactant properties and is generally a short-chain alkaryl sulfonate. Specific examples of solubilizer include, but not Limited to 'sodium cumene sulfonate, ammonium cumene sulfonate, ammonium xylene sulfonate, potassium traversate, sodium toluene sulfonate, potassium diphenyl sulfonate, toluene sulfonic acid, and xylene Other available solubilizers include sodium polysulfonate, poly Phenylacetate%, sodium methyl sulphate, and disodium succinate. C. Straightening agent, and antimony and/or anti-caries agent. In yet another embodiment, The antibacterial composition contains an active antibacterial agent, and a hydroxy solvent and/or a solubilizing agent. The composition of the specific example c has a rapid bacterial killing effect, and also does not substantially limit the surfactant in the composition. // or a solubilizing agent can assist in dissolving the antibacterial agent. Therefore, even in the absence of a surfactant, a saturation of at least 25% of the antibacterial agent in the continuous aqueous phase can be achieved. The presence of τ 尸 / Γ 在 & & & & & & & & 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷 囷Bactericidal killing effect, when measuring the paper scale at room temperature, applicable to China's national standard - i;---------- loaded i - (please read the note on the back first to write this page) $ · Economy Ministry of Intellectual Property Bureau employee consumption cooperative printing -35-1284020 Α7

5. Description of the Invention (33) The antibacterial dose of the continuous aqueous phase of the attack, and the six substances is at least about 25% of the saturated concentration of the antibacterial agent in water, and preferably at least about Na, and more preferably about y is about 75. % » To achieve the full advantage of the present invention, the continuous aqueous phase is about 95% to 1% saturated with the antimicrobial agent. 2 · Interface Active Sword The surfactant is an optional component in this specific example. However, when f is present, the surfactant present in the specific examples of the invention herein is about 0% soil. The weight t匕 is preferably from 〇% to about 5% by weight. In order to achieve the advantages of the king of the month, the surfactant is present in an amount of 〇〇/〇 to about by weight due to the presence of each/valley and/or solubilizing agent. The type is the same as the surfactant disclosed in B. 2. 3 · _ carrier - The carrier in this specific example contains water. 4. The optional components of the above-mentioned A · 4 may also be used in the same embodiment of the invention for the same amount and the same purpose. 5 · and solubilizer; text B · $ 娜 到 and the technical solvent and solubilizer can also be used for the same purpose 2 t Μ < this _ specific examples. However, the content of the dissolved and/or solubilizing agent in the specific example may be higher than that disclosed in the above-mentioned β·5, since the additional field, the carboxyl group/valley and/or the solubilizing agent may be present in the absence of the surfactant. In the case where it is necessary to stabilize the antibacterial agent. Thus, in a specific example C, the composition may comprise from about 5% to about 6% by weight of a hydroxy solvent, and from about 〇% to about 4% by weight of a solubilizer. However, the _-36- two-foot size specification (21. χ 297 ~----------------- installed--- (please read the note on the back first to write this page ) - Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed 1284020 A7 B7 34 V. Description of the Invention (The composition contains at least one of a hydroxyl solvent and a solubilizer. Preferred embodiments include about 2 ° / to about 20% The weight ratio of the hydroxy solvent, and/or the solubilization of about 2% to about 25% by weight. The preferred embodiment of the oxime contains from about 5% to about 15% by weight of the non-ubiquitent agent' and/or a solubilizing agent in a weight ratio of from about 5% to about 2% by weight. The most preferred embodiment contains both a hydroxy solvent and a solubilizing agent. D. Box - an antibacterial composition having an antibacterial agent, a rabbit and a second gelling agent in another In a specific example, the antibacterial composition contains an active antibacterial agent, a disinfecting alcohol, and a gelling agent. The composition of the specific example D has a rapid bacterial killing effect. The composition of the specific example D is an excellent hand disinfectant. 1 · Antibacterial Sword The type of antibacterial agent present in the specific examples of the present invention is as described above, in the case of Α·1. In this specific example, the antibacterial agent is about 〇〇5〇/. to 25%, and preferably from about 0.1% to about 4% by weight of the composition. ^, about the full advantage of the present invention, the antimicrobial agent is about 25 〇 /. Approximately 2% of the two ingredients are present in an amount. Weight 2. Carrier The carrier of the present composition comprises water. 3. Disinfecting alcohol The antibacterial composition of the present invention contains from about 1% to about 4% by weight. Preferably, the specific example contains from about 2% to about % by weight of the weight of the mixture. The preferred embodiment of the disinfecting alcohol contains from about 5% to about 3% by weight of the disinfecting alcohol. The term "disinfecting alcohol" is a water-soluble mixture containing from 1 to 6 carbon atoms. The disinfecting alcohol includes, but is not limited to, pre-alcohol, a, methanol, alcohol, propanol, and isopropanol. This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) (please read the note on the back to write this page) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 351284020 Α7 Β7 V. Invention Description (4 Gels The antimicrobial compositions of the present invention comprise from about 0% to about 1% by weight, preferably from about 0.10%. A gelling agent of about 3% by weight. To achieve all of the advantages of the present invention, the antimicrobial compositions comprise from about 25% to about 2.5% by weight of a coffee agent. The antimicrobial compositions generally contain a sufficient amount. a gelling agent to make a group of people a viscous liquid, gel, or semi-solid that can be easily applied and applied to the skin. Those skilled in the art will recognize the gelation and levels of gels that should be included in the composition to provide The viscosity or consistency of the target composition. Here and in the following, the term "gel" refers to a compound that enhances the viscosity of a water-based composition, or can convert a water-based composition into a compound of the gel. Thus, the gelling agent can be of an organic nature, such as a natural gum or a synthetic polymer, or can be inorganic in nature. As stated previously, the compositions of the present invention are free of surfactants. The interface activity of 5 ^ 1 is not sufficient to be added to the antibacterial composition of the present invention, but may be present in an amount of about 5% by weight of the gamma, since the surfactant may be present in a commercially available form of the gel, Helps disperse the gel in water. The surfactant may also be present in the form of additives or by-products of other composition ingredients. The surfactant is omitted from the present composition to help avoid the formation of micro-particles. The micelles dissolve the active antimicrobial compound and reduce its efficacy. Also, a preferred gelling agent is particularly one which does not form a micelle, and which does not compound or combine with the active antimicrobial agent, or which does not adversely affect the antibacterial properties of the antimicrobial product 1J. Regardless of the type of gelling agent, the amount of gelling agent and other component ingredients is selected such that the antimicrobial agent is present at a level of at least 25% saturation when measured at room temperature. -38- This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) ----r----------Install--- 请Please read the note on the back first This page) I. Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1284020 A7

Non-limiting examples of the following gels can be used in the present invention, and the following compounds, including organic and helmets, and the like, mainly rely on the fine substance <aqueous part Thickening or agglutination: Acacia, acrylate/dodecyl ether 2 bismuth, agar, ammonium alginate, alginic acid, ammonium acrylate ammonium, ammonium sulfate, amylopectin, attapulgite, bentonite Calcium acid, calcium alginate, calcium carrageenan, calcium carbonate, octanol 910, carboxyvinyl preparation 934, carboxyvinyl preparation 934p

_, carboxy acetamidine formulation 94 carboxymethyl hydroxyethyl cellulose:: mouth guar guar, carrageenan, cellulose, cellulose gum, (10) ketol cetyl alcohol, corn starch, Dama resin, dextrin, dimercapto mannitol, ethyl dihydrogenated tallowamine, ethyl dioleamide, ethyl stearylamine, gelatin, guar gum, guar hydroxypropyl Chlorinated - gamma, pyroxene, hyaluronic acid, hydrated vermiculite, hydroxybutyl methylcellulose, hydroxyethyl '" 灭' primed & ethyl ethyl cellulose, light ethyl stearylamine - mipa, light I Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperatives Printed olefinic acid 5 ammonium sulphate, I C9-15 alcohol, fragrant 'Polycarboxylated poultry carboxy

Cellulose, hydroxypropyl guar, hydroxypropyl methylcellulose, whale 4 alcohol, isostearyl alcohol, karaya gum, seaweed ash, cinnamyl alcohol, hedgehog" gum, aluminum magnesium niobate, tannic acid Magnesium, magnesium tricaprate, methoxy pEG 2 〇 / dodecaethylene glycol copolymer, methyl cellulose, microcrystalline cellulose, montmorillonite, decyl sterol, oat flour, oleyl alcohol, palm kernel Oil, pectin, PEG-2M, PEC 5M, polyacrylic acid, polyvinyl alcohol, potassium alginate, aluminum polyaluminum silicate, keratin, potassium chloride, potassium sulfate, potato starch, propylene glycol alginate , sodium propionate/vinyl alcohol copolymer, sodium carboxymethyl dextran, carrageenan, sodium cellulose sulfate, sodium chloride, sodium polymethacrylate, yttrium aluminate-39- China National Standard (CNS) A4 Specification (2) χ χ 公 Public Love) 1284020 A7 B7 V. Description of Invention (Sodium, Sodium Sulfate, Stearic Acid Bentonite, Stearin, Hectorite, Stearyl Alcohol, Tallow Alcohol) TEA·HCl Compound, tragacanth, tridecyl alcohol, trimethylamine hard acid magnesium, wheat flour, wheat starch, xanthan gum, and mixtures thereof. Other non-limiting examples of agents function primarily by thickening the non-aqueous portion of the composition: rosin alcohol, propionate oleic acid, aluminum behenate, aluminum distearate, isostearic acid/cinnamic acid/ Standard acid or aluminum stearate, isostearic acid / myristic acid, isostearic acid / aluminum palmitate, isostearic acid / aluminum stearate, aluminum lanolate, myristic acid / palmitic acid Aluminum, aluminum stearate, aluminum stearate, aluminum tristearate, beeswax, behenamide, camelliaol, butadiene/acrylonitrile copolymer, X C29_70 acid, calcium catechin, calcium stearate, Candelilla wax, carnauba wax, pure wax, cholesterol, biliary hydroxystearate, coconut alcohol, samarium resin, diglyceryl stearate malate, rosinol, dimethyl Dodecyl oleate, dodecanoic acid / cetearyl alcohol / ethylene glycol copolymer, mannosamine, ethyl cellulose, glyceryl triethylene hydroxy stearate, glyceryl triethyl hydrazide Sesame oleate, ethylene glycol dibehenate, ethylene glycol dioctanoate, ethylene glycol distearate, hexanediol distearate, hydrogenated to seven hydrocarbon polymers, Hydrogenated castor oil, hydrogenated cottonseed oil, hydrogenated lard, hydrogenated eucalyptus oil, hydrogenated palm kernel oil glyceride, hydrogenated palm kernel oil, hydrogenated palm oil, argonized polyisobutylene, hydrogenated soybean oil, hydrogenated tallow amine, hydrogenated tallow Glycerides, hydrogenated vegetable glycerides, hydrogenated vegetable glycerides, hydrogenated vegetable oils, propyl cellulose, isobutylene/isoprene copolymers, iso-p-stearone stearates, Japanese waxes, aloe waxes, wool Aliphatic alcohol, laurylamine, methyl dehydroabietic acid ester, methyl hydrogenated abietic acid ester, methyl rosinate, and a paper grade applicable to China National Standard (CNS) A4 specification (210 X 297 mm) -1 -------------装--- (Please read the note on the back to write this page) LSJ· · Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed 1284020 A7 χ^---- ^--_ V. Description of invention (38) Benzene/Ethylene-toluene copolymer, microcrystalline wax, montanic acid wax, montan wax, myristyl eicosanol, myristyl stearyl alcohol, 18 Alkene/maleic anhydride copolymer, octyl lauryl stearate stearate, oleylamine, oil stearin, Crown Brazilian palm wax, oxidized polyethylene, ceresin, palmitol, paraffin, pentaerythritol hydrogenated rosinate, pentaerythritol rosinate, pentaerythritol tetracyanate, pentaerythritol Octanoate, pentaerythritol tetraoleate, pentaerythritol tetrastearate, phthalic anhydride/glycerol/glycidyl, phthalate copolymer, phthalic acid//triphenylbenzene Formic acid/ethylene glycol copolymer, ice butylene, polybutylene terephthalate, polydipentene, polyethylene, polybutene, polyisoprene, polyvinyl butyral, polyethyl cinnamic acid Ester, propylene glycol dicaprylate, propylene glycol dicocoate, propylene glycol diisodecanoate, propylene glycol dicinnamate, propylene glycol dicaprate, propylene glycol distearate, propylene glycol heptaester, pyp/ten Hexacarbon-based copolymer, rice bran wax, PVP/cetene copolymer, stearin bentonite, stearin, hectorite, hard decylamine, stearylamine DEA-distearate, stearylamine DIBA - stearate, stearylamine MEA-stearate, stearyl ketone, stearyl alcohol, stearyl stearylamine, stearyl stearate, stearyl Lipidyl stearate, synthetic beeswax, synthetic wax, trihydroxystearin, triisoxanthine, triisostearyl, diisonon, triisostearyl, triisostearyl trilinoleic acid Ester, tri-cinnamon, tri-linoleic acid, tri-alkali, tri-myristyl, triolein, tripalmitin, distearyl, zinc cinnamate, zinc myristate, zinc neodecanoate, zinc rosinate, Zinc stearate, and mixtures thereof. 5 · Selective ingredients a. Multi-solvent • 41 - This paper scale applies to National Standard (CNS) A4 (210 X 297 public) ---- ------------- --装--- (Please read the note on the back to write this page) Set. Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed 391284020 A7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 5, invention description (more solvent-free 'If present, the product, 々αΐ/. to about 50%, and preferably from about 5% to the weight of the composition of the composition, is present. To achieve all of the advantages of the present invention, the multi-(four) agent is about The weight ratio of the brain to the composition of the composition is present. Unlike the disinfecting alcohol, the multi-light solvent has only a minor contribution to the antibacterial efficacy of the composition of the invention, as it contributes. As defined herein, the term "polyhydroxyl solvent" a water-soluble organically synthesized mouth having 2 to 6 s and generally 2 to 3 sulfhydryl groups. The term "water-soluble" means that the solvent is at least 每 每 水 under the pit.克^合片] The water, the degree of solution. There is no upper limit to the solubility of water in a polyhydroxy solvent. For example, the polyhydroxy solvent and water can be used in the It is soluble in proportion. The stagnation of the sacred antelope thus covers water-soluble diols, triols, and polyols. Specific examples of polyhydric solvents include, but are not limited to, ethylene glycol, glycerol , monoethylene glycol, dipropylene glycol, tripropylene glycol, hexanediol, butyl decoxide, 2,6-hexanediol, mannitol, peg-4, and similar years old stem-based compounds. The addition system, if present, is present in an amount of from about 1% to about 3%, and preferably from about 5% to about 25 parts by weight of the group & weight ratio. To achieve all of the advantages of the present invention' The multi-light solvent is present in an amount by weight of from about 1% to about 2% by weight of the composition. The type of the emollient agent is as discussed in B. 5 above, and is used for the same purpose for the same purpose. Specific examples. c. Other optional ingredients Other optional ingredients discussed in the above paragraph 4 may also be used in the same amount and the same purpose for this specific example of the present invention. China National Standard (CNS) A4 specification (heart 297 public).—•IV----------装--- (Please read the note on the back first) Page) Η-Τ· 线. 1284020 A7 B7 V. INSTRUCTIONS (Other optional ingredients that may be used in this specific example include skin conditioning agents. Examples of skin conditioning agents include softening agents such as silky soil based myristic acid vinegar, Glyceryl dioleate, isopropyl myristate, lanolin, methyl cinnamic acid vinegar, PPG-9 cinnamate, soy stearyl, octyl palmitate, and PPG-5 wool vinegar For example, the skin treatment agent may also be a humectant such as 'glucosamine and pyridoxine. For example, an inclusive skin preparation agent such as 'lanolinic acid corn oil, methic〇n, coconut may also be used. Oil, stearyl stearate, phenyl trimethic, n-myristyl, olive oil, and synthetic soil. Combinations of various types of skin conditioning agents can also be used, in addition to the various skin conditioning agents known to those skilled in the art, either alone or in combination. Non-limiting examples of various skin conditioning agents include aloe vera, cholesterol, cystine, keratin, phospholipid, egg yolk, glycine, PPCM2, retinol, salicylic acid, whey acid, vegetable oil, and soluble animals. Collagen. The skin conditioning agent can be used alone or in combination with a skin protectant such as petrolatum, cocoa butter, zinc paste, and kaolin, for example. Skin protectants can also be used alone. Other examples of skin conditioners and skin protectants can be found in CTFA c〇smetic

Ingredient Handbook/JM Nikitakis, ed., The Cosmetic, Toiletry and Fragrance Association, lnc., Washington, Dc (1988) (hereinafter referred to as CTFA Handb〇〇k), p 79-85, which is incorporated herein by reference. literature. The antibacterial composition of the present invention comprising an active antibacterial agent, a disinfecting alcohol, and a solubilizing agent has a rapid bacterial killing action. The alcohol and solubilizer assist in dissolving the antimicrobial agent. Thus, at least 25% saturation of the antimicrobial agent in the composition can be achieved even in the absence of surfactant. The antibacterial composition of the present invention does not rely on low pH or high pH to provide the bacterial family - III - - - - I - Ml · II (please read the note on the back to write this page) Bureau employee consumption cooperative printed -43-

1284020 A7 B7 V. INSTRUCTIONS (41) _ Rapid reduction of groups. The antimicrobial compositions of the present invention may have a pH of from about 4 to about 9, but at both extremes of the pH range, the compositions may irritate the skin or otherwise damage other surfaces that are contacted by the composition. Thus, the antibacterial composition of the present invention preferably has a pH of from about 5 to about 8, and more preferably from about 6 to about 8. To achieve the full advantage of the present invention, the antimicrobial compositions have a pH of from about 6.5 to about 7.5. Further, the antibacterial composition of the present invention is also independent of the anti-toxic alcohol of the south. To illustrate the novel and unexpected results provided by the antimicrobial compositions of the present invention, the following examples and comparative examples were prepared and tested for their ability to control Gram-positive and Gram-negative bacteria. The weight percentages listed in the following examples represent the actual, or active, weight of each component of the composition. These compositions are prepared by mixing the ingredients, as will be apparent to those skilled in the art, and as described below. The following materials were used as ingredients in the examples. The source of each component, and its abbreviations, are summarized below: a) Alkyl (linear) diphenyloxy dicarboxylate, Pilot Chemical Co., Santa Fe. Springs, CA, CALFAX 101-45 (Active =45.4%), b) alkyl polyglucose (APG), Henkel Corp., Hoboken, NJ, PLANTAREN 2000N UP (activity = 55.53%), c) continued acid a-hydrocarbon (AOS), Stepan Chemical Co· , Northfield, IL, BIOTERGE AS-40 (activity = 38.80%), d) ammonium lauryl sulfate (ALS), Henkel Corp., STANDAPOL A (activity = 28.3%),

e) Ammonium xylene sulfonate (AXS), Stepan Chemical Co., STEPANATE AXS -44- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) ---------- ----^ (Please read the note on the back to write this page) --^—Book--------- Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 1284020 A7 B7 V. Invention description () (activity = 40%), f) cocoamidopropyl betaine (CAPB), McIntyre Group, Ltd., Chicago, IL, MACKAM 35-HP (estimated 30% active betaine), g Dipropylene glycol (DPG), Dow Chemical Co., Midland, MI, h) Dodecyl ether, succinic acid, sodium sulphate (DSLScct), McIntyre Group, Ltd., MACKANATE EL (activity = 33.8%), i ) 12 烧 基 基 基 基 ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( ( (approximately 55% active), k) DowFax solubilizer solution (DFX), Dow Chemical Co., DowFax Hydrotrope Solution (benzene, 1,1 '-oxybis-, second-hexyl derivative, acidification) Salt) (activity estimate = 45.7%), l) glycerol (GLY), Henkel/Emery, Cincinnati, OH, Emery 916 Glycerine (99.7% CP/USP), m) isopropanol (IP A), Fisher Scientific, Pittsburgh ,PA,2-Propanol,HPLC Grade A 451-4, n) Oxidized dodecylamine (LAO), McIntyre Group, Ltd., MACKAMINE L〇 (activity = 30.55%), o) Liquid essence (PF), p ) Lithium lauryl sulfate (LLS), Henkel, TEXAPON LLS (activity = 28.8%),

q) Magnesium Sulfate Magnesium Sulfate (MLS), Stepan Chemical Co., STEPANOL -45- This paper scale applies to China National Standard (CNS) A4 specification (210 x 297 mm) ---I------ ----Install (please read the note on the back to write this page) --^--Book----.---- Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 1284020 A7 — B7 V. Invention Description () . MG (activity = 28.3%), r) methyl sulfonate (MES), Stepan Chemical Co., ALPHA-STEP ML-40 (potassium methyl 2-sulfolaurate and 2-sulfolauric acid) Dipotassium) (activity = 36.47%), s) monoethanolamine (MEA), Dow Chemical Co., t) dodecyl sulfate monoethanolamine (MEALS), Albright & Wilson, Cumbria, England, EMPICOL LQ 33/F (activity = 33%), u) octylphenol ethoxylate, 9-10 Mo EO (TX100), Union Carbide, TRITON-X-100, v) PEQ-6ME, polyethylene glycol 300 methyl ether, From Dow Chemical Co., Midland, MI, obtained with MPEG 350 (activity = estimated 100%), w) Poloxymer 338 (F108), BASF, Wyandotte, MI, PLURONIC F108 (activity = estimated 100%), x) cocoa Potassium (KCO), McIntyre Group, Lt d·, MACKADET 40-K (activity = 38.4%), y) potassium laurate (KL), prepared from cinnamic acid (Sigma, #L-4250, activity = 99.8%) and potassium hydroxide, z) potassium oleate (KO), Norman, Fox & Co., Vemon, CA, NORFOX KO (activity = about 80%), aa) propylene glycol (PG), Dow Chemical Co., USP Grade (activity = 99.96%), bb) 2 -ethylhexyl sulfate (S2EHS), Henkel, SULFOTEX OA (activity = 39.68%), cc) CirC18 sodium sulfate (SC12-18S), Henkel, TEXAPON ZHC needles -46· This paper scale applies to the Chinese National Standard (CNS) A4 size (210 x 297 mm) --------------- Pack--- (Please read the note on the back first to write this page) Order: Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative Printed 1284020 A7 B7 44 V. INSTRUCTIONS () (activity = 90.95%), dd) sodium cocoamphoacetate (SCA), McIntyre Group, Ltd., MACKAM IC-90 (activity = about 32%), ee) Sodium propylbenzenesulfonate (SCS), Stepan Chemical Co., STEPANATE SCS (activity = 44.6%), ff) sodium decyl sulfate (SDecS), Henkel, SULFOTEX 110 (activity = 30.80%), gg) Thioglycolic acid sodium (SLSa Rc), Hampshire Chemical Co., Lexington, MA, HAMPOSYL L-30 Type 724 (activity = 29.9%), hh) sodium lauryl ether sulfate, 1 mole EO (SLES-1), Henkel, STANDAPOL ES- 1 (activity = 25.40%), ii) sodium lauryl ether sulfate, 2 mol EO (SLES-2), Henkel, STANDAPOL ES-2 (activity = 25.71%), jj) sodium cinnamate/12 Sodium Alkyl Sulfate (SLS/SDS), BDH Biochemical, BHD Ltd” Poole, England (activity = 99.0%), kk) Sodium decyl thioacetate (SLSA), Stepan Chemical Co., LANTHANOL LAL (activity = 72.65%), 11) sodium octyl sulfate (SOS), Henkel, STANDAPOL LF (activity = 32.90%), mm) sodium salt of NEODOX 23-4 (NDX23-4), Shell Chemical Co., derived from NEODOX 23- 4, which is a compound having a molecular weight chain of 194, 4 moles of E〇, and a monocarboxylic acid group (activity = 32.90%), nn) sodium tridecyl sulfate (SC 13S), Rhodia, Parsippany, NJ, RHODAPON TDS (activity = 24.65%), -47- This paper size is applicable to China National Standard (CNS) A4 specification (210 297 297 mm) (please read the note on the back to write this page) Binding: Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed 1284020 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed A7 B7 V. Invention description (45) 00) Sodium xylene sulfonate (SXS), Stepan Chemical Co., STEPANATE SXS (activity = 40 -42%), pp) Triclosan (TCS), IRGASAN DP-300, Ciba Specialty Chemicals Corp., Greensboro, NC (GC analysis for batches of households = 99.8-99.9% active TCS; mp = 56.0- 58.0 C·), qq) triethanolamine lauryl sulfate (TEALS), Henkel, STANDAPOL T (activity = 40.1%), rr) tripropylene glycol (TPG), Dow Chemical Co., Tripropylene Glycol (activity = 99.96%) , ss) p-chloro-m-xylenol (PCMX), NIPACIDE PX-R, Nipa Inc., Wilmington, Delaware (about 100% active), tt) Glyceryl polymethacrylate and propylene glycol (LUBRAGEL DV) , Intemation Speciality Products, Wayne, New Jersey (about 46% live, except), uu) CARBOPOL ULTREZ 10 ( ULTREZ 10), cross-linked polyacrylic acid, BF Goodrich Specialty Chemicals, Cleveland, Ohio (about 98% active), w) Diisopropylamine, Air Products and Chemicals, Allentow n, Pennsylvania (about 100% active), ww) LAPONITE XLG (Astragalus sinensis, synthetic smectite), Southern Clay Products, Gonzales, Texas (about 99% active), xx) CELQUAT CS230M (Polyquatemium 10), National Starch and Chemical Company, Bridgewater, New Jersey (about 92% live, f), yy) polypropylene glycol-9 (PGG-9), Polyglycol P425, Dow Chemical Company, Midland, Michigan (about 100% active), zz) Ethanol (Denatured Ethyl Alcohol 40B), Gold Shield, Hayward, -48- This paper scale applies to China National Standard (CNS) A4 specification (210 x 297 mm) -------------- --- (Please read the note on the back to write this page) Order _ · 1284020 A7 B7 V. Description of invention ( 46

California, (approximately 〇〇% active), aaa) water - unless otherwise indicated, the water is distilled as follows via a CormngAG-3 water purifier - the deionized water (DI is prepared and tested using the following method) Examples. a) Determination of the rapid sterilization of antibacterial products. The activity of the substance is measured by the method of time-limited killing, and the activity of the slave is: the antimicrobial group under the antibacterial test composition, the challenged microorganisms = the function of measuring the exposed ash, which makes the small part Dilution composition and test bacteria:: Family: This test, medium: At temperature, contact for a specified period of time. At the time of coughing, the composition of the sputum is stopped, thereby suspending the antibacterial activity of the composition and reducing the percentage or logarithm of the test population. The general syllabus is familiar to those skilled in the art. D, the time-limited killing method is from. Any concentration test on the side. The choice of concentration used is for example and the concentration can be easily determined by a skilled artisan. :. The viscous sample is usually diluted at 5G%, rather than being viscous in the sterile 250 1〇〇^:' and the sample volume is added to sterile deionized water if necessary. All trials were performed in a triple trial, combining the results and reporting an average log reduction. The choice of root contact time period is also judged by the investigator. You can choose any contact time. The general contact time varies from 15 seconds to 5 minutes, of which 3 sec and ^ 4 are typical contact times. The contact temperature can also be any temperature, typically room temperature, or about 25 degrees Celsius. , 'bacterial heart floating liquid, or test inoculum, is in any suitable solid culture (please read the note on the back to write this page) installed • 1· i_i ϋ --II order----;· Ί· line. -49- I 1 I» 1 - Paper size scale (eNS) A4g^ 0 X 297 mm) 1284020 A7 B7 V. Inventive Note (47) (eg, agar) Prepared by growing a bacterial culture. The bacterial population was washed out of the agar with sterile physiological saline, and the population of the bacterial suspension was adjusted to about 108 colony forming units per ml (cfli/ml). The following table lists the bacterial cultures used in the following tests, including the name of the bacteria, the ATCC (American Type Culture Collection) identification number, and the microbial name dimples used hereinafter. Microbiological name ATCC# Abbreviation Staphylococcus aureus 6538 S. aureus Escherichia coli Escherichia coli 11229 E. coli Klebsiella pneumoniae 10031 K. pnenm. c/zo/eram/b cholera-salmonella 10708 S. choler. • Gram-positive bacteria, while £*· co//, AT., and X c/20/er. are Gram-negative bacteria. Place the beaker containing the test composition in a water bath (if a stable temperature is desired) or on a magnetic stirrer (if laboratory temperature is desired). The sample was inoculated with 1.0 ml of the test bacterial suspension. The inoculum is stirred with the test composition for a predetermined contact time. At the end of the contact time, 1.0 ml of the test composition/bacterial mixture was transferred to 9.0 ml of Tryptone-Histidine-Tween Neutralizer Solution (THT). A ten-fold dilution in the countable range is then performed. The dilution of different microorganisms can vary. In the triple test, the selected dilution -50 - the paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) --J-I--I---- II · II (please read first Note on the back of this page) Order: Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed 1284020 A7 Description of the invention (Thousands of plates cultured on TSA + culture plate (TSA+ contains (four) fat and polyethoxy & - 8〇" Trypticase Soy. Re-culture the plates for 25 ± 2 hours to count colonies to obtain the number of survivors' in the calculation of reduction percentage or log reduction. Control group count (number of control groups) is the experimental procedure as described above, but using τηί instead of the test composition In the standard microbiological method, the number of control groups and the plate count of the sample were converted to cfWmj. The log reduction was calculated by the following formula: l〇g1〇 (number of control groups)-l〇glQ ( The number of test samples survived) --------------- Install (please read the note on the back first to write this page) Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed the following table is the reduction of bacterial population Percentage and log reduction Reduction of logarithm % 90 1 99 2 99.9 3 99.99 4 99.999 5 b ) Preparation of TCS saturated aqueous solution: equipped with a 3 magnetic stir bar in a 4 liter flask and loaded with about 3.5 g (g) of TCS and 3 liters (L) of water. Place the 4 flask in a water bath, remove it, and heat (4 〇 _45. 〇) for at least 8 hours. From 51 - . The paper scale applies to the Chinese National Standard (CNS) A4 specification ( 210 X 297 mm) ---"-book----,---- 1284020 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed A7 B7 V. Invention description (49) Take out the water containing TCS/water The flask was suspended and the warm suspension was filtered through a Coors #32-H Buchner funnel equipped with Whatman #40 (5·5 cm) filter paper. The filter assembly was attached to a 2 liter vacuum filter bottle to The batch is filtered. The filtrate is transferred to another 4 liter flask and cooled. Generally, after storing the filtrate for several days at room temperature, fine needle-like TCS crystals are formed. For the killing experiment, the TCS solution was again filtered at room temperature before being used in the experiment. For other time-limited killing experiments, it leaves a small amount of TCS crystals in the test vessel to ensure saturation when the temperature changes. It is assumed that the TCS crystals present in the time-limited killing test vessel will not affect the test results, and should be crystal TCS does not act on bacteria (ie, it does not dissolve). To determine the concentration of TCS in aqueous solution, the filtered sample was analyzed by HPLC (in a triple test). The device used to filter the solution is Whatman AUTO VIAL® with 0.45 /zm PTFE membrane and glass microfiber prefilter, cat No. AV125UORG. The TCS concentration was calculated using a linear regression line match (Microsoft EXCEL® Software)' for the TCS/IPA standards included in the same HPLC assay. c) Preparation of TCS aqueous solution/surfactant composition: In a French square bottle, a solution containing various concentrations of surfactant and 0.3% by weight of TCS was added. The mixture was stirred and heated (35-40 ° C) for several hours until the TCS dissolved. The heating was carried out using a heating lamp controlled by a variable transformer, and the temperature of the solution was monitored with a digital temperature agent. Thereafter, the stirring was stopped, TCS seed crystals (about 1 mg) were added to the solution, and the mixture was placed at about 20 °C. After a few days, crystals can be observed at the bottom of the solution container, which has exceeded the TCS's most -52- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) -------- -------装--- (Please read the note on the back to write this page) II set · -- Line - 1284020 A7 B7 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing 5, invention description (5G) . Large solubility. The approximate concentration of surfactant required to dissolve the 0.3% TCS almost completely was determined by using an experimental design in which the concentration of the surfactant in a series of test samples was reduced by two, until the interface activity was observed. The approximate saturation point of TCS in the agent. The concentration difference (saturation pair just dissolved) was then halved until the end of the TCS saturation was determined. TCS/Interface The saturation point of the active agent composition can be effectively estimated for small scale (15 to 100 ml) samples, but requires approximately 600-800 g samples for reliable end results. Therefore, a small sample is used to establish the initial range, and the final concentration is determined on a larger sample. d) preparing a composition comprising a combination of TCS and a solvent or solvent/solubilizing agent: the TCS is first dissolved in a solvent used in the composition. Water was added to the TCS/solvent composition, about 1 mg of TCS seed crystals were added, and the resulting mixture was placed at about 20 ° C for crystallization. In a composition comprising a solvent, a solubilizing agent, and a surfactant, the TCS is dissolved in a solvent as described above, and a solubilizing agent and a surfactant are added to the TCS/solvent composition. Thereafter, the resulting mixture was diluted with water to the total volume of the batch. Adjust the pH as needed. The mixture was stirred at room temperature for about 1 hour, seed crystal TCS was added, and the mixture was allowed to stand still as above and crystallized. The TCS saturation point was also measured as described above (i.e., the surfactant concentration was halved). A method similar to the above determination of the maximum added concentration has been described in the literature. For example, PH Elworthy et al., "Solubilization by surface-active agents and its applicatin in chemistry and biological sciences," Chapman and Hall, Ltd., London, pp. 62-65 (1968) is described by observation Determine the concentration close to saturation by the turbidity of the mixture. Use -53- (please read this page on the back) 1ϋ ϋ fl·— I a — mmmf I .ϋ n ϋ« · This paper size applies China National Standard (CNS) A4 Specification (210 X 297 mm) 1284020 A7 __ B7 — V. Invention Description (51) High-intensity light generated by a small flashlight equipped with a beam focusing attachment, using a similar technique for observing samples at right angles (i.e., MINI MAGLITE® AA, MAG Instruments, Califormia, USA). This method was also used for solutions that are very close to saturation to enhance the observation of a small amount of crystals formed at the bottom of the vessel. Table 2 summarizes the The results of the time-limited killing test conducted by the TCS/water composition. The results of the two series, I and II, illustrate the effect of % saturation in the TCS/water compositions, ie, in a particular test series, % The reduction will also reduce the effectiveness of time-limited killing. (Please read the note on the back to write this page.) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Print 54 This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed A7 B7 V. Description of Invention (52) =: — 1 50% Saturated 100% Saturated 10% Saturated 50% Saturated 100% Saturated Sample 4.9x1 Ο*6 9/)xl〇-6 6.7x108 3.9xl〇-7 9.3xlO·7 TCS (g/ml) (by HPLC) 0.24 3.93 0.03/15S 0.03/I5S .. 1.07/15s 1 minute / or t S. aureus logarithm Decrease 0.02 >3.91 5 minutes 0.26 0.06/I5S 0.I3/15S 0.44/l5s 1 minute / or t E. coli 0.08 = >4.06 5 minutes 0.35 2.85 0/15s 0.21715s 0.32/I5s 1 minute / or t $ 2 3 ·〇二 2.76 >4.00 5 minutes 2.15 1 minute / or t S. chol. 5 minutes 嫂>2! Celluloid TCS/Yaga 吟蓥蛉 FM itch itching according to rice (please read the back note first) Write this page) - Armored one-mouth, ·. This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 _ __B7_;__ V. INSTRUCTIONS (53) The data in Tables 2 and 3 show that when the TCS concentration is extremely low (ie, 5 to 10 ppm), the effect of time-limited killing is higher than that of 1 The sample of ^^ is low. For example, the sample of Table 2 containing 0.93 ppm TCS has a logarithmic reduction of 0.44 against E. coli after 15 seconds, while the sample of Table 3 containing 484 !) pm TCS has a logarithmic reduction of 4.13 against the same microorganism after 15 seconds. . This effect is more pronounced during shorter contact periods. Another example in a more complex composition is described in the sample in Table 3, ie 50 ppm TCS (estimated) / 10% PG / 5% SXS pair (448 ppm TCS (estimated) / 20% PG / 10%) SXS). Samples with higher TCS concentrations showed a bacterial reduction of at least 1 log higher after 1 minute. The data in Table 3 also shows the difference in efficacy between different solvents/solubilizers used at approximately the same TCS concentration. (Please read the note on the back first ^^|$write this page) Ministry of Economic Affairs Intellectual Property Bureau employees consumption cooperatives print 56 paper scale applicable to China National Standard (CNS) A4 specifications (210 X 297 mm) 1284020 A7 B7 Five , invention description (Ministry of Economy, Intellectual Property Bureau, employee consumption cooperative printing 〇 ON V-ϋ ο ο 1385 oc VC 603 723 510 484 n3 11 () (estimated) o 112 (estimated) (ppm) TCS Table 3 - Solvent and / or TCS in the solubilizer system 5% SXS 5% SXS 75.00% PG 50.00% PG 50.00% PG 47.52% PG 45.05% PG 44.20% PG 42.53% PG 41.86% PG 40.01% PG 23.85% PG 17% IPA I7% IPA Solvent / solubilizer 1.20/15 0.15/15 >4.49/15 >5.17/30 >4.69/15 >3.46/15 >5.17/30 >3.46/15 4.79丨)/302) S. auerus 0.33 >4.43 2.35 0.13 >4.49 >5.17 >4.69 >3.46 >5.17 >3.46 >5.17 >4.39 0.42 >4.42 1 cent £ 0.35/15 0.25/15 4.45/15 4.42/30 4.21/ 15 >4.38/15 4.47/30 4.13/15 4.29/30 E. coli -0.15 0.96 0.26 >4.65 >4.67 >4.65 >4.38 >4.67 >4.38 >4.67 2.37 -0.24 >3.56 1 Minutes--I-------------Ί (please first Read the note on the back page. · 57 « 公 97 2 X 10 2 y^\ 格 4 4 4 4 4 4 Illustrated by the Ministry of Economic Affairs, Intellectual Property Office, Employees' Consumption Cooperatives, 〇LA s ο 1 Ο ^-Λ 4·“ —τ- ο ΟΟ Ό ο I Η η 0Q > 1 \ W iB 家~U Η η CO 〇〇 〇CO X 00 二α -σ Ο ο CO XC/D ο -α Ο D; CO η 00 Ξ -ο Ο D; 00 Ω S CO X CO Ξ S 00 X 00 -D Ο 00 X 00 NJ Ο i 00 X GO in 〇η Ω 〇δ ψίτ a\ 〇S UJ 〇V UJ •ΟΝ UJ OJ Ο ο ο V -fc. 二& Ο 2 p 〇V LO ΟΝ ο S ο ν〇ο S LO 丄NJ ο V s s UJ 2 〇ΓΟ σ\ V All UJ Ο • to UJ 〇Γ5 〇V ο Ό CN •Ό Ο ο LO LO OC ·: V ό ο g 5β (Please read the note on the back first - write this page The paper size applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7

Ministry of Economic Affairs Intellectual Property Office staff

〇 ON UJ o Two oo g LO UJ I ro 1 4»U O a-U UJ a· Everyday Η on CO La cn CO | I. Ss 1 aa NJ o La £ § o 6 0\ Ui O 2 o 1 ro UJ a 2 fs £ $5V 逢 \ 〇〇s Ui is-) Cn KJ\ •ro ON o hO s 1 UJ to u> o 1 UJ •CN Cs - k> vC P. bo v〇V g 1 ro ON v〇to SJ iv〇三·: 〇\ oi ro La ro LO s Ό c: LO \ NJ Ni UJ UJ ·: UJ ί vC (Please read the note on the back first - II · n I Ί I i J - I 5 5J · write this page) 1284020 A7 B7 V. Invention Description (Θ) a) 牦 牦 :: Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative Printed 〇S i ο 1 «»w ο 4«U ° oc i α·“ I (一) η 00 Ό 〇i CO X in Ξ La σ Ο ο 00 X 00 5 G 03 Q ο ο ίΠ η GO 5 00 X CO 5 w CO X .CO § 0 1 CO X 03 K> o -a 〇o CO X GO 00 La 00 Q 窆\ 〇ο V ο o NJ K) Cj o LO NJ UJ o -3⁄4 § ο. LO ν 〇V Ξ o L〇V 到to Ο UJ CN UJ ο V Ξ & ο o to o UJ uj o ?〇ο 1 •ο VV UJ •CN oo -60- ----------- ---Install---(Please read the note on the back first to write this page). This paper scale applies to China National Standard (CNS) A4 specification (210 χ 297 mm) 1284020 A7 _ __B7_:___ V. Description of the Invention (%) Many of the compositions of the present invention contain a surfactant which potentially reduces the efficacy of the antimicrobial agent. The following examples show the accidents achieved by the compositions of the present invention. Example 1 In this example, a composition of the invention was compared to three commercially available antimicrobial cleaning compositions in a time-limited killing test using a contact time of 5 minutes. (Product A) is a saturated solution containing 0.3% triclosan in 1.5% aqueous sodium cinnamate (SLS) solution. These three commercially available antibacterial cleaning compositions with unknown triclosan concentrations Department of Jergens Antibacterial (JA) Hand Soap, Andrew Jergens Inc.; Clean and Smooth (CS), Benckiser products; and Soft Soap (SSp), Colgate Palmolive products (please read the note on the back) ) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 6 paper scales applicable to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (59, ): Shu: ax ilMiJi game bowl Jun; 2) dnk: = ^ s > ^: iL]): f% Wheat private shopping TCS >: 4 / &. plurality 7MSDt ~ ^^ π, νΛ. A JA CS SS1) Β 0. 3 1. unk. Unk. (Please read the note on the back first%) ^ 100 ullk· ullk. cllk. Write this page) Install S. aureus V4.47 2.4100 N80 1.62 E . coli 〉4·41 0 20 0.00 000

l·___III 1 II 0.20 Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed K. pneum. 〉 436 01100 0.10 s. Choi. 么.67 62- This paper scale applies to China National Standard (CNS) A4 specification (210 χ 297 gong) PCT) 1284020 A7 B7 V. INSTRUCTIONS (6G) 'Examples show that the composition of the present invention provides an unexpected second solid in comparison with the currently available product in the logarithmic reduction of the bacterial population, and this is contained in the SLS. When the water-repellent composition of the three gas is saturated in the surface, the two products are available in three trials, such as children, and have a significantly higher antibacterial efficacy, such as Gram-positive and Gram-negative microorganisms, both of which are: Health threats. ^ EXAMPLE 2 This example shows that the antibacterial activity of the compositions of the present invention is made up of active antibacterial agents rather than surfactants. The test composition and A_2 were prepared. Composition Ad is a solution containing 0.3% diclosan, i 35% ammonium lauryl sulfate, and equilibrated with water. Composition A-lanthanide was saturated with 100% triclosan. Composition A-2 is a "soothing d", i.e., an aqueous solution of 1.35% ammonium decyl sulfate, which does not contain an active antibacterial agent. 11 — J111 11111 ^ --- (Please read the note on the back first to write this page) · . Ministry of Economic Affairs, Intellectual Property Bureau, Staff and Consumer Cooperatives Printed 63- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed A7 _B7 V. Invention Description (61 > ΓΟ > 〇〇: 〇w 〇〇VV •ON y: 2 Γ5 ξ Λ· 〇L/i Ο 〇V Male Uj VO $ 2 1 〇〇LO y: -64- (Please read the back Note the matter on this page) - The size of the paper is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1284〇2〇5, invention description (The Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed the invention Composition A-丨 clearly provides an excellent, wide range of antimicrobial activity while placebo" Composition A-2 has only a very limited range of activity. Composition A-2 has a particularly poor efficacy against Gram-negative microorganisms. The control system of Gram-negative microorganisms is particularly important, so that micro-cause can cause significant health threats. The antibacterial activity of the composition is excellent in a wide range of antibacterial activity, and the antibacterial activity is undoubtedly in the continuous aqueous phase. In the present example, it uses a solvent (i.e., propylene glycol (PG)) to dissolve triclosan in an aqueous carrier. There is no solubilizer or surfactant present. Composition A-3 Containing 0.0872% by weight of tri-aerobic, 475% PG aqueous solution, and equilibrated with water. Composition A-3 is 100% triclosan saturated and is a composition of the present invention. Test composition A-4 is " "Placebo" consists of 47.5% by weight of 〇 and is equilibrated with water. & An example illustrates the additional advantage of including a selective hydroxyl-dropping agent in the composition. In particular, it was observed in the previous example at 1 and The excellent range of activity exhibited by the $min contact time can be achieved in the case of hydroxy solvent 2 with a contact time of 30 seconds. This example further illustrates that the composition of the present invention < antibacterial activity is undoubtedly the presence of an antibacterial agent Caused by: IIJII I----- II --- (Please read the note on the back to write this page) · -65- 1284020 A7 B7 63 V. Invention description () . This paper scale applies to Chinese national standards (CNS ) A4 size (210 X 297 mm) 1284020 A7 B7 V. DESCRIPTION OF THE INVENTION (64) Example 4 This example demonstrates that the compositions of the present invention provide acceptable disinfecting efficacy despite the relatively low concentration of disinfecting alcohol. Examples B-1, B-3, and B-5 contain 0.15% by weight of triclosan, 100% saturated. Examples B-2, B-4, and B-6 are comparative examples containing 0% triclosan. (Please read the note on the back first to write this page) Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing -67- This paper scale applies China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 5 5 Ministry of Economic Affairs Intellectual Property Bureau Employees Consumption Cooperative Printed l· 奈 na · C η d rn N ο 3 小Ο 1 SM W 〇〇〇•S ο UJ 1 1 U) OQ Ο σ 1 ΓΖιΓ ν^γ rr · 〇〇〇ο • UJ 1 1 LO 〇〇•ο ο ο 03 ro 〇〇〇S Ο Uj OO fO οο '〇ο Seven C3 P 〇〇ο οο •ο ο ο CD •k 〇〇〇S ο •UJ ο b I 1 ο 二σ ·〇〇〇ο Uj XX ο •Ο 1 1 ο ο ψ σ\ --------------^---(Please read the notes on the back first Write this page) Order ·- 68 The paper size is applicable to China National Standard (CNS) A4 specification (210 297 297 mm) l284〇2〇A7 V. Invention description (66 The following table summarizes the results of the 15 second limit killing

(Please read the note on the back to write this page.) Printed by the Ministry of Economic Affairs, Intellectual Property Bureau, Staff Cooperatives, etc. These results show that acceptable disinfection A is achieved, even in disinfectant alcohols and other polyhydric solvents with age content. At the same time, the composition of the present invention can be provided because of the non-volatile nature of the active ingredient triclosan: continued, antibacterial effect' while the currently available compositions do not provide sustained antibacterial activity. Specifically, 'Examples B-3 to 6' indicate that the rapid antibacterial activity of the composition of the present invention is mainly caused by an antibacterial agent (e.g., triclosan) rather than a disinfecting alcohol. This is contrary to the disclosure of the prior art. For example, the composition β_3 contains only 28% ethanol, but it has excellent antibacterial activity against Staphylococcus aureus and Escherichia coli. The teachings of the prior art rely on high alcohol concentrations (i.e., > 40%) to achieve a rapid, wide range of antimicrobial activity. Example 5 69- The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) !284〇2〇Α7 Β7 5. Inventive Note (67 This example shows the species of surfactant 31⁄2 i . , ^ The effect of hard on the antibacterial activity of the composition. It is described in the following test society. Wu De 7 You are using a variety of different compositions, which contain anionic surfactants or representative cations, dangerous ions, bisexual, And non-ionic surfactants ^ This example group 4 saturation percentage is at least about 90%. ---- -------- - Install i I (please read the note on the back first to write this page) Order:

Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed -70- This paper scale applies China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (68 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative print system

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\ S' \ \ 试巻•7^ 楽Γ hi 〇Η ο L〇ί η GO 〇U> 3 Q 〇UJ Q 〇•UJ Η 〇Uj η in ο •Ui 〇U> 〇Η LO•LO ί • UJ § η CO 〇f〇多b SI ΰ ο 土ϊ一丄1 l·荈一C0 ; 0 ^ ISJ 〇κ> 00 一〇S ft 4 S ^ w爿. and W although 00 io Q ^ ο ^ NJ — 2 cn h 5 black w漭ί κ ο ^ §7 ? i η a s “ r ^ U δ·系 l· 沴Eg 9 η -&.— ^ 〇jaV 苎l· P l· — &gt ; -fwl· C^ a fat > Φ ο 十〇ο + ΐ + main τ .1 Ο y 〇 cold 2 ^ ζ ο 〇〇〇〇ο O ο ο 二内今 S 72 ------ ---------Install --- (Please read the note on the back first to write this page)

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++ί. >3.99 ί-Γ>2.99 土- >1.99 - V0.99 0 〈SVC .桊\ .乐〇Lj η 00 〇Uj ί 〇Lj S go o^ ν〇s卜〇^ 一荈Id bo Prepare U4 Σ> 漭l· ♦ 〇十Ο沁兮i yS?S Ο 〇〇 Today S (please read the note on the back first) Page -tr°J. -This paper scale applies to Chinese national standards (CNS) A4 size (210 X 297 mm) 1284020

71 V. INSTRUCTIONS INSTRUCTIONS (The Ministry of Economic Affairs, Intellectual Property Office, Staff Consumers Co., Ltd., printed on the results of the above description, unexpectedly, when the percentage of saturation of the antibacterial agent in the composition is south, that is, at least 5%, antibacterial The agent and the anionic surfactant form an effective antibacterial composition. In addition, it has also been observed that in the homologous series of surfactants, the efficacy may be different (i.e., in the homologous series of the alkyl 4-acid) , sodium dodecyl decanoate and sodium octyl sulfate can produce highly effective formulations. The effect of cations is also quite unpredictable (ie, sodium, ammonium, and triethanolammonium dodecyl sulfate provide efficient blending) And the effect of the surfactant type on the antibacterial activity of the composition. The following is an example of the data provided in Example 5. The table includes various combinations. 7Into the results of the test, the compositions contain anionic surfactants or representative examples, including cationic +, anionic / nonionic, amphoteric, and nonionic surfactants. 'A variety of anionic surfactants can form a highly 疋 system. High activity (ie, simultaneous high log reduction for both Gram-positive (G. aureus) and Gram-negative (E. coli) bacteria Related surfactants include sodium lauryl sulfate, sodium octyl sulfate, sodium 2-ethylhexyl sulfate, and oxidized dodecylamine. However, the high activity of the composition containing oxidized dodecylamine may also be ^ j牝Your king wants to be caused by the surfactant of the child. Series 0 I (dodecyl sulfate) indicates the effect of sputum caused by J Tianzheng. Sodium dodecyl sulfate has the highest efficacy. ', early ethanol ammonium, and triethanolammonium have low efficacy. Because ten-to-A A-one from the base thiopurine potassium at room temperature, low solubility -74-i sheet scale is applicable _ home standard (CNS) A4 specifications (10) X 297 gong f (please read the note on the back to write this page) Binding·· -7. Line - 1284020 A7 _ __ B7 ' ---------:------ V. Description of invention (72) The degree of resolution has not been tested. Series I (dodecyl sulfate) and series η (other alkanes A comparison of the hoofs shows that the homologous series (ie, n-alkyl sodium sulfate) have different effects. Sodium dodecyl sulfate and sodium octyl sulfate can produce high-efficiency copper ligands, and branches The surfactant 2-ethylhexyl sulfate is also the same. The series III (mercaptocarboxylate) suggests that the TCS/carboxylate composition is not highly active against the Gram-negative bacteria, but against the Gram-positive bacteria. It has acceptable activity. Series IV (tantalum-containing surfactant) confirms that ethylene oxide (ΕΟ) in the surfactant tends to inactivate TCS. SLES-1 and SLES_2 against Staphylococcus aureus The active system is thus caused by an anion of an anionic/nonionic surfactant ("dot-dodecyl sulfate"). The results for Series V (other various surfactants) show that these compositions have moderate to low activity, with the exception of oxidized dodecylamine. The highly active portion of LA is caused by the surfactant alone due to its cationic nature. The remainder of the series v surfactant/TCS compositions showed different activities against Staphylococcus aureus (Glan's positive) and very little activity against E. coli (German's negative). (Please read the note on the back first - write this page) Ί线. Printed by the Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative

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73 /V Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 眷 5^ % % % τ Cai δ JS\ *^β 1 •2 5 | 2 1 00 •S _ 00 1 d SS s 2 1 QSSQ 2 1 CO 2 Q _ Q 2 1 ? •s 5 ·: S ro to 1 to ο" Sd ν〇lyi to m VC NJ and ο "55 K) § Ky\ >52 1/» ί | lyi ί ? he S Kj\ Ο System 漭W UJ % % > 5 u» i 彩 1 U) LA 游 1 ON 彝w Os Ϊ 彩 S i NJ S NJ SU) •NJ ! •UJ Ο έ ν〇έ Ό UJ -3⁄4 έ I 5 2 έ Ό ί \〇• i Γ° UJ ui NJ ivj v〇's - v〇! i〇- jo υί> i〇- is \ 〇二ο LU is one;? ^ S 1 ! VC Μ UJ \ 1 VV \ SSS \j\ 1 QS 〇〇s CO ij ί ·: VC Cj g NJ % as i CTs § mrnmt V w (please read the note on the back) Page) ------I - 76 2 1284020 A7 B7 V. Invention Description (Printed by the Consumers' Cooperative of the Intellectual Property Office of the Ministry of Economic Affairs

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5 6 5^ 卜· Η η 00 % Zj ^ Ο Ώ a g cold SW € S (please read the note on the back first) ---^--^---Γ — order----i ---- -77- The paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (Yes) Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing details - \ ΤΪ3 — — Taste < 1 1 Umbrella TSS Ten & Η 〇 η in ο UJ 2 ri 00 o H 00 Η Ρ Π u> 00 g 〇Uj on \^J Ά •OJ o 0Q ο L〇2 d ο U) δ ο UJ 2 don 00 o Uj Q ^ % NJ Ο Di il a -δ 桊Ο1 Ίγ □g > S η > Eg 9 η 公一〇κ 苎l· l· z ft is O NJ 〇- € s ΓΠ — A 拉Ο L〇l· Μ Σ> 涔l· 00 〇C: 1 1 卜* 5· l· 00 r 00 ο :3 \ 1 l· 济 s Ίλ Sk Ώ3 ec: 京 p\ ί漭> o C; > 〇ρ ο ο ·: <b ο v〇s ρ ό s NJ 一〇ZV 2 % 2 LO ν〇u> oo UJ '5 b\ 0C ro VC LO ·§ -u O % Ui Cj V ro \/ •NJ Ο ^ ^ i ~ ^ Today S ο ο IS 0 to 1 p ό 3: P 〇〇δ Μ LO O •ro oo δ LO LO 〇O f〇p s ό s 〇LO ON δ Ui oo C5 s δ Ξ; A •i > O Xx i: V y ON LO V s CS LO Cs -78- --------------- Pack--- (Please read the note on the back to write this page) 1 5J. This paper scale applies to China National Standard (CNS) A4 specification (210 297 297 mm) 1284020 A7 B7 V. Invention Description (76) Example 7 This example illustrates the effect of TCSi% saturation in a surfactant composition (i.e., a composition that does not contain a hydroxy solvent and a solubilizing agent). The data summarized in the table below illustrates the effect of TCSi % saturation on TCS efficacy in TCS/surfactant/water compositions. Two parts of the table (i.e., the TCS/ALS composition against E. coli and the TCS/SOS composition against Staphylococcus aureus) showed a significant reduction in antibacterial activity as % saturation decreased. At the same time, 100% saturated samples (0.15% TCS/0.67% ALS) and (0.15% TCS/4.0% SOS) have antibacterial activity close to 100% saturated samples containing 0.3% TCS. In these two examples, these effects are clearly visible on microbes where the surfactant does not exhibit a strong placebo killing effect. (Please read the note on the back first to write this page) Printed by the Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative-79- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (77

Tns%/%#> S0/100 0.27/90 0.21/70 0.15/50 0.15/100 0/0 0.30/100 0 27/90 021/70 0.15/50 0.15/100 0/0 0.30/100 0.27/90 0.21/70 0.1 0.15/100 4oo%sos 5.751 5.75% sos

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U0/3.S 0.09/1.17 0.37/1.54 0.61/2.89 1.39/3.95 E. coli (30S/1 Cold Daddy Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed>4.44/&gt;4.44 V444/V4.44 &gt;4.44 /v4.44 〉4.44/&gt;4.44 〉4.i/3.98 -80- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) K. Imeum. (30S/1 寒恭) 1284020 A7 B7 V. Invention Description (7δ) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed clothing ri 〇δ € 00 〇00 % Every s Mai i Co 〇i fO UJ 〇CO 2 s Today B Daddy $ 卜 » — ο S. Dad · Vt V ο ^ %, and Vs • What-----------------^--(Please read the note on the back first to write this page) --^ 1 订--------- -81 - This paper size applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 79 This five, invention description (Example 8) This example says the sun and the moon It can be used as a hand cleaner - an example of the step-by-step description - a specific example of the invention, 1 in the second two: There are 3% by weight of triclosan, 〇 5% Ammonium dodecyl sulfate, 2% propylene glycol, and 10% sodium xylene sulfonate, and equilibrated with water. Α-6 contains 0.1% by weight of tris, 〇 125% xylene Ammonium sulfonate, 20% propylene glycol, and 10% sodium xylene sulfonate, and equilibrated with water. Compositions Α-5 and Α6 are 100% dichlorosodium saturated. Composition α_7 is a "placebo" It contains 0.5% by weight of ammonium lauryl sulfate, 2% by weight of propylene glycol, and 1% by weight of sodium xylene xylate, and is equilibrated with water. 1 JI---i- (please read the back first) The note is written on this page. ·. Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed -82- ^ Paper scale applies China National Standard (CNS) A4 specification (210 X 297 public) 1284020 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative Print A7 __B7 80 V. Invention description () &gt;&gt; 6s &gt; λΙλ 〇 bp 〇1“ 2 〇o : o UJ k) NJ - •s V *2 y: 3 5 S LO 卜·粦OJ Lo ON VV 'What $ go LO bo to UJ La 5 UJ •Ό •to CN i&gt;5 ----------------- (Please read the note on the back first to write this page ) I - the paper size is suitable China National Standard (CNS) A4 size (210 X 297 mm) 1284020 Α7 Β7 V. invention is described in (81 this Example illustrates two important features of the present invention. First, the absolute content of triclosan, or other antibacterials, is less important than the percentage of saturation of the antibacterial agent in the composition. For example, composition A_6 (containing 1% triclosan) is at least as effective as composition A_5 (containing 0.3% triclosan). An important feature is that both compositions are triclosan saturated. Second, Example 5 also clearly shows that active antimicrobial agents are responsible for the excellent range of broad antimicrobial activity. The compositions A_5 and A_6 of the present invention are significantly better than the "placebo" composition A-7 which does not contain an active antibacterial agent. EXAMPLE 9 This example illustrates that a hydroxy solvent and a solubilizing agent can render surfactants and antimicrobial compositions that are otherwise inactive in other situations active. In the table below, all percentages are by weight and all compositions are water balanced. Composition B contained 1.35% ammonium dodecyl sulfate (ALS) and 0.3% triclosan (TCS). Composition C contained 1.35% ALS and 0.0% TCS. Composition D contained 0.25% ALS, 14.4% DPG, 10.0% SXS, and 0.3% TCS, and Composition E contained 0.25% ALS, 14.4% DPG, 10.0% SXS, and 0. 0% TCS. Compound F contained 2.5% alkyl polyglucose (APGTM) and 0.3% TCS. Compound G contained 0.3% APG, 14.4% dipropylene glycol (DPG), 10% sodium xylene sulfonate (SXS), and 0.3% TCS. The compound Η contains 0.3% APG, 14.4% DPG, 10% SXS, and 0.0% TCS. Composition I contained 1.25% sodium cocoamphoacetate (SCA) and 0.3% TCS. Composition J contained 0.25% SCA, 14.4% DPG, 10.0% SXS, and 0.3% TCS. Composition K contained 0.25% SCA, 14.4% DPG, 10.0% SXS, and 0.0% TCS. Composition L contained 1.75% cocoamidipropyl triammonium lactone (CAPB) and 0.3% TCS. Composition Μ contains 0.25% CAPB, -84- This paper size is applicable to China National Standard (CNS) A4 specification (210 X 297 mm) (please read the note on the back to write this page) Ministry of Economic Affairs Intellectual Property Bureau Employees Consumption Cooperative Printed 1284020 A7 — __B7___ V. Description of invention (δ2) 14.4% DPG, 10.0% SXS, and .0.3% TCS. Composition N contained 0.25% CAPB, 14.4% DPG, 10.0% SXS, and 0. 0% TCS. Composition 0 contained 4% of octoxynol_9 (TRITON Χ-100ΤΜ, ΤΧ100). The composition Ρ contains 0.75% ΤΧ100, 14.4% DPG, 10.0% SXS, and 0.3% TCS. Composition Q contained 1.25% sodium lauryl ether sulfate (1 EO, SLES-1) and 0.3% TCS. Composition R contained 0.25% SLES-Bu 14.4% DPG, 10.0% SXS, and 0.3% TCS. • 1 1 IU ϋ ϋ 1 n I ϋ I n I · ϋ ·ϋ n II 1_1 · ϋ a— ·ϋ Ί — ι ·ϋ - (Please read the note on the back first to write this page) Ministry of Economic Affairs Intellectual Property Office staff Consumer Cooperatives Printed 5 8 Paper Scales Applicable to China National Standard (CNS) A4 Specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (S3, Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed a C TJ ΓΏ σ n CO 〇'〇2 ο •LO ο S UJ •o 〇•LO •O 〇Uj l·, 〇•NJ GO η &gt; • σ ρ 〇00 X 00 ο NJ on 〇&gt; • σ ρ ο ο 00 X 00 Μ 00 η &gt; ο Lj &gt; -ο ρ • 二•σ &quot;0 ρ •ο CO X GO ο •UJ S -d ρ αα Π3 ρ ο ο CO K) &gt; o 〇to &gt; Ξ 〇p 5 〇GO &gt;&lt; CO o *NJ &gt; • What a υ po § CO □ &gt; ·: L/i &gt; Pull. 〇丄ο 丄ο Ο 上 ο 丄o on o 厶ο o 丄〇ν〇〇&quot;〇〇σ\ 〇be oc V UJ VC Uj VO ρ &lt;b 3 SV as ν〇CN ν〇VO •LO '— ·: V LO g LO •g V LO v 〇V UJ VC V UJ v〇岑VO Ό i&gt;3 c§ 玄 i ro Ό Ο *s V ό ρ V ν〇Ο LLn .〇La OC V bv VC V Sx bv v〇V ro •2 vC V* public oo V •UJ OO UUj oc ό •i CD •LO V〇UJ •v〇§ s ----.-----------(Please read the note on the back to write this page) ·- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. INSTRUCTIONS (84 Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed 7〇Ο -3 Ο 2 X 广 • e 〇 • UJ Ο S ο 二 .〇Ui o U&gt; W • ^ 〇N) 00 r cn CO 1 Ξ σ -α ρ ρ ο GO X 00 CO rm CO 1 XX ο •Ξ α ρ 5 ο 00 X 00 What X '〇ο *fO n &gt; *·Ό CD • What ap •oo GO X! 00 o io n &gt; -a C3 σ &quot;T3 po 00 X 0Q n &gt;&quot;O Cd ο 上上上上 丄ο lo 〇上o ν〇•NJ V •ΟΝ ο -CX •ΟΝ ν 〇Ό Lj s V UJ g LO V UJ v〇% UJ VC V UJ UJ O a ^ i Xuan 1 _ _ %, ten % brother V α\ % CNCN Ό 〇〇 〇〇V •ΟΝ V* 么ΟΝ ν〇 90 V 'lo oc LO OC ό o 6 go Ui VC UJ Ό C/3 ~· 87 . This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 )) ---1----------装---^--^(Please read the note on the back first to write this page) ϋ an one, ϋ ·ϋ Ί§ I βϋ - 1284020 A7 V. INSTRUCTIONS INSTRUCTIONS (The results of the time-limited killing test described above are very unexpected. The use of (iv) agents and solubilizers allows the use of only low to medium efficacy surfactant/TCS combinations to produce south antibacterial activity ( That is, the composition F is compared to G; I versus J 'L versus Μ ' and Q versus R < efficacy). The solvent and solubilizing agent can also result in a higher activity of the active composition in a shorter contact time (i.e., comparing the component Β to D). In particular, it has been observed that hydrazine solvents and solubilizers can even produce compositions against non-ionic surfactants (ie, 〇-〇1-9) against E. coli (comparative composition 〇 p) . This result is due to the fact that the phenolic antibacterial agent is inactivated by the surfactants known to be multi-ethylene, π &gt; w heart, and 虱 虱. Example 10 This example illustrates the importance of % saturation in a group of people containing hydroxy solvents and solubilizers. As observed in the surfactant/TCS composition; the relative % saturation of the microbial agent in the aqueous phase of the composition is also substantial: the antibacterial activity of the composition of the plastic, antisolvent and solubilizing agent. For example, the topping θ contains hydroxy _, and the lower cf 士要# shows that the effect on the antibacterial activity is particularly obvious in the case of the gram-negative bacterium. - Around the pneumonia Cray - --- (Please read the note on the back to write this page) 1 ^ 1 line! Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed-88- Table Paper Scale Applicable to China National Standard (CNS) A4 Specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (S6) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumption Cooperative Print N ·&lt; X &lt; C Η ζΛ P b 〇UJ 〇UJ 〇•UJ 〇〇s 2 2 ·〇〇goo ο ο ro &gt; 2 § § &gt;&gt;&gt;&gt;&gt;&gt;&gt; NJ La Κ) to s: •ξ 〇α σ La o 〇o α • σσ P 〇〇pss *Τ3 ρ ·〇ρ 5 ·〇〇〇ρ ·〇〇O 5 ο ο ο C/D 00 〇r^so 京O ο X OQ X 00 Pan X m 00 X 00 00 00 X CO .cn X 00 〇Λ X Λ l mmm o ώ Η (λ ι •Μ» -89 - (Please read the back of the note first) Write this page) i binding ·- . This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed A7 __B7 V. Invention Description (87)

N -&lt; X &lt; CH OQ AX 1 1 1 1 1 1 1 1 os VC 3 δ LO V LO • On NJ • CN fO VU) bs NJ LO • ON ro If 1 1 1 1 * With 1 1 LO | NJ iSr U Ό 乂l/» Ό \7 •EX v〇乂VO V* VO V Ό \7 么 v〇!§: 1 t 1 ,1 • 1 » 1 〇•to 〇〇s 〇'〇〇 Ό U) (〇*Cn v〇NJ LO %&lt;X *5 σ\ S 11 bo Ο to to *u&gt; UJ •NJ NJ OC UJ UJ •VC v〇UJ VC ro V* LO *0C Ln o V LO OC ln V UJ bo \7 LO OC V-Tl V UJ OC n7 LO OC II -90- --------------- Packing - (Please read the note on the back first) On this page) · This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) l284〇2〇5, invention description (B7 88 Ministry of Economic Affairs Intellectual Property Bureau ^ ^ number, it is obvious that the increase of antibacterial activity (It is measured by the time limit reduction test) and the antibacterial agent is depleted in the special time 1 - the actual (four) -, and the water phase / ° saturation < increase the example is not, in the maintenance of active antibacterial agent High % saturated # : The system contains:: bacteria agent 'surfactant such as ^ tMdi this - example, synergistic example 10, indicating that it seems to be saturated in a few solvents: 炅The role of the oxime solvent, and the composition of the surfactant. As observed in the early surfactant/TCS composition, the antimicrobial agent is in the composition; and the relative saturation also affects the inclusion of several solvents and/or additions. The activity of the composition of the tableting agent: from the data summarized in the table of Example 10 and the table below, it is apparent that the activity of the agent is significantly increased (as measured by the time-limited killing test) and the antibacterial agent. The increase in % saturation is associated with a particular type of composition. This is illustrated by two different aspects. The appearance of Example 1 shows that the concentration of surfactant is varied while maintaining the composition of the other components. The following table shows that in the table of the example of the effect of changing the concentration of all other components, the effect of changing the concentration of TCS 4, the relative saturation of the data on % saturation is difficult to calculate directly because of % saturation. Even with this kind of footing data, the effect of Test % saturation can be clearly seen from all the test organisms in the two tables. rt-4---------- loaded (please read the note on the back first)豸^-^^豸this page y

• nn I -----订-· . . . · Consumer Co-operative Printing -91 This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Description of invention (89) 0.103 0.166 0.207 0.248 P300 0.330 P372 o.±3 wfllt % 5%DPG,

5% DPP

5% DPP

5% DPP

5% DPP

5% DPP

5% DPP

5% DPP (please read the notes on the back first)

5% SXS, 0.75% ALS

5% sxsro.75% ALS

5% sxso.75% ALS

5% SXS

0.75%&gt;LS

5% SXS 0.75% Ars

5% SXS 0.75% Ars 5% SXS, 0.75% Ars

5% SXS, 0.75% ALS and multi-Λ/ν 25 50 60 73 80 90 i % &lt;? 1.72/1.93 1.94/2.15 1.96/3.05 302/4.05 〉4.55/&gt;4.55 〉4.55/&gt;4.55 V4.55 /V4.55 V4.55/V4.55 •s*. ires (30S/60S)

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This - examples illustrate different levels of _ agents and solubilization (four) in the antibacterial effect 々 =. In particular, the number of the following table is summarized in the following table: (4) solvent (four) / relative content of the sword &lt; role. It should be noted that the addition of flavor (pF) and/or vestibule 4 (DMDM) to the composition has only a minor effect on the antimicrobial efficacy of the composition, if any. ---^---------- Install i. (Please read the note on the back first to write this page} Customize the Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing -93- This paper scale applies to China Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 91 V. Invention description () Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing

-94- (Please read the note on the back first---write this page) · This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention description (92) Ministry of Economic Affairs, Intellectual Property Bureau, employee consumption cooperative, printing

-95 - (Please read the note on the back to write this page) -Installation n I-1, fl 11 IV ^IBi in an · -\-口' This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed A7 _B7 V. Invention description (93) 96 CD σ &gt;&gt;&gt; 吟ο *〇ο |π ^ Ρ &gt; • αα ο &gt ; α •α α rs ρ ο 00 X 00 % Zj ^ 11 Vr B ο ro 〇〇ρ NJ οο V Ό La ν〇〇^ m ^ S g ^ CN . Gl i沁g.- •-----------------(Please read the note on the back to write this page) -Γ . This paper scale applies to China National Standard (CNS) A4 Specifications (210 χ 297 mm) 1284020 Ministry of Economic Affairs, Intellectual Property Bureau, Staff Consumer Cooperative, Printed A7 V. Invention Description (Antibacterial against Staphylococcus aureus and Klebsiella pneumoniae observed in composition S, T, U) The activity will increase in particular with a decrease in the W surfactant (i.e., an increase in the saturation of the butyl group). The compositions cc, HH, MM, and RR show that in compositions containing a hydroxy solvent and a solubilizing agent, 15= or more of the SXS system is preferred to produce the same activity against Klebsiella pneumoniae. This observation result suggests that the solubilizing agent may be used as an adjuvant due to significant antibacterial killing (ie, at least The logarithmic reduction of 2) can be reduced by the time required. Example 13 The data summarized in the table below supports a theory that two major factors that improve antimicrobial efficacy are relative to surfactants, hydroxyl solvents, and antimicrobials. , the group, the surfactant and the solubilizer of the antibacterial agent content The surfactant containing a percentage relative to I can reduce % saturation and thus reduce the antimicrobial activity of the composition. On the other hand, a higher percentage of solubilizer appears to provide higher activity against some microorganisms, b, pneumonia Salmonella typhimurium and Salmonella cholerae. It is therefore inferred that a higher percentage of solubilizer in the composition provides a greater amount of active antimicrobial agent in the water (i.e., non-microcapsule) phase of the composition, thus providing The higher limit is to reduce the activity. Therefore, the solvent can be used as an additive to enhance the antibacterial activity and provide more physical stability in the composition. -97- The paper scale is applicable to the Chinese National Standard (CNS) A4 specification ( 21〇x 297 mm)

Loading --- (Please read the note on the back to write this page) · 1284020 A7 Stone - 5 9 Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing | 1 O ΓΠ s Ό n 1 S 1 GO 1 d • Ξ . Shoulder CO 2 '8 2 Q % d 2 pu to 1" X in GO - ο Ξ I! ρ§ Ι&gt; ο 二•S Special^ α ξ δ ι&gt; ο s ^ ^ σ ^ ρ g 1 贪§ ξ X ^ ρ p G § Ξ p P r Ο ζΛ on sx SO GO -g I s KJ\ o oo is p 0 5&gt; o zn I: 1 sgpi oo CO sg § oo 00 % ϊ ν〇ν〇ν〇ν〇 \j\ ν〇1 VO s ίο Lj s Ui •ss E sg S - bo sgi CTN LO UJ s 11 S UJ VV OJ .3⁄4 hv〇2 v〇vC \ VO hv〇卜K&gt; X Lj oo UJ oo S乂 00 ρ ζ 1 1 SS 〇〇| 2 v〇Ui ro s u&gt; .s NJ 2 LO ! Ui L/i 2 S v〇11 -S5 5 UJ V 乂N&gt; 2 oc LA Ui s 3 - Oc La - bo \j\ - ·〇〇- be NJ 5 V 2 Cv 乂ρ (Please read the note on the back---install--- write this page) % 1284020 A7 五\ly 6 9 Ministry of Economics Printed by the Property Bureau Staff Consumer Cooperative | &lt; | in 00 00 oooo 1 •Ξ s I s S 1 •s 2 d | GO δ 2 H - s 5 Ω In 〇 P ^ P “ 11 5 S b ^ IB P — o .° -η Ο 妄g ο P •o ·〇li 〇§ wp « Ml • • • O · 么 5 S · 〇S 绊x y1 y — O production S § 5 SO to X .00 y - o 十 S $ 11 11 x - o 丘寻 g -a 5 S §5 O.^ SI 11 托 j^3么 S § 〇§ I? X in 00 - Ο么•o · 么Is % UJ •NJ UJ l UJ δ U&gt; h UJ oo VVS UJ SO LO OO sia cool. 2 B NJ Ϊ Κ&gt; \ f〇s \ NJ .I ? , \ I UJ 3 乂VV GO 11 NJ •Os OJ UJ to · oo LO b\ uj •ii '5 K&gt; OJ 'i UJ I Ln i •s LJ •g fly 11 S5 3 , - be ! 〇〇- bo - oo Ϊ OO - bo \ oc - oo bo - oc UJ Oc f〇| l \ UJ •g \ l ;1 11 (Please read the note on the back---install----write this page) ·· Γ . 99 1284020 A7 B7 V. Description of invention (97) Economy Ministry of Intellectual Property Bureau employee consumption cooperative printing Ό Ό Ό α nnnn σ CD a CD &gt;&gt;&gt;&gt; NNN &lt;-&lt; XXX η in UJ H n 00 〇Lj H 〇00 L〇n C/3 0&quot;^ id U&gt; n 00 CD •υυ w ^ P ο kj\ ^ with in &gt; X r OJ 〇〇P ·&lt; 〇a 5 2 • ^ §g cn &gt; o • V-Λ τι Ο o (-Λ 00 &gt; xr 〇 〇oo w &gt;* 〇u* O 〇a 2 P 5 S • ^ §g 〇〇O s § # sp -P 〇Uo 〇〇0s s ^ &gt; 00 广^ &gt;&lt;^ σ,r 2 〇^ ^ ^ a &quot;npo 〇〇o^ isj ^ &gt; G c/3 r H(7) a .00 - 2: 〇 a 〇^ ^ ^ a -Γ1 p —ο .° '〇§g C/DX In CO -- , 0 a Ip &gt; 乂O -Ds. 〇V 2 oo V o % o V o ο • What oc NJ V LO '〇〇V UJ oo UJ 乂NJ LO 么NJ UJ 1» % Vt U • 丄x oc LO OC NJ La uj LO o $ •NJ OC UJ •g 1 s Ui % Xu V λ. VV '〇ro 二 On ΓΌ i ^ in § δ g ^ o •v〇NJ 〇λ. Ό UJ Ln ON o SJ ^J\ δ N) UJ 5 UJ • ON CN o UJ oc NJ OO V* u&gt; NJ • What $ 3; 11 f I ooo ίο ΓΟ • Ό UJ V UJ Lj o • Ό hO g UJ NJ 〇J ro 〇v〇LO .Vu&gt; Lo v〇- Ln \〇- cc 'v uj be s ^ g ^ 8 (Please read the note on the back first to write this page)

__襄P .- -This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 98 V. INSTRUCTIONS (Example 14 This example shows other compounds that can be used in the composition of the present invention Hydroxyl Solvent (Please read the note on the back &amp; -I --- π fill this page) · Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed -101 This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (&quot;) Ministry of Economic Affairs Intellectual Property Office Staff Consumer Cooperative Printed ο § -σ -ο -Ό 〇〇〇〇ζ 2: I z 2 2 2 rh · w Ml Ο Ο Ο Ο rn rn ΓΠ mm 〇 〇 Ο LO LO LO oo ο ν-ο OO o _〇o UJ UJ ο UJ ο ο f^s Uj 〇Lj 1”· ^ pt 〇·〇〇&gt; 5 〇T3 p Vn ·〇GO X 00 ο oc GO 5 ο ρ Ο 00 X cn 00 00 Ξ •ο -d ρ ο C0 X GO o &gt; ·〇-oppo 00 X CO ο &gt; μ Ο &quot;Τ3 Ο ρ ο 00 &gt;&lt;ί 00 o &gt; gopoo 00 X 00 o ϋι &gt; iNj •o •o -〇poo in X 00 L/&gt;&gt; o -appo cn X in o La &gt; •O soo on X GO o &gt; oo -D p Ξ O CO X 00 Ο Ρ ο X ^ 00 ^ Bu ο -&gt; Ρ r Ο 00 S 二^g π _ S o pr &gt; P ro in ^ 二 a 5 X * 〇00 ^ H po D! H ^ &quot;3 &gt;l〇&amp;5 lu X ^ GO , l· 乂NJ 3 •Ό VV* produces U) •ro ro vi •s V UJ •S % UJ •S - • s % UJ oc V UJ v〇VO - Ό VC V OJ Ό v〇V* UJ • v〇v〇V LO v〇v〇V UJ • Ό v〇V \7 II. Ten V χχ λ. λ '«CX ·&amp;· _〇isj La v〇UJ On U&gt; ro UJ VC UJ ^ 〇Q » ON ON Ui Μ Ln NJ Ο % bv UJ Uj ON n7 'What V • is • K) La oe LO La V • What L/i λ. 〇〇--4 oc CO Ν/ OC LO •g I Xt. o V LO V \7 ^ 〇§ g. ο UJ La OS UJ bo O k> I UJ bs ON i I 1 , - L〇〇UJ \/ -fc. 1 1 II 1 Employment 1 1 f 1 ON i • Ό Ό *v〇SJ Ό NJ fo UJ o E § UJ to ON OJ *O 2•2 LJ •ro UJ 2 ^ 1 1 I 1 1 1 V; OC to VI 1 1 1 I 1 1 1 1 1 1 I [%k •Ό LO UJ ON •s 'as oc s ·- -102- ---- -----------Install---(Please read the notes on the back first) Write this page) book: This paper scales applicable Chinese National Standard (CNS) A4 size (210 X 297 mm) 1284020 A7

1284020 A7 B7 V. INSTRUCTIONS () In addition to the observation that other solvents (e.g., PG and TPG) can also be used in the compositions of the present invention, products JJJJ through 0000 can illustrate other effects of the relative saturation of the antimicrobial agent in the system. The relative % saturation (highest to lowest) of the first three compositions is JJJJ>KKKK&gt;LLLL. Composition KKKK has a composition of JJJJ one-third the amount of TCS dissolved in the same amount (0.5%) of ALS, while composition LLLL contains 0% TCS. Significant reduction in activity can be observed for Klebsiella pneumoniae and Salmonella cholerae when the relative % saturation of TCS is reduced in the composition. It has also been observed that when the relative % saturation is substantially equal (i.e., about 100%), the activity and maintenance are substantially constant, even if the absolute content of TCS is reduced in the composition (i.e., the comparative composition MMMM pair NNNN). These data can further support the observations on the importance of % saturation as described in Example 7. In addition, a comparison of composition IIII with composition TTTT showed that the composition TTTT contained slightly less ALS (0.9°/. 1.0% for IIII), the same amount of PG (10.0%), and one-half the content. SXS (5.0% vs. 13.1% of IIII). Experimental observations indicate that compositions IIII and TTTT are 100% saturated or nearly 100% saturated. However, the log reduction of the composition TTTT against E. coli was significantly lower (about 4 log). This observation further supports the data described in Example 8, which shows that a minimum level of solubilizer may be required to produce high antibacterial activity against at least some of the Gram-negative bacteria. Example 15 The following compositions 15-A to 15-D were prepared to illustrate the preferred bacterial killing effect of the compositions of the present invention over control group compositions (i.e., compositions containing no antimicrobial agents), Even in the case where there is a very low level of disinfecting alcohol. Composition 15A-15D is made using standard mixing techniques known in the art -104- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) (please read the note on the back first) Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1284020 A7 V. Description of the invention (Ready. Table 4 below shows the composition of the composition. 矣$ Β|ϊ 4士丄

Sickle Table 5 below summarizes the antimicrobial efficacy of the compositions 15-Α to 15-D, as measured by a time-limited kill test. ---r----------装--- (Please read the note on the back of the page to fill in this page) ·. Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed table 5 composition 15 seconds / Logarithmic reduction of 30 seconds S. aureus E. coli K· pneum. S. chol 15·Α 0.55/1.73 0.18/0.43 1.15/0.71 2.51/4.24 15-Β 3.27/&gt;4.43 3.75/&gt;4.51 1.33/3.10 4.09 /4.34 15-C 0.01/0.0 0.17/0.12 0.4/0.H 0.18/0.17 15-D &gt;4.43/&gt;4.43 3.20/3.48 3.19/4.03 2.86/3.99 Example 15 illustrates the composition of the present invention (15-B and 15-D) Accidental efficiency, where -105-

Table 4 Composition % Weight Friends | 匕 (based on active material) TCS Ethanol PPG-9 DPG Water 15-A (Control Group) 0 25.86 11.5 Equilibrium 15·Β 0.10 25.86 11.5 — Balance 15_C (Control Group) 0 23.0 — 11.18 Balance 15-D 0.10 23.0 — 11.18 Balance This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 Β7 _ V. Invention description (1()3) Observable sacrifice to the south logarithm reduction Both blue positive and negative blue negative bacteria, even for compositions containing less than 26% ethanol. These results are dependent on high alcohol concentrations (i.e., greater than about 40%) relative to the compositions described in the previously disclosed documents to achieve a high and wide range of antimicrobial activity. Example 16 Example 16 shows that the compositions of the present invention provide excellent, broad range of antimicrobial activity, even at further reduced alcohol concentrations. Thus, Composition 16-A was prepared containing 0.15% TCS, 11.18% ethanol, 25.71% DPG, and was weighed as a weight percent of the active compound. For comparison, the same control group composition 16-B was prepared except that composition 16-B contained no TCS. The following table summarizes the antibacterial efficacy of the compositions 16-A and 16-B measured by the time-limited killing test -.l·----------Install·—— — (Please read the back of the note first) Write this page)

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The Intellectual Property Department of the Ministry of Economic and Social Affairs X Consumer Cooperative Printed Example 16 further illustrates that the alcohol concentration in the composition of the present invention can be reduced by (eight) to very low levels without sacrificing antimicrobial activity. Therefore, a composition which provides excellent antibacterial effects without drying the skin can be prepared. Compositions that previously relied on high alcohol concentrations to achieve antimicrobial efficacy will dry the skin and will usually puncture the skin.曰, 7 Χμλι -106 - 1 1284020 A7 B7 V. INSTRUCTION DESCRIPTION () Example 17 illustrates that the high-efficiency composition of the present invention can incorporate p-chloro-m-xylphenol (PCMX) as an antibacterial active agent. Composition 17_A was prepared by mixing 0.1% PCMX, 13.42% ethanol, and water equilibration (based on weight percent of active compound). The antibacterial efficacy of composition 17-A was evaluated by a time-limited killing test, and it had 4.16 against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Salmonella cholerae, respectively, within a contact time of 30 seconds. &gt;4.34, 3.99, and &gt; 4.04 log reduction. Thus, Composition 17-A is an effective antimicrobial composition, although the composition contains very low concentrations of ethanol. Example 18 Example 18 illustrates a composition of the invention containing a cationic gelling agent CELQUAT CS-230M. By mixing 0.15% TCS, 28% ethanol, 11.18% DPG, and 2% CELQUAT CS-230M, and in water balance (except CELQUAT CS-230M, which is "as such" by weight of active compound) ) to prepare composition 18-A. The antibacterial efficacy of Composition 18-A was evaluated by a time-limited killing test. Composition 18-A was found to be resistant to Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Salmonella cholerae, respectively, within a contact time of 30 seconds. &gt; 3.83, 4.33, &gt; 4.43, and &gt; 3.55 log reduction. Thus, Composition 18-A is a highly effective antimicrobial composition, although the composition contains very low concentrations of ethanol. EXAMPLE 19 The compositions of the present invention may contain a wide variety of gelling agents, hydroxy solvents, and antibacterial active agents, as illustrated by the following examples. In Table 6 below, all weight percentages are based on the active substance, except those specified by "*", which represents the weight of "as it is". These compositions are based on the Chinese National Standard (CNS) A4 specification (210 X 297 mm). (Please read the note on the back to write this page.) Ministry of Economic Affairs Intellectual Property Office staff Consumer Cooperatives Printed 1284020 A7 B7 V. INSTRUCTIONS (1〇5) Well-known mixing and gel preparation techniques. These compositions have acceptable clarity, stability, and performance. (Please read the note on the back to write this page) Installed by the Ministry of Economic Affairs, Intellectual Property Bureau, Staff and Consumer Cooperatives -108- This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Description of the invention (1〇6) Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed l· a C Η g N Ξ 箐-a η X η mc &gt; HQ r〇I 普 n &gt; 〇zmxr* 〇黄σ &quot; D -ϋ o V〇fN l·器-5 &gt; r- iS &gt; or σ &lt; 普^Γ d 〇\ Ξ OC l-Λ 3: •s 〇&gt; K) UJ Ξ 3: ·〇CD Ro UJ ο 〇η Lo r〇LO S 〇σ CN 3 s 〇oo h〇u&gt; ο s 〇ΤΙ UJ 5 •S 〇Ο •Νύ LA ο 〇3: work oc ro u&gt; ο S 〇&quot; ·: Jo vC LO 〇«Μ -109 - (Please read the note on the back 4 -I --- iiw write this page) · -Γ . . This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 public) PCT) 1071284020 A7 B7 V. INSTRUCTIONS () Employees of the Intellectual Property Office of the Ministry of Economic Affairs Consumer Cooperatives Printing C Η cn N JO s X η CT3 C &gt; Η Q NJ LO Ο 2 issues r &gt;&quot;3 ozm X r 〇* a *T3 oo sy l· =5 &gt; Wide c CD &gt ; amra &lt; * 00 ON c: •NJ pc: I: ^r\ •o Γ to OO o 2 oc LO so NJ oo LO Ky\ so 〇NJ o *ro oo K&gt; oo -go &quot;Ο ro oo Oo to 00 sp 〇〇〇Lj ο zz ro U) s 〇•S 〇LO •Ο l to oo o 00 〇〇L» ο &quot;S Η -110 - (Please read the note on the back to fill out this page) • Binding: -Γ . . This paper scale applies to China National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. Invention Description (1()8) All the data shown in the above table and example are It is shown that the % saturation of the antimicrobial agent in the aqueous phase of the composition can be directly related to the log reduction of the bacteria. By way of example, as shown in the preceding table, the composition having a TCS 5〇% saturation in the aqueous phase shows a log reduction of 1.96 (30 seconds) and 3.05 (60 seconds) against Staphylococcus aureus, and 2.45 (30 seconds) And a logarithmic reduction of greater than 3.81 (60 seconds) against E. coli. The 75% saturated and 1% saturated compositions have a log reduction of greater than 4 55 (3 and 6 sec) against Staphylococcus aureus (i.e., a log reduction in excess of analytical detection limits). The 75% and 1% saturated compositions of 泫 and so on have 34 〇 (3 〇 seconds) and greater than 3.81 (60 sec), respectively, and logarithmic reductions greater than 3.81 (3 〇 and 6 〇 seconds) against E. coli. Accordingly, the antimicrobial compositions of the present invention can be characterized as having a log reduction of at least about 2 (after 30 seconds) or at least about 3 (after 60 seconds) against Staphylococcus aureus, or having at least about 2.5 (after 30 seconds) or at least The logarithm of about 35 (after 6 sec) is reduced against the large bacilli. The antimicrobial compositions of the present invention can have a number of end-use applications including hand cleansers, mouthwashes, surgical scrubs, body sprays, hand sanitizing gels, and the like. Other types of compositions include foam compositions (such as creams, mousses, and the like), as well as compositions containing organic or inorganic fillers (such as emulsions, lotions, creams, ointments, and the like). These compositions are also useful as antibacterial cleansers for hard surfaces such as hospital sinks and countertops, food supply areas, and meat processing plants. The antibacterial composition of the present invention can be produced as a diluted ready-to-use composition or can be prepared as a concentrate diluted before use. These compositions can also be incorporated into a mesh material to provide an antimicrobial wipe. The wipe can be used to clean and disinfect skin and inanimate surfaces. -111 - This paper size is applicable to China National Standard (CNS) A4 specification (21 7_297 publicity) one (please read the note on the back to fill out this page) Binding: Ministry of Economic Affairs Intellectual Property Bureau Staff Consumer Cooperative Printed 1284020 A7 109 5, the invention description (the invention (anti-caries composition can be provided in the short rose> 匕 also aa cut in the actual contact time to kill the stagnation of the dangerous singularity of the singular bacteria.., ancient. It is generally used to clean and eliminate the maternal skin and the inanimate surface of the 丨 5 to 6 〇 · 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 、 The composition can exhibit an effective sputum present in the continuous phase of the water of the composition in a short contact time. Thus, the antibacterial agent can immediately begin to reduce the bacterial population, = attached to the skin In order to provide residual antibacterial effect. In addition, since the antibacterial agent is present in the falling liquid instead of the surfactant microcapsule, the absolute content of the antibacterial agent in the group can be reduced without adversely affecting its efficacy, and resistance Two doses will not be on display Before the fungicidal function, it is washed away from the skin together with the interfacial activity. In addition, the surfactant content in the antibacterial composition of the present invention is relatively low, thus providing an additional environmental benefit. The following examples illustrate the present invention. Various compositions.Example 20 Hand Wash Compositions The compositions of the present invention are suitable for use as hand-washing agents. The compositions contain the following percentages by weight: mouth (please read the notes on the back! Fill in this page) •-襄. Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing -112- This paper scale applies China National Standard (CNS) A4 specification (210 X 297 mm 1284020 A7 V. Invention Description (UG)

Ingredients ------ Weight percent triclosan--^~_ 0.3 12-base sulfuric acid press -~~_ 0.75 dipropylene glycol----- 5.0 sodium xylene sulfonate-------- - 10.0 Fragrance 0.05 Water qs - "-_J (Please read the note on the back first - install i - &gt; fill this page) This composition is prepared by mixing dipropylene glycol, TCS, and fragrance until uniform (about 5 minutes). After the triclosan is completely dissolved (as confirmed by the undissolved solid matter), sodium xylene sulfonate is added to the solution. Stir again: The resulting mixture was dissolved until sodium xylene sulfonate was completely dissolved (about 5 minutes). Finally, ammonium lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about 5 minutes). The Λ composition has a 2.5:1 surfactant/·Triclosan weight ratio and is at least about 90% trisaturated. The antibacterial efficacy of the composition against Staphylococcus aureus and colonic bacteria was evaluated using a time-limited killing test. Against the Staphylococcus aureus, the composition had a logarithmic reduction of &gt; 4·07 in 30 seconds, whereas against E. coli, the composition had a logarithmic reduction of 3.90 in 30 seconds. Therefore, the composition has an excellent wide range of antibacterial activity. At the same time, the pain grade stone is an excellent hand lotion composition in the actual use test, and can provide an excellent clean and smooth feeling at the same time. · Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printed -113-

1284020 A7 B7 V. INSTRUCTIONS (Example 2) Body Spray Compositions The compositions of the present invention suitable for use as body sprays are prepared using the following percentages by weight: Component Weight Percentage Triclosan 0.3 Alkyl Polyglucose 0.3 propylene glycol 14.4

The composition is prepared by combining tri-male, propylene glycol, perfume, ethanol, and mixing the components until all three gas is dissolved (and confirmed by the Z-helster dissolved solid matter). Further, sodium xylene sulfonate was added, and the resulting mixture was mixed until the sodium xylene sulfonate was completely dissolved. Finally, the alkyl polyglucose and water were added and the mixture was stirred until the same sentence. The resulting composition forms a fine and refreshing body spray which provides a bacterial reduction of the user's skin S 2 scale. ^^122

(Please read the note on the back first. S U5T--- 1 Fill in this page) Printed by the Intellectual Property Office of the Ministry of Economic Affairs

-114-

1284020 A7 V. INSTRUCTIONS (112) Mouthwash Compositions The compositions of the invention suitable for use as mouthwashes are prepared using the following percentages by weight: 0.3 0.3 14.4 10.0 10.0 0.05 qs The preparation of the composition is by combination The alcohol, the odorant, and the pharmaceutically acceptable alcohol are mixed in any conventional manner until all of the bismuth is dissolved (which is confirmed if there is no undissolved solid matter). Ministry of Economic Affairs, Intellectual Property Bureau, employee consumption cooperative, printing

Percent by weight----1---------- Pack--- (Please read the note on the back* to fill out this page) = Add sodium mono-toluenesulfonate and stir the mixture until two Sodium formate is completely dissolved. Finally, 'adding alkyl polyglucose and water, and then stirring: the composition until the hook is obtained to form a fine and refreshing ten-mouth factory = for the user's teeth, silver teeth, and the degree of the target on the tongue'囷, less examples 23 -115-

1284020 A7 I--------------- B7 V. INSTRUCTIONS (113) Wet wipes compositions are prepared by using the following components in the weight percentages to prepare wet wipes suitable for impregnating non-woven materials. The composition of the present invention: component weight percentage triclosan---------- 0.3 decyl sulphuric acid 0.75 dipropylene glycol 5.0 sodium xylene sulfonate 15.0 water qs 泫, 'and 6 The preparation is carried out by combining triclosan and dipropylene glycol and mixing the components until all triclosan is dissolved (as confirmed by the absence of undissolved solid matter). Further sodium xylene sulfonate was added and the resulting mixture was stirred until the sodium xylene sulfonate was completely dissolved. Finally, ammonium lauryl sulfate and water were added, and the mixture was stirred until the same sentence. The bird then dipped a piece of non-woven cellulosic material (i.e., t into the composition to form a scouring article suitable for wiping and clearing the surface, for example, a hand. The article forms an excellent wet wipe, The impregnated antimicrobial composition can be freely expressed from the web to provide a wide range of antibacterial activity. Several Examples 24 Hand Wash Groups Prepare a composition of the present invention suitable as a hand lotion. The composition contains a solution (please read the back note first) ί -装--- 1 Fill in this page&gt; ·. Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative printing -116·

1284020 A7 B7 V. INSTRUCTIONS INSTRUCTIONS (refers to the following components by weight) Chloramphenicyl ammonium dithiocarbamate Propylene glycol

(Please read the note on the back to fill out this page.) Installation Printed by the Ministry of Economic Affairs, Intellectual Property Office, Staff Consumer Cooperative I. The preparation of the composition was carried out by first mixing tri-gas and dipropylene glycol until uniform (about 5 minutes). After the three gas is completely dissolved (as confirmed by the solid matter of the helmet), the xylene cross-acid is added to the solution. Further, the resulting mixture was completely dissolved in sodium xylene sulfonate (about 5 minutes). Finally, ammonium lauryl sulfate and water were added to the resulting solution, and the composition was stirred until homogeneous (about 5 minutes). The composition has a 2.5:1 surfactant: triclosan weight ratio and is at least about 9 angstroms per liter of diclosan. The antibacterial efficacy of the composition against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Salmonella cholerae was evaluated using a time-limited killing test and a contact time of 30 seconds. The composition had a logarithmic reduction of &gt; 3 59, &gt; 4 49, &gt; 3 2〇, and &gt; 4 knives against the four test microorganisms, respectively. ^ Therefore, the composition has an excellent range of antibacterial activity. In addition, the oral substance is an excellent hand-washing agent combination in the use test only -117-

1284020 A7 B7 V. INSTRUCTIONS (115) The object can provide an excellent clean and smooth feeling at the same time. Example 25 vs. Pre-existing 7JT Compositions This 5 cases compare the antibacterial efficacy of the antibacterial compositions of the present invention with a previously disclosed composition. Thus, the composition of Example 24 was compared to a single example disclosed in w〇 98/01110. In both compositions, the active antibacterial agent is triclosan (TCS). Both compositions were tested for their antibacterial efficacy against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Cholera cholerae in a time-limited killing test. An example of w〇98/01110 was tested at a 50% dilution according to the test procedure for the viscous composition. The following data summarizes the percentage of active antimicrobial agent in each composition at the test dilution (i.e., the test dilution is 1% for the composition of Example 24, and 50% for the example of w〇98/01110). And the logarithm reduction observed in the contact time in the time-limited killing test is 0--- (please read the note on the back to fill out this page) · · Printed by the Intellectual Property Office of the Ministry of Economic Affairs

This example illustrates the preferred time-limited killing performance of the compositions of the present invention over the composition of the millennium y, especially against the smectic bacteria. This one excellent -118-

1284020 A7 116, V. Description of the invention (The opposite sex may even be described by a specific composition containing a significantly more active antibacterial agent than the composition of the invention. Thus, the composition of the invention may be more effective in the use of an active agent, which may A higher log reduction result when using a low concentration of antimicrobial agent. Example 26

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Compared with the previously disclosed composition, the composition of the composition of the present invention is compared with the antibacterial composition of the previously disclosed composition of the antibacterial composition of the present invention. Thus, the composition of Example 24 and the composition disclosed in WO 96/06152 were compared. W〇 96/〇6152 discloses an effective composition comprising TCS, an anionic surfactant, a solubilizing agent, a hydroxy solvent, and an organic acid, specifically a citric acid. W〇96/〇6152 contains additional pH adjustments such as monoethanolamine and sodium hydroxide. Meanwhile, the example disclosed in WO 96/06152 has a pH of 4 or 9.1, and none of the examples has a desired neutral pH of about 7. A positive value of about 7 is a composition that contacts the skin or an inanimate surface, as compositions having a positive value other than 7 (such as 4 or 9 1) are more likely to damage the surface to which they are exposed. Thus, a composition of Example 1 (which is hereinafter referred to as Composition 26_A) was prepared. For comparison, composition 26-A was prepared as above, except that additional monoethanolamine was added to adjust the pH to 7 (this composition is hereinafter referred to as composition 26-B). To provide an additional comparison, the composition of Example 3 of W〇96/06152 was prepared, except that it was prepared by adding additional monoethanolamine to pH 7 (this composition is hereinafter referred to as composition 26·〇. The compositions of this example are tested against the indicated bacteria in a time limit of % seconds in a time-limited killing test. -119- This paper scale applies to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 1284020 A7 B7 V. INSTRUCTIONS (117, - Composition pH %TCS 30-second log reduction S. aureus Ε· coli Κ· pnenm. S· choler. Example 24 7.1 0.3 &gt;4.54 &gt;4.25 3.67 &gt;4.77 Comparative 26-A 4 0.075 — &gt;4.84 --Comparative 26-B 7 0.075 — — 0.07 A comparative 26-C 7 0.15 4.44 2.91 0.28 4.67 Read this consistent example on the back side 'At a pH of about 7 The composition of the present invention has a better time-limited killing performance than the prior composition, particularly in the case of against Gram-negative bacteria. The data shown in this example can be concluded, the composition of WO 96/06152 is essential Relying on relatively extreme pH values (4 or 9), It is disclosed to achieve a rapid and wide range of bacterial population reductions. This, in contrast to Example 18 of the present invention, provides a rapid range of bacterial killing at a desired pH of about 7. Example 27 The composition of the present invention containing p-chloro-m-xylenol (PCMX) as an active antibacterial agent is prepared by the antibacterial fineness containing PCMX. The composition contains the following components by weight percentage: · -120- The paper scale applies to the Chinese National Standard (CNS) A4 specification (21〇x 297 mm). The Ministry of Economic Affairs Intellectual Property Bureau employee consumption cooperative prints 1284020 A7 I--------- R7_ V. Invention Description (118 )

f Please read the note on the back - binding ·. The composition is at least about 9〇% pCMX saturated. The antibacterial efficacy of the composition against Staphylococcus aureus, colonic bacteria, Klebsiella pneumoniae, and Salmonella choleraesuis was evaluated using a time-limited killing test. Against Staphylococcus aureus 'The composition has a logarithmic reduction of 416 in 30 seconds; against E. coli' the composition has a logarithmic reduction of &gt; 4.34 in 30 seconds; against Klebsiella pneumoniae, the composition With a logarithmic reduction of 3 99 in 3 sec and against Salmonella choleraesuis, the composition had a logarithmic reduction of &gt; 4.04 in 30 seconds. Therefore, the composition has excellent activity of printing in a wide range of Fanyuan Antibacterial Economic Department Intellectual Property Bureau employee consumption cooperatives. Example 28 A scab composition containing PCMX A composition of the present invention incorporating p-chloro-m-nonylbenzene S as an active antibacterial agent was prepared. The composition contains the following components by weight: -121 - This paper size applies to the Chinese National Standard (CNS) A4 specification (21〇x 297 mm) 1284020 A7 B7 119 V. Inventive Note () Component Weight Percentage PCMX 0.3 Ammonium dodecyl sulfate 0.8 water qs The composition is prepared by first combining PCMX and water, then adding ammonium lauryl sulfate, and mixing the components until the components are completely mixed and the PCMX is dissolved. (about 2 hours). The composition is at least about 90% PCMX saturated. The antibacterial efficacy of the composition against Staphylococcus aureus and Escherichia coli was evaluated using a time-limited killing test. For Staphylococcus aureus, the composition had a logarithmic reduction of &gt; 3.57 in 30 seconds; and against E. coli, the composition had a logarithmic reduction of &gt; 4.17 in 30 seconds. Therefore, the composition has an excellent range of antibacterial activity. It is to be understood that the invention may be modified and varied without departing from the spirit and scope of the invention. --------------装--- (Please read the note on the back to fill out this page) Printed by the Intellectual Property Office of the Ministry of Economic Affairs

If · -122- This paper size applies to China National Standard (CNS) A4 specification (210 X 297 mm)

Claims (1)

1284Q but 112409 patent ^ case 4: go, | greed Chinese application for patent scope for the elimination of Zhu ^ 篆年法 @ i&gt;\ VI. Application for Patent Park 1. An antibacterial composition comprising: (a) 3% to 5% by weight of triclosan as an antibacterial agent; (b) 0.1% to 15% by weight of a surfactant, Or a mixture of anionic surfactants, amphoteric surfactants or mixtures thereof; (c) 2% to 40% by weight of solubilizer; (d) 2% to 60% by weight of water-soluble solvent; (e) water Wherein the composition has a p Η value of 5 to 8, and wherein the antimicrobial agent is present in an amount of at least 5% saturation concentration when measured at room temperature. 2. The composition of claim 1, wherein the surfactant is present in an amount of up to 5% by weight. 3. The composition of claim 2, wherein the surfactant is present in an amount of up to 2% by weight. The composition according to any one of claims 1 to 3, which comprises a solubilizing agent and a solvent. 5. The composition of claim 4, wherein the antibacterial agent is present in an amount of 75% less saturated. &lt;6. The composition of claim 5, wherein the antibacterial agent is present in an amount of at least 95% saturated concentration. The composition according to any one of claims 1 to 3, wherein the dream solvent is present in an amount of from 2% to 25% by weight. 8. The composition according to item 7 of the patent application' wherein the solubilizing agent is present in an amount of from state to 20% by weight. &quot; ° 64808-960419.doc β1 . The paper size is moderate Η @家料(CNS) Α4 specification (210 X 297 mm) ----___ A8 B8 C8 D8 1284020 VI. Application for patent garden 9·According to application The composition of any one of the preceding claims, wherein the hydrazine solvent is present in an amount from 2% to 20% by weight. A composition according to claim 9 wherein the hydroxy solvent is present in an amount of up to 15% by weight. The composition according to any one of claims 1 to 3, wherein the hydroxy solvent comprises an alcohol, a diol, a triol, and a mixture thereof. The composition according to any one of claims 1 to 3, wherein the hydroxy/spring agent comprises methanol, ethanol, isopropanol, n-butanol, n-propanol, ethylene glycol, propylene glycol, Glycerin, diethylene glycol, dipropylene glycol, tripropylene glycol, hexanediol, butanediol, 1,2,6-hexanetriol, mannitol, PEG-4 or a mixture thereof. The composition according to any one of claims 1 to 3, wherein the enhancer is selected from the group consisting of sodium cumyl sulfonate, ammonium isopropyl phthalate, xylene dimethyl ammonium, and toluene. Sour rape, sodium toluenesulfonate, sodium dihydrochloride, toluic acid, xylenesulfonic acid, sodium polysodium citrate, sodium polystyrene sulfonate, sodium methylnaphthalene sulfonate, disodium succinate and mixtures thereof . The composition according to any one of claims 1 to 3, wherein the three milks are present in an amount of from 5% to 2% by weight of 〇·〇. The composition according to any one of claims 3 to 3, wherein the surfactant is selected from the group consisting of sodium lauryl sulfate, ammonium lauryl sulfate, monoethanolamine lauryl sulfate, Triethanolamine lauryl sulfate, dodecyl sulfate clock, magnesium lauryl sulfate, sodium octyl sulfate, 2-ethylhexyl sulfate steel, sodium decyl sulfate, sodium tridecyl sulfate, C! 2 ·〗 8-alkyl sodium sulfate, potassium coconut oleate, potassium oleate, potassium laurate, dodecyl ether sulfuric acid 64808-960419.doc _ 2 _ This paper scale applies to China National Standard (CNS) A4 specifications (210 X 297 mm) A8 B8 C8 D8 1284020 VI. Application for patents Fan Sodium, tetradecyl ether-4 carboxylate, octoxynol-9, oxidized dodecylamine, sodium dodecyl sarcosinate, Disodium lauryl sulfosuccinate, sodium lauryl sulphate, methyl sulphonate, α-indole hydroxamate, c 1 〇 (linear) oxidized diphenyl sulphate, coconut Oil amphoteric acetate steel, coconut melamine propyl betaine and alkyl polydextrose. The composition according to claim 15 wherein the surfactant comprises sodium lauryl sulfate, sodium octyl sulfate, sodium 2-ethylhexyl sulfate or oxidized dodecylamine. 17. The composition according to claim 1, which comprises (a) 0.01% to 0.5% by weight of triclosan; (b) 0.1% to 5% by weight of a surfactant; (c) 5% a solubilizer to 20% by weight; and (d) a solvent of 2% to 15% by weight. The composition according to any one of claims 1 to 3, which has a logarithmic reduction of at least 2 against Gram-positive bacteria after contact for 3 sec (which is measured against Staphylococcus aureus) And it has a log reduction of at least 2.5 against Glan-negative bacteria after 3 sec. contact (as measured against E. coli 5. cW). The composition of any one of claims 1 to 3 for use in a method of reducing bacterial populations on the skin of a mammal, the method comprising contacting the surface with the composition for 30 seconds to achieve The composition is washed away from the skin by against at least 2 against Staphylococcus aureus and at least 2.5 against E. coli. 20. The composition according to claim 19, wherein the composition is in contact with the 64808-960419.doc Order 1284020 Patent application scope U table for 60 seconds to achieve a logarithmic reduction of at least 3 against Staphylococcus aureus. The composition of claim 19, wherein the composition contacts the surface for 60 seconds to achieve a log reduction of at least 3.75 against E. coli. 22: The composition of claim 19, wherein the composition contacts the watch for 30 seconds to achieve a log reduction of at least 2 against Klebsiella pneumoniae. 23 ways to reduce the bacterial population on the surface, including bringing the surface into contact according to the scope of the patent application! The composition of any of items 8 to 3 seconds to achieve a log reduction of at least 2 against Staphylococcus aureus and at least 2. 5 against E. coli and the composition is washed away from the surface. 24_ The method of claim 23, wherein the composition contacts the surface for 60 seconds to achieve a log reduction of at least 3 against Staphylococcus aureus. The method of claim 23, wherein the composition contacts the surface for 60 seconds to achieve a log reduction of at least 3.75 against E. coli. 26. The method of claim 23, wherein the composition contacts the surface for 30 seconds to achieve a log reduction of at least 2 against Klebsiella pneumoniae. ' Λ 64808-960419.doc This paper size is applicable to China National Standard (CNS) Α4 specification (210X297 mm)