TW202208431A - ＳＩＲＰα及ＳＩＲＰβ１抗體及其用途 - Google Patents
ＳＩＲＰα及ＳＩＲＰβ１抗體及其用途 Download PDFInfo
- Publication number
- TW202208431A TW202208431A TW110116828A TW110116828A TW202208431A TW 202208431 A TW202208431 A TW 202208431A TW 110116828 A TW110116828 A TW 110116828A TW 110116828 A TW110116828 A TW 110116828A TW 202208431 A TW202208431 A TW 202208431A
- Authority
- TW
- Taiwan
- Prior art keywords
- seq
- antibody
- acid sequence
- cells
- sirpα
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063022309P | 2020-05-08 | 2020-05-08 | |
| US63/022,309 | 2020-05-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202208431A true TW202208431A (zh) | 2022-03-01 |
Family
ID=76197640
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110116828A TW202208431A (zh) | 2020-05-08 | 2021-05-10 | ＳＩＲＰα及ＳＩＲＰβ１抗體及其用途 |
| TW110116827A TW202208430A (zh) | 2020-05-08 | 2021-05-10 | ＳＩＲＰα、ＳＩＲＰβ１及ＳＩＲＰγ抗體及其用途 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110116827A TW202208430A (zh) | 2020-05-08 | 2021-05-10 | ＳＩＲＰα、ＳＩＲＰβ１及ＳＩＲＰγ抗體及其用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US12503508B2 (https=) |
| EP (2) | EP4146698A1 (https=) |
| JP (2) | JP2023525753A (https=) |
| KR (2) | KR20230017219A (https=) |
| CN (2) | CN115768795A (https=) |
| AU (2) | AU2021267943A1 (https=) |
| CA (2) | CA3177961A1 (https=) |
| GB (2) | GB2613259A (https=) |
| IL (2) | IL298024A (https=) |
| TW (2) | TW202208431A (https=) |
| WO (2) | WO2021226591A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021226591A1 (en) | 2020-05-08 | 2021-11-11 | Electra Therapeutics, Inc. | Sirp alpha, sirp beta 1, and sirp gamma antibodies and uses thereof |
| CN118591619A (zh) * | 2021-11-24 | 2024-09-03 | 雷格细胞股份有限公司 | 人诱导性调节性t细胞及其制作方法 |
| EP4619435A1 (en) | 2022-11-16 | 2025-09-24 | Boehringer Ingelheim International GmbH | Predictive efficacy biomarkers for anti-sirpa antibodies |
| CN117025547B (zh) * | 2023-10-08 | 2023-12-12 | 迈杰转化医学研究(苏州)有限公司 | 产生抗b7h3单克隆抗体的杂交瘤细胞株及其应用 |
| TW202529810A (zh) | 2023-10-19 | 2025-08-01 | 美商電子療法股份有限公司 | 用於治療噬血球性淋巴組織細胞增生症之ｓｉｒｐ抗體 |
| TW202523701A (zh) | 2023-10-19 | 2025-06-16 | 美商電子療法股份有限公司 | 用於治療癌症之ｓｉｒｐ抗體 |
| WO2025226691A1 (en) | 2024-04-22 | 2025-10-30 | Electra Therapeutics, Inc. | Sirp alpha and beta antibodies for treatment of epstein–barr virus infections |
| CN119192379B (zh) * | 2024-11-22 | 2025-01-28 | 四川省医学科学院·四川省人民医院 | 一种具有高亲和力的抗SIRPγ单克隆抗体及其用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015229448B2 (en) * | 2014-03-11 | 2020-09-03 | The Board Of Trustees Of The Leland Stanford Junior University | Anti SIRP-alpha antibodies and Bi-specific Macrophage Enhancing antibodies |
| KR20260030924A (ko) * | 2016-08-09 | 2026-03-06 | 키맵 리미티드 | 항-icos 항체 |
| CN118027200A (zh) | 2016-12-09 | 2024-05-14 | 艾利妥 | 抗SIRPα抗体及其使用方法 |
| MA47111A (fr) | 2016-12-22 | 2019-10-30 | Univ Wake Forest Health Sciences | Agents ciblant sirpgamma destinés à être utilisés dans le traitement du cancer |
| JP7179743B2 (ja) * | 2017-02-17 | 2022-11-29 | オーエスイー・イミュノセラピューティクス | 抗ＳＩＲＰｇ抗体の新規の使用 |
| CN118267470A (zh) | 2017-04-13 | 2024-07-02 | 赛罗帕私人有限公司 | 抗SIRPα抗体 |
| CN118271443A (zh) * | 2017-05-16 | 2024-07-02 | 拜奥迪斯私人有限公司 | 抗SIRPα抗体 |
| JP7395471B2 (ja) * | 2017-10-13 | 2023-12-11 | オーセ イミュノセラピューティクス | 改変抗ＳＩＲＰａ抗体及びその使用 |
| EP3802602A1 (en) * | 2018-05-25 | 2021-04-14 | Alector LLC | Anti-sirpa antibodies and methods of use thereof |
| CA3140904A1 (en) | 2019-06-24 | 2020-12-30 | Amgen Inc. | Inhibition of sirp-gamma for cancer treatment |
| US20230340112A1 (en) | 2020-02-28 | 2023-10-26 | Apexigen, Inc. | Anti-sirpa antibodies and methods of use |
| WO2021226591A1 (en) * | 2020-05-08 | 2021-11-11 | Electra Therapeutics, Inc. | Sirp alpha, sirp beta 1, and sirp gamma antibodies and uses thereof |
| WO2023086906A2 (en) | 2021-11-10 | 2023-05-19 | Electra Therapeutics, Inc. | Sirp gamma antibodies and uses thereof |
| TW202523701A (zh) | 2023-10-19 | 2025-06-16 | 美商電子療法股份有限公司 | 用於治療癌症之ｓｉｒｐ抗體 |
| TW202529810A (zh) | 2023-10-19 | 2025-08-01 | 美商電子療法股份有限公司 | 用於治療噬血球性淋巴組織細胞增生症之ｓｉｒｐ抗體 |
-
2021
- 2021-05-10 WO PCT/US2021/031605 patent/WO2021226591A1/en not_active Ceased
- 2021-05-10 EP EP21729164.0A patent/EP4146698A1/en active Pending
- 2021-05-10 IL IL298024A patent/IL298024A/en unknown
- 2021-05-10 EP EP21730008.6A patent/EP4146699A1/en active Pending
- 2021-05-10 CN CN202180033618.6A patent/CN115768795A/zh active Pending
- 2021-05-10 GB GB2218419.6A patent/GB2613259A/en not_active Withdrawn
- 2021-05-10 AU AU2021267943A patent/AU2021267943A1/en active Pending
- 2021-05-10 CN CN202180033623.7A patent/CN115768796A/zh active Pending
- 2021-05-10 JP JP2022567870A patent/JP2023525753A/ja active Pending
- 2021-05-10 KR KR1020227042951A patent/KR20230017219A/ko active Pending
- 2021-05-10 IL IL297982A patent/IL297982A/en unknown
- 2021-05-10 TW TW110116828A patent/TW202208431A/zh unknown
- 2021-05-10 US US17/923,778 patent/US12503508B2/en active Active
- 2021-05-10 CA CA3177961A patent/CA3177961A1/en active Pending
- 2021-05-10 WO PCT/US2021/031541 patent/WO2021226576A1/en not_active Ceased
- 2021-05-10 CA CA3178038A patent/CA3178038A1/en active Pending
- 2021-05-10 TW TW110116827A patent/TW202208430A/zh unknown
- 2021-05-10 GB GB2218421.2A patent/GB2613464A/en not_active Withdrawn
- 2021-05-10 KR KR1020227042887A patent/KR20230017793A/ko active Pending
- 2021-05-10 US US17/923,781 patent/US20230174648A1/en active Pending
- 2021-05-10 AU AU2021269130A patent/AU2021269130A1/en active Pending
- 2021-05-10 JP JP2022567837A patent/JP2023525298A/ja active Pending
-
2024
- 2024-02-28 US US18/590,865 patent/US12187797B2/en active Active
- 2024-11-27 US US18/963,213 patent/US20250197492A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20250197492A1 (en) | 2025-06-19 |
| KR20230017793A (ko) | 2023-02-06 |
| GB202218421D0 (en) | 2023-01-18 |
| JP2023525753A (ja) | 2023-06-19 |
| GB2613464A (en) | 2023-06-07 |
| AU2021269130A1 (en) | 2022-11-24 |
| JP2023525298A (ja) | 2023-06-15 |
| GB2613259A (en) | 2023-05-31 |
| EP4146699A1 (en) | 2023-03-15 |
| US12503508B2 (en) | 2025-12-23 |
| GB202218419D0 (en) | 2023-01-18 |
| US12187797B2 (en) | 2025-01-07 |
| US20230303685A1 (en) | 2023-09-28 |
| US20240239888A1 (en) | 2024-07-18 |
| CN115768795A (zh) | 2023-03-07 |
| KR20230017219A (ko) | 2023-02-03 |
| WO2021226591A1 (en) | 2021-11-11 |
| EP4146698A1 (en) | 2023-03-15 |
| WO2021226576A1 (en) | 2021-11-11 |
| IL297982A (en) | 2023-01-01 |
| CA3178038A1 (en) | 2021-11-11 |
| TW202208430A (zh) | 2022-03-01 |
| CA3177961A1 (en) | 2021-11-11 |
| IL298024A (en) | 2023-01-01 |
| CN115768796A (zh) | 2023-03-07 |
| AU2021267943A1 (en) | 2022-11-24 |
| US20230174648A1 (en) | 2023-06-08 |
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