TW552258B - Thermodynamically stable form of (R)-3-[[(4-fluorophenyl)sulphonyl]-amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid) (ramatroban) - Google Patents
Thermodynamically stable form of (R)-3-[[(4-fluorophenyl)sulphonyl]-amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid) (ramatroban) Download PDFInfo
- Publication number
- TW552258B TW552258B TW087121479A TW87121479A TW552258B TW 552258 B TW552258 B TW 552258B TW 087121479 A TW087121479 A TW 087121479A TW 87121479 A TW87121479 A TW 87121479A TW 552258 B TW552258 B TW 552258B
- Authority
- TW
- Taiwan
- Prior art keywords
- bay
- variant
- colorless
- ptp
- cpp
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19757983A DE19757983A1 (de) | 1997-12-24 | 1997-12-24 | Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban) |
Publications (1)
Publication Number | Publication Date |
---|---|
TW552258B true TW552258B (en) | 2003-09-11 |
Family
ID=7853457
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW087121479A TW552258B (en) | 1997-12-24 | 1998-12-23 | Thermodynamically stable form of (R)-3-[[(4-fluorophenyl)sulphonyl]-amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoic acid) (ramatroban) |
Country Status (37)
Country | Link |
---|---|
US (1) | US6362214B1 (de) |
EP (1) | EP1051398B1 (de) |
JP (2) | JP3817668B2 (de) |
KR (1) | KR100586350B1 (de) |
CN (1) | CN1140510C (de) |
AR (1) | AR013803A1 (de) |
AT (1) | ATE263152T1 (de) |
AU (1) | AU744242B2 (de) |
BG (1) | BG65024B1 (de) |
BR (1) | BR9814496A (de) |
CA (1) | CA2313230A1 (de) |
CO (1) | CO4970800A1 (de) |
DE (2) | DE19757983A1 (de) |
DK (1) | DK1051398T3 (de) |
ES (1) | ES2218874T3 (de) |
GT (1) | GT199800198A (de) |
HK (1) | HK1034517A1 (de) |
HN (1) | HN1998000186A (de) |
HU (1) | HUP0004432A3 (de) |
ID (1) | ID25446A (de) |
IL (1) | IL136278A (de) |
IN (1) | IN192932B (de) |
MY (1) | MY116312A (de) |
NO (1) | NO316618B1 (de) |
NZ (1) | NZ504741A (de) |
PE (1) | PE20000115A1 (de) |
PL (1) | PL341359A1 (de) |
PT (1) | PT1051398E (de) |
RU (1) | RU2220137C2 (de) |
SI (1) | SI1051398T1 (de) |
SK (1) | SK285109B6 (de) |
TR (1) | TR200001936T2 (de) |
TW (1) | TW552258B (de) |
UA (1) | UA66832C2 (de) |
UY (2) | UY25324A1 (de) |
WO (1) | WO1999033803A1 (de) |
ZA (1) | ZA9811817B (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100168137A1 (en) * | 2006-12-20 | 2010-07-01 | Johan Raud | Combination for use in the treatment of inflammatory disorders |
CA2675520A1 (en) * | 2007-01-16 | 2008-07-24 | Cardoz Ab | New combination for use in the treatment of inflammatory disorders |
WO2009007674A2 (en) * | 2007-07-11 | 2009-01-15 | Cardoz Ab | Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast |
CN101434571B (zh) * | 2007-11-13 | 2012-05-30 | 杭州容立医药科技有限公司 | 环烷并[1,2-b]吲哚磺酰胺、其异构体或其盐的合成方法 |
WO2011115069A1 (ja) * | 2010-03-19 | 2011-09-22 | 第一三共株式会社 | 結晶の網羅的探索 |
CN103054857A (zh) * | 2012-12-30 | 2013-04-24 | 北京阜康仁生物制药科技有限公司 | 一种以雷马曲班为活性成分的固体制剂 |
JP6770522B2 (ja) | 2015-02-13 | 2020-10-14 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 全身性エリテマトーデスを予防し、及び/又は、治療するためのptgdr−1及び/又はptgdr−2アンタゴニスト |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3631824A1 (de) | 1986-02-21 | 1988-03-31 | Bayer Ag | Cycloalkano(1.2-b)indol-sulfonamide |
CN1015711B (zh) | 1986-02-21 | 1992-03-04 | 拜尔公司 | 制备环烷并[1,2-b]吲哚-磺酰胺类化合物的方法 |
DE19506739A1 (de) | 1995-02-27 | 1996-08-29 | Bayer Ag | [3-Amino]-tetrahydrocarbazol-propansäureester |
-
1997
- 1997-12-24 DE DE19757983A patent/DE19757983A1/de not_active Withdrawn
-
1998
- 1998-12-09 HN HN1998000186A patent/HN1998000186A/es unknown
- 1998-12-11 AR ARP980106318A patent/AR013803A1/es unknown
- 1998-12-15 GT GT199800198A patent/GT199800198A/es unknown
- 1998-12-22 MY MYPI98005837A patent/MY116312A/en unknown
- 1998-12-22 PE PE1998001272A patent/PE20000115A1/es not_active Application Discontinuation
- 1998-12-23 TW TW087121479A patent/TW552258B/zh not_active IP Right Cessation
- 1998-12-23 UY UY25324A patent/UY25324A1/es not_active IP Right Cessation
- 1998-12-23 ZA ZA9811817A patent/ZA9811817B/xx unknown
- 1998-12-23 CO CO98076459A patent/CO4970800A1/es unknown
- 1998-12-24 US US09/582,250 patent/US6362214B1/en not_active Expired - Fee Related
- 1998-12-24 IN IN43MU2000 patent/IN192932B/en unknown
- 1998-12-24 DK DK98961506T patent/DK1051398T3/da active
- 1998-12-24 RU RU2000119741/04A patent/RU2220137C2/ru not_active IP Right Cessation
- 1998-12-24 SK SK975-2000A patent/SK285109B6/sk unknown
- 1998-12-24 HU HU0004432A patent/HUP0004432A3/hu unknown
- 1998-12-24 PL PL98341359A patent/PL341359A1/xx not_active Application Discontinuation
- 1998-12-24 DE DE69822882T patent/DE69822882T2/de not_active Expired - Fee Related
- 1998-12-24 PT PT98961506T patent/PT1051398E/pt unknown
- 1998-12-24 IL IL13627898A patent/IL136278A/xx not_active IP Right Cessation
- 1998-12-24 UA UA2000074335A patent/UA66832C2/uk unknown
- 1998-12-24 WO PCT/JP1998/005844 patent/WO1999033803A1/en not_active Application Discontinuation
- 1998-12-24 TR TR2000/01936T patent/TR200001936T2/xx unknown
- 1998-12-24 CA CA002313230A patent/CA2313230A1/en not_active Abandoned
- 1998-12-24 BR BR9814496-0A patent/BR9814496A/pt not_active Application Discontinuation
- 1998-12-24 EP EP98961506A patent/EP1051398B1/de not_active Expired - Lifetime
- 1998-12-24 ES ES98961506T patent/ES2218874T3/es not_active Expired - Lifetime
- 1998-12-24 AT AT98961506T patent/ATE263152T1/de not_active IP Right Cessation
- 1998-12-24 SI SI9830656T patent/SI1051398T1/xx unknown
- 1998-12-24 ID IDW20001226A patent/ID25446A/id unknown
- 1998-12-24 AU AU16874/99A patent/AU744242B2/en not_active Ceased
- 1998-12-24 JP JP2000526487A patent/JP3817668B2/ja not_active Expired - Lifetime
- 1998-12-24 KR KR1020007007031A patent/KR100586350B1/ko not_active IP Right Cessation
- 1998-12-24 NZ NZ504741A patent/NZ504741A/xx unknown
- 1998-12-24 CN CNB98812405XA patent/CN1140510C/zh not_active Expired - Fee Related
-
1999
- 1999-06-18 UY UY25575A patent/UY25575A1/es unknown
-
2000
- 2000-06-21 NO NO20003217A patent/NO316618B1/no unknown
- 2000-06-23 BG BG104554A patent/BG65024B1/bg unknown
-
2001
- 2001-07-27 HK HK01105260A patent/HK1034517A1/xx not_active IP Right Cessation
-
2005
- 2005-11-25 JP JP2005340586A patent/JP4411269B2/ja not_active Expired - Lifetime
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Legal Events
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GD4A | Issue of patent certificate for granted invention patent | ||
MM4A | Annulment or lapse of patent due to non-payment of fees |