TW239146B - - Google Patents

Info

Publication number
TW239146B
TW239146B TW082100298A TW82100298A TW239146B TW 239146 B TW239146 B TW 239146B TW 082100298 A TW082100298 A TW 082100298A TW 82100298 A TW82100298 A TW 82100298A TW 239146 B TW239146 B TW 239146B
Authority
TW
Taiwan
Prior art keywords
val
tyr
ser
lys
asp
Prior art date
Application number
TW082100298A
Other languages
English (en)
Original Assignee
Sclavo Biocine Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11361457&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW239146(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sclavo Biocine Spa filed Critical Sclavo Biocine Spa
Application granted granted Critical
Publication of TW239146B publication Critical patent/TW239146B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW082100298A 1991-12-31 1993-01-18 TW239146B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913513A IT1253009B (it) 1991-12-31 1991-12-31 Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini

Publications (1)

Publication Number Publication Date
TW239146B true TW239146B (zh) 1995-01-21

Family

ID=11361457

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082100298A TW239146B (zh) 1991-12-31 1993-01-18

Country Status (18)

Country Link
US (1) US6149919A (zh)
EP (3) EP1484404B1 (zh)
JP (2) JP3394774B2 (zh)
AT (3) ATE346932T1 (zh)
AU (1) AU3347693A (zh)
CA (1) CA2127091C (zh)
DE (3) DE69233667T2 (zh)
DK (3) DK0869181T3 (zh)
ES (3) ES2277195T3 (zh)
GR (1) GR3029556T3 (zh)
IT (1) IT1253009B (zh)
MX (1) MX9207685A (zh)
MY (1) MY108154A (zh)
PT (1) PT1484404E (zh)
SA (1) SA93130462B1 (zh)
SG (2) SG93200A1 (zh)
TW (1) TW239146B (zh)
WO (1) WO1993013202A1 (zh)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9513371D0 (en) 1995-06-30 1995-09-06 Biocine Spa Immunogenic detoxified mutant toxins
DK0725653T3 (da) 1993-10-05 2004-10-11 Celltech Pharmaceuticals Ltd Vaccinepræparater
GB9326174D0 (en) 1993-12-22 1994-02-23 Biocine Sclavo Mucosal adjuvant
US5981730A (en) * 1994-04-13 1999-11-09 The General Hospital Corporation RPS gene family, primers, probes, and detection methods
US6019982A (en) * 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant
US6436407B1 (en) 1994-08-26 2002-08-20 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic adjuvant
GB9603314D0 (en) * 1996-02-16 1996-04-17 Biocine Spa Immunogenic detoxified mutant toxins
GB9622660D0 (en) * 1996-10-31 1997-01-08 Biocine Spa Immunogenic detoxified mutant toxin
US20060002949A1 (en) 1996-11-14 2006-01-05 Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. Transcutaneous immunization without heterologous adjuvant
US6797276B1 (en) 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
AU7410798A (en) * 1996-11-29 1998-06-22 General Hospital Corporation, The Heterologous antigens in live cell V
WO1998032461A1 (en) * 1997-01-29 1998-07-30 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic adjuvant for hiv
EP1486215A3 (en) * 1997-03-21 2006-04-12 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US6818222B1 (en) * 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
EP0887403A3 (en) * 1997-06-27 2000-12-06 Chiron S.P.A. Attenuated Vibrio cholerae strains
AU9120898A (en) 1997-08-27 1999-03-16 Chiron Corporation Molecular mimetics of meningococcal b epitopes
WO1999047165A1 (en) * 1998-03-18 1999-09-23 The Administrators Of The Tulane Educational Fund Production of purified mutant enterotoxin for use as an adjuvant
US6033673A (en) * 1998-03-18 2000-03-07 The Administrators Of Tulane Educational Fund Double mutant enterotoxin for use as an adjuvant
WO1999065518A2 (en) 1998-06-19 1999-12-23 Merieux Oravax Lt and ct in parenteral immunization methods against helicobacter infection
DE19851282A1 (de) * 1998-11-06 2000-05-11 Schweiz Serum & Impfinst Zusammensetzung einer pharmazeutisch wirksamen Substanz, appliziert in einem spezifischen Delivery-System zur Prävention und Behandlung von Infektions-Krankheiten
BR9916515A (pt) * 1998-12-22 2001-11-06 Thompson Boyce Plant Res Polinucleotìdeo, vetor de expressão, células de e. coli e de agrobacterium tumefaciens transformadas com o vetor de expressão, célula de planta transgênica, semente de planta transgênica, célula eucariótica transgênica, composição imunogênica, método de evocar uma resposta imune em um animal ou ser humano, planta transgênica, e, adjuvante
CA2360347C (en) 1998-12-31 2013-05-07 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
US7935805B1 (en) 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
CA2363141C (en) 1999-02-26 2010-04-06 Chiron Corporation Microemulsions with adsorbed macromolecules and microparticles
ES2350306T3 (es) 1999-02-26 2011-01-20 Novartis Vaccines And Diagnostics, Inc. Uso de bioadhesivos y adyuvantes para la administración de antígenos por vía mucosa.
US7115730B1 (en) 1999-04-27 2006-10-03 Chiron Srl Immunogenic detoxified mutant E. coli LT-A-toxin
GB9919468D0 (en) 1999-08-17 1999-10-20 Smithkline Beecham Biolog Vaccine
AU5762299A (en) * 1999-09-15 2001-04-17 Mogam Biotechnology Research Institute Novel detoxified mutants of escherichia coli heat-labile enterotoxin
US7186560B2 (en) * 1999-09-21 2007-03-06 Rutgers, The State University Of New Jersey High level expression of immunogenic proteins in the plastids of higher plants
AU783800B2 (en) * 1999-09-21 2005-12-08 Rutgers, The State University Of New Jersey Site-specific recombination system to manipulate the plastid genome of higher plants
GB9923060D0 (en) 1999-09-29 1999-12-01 Chiron Spa Vaccine
US7384640B1 (en) 1999-09-30 2008-06-10 Wyeth Holdings Corporation Mutant cholera holotoxin as an adjuvant
DE60045516D1 (de) 1999-10-26 2011-02-24 Novartis Vaccines & Diagnostic Pflanzen lektine als mukosale adjuvantien
WO2001070257A1 (en) * 2000-03-17 2001-09-27 Uab Research Foundation Chimeric nontoxic mutants of enterotoxins as mucosal adjuvants for cell-mediated or humoral immunity
US7063852B2 (en) 2000-05-19 2006-06-20 The Administrators Of The Tulane Educational Fund Hybrid LT-A/CT-B holotoxin for use as an adjuvant
ES2397627T3 (es) 2000-12-07 2013-03-08 Novartis Vaccines And Diagnostics, Inc. Retrovirus endógenos regulados por aumento en el cáncer de próstata
EP2198882A3 (en) 2001-01-12 2010-10-13 Novartis Vaccines and Diagnostics, Inc. Nucleic acid mucosal immunization
EP2316482A1 (en) 2001-03-19 2011-05-04 Intercell USA, Inc. Transcutaneous immunostimulation
AU2002252525A1 (en) * 2001-03-29 2002-10-15 Rutgers, The University Of New Jersey Integrases for the insertion of heterologous nucleic acids into the plastid genome
EP1402075B1 (en) 2001-05-22 2012-11-14 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses
EP1404368B1 (en) 2001-06-07 2009-12-09 Wyeth Holdings Corporation Mutant forms of cholera holotoxin as an adjuvant
JP2005508143A (ja) * 2001-06-07 2005-03-31 ワイス・ホールデイングス・コーポレーシヨン アジュバントとしてのコレラホロトキシンの突然変異形
US8481043B2 (en) 2001-06-22 2013-07-09 Cpex Pharmaceuticals, Inc. Nasal immunization
AU2002320314A1 (en) 2001-07-05 2003-01-21 Chiron, Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
CA2452119C (en) 2001-07-05 2013-10-15 Chiron Corporation Polynucleotides encoding antigenic hiv type b and/or type c polypeptides, polypeptides and uses thereof
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
ES2615362T3 (es) 2001-07-27 2017-06-06 Glaxosmithkline Biologicals Sa Adhesinas de meningococos
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
ES2607431T3 (es) 2002-02-20 2017-03-31 Glaxosmithkline Biologicals Sa Micropartículas con moléculas que contienen polipéptidos adsorbidos
JP2005532789A (ja) 2002-03-15 2005-11-04 ワイス・ホールデイングス・コーポレーシヨン 減少した酵素活性を有する型別不能なインフルエンザ菌（Ｈａｅｍｏｐｈｉｌｕｓｉｎｆｌｕｅｎｚａ）のＰ４タンパク質の変異体
CA2489292A1 (en) 2002-06-13 2003-12-24 Chiron Corporation Vectors for expression of hml-2 polypeptides
US20040146533A1 (en) * 2002-08-27 2004-07-29 Miller Timothy J. Use of escherichia coli heat labile toxin as an adjuvant in birds and poultry
CN101721697A (zh) 2002-10-01 2010-06-09 诺华疫苗和诊断公司 抗癌及抗感染性疾病组合物及其使用方法
MXPA05004675A (es) 2002-11-01 2005-06-08 Glaxosmithkline Biolog Sa Proceso de secado.
EP1581256A4 (en) * 2002-11-14 2006-06-07 Pfizer Prod Inc USE OF RMLT AS MARKER ANTIGEN FOR VACCINE AND AS SYNERGISTIC ADJUVANS WITH AMPY
CA2511512C (en) 2002-12-27 2013-10-29 Chiron Corporation Immunogenic compositions containing phospholipid
US6743002B1 (en) * 2003-02-03 2004-06-01 Eaton Corporation Rotary fluid pressure device and improved integral brake assembly
AU2003274904A1 (en) * 2003-02-14 2004-09-09 Aeras Global Tuberculosis Vaccine Foundation Dna vaccine that expresses mutant adp-ribosyltransferase toxins which display reduced, or are devoid of, adp-ribosyltransferase activity
EP1606386A4 (en) * 2003-03-03 2007-07-18 Univ Rutgers REMOVAL OF PLASTIC SEQUENCES THROUGH TRANSIENT EXPRESSED LOCATION-SPECIFIC RECOMBINATION
US20060251675A1 (en) * 2003-03-17 2006-11-09 Michael Hagen Mutant cholera holotoxin as an adjuvant and an antigen carrier protein
GB0308198D0 (en) * 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
JP5557415B2 (ja) 2003-06-02 2014-07-23 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物
GB0313242D0 (en) * 2003-06-09 2003-07-16 Imp College Innovations Ltd Pulmonary immunopathology
AU2004268375B2 (en) 2003-09-02 2010-01-28 Glaxosmithkline Biologicals S.A. Vaccine
US20100015211A1 (en) 2004-11-01 2010-01-21 Barnett Susan W Combination Approaches For Generating Immune Responses
GB0503337D0 (en) 2005-02-17 2005-03-23 Glaxosmithkline Biolog Sa Compositions
EP1868645B1 (en) 2005-04-08 2012-03-07 Wyeth LLC Multivalent pneumococcal polysaccharide-protein conjugate composition
US20110223197A1 (en) 2005-10-18 2011-09-15 Novartis Vaccines And Diagnostics Inc. Mucosal and Systemic Immunization with Alphavirus Replicon Particles
US8143474B2 (en) * 2006-04-18 2012-03-27 Rutgers, The State University Of New Jersey Compositions and methods for increasing transgene expression in the plastids of higher plants
TW200806315A (en) 2006-04-26 2008-02-01 Wyeth Corp Novel formulations which stabilize and inhibit precipitation of immunogenic compositions
US8926993B2 (en) 2006-07-17 2015-01-06 Aduro Biotech Methods and compositions using Listeria for enhancing immunogenicity by prime boost
US8252897B2 (en) * 2007-06-21 2012-08-28 Angelica Therapeutics, Inc. Modified toxins
EP3067048B1 (en) 2007-12-07 2018-02-14 GlaxoSmithKline Biologicals SA Compositions for inducing immune responses
US8470314B2 (en) * 2008-02-29 2013-06-25 Angelica Therapeutics, Inc. Modified toxins
EP2293813A4 (en) 2008-05-23 2012-07-11 Univ Michigan NANOEMULSION VACCINES
US7914798B2 (en) 2008-06-20 2011-03-29 Wyeth Llc Compositions and methods of use of ORF1358 from beta-hemolytic streptococcal strains
WO2010036945A2 (en) 2008-09-26 2010-04-01 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
WO2010046783A2 (en) * 2008-10-21 2010-04-29 International Vaccine Institute A1 moiety of cholera toxin a subunit as an adjuvant for mucosal and systemic vaccines
WO2010078556A1 (en) 2009-01-05 2010-07-08 Epitogenesis Inc. Adjuvant compositions and methods of use
ES2593862T3 (es) 2009-03-09 2016-12-13 Molecular Express, Inc. Métodos y composiciones de formulación liposomal de antígenos y usos de los mismos
ES2566646T3 (es) 2009-06-16 2016-04-14 The Regents Of The University Of Michigan Vacunas en nanoemulsión
EP3461496B1 (en) 2009-06-22 2023-08-23 Wyeth LLC Compositions and methods for preparing staphylococcus aureus serotype 5 and 8 capsular polysaccharide conjugate immunogenic compositions
CN107096020A (zh) 2009-06-22 2017-08-29 惠氏有限责任公司 金黄色葡萄球菌抗原的免疫原性组合物
TW201103980A (en) 2009-07-08 2011-02-01 Abbott Biologicals Bv Viral vaccine and use thereof
US8241608B2 (en) * 2010-03-23 2012-08-14 Development Center For Biotechnology Treating allergy with detoxified E. coli heat-labile enterotoxin
US9161974B2 (en) 2010-05-23 2015-10-20 Aduro Biotech, Inc. Methods and compositions using listeria for adjuvant treatment of cancer
RU2607024C2 (ru) 2010-06-04 2017-01-10 УАЙТ ЭлЭлСи Вакцины streptococcus pneumoniae
US8658603B2 (en) 2010-06-16 2014-02-25 The Regents Of The University Of Michigan Compositions and methods for inducing an immune response
DK2608805T3 (en) 2010-08-23 2017-08-14 Wyeth Llc STABLE FORMULATIONS OF NEISSERIA MENINGITIDIS rLP2086 ANTIGENES
EP3056212B1 (en) 2010-09-10 2019-04-03 Wyeth LLC Non-lipidated variants of neisseria meningitidis orf2086 antigens
CN103826656B (zh) 2010-12-22 2015-08-26 惠氏有限责任公司 金黄色葡萄球菌抗原的稳定的免疫原性组合物
EP2701734B1 (en) 2011-04-26 2019-09-25 Molecular Express, Inc. Liposomal formulations
EP2723378A4 (en) 2011-06-24 2015-01-28 Epitogenesis Inc PHARMACEUTICAL COMPOSITIONS COMPRISING A COMBINATION OF VECTORS, VITAMINS, TANNINS AND FLAVONOIDS SELECTED AS ANTIGEN-SPECIFIC IMMUNOMODULATORS
RU2014124154A (ru) 2011-11-14 2015-12-27 Новартис Аг Иммуногенные комплексы полианионных карбомеров и полипептидов env и способы их получения и применения
CA2865745C (en) 2012-03-09 2018-01-09 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
SA115360586B1 (ar) 2012-03-09 2017-04-12 فايزر انك تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
EP3608401A1 (en) 2012-07-05 2020-02-12 Ohio State Innovation Foundation Compositions and methods related to viral vaccines
WO2014044690A1 (en) 2012-09-18 2014-03-27 Valneva Austria Gmbh Improved vaccines
KR101819803B1 (ko) 2012-10-24 2018-01-17 플레이틀렛 타게티드 테라퓨틱스, 엘엘씨 혈소판 표적화 치료
DK2935299T3 (da) 2012-12-20 2019-11-18 Pfizer Glycokonjugationsfremgangsmåde
TR201807340T4 (tr) 2013-02-01 2018-06-21 Glaxosmithkline Biologicals Sa Çan benzeri reseptör agonistleri içeren immünolojik kompozisyonların intradermal yoldan verilmesi.
ES2685894T3 (es) 2013-03-08 2018-10-15 Pfizer Inc. Polipéptidos de fusión inmunogénicos
EP2968450A4 (en) 2013-03-15 2016-10-26 Angelica Therapeutics Inc MODIFIED TOXINS
EP3041502A2 (en) 2013-09-08 2016-07-13 Pfizer Inc. Neisseria meningitidis compositions and methods thereof
CN105992770B (zh) 2013-11-01 2021-06-25 奥斯陆大学 白蛋白的变体及其用途
WO2015071769A2 (en) 2013-11-13 2015-05-21 University Of Oslo Outer membrane vesicles and uses thereof
US11452767B2 (en) 2013-11-15 2022-09-27 Oslo Universitetssykehus Hf CTL peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof
WO2016130569A1 (en) 2015-02-09 2016-08-18 Mj Biologics, Inc. A composition comprising pedv antigens and methods for making and using the composition
WO2015138455A1 (en) 2014-03-11 2015-09-17 Regents Of The University Of Minnesota Porcine epidemic diarrhea virus vaccines and methods of use thereof
EP3204039B1 (en) 2014-10-10 2022-06-08 The Regents Of The University Of Michigan Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease
RU2723045C2 (ru) 2015-02-19 2020-06-08 Пфайзер Инк. Композиции neisseria meningitidis и способы их получения
EP4226937A3 (en) 2015-03-05 2023-09-27 Northwestern University Non-neuroinvasive viruses and uses thereof
US10624964B2 (en) 2015-05-01 2020-04-21 The Trustees Of The University Of Pennsylvania Methods and compositions for stimulating immune response using potent immunostimulatory RNA motifs
CN114010775A (zh) 2015-05-04 2022-02-08 辉瑞大药厂 B族链球菌多糖-蛋白质缀合物、制造缀合物的方法、含缀合物的免疫原性组合物及其用途
CN108348593B (zh) 2015-08-31 2022-08-16 泰克诺瓦克斯股份有限公司 基于人呼吸道合胞病毒(hrsv)病毒样颗粒(vlps)的疫苗
US10548970B2 (en) 2015-10-05 2020-02-04 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Human rotavirus G9P[6] strain and use as a vaccine
WO2017158421A1 (en) 2016-03-14 2017-09-21 University Of Oslo Anti-viral engineered immunoglobulins
KR20230062894A (ko) 2016-03-14 2023-05-09 유니버시티에트 이 오슬로 변경된 FcRn 결합을 갖는 조작된 면역글로불린
US11173207B2 (en) 2016-05-19 2021-11-16 The Regents Of The University Of Michigan Adjuvant compositions
WO2017210215A1 (en) 2016-05-31 2017-12-07 The Government Of The United States Of America As Represented By The Secretary Of The Army Zika virus vaccine and methods of production
EP3471761A2 (en) 2016-06-21 2019-04-24 University Of Oslo Hla binding vaccine moieties and uses thereof
GB201614799D0 (en) 2016-09-01 2016-10-19 Glaxosmithkline Biologicals Sa Compositions
US10751402B2 (en) 2016-11-09 2020-08-25 Pfizer Inc. Immunogenic compositions and uses thereof
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
KR102567845B1 (ko) 2017-01-31 2023-08-17 화이자 인코포레이티드 네이세리아 메닌기티디스 조성물 및 그의 방법
US10525119B2 (en) 2017-03-31 2020-01-07 Boston Medical Center Corporation Methods and compositions using highly conserved pneumococcal surface proteins
EP3678699A1 (en) 2017-09-07 2020-07-15 University Of Oslo Vaccine molecules
JP2020533338A (ja) 2017-09-07 2020-11-19 ユニバーシティ オブ オスロＵｎｉｖｅｒｓｉｔｙ ｏｆ Ｏｓｌｏ ワクチン分子
CA3165957A1 (en) 2020-01-24 2021-07-29 Thomas K. EQUELS Methods, compositions, and vaccines for treating a virus infection
WO2021211279A1 (en) 2020-04-17 2021-10-21 Regents Of The University Of Minnesota SARS-CoV-2 SPIKE RECEPTOR BINDING DOMAIN AND COMPOSITIONS AND METHODS THEREOF
US20230321212A1 (en) 2020-08-26 2023-10-12 Pfizer Inc. Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof
EP4313132A1 (en) 2021-03-31 2024-02-07 Vib Vzw Vaccine compositions for trypanosomatids
CN113788893B (zh) * 2021-08-11 2022-08-09 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) 一种快速富集霍乱弧菌的偶联特异性单克隆抗体的免疫磁珠及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666837A (en) * 1982-05-24 1987-05-19 Smithkline-Rit DNA sequences, recombinant DNA molecules and processes for producing the A and B subunits of cholera toxin and preparations containing so-obtained subunit or subunits
US4935364A (en) * 1983-03-04 1990-06-19 Swiss Serum And Vaccine Institute Berne Method of isolating restriction fragment deletions in vibrio cholerae and products thereof
GB8333131D0 (en) * 1983-12-12 1984-01-18 Glaxo Group Ltd Microbiological process
IL101715A (en) * 1991-05-02 2005-06-19 Amgen Inc Recombinant dna-derived cholera toxin subunit analogs

Also Published As

Publication number Publication date
EP0620850A1 (en) 1994-10-26
ATE177145T1 (de) 1999-03-15
DK1484404T3 (da) 2007-03-19
DK0869181T3 (da) 2005-01-31
ATE277183T1 (de) 2004-10-15
US6149919A (en) 2000-11-21
CA2127091C (en) 2000-08-01
EP1484404B1 (en) 2006-11-29
CA2127091A1 (en) 1993-07-08
PT1484404E (pt) 2007-03-30
EP0869181B1 (en) 2004-09-22
JP3394774B2 (ja) 2003-04-07
ATE346932T1 (de) 2006-12-15
GR3029556T3 (en) 1999-06-30
ITMI913513A1 (it) 1993-07-01
DE69233667T2 (de) 2007-09-27
AU3347693A (en) 1993-07-28
JPH07506240A (ja) 1995-07-13
IT1253009B (it) 1995-07-10
DE69233417D1 (de) 2004-10-28
DE69233667D1 (de) 2007-01-11
ITMI913513A0 (it) 1991-12-31
DE69233417T2 (de) 2005-09-29
WO1993013202A1 (en) 1993-07-08
MX9207685A (es) 1994-05-31
EP0620850B1 (en) 1999-03-03
EP0869181A1 (en) 1998-10-07
MY108154A (en) 1996-08-30
ES2127808T3 (es) 1999-05-01
ES2277195T3 (es) 2007-07-01
JP2003000287A (ja) 2003-01-07
DE69228563T2 (de) 1999-07-29
EP1484404A1 (en) 2004-12-08
ES2227762T3 (es) 2005-04-01
SG48217A1 (en) 1998-04-17
DE69228563D1 (de) 1999-04-08
JP3408529B2 (ja) 2003-05-19
DK0620850T3 (da) 1999-09-27
SA93130462B1 (ar) 2004-09-01
SG93200A1 (en) 2002-12-17

Similar Documents

Publication Publication Date Title
TW239146B (zh)
DE69636735D1 (de) Immunogene, ungiftige choleratoxinmutante
GB9622660D0 (en) Immunogenic detoxified mutant toxin
DK213784D0 (da) Ikke-toxinogene vibrio choleraemutanter
IL68790A (en) Polydeoxyribonucleotide coding for ifn-alpha2(arg),plasmid containing it,cloning of said plasmid and microorganisms containing it and ifn-alpha(arg)encoded by said polydeoxyribonucleotide and its preparation
Dertzbaugh et al. Reduction in oral immunogenicity of cholera toxin B subunit by N-terminal peptide addition
CA2154063A1 (en) Treatment of h. pylori associated gastroduodenal disease
WO2000037609A3 (en) Orally immunogenic bacterial enterotoxins expressed in transgenic plants
Magagnoli et al. Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin
ES477212A1 (es) Un procedimiento para la preparacion de una enterotoxina.
JP4599354B2 (ja) 大腸菌熱不安定性エンテロトキシンサブユニットに融合した志賀毒素サブユニットまたは志賀毒素様毒素サブユニットを含むハイブリッド毒素およびそのワクチン
FI891832A (fi) Specialmutant av escherichia coli.
IE851710L (en) Production of a polypeptide
CA2219943A1 (en) Hybrid molecules between heat-labile enterotoxin and cholera toxin b subunits
IE894177L (en) Plasmids with a translation start-stop-start codon¹configuration for the expression of proteins in E. coli
DK158033C (da) Fremgangsmaade til afgiftning af e.coli neurotoxin og fremgangsmaade til fremstilling af en vaccine mod oedemsygdom hos smaagrise
IT1190884B (it) Composizione di un immunogeno per la protezione contro la diarrea provocata da escherichia coli enterotossinogena