TW200300069A - Anti-obesity foods and drinks - Google Patents

Abstract

Anti-obesity foods and drinks containing compounds selected from the group consisting of pentacyclic triterpenes, physiologically acceptable salts thereof and derivatives of the same, in particular, anti-obesity foods and drinks containing maslinic acid and/or physiologically acceptable salts thereof.

Description

200300069 A7 B7 V. Description of the invention (j) Background of the invention (please read the notes on the back before filling out this page) Printed by Xiao Gong Consumer Cooperative, Bureau of Intellectual Property, Ministry of Economic Affairs Anti-fullness is related to coriander food. Recently, the Japanese people ’s food life has become significantly higher in Europe and the United States. As a result, the so-called overcrowding phenomenon of civilization disease caused by modern people has led to an increase in the incidence of various diseases such as diabetes, hypertension, cardiovascular disease, hyperlipidemia, and arteriosclerosis, which has become a serious society threatening national health problem. In addition, recently Japanese people, especially women, have a high desire for thinness and slimness due to the aesthetic ideology. Obesity is a physical condition in which the intake of calories is higher than the calories consumed, causing fat tissue to accumulate differently than usual. Adipose tissue is an organ that accumulates excess heat in the body as fat. It is composed of fat cells or their precursor cells, macrophages, peripheral blood vessels, blood cells, and so on. Adipocytes are differentiated (differentiation induced) from their precursor cells by ingestion of many factors derived from environmental factors such as food or exercise into mature adipocytes (mature adipocytes), cells that can accumulate fat in cells. In addition, it is also known that precursor adipocytes (ie, adipocyte precursor cells) or the adipocytes themselves increase their number of cells by repeated cell division (see Sugihara et al .; separate volume, advances in medicine, adipocytes, basic and clinical, 7-12 P. 1,999). The main reasons for the increase in adipose tissue are the increase in the size of adipocytes (ie, hypertrophic hypertrophy), the increase in the number of adipocytes (ie, hypertrophic hypertrophy), or the increase of the two (ie, hypertrophy, formativeness). Too big plump). Hypertrophic obesity is usually called middle-aged obesity and is usually seen in obese people after middle age. Formal hypertrophy is more common in obese people from an early age. In particular, the latter who are over-formed and obese are obese during growth, so the increase in the number of fat cells by 2 to 3 times is the main reason. This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -5- 200300069 A7 B7 V. Description of the invention (2) (Please read the notes on the back before filling out this page) After this increased fat cells become adults, the fat cells will become smaller when they lose weight, but the number of fat cells will not decrease. Therefore, a little overeating will cause the fat to accumulate easily due to the large number of fat cells, which will cause the body to become full. Therefore, although there have been various proposals for measures such as measures for obesity and weight loss, but looking at the current situation, only surgical methods such as liposuction can really achieve satisfactory results. However, the use of this surgical treatment method on human or animal body cannot be said to be a non-dangerous invasive operation. Moreover, the cost of the operation is obviously disadvantageous. On the one hand, pentacyclic triterpenes are compounds of pentacyclic structure formed by 6 isoprene units, usually with 30 carbons as the basic Structure, but the carbon number is increased or decreased due to metastasis, oxidation, detachment or alkylation during the process of biogenic formation. Those whose functions are known have anti-inflammatory function, anti-oncogenic promoter function # ( (Refer to the Japan Oil Chemistry Conference, 49, 571, 2000). However, pentacyclic triterpenes and their physiologically acceptable salts or their derivatives have been completely unknown in the past as having a precursor-type adipocyte proliferation inhibitory function (adipocytes) Antiproliferative function), precursor type adipocyte differentiation inhibition function (adipocyte differentiation induction function), mature adipocyte fat accumulation inhibition function (adipocyte maturation inhibition function) and other anti-fullness functions, and these effects are taken orally The pentacyclic triterpenes and their physiologically acceptable salts or their derivatives can be fully expressed. DISCLOSURE OF THE INVENTION The object of the present invention is to provide a hypertrophic, plump, and shaped The size of the paper that is too big and full is applicable to the Chinese National Standard (CN'S) A4 specification (210 father 297 mm 1 " -6- 200300069 A7 B7 V. Invention Description (3) (Please read the notes on the back before filling (This page), preventive and / or ameliorating hypertrophy, such as hypertrophy, hypertrophy, etc., and anti-fertility that is continuous, simple, and very effective for the purpose of reducing weight or making it difficult for obesity. Foods full of coriander. The present inventors worked hard to achieve the above-mentioned object and found out that pentacyclic triterpenes and their physiologically acceptable salts or derivatives thereof have a precursor-type adipocyte proliferation inhibiting function, a precursor-type adipocyte Inhibition function, mature fat cell fat accumulation inhibition function, etc. have excellent functions for improving plumpness, and oral penetrating of the pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof can be fully achieved In other words, the present invention contains one or two selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. Those who are related to anti-fatness are related to glutinous food. Since its form belongs to glutinous food, it can be easily and continuously ingested. As a result, excellent anti-fullness function can be expected. Printed by Xiao Gong Consumer Cooperative, Intellectual Property Bureau, Ministry of Economic Affairs ¾ In addition, The present invention also contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof as a precursor type fat cell proliferation inhibitory component, and precursor type fat cells Differentiation-inhibiting ingredients, mature fat cell fat accumulation inhibiting ingredients are related to anti-plump foods. Because their form belongs to foods, they can be easily and continuously ingested. As a result, they can be expected to have an excellent effect of inhibiting the proliferation of precursor adipocytes. The progenitor-type adipocyte generation inhibition effect and the mature-type adipocyte accumulation inhibition effect. In addition, the present invention is also the above-mentioned pentacyclic triterpene system consisting of oleanole-based triterpene and ursane-based triterpene 1 and 3 of the lupinane triterpenes are selected from the & Zhang scale applicable to the Chinese National Standard (CNS) A4 specifications (210X 297 mm j " 200300069 A7 B7__ V. The invention (4) (Please read the precautions on the back before filling out this page). The oleanolic triterpenes are preferably maslinic acid and / or cocadiol, and more particularly maslinic acid. Ursolic triterpenes are preferably ursolic acid and / or ursitol, and lupines triterpenes are betulinic acid and / or betulin. The pentacyclic triterpenes and their physiologically acceptable salts or their derivatives in the present invention can be applied regardless of whether they are derived from natural or artificial synthesis. The medium extraction is suitable, and the concentration and / or separation is also preferable, and the refinement is also preferable, especially the separation, and the refinement is more preferable. The present invention relates to a fat-reducing food containing an olive oil plant defatted product, an olive oil extract or an olive oil extract as an effective ingredient. Among them, the olive oil plant extract is preferably an extract obtained by extracting the defatted product obtained from the olive oil manufacturing process with water and / or an organic solvent. Printed by the Industrial and Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ¾ Hawthorn acid and / or physiologically acceptable salts thereof are preferably obtained from olives, hops, mint, pomegranate, cloves, sage or dates. The byproducts of olive olive plants and / or olive oil manufacturing processes are extracted and treated with water and / or organic solvents, and then concentrated and / or separated, and refined, preferably those obtained by isolation and purification. At this time, when the present invention is a glutinous food, the organic solvent used in the extraction treatment is preferably a hydrophilic organic solvent, of which alcohols are more preferred, and ethanol is particularly preferred. Especially the slag acid and / Or its physiologically acceptable salts are natural in nature, and are very advantageous in terms of post-price and manufacturing efficiency. The form of the anti-fattiness foods for use in the present invention, such as candy, processed foods, oils and fats, seasonings, dairy products, foods, etc., whose shape and properties are in accordance with the paper standard and suitable for household materials (CNS). 21 () > < 297 public directors " -8- 200300069 A7 _ B7 V. Description of the invention (5) There is no particular limitation, and it can be any of solid, semi-solid, gel, liquid, and powder Etc. Also, any dosage form such as lozenge, capsule, liquid, granule can be used. The aforementioned pentacyclic triterpenes and / or specific derivatives thereof are generally oil-soluble. Therefore, the fat-repellent food product of the present invention is preferably in the form of fats and oils and / or processed oils. It is more preferable to use the fat and / or processed fat product as a raw material, or to deep-fry or stir-fry ravioli. In addition, the fermented food for preventing fullness of the present invention may be a water-based fermented material such as a fermented material. In particular, part or all of the pentacyclic triterpenes are made into physiologically acceptable salts and / or specific derivatives thereof, and the oil-soluble pentacyclic triterpenes can be used as water-soluble. In addition, the present invention also relates to a group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof, in which one or two or more are selected for anti-hypertrophy and / or excessive formation. Those who use plump food. In addition, the present invention also contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof, for preventing obesity and / or treating obesity foods for obesity. . In addition, the present invention also contains pentacyclic triterpenes, and one or two or more weight loss foods selected from the group consisting of physiologically acceptable salts or derivatives thereof. In addition, the present invention also contains pentacyclic triterpenes and a physiologically acceptable salt or a derivative thereof, which is selected from one or two or more types of non-fertile foods for improving physical fitness. This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) (Please read the precautions on the back before filling out this page) π Pack. Order for Economics and Intellectual Property Bureau a (Industrial Consumer Goods Cooperatives ^ -9- 200300069 A7 B7 V. Description of the invention (6) ^ Apply the best form of the invention (please read the notes on the back before filling this page) The invention contains pentacyclic triterpenes and their physiologically acceptable salts One or two or more of these derivatives are selected to form an anti-fattiness glutinous food. The present invention belongs to the form of glutinous food, so it can be conveniently and continuously ingested with excellent anti-fullness function. The pentacyclic property Triterpenes refer to pentacyclic compounds in triterpenes composed of 6 isoprene units. They exist in various plants in nature and there are many substance groups. These substances can be obtained from natural plants. Extracted, some of which have been artificially synthesized for testing and other marketers can provide the invention. Printed by the Consumers' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ¾ Containing the above substances means containing water that can exert anti-fullness functions, etc. Meaning, but its content is not particularly limited, and may be moderate depending on the type of pentacyclic triterpene, the type of food, intake, frequency, age, gender, weight, severity of symptoms, health status, etc. Adjust it. For example, the content is in the range of 0.00001 to 90% by mass, of which 0.0001 to 80% by mass. / Is suitable, preferably 0.001 to 70% by mass, and more preferably 0.01 to 65% by mass, more It is preferably 0.1 to 60% by mass, more preferably 0.2 to 55% by mass, more preferably 0.4 to 50% by mass, still more preferably 0.6 to 45% by mass, and still more preferably 0.8 to 40% by mass. More preferably, it is more preferably 1.0 to 35% by mass, and more preferably 2.0 to 30% by mass, but it is not limited to the above range. In addition, the present invention also contains pentacyclic triterpenes and their physiology. For permissible salts, one or two or more of its derivatives are selected as precursor-type adipocyte proliferation inhibiting ingredients, precursor-type adipocyte differentiation inhibiting ingredients, and mature adipocyte fat accumulation inhibiting ingredients for anti-puffiness.飮 Food related. The above as a precursor type of fat cell proliferation Inhibitory ingredients, precursor type fat cells. Paper scale is applicable to Chinese National Standard (CNS) A4 specification (210X297 mm) -10- 200300069 A7 B7 V. Description of invention (7) (Please read the precautions on the back before filling this page) The inclusion of differentiation inhibiting components and mature fat cell fat accumulation inhibiting components means that they can exert the precursor adipocyte proliferation inhibiting function, precursor adipocyte differentiation inhibiting function, and mature adipocyte fat accumulating inhibiting functions. Its content is not particularly limited, and it is appropriately adjusted according to the type of pentacyclic triterpene contained, the type of food, intake, frequency, age, gender, weight, severity of symptoms, and health status. Its content is, for example, in the range of 0.0001 to 90% by mass, of which 0.0001 to 80% by mass is preferable, 0.001 to 70% by mass is more preferable, and 0.001 to 65% by mass is more preferable, and 0.1 to 60% is more preferable. Mass% is better, more preferably 0.2 to 55 mass%, more preferably 0.4 to 50 mass%, still more preferably 0.6 to 45 mass%, and still more preferably 0.8 to 40 mass%, It is more preferably 1.0 to 35% by mass, and more preferably 2.0 to 30% by mass, but is not limited to the above range. Those with a precursor-type adipocyte proliferation inhibition function, a precursor-type adipocyte differentiation inhibition function, and a mature adipocyte fat accumulation inhibition function. Among the pentacyclic triterpenes, oleanolane-type triterpenes and bear fruit Alkane triterpenes and lupinane triterpenes are more preferred, and the present invention contains those selected from the above-mentioned selection of one or two or more kinds of anti-fertility foods. Consumption cooperation between employees of the Intellectual Property Bureau of the Ministry of Economic Affairs and Fibonacci ¾ The oleanolic triterpenes are preferably maslinic acid and / or cocadiol, especially maslinic acid. Ursolic acid triterpenes are preferably ursolic acid and / or arsanol. Lupinic triterpenes are preferably betulinic acid and / or betulin. The above compounds have a function of inhibiting proliferative adipocyte proliferation, inhibiting proliferative adipocyte differentiation, and inhibiting fat accumulation in mature adipocytes. This function can be evaluated by the culture cell test method. This paper is applicable to China. Sample standard (CNS) A4 is now (210X297 mm) -11- 200300069 A7 _ _B7_ V. Description of the invention (8) (Please read the precautions on the back before filling this page). According to this evaluation method, compared with the conjugated linoleic acid (CLA) of a known substance that has a strong anti-fullness function, it is known that it has an anti-fullness function of 2 to 60 times. As for the function of continuous ingestion, it was also found that when it was taken orally through animal experiments, it fully exhibited its anti-puffiness function. The pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof in the present invention can be obtained from nature, or can be artificially synthesized, both of which are applicable, but it is considered that the present invention belongs to coriander food In terms of form, it is preferable to extract from natural raw materials. Among them, it is better to concentrate and / or separate, and the refiner is the best, especially to isolate and refine. Printed by the Industrial and Commercial Consumer Cooperative of the Intellectual Property Office of the Ministry of Economic Affairs ¾ Hawthorn acid and / or physiologically acceptable salts thereof are preferably obtained from olive, hops, pomegranate, clove, sage or date The olive oil plant and / or the olive oil manufacturing process by-products obtained from the by-products are subjected to extraction treatment with water and / or organic solvents, followed by concentration treatment and / or separation, and refinement treatment is better, especially separation and purification is the best. In this case, considering that the present invention belongs to the form of glutinous food, the organic solvent used in the extraction treatment is preferably a hydrophilic organic solvent, among which alcohols are more preferred, and ethanol is particularly preferred. In particular, maslinic acid and / or physiologically acceptable salts thereof obtained from olive olive plants are natural substances, and are particularly preferable in terms of price, manufacturing efficiency, and the like. The form of the loquat food in the present invention is as described above. For example, various loquat foods such as sugar chestnuts, processed foods, oils, seasonings, dairy products, and seasonings are all included. There is no particular limitation on the shape and properties of the products. It can be solid, semi-solid, gel, liquid, powder, etc., and can be any dosage form such as lozenge, capsule, liquid, granule. The paper size for anti-fattiness for the present invention ^ The paper size applies to the Chinese National Standard (CNS) A4 specification (210X297 mm) -12- 200300069 A7 B7 V. Description of the invention (9) (Please read the precautions on the back before filling in this Page), because the pentacyclic triterpenes and / or their specific derivatives are mostly oil-soluble. Therefore, when 飮 foods are fats and / or processed fats and oils, they can be said to be in the best form. For example, it contains high amounts of maslinic acid oil, but it is not limited to this exemplified range. In addition, it is more preferable to use the fat and / or processed fat product as a raw material, or to obtain food by frying or frying. In addition, the fermented foods for preventing fullness of the present invention may be water-based foods such as foods. In particular, making one or all of the pentacyclic triterpenes into a physiologically acceptable salt and / or a specific derivative thereof can make the pentacyclic triterpenes, which are mostly oil-soluble, enhance their water solubility. It is suitable for water and food applications. The water-based food prepared by blending physiologically acceptable salts or derivatives of oil-soluble maslinic acid can be exemplified, but is not limited to the scope of this exemplification. In addition, the present invention also contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof for anti-hypertrophy and / or excessive formation resistance Sexual obesity is related to coriander food. Bureau of Intellectual Property, Ministry of Economic Affairs, Industrial and Commercial Cooperative Cooperative Associations ^ • In addition, the present invention also contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. It may be related to preventing plumpness and / or treating plump foods. The present invention also relates to a diet food for weight loss which contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. In addition, the present invention also relates to a non-fatness-impairing coriander food product comprising one or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. This paper size applies Chinese National Standard (CNS) A4 specification (210X29 * 7 mm) -13- 200300069 A7 B7 V. Description of the invention (β The anti-fat food for use in the invention has a precursor fat cell proliferation inhibition function, Anti-fatty functions such as pro-lipid cell differentiation inhibition function, mature adipocyte fat accumulation inhibition function, etc., can be used to prevent obesity and / or therapeutic use, or to reduce weight and / or improve physical fitness. The purpose of the purpose is to provide the purpose of inhibiting the proliferation of precursor adipocytes or the differentiation or fat accumulation of mature adipocytes, so that the adipose tissue composed of new adipocytes is no longer produced and used. The purpose is to treat hypertrophy Use refers to inhibiting the proliferation of more precursor-type adipocytes, or inhibiting the differentiation of pre-adipocytes into mature adipocytes before excessive proliferation, and by inhibiting the differentiation of pre-adipocytes into mature adipocyte fat before receiving differentiation instructions, Used for reducing the number of hyperproliferative adipocytes or their precursor cells, and reducing the amount of adipose tissue As a result, it can inhibit and / or reduce the accumulation of subcutaneous fat or visceral fat, and prevent and / or treat fullness. Moreover, the purpose of weight loss refers to reducing the number of hyperproliferative fat cells or their precursor cells, and reducing The use of the amount of adipose tissue. In addition, the use for improving the body is not easy to use, refers to the use of inhibiting the formation of excessive hypertrophy in the growth period and use. The present invention relates to containing one or two or more pentacyclic triterpenes Pentenes and their physiologically acceptable salts, or anti-plump foods selected from the group of these derivatives, the pentacyclic triterpenes are usually a triterpene, consisting of 6 The pentacyclic compound formed by isoprene basically has 30 carbon numbers, but also includes those that are transferred, oxidized, detached, or alkylated during the biosynthesis step, and the carbon number will increase or decrease. The fertilizer of the present invention Pentacyclic triterpenes also include the pentacyclic triterpenes mentioned above in full-boiled foods. The physiologically acceptable salts of this paper are in accordance with China National Chestnut Standard (CNS) A4 (210X297 mm). ) (Please read the note on the back first Please fill in this page for more details)

, 1T Printed by the Co-op Workers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ^ -14- 200300069 A7 _ B7

V. Description of the invention (U (please read the notes on the back before filling this page) and / or these substituted derivatives of hydroxy or carboxyl groups, and there is no particular limitation on the source of these, which can be derived from nature Either artificially synthesized or commercially available products can be used, and in general, when it is considered to be used in glutinous food, it is advisable to use natural products in the present invention. Pentacyclic triterpenes are generally classified according to their architecture. The pentacyclic triterpenes in the present invention may be, for example, oleanol-type triterpenes, arbutin-type triterpenes, lupinane-type triterpenes, and heparane-type triterpenes , Ceracene triterpenes, corkane triterpenes, dandelion isane trisene, dandelion yellow courtyard three-way roasted, multifloran three te storage, Jarmanican three absolutely burned and so on. The “physiologically acceptable salt” of Yinzi, a cargo-worker consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, is a salt derived from the carboxyl group of pentacyclic triterpene acid (partial structure: -C00X; X series) Any cationic substance), the present invention may also include a single ion from a natural substance Originally included. The present invention is not particularly limited as long as it is a salt used in general food, for example, it may be an alkali metal salt such as sodium, potassium, lithium, or an alkaline earth metal salt such as calcium, magnesium, barium, or zinc, Alkylamine salts such as ammonia, methylamine, dimethylamine, trimethylamine, ethylamine, diethylamine, triethylamine, propylamine, butylamine, tetrabutylamine, pentylamine, hexylamine, ethanolamine, triethanolamine, propanol Amines, alkanolamine salts such as dipropanolamine, isopropanolamine, diisopropanolamine, hexahydropyridine, hexahydropyridine and other organic amine salts, lysine, arginine, histamine, Salts such as tryptophan and other basic amino acid salts. Among these, alkali metal salts, alkylamine salts, alkanolamine salts, and basic amino acid salts are preferred. These salts are usually more than the original five Cyclic triterpenes have better water solubility, so in the present invention, it is particularly suitable for water-based foods. This paper size is applicable to China National Standard (CNS) M pit (210X297 mm) " -15 -200300069 A7 B7 V. Description of the invention (j Also, as a derivative refers to a biochemical or artificially formed derivative and In the present invention, as long as it can be a derivative, there is no particular limitation. For example, it may be a derivative having an alcohol ester group, a derivative having a fatty ester group, a derivative having an alkoxy group, and a derivative having an alkoxymethyl group. Substances, or glycosides, etc. These particularly have alcohol ester groups, derivatives with fatty acid esters, alkoxy derivatives, and alkoxymethyl derivatives than their original pentacyclic tricyclic Terpenes have better fat solubility. The present invention is particularly suitable for use in oily foods. In addition, glycosides have better water solubility than the original pentacyclic triterpenes, which is especially suitable in the present invention. It is used in water-based foods. Some of these derivatives are naturally occurring and can be artificially formed. The derivatives of the present invention can be derivatized again using these salts. As mentioned above, pentacyclic triterpenes are made. It is in the form of a suitable salt or derivative that is physiologically acceptable, and can improve water solubility or oil solubility, so it can be a product that improves its operability, quality, and anti-fatty effect. Alcohol ester group refers to a functional group formed as a result of a dehydration reaction between a general carboxyl group and an alcohol (partial structure: a COOR; R represents an arbitrary hydrocarbon-based functional group). That is, the derivatives having an alcohol ester group of the pentacyclic triterpenes in the present invention are particularly derivatives which can be formed from a carboxyl group and an alcohol. The alcohols at this time are not particularly limited, but may be, for example, methanol, ethanol, n-propanol, isopropanol, allyl alcohol, n-butanol, second butanol, third butanol, ethylene glycol, and trimethylsilanol. , Triethylsilanol, phenol, benzyl alcohol, sugars, etc. Among them, derivatives derived from ethanol, triethylsilanol, methanol, n-propanol, isopropanol, and trimethylsilanol are suitable. This paper size applies to China National Standard (CNS) A4 (210X297 mm) Packing-(Please read the precautions on the back before filling out this page) Order P. Printed by the Intellectual Property Bureau of the Ministry of Economic Affairs, 8th Industrial Cooperatives-16 -200300069 A7 B7 V. Description of the invention (d (please read the precautions on the back before filling out this page) Fatty acid ester group refers to the functional group formed by the dehydration reaction of general hydroxyl and fatty acids (partial structure : -OCOR; R represents an arbitrary hydrocarbon-based functional group). That is, the derivative having a fatty acid ester group of the pentacyclic triterpenes in the present invention particularly means a derivative which can be formed from its hydroxyl group and fatty acid. In this case, fatty acids are not particularly limited, but may be, for example, acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, trimethylacetic acid, hexanoic acid, caprylic acid, capric acid, and undecanoic acid. , Lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, oleic acid, isoleic acid, oleic acid, linoleic acid, linoleic acid, linolenic acid, TV · linolenic acid, arachidic acid, Arachidonic acid, eicosapentaenoic acid, behenic acid, arsenic Hexene, carmitic acid, wax acid, montanic acid, melonic acid, etc. Among them are acetic acid, acetic anhydride, hexanoic acid, caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, palmitic acid, Stearic acid, oleic acid, oleic acid, linoleic acid, linoleic acid, linolenic acid, r-linolenic acid, peanut, arachidonic acid, eicosapentaenoic acid, behenic acid, arsenic acid Derivatives formed by enoic acid are suitable. The alkoxy group printed by the 5th Co., Ltd., 5th Co., Ltd. of the Ministry of Economic Affairs, Zhicicai Co., Ltd. shows functional groups formed by the dehydration reaction of general hydroxyl groups and alcohols (partial structure: -OR R represents an arbitrary hydrocarbon-based functional group). That is, the derivative having an alkoxy group of the pentacyclic triterpenes in the present invention particularly means a derivative which can be formed by its hydroxyl group and an alcohol. At this time, the alcohols are not It is not particularly limited, but may be, for example, methanol, ethanol, n-propanol, isopropanol, allyl alcohol, n-butanol, second butanol, third butanol, ethylene glycol, trimethylsilanol, and triethylsilanol. , Phenol, benzyl alcohol, sugars, etc. Among them are ethanol, triethylsilanol, methanol, n-propanol, isopropyl Derivatives formed by trimethylsilanol are suitable for this paper. Applicable to China National Standard (CNS) A4 (210X297 mm) -17 · 200300069 A7 B7 V. Description of the invention (14) (Please read the notes on the back before (Fill in this page) Alkoxymethyl is a functional group formed by the general dehydration reaction of methylol and alcohols (partial structure: -CH2OR; R is an arbitrary hydrocarbon functional group). Derivatives having cycloalkoxytriterpenes having alkoxymethyl groups are particularly derivatives which can be formed from their methylol groups and alcohols. At this time, the alcohols are not particularly limited but may be, for example, methanol, ethanol, or n-propanol. , Isopropanol, allyl alcohol, n-butanol, second butanol, third butanol, ethylene glycol, trimethylsilanol, triethylsilanol, phenol, benzyl alcohol, sugars, etc. Among them, derivatives derived from ethanol, triethylsilanol, methanol, n-propanol, isopropanol, and trimethylsilanol are suitable. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. In addition, in the present invention, the glycosides are derivatives of the alcohol ester group, derivatives of the alkoxy group, and derivatives of the alkoxymethyl group. Derivatives of triterpene carboxyl, hydroxy, methylol, and sugars (partial structure -COOR, -OR, -CH2OR; R shows any sugar). At this time, the sugar is not particularly limited, but may be, for example, glucose, mannose, galactose, fructose, xylose, arabinose, fucose, rhamnose, glucosamine, galactosamine, glucuronic acid, and may be an alpha , Any of the stones. In addition, these glycosides may be monosaccharides or oligosaccharides in combination of disaccharides or more. These are usually found in nature and known under the general name of saponin, and any of these can be used in the present invention. The pentacyclic triterpenes and the like in the present invention are as described above, and in particular, they are considered to have a high effect of inhibiting melanin production. The oleanolane tris®, ursane triterpenes, and lupinane are considered. These are triterpenes and their physiologically acceptable salts, or derivatives thereof. It has oleanolane triterpenes as shown in formula (1) and arbutane triterpenes as shown in formula (Π). The paper size is applicable to Chinese National Standard (CNS) A4 specification (210 × 297 mm). ) -18-200300069 A7 B7 V. Description of the invention (d (please read the notes on the back before filling this page), the pentacyclic triterpenes of the structure of lupinane triterpenes shown in formula (III) These physiologically acceptable salts, or derivatives thereof, and the functional groups in each formula are as described above.

(Wherein R ^ Ra; shows a hydrogen atom (-H), a hydroxyl group (-OH), an alkoxy group (· OR), an alcohol ester group (-OCor), R3 shows a methyl group (-CH3), a hydroxyl group Methyl (· CH2OH), alkoxymethyl (-CH2OR), carboxyl (-C00H), fatty acid ester (-COOR), carboxylate (-COOX))

Employees' Co-operative Co-operative Purple, Ministry of Economic Affairs, Ministry of Economic Affairs (where 1 shows hydrogen atom (-H), hydroxyl (-OH), alkoxy (-OR), alcohol ester group (-〇COR), R2 shows methyl (-CH3), hydroxymethyl (-CH2OH), alkoxymethyl (-CH2OR), carboxyl (-COOH), fatty acid ester (-COOR), carboxylate (-COOX) Sample standard (CNS) A4 specification (210X297 mm) — _ -19- 200300069 A7 B7 V. Description of the invention (4

(Please read the precautions on the back before filling out this page) (where 1 represents a hydrogen atom (-H), a hydroxyl group (-OH), an alkoxy group (-OR), an alcohol ester group (-OCOR), and R2 represents a form of (-CH3), hydroxymethyl (-CH2OH), alkoxymethyl (-CH2OR), carboxy (-COOH), fatty acid ester (-COOR), carboxylate (-COOX)). Wisdom blanket of the Ministry of Economic Affairs of the People's Republic of China, and the consumption cooperation of employees ^ Although the present invention is not particularly limited, for example, oleanolic triterpenes can be maslinic acid, oleyl alcohol, cocadiol, and melanoidin , Ivy glycoside configuration, glycyrrhizic acid, etc., as ursane triterpenes can be ursolic acid, ursitol, antlerin, isorhamic acid, tartaryl alcohol, hydroxyursolic acid, etc., lupin Alkane triterpenes can be betulinic acid, betulin, lupinol and the like. The physiologically acceptable salts and derivatives are as described above. When using these physiologically acceptable salts and derivatives, oleanol-type triterpenes, arbutin-type triterpenes, lupinane-type triterpenes, and these physiologically acceptable salts The source of these derivatives is not limited, and they can be used from natural sources, artificial synthesizers, and commercial products, and it is more appropriate to use natural products when considering the use of loquat food. As mentioned above, in the present invention, the oleanders of the pentacyclic triterpenes are the second-class suspects, (I) the bear fruit hospitals are the third-class suspects, (II) and the physiologically acceptable ones Salt, or a superior derivative, is suitable, but the Chinese National Standard (CNS) A4 specification (210X297 mm) applies to the paper size for anti-fertility effect. -20- 200300069 A7 B7 V. Description of the invention In other words, as the oleanolic triterpenes, maslinic acid and cocadiol are suitable, and as the ursane triterpenes, ursolic acid and ursyl alcohol are suitable. Terpenes are preferably betulinic acid and betulin, and of course these physiologically acceptable salts or derivatives thereof are also suitable. Cratalic acid and cocadiol are both oleanol triterpenes It is a kind of substance known to exist in various plants. In addition, these physiologically acceptable salts and derivatives are as described above. Hawthorn and cocadiol are used in the anti-plumid foods of the present invention, In the case of these physiologically acceptable salts or their derivatives, the source of these substances is not limited and may be derived from nature Either artificially synthesized or commercially available products can be used, but it is advisable to use natural products when the present invention is to eat or eat. In the present invention, regarding the level of the anti-fatness effect, it is stable to supply it with maslinic acid. And / or its physiologically acceptable salt is the best. Maslinic acid is one of the three IS burners of the Oden Fruit Academy. It has no chemical formula (IV) structure and has an anti-inflammatory effect or The anti-histamine effect is known. Natural people have known that it exists in olives, hubu, mint, pomegranate, clove, sage, jujube, etc. In the anti-plump foods of the present invention, maslinic acid, The source of the physiologically acceptable salts and derivatives is not limited, and may be any one obtained from natural sources, artificial synthesizers, and commercial products, but considering that the present invention is in the form of glutinous food, For example, natural sources such as olive oil, hubu, mint, pomegranate, clove, sage, jujube and the like are suitable. In particular, maslinic acid and / or physiologically acceptable salts thereof obtained from olive olive are extremely important in terms of raw material supply or content. Ideal. Maslinic acid and / or its physiology The permissible salt is from these raw materials, especially from the olive plant. The paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm 1 ~ -21- (Please read the precautions on the back before (Fill in this page) Order the Consumers ’Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs to print 200300069 A7 B7 V. Description of the invention (4 Water and / or organic solvents can be obtained through extraction treatment, and can be concentrated, refined and can be simply and in large quantities Obtaining a high concentration of naturally-derived maslinic acid and / or physiologically acceptable salts thereof. In the present specification, "foreign olive" means the olive plant and / or the olive oil and / or the olive oil obtained during the manufacturing process. Product.

The physiologically acceptable salts and derivatives of maslinic acid in the present invention are as described above. That is, the physiologically acceptable salt is derived from -COOH in Chemical Formula (IV), and the type of the salt is usually not particularly limited as long as it is used in food or pharmaceutical composition. Specifically, for example, the salt of maslinic acid may be sodium maslinate, potassium maslinate, ammonium maslinate, dimethylammonium maslinate, calcium maslinate, magnesium maslinate, and the like. Among them, sodium hawate and potassium hawate are suitable. In addition, the derivatives of maslinic acid are, for example, those derived from any part thereof, and may be methyl maslinate, ethyl maslinate, n-propyl maslinate, isopropyl maslinate, n-butyl maslinate, and maslinic acid. Trimethylsilyl ester, triethyl maslinate, maslinic acid-yS-D-glucopyranyl ester, maslinic acid-Ling-D-galactopyranoate, 3-0-acetamyl maslinic acid, 3 -0-Propanyl-maslinic acid, 3-0- This paper size applies to China National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before filling out this page). Hour / 1 笱 ® Industrial Consumption and ITFI Printing ¾ -22- 200300069 A7 B7 V. Description of the Invention (1¾ (Please read the precautions on the back before filling out this page) Butyl-cratalic acid, 3- 0-pentyl-hawthorn Acid, 3- 0-decanoyl-maslinic acid, 3- 0-lauryl-maslinic acid, 3- 0-myristyl-maslinic acid, 3-0-palmityl-maslinic acid, 3-0-palmitine Base-maslinic acid, 3-0-stearyl-maslinic acid, 3-0-oleyl-maslinic acid, 3-0-isooleyl-maslinic acid, 3.0-linolenic-maslinic acid, 3-〇 -Linoleyl-maslinic acid, 3-〇-arachidyl maslinic acid, 3- 0-flower Alkenyl · maslinic acid, 3- 0-massyl · maslinic acid, 2-〇-ethylamyl-maslinic acid, 2-〇-propanyl-maslinic acid, 2-〇-butanyl-maslinic acid, 2-〇 · pentanoyl-maslinic acid, 2- 0-decanoyl-maslinic acid, 2- 0 · lauryl-maslinic acid, 2- 0-myristyl-maslinic acid, 2- 0-palmityl- Cratalic acid, 2- 0-palmitinyl · cratalic acid, 2- 0-stearyl-cratalic acid, 2- 0-oleyl-cratalic acid, 2- 0-isooleyl-cratalic acid, 2- 0 · Linolenic-maslinic acid, 2- 0-linoleyl-maslinic acid, 2- 0-arachidyl-maslinic acid, 2- 0 · arachidene-maslinic acid, 2-0-massyl-maslinic acid, 3.0-methyl-maslinic acid, 3- 0-ethyl-maslinic acid, 3- 0-tertiary butyl-maslinic acid, 3- 0-triethylsilyl maslinic acid, 3-〇- / 9 -D-glucopyranyl-maslinic acid, 3- 0- / 3-D-galactopyranosyl · maslinic acid, 3-0-glucuronylpyranyl · maslinic acid, employee of the Ministry of Economic Affairs Printed by consumer cooperatives, especially ethyl maslinate, triethylsilyl maslinate, 3- 0-ethylenyl maslinic acid, 2-0-ethylenyl-maslinic acid, 2-0-triethylsilyl -Cratalic acid, 3-stearyl-hawthorn And 2- 0-stearyl-maslinic acid is suitable. The above list refers to those in which only one group is derivatized as a derivative, but even if the derivatizable position and type in these are two or more groups, it is derivatized. Of course, it is also possible. For example, maslinic acid or the above-mentioned preferred maslinate, 3,3- 0-diethylfluorenyl, 2,3 · 0.0 · triethylsilane, 2,3-distearyl carbohydrate, specifically The better paper size is applicable to Chinese National Standard (CNS) A4 specification (210X29 * 7mm) -23-200300069 A7 _B7_ V. Description of the invention (2¾ (Please read the precautions on the back before filling this page). 2,3- 0-diethylfluorenyl, maslinic acid, 2,3- 0-triethylsilyl, triethylsilyl maslinate, and 2,3- 0-distearylyl-maslinic acid. In addition, although glycosides are only monosaccharides, oligosaccharides grouped by two or more kinds of saccharides can be selected. Cocadiol (erythrodiol) is one of the triterpenoids of the oleanolic system, such as the structure of formula (V), and its effect has hitherto been known to have an anti-inflammatory effect (Planta.Med.V0L.61, No. 2, 1 82- 1 8 5, 1 995) and so on. Natural beings are known in the lines of olives, sunflowers, calendula, acacia, red sandalwood, and large-leaf stolons. The origin of cocadiol or these derivatives in the anti-fattiness foods of the present invention is not limited, and may be naturally derived, artificially synthesized, or any of the commercially available products, but considering food consumption It is suitable to use natural income such as olive, sunflower, calendula, acacia, red sandalwood, big leaf bun, etc. In particular, olives are preferred, and in particular, those derived from by-products obtained from olive olive plants and / or olive oil manufacturing processes are preferred.

Regarding cocadiol, physiologically acceptable salts or derivatives thereof are as described above. Here, the related derivatives are not limited by the following, but for example, as a paper standard, the Chinese National Standard (CNS) A4 specification (210X297 public 41 ----- -24-200300069 A7 _B7___ V. Description of the invention ( 21) (Please read the notes on the back before filling out this page) The Ministry of Economic Affairs, the Intellectual Property and Welfare Bureau of the 4th Bureau of the Consumer Consumption Coordinator printed a derivatized part of the site, which can be 3- 0-acetyl-cocadiol, 3- 0-propanyl-cocadiol, 3-0-butanyl-cocadiol, 3-0-pentanyl-cocadiol, 3-0-decyl-cocadiol, 3- 0 · lauryl-cocadiol, 3- 0-myristoyl-cocadiol, 3- 0 · palmityl-cocadiol, 3-0-palmitinyl-cocadiol, 3- 0-stearyl-cocadiol, 3-0-stearyl-cocadiol, 3-0-oleyl-cocadiol, 3-0-isooleyl-cocadiol, 3- 0-linoleyl-cocadiol, 3-0-linoleyl-cocadiol, 3-0-arachidyl-cocadiol, 3-0-arachidene-cocadiol , 3-0-behenyl-cocadiol, 28-0-〇-ethyl-cocadiol, 28-0-propanyl-cocadiol, 28-0-butanyl-coca Diol, 28-0-pentamyl- Cocodiol, 28-0-decylenyl cocadiol, 28-0 Lauryl-cocadiol, 28-0 myristyl-cocadiol, 28-0-palmityl-gu Cocodiol, 28-0-palmitenyl cocadiol, 28-0-stearyl-cocadiol, 28-0 oil-cocadiol, 28-0-isooleyl- Cocadiol, 28-0-linoleyl-cocadiol, 28-0-linoleyl-cocadiol, 28.0-arachidyl-cocadiol, 28-0-arachidene -Cocadiol, 28-O. Behenyl-cocadiol, 3-0-methyl · cocadiol, 3-0-ethyl-cocadiol, 3-0-tertiary butane Cocadiol, 3.0-triethylsilyl-cocadiol, 28.0-methyl-cocadiol, 28-0-ethyl-cocadiol, 28-0- Tributyl-cocadiol, 28.0-triethylsilyl-cocadiol, 3-0- / 3-D-glucopyranyl-cocadiol, 3-0 · galactopyranoate Uranyl_cocadiol, 3- 0-stone · D-glucuronylpyranyl-cocadiol, 28 · 〇- / 3-D · glucopyranyl-cocadiol, 28- 0-Lu-D-galactopyrano This paper is sized for China National Standard (CNS) A4 (210X297 mm) 200300069 A 7 ____B7 V. Description of the invention (d-cocadiol, 28-0-y3-D-glucuronopyranyl coca di (Please read the notes on the back before filling this page) alcohol, etc. Among them, 3-0 · ethylfluorenyl-cocadiol and 28-0-ethylfluorenyl-cocadiol are preferable. The above list only refers to those who have only one base being derivatized as a derivative, but the position and type of derivatization in these may also be those derivatizing more than two bases. For example, it may be 3,28-0-diethylfluorenyl-cocadiol. The glycosides are only monosaccharides, but they may be oligosaccharides selected from the group consisting of disaccharides of various sugars. Ursolic acid and ursitol are both types of ursane triterpenes, and they are known to exist in various plants. The physiologically tolerable salts and derivatives are as described above. When ursolic acid, ursitol, these physiologically tolerable salts, or these derivatives are used in the food for preventing obesity in the present invention, the source of these substances is not particularly limited. Naturally derived, artificially synthesized, and commercially available products can be used, but when considering the application to food, etc., it is advisable to use natural products. Ursolic acid is one of the ursane triterpenes. The compound of formula (VI) is known to have anti-inflammatory, anti-obesity, anti-diabetic and anti-high Lipemia (Jie Liu, Journal of Ethnopharmacology, 49, 5 7-68, 1 995) and so on. Natural ones are widely known in apples, cherries, bear berries and other fruits or leaves. The fat-reducing foods of the present invention are ursolic acid, physiologically acceptable salts, or the like. The source of the derivative is not particularly limited, and it can be used naturally, artificially synthesized, or any of the commercially available products. However, when it is considered to be used for food, etc., it can be derived from natural products such as apple, cherry, and bearberry The winner is better. This paper scale is applicable to China National Standard (CNS) A4 (21GX297 mm) surface -26- 200300069 A7 B7 V. Description of the invention (2¾ CH,

For ursolic acid, these physiologically acceptable salts or derivatives are the same as above. Although the physiologically acceptable salt is not limited here, for example, the salt of ursolic acid may be sodium ursolic acid, potassium ursolic acid, ammonium ursolic acid, ursyl @ dimethyl ammonium, ursolic acid. Calcium, magnesium ursate, etc. In addition, the derivatives of ursolic acid are, for example, those derivatized at any part thereof, and may be methyl ursolic acid, ethyl ursolic acid, n-propyl ursolic acid, isopropyl ursolic acid, and ursolic acid. N-butyl ester, trimethylsilyl ursolic acid, triethylsilyl ursolic acid, ursolic acid-/ 5-D-glucopyranyl ester, ursolic acid / 3-D-galactopyranoate, 3 -0 · Acetyl-ursolic acid, 3- 0-propanyl-ursolic acid, 3- 0 · butanyl · ursolic acid, 3.0 · pentamyl-ursolic acid, 3- 0-decyl Fluorenyl-ursolic acid, 3- 0-lauryl-ursolic acid, 3- 0-myristyl-ursolic acid, 3-0 · palmityl-ursolic acid, 3-0-palmitinyl · bear Fruit acid-3, -0-stearyl-ursolic acid, 3.0-oleyl-ursolic acid, 3-0-isooleyl, ursolic acid, 3-0-linoleyl · ursolic acid, 3- 0-linoleyl-ursolic acid, 3-0-arachisyl · ursolic acid-3-0-arachisin-alkenyl-ursolic acid, 3.0- behenyl-ursolic acid, 3- 0-methyl · ursolic acid, 3- 0 · ethyl-ursolic acid, 3- 0 · tertiary butyl-ursolic acid, 3- 0-triethylsilyl-ursin paper standards applicable to Chinese national standards (CNS) A4 size (210X297mm) (Please read the notes on the back first Then fill the page). Installed.

, 1T Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ^ -27- 200300069 A7 B7 V. Description of the invention (2i fruit acid, 3-0- yS-D-glucopyranyl · ursolic acid, 3-0- Galactopyranos-ursolic acid, 3- 0-D-glucuronyl-pyranyl-ursine (please read the precautions on the back before filling this page) fruit acids, etc., especially ethyl ursolic acid is It is only mentioned above that only one base is derivatized as a derivative, but the position and type of derivatization in these may also be derivatized with more than two bases. Moreover, glycosides are only monosaccharides, However, it can also be selected from oligosaccharides of disaccharides or more grouped by various sugars. Ursolic acid (urol) is one of the ursane triterpenes, which has a structural formula such as formula (VII), and its function has been The reader has anti-inflammatory effects (Planta.med.V0L.61, No.2, 1 82- 1 85, 1995), glycerol phosphate dehydrogenase blocking effect (Japanese Patent Application Laid-Open No. 9-67249), etc. It is known to exist in nature In olive oil, bear berry, sage, acacia tree, white Melaleuca, etc. In the anti-fertilization food of the present invention, the source of arsitol or these derivatives is not limited and can be used from Of course, any one of the obtained, artificially synthesized, marketed goods, etc., but when the present invention is considered to be in the form of tadpole food, it is obtained from natural objects such as olives, bear berries, sage, acacia, and melaleuca. It ’s better. Especially the olives are suitable, specifically the ones obtained from the by-products of olive olive plants and / or olive oil manufacturing process. CH3 printed by the Ministry of Economic Affairs / i Bureau 8 工 消 Φ Cooperative print CH3

The physiologically tolerable salt or derivative of arsitol is the same as the above paper size applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) -28- 200300069 A7 B7 _ V. Description of the invention (2 (Please read the precautions on the back before filling out this page) Printed by the 8th Industrial Cooperative Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ¾ Here, the related derivatives are not restricted as follows, but for example, they are derived from a part Then it can be 3.0-ethenyl-arsitol, 3-0-propanyl-arsitol, 3-0-butanyl-arsitol, 3-0-pentyl-arsanol, 3 -0-decylmethyl-arsanol, 3-0-lauryl-arsitol, 3-0-myristyl-arsitol, 3-0-palmityl-arsitol, 3-0-palm Fluorenyl-arsanol, 3-0-stearyl-arsanol, 3-0-oleyl-arsitol, 3-0-isooleyl-arsitol, 3-〇 · linoleyl-bear Alcohol, 3-0-linoleyl-arsanol, 3_0-arachisyl-arsanol, 3-0-arachisyl arbutin, 3-0-behenyl-arsanol, 28 -0-Ethyl-arsanol, 28-0-propanyl-arsanol, 28-0-butanyl-arsanol, 28-0-pentyl-arsanol, 28-0-decyl Yen Kei- 28-0-Lauryl-Arsanol, 28-0-Myristylarsanol, 28-0-Palmyl-Arsanol, 28-0-Palmyl-Arsanol, 28 -0-stearyl-arsanol, 28-0-oleyl-arsitol, 28-0-isooleyl-arsitol, 28-0-linoleyl-arsanol, 28-0-sub Oleyl-arsanol, 28-0-arachisyl-arbutin, 28-0-arachisyl-arbutin, 28-0-behenyl-arsanol, 3-0-methyl- Arbutol, 3-0-ethyl-arsitol, 3-0-third butyl-arsitol, 3-0 · triethylsilyl-arsitol, 28-0-methyl-arsanol Alcohol, 28-0-ethyl · arsitol, 28-0-third butyl-arsanol, 28-0-triethylsilyl-arsanol, 3-0-; SD-glucopyridine Uranyl-arsanol, 3-0-cold-D-galactopyranosyl-arsanol, 3-0-stone-D-glucuronopyranyl-arsanol, 28-0-Ling- D-glucopyranyl-arsanol, 28-〇 · -D-galactopyranosyl-arsanol, 28-0-cold-D-glucuronyl-pyranyl-arsanol, etc., among which 3-0-Ethyl-arsanol, 28-0-Ethyl-arsanol are suitable. The above are just listed as derivatives, and only one base is derived. This paper applies the Chinese National Standard (CNS) ) A4 specifications (210X297 mm) -29 · 200300069 A7 _____B7_ V. Description of the invention (2 & (Please read the precautions on the back before filling this page), but the position and type derived from these can also be two Bases are derivatized. For example, it may be 3,28-diethylfluorenyl-arsanol. The glycosides are only monosaccharides, but they may be oligosaccharides selected from the group consisting of disaccharides of various sugars. Betulinic acid and betulin are both types of lupinane triterpenes, and they are known to exist in various plants. The physiologically tolerable salts and derivatives are as described above. When betulinic acid and betulin are used in the anti-fattiness foods of the present invention, the physiologically acceptable salts, or derivatives thereof, the source of these substances is not particularly limited and can be used Either from a natural source, an artificially synthesized product, or a commercial product, but when considering the use of food, etc., it is advisable to use a natural product. Printed by the Consumers ’Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ^ One of the betulinic acid-based lupinane triterpenes, such as the structure of formula (VIII), is known to have carcinogenesis, anti-inflammatory effects, and promote wound Healing effect (JP 4-26623), inhibition of alcohol absorption (JP-A 7-53385), promotion of hair growth (JP-A 9- 1 57 1 39), etc. Natural system is in free state in medicine, clove, grape peel, olive, etc., and saponin exists in bamboo ginseng, ginseng, beet and so on. The origin of betulinic acid, these physiologically acceptable salts, or these derivatives in the food for preventing obesity in the present invention is not limited, and may be naturally derived, artificially synthesized, or marketed. Any one of the products can be used, but it is considered that the present invention is in the form of coriander food, and it is preferably obtained from natural products such as medicine, cloves, grapes, olives, bamboo ginseng, ginseng, beet and the like. In particular, those obtained from olive oil are suitable, and specifically those obtained from olive oil plants and / or by-products obtained in the step of producing olive oil are suitable. This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) " • 30-200300069 A7 B7 V. Description of the invention (2)

The physiologically acceptable salts or derivatives of betulinic acid are as described above. Although the physiologically acceptable salts are not necessarily limited to the following, for example, betulinic acid may be sodium betulinate, potassium betulinate, ammonium betulinate, dimethylammonium betulinate, calcium betulinate, and magnesium betulinate. Wait. Among them, sodium betulin and potassium betulinate are suitable. In addition, if any of the derivatives of betulinic acid is derivatized, it may be methyl betulinate, ethyl betulinate, n-propyl betulinate, isopropyl betulinate, n-butyl betulinate, or trimethyl betulinate. Silyl ester, triethylsilyl betulinate, betulinic acid- / 3-D-glucopyranyl ester, betulinic acid cold-D-galactopyranoate, 3-0-acetamido-birulinic acid, 3-0 -Propanyl-Betulinic acid, 3-0-Butyl-Betulinic acid, 3-0 · Pentyl-Betulinic acid, 3-0 · Decyl-Betulinic acid, 3-0-Lauryl-Betulinic acid, 3 -0-Myristyl-Betulinic acid, 3-0-Palmyl-Betulinic acid, 3-0-Palmitinyl-Betulinic acid, 3-0-Stearyl-Betulinic acid, 3-0-Oleyl-Birch Acid, 3-0-iso-oleyl-betulinic acid, 3_0-linoleyl-betulinic acid, 3_0 · linoleyl-betulinic acid, 3-0-arachidyl-betulinic acid, 3-0-arachidene-bienyl-birch Acid, 3-0-Behenyl-Betulinic Acid, 3-0-Methyl-Betulinic Acid, 3-0-Ethyl-Betulinic Acid, 3-0-Tertiary Butyl-Betulinic Acid, 3-0-Tri Ethylsilyl-betulinic acid, 3-0- / 3-D-glucopyranine This paper is sized for China National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back first (Write this page). Order. Printed by the Consumer Cooperatives of the 4th Bureau of Wisdom and Finance of the Ministry of Economy -31-200300069 A7 _B7_ V. Description of the invention Betulinic acid, 3-0- / 3-D-glucose (please read the precautions on the back before filling out this page) sugar pyranyl betulinic acid, etc. Among them, ethyl betulinate is preferred. The above are just examples Derivatives have only one base being derivatized, but the position and type of these derivatives can also be derivatized with more than two bases. In addition, glycosides are only monosaccharides, but they can also be selected from various Oligosaccharides with more than disaccharides grouped by carbohydrates. Butulin is one of the lupinane triterpenes and has a structure like formula (IX). It is known to have the effect of inhibiting the denaturation of living proteins ( Kaiping 9-6725 3), blocking the action of glycerol phosphate dehydrogenase, blocking lipase (Japanese Patent Application No. 10-265328), preventing liver diseases (Japanese Patent Application No. 1 1-209275), etc. It is known to exist in white birch in nature The bark, etc. The origin of betulin or these derivatives in the anti-plump foods of the present invention is not limited, but Those obtained from any of a synthetic natural persons, and the like can be used commercially available products, but the present invention is considered Yin food form, for example, from the birch bark obtained by appropriate natural.

Printed by the Employees' Cooperative of the 1st Bureau of the Ministry of Economic Affairs, Consumer Cooperatives. The physiologically acceptable salts of betulin are as described above. Here, the related derivatives are not limited as follows, but for example, as a fiL derivatized person, it can be 3-0-ethyl-betulin, 3-0 · propanol-based. This paper standard applies China National Standard (CNS) A4 Specification (210X297mm) " I '--32-200300069 A7 B7_____ V. Description of Invention (d (Please read the notes on the back before filling this page) Bureau 8 Industry Consumer Cooperative Co., Ltd. ¾ Betulin, 3-0-Butyl-Betulin, 3-0-Pentyl-Betulin, 3-0-Decyl-Betulin, 3-0-Lauryl-Betulin , 3-0-Myristyl-Betulin, 3-0-Palmityl-Betulin, 3-0-Palmityl-Betulin, 3-0-Stearyl-Betulin, 3-0-Oleol -Betulin, 3-0-Isoyl-Betulin, 3-0-Linolenyl-Betulin, 3-0-Linyl-Betulin, 3-0-Arachidyl-Betulin, 3-0- Peanut AldenylBetulin, 3-0-Behenyl-Betulin, 28-0-Ethyl-Betulin, 28-0-Propanyl-Betulin, 28-0-Butyl-Betulin, 28-0-pentamyl-betulin, 28-0-decyl-betulin, 28-0-lauryl-betulin, 28-0-myristyl-betulin, 28-0- Palmityl-bentyl alcohol, 28-0-palmitinyl-betulin, 28-0-stearyl-betulin, 28-0-oleyl-betulin, 28-0-iso-oleyl-litolol, 28-0 -Linolenyl-linol, 28-0 -linoleyl-birulin, 28-0-arachidyl-bulinol, 28-0-arachidene-benzyl alcohol, 28-0-behenlin -Betulin, 3-0 · Methyl-Betulin, 3-0-Ethyl Betulin, 3-0-Third-butyl-Betulin, 3-0-Triethylsilyl · Betulin, 28 -0-Methyl-Betulin, 28-0-Ethyl-Betulin, 28-0-Third-butyl-Betulin, 28-0-Triethylsilyl-Betulin, 3-0- / 5- D-Glucosylpyranyl-Betulin, 3-0- ^ SD-galactopyrano-Betulin, 3-0- ^ SD-glucuronyl Pyranyl-Betulin, 28-0- / 3 -D-glucopyranyl-birulinol, 28-0.0 million-D-galactopyranosyl-birulinol, 28-0-; SD-glucuronopyranyl-birulinol, etc., among which 3 -0-ethenyl-betulin and 28-0-ethenyl-betulin are suitable. The above are just examples of derivatives that have only one base being derivatized, but the positions and types of derivatization in these are also It may be derivatized with two or more radicals. For example, it may be 3,28 · diethylfluorenyl- Xylitol. In addition, the glycosides are only monosaccharides, but they can also be oligosaccharides selected from the disaccharides grouped by various sugars. This paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) ） ~ &Quot; " -33-200300069 A7 B7 V. Description of the invention (3J) (Please read the notes on the back before filling out this page) The Intellectual Property Bureau of the Ministry of Economic Affairs, Zhengong Consumer Cooperative, printed this invention for anti-fullness The food and drink exhibit its anti-puffiness function when taken orally. In the present invention, the function of anti-puffiness refers to directly inhibiting the proliferation of precursor adipocytes, inhibiting the differentiation of precursor adipocytes into mature adipocytes, and inhibiting precursor adipocytes to become mature adipocytes. In the end, it can prevent and improve pathological plumpness, and if necessary, can lose weight or create a body that is not easy to plump, so that it can give the desired function whether it is cosmetic or psychological. The aforementioned prodromal adipocytes refer to the prodromal cells that are present in adipose tissue and can be increased in number by proliferation factors, and become mature adipocytes that can accumulate fats ingested by the composition factor. Generally speaking, the so-called fullness refers to the state in which excess fat is accumulated in the body, which is caused by excessive proliferation of adipose tissue composed of fat cells that can store fat. Therefore, it can inhibit the formation of adipose tissue and the proliferation of precursor-type adipocytes. Naturally, it can prevent, improve obesity, lose weight or become less obese. In this regard, the food for preventing fullness of the present invention contains a pentacyclic tri-functional anti-fullness function having a function of inhibiting the proliferation of precursor adipocytes, inhibiting the differentiation of precursor adipocytes, and inhibiting the accumulation of fat from mature adipocytes. Terpenes and their physiologically acceptable salts or derivatives thereof. Therefore, it is very useful to be able to prevent, improve plumpness, lose weight or become less fit. In other words, the anti-fatty foods of the present invention can exhibit their anti-fullness function by ingestion, specifically, by inhibiting the accumulation of subcutaneous fat or visceral fat or reducing the accumulated fat, etc., for preventing and improving the fullness , Or contribute to weight loss or make it difficult to plump body. As mentioned above, plumpness refers to the state of excessive accumulation of fat in the body. It is considered that the adipose tissue hyperplasia is composed of fat cells that can accumulate fat. The paper & standard is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm). 1 -34-200300069 A7 _B7_ V. Description of the invention (3ί (please read the precautions on the back before filling this page), however, it is known that this type of hypertrophy and hyperlipidemia, diabetes, arteriosclerosis, coronary artery disease Diseases or cerebrovascular diseases are closely related (Reference, Itakura ed .: The Science of Lipids, pp. 135 ~ 153, 1999). Therefore, it is possible to prevent the number of fat cells or the accumulation of fat in fat cells. Or improve vascular disease such as hyperlipidemia, its associated hyperlipidemia, diabetes, arteriosclerosis, coronary artery disease, or cerebrovascular disease. In this regard, the anti-fatty food product of the present invention contains a precursor-type fat cell inhibitor Gongcang g, pentacyclic triterpenes with anti-fullness function, such as precursor type adipocyte differentiation inhibition function, mature adipocyte fat accumulation inhibition function, etc. Physiologically acceptable salts or derivatives thereof, it can be expected that it will minimize the occurrence of obesity or subsequent vascular diseases such as coronary artery disease or cerebrovascular disease. In other words, the anti-fertility of the present invention Manchurian food exhibits its anti-puffiness function by ingestion, and can further improve or prevent coronary artery disease or cerebrovascular disease, etc., and also contributes significantly to longevity and longevity. The pentacyclic triterpenes mentioned above and their physiological tolerance The salts or derivatives thereof have the function of inhibiting proliferative adipocyte proliferation. Printed by the Consumer Cooperative of the Intellectual Property Office of the Ministry of Economic Affairs ¾ In the present invention, the function of inhibiting proliferative adipocyte proliferation refers to inhibiting the precursor adipocytes in adipose tissue The function of proliferation in adipose tissue, as a result, it can be expected that it can prevent the proliferation of adipose tissue, or the existing adipose tissue is no longer hypertrophic, and even the effect of shrinking. It is used in the present invention to evaluate the proliferation of precursor adipocytes The method of inhibiting function is to use known methods for screening substances with anti-hypertrophy function in test tube test (refer to Satory People, J. Nntr. 1 29: 92-97, 1999), which is characterized by easy screening, fast, and avoidance of many experimental animals. In the present invention, the paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) before use. The " -35- 200300069 A7 B7 V. Description of the invention (3 full (please read the precautions on the back before filling out) (This page) A test drug that can produce fluorescent substances by the redox ability of the drive-type adipocytes. The amount of fluorescent substances produced is measured by the intensity of the fluorescent intensity, and the presence or absence of a proliferation inhibitory function is examined. The pentacyclic triterpenes and their physiologically acceptable salts or derivatives thereof have a precursor-type adipocyte proliferation inhibition function, which can be shown by a test method using a precursor-type adipocyte. The precursor-type fat used in the present invention Cells are derived from mouse-derived precursor-type adipocytes. The cells are cultured in the usual way and have a multiplier capacity of 18 hours. Double cells are formed on the culture medium. In contrast, these cells exist in this culture line. When there is a substance capable of inhibiting the proliferation of precursor adipocytes, the proliferation of precursor adipocytes is suppressed, and the cell's redox capacity is relatively Inhibited, the amount of fluorescent substance produced is also reduced and the fluorescence intensity is also weakened. From this relative situation of fluorescence intensity, the proliferative fat cell proliferation inhibition function can be evaluated. Printed by the Consumers ’Cooperative of Intellectual Property Bureau of the Ministry of Economics The above test method evaluates and compares the pentacyclic triterpenes in the present invention and their physiologically acceptable salts or their derivatives with precursor-type adipocyte proliferation inhibition function and CL A, which is a well-known substance with anti-hypertrophic function For example, maslinic acid has about 2 to 30 times, maslinate is about 2 to 28 times, cocadiol is about 2 to 25 times, ursolic acid is about 2 to 60 times, and ursolic acid is about 2 ~ 8 times, betulinic acid is about 2 ~ 10 times, betulin is about 2 ~ 12 times, ethyl maslinate is about 2 ~ 30 times, acetic acid is about 2 ~ 28 times, triethylsilylation The amount of maslinic acid is about 2 to 2 8 times, the amount of stearic ethyl maslinate is about 2 to 3 2 times, the amount of acetic cocadiol is about 2 to 4 4 times, and the amount of ethyl ursolic acid is about 2 to 4 8 times, acetic acid arbutol is about 2 to 12 times, ethyl betulinate is about 2 to 12 times, ethylated betulin paper > ^ 1 (CNS) (published by 21GX297)--36-200300069 A7 B7_ V. Description of the invention (d (Please read the precautions on the back before filling out this page) The inhibition of high precursor-type adipocyte proliferation is about 2 to 12 times In other words, since the gluten-resistant food for anti-plumbing of the present invention contains pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof, it can be stronger than CLA with a high anti-plumping function. Proliferative adipocyte proliferation inhibition function. The pentacyclic triterpenes and their physiologically acceptable salts or derivatives thereof have a precursor adipocyte differentiation inhibition function. The precursor adipocyte differentiation inhibition function refers to inhibition Differentiation factors act on precursor adipocytes, and inhibit the differentiation of precursor adipocytes into mature adipocytes. As a result, inhibiting the production of mature adipocytes can prevent the formation of new adipose tissue or make existing adipose tissue Do not become premature adipocytes. In the present invention, during the differentiation, the effect of the aforementioned substances and the like is used to compare the differentiation with the control group and determine the presence or absence of a differentiation-inhibiting function by the amount of neutral fat (triglyceride) taken up by mature adipocytes after maturation. The Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed the pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof of the present invention in a precursor-type adipocyte differentiation inhibiting function. The precursor-type adipocytes can be used by The test method is shown. The precursor-type adipocytes used in the present invention are derived from mouse-cultured precursor-type adipocytes. In order to differentiate the cells into adipocytes, bovine fetal blood corpuscle, dexamethasone (fluxamone), and 3 · iso Butyl-1 · methylxanthine and insulin, and other differentiation factors act, and by this effect, precursor adipocytes differentiate into adipocytes. In contrast, if there is a substance with a function of inhibiting differentiation in the differentiation stage, the number of mature adipocytes will decrease, or the amount of triglyceride in the cells will decrease. Comparing the reduction of the above triglyceride with the control group, it can be evaluated that the previous paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -37-200300069 A7 ____ B7 V. Description of the invention (3) Type adipocyte differentiation inhibition function. (Please read the notes on the back before filling this page.) Assess the pentacyclic triterpenes of the present invention and their physiologically tolerable salts or their derivatives as precursor-type adipocyte differentiation inhibitory functions according to the above test method, and When comparing CL A, which is a well-known substance with anti-pigmentation function, for example, maslinic acid has about 2 to 22 times, maslinate is about 2 to 20 times, cocadiol is about 2 to 20 times, and ursolic acid is About 2 to 18 times, arbutol is about 2 to 16 times, betulinic acid is about 2 to 18 times, betulin is about 2 to 20 times, ethyl hawate is about 2 to 2 2 times, and acetylated hawthorn The acid is about 2 to 22 times, the triethylsilylated maslinic acid is about 2 to 20 times, the hard esterified maslinic acid ethyl ester is about 2 to 22 times, and the ethyl acetate cocadiol is about 2 to 20 times. Ethyl ursolic acid is about 2 to 18 times, acetylated arsitol is about 2 to 18 times, ethyl betulinate is about 2 to 18 times, and acetated betulin is about 2 to 20 times as high. Precursor fat breakdown function. In other words, the fermented food for preventing fullness of the present invention contains a pentacyclic triterpene and a physiologically acceptable salt or a derivative thereof, and has a stronger precursor-type adipocyte differentiation inhibiting function than CLA. The pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof have the function of inhibiting fat accumulation in mature adipocytes. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, this mature fat cell fat accumulation inhibition function refers to the current type of fat cells that are stimulated by differentiation factors to inhibit them from becoming so-called mature adipocytes that can accumulate fat in the cell. In this case, as a result, it is possible to suppress the production of newly mature adipocytes and prevent the further formation of adipose tissue, or to expect that the preexisting adipocytes in the existing adipose tissue will not become mature adipocytes after being stimulated by differentiation factors. In the present invention, the above-mentioned substances are used to drive the fat before being stimulated by differentiation factors. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) -38- 200300069 A7 ___B7___ V. Description of the invention (3¾ (please first Read the notes on the back and fill in this page again) Cells will differentiate into shaped adipocytes, and the amount of neutral fat (ie, triglyceride) taken up by the cells after accumulating fat is compared with the control group to evaluate whether there is mature adipocyte fat Accumulation inhibition function. The fat accumulation inhibition function of mature adipocytes of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof in the present invention can be shown by a test method using precursor adipocytes. The precursor-type adipocytes used in the invention are derived from mouse-cultured precursor-type adipocytes. To differentiate the cells into adipocytes, bovine fetal blood corpuscle, dexamethasone, and 3-isobutyl-1-methyl must be used. The role of differentiation factors such as xanthine and insulin. From this role, precursor fat cells begin to differentiate into adipocytes, and then mature into mature fat cells. On the other hand, when matured adipocytes are differentiated, if there is co-existence of substances with the function of inhibiting fat accumulation in mature adipocytes, the number of mature adipocytes will decrease, or the amount of triglyceride taken up inside the cell will decrease. Comparing the reduction of the amount of triglyceride mentioned above, the function of inhibiting fat accumulation in mature adipocytes can be evaluated. Printed by the Employees' Cooperatives of the Ministry of Economic Affairs and the Ministry of Economic Affairs ¾ According to the above test method evaluation, the pentacyclic triterpenes in the present invention are evaluated. Compared with the physiologically acceptable salts or derivatives of mature adipocytes for inhibiting fat accumulation, compared with the known CLA with anti-hypertrophic substances, for example, maslinic acid has about 2 to 20 times, and maslinate has about 2 to 20 times, cocadiol is about 2 to 20 times. Ursolic acid is about 2 to 18 times, ursitol is about 2 to 18 times, betulinic acid is about 2 to 18 times, and betulin is about 2 times. ~ 18 times, about 2 ~ 20 times of ethyl maslinate, about 2 ~ 20 times of acetylated maslinic acid, about 2 ~ 20 times of triethylsilyl maslinic acid, and about 2 ~ 20 times of stearic ethyl maslinate About 2 to 20 times 2 ~ 20 times, ethyl ursolic acid is about 2 ~ 20 times. The size of acetylated kumamoto paper is applicable to Chinese National Standard (CNS) A4 (210X297 mm) '~' -39-200300069 A7 B7 V. Description of the invention (Flat (please read the precautions on the back before filling out this page) The high maturity of fruit alcohol is about 2 to 18 times, that of ethyl betulinate is about 2 to 18 times, and that of acetated betulin is about 2 to 20 times. Function of inhibiting fat accumulation in type adipocytes. In other words, the anti-puffiness food of the present invention contains pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof, and thus has a more mature type than CLA. Inhibition of fat accumulation in adipocytes. Pentacyclic triterpenes and their derivatives with alcohol ester groups, derivatives with fatty acid ester groups, derivatives with alkoxy groups, derivatives with alkoxymethyl groups Since it is usually fat-soluble, it can be used in oil-based or emulsified foods. In addition, when ingested as an oil or fat processed product, it is expected to be absorbed together with the oil, and therefore, it is preferable from the viewpoint of absorbency. In addition, the physiologically acceptable salts or glycosides of pentacyclic triterpenes are usually water-soluble. Therefore, they can be used by dissolving and dispersing them in water-based or emulsified foods. In particular, foods are mostly water-based or emulsified products. Therefore, if necessary, pentacyclic triterpenes can be formulated and used as physiologically acceptable salts or saccharides. Printed by the Intellectual Property Department of the Ministry of Economic Affairs / I Bureau Consumer Cooperatives In addition, pentacyclic triterpenes and / or physiologically acceptable salts thereof can be formulated in trace amounts in tadpole foods to achieve the normally required anti-fullness function It is also beneficial in terms of cost. At the same time, from the point of view of the deployment ratio, there is also extra space to coordinate with other components, so it can also enrich other functions. Of course, by increasing the blending amount of pentacyclic triterpenes and / or physiologically acceptable salts thereof, the present invention can also produce loquat foods having excellent anti-puffiness functions and the like. The pentacyclic triterpenes in the present invention are known to exist in natural materials such as plants as described above. Almost all of the substances are passed through plants for human consumption. The paper size applies to the Chinese National Standard (CNS) A4 (210X29). * 7mm) " -40-200300069 A7 B7 V. Invention Description (3) Experience exists, so do n’t overdo it will not have adverse effects on the body. 0 In terms of actual animal administration, LD50 is more than 2000mg / kg body weight, it can be confirmed that it is extremely safe. This result shows that oral intake has the function of inhibiting the proliferation of precursor adipocytes, inhibiting the differentiation of precursor adipocytes, and inhibiting the accumulation of fat in mature adipocytes Pentacyclic triterpenes such as anti-puffiness function. In other words, they can be ingested through the form of glutinous food. In this case, unlike the administration of pharmaceuticals, the troubles or pains associated with them can continue. It can be easily ingested into the body. When used mainly for weight loss, the pentacyclic triterpenes of the present invention and physiologically acceptable salts or derivatives thereof can directly act on precursor lipids. Fat cells can be expected to have the lowest impact on the metabolism of other nutrients. In other words, for example, weight loss agents with lipolytic effects, the essential nutrients for the human body will also act in a direction that hinders their absorption, so in There are concerns about side effects, but the pentacyclic triterpenes and their physiologically acceptable salts or their derivatives in the present invention directly act on precursor adipocytes, so they can be said to have almost no blood lipids, blood glucose, etc. In this regard, the anti-fattiness food for foods of the present invention is also ideal from the viewpoint of safety because it can not lose weight under the condition of sufficient intake of nutrients. Symptoms, such as hypertrophy, hypertrophy, hypertrophy, hypertrophy, etc. The present invention contains pentacyclic triterpenes and their physiologically acceptable salts or their Select one or two or more of the derivatives to make a full-batter-resistant food. For this paper size, China National Standard (CNS) A4 (210X297 mm) CII (Please read first Note on the back page, please fill in this page) Order printed by the Ministry of Economic Affairs, Intellectual Property Bureau, Loan Workers and Consumer Cooperatives-41- 200300069 A7 B7 V. Invention Description (3¾ (Please read the note on the back page before filling out this page). The above "contains "Includes the meaning based on the ability to exhibit anti-hypertrophic function, and the intention to adjust the function of the production or increase of adipose tissue through the inhibition of proliferative adipocyte proliferation inhibition, differentiation inhibition, and fat accumulation inhibition In the case of the Consumer Cooperatives Cooperative of the Intellectual Property Office of the Ministry of Economic Affairs, the content of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof contained in the anti-fattiness food of the present invention may vary with the content The types of pentacyclic triterpenes, food types, intake, frequency, age, sex, weight, severity of symptoms, health status and other conditions vary and cannot be considered in one go. Of course, this content is a therapeutically effective content for the prevention of the production or proliferation of adipose tissue through the inhibition of proliferation, differentiation, and accumulation of fat in precursor-type adipocytes. In particular, in order to obtain the anti-fertilizing function of the present invention, the daily intake of pentacyclic triterpenes and their physiologically acceptable salts or derivatives thereof, such as maslinic acid, is usually 0. 001 ~ 5g range, with 0. 001 ~ lg is the best. Therefore, the content of pentacyclic triterpenes and their physiologically acceptable salts or their derivatives in the anti-fattiness food of the present invention, for example, at 0. 00001 ~ 90 mass% range, where 0. 0001 ~ 80 mass% is preferred, with 0. 001 ~ 70 mass% is better, and 0. 01 ~ 65 mass% is more preferable, and more preferably 0. 1 ~ 60 mass% is better, more preferably 0. 2 ~ 55 mass% is better, more preferably 0. 4 ~ 50 mass% is better, more preferably 0. 6 ~ 45 mass% is better, more preferably 0. 8 ~ 40 mass% is better, more preferably 1. 0 ~ 35 mass% is better, more preferably 2. 0 to 30% by mass is suitable. But it is not limited to the above range. In addition, when the active ingredient of the anti-puffiness food of the present invention contains pentacyclic triterpenes and the like contained in the active ingredient of the olive oil plant defatted product, the olive oil extract, or the olive oil extract, The content adjustment is within the above specified range. The Chinese national standard (CNS) A4 specification (210X297 mm) is applicable to this paper. -42-200300069 A7 B7 V. Description of the invention (3¾ is appropriate. (Please read the precautions on the back before filling in this Page) The anti-puffiness foods of the present invention are used as precursor-type adipocyte proliferation inhibiting components, precursor-type adipocyte differentiation inhibiting components, mature adipocyte fat accumulation inhibiting components, and pentacyclic triterpenes and When the physiologically acceptable salt or its derivative is used, its content depends on the type of pentacyclic triterpene, the type of food, intake, frequency, age, gender, weight, severity of symptoms, health status, etc. The conditions vary, and cannot be said in a nutshell. Of course, this content is an effective content for the inhibition of proliferation, differentiation, and fat accumulation of precursor adipocytes. This content As in zero. 00001 ~ 90 mass% range, where 0. 0001 ~ 80 mass% is appropriate, and 0. 001 ~ 70 mass% is more appropriate, and 0. 01 ~ 65 mass% is more preferable, and more preferably 0. 1 ~ 60 mass% is better, more preferably 0. 2 ~ 55 mass% is better, more preferably 0. 4 ~ 50 mass% is better, more preferably 0.6 ~ 45 mass%, more preferably 0. 8 ~ 40% by mass is better, more preferably 1. 0 ~ 35 mass% is better, especially 2. 0 to 30% by mass is suitable, but it is not limited to the above range. The characteristics of the anti-plumbitant glutinous food printed by the employees' cooperative of the 4th Bureau of the Ministry of Economic Affairs of the Ministry of Economic Affairs have the characteristics of inhibiting the proliferation of precursor adipocytes and inhibiting the differentiation of precursor adipocytes due to the inclusion of pentacyclic triterpenes, etc. , Anti-fatty function of mature fat cell fat accumulation inhibition function. Since it is in the form of ravioli, it is easy and can be continuously ingested, and a good effect is expected. In addition, the present invention is an oleanolane triterpene represented by the general formula (I) of the pentacyclic triterpenes, and an ursane triterpene represented by the general formula (II), III) It is related to the selection of one or two or more of the lupinane-type triterpenoids to be used for anti-fullness foods. Because of its anti-fat function, this paper standard is applicable to Chinese National Standard (CNS) A4 specification (21〇 × 29 * 7mm) -43-200300069 A7 ___B7_ V. Description of the invention (扃, and its precursor-type fat cell proliferation inhibiting function The anti-fatness function of the precursor-type adipocyte differentiation inhibition function and mature adipocyte fat accumulation inhibition function is suitable. The anti-obesity food of the present invention is used as an anti-fullness component and a precursor-type adipocyte When a proliferation-inhibiting component, a precursor-type adipocyte differentiation-inhibiting component, a mature-type adipocyte-fat accumulation-inhibiting component, and oleanolane-based triterpenes and / or physiologically acceptable salts and / or derivatives thereof are contained, Its content is the same as the foregoing regardless of the above, and is not limited to the following range, the content is, for example, 0. 00001 ~ 90 mass% range, where 0. 0001 ~ 80% by mass is preferable to 0. 001 ~ 70 mass% is better, and 0. 01 ~ 65 mass% is more preferable, and more preferably 0. 1 ~ 60 mass% is better, more preferably 0. 2 to 55% by mass is better, more preferably 0. 4 ~ 50 mass% is better, more preferably 0. 6 ~ 45 mass% is better, more preferably 0. 8 ~ 40 mass% is better, more preferably 1. 0 ~ 35 mass% is better, especially 2. 0 to 30% by mass is suitable. The anti-hypertrophic glutinous food of the present invention contains anti-hypertrophic components and precursor-type adipocyte proliferation inhibiting components, precursor-type adipocyte differentiation inhibiting components, mature adipocyte fat accumulation inhibiting components, and contains arbutane-based three In the case of terpenes and / or physiologically acceptable salts and / or derivatives thereof, the contents of terpenes and / or their physiologically acceptable salts and / or their derivatives are not limited to the foregoing, and are not limited to the following ranges. The content is e.g. 0. 00001 ~ 90 mass% range, where 0. 0001 ~ 80% by mass is preferable to 0. 001 ~ 70 mass% is better, and 0. 01 ~ 6 5 mass% is better, more preferably 0. 1 ~ 60 mass% is better, more preferably 0. 2 ~ 55 mass% is better, more preferably 0. 4 ~ 50 mass% is better, more preferably 0. 6 ~ 45 mass% is better, more preferably 0. 8 ~ 40 mass% is better, more preferably 1. 0 ~ 35 mass% is the standard of this paper. Applicable to China National Standard (CNS) A4 specification (210X297 mm) (Please read the precautions on the back before filling out this page) • Packing-Printed by the Intellectual Property Bureau, Ministry of Economic Affairs, Consumer Consumption Cooperative- 44-200300069 A7 __B7_ V. Description of the invention (4¾ is better, especially 2. 0 to 30% by mass is preferred. (Please read the precautions on the back before filling out this page) In the anti-puffiness food of the present invention, it is used as an anti-puffiness ingredient and a precursor fat cell proliferation inhibiting ingredient, a precursor adipocyte differentiation inhibiting ingredient, and mature fat. When the cell fat accumulation inhibiting component is contained in the lupinane triterpenes and / or physiologically acceptable salts and / or derivatives thereof, the content is as described above, and it is not limited to the following range. The content is e.g. 0. 00001 ~ 90 mass% range, where 0. 001 ~ 80% by mass is preferable to 0. 001 ~ 70 mass% is better, and 0. 01 ~ 65 mass% is more preferable, and more preferably 0. 1 ~ 60 mass% is better, more preferably 0. 2 ~ 55 mass% is better, more preferably 0. 4 ~ 50 mass% is better, more preferably 0. 6 ~ 45 mass% is better, more preferably 0. 8 ~ 40 mass% is better, more preferably 1. 0 ~ 35 mass% is better, especially 2. 0 to 30% by mass is preferred. As for the oleanolic triterpenes, maslinic acid and cocadiol are preferred, and maslinic acid is most preferred. As for the ursane triterpenes, ursolic acid and arsitol are preferred. In the case of lupines and triterpenes, betulinic acid and betulin are preferred. The Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed the anti-plumbing foods of the present invention as an anti-puffiness component and a precursor fat cell proliferation inhibiting component, a precursor fat cell differentiation inhibiting component, and mature fat cell fat accumulation. When the inhibitory ingredient contains maslinic acid and / or a physiologically acceptable salt or derivative thereof, the content thereof is as described above, and is not limited to the following range. The content is, for example, 0. 0000 1 ~ 90 mass% range, where 0. 0001 ~ 80 mass% is appropriate, and 0. 001 ~ 70 mass% is preferred, and 〇. 〇1 ~ 65% by mass is more preferable, and more preferably 0. 1 ~ 60 mass% is better, more preferably 0. 2 ~ 5 5 mass% is better, more preferably 0. 4 ~ 50 This paper size applies Chinese National Standard (CNS) A4 specification (210X297mm) -45-200300069 A7 B7 V. Description of invention (4i (Please read the precautions on the back before filling this page) Quality% is better And more to 0. 6 ~ 45 mass% is better, more preferably 0. 8 ~ 40 mass% is better, more preferably 1. 0 ~ 35 mass% is better, especially 2. 0-30% by mass is suitable. The anti-puffiness food of the present invention contains cocadiol and / or as an anti-puffiness component and a precursor-type adipocyte proliferation inhibiting component, a precursor-type adipocyte differentiation inhibiting component, and a mature adipocyte fat accumulation inhibiting component. In the case of physiologically acceptable salts or derivatives thereof, the contents of the salts or derivatives thereof are not limited to those described above, nor are they limited to the following ranges. The content is, for example, 0. 00001 ~ 90 mass% range, where 0. 0001 ~ 70 mass% is suitable, and 0. 001 ~ 60 mass% is better, and 0. 01 ~ 50% by mass is more preferable, and more preferably 0. 1 ~ 40 mass% is better, especially 1. 0 to 30% by mass is preferred. The Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed the anti-plumbing foods of the present invention as an anti-puffiness component and a precursor fat cell proliferation inhibiting component, a precursor fat cell differentiation inhibiting component, and mature fat cell fat accumulation. When the inhibitory ingredient contains ursolic acid and / or a physiologically acceptable salt or a derivative thereof, the content is not the same as that described above, nor is it limited to the following range. The content is, for example, 0. 00001 ~ 90 mass% range, where 0. 0001 ~ 70 mass% is suitable, and 0. 001 ~ 60 mass% is better, with 0. 01 ~ 50% by mass is more preferable, and more preferably 0. 1 ~ 40 mass% is better, especially 1. 0 to 30% by mass is preferred. The gluten-resistant food for anti-fullness of the present invention contains arbutanol and / or as an anti-fullness component and a precursor-type adipocyte proliferation inhibiting component, a precursor-type adipocyte differentiation inhibiting component, and a mature adipocyte fat accumulation inhibiting component. In the case of physiologically acceptable salts or their derivatives, the content is not the same as the foregoing, nor is it limited to the following range. The content is, for example, the Chinese national standard (CNS) A4 specification (210X297 mm) applicable to this paper size. • 46 200300069 A7 B7 V. Description of the invention (flat (please read the precautions on the back before filling this page) 0. 00001 ~ 90 mass% range, where 0. 0001 ~ 70 mass% is suitable, and 0. 00 卜 60 Mass% is better, and 0. 01 to 50% by mass is more preferable, and more preferably 0. 1 ~ 40 mass% is better, especially 1. 0 to 30% by mass is preferred. The fermented food for preventing fullness of the present invention contains betulinic acid and / or it as an anti-fullness component and a precursor-type adipocyte proliferation inhibition component, a precursor-type adipocyte differentiation inhibition component, and a mature adipocyte fat accumulation inhibition component. In the case of physiologically acceptable salts or their derivatives, the content is not the same as the foregoing, nor is it limited to the following range. The content is, for example, at 0. 00001 ~ 90 mass% is preferred, with 0. 0001 ~ 70 mass% is appropriate, and 0. 001 ~ 60 mass% is better, and 0. 01 ~ 50% by mass is more preferable, and more preferably 0. : 1 ~ 40% by mass is better, especially 1. 0 to 30% by mass is preferred. The Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs printed the anti-plumbing foods of the present invention as an anti-puffiness component and a precursor fat cell proliferation inhibiting component, a precursor fat cell differentiation inhibiting component, and mature fat cell fat accumulation. When the inhibitory ingredient contains betulin and / or a physiologically acceptable salt or derivative thereof, the content is not the same as that described above, nor is it limited to the following range. The content is, for example, at 0. 0000 1 ~ 90% by mass is preferred, with 0. 0001 ~ 70 mass% is appropriate, and 0. 001 ~ 60 mass% is better, and 0. 01 to 50% by mass is more preferred, and more preferably from 0.1 to 40% by mass, especially 1. 0 to 30% by mass is preferred. The higher the above content, the better the effect, but as mentioned above, it is necessary to adjust its content according to considerations such as the purpose of use, the period of use, the amount of use, the age of the target, sex, weight, etc. The fermented foods for preventing fullness of the present invention include the following specific examples, but they are not limited to the following ranges and need not be explained. The scale-proof paper of the present invention is suitable for Chinese paper (CNS) A4 (210X297 mm) -47-200300069 A7 B7 V. Description of the invention (4 乂 (Please read the precautions on the back first) (Fill in this page again.) There is no special restriction on the printing status of the employees ’cooperatives of the Jijilang Wisdom and Finance Bureau. For example, in addition to general foods and processed foods, such as mobile food ρα, nutritional foods for health, health foods, foods for infants and young children. Isoform bears can be included. Specifically, such as senbei, pancakes, popcorn, Japanese desserts such as glutinous rice crackers, biscuits, cookies, crackers, pie cakes, donuts, puddings, Sponge cake, quiche, cream, whipped cream, puff, jacket power, jacket power biscuits, milk, candy, chewing gum, jelly wafers, bread, steamed bread and other European and American desserts; potato chips and other instant desserts , Ice cream, popsicles, frost, and other chestnuts; lactic acid sauce, lactic acid bacteria sauce, thick milky sauce, juice sauce, pulp sauce, functional sauce, carbonated sauce and other cool sauces; green tea Black tea, coffee, cocoa and other hobby products and their condiments, fermented milk, processed milk, cheese and other dairy products; soy milk, ugly and other soy processed foods; jam, fruit sugar, flower sauce, peanut butter, fruit paste and other pastes; Sauces; Udon, Buster and other meat products; ham, sausage, cured smoked pork, dry sausage, beef jerky, burger and other meat products; fish ham, fish sausage, plate fish, bamboo wheel, fried fish paste and other fish and shellfish Products; dried products such as fish, shellfish, bonito, mackerel, bonito, etc .; sea urchin, small mullet and other _ pickles; squid and other fish _ dried, salmon and other smoked fish products; nori; small Canned foods such as fish, shellfish, mountain vegetables, shiitake mushrooms, kumbu, curry, braised beef; Japanese watercress, soy sauce, sauce, gravy, dipping sauce, curry sauce, braised beef seasoning, soup, umami Seasonings; rice; oil or margarine, butter, buttermilk, lettuce sauce and other processed fats, or various microwave foods or frozen foods containing oil and fat. In terms of continued intake, rice Or various seasonings Blended with oil or margarine, butter, buttermilk, lettuce, etc. is better blended with processed oil and ester products. Also, ^ Paper size applies Chinese National Standard (CNS) A4 Washing (210X297 mm) " "- 48-200300069 A7 B7 V. Description of the invention (4 & (Please read the notes on the back before filling in this page) There is no special restriction on its shape and properties. Solid, semi-solid, gel, liquid, powder Anything can be done, and any dosage form such as tablets, capsules, liquids, granules, etc. can be used. Printed by the Consumer Cooperative of the 4th Bureau of the Ministry of Economic Affairs and the Intellectual Property Cooperative, as mentioned above, the present invention is one of Pentacyclic triterpenes, the physiologically acceptable salt or its derivative content, with a daily intake of 0. 001 ~ 5g, especially at 0. 001 ~ lg range is the best. More specifically, when the fermented foods for preventing obesity of the present invention are formulated with processed fats and oils such as oil or margarine, ghee, beauty milk, and lettuce, the pentacyclic triterpenes contained in the foods of the present invention Alkenes, especially maslinic acid, the physiologically acceptable salts or derivatives thereof contain 0. 001 ~ 10g is suitable, in which 0 · 01 ~ 5g is preferred, and 0. 1 to 3 g is more preferred, and 0.2 to 2 g is particularly preferred. When the loquat food for anti-fullness of the present invention is loquat fruit, soft capsule food, lozenge food, powdered food, granular food, the pentacyclic triterpene contained in the loquat food in the present invention, especially The content of maslinic acid, its physiologically acceptable salts or its derivatives is based on 500 mg of the product, preferably 1 to 400 mg, and more preferably 5 to 380 mg. The anti-fattiness foods used in the present invention are foods, healthy foods, milky foods, fruit juices, pulp foods, and teas. Coffee, alcoholic condiments, pentacyclic triterpenes contained in the loquat food of the present invention, especially maslinic acid, the physiologically acceptable salt or its derivative content is based on the product 200g, to contain 0. 002 ~ 10g is suitable, in which 0. 02 ~ 5g is more preferable. In addition, in order to improve the function of the fermented food for preventing fullness of the present invention, other physiologically active ingredients may be blended for the purpose of achieving the synergistic effect, auxiliary effect, and improvement of absorbency of the fullness of the function of fullness. There is no special @ system mentioned above. For example, the paper size that is considered to have a synergistic or indirect contribution to the anti-fullness function is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) -49- ¢ Cooperative cooperative seal 200300069 A7 B7 V. Description of the invention (46) Antioxidant ingredients, oily ingredients that enhance the absorption efficiency in the body, and various vitamins for nutritional purposes. Minerals, amino acids, etc. are available. The above antioxidant components are not particularly limited, such as lignans such as tocopherols and derivatives thereof, tocotrienols and derivatives, sesamin, episesamin, sesamin, sesamin, sesamol, etc. And its glycosides, carotenoids and derivatives thereof such as / 3-carotene and tannins and derivatives thereof such as gallic acid or ellagic acid, flavones, catechin , Flavonoids, such as flavonoids, colorless anthocyanins, ubiquitin or vitamin K, ferulic acid derivatives such as glutenin, olive extract, etc. The above-mentioned antioxidants are considered to have indirect anti-puffiness function, and, by virtue of the original anti-oxidant effect, promote blood circulation function or anti-aging function, etc., it is expected to have a comprehensive synergistic effect on the body. Examples of the above oily ingredients include vegetable oils such as sesame oil, olive oil, tea oil, and animal oils such as fish oil, and are not particularly limited. For example, MCT, MLCT, and diglycerides obtained by natural and chemical reactions or enzyme reactions, A monoglyceride or a structured oil or fat is obtained by designing the structure of a fatty acid. Although there are no particular restrictions on the various vitamins, minerals, amino acids, etc. used in the above fortified nutrition, it is advisable to use those specified in the Standard Manual for Food Additives. In addition, the fermented foods for preventing fullness of the present invention can also be prepared by using materials used in general fermented foods. Although, there are no particular restrictions, such as Japanese bean paste, soy sauce, western sauce, gravy, dipping sauce, curry sauce, braised beef sauce, soup, umami and other seasonings, lard, butter, Animal fats such as milk fat, residual oil, amaranth oil, amaranth oil and other aquatic oils and fats, soybean oil, this paper size applies Chinese National Standards (CNS) (21GX297 male | --- -50- (Please read the precautions on the back first (Fill in this page again)

200300069 A7 __B7 _ V. Description of the invention (4 (Please read the notes on the back before filling this page) Rapeseed oil, cottonseed oil, rice bran oil, corn oil, sesame oil, peanut oil, Xiang Yue sunflower oil, safflower oil, tea oil Olive oil, linseed oil, tung oil, ramie seed oil, coconut oil, palm oil, cocoa butter, and other vegetable oils can be used. Among them, olive oil is particularly suitable because it contains maslinic acid in the present invention. The pentacyclic triterpenes in the food for preventing fullness of the present invention are mostly oil-soluble substances. Therefore, in terms of solubility, the food for preventing fullness of the present invention is processed with fat or oil The above-mentioned oils and fats are not particularly limited. For example, natural or synthetic pentacyclic triterpenes are dissolved in general oils and fats, or the extraction and extraction conditions of plant seeds are adjusted to make the pentacyclic rings of seeds. Triterpenoids can be used at high concentrations in oils extracted from extracted oil, or oils made from pentacyclic triterpenes contained in the oil can be adjusted by adjusting the refining conditions. Also, The pentacyclic triterpenes High-content olefinic fats and oils and their mixed fats can also be used. At this time, the synergy between the physiologically active functions of the trace ingredients contained in the other fats mentioned above can be expected. Sexual triterpenes can be obtained from oil-derived plants. Therefore, in terms of production, the oleyl ester can be said to be more suitable. Furthermore, the processed fats and oils such as margarine, ghee, beauty milk, and lettuce are better. According to the 2001 Japanese National Nutrition Survey report, the fat contained in food materials accounted for 76% of the total fat intake, and fat products such as edible oil or margarine or butter were used. The ratio of fat intake is 24%. In other words, the total fat mass ingested by the human body in an average of about 60g, the paper size of the oil ingested from oil and fat products applies the Chinese National Standard (CNS) A4 specification (210X297 mm) '~ -51- 200300069 A7 ___B7 _____ 5. Description of the invention (flat (please read the precautions on the back before filling out this page) The fat weight is only about 14.4g. This amount accounts for the total intake of the human body in a day The amount of food (average about 1400g, refer to the "Food and Supply Table of Food and Demand" of the Ministry of Agriculture, Forestry and Fisheries of Japan) is only about 1%. When considering the above question, in the general food habits, you want to use the oil of the present invention to obtain the anti-puffiness function of the invention At the time, the most suitable amount of pentacyclic triterpenes and physiologically acceptable salts in edible oil, salad oil, margarine, butter and other fats and oil products is 0.0001-20% by mass, of which 0.0002 ~ 18% by mass is preferred, and 0.0005 ~ 16% by mass is more preferred, 0.001 ~ 14% by mass is more preferred, 0.002 ~ 12% by mass is more preferred, and 0.005 ~ 10% by mass is more preferred. Better, more preferably 0.01 to 8% by mass, more preferably 0.02 to 6% by mass, still more preferably 0.05 to 4% by mass, still more preferably 0.1 to 3% by mass, especially 0.2 ~ 2% by mass is optimal. Similarly, products using the oils and fats contained in the present invention are also suitable. The above "use" refers to the use as raw materials and the use of fats and oils in fried or fried products, both of which are included. The above is used as a raw material for printing by the consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, which refers to, for example, the use of oils containing the pentacyclic triterpenes and the like as raw materials in the above-mentioned various foods, which has become the present invention. The anti-plump foods are made with coriander. In this case, oils and fats containing pentacyclic triterpenes and the like can be used in the same way as oils and fats that are generally used. Therefore, it is not necessary to specifically change the manufacturing process of the food, and it is ideal to simply obtain the food of the present invention. . In addition, the above-mentioned use as fats and oils refers to generally known methods of using fats and oils, and is not particularly limited, such as frying oils, frying oils, solid fats and oils, and the like. In this case, the above-mentioned fats and oils containing pentacyclic triterpenes and the like are used for frying or frying, and the fried or fried products are made to this paper. The standard of this paper applies to the Chinese National Standard (CNS) A4 (210X297). -52-200300069 A7 B7 V. Description of the invention (扃 (Please read the precautions on the back before filling out this page) etc. as the anti-fat food of the present invention. The above usage method should be in the food of the purpose The pentacyclic triterpenes of the present invention are not particularly limited by adding, attaching, containing, etc. The pentacyclic triterpenes used in the above-mentioned foods are not particularly limited, but they are used in oily foods. Pentacyclic triterpenes or derivatives containing alcohol ester groups, derivatives containing fatty acid ester groups, derivatives containing alkoxy groups, derivatives containing alkoxymethyl groups are preferred Because these are relatively oil-soluble, they are very suitable for the use of oil-based foods. Of course, pentacyclic triterpenes can also use physiologically acceptable salts or glycosides. In this case, add An emulsifier is preferred. In addition, generally For water-based foods, it is better to use physiologically acceptable salts or glycosides of pentacyclic triterpenes. Because they are relatively water-soluble, they are suitable for water-based foods. Of course, five The cyclic triterpenes or their derivatives are preferably added with an emulsifier. The pentacyclic triterpenes and their physiologically acceptable salts, or their derivatives, are suitable for the anti-puffiness of the present invention. The gluten-containing food can be used as its raw material. In other words, the above-mentioned fertility-resistant glutinous food can be used as one of its raw materials. In this case, pentacyclic triterpenes and their physiologically acceptable There are no particular restrictions on the origin of salts or their derivatives. They can be obtained from natural or synthetic sources, but the higher the purity, the better. The benefits of high purity, in addition to greatly improving the anti-puffiness function, It has the advantage of removing impurities, etc. In other words, it can avoid the danger of unpredictable side effects caused by impurities or the trouble that can't be predicted when making anti-plump foods. It is also more convenient in operation. Contributes to quality and other advantages This paper size applies Chinese National Standard (CNS) A4 specifications (210X297 mm) • 53-200300069 A7 ____B7 V. Description of the invention (5¾ (Please read the precautions on the back before filling this page) There are many Therefore, it is better to use the higher purity. In addition, when the purity is improved by separation, refining, etc., the pentacyclic triterpenes in the present invention and their physiologically acceptable salts or their derivatives are usually It is obtained by white or colorless solid, semi-solid, liquid, etc., so it has the advantage of being suitable for the anti-fattiness foods of the present invention without additional coloring.飮 Foods can absorb pentacyclic triterpenes and their physiologically tolerable salts or their derivatives into the body to achieve their effects. Since it is in the form of ravioli, it does not require labor as if using cosmetics, and it is ideal to continue ingestion. The pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof contained in the food for preventing obesity in the present invention, by ingestion, are expected to obtain an appropriate amount of anti- plumping function as described above with ingestion The form, gender of the user, weight, body condition, etc. vary, and there are no particular restrictions. For example, it is usually 0.0000 g / day or more, with 0.01 g / day or more being preferred, and 0.1 g / day or more being more preferred. More preferably, it is more preferably 0.2 g / day or more, more preferably 0.5 g / day or more, even more preferably 0.7 g / day or more, and most preferably 1.0 g / day or more. These pentacyclic triterpenes can be extracted from naturally occurring plants, degreased matter of the olive plant, and the like, respectively. That is, water and / or organic solvents are used to extract from each plant body, and then the solvent extraction method is used, which uses the difference in solubility with impurities, separation precipitation method, recrystallization method, ion exchange resin method, liquid chromatography method, etc. Or appropriate combination, or repeated use. Concentration and / or fractionation • Refining. Re-single-separators are most suitable because they do not allow foods of the invention to have extra color and taste. This paper size 14 is used for towels and household materials (€ 8 and 4 secrets (21 (^ 297 mm) " -54-200300069 A7 B7) 5. Description of the invention (5¾ (Please read the precautions on the back before filling this page) In particular, maslinic acid and / or physiologically acceptable salts thereof can be extracted from olive oil plants and degreased matter of olive oil plants with water and / or organic solvents, and the solvent extraction method can be combined or reused separately or appropriately. , Using the difference in solubility with impurities, separation precipitation method, recrystallization method, ion exchange resin, liquid chromatography, etc. alone or appropriately combined, or repeated use for fractionation and purification, and can be isolated from the extract Isolation and refinement. The olive plant (olea europaea L.) can be used by anyone who eats or squeezes oil from Japan, Europe, etc. The maslinic acid and / or this contained in the anti-plump food of the present invention The physiologically tolerable salts are mainly natural olive olive plants, obtained from their fruits or seeds, and can also be obtained from their seed bark, leaves, stems, and buds. Also, they can be obtained from such dried matter , Crushed material, degreasing Appropriately obtained. Among them, self-defatted fruits (including peels) or dried and pulverized pieces of the peels are suitable. In addition, by-products generated in the olive oil manufacturing steps, such as crushing residues, extraction residues, and oil extraction residues , Pressed oil, extracts, degummed oil residues, deacidified oil residues, dark brown oil, waste decolorant, deodorizing scum, squeezed juice, waste water, and filtration waste. Among them, oil extraction residues and extraction residues are appropriate. Ministry of Economic Affairs Printed by the Consumer Finance Cooperative of the Intellectual Property Office, when the water of the above olive oil plants or their degreased matter is added with water, or when steaming or humidification is performed, the fruits of these olive oil plants or their degreased matter It will moderately swell and increase its extraction efficiency, so it is extremely suitable. In addition, the olive extract referred to in this specification refers to the extract obtained by the solvent extraction of the defatted product obtained in the step of manufacturing olive oil, and obtained in the step of manufacturing olive oil. The degreasing system includes extraction residues and compression residues. In addition, in the present specification, the olive oil extract refers to a paper scale obtained from the pressure I obtained in the olive oil production step. Applicable to Chinese National Standard (CNS) A4 specification (210X297 mm 1 -55-200300069 A7 B7) V. Description of the invention (d. For the extraction oil obtained by squeezing the residue and then extracting it with hexane and other solvents. (Please read the precautions on the back first) (Please fill in this page again) In particular, the degreased substances of the olive plant contain high concentrations of maslinic acid and / or its physiologically acceptable salts, and it is not necessary to remove oil from maslinic acid and / or its physiologically acceptable salts. The degreased product can be made from olive oil press residue produced in the edible oil refining step, or the residue extracted through hexane as a raw material. In addition, hydrocarbons such as pentane, hexane, and heptane, and acetic acid are used as raw materials. One or two or more non-water-soluble organic solvents such as ethyl esters of lower fatty acids, diethyl ether and the like are used to extract and remove the lipid components contained in the olive oil plant or the degreased matter, and then repeat the washing and degreasing treatment as necessary. Things can also be fully utilized. Extraction from the above olive plant with water and / or organic solvent can also obtain maslinic acid and / or physiologically acceptable salts thereof contained in the anti-fattiness food of the invention. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ¾ The organic solvent used to obtain maslinic acid and / or physiologically acceptable salts from olive plants can be either a hydrophilic organic solvent or a hydrophobic organic solvent. Specifically, the hydrophilic organic solvent may be alcohols such as methanol, ethanol, glycerin, propylene glycol, and 1,3-butanediol, acetone, tetrahydrofuran, acetonitrile, 1,4-dioxane, pyridine, dimethylasyl, N, Well-known organic solvents and hydrophobic organic solvents such as N-dimethylformamide and acetic acid may be hexane, cyclohexane, carbon tetrachloride, chloroform, dichloromethane, 1,2 · dichloroethane, and Well-known organic solvents such as ethanol, ethyl acetate, benzene, and toluene. These organic solvents may be used singly or in combination of two or more kinds. Industrially speaking, for example, in terms of permeability to plant tissues and extraction efficiency, the use of hydrophilic organic solvents is appropriate, and the use of water-containing hydrophilicity is in accordance with the Chinese National Standard (CNS) A4 specification (210X29 * 7) Mm) -56-200300069 A7 ___ B7_ 5. Description of the invention (5¾ (Please read the notes on the back before filling this page) Organic solvents are suitable, specifically methanol, ethanol, glycerol, propylene glycol, 1, 3- Alcohols such as butanediol, organic solvents such as acetone, tetrahydrofuran, and acetonitrile, and these aqueous solvents. One or two or more kinds of these solvents can be selected from the olive oil plant to obtain the fertility-resistant fermented food of the present invention The maslinic acid and / or physiologically acceptable salts thereof contained in the extract. The extraction conditions are not particularly limited, but may be at a temperature of 5 ° C to 95 ° C, preferably 10 ° C to 90 ° C, more preferably It is 15 ° C ~ 85 ° C, and can be fully extracted at normal temperature. When the temperature is high, there is a tendency to improve the extraction efficiency. The pressure is normal pressure or pressure, or reduced pressure such as adsorption can also fully extract. Also, in order to improve the extraction efficiency, Can also be extracted by shaking, or equipped with a mixer, etc. The extraction machine extracts. The extraction time varies depending on other extraction conditions, usually several minutes to several hours. The longer the time, the more sufficient the extraction can be, but it can still be appropriately determined according to production conditions such as production equipment and yield. The solvent used in the extraction is water alone, organic solvents alone, and mixed use of water and organic solvents can be 1 to 100 times the amount of the raw materials (the following are all mass / mass), preferably 1 to 20 times Printed by the Consumers ’Cooperative of the Ministry of Economic Affairs and the Bureau of the Ministry of Economic Affairs. When considering the safety of the human body, etc., it is particularly preferable to use any of water, water-containing lower alcohols, and anhydrous lower alcohols for extraction. In addition, consider When the yield of the obtained maslinic acid and / or its physiologically acceptable salt, or the strength of the anti-puffiness effect, it is preferable to extract the aqueous lower alcohol with a lower alcohol content of 10% by mass or more. It is more preferable to use a lower alcohol content The water-containing alcohol is preferably 10% by mass to 95% by mass, and most preferably, the water-containing lower alcohol having a lower alcohol content of 30% to 95% by mass is adjusted. Here, the alcohol-based methanol used in the present invention is Ethanol, 1-propanol, 1-butanol scale applies this paper China National Standard (CNS) A4 size (210X297 mm) -57 - 200300069 A7 B7

V. Description of the invention (A (please read the precautions on the back before filling this page) and other primary alcohols, secondary alcohols such as 2-propanol, 2-butanol, and tertiary alcohols such as 2-methyl-2-propanol Alcohols can be solvents such as ethylene glycol, propylene glycol, 1,3-butanediol and other liquid polyols, and these solvents can be used alone or in combination of two or more. Lower alcohols can be C! ~ C4 well-known alcohols For example, one of the above, second, third, or liquid polyols, etc., these can be used alone or in combination of two or more. In addition, when the present invention is a glutinous food, the lower alcohol is preferably ethanol, and the content is 10 Extraction of hydrous ethanol with mass% or more is preferable. It is more preferable to use 10% to 95% by mass of water-containing ethanol, and it is best to prepare 30% to 95% by mass of water-containing ethanol. The crude extract thus obtained And / or the crude extract, and the maslinic acid and / or physiologically acceptable salts thereof in the present invention can be obtained by removing the solvent and water. The solvent and water can be removed by vacuum distillation, vacuum, and vacuum. Known methods such as drying, freeze-drying, spray-drying, etc. It is not particularly limited including water. Since the extract obtained from the degreased product does not contain oil-soluble components such as triglycerides or fatty alcohols, tocopherols, it is not necessary to remove and refine these, so it is better. It is printed by the bone-eliminating cooperative of the staff of the property bureau. Since the fat-removing material contains residues after pressing, the pressing residues (pressing residues) and extraction residues (extracting residues) of olive oil can be used. The effective utilization method is usually used by those who are discarded or used in feed, so it is also an excellent method in terms of production cost. In addition, to enhance the maslinic acid and / or its physiologically acceptable extract from the olive plant The anti-fullness effect of the permitted salt is preferably maslinic acid such as concentrated scent and / or its physiologically acceptable salt is included in the anti-fullness of the present invention. The paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm) -58-200300069 A7 B7 V. Description of the invention (々 用 飮 食品. (Please read the notes on the back before filling out this page) The concentration conditions are not particularly limited, but you can use them Method for the solubility of water. The maslinic acid and / or physiologically acceptable salts thereof contained in the anti-plumid foods of the present invention have low polarity and are insoluble compounds. Using this property, they will be derived from olives. The crude extract obtained from plants is divided into a water-insoluble component and / or a water-insoluble component, that is, it is divided into a water-insoluble component and the water-soluble component, thereby being more concentrated. The crude extract of the plant contains insoluble water and other components that are superior in anti-fatness effect compared with the whole olive olive plant extract, so it can be confirmed that maslinic acid and / or its physiological tolerance is allowed The salt has been concentrated. Water-insoluble ingredients can be obtained by adding water to the crude olive olive extract, stirring it, filtering out the precipitated part, etc., and then simply obtaining the staff of the Ministry of Economic Affairs, Smart Finance 1 Bureau Consumption cooperatives ¾ In addition, the maslinic acid and / or physiologically acceptable salts thereof contained in the anti-fattiness food of the present invention can be concentrated by liquid-liquid separation by combining ordinary solvents as required. The combination of solvents is difficult to specify at one stroke, but it can be combined with water-hydrophobic organic solvents, for example, hexane, carbon tetrachloride, chloroform, dichloromethane, 1,2-dichloroethane, and Well-known solvents such as diethyl ether, ethyl acetate, n-butanol, benzene, and toluene. Among them, hexane, ethyl acetate, and n-butanol are suitable. The maslinic acid and / or physiologically acceptable salts are those which are poorly water-soluble, and the water-soluble components that are not used can be removed when the hydrophobic organic solvent is separated from the phase. Removal of the solvent makes it extremely easy to concentrate maslinic acid and / or its physiologically acceptable salts. This paper size applies to Chinese National Standard (CNS) A4 (210X297 mm) -59- 200300069 A7 B7 V. Description of the invention (5¾ (Please read the notes on the back before filling this page) In addition, the invention is suitable for anti-fullness山 The maslinic acid and / or physiologically acceptable salts thereof contained in the food are preferably fractionated and refined from the above-mentioned extracts and / or concentrates, so that they can be concentrated and separated from the intended ingredients. The advantages of fractionation and refining are that in addition to increasing the melanin production inhibitor, impurities can also be removed. That is, when fractionating and refining, it can be used as white crystals to obtain maslinic acid and / or physiologically acceptable salts thereof. Therefore, it will not add unused colors to the food when it is used, which is very suitable for coordination. It is its advantage and it is ideal. The method of printing, fractionating and refining processing by the employee consumer cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs is difficult.槪 stipulated, but for example, the recrystallization method, ion precipitation method, chromatography method, etc. can be used. In particular, the method using liquid chromatography in chromatography is not to decompose the anti-fatness of the present invention.山 The maslinic acid and / or physiologically acceptable salts contained in the food are ideally fractionated and refined in excellent yield. Liquid chromatography is specifically cis-phase liquid chromatography and reverse-phase liquid Chromatography, thin-layer chromatography, paper chromatography, high-speed liquid chromatography (HPLC), etc., fractionate and purify the maslinic acid and / or physiologically acceptable salts thereof contained in the anti-fattiness food of the present invention Any of these methods can be used. In particular, in consideration of separation capacity, throughput, and number of steps, it is preferable to use reverse phase chromatography and high-speed liquid chromatography (HPLC). This means, for example, the following methods: that is, for example, using silica gel as a stationary phase, a hexane-ethyl acetate mixed solution, a chloroform-methanol mixed solution, and the like as a mobile phase column, and the supply rate is 0.1 to 5% (mass / volume). The crude extract from maslinic acid or its concentrate is subjected to continuous dissolution by a single mobile phase or stepwise dissolution method of sequentially increasing the polarity of the solvent, so that the predetermined fraction is dissolved in accordance with Chinese national standards. (CNS) A4 size (210X297 mm) -60-200300069 A7 __B7__ 5. Description of the invention (Separation method. (Please read the precautions on the back before filling out this page) Reverse phase liquid chromatography refers to the following methods, for example, to produce octadecylsilane-bound silica (ODS ) Is a stationary phase, and a water-methanol mixed solution, a water-acetonitrile mixed solution, and a water-acetone mixed solution are used as a mobile phase column, and a crude extract from maslinic acid is supplied at a concentration of 0.1 to 50% ((mass / volume)). Or its concentrate, a method of continuous dissolution of a single solvent or a stepwise dissolution method of sequentially reducing the polarity of the solvent to dissolve a predetermined fraction. High-speed liquid chromatography (HPLC) is in principle the same as the above-mentioned cis-phase liquid layer Those who have the same analytical or reverse-phase liquid chromatography, and perform fractionation and purification with faster and higher separation ability. One or a combination of two or more of the above methods can significantly concentrate maslinic acid and / or physiologically acceptable salts thereof, and obtain them in a state where impurities are removed, so it is highly desirable. In addition, the purity of maslinic acid and / or physiologically acceptable salts thereof can be adjusted by one method or a combination of two methods, and the strength and characteristics of melanin production inhibitory effect can be designed as required. Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs ¾ The above-mentioned concentration treatment is preferably repeated concentration treatment, and different concentration treatments can be combined. Similarly, the fractionation and refining treatments are preferably repeated fractionation and refining treatments, and different fractionation and refining treatments can be combined. After the concentration treatment is applied, fractionation, refining treatment, or fractionation, refining treatment, and fractionation, refining treatment may be applied, and after concentration treatment, fractionation, refining treatment, and concentration treatment may be performed. Of course, combinations other than the above combinations can also be used. 〇 The extraction treatment, concentration treatment, and fractionation described above in various combinations ^ The paper size applies the Chinese National Standard (CNS) A4 specification (210 × 297 mm) -61-200300069 A7 B7 V. Description of the invention (Β (please read the notes on the back before filling this page) and / or refined treatment, which is very suitable for obtaining maslinic acid and / or physiologically acceptable salts. The combination is not particularly limited, only A specific example of the treatment may be the following method. For example, after extracting and treating the olive plant with water and / or a hydrophilic organic solvent, a part or all of the hydrophilic organic solvent is removed from the obtained extract, and water is added as required to stir. The insoluble water component precipitated in the recovered water layer portion is concentrated. The precipitated insoluble water component can be recovered by filtration or centrifugation. In order to improve the recovery efficiency, water is added to the aqueous solution and stirred as needed. The water-extracted and / or hydrophilic organic solvent-extracted dry extract obtained may be added with water and stirred in the same manner as described above. After the treatment, the insoluble water component can be recovered by filtration and concentrated. This concentration method is a treatment under the water system, so it is safer than using a solvent to concentrate, and the range of machines that can be used is also wider. Also, Because it contains almost no oil, the efficiency of concentration and refining is also excellent and ideal. It is printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs for fractional distillation and refining during cis-phase and / or reverse-phase chromatography and / or recrystallization When these concentrates are processed, they can be purified very smoothly into high-purity maslinic acid and / or physiologically acceptable salts thereof, and even more isolated. Here, the amount of water added during liquid-liquid separation The amount is not particularly limited as long as it is a separable amount, but in terms of the mass of the dried extract per unit, the amount is preferably 1 to 100 times, more preferably 5 to 50 times, and the best is 10 to The amount is about 30 times. In the liquid-liquid separation of water-hydrophobic organic solvents, water and hydrophobic organic solvents are preferably water: hydrophobic organic solvents of 1 to 1: 9 (volume ratio). This paper Standards apply to Chinese National Standard (CNS) Α4 regulations (210X297 mm) -62- 200300069 A7 B7 V. Description of the invention (8: 2 ~ 2: 8 for the better). (Please read the precautions on the back before filling out this page). The total content of maslinic acid and / or physiologically tolerable salt in a mixture of maslinic acid and physiologically tolerable salt obtained from the product obtained from the olive oil production step is preferably 95% or more, and more preferably 95% to 99.99%. This content can be measured, for example, by chromatography. In addition, the hydrophilic organic solvent is removed from the extract obtained from the olive oil, and the remaining aqueous solution is optionally added with water, and then a hydrophobic organic solvent can be added. Liquid-liquid separation of water-hydrophobic organic solvents is concentrated. In addition, water can also be added to the extracts in the dry solid state, and then hydrophobic organic solvents can be added to borrow water-hydrophobic organic solvents. Separated and concentrated. Fractionation and purification by cis-phase and / or reverse-phase chromatography and / or recrystallization can obtain crude maslinic acid and / or physiologically acceptable salts thereof. Printed by the Consumers' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs of the present invention, the anti-plumbing foods containing maslinic acid and / or physiologically acceptable salts thereof, but containing maslinic acid and / or physiologically acceptable salts thereof Salts can also be obtained by using the above-mentioned extracts, concentrates, separation / refined products, pure isolates, etc., for the anti-fat foods of the present invention. In addition, by adjusting the degree of concentration, separation, and refining, the concentration of maslinic acid and / or physiologically acceptable salts thereof can be adjusted, and it can be adjusted and blended in the food. In addition, other anti-fertilizing substances can be blended and used to design the anti-fertilizing function in detail, and the anti-fertilizing function can be greatly enhanced by the synergistic effect with other anti-fertilizing substances. Since olive oil contains maslinic acid, using the olive oil as an oily ingredient in the anti-fattiness food of the present invention can obtain a very suitable paper size applicable to the Chinese National Standard (CNS) A4 specification (210X297 1-63-200300069 mm Α7 Β7 V. Description of the invention (βί) Anti-fatness effect is extremely ideal. (Please read the precautions on the back before filling this page) Also, extract maslinic acid from olive and / Or its physiologically acceptable salt is also extracted with oleic acid and / or its physiologically acceptable salt, but oleic acid and / or its physiologically acceptable salt is related to hawthorn The acid has good mutual solubility, so these mixtures can be directly used in the anti-plump foods of the present invention. By this, it can be expected that the physiological effects of the synergistic effects will be multiplied, especially the maslinic acid and / or its physiology The salt that can be tolerated in the present invention exerts a multiplying effect on the effect of anti-puffiness, so it is very ideal. It can be adjusted when it is extracted from the olive plant and isolated and refined maslinic acid and / or its physiologically tolerable salt. The conditions are sufficient Mixtures with oleic acid and / or physiologically acceptable salts thereof, and oleic acid and / or physiologically acceptable salts thereof may be isolated from olives, respectively. Permissible salts can be obtained by mixing. It can also be maslinic acid and / or physiologically acceptable salts thereof obtained from different raw materials, and oleic acid and / or physiologically acceptable salts thereof. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. Also, cratalic acid and / or physiologically acceptable salts of pentacyclic triterpenes other than the physiologically acceptable salts of the subject of the present invention can also be based on maslinic acid and / or The raw materials and methods described in physiologically acceptable salts are separated from natural materials. The anti-fertilization foods of the present invention can provide anti-hypertrophy and / or anti-overfilling foods However, as mentioned above, the pentacyclic triterpenes of the present invention and physiologically acceptable salts or derivatives thereof have a precursor-type adipocyte proliferation inhibiting function, a precursor-type adipocyte differentiation inhibiting function, or a mature type of fat. cell Fat accumulation inhibition function, according to this function, this paper size is applicable to Chinese National Standard (CNS) A4 specification (210X297 mm) " -64-200300069 A7 B7 V. Description of the invention (β) ι (Please read the precautions on the back before (Fill in this page) and have anti-hypertrophic hypertrophy and / or anti-hypertrophic hypertrophy function. In other words, it is believed that anti-hypertrophy can be obtained mainly by the function of inhibiting the proliferation of precursor adipocytes or inhibiting the differentiation of precursor adipocytes. The function of sexual fullness, so it has the effect of anti-hypertrophic fullness and / or the formation of excessive hypertrophy. Printed by the Ministry of Health Intellectual Property Bureau® Industry and Consumer Cooperatives ¾ The anti-fullness food of the present invention can provide anti-fullness and And / or plump therapeutic tincture. In other words, the present invention contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. It is related to the prevention of plumpness and / or the treatment of plump foods. Use for the purpose of preventing fullness refers to the situation where you start to worry about fullness or when you are concerned about fullness in the long-term or middle-aged period, and use it in advance to prevent fullness. In this case, the loquat food of the present invention is a loquat food containing an anti-hypertrophic substance, such as pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. Therefore, excessive restriction or Reduced dieting is ideal for achieving the goal of healthy plumpness. In addition, the use for the purpose of treating plumpness means being plumped, especially when it is necessary to treat plumpness in terms of health, to improve the condition of plumpness. In this case, the anti-fattiness food of the present invention is a food containing anti-fattiness function such as pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof, so it will require Excessive dieting or changing lifestyle habits can minimize the burden on the body, and can be used to treat fullness through a more moderate diet, etc., which is ideal. In addition, the anti-puffiness foods of the present invention can also be used as foods for weight loss. In other words, the present invention contains one or two selected from the group consisting of pentacyclic triterpenes and their physiologically acceptable salts or their derivatives. The Chinese National Standard (CNS) A4 specification applies to this paper standard ( 210X297 mm) -65-200300069 A7 _B7_ V. The invention description (Seven (please read the precautions on the back before filling out this page) is related to the diet food for weight loss. The purpose of weight loss is to Those who are overweight naturally include those who are not particularly overweight, but need to lose weight when it is necessary to lose weight due to health or beauty. In this case, the food for preventing obesity in the present invention contains five rings Triterpenes and their physiologically tolerable salts or their derivatives have functions such as anti-puffiness, so they do not need to go on an excessive diet with pain or malnutrition, and live in a full diet and It is ideal to effectively lose weight under the nutritional supply. Printed by the Consumer Cooperative of the 1st Bureau of Wisdom and Finance of the Ministry of Economic Affairs ¾ Furthermore, the anti-obesity foods of the present invention can also be used to improve the foods that are not easily full In other words, the present invention is used for improving one's physical fitness by selecting one or two or more types from a group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof.飮 Food related. The so-called use for the purpose of improving the body is not easy to plump, refers to the fundamental and long-term plump countermeasures to improve the physique of the body itself and cause the body to become plump. In this case, the present invention Anti-plump foods are foods containing pentacyclic triterpenes and physiologically acceptable salts or derivatives that have anti-plumping properties, so they do not accompany long-term dieting. And other pains, and it is ideal to improve the physical fitness without getting enough nutrition and food. In a specific embodiment of the present invention, for example, the defatted residue obtained by the olive oil manufacturing process can be extracted with ethanol solution to obtain The dried and concentrated concentrate is an example of edible oils and fats containing 0.1 to 5% by mass of the above-obtained concentrate as maslinic acid obtained by GC analysis. Also, another aspect of the present invention is: Specific implementation forms, for example, can use the Chinese olive ^ paper size to apply Chinese National Standards (CNS) A4 specifications (210X297 mm) " -66-200300069 A7 B7 V. Description of the invention (6 ^ degreasing or residue obtained from the oil manufacturing process to For ethanol solution extraction, take 1 ~ 30% by mass of the lettuce seasoning containing the extract obtained above as an example. (Please read the precautions on the back before filling this page) Another embodiment of the present invention Form, for example, the degreased residue obtained by the manufacturing process of olive oil can be extracted with ethanol solution, and the obtained extract can be dried to be concentrated into a concentrate. The content of the concentrate containing maslinic acid fraction by GC analysis is 0.1 to 5% by mass. Lettuce for lettuce is taken as an example. In another specific embodiment of the present invention, for example, the residue of the pressed oil obtained by the olive oil manufacturing process can be extracted with an ethanol solution, and the obtained extract can be dried to be concentrated into a concentrate. An example of the material containing the concentrate is 0.1 to 5% by mass. In another specific embodiment of the present invention, for example, the degreased residue obtained by the manufacturing process of foreign olive oil can be subjected to extraction treatment with an ethanol solution, and the obtained extract can be dried and concentrated to calculate the content of maslinic acid obtained by GC analysis of the concentrate. As an example, a tablet containing 0.5 to 25% by mass can be used as an example. Printed by the Consumers ’Cooperative of the 1st Bureau of the Ministry of Economic Affairs, another specific embodiment of the present invention. For example, the residue of the pressed oil obtained by the manufacturing process of foreign olive oil can be extracted with ethanol solution, and the resulting extract can be dried and concentrated. For example, a cracker containing 0.1 to 5% by mass of maslinic acid, which is obtained by GC analysis of the concentrate, may be used as an example. In another specific embodiment of the present invention, for example, the degreased residue obtained by the manufacturing process of foreign olive oil can be subjected to extraction treatment with an ethanol solution, and the obtained extract can be dried and concentrated to calculate the content of maslinic acid obtained by GC analysis of the concentrate. For example, a clothing liquid containing 0.5 to 5% by mass and a frying conditioner (frozen food) are exemplified. In addition, in another specific embodiment of the present invention, for example, the Chinese National Standard (CNS) A4 specification (210X297 mm) can be applied based on the size of the foreign paper I " -67-200300069 A7 _ _ B7_ __ V. Description of the invention (Take (please read the precautions on the reverse side and fill in this page) Extraction residues from olive oil manufacturing process are extracted with ethanol solution, and the resulting extracts are dried and concentrated to include the maslinic acid obtained by GC analysis of the concentrate. 0.05 to 2.5% by mass of sauce can be exemplified. In addition, another specific embodiment of the present invention, for example, the degreased residue obtained by the manufacturing process of foreign olive oil can be extracted with an ethanol solution, and the obtained extract can be concentrated by drying and The content of maslinic acid obtained by GC analysis containing the concentrate can be exemplified by containing 0.1 to 5% by mass of beauty milk. In addition, in another specific embodiment of the present invention, for example, the pressed oil residue obtained by the manufacturing process of foreign olive oil can be used to Extraction treatment with ethanol solution. The obtained extract is dried and concentrated. Based on the maslinic acid containing the concentrate obtained by GC analysis, it contains 0.1 to 5% by mass of margarine. For example, printed by the Consumer Cooperatives of the 1st Bureau of Wisdom and Finance of the Ministry of Economic Affairs, the present invention contains one or two or more selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. These are related to anti-hypertrophy foods. These pentacyclic triterpenes have a particularly excellent anti-fertilizer function of precursor-type adipocyte proliferation inhibition function, precursor-type adipocyte differentiation inhibition function, and mature adipocyte fat accumulation inhibition function. Full-featured. The fermented foods for anti-fullness of the present invention do not require a special burden in terms of time or labor, and it is ideal to simply and continue to enjoy the anti-fullness function. Moreover, the pentacyclic triterpenes of the present invention may be It is obtained from natural plants and can be used safely in daily use, especially when it is derived from olives. It is ideal for users to give a feeling of spiritual comfort. Examples Examples of the present invention are shown below, but The present invention is not limited by these ^ The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) " -68- 200300069 A7 _B7_ V. Description of the invention (4). The following mass percentages are expressed in% of units. (Please read the precautions on the back before filling this page.) Pentacyclic triterpene cocadiols (manufactured by Funakoshi), ursolic acid (and (Manufactured by Kwangjon Pharmaceutical Co., Ltd.), arbutanol (manufactured by Funakoshi Corporation), betulinic acid (manufactured by Funakoshi Corporation), betulin (manufactured by Funakoshi) After heating to boiling point and dissolving in ethanol to saturation, it is cooled, recrystallized, filtered, dried, and reused. Hawthorn acid is described in the following examples, which are extracted from the olive plant, purified, and confirmed to have a purity of 95%. < Manufacturing example 1 > 500g of dried fruits (including seeds) of domestic olives (Olea europaea L.) produced in Japan were crushed, and 3 was added < Hexane extraction for 3 hours. The seeds were removed from the defatted fruits after repeated four times, the seeds were pulverized, and then extracted with 5 times the amount of hexane for 3 hours to obtain 229 g of defatted matter (defatted meal) from which oil was completely removed. A 10-fold amount of an aqueous ethanol solution having an ethanol content of 60% by mass was added to the degreased material, and the mixture was extracted with vigorous stirring at room temperature for 3 hours. After filtering the entire amount, the filtrate was concentrated to dryness to obtain 112.7 g of extract. Printed by the Xiaohuang Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Add 100 g of this extract to 2 < Water, vigorously stirred at room temperature for 1 hour. After the entire amount was centrifuged, the supernatant was removed by decantation and the resulting precipitate was dried to obtain 10.0 g of a concentrate. Next, the concentrate was fractionated by silica gel column chromatography with a column filled with about 40 times (400 g) of silica gel. First, 10 times the amount of gel (4000ml) of hexane: ethyl acetate = 3: 1 eluate to remove excess components, and then 2.5 times (100ml) of hexane: ethyl acetate = 1: 1 dissolving solution dissolves excess and does not need cost. Paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) " -69-200300069 A7 B7 V. Description of the invention (4 copies. 10 times the amount (4000ml) of hexane: ethyl acetate = 1: 1 eluent to dissolve the target maslinic acid to obtain the crude maslinic acid fraction. From this fraction (please read the precautions on the back before filling this page) Remove After hexane and ethyl acetate, vacuum drying to obtain 1.96 g of crude maslinic acid fraction. The crude column was filled with about 30 times the amount (60 g) of octadecyl silicone gel, and the crude product was purified by ODS column chromatography. Fraction of maslinic acid. First, the silica gel filled with 10 times the amount (600ml) is filled with methanol: water = 8: 2 eluent to dissolve the impurities which are not needed. Then, the methanol filled with the silica gel with 30 times the amount (1 800ml) is filled with: Water = 8: 2 dissolves the maslinic acid from the target to obtain the refined maslinic acid fraction. After removing methanol from this fraction, It was dried to obtain 1.51 g of refined maslinic acid 1. Here, analysis by NMR, MS and the like confirmed that this refined maslinic acid 1 was in a state of a part of sodium salt and potassium salt, and the rest was mostly in a state of free acid. The purity was measured by GC, and it was confirmed that the purity of maslinic acid was 95% or more. < Manufacturing Example 2 > 10 kg of 65% by mass of ethanol was added to oil residue (pressed oil meal) to the oil residue (pressed oil meal) of the Intellectual Property Office of the Intellectual Property Bureau of the Ministry of Economic Affairs of the Ministry of Economic Affairs of the Ministry of Economic Affairs of the Ministry of Economic Affairs of the Ministry of Economic Affairs of the Ministry of Economic Affairs of the Ministry of Economic Affairs. The aqueous ethanol solution was extracted with vigorous stirring at room temperature for 3 hours. After filtering the whole amount, the solid filtrate was concentrated to obtain 20.2 g of an extract. Add 1 ί n-butanol, 1 to this extract < Water, stirred for 10 minutes, and then separated into an n-butanol phase and an aqueous phase. After the n-butanol phase of the n-butanol phase was removed, it was vacuum dried to obtain 1.33 g of a concentrate. Secondly, the silica gel column filled with about 40 times the quantity (500g) of silica gel. The paper size is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) '-70- 200300069 A7 _B7 V. Description of the invention (蛉(Please read the precautions on the back before filling this page) Chromatographically fractionate this concentrate. First, use 10 times the amount of gel (50 00 ml) of hexane: ethyl acetate = 3: 1 eluate to remove excess After the ingredients, 2.5 times (1250 ml) hexane: ethyl acetate = 1: 1 eluent is used to dissolve excess unnecessary components. Then fill 10 times (5000ml) of hexane: ethyl acetate with silica gel. Ester = 1: 1 eluate dissolves the target maslinic acid to obtain the crude maslinic acid fraction. After removing hexane and ethyl acetate from this fraction, it is dried under vacuum to obtain 2.66 g of crude maslinic acid fraction. The column of octadecylsilicone with 30 times the amount (80g) was purified by ODS column chromatography. Firstly, 10 times the amount (800 ml) of silica gel filled with methanol: water = 8 : 2 dissolving liquid to dissolve out impurities without the need of ingredients. Then 30 times the amount (2400 ml) of silica gel filled with methanol: water = 8: 2 dissolving liquid dissolving The purified maslinic acid fraction is obtained from the maslinic acid which is obtained. After removing the methanol from this fraction, vacuum drying is performed to obtain 2.06 g of refined maslinic acid 2. Here, it is confirmed by NMR, MS analysis that the refined maslinic acid 2 is a part of it Part of the free acid state, most of the rest are in the state of sodium or potassium salt. Also, the purity was measured by GC to confirm that the purity of maslinic acid is above 95%. System < Manufacturing Example 3 > In a 1 kg olive oil production step obtained from the extraction residue of Italian olives (re-processed the degreased oil residues in the extraction step), 10 times the amount of ethanol was added, and the mixture was heated to 55 ° C and vigorously stirred while extraction. 3 hours. After filtering the entire amount, the filtrate was concentrated and dried to obtain 35 g of an extract. This concentrate was then fractionated by silica gel column chromatography filled with about 40 times (1400 g) silica gel column. First 10 times the amount of gel (14 <) Hexane: This paper size is in accordance with Chinese National Standard (CNS) A4 (210X297 mm) -71-200300069 A7 B7 V. Description of the invention (4 Ethyl acetate = 3: 1 The dissolving liquid leaves the excess After the ingredients, 2.5 times the amount (3500ml) of hexane: ethyl acetate = 1: 1 eluent to dissolve excess unnecessary components. Then fill 10 times the amount of silica gel (14 hexane: ethyl acetate = The 1: 1 dissolution solution dissolves the target maslinic acid to obtain a crude maslinic acid fraction. After removing hexane and ethyl acetate from this fraction, vacuum drying is performed to obtain 5.90 g of a crude maslinic acid fraction. It is filled with about 30 times more A quantity (180g) of octadecyl silica gel column, and the crude maslinic acid fraction was purified by ODS column chromatography. First, the silica gel was filled with 10 times (1 800ml) methanol: water = 8: 2 to dissolve The liquid dissolves out impurities without the need of ingredients. Then, 30 times the amount (5 400 ml) of silica gel filled with methanol: water = 8: 2 dissolves the target maslinic acid to dissolve the purified maslinic acid fraction. From this distillation After the methanol was removed, 5.36 g of refined maslinic acid 3 was obtained by vacuum drying. Here, NMR, MS and other analysis confirmed that this refined maslinic acid 3 was one of the first. Parts are in the state of sodium salt and potassium salt, and the rest are mostly in the state of free acid. In addition, the purity of these was measured by GC to confirm that the purity of maslinic acid was 97% or more. As pentacyclic triterpenes The olefin derivatives are obtained as follows. < Synthesis example > A solution obtained by dissolving 4.5 g of maslinic acid and 1.0 g of triethylamine in 50 ml of chloroform and dissolving 1.1 g of sulfenyl chloride in 10 ml of chloroform was dropped, and stirred for 1 hour. Subsequently, 3.2 g of ethanol was added, and 1.0 g of diethylamine was dissolved in 10 m of chloroform under ice-cooling, followed by stirring for 3 hours. After completion of the reaction, the chloroform dissolved component was extracted, and the crude reaction product obtained by distilling off chloroform was purified by silica gel column chromatography to obtain 3.5 g of ethyl maslinate. This paper scale is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm)-Packing-(Please read the precautions on the back before filling this page) Order printed by the Ministry of Economic Affairs and the Intellectual Property Cooperative 4th Bureau-72- 200300069 A7 B7 V. Description of the invention (6¾ < Synthesis Example 2 > 2,3-0-diethylfluorenyl-maslinic acid (please read the precautions on the back before filling this page). Dissolve 2.0 g of maslinic acid in 100 ml of pyridine and add 50 ml of acetic anhydride and stir overnight. After distilling off the pyridine and vinegar, the residue was dissolved in ether, washed once with a 1N aqueous hydrochloric acid solution, once with a saturated sodium bicarbonate solution, and washed with pure water three times, and then added magnesium sulfate and left overnight. The magnesium sulfate was removed by filtration, and the crude reaction product obtained by distilling off the ether was purified by silica gel column chromatography to obtain 2.2 g of 2,3-0-diethylfluorenyl-maslinic acid. < Synthesis Example 3 > 2,3-0-triethylsilyl-massyl triethylsilyl ester 1.0 g of maslinic acid was dissolved in 200 ml of anhydrous dimethylformamide, and 144.0 mg of imidazole and 04.0 C were added at 0 ° C. 350 μ1 triethylsilyl chloride, sealed and stirred for 2 hours. After distilling off dimethylformamide, the residue was dissolved in ether, and the ether phase was washed once with 1N aqueous hydrochloric acid solution, once with saturated sodium bicarbonate solution, and three times with pure water, and then magnesium sulfate was added to stand overnight. The magnesium sulfate was removed by filtration, and the crude reaction product obtained by distilling off the ether was purified by silica gel column chromatography to obtain 1.5 g of 2,3-0-triethylsilyl · massate triethylsilyl ester. Qi Qilang Printed by Employee Consumer Cooperatives < Synthesis Example 4 > 2,3-0-Distearyl-ethyl maslinate was dissolved in 50 ml of anhydrous toluene with 1.0 g of ethyl maslinate obtained in Synthesis Example 1, and 5.0 g of triethylamine was added thereto. Under ice cooling, 6.0 g of chlorine stearate was slowly added and stirred for 1 hour. Slowly return to room temperature and stir for 9 hours. Add an appropriate amount of 1N hydrochloric acid aqueous solution, extract with ether, once with saturated sodium bicarbonate solution, wash the ether phase with pure water three times, and then add magnesium sulfate and leave it overnight. This paper size is applicable to the Chinese National Standard (CNS) A4 (210X297 mm) '-73-200300069 A7 B7 V. Description of the invention (7b Magnesium sulfate is removed by filtration and purified by silica gel column chromatography. The crude reaction product yielded 1.2g of 2,3-0-di-stearylyl-maslinate. (Please read the precautions on the back before filling in this page} < Synthesis example 5 > 3,28-0-diethylfluorenyl-cocadiol 5.0 g of cocadiol was dissolved in 250 ml of pyridine, and 100 ml of acetic anhydride was added and stirred overnight. After distilling off the pyridine and acetic anhydride, the residue was dissolved in ether, washed once with a 1 N aqueous hydrochloric acid solution, once with a saturated sodium bicarbonate solution, and three times with pure water, and then added magnesium sulfate and left overnight. The magnesium sulfate was removed by filtration, and the crude reaction product obtained by distilling off the ether was purified by silica gel column chromatography to obtain 5.4 g of 3,28-0-diethylfluorenyl-cocadiol. < Synthesis Example 6 > Printed by the Consumer Cooperatives of the Wisdom Finance Bureau of the Ministry of Economic Affairs, Ethyl Ursolic Acid, 5.0 g of ursolic acid 1.lg triethylamine was dissolved in 50 ml of chloroform, and 1.2 mg of sulfinyl chloride was dissolved in ice-cold solution. 10 ml of the obtained chloroform was dropped and stirred for 1 hour. Subsequently, 3.5 g of ethanol was added, and 1.1 g of triethylamine was dissolved in 10 ml of chloroform under ice-cooling, followed by stirring for 3 hours. After the reaction was completed, the chloroform dissolved component was extracted, and the crude reaction product obtained by distilling off chloroform was purified by silica gel column chromatography to obtain 3.8 g of ethyl ursolic acid. < Synthesis Example 7 > 3,28-0-diethylfluorenyl-arsanol 5.0 g of arsitol was dissolved in 250 ml of pyridine, and 100 ml of acetic anhydride was added and stirred overnight. After distilling off the pyridine and acetic anhydride, the residue was dissolved in ether, and the ether phase was washed once with 1N aqueous hydrochloric acid solution, once with saturated sodium bicarbonate solution, and three times with pure water, and then magnesium sulfate was added to stand overnight. Filtered to remove the standard applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) " '' -74-200300069 A7 B7 V. Description of the invention (7) l Magnesium sulfate, purified by silica gel column chromatography and distilled away The crude reaction product obtained from diethyl ether gave 5.4 g of 3,28-0-diethylamidoarsanol. < Synthesis example 8 > Ethyl betulinate 5.0 g of betulinic acid 1.1 g of triethylamine was dissolved in 50 ml of chloroform and ice-cooled. The solution obtained by dissolving 1.2 mg of sulfenyl chloride in 10 ml of chloroform was dropped and stirred for 1 hour. Next, 3.15 g of ethanol was added, and 1.1 g of triethylamine was dissolved in 10 ml of chloroform under ice-cooling, and the mixture was stirred for 3 hours while being dropped. After the reaction, the chloroform dissolved component was extracted, and the crude reaction product obtained by distilling off chloroform was purified by silica gel column chromatography to obtain 3.8 g of ethyl betulinate. < Synthesis Example 9 > 3,28-0-diethylfluorenyl-birulinol 5.0 g of betulin was dissolved in 250 ml of pyridine, and 100 ml of acetic anhydride was added and stirred overnight. After distilling off the pyridine and acetic anhydride, the residue was dissolved in ether, and the ether phase was washed once with 1N aqueous hydrochloric acid solution, once with saturated sodium bicarbonate solution, and three times with pure water, and then magnesium sulfate was added to stand overnight. The magnesium sulfate was removed by filtration, and the crude reaction product obtained by distilling off the ether was purified by silica gel column chromatography to obtain 5.4 g of 3,28-0-diethylfluorenyl-betulin. Test Example 1 [Evaluation of Proliferation-Inhibiting Function of Precursor Adipocytes] A mouse precursor-producing adipocyte cell line 3T3-LI (ATCC deposit, deposit number CL-173) was used in a tissue culture bottle at a density of 3xl05 cells / 75cm2. (Product made by Nunc), the paper size containing 10% bovine fetal blood pupa is applicable to the Chinese National Standard (CNS) A4 (210X297 mm) (Please read the precautions on the back before filling this page)-Packing · Printed by the Intellectual Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs-75- 200300069 A7 B7 V. Description of the invention (7 ^ DMEM medium (manufactured by Nakaraitesq)). After entering the second half of the logarithmic growth period, the cells were treated with lx104. Cells were transplanted at a density of 0.32 cm2 into a multi-well culture plate (product of Corning Costar), and cultured for 48 hours in a DMEM medium containing 1% bovine fetal blood pupa with various triterpenes added at the concentrations described in Table 1. At the 44th hour after the start, Alamar BlueTM (manufactured by Alamar) will be added and cultured for another 4 hours. After the end of the culture, the fluorescent substance produced by the oxidation-reversion reaction of the cells will be fluoresced. Measured with a photometer, and compared with the fluorescence intensity of the control group to calculate the cell proliferation inhibition rate. (Evaluation criteria) Only the test group in which a triterpene solvent was dissolved was used as the control group, and the fluorescence intensity obtained by the control group was Calculate the proliferation inhibition rate with the fluorescence intensity when the test substance is added at 100%. The calculation formula is as follows: 1 ° Equation 1 Proliferation inhibition rate (%) = 100-(Fluorescence intensity when the test substance is added / When the control group is added Fluorescence intensity) X 100 (Please read the precautions on the back before filling out this page)-Equipment _ Ordered by the Bone Cooperative Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs The previous evaluation was based on the evaluation method, and the increase in the yield was based on the results. The paper size of the surface is applicable to the Chinese National Standard (CNS) A4 specification (210X297 mm) -76 · 200300069 A7 B7. 5. Description of the invention (凫 J table < Proliferation-inhibiting rate of precursor type adipocytes (%) > Concentration (yg / m 1) 6 12.5 25 50 100 Standard conjugated linoleum 0 20 30 40 40 Purified maslinic acid of the present invention 1 10 35 94 95 95 Refined Cratalic acid 2 10 30 90 95 95 Refined Cratalic acid 3 11 36 94 95 95 Cocadiol 11 80 95 95 95 Ursolic acid 18 83 94 95 95 Ursanol • • 30 38 76 Birch acid abuse • 30 69 92 Birch Alcohol • See 28 76 94 Compound of Synthesis Example 1 40 40 84 86 90 Compound of Synthesis Example 15 30 83 89 95 95 Compound of Synthesis Example 3 33 33 79 84 91 Compound of Synthesis Example 12 30 77 94 94 Synthesis of 5 Compound 20 78 95 96 96 Compound of Synthesis Example 6 80 80 93 95 95 Compound of Synthesis Example 7 • Scale 30 70 80 Compound of Synthesis Example 8 • 30 73 95 Compound of Synthesis Example 9--35 71 95 (Please read the back first Please note this page and fill in this page again.) Qi Qilang Zhishigou employee consumer cooperative printed from Table 1 shows that maslinic acid, cocadiol, ursolic acid, ursolic alcohol, betulinic acid, betulin and its physiologically acceptable Permissible salts or their derivatives, etc. Use Chinese National Standard (CNS) A4 specification (210X297 mm) -77-200300069 A7 B7 V. Description of the invention (7i drive type fat cell proliferation inhibiting function compared with conjugated linoleum known to have a strong anti-hypertrophic function substance Acid is more powerful. (Please read the notes on the back before filling out this page) According to this, maslinic acid, cocadiol, ursolic acid, ursitol, betulinic acid, betulin and its physiologically acceptable salts Or their derivatives will have an outstanding contribution to the proliferative inhibition function of precursor adipocytes. Test Example 2 < Evaluation of the function of inhibiting the differentiation of precursor adipocytes and the function of inhibiting fat accumulation in mature adipocytes > Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, will be derived from the rat precursor adipocyte cell line 3T3- LI (ATCC deposit, deposit CL-173) was cultured in a tissue culture flask (manufactured by Nunc) at a density of 3 x 105 cells / 75 cm2 in DMEM medium (manufactured by Nakaraitesq) containing 10% bovine fetal blood pupa. Then, the differentiation-inhibitory function was evaluated by the following method. After entering the logarithmic growth phase two days later, the cells were transplanted into a 1.9 cm2 multi-well culture plate (coming Costar) at a density of 8 x 103 cells / well, and cultured for 4 to 7 days according to the concentrations described in Table 2 DMEM medium and triterpenes containing differentiation factors were added and cultured for another 48 hours. Then, it was cultured in DMEM medium containing bovine fetal blood pupa and insulin for another 8 days. After the end of the culture, a lysis buffer was added to each culture well, and the amount of fat in the lysate was measured by a triglyceride G-wako tester (manufactured by Wako Pure Chemical Industries, Ltd.) to estimate the amount of fat taken up by the adipocytes. The amount of triglyceride was compared with the control group to calculate its adipocyte differentiation inhibitory function. In addition, the fat accumulation inhibiting function was cultured for 2 days under the coexistence of differentiation factors, and the paper was changed to contain bovine fetal blood. The paper size was adapted to the Chinese National Standard (CNS) A4 (210X297 mm) -78-200300069 A7 B7 V. Invention Note (When adding 7 胰岛素 and insulin in DMEM medium, add each triterpene at the concentration described in Table 2 and incubate for another 8 days. After the end of the culture, follow the same procedure to evaluate the differentiation inhibition function. The function of inhibiting fat accumulation in adipocytes is calculated. (Evaluation criteria) When a solvent group that dissolves only triterpenes is added as a control, when the amount of triglyceride obtained from the control is 100%, the triglyceride when the test substance is added Calculate the differentiation and fat accumulation inhibition rate based on the amount. The calculation formula is shown in the following formula 2. Formula 2 Inhibition rate of differentiation and fat accumulation (%) = 100- (the amount of triglyceride when the test substance is added / the triglyceride of the control group Ester amount) X 100 The proliferative fat cell proliferation inhibition function and mature adipocyte fat accumulation inhibition function were evaluated according to the above method. The production rate is shown in Table 2. (Please read the precautions on the back before filling out this page) "Binding and ordering printed on paper standards of the Ministry of Economic Affairs Intellectual Property Bureau staff poverty alleviation cooperatives The paper standards are applicable to China National Standard (CNS) A4 specifications ( 210X297 mm) -79 · 200300069 A7 B7 printed by the Consumers' Cooperative of the 1st Bureau of Wisdom and Finance of the Ministry of Economic Affairs < Precursor type adipocyte differentiation and inhibition rate of fat accumulation (%) > Concentration (ug / ml) Inhibition rate of differentiation (%) Inhibition rate of fat accumulation (%) Inhibition rate of differentiation (%) SI Inhibition rate of fat accumulation (%) SI Standard Conjugated Linoleum 5 11.0 21.0 Refined maslinic acid of this invention 1 5 82.0 83.5 7.5 4.0 Refined maslinic acid 2 5 80.0 81.7 7.3 3.9 Refined maslinic acid 3 5 82.5 84.0 7.5 4.0 Cocadiol 5 78.5 80.4 7.1 3.8 Bear Fruit acid 5 65.4 66.9 5.9 3.2 Ursolic alcohol 5 55.4 59.2 5.0 2.8 Betulinic acid 5 60.0 63.8 5.5 3.0 Betulin 5 72.3 70.2 6.6 3.3 Compound of Synthesis Example 5 84.3 83.9 7.7 4.0 Compound of Synthesis Example 5 82.8 80.1 7.5 3.8 Synthesis Compound 5 in Example 3 81.0 78.0 7.4 3.7 Compound 5 in Synthesis Example 4 83.6 82.6 7.6 3.9 Compound 5 in Synthesis Example 5 75.0 78.0 6.8 3.7 Compound 5 in Synthesis Example 6 69.5 80.0 6.3 3.8 Compound 5 in Synthesis Example 7 60.4 63.2 5.5 3.0 Synthesis Compound 5 of Example 8 65.1 66.6 5.9 3.2 Synthesis of Compound 5 of Example 9 75.5 74.1 6.9 3.5 Table 2 shows that maslinic acid, cocadiol, ursolic acid, ursitol, 'Package-(Please read the notes on the back before filling this page) The size of the bound paper is applicable to the Chinese National Standard (CNS) A4 (210X297 mm) -80-200300069 A7 B7 V. Description of the invention (7 > (Please Read the precautions on the back before filling in this page.) Compared with the pre-cursor type adipocyte differentiation inhibition function and mature adipocyte fat accumulation inhibition function, lignan, betulin and physiologically acceptable salts or derivatives thereof It is known that conjugated linoleic acid with a strong anti-pigmenting function is more powerful. According to this, maslinic acid, cocadiol, ursolic acid, ursitol, betulinic acid, betulin and its physiologically acceptable salts Or their derivatives, etc., will contribute significantly to the function of inhibiting precursor adipocyte differentiation and / or inhibiting fat accumulation in mature adipocytes. Test Example 3 < Body Fat Accumulation Inhibition Test> Printed by the Consumer Cooperatives of the Smart Finance Bureau of the Ministry of Economic Affairs The body fat accumulation inhibition test was performed as follows. Wister males (6 weeks old, average weight 160g) were pre-breeded with AIN-93 powder for one week, and then divided into 12 groups (8 animals per group) according to the average body weight. The feed added with the test substance described in Table 4 (soybean oil for the control group) was allowed to be freely ingested for 8 weeks. In addition, the above-mentioned feed is based on the ingredients described in Table 3, and corn starch reduced by the same quality is used for the extra components when the test substance is added. After 8 weeks, the test mice of each group were dissected, and the subcutaneous and visceral fat mass was measured, and the fat accumulation rate for the total weight was calculated. This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) -81- 200300069 A7 B7 V. Description of invention (7¾ Table 3 < Feed composition> Composition composition (%) Corn starch 52.95 Casein 20.0 Sucrose 10.0 Refined soybean oil 7.00 Cellulose 5.00 Mixed minerals (AIN- 93G) 3.50 Mixed vitamins (AIN- 93G) 1.00 L · Cysteine 0.30 weight Biletan tartrate 0.25 (Please read the precautions on the back before filling out this page) 钍 Printed by Suji Consumers ’Co-operation and Consumption Coordination (Evaluation Criteria) Soybean intake group as the control group, the body fat accumulation rate obtained by the control group When it is 100%, the body fat accumulation rate from the test substance ingestion group is calculated according to the following formula 3 to calculate the body fat accumulation inhibition rate. Formula 3 Inhibition rate of body fat accumulation (%) = 100- (Body fat accumulation rate of test substance intake group / Body fat accumulation rate of control intake group) x 100 The body fat accumulation inhibition function is evaluated according to the above method, and the result is body fat The accumulation suppression rate is shown in Table 4. This paper size is applicable to Chinese National Standard (CNS) A4 (210X29 * 7mm) -82 · 200300069 Α7 Β7 V. Description of the invention (7¾ 苐 4 <: body fat animal administration amount (g / feed 100g) body fat accumulation inhibition rate (%) Group 1 soybean oil (control) •-Extract from Group 2 Manufacturing Example 2 10.0 9.3 3 Concentrate obtained from group production example 5.0 10.2 Group 4 refined mangoic acid 1 1.0 12.5 Group 5 refined mangoic acid 2 1.0 13.6 Group 6 cocadiol 1.0 20.9 Group 7 ursolic acid 1.0 19.1 Group 8 ursula Alcohol 1.0 10.3 Group 9 betulinic acid 1.0 9.5 Group 10 betulin 1.0 1.0 Group 11 Compound 1 Synthesis Example 1.0 1.0 15.0 Group 12 Synthesis Example 2 Compound 1.0 18.2 Group 13 Refined Mangolic Acid 3 1.0 12.4 (Please read first Note on the back, please fill out this page again.) 瞍 Qilang Wisdom Hours 消费 Printed by Employee Consumer Cooperatives. Table 4 shows that various pentacyclic triads and their physiologically tolerable § noon salts or their derivatives can be used. The group is intentional than the control group (ie P <0.05; Inhibition of body fat accumulation. In addition, oral intake of natural extracts (maslinic acid content of 12.2%) and its concentrates (maslinic acid content of 19.5%) can also show the function of inhibiting body fat accumulation. Accordingly, it has been shown that various pentacyclic triterpenes and their physiologically acceptable salts or their derivatives will have an excellent contribution to the anti-puffiness function. In addition, when obtained from nature, it is concentrated and / or separated / refined compared to extracting only Chu. The paper size of pure paper is applicable to China National Standard (CNS) A4 (210 × 297 mm) -83-200300069 A7 B7 _ 5 、 Instructions of invention (there is a tendency to display higher functions. (Please read the precautions on the back before filling this page) Test Example 4 < Safety confirmation test for animals > An acute toxicity test was performed according to the following method. Wister female rats (6 weeks old, average weight: 160g) were pre-bred with powdered feed consisting of AIN-93 for one week, and then divided into 6 groups (eight in each group) based on the average body weight becoming equal. The maslinic acid administration group, the cocadiol administration group, the ursolic acid administration group, the ursolic alcohol administration group, the betulinic acid administration group, and the betulin alcohol administration group respectively suspended the test substances in cottonseed. In the oil, 2,000 mg / kg of body weight was forcibly administered orally by a probe. Continue to use AIN-93 powder to prepare feed, observe the feeding status 2 weeks after administration, and then dissect and examine the internal organs status 2 weeks later. As a result, there were no deaths in all groups 2 weeks after administration, and no abnormalities were found in the visceral examination of the anatomy. From this, it can be known that LD5G of various pentacyclic triterpenes is more than 2000 mg / kg body weight, is extremely safe and excellent, and can be ingested orally in the form of food. Printed by the Consumer Finance Cooperative of the 4th Bureau of Smart Finance, Ministry of Economic Affairs, Test Example 5 < Body fat accumulation inhibition test > SD male rats (6 weeks old, average weight: 160g) were pre-breeded in solid form (researched MR storage feed, manufactured by Nippon Kogyo Co., Ltd.) for one week, and then The average weight becomes equal and is divided into 5 groups (4 in each group), so that they can freely ingest the powder composed of AIN-93 added with the test substance. The paper size applies the Chinese National Standard (CNS) A4 specification (210X297 mm)- 84-200300069 V. Description of the invention (Power feed for 4 weeks. The composition of the above feed is shown in Table 5. In addition, all groups are added with 7% by mass of blended oil (soybean oil: rapeseed oil = 3: 7) ° After 4 weeks, the test group was dissected for 6 hours after fasting, and the total visceral fat (peripheral entrapment, mesenteric and perirenal) and subcutaneous fat were measured. From this measurement, the weight of the final body weight was measured. Calculate the fat accumulation rate of the fat mass of each part. Use the total of visceral fat (peripheral parasomnia, mesenteric and renal) and subcutaneous fat mass as the body fat mass, and then calculate the body fat accumulation rate for the final weight. Then ingest The fat accumulation rate when the oil distribution group is the control group is compared with the fat accumulation rate of the test substance, and the fat accumulation inhibition rate is calculated according to the following formula 4 to confirm the fat accumulation inhibition effect. The results are shown in Table 6. (Please read the notes on the back before filling out this page.) Form 5 printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs < Feed composition > Composition composition (%) Blend oil group 96-0.1% group 96-0.01% group 18-0.5 group 18-0.05 group corn starch 52.9 52.8 52.9 52.4 52.9 casein 20.0 20.0 20.0 20.0 20.0 sucrose 10.0 10.0 10.0 10.0 10.0 Blended oil 7.0 7.0 7.0 7.0 7.0 Cellulose 5.0 5.0 5.0 5.0 5.0 Mixed minerals (AIN-93G) 3.5 3.5 3.5 3.5 3.5 Mixed vitamins (AIN-93G) 1.0 1.0 1.0 1.0 1.0 Cysteine 0.3 0.3 0.3 0.3 0.3 Bile Tartrate 0.3 0.3 0.3 0.3 0.3 Tested Substance 0.0 0.1 0.01 0.5 0.05 This paper size is applicable to Chinese National Standard (CNS) A4 specification (210 × 297 mm) -85- 200300069 A7 B7 V. Description of the invention (4 < Inhibition rate of fat accumulation > Formula 4 Inhibition rate of fat accumulation in each part and body (%) = 100- (fat accumulation rate of the test substance intake group / fat accumulation rate of the control intake group) x 100 (please read the back Note: Please fill in this page again.) Printed by the Employees' Cooperatives of the Intellectual Property Bureau of the Ministry of Economy. The paper size is applicable to Chinese National Standard (CNS) A4 (210X297 mm) -86- 200300069 A7 B7. Inhibition rate of body fat printed by employees' cooperative of property bureau (%) 1 CO ON% < »—η 1 * accumulation rate (%) 13.34 13.17 12.55 12.71 11.86 i] cn inhibition rate (%) a cn Ό r 'i Ο 1— ^ y- accumulation rate (%) 7.36 7.34 7.17 6.99 6.62 total visceral inhibition Rate (%) 1 〇〇οα 5 CN 04 oi accumulation rate (%) 5.97 5.80 5.39 g 8 maslinic acid 1 0.09 0.009 0.09 0.009 W 蛔 ta, test substance 1 wn 0.05 5 .ο ο dosing substance preparation oil (control ) Concentrate obtained in Production Example 2 Concentrate obtained in Production Example 2 Purified maslinic acid 1 Purified maslinic acid 1 Group 1 Group 2 Group 3 Group 4 Group 5 (Please read the precautions on the back before filling out this page) C .

， 1T. The size of this paper applies Chinese National Standard (CNS) A4 (210X297mm) -87-200300069 A7 B7 V. Description of invention (please read the precautions on the back before filling this page) Form 6 It can be seen that the intake of added maslinic acid feed groups can confirm the effect of reducing body fat compared with the control group. The trend is obvious in the low-dose feed intake group compared with the high-dose feed intake group, and it can be seen that a small amount can have excellent anti-fertility Full function. In addition, a small amount of effective results can be seen from the daily intake. The above shows that in order to obtain the anti-puffiness effect of the present invention, it is unnecessary to ingest high concentrations and large amounts. On the contrary, it is within a certain range of low content range. Can also play an excellent anti- plump effect. Also, it is found that the blended European olive extract can also play an anti- plump function, but it is also known that after concentrating, refining, pure people can obtain more excellent effects. In addition, Olive extract and its concentrated, refined (purified) to obtain maslinic acid. Compared with the anti-puffiness function, concentrated and refined (purified) to obtain maslinic acid can make visceral fat and subcutaneous fat. Homogeneous reduction. When only paying attention to the subcutaneous fat, it can be concentrated and refined (purely separated) to obtain maslinic acid which can reduce the subcutaneous fat. EXV, 1000.Og of olive oil At the above blending ratio, add refined maslinic acid 1 to EX V (Extravigin) olive oil, and keep it mixed with a blender at 60 ° C until the whole is smooth and dissolve to produce food. Grease. The paper scale is applicable to Chinese National Standard (CNS) A4 (210X29 * 7mm) '----88-200300069 A7 B7 V. Description of the invention (8 & Example 2 Seasoning for lettuce salad (please read first Note on the back side, please fill in this page again.) 30.0g of the extract obtained in Manufacturing Example 1 46.6g water Xanthan gum O.lg fructose glucose glucose 5.0g table salt 5. Og MSG 0.3g rice vinegar (acidity 10%) 10.〇g Pepper Soybean Salad Oil 3 0.0 g Printed by the Consumers ’Cooperative of the Ministry of Economic Affairs and Intelligent Finance Bureau ¾ According to the above-mentioned blending ratio, first, put materials other than soy bean salad oil into a container that can be heated by a blender and use The propeller stirrer is heated to 90 ° C with stirring at 100 rpm, and the product temperature is stirred at 90 ° C for 25 minutes. Then it is cooled to 20 ° C and mixed with soybean salad oil to make a lettuce salad dressing The obtained seasoning for lettuce salad is a product with a European olive flavor and good quality. Example 3 The crude hawthorn acid fraction obtained in Production Example 1 for lettuce salad 3.0 g of water 46.6 g of xanthan gum O.lg fructose glucose solution Sugar 5.0g This paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) -89- 200300069 Printed A7 B7 by the Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs, A7 B7, invention description (4 MSG 0.3g rice vinegar (acidity 10% acidity) ) 10.0g pepper soy bean salad oil 32.0g According to the above blending ratio, first put materials other than soy bean salad oil into a container equipped with a stirrer for heating, and use a propeller stirrer to stir at 100 rpm and heat to 90 ° C. Stir the product at 90 ° C for 25 minutes. Let it cool to 20 ° C and mix it with soy salad oil to make lettuce. Salad dressing. Example 4 Concentrate obtained in Production Example 2 3.0g honey 15.0g citrate O.lg dl-malic acid O.lg D-sorbitol solution (70%) 10.Og sodium benzoate O.lg perfume refined Water makes the total amount to 100g. The above ingredients are mixed uniformly to produce a healthy material. Example 5: The paper size is applicable to China National Standards (CNS) A4 size (210X297 mm) (Please read the note on the back first) Please fill in this page again for matters) -90- 200300069 A7 B7 V. Description of the invention (cocadiol 3.0g printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economy 3.0g honey 15.Og citrate 0.1 g dl-malic acid lg D-Sorbitol solution (70%) 10.Og Sodium benzoate o.lg A suitable amount of purified water to make the total i mixed the above ingredients uniformly to obtain health 1 Example 6 22.5g ursolic acid in pellet food granules 4.5g L-anti-blood acid 2_lg paste, appropriate amount of fragrance, appropriate amount of pigment, appropriate amount of the materials are mixed according to the above-mentioned blending ratio, and the mixture is directly made into a tablet shape by powder compression method to obtain a tablet-shaped food weighing 250 mg per capsule. Example 7 Soft capsule shape Food Betulinic Acid 2.0g ( Please read the notes on the back before filling this page) This paper size is applicable to Chinese National Standard (CNS) A4 specification (210X297mm) -91-200300069 A7 B7 V. Description of the invention (14.0g honey wax saffron oil 84.0g ( (Please read the precautions on the back and fill in this page first) After heating and dissolving the honey wax and saffron oil and mixing uniformly, slowly add betulinic acid under cooling, stir, and return to normal temperature. Packed in gelatin soft capsules, _ dried to obtain Soft capsule-like food. Example 8 Shell food 0.15g wheat flour 30. Defatted soybeans 18.5g wheat bran 15.0g wheat germ 11.5 g granulated sugar 10.0g After mixing according to the above-mentioned mixing ratio, add water to form and heat in an oven The dried glutinous glutinous food was obtained. Example 9: Dessert citrate l.Og skim milk powder 15.5g sucrose fatty acid ester l.Og spice refined refined mangoic acid 1 2.5 g This paper size applies the Chinese National Standard (CNS) A4 specification (21 OX297 mm) -92-200300069 V. Description of the invention (with granulated sugar lactose A7 B7 20.0g 60.0g Mix uniformly, granulate, and tablet-like dessert of S. Example 10 Crispy Biscuits Margarine 70.0g Granulated Sugar 40.0g Table Salt 0.7g Whole Egg 20.0g Low Gluten Flour 100.Og Refined Hawthorn Acid 2 2.0g (Please read the back Please fill in this page again.) Prepare the ingredients according to the above, mix them and divide them into 10g pieces, then bake them at 180 ° C for 15 minutes to make crackers. Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs ¾ Example 11 Frozen food 60.0g X 10 1.5g 2.5g 5.0g 1.0g 2.0g Pig black muscle slice Xanthan gum gum white powder maltodextrin seasoning refined mangoic acid 1 unit Paper size applies Chinese National Standard (CNS) A4 specification (210X297 mm) -93- 200300069 A7 B7 V. Description of invention (50.0g of bread water, appropriate amount of bread flour (please read the precautions on the back before filling this page) Alkane gum, egg white powder, maltodextrin, seasoning, and maslinic acid are mixed in water to prepare a coating liquid, which is coated around pork slices, then adhered with bread flour, and fried in soybeans at 180 ° C for 3 minutes. Fried food. Use all the above ingredients to make 10 pieces of fried food, and then cool to -30 ° C to make frozen food. Example 12 Packed food in sterilized bags Printed by the Consumer Cooperative of the Smart Finance Bureau of the Ministry of Economic Affairs (meat Part) Crushed pork 21.0g Vegetable oil 5.0g Vegetable paste 3.0g Watercress l.Og (Sauce part) Xanthan gum 0.2g Soy sauce 10.Og Miso 8.0g Sugar 6.0g Salt 4.0g Extract seasoning 0.8gPlant-based seasoning 0.8g Refined maslinic acid 2 0.8g Douban paste powder O.lg water makes the total li become 70g The paper size is applicable to Chinese National Standard (CNS) A4 (210X297 mm) -94-200300069 A7 B7 V. Description of the invention (9) | (Please read the notes on the back before filling in this page) After preparing the meat part and sauce part separately, add the meat part 30g and sauce part 70g together to 100g, and pack it in an aluminum foil sterilization bag After being sterilized by heating (120 ° C, 25 minutes), it was made into sterilization bag packaging food. Example 13 Margarine rapeseed oil 42.0g hardened rapeseed oil 42.0g water 14.0g table salt 0.5g lecithin 0.5g monoglycerin Esters 0.4 g refined maslinic acid 1 0.6 g Flavor appropriate amount of carotene glucosin trace amount Ministry of Economic Affairs, Intellectual Property Office / i Bureau Consumer Cooperatives Co. ¾ The above raw materials are mixed in accordance with a general method, and the blender is used for rapid cold mixing to prepare margarine. Paper size applies Chinese National Standard (CNS) A4 specification (210 × 297 mm) -95- 200300069 A7 B7 V. Description of the invention (4 Example 14 US Milk Nourishing Soybean Salad Oil 74.0 g water 8.4 g granulated sugar l.Og bran Sodium 0.3g mustard powder 0.3g table salt l.Og brewed rice vinegar 4.0g refined hawthorn acid 2 l.Og salted egg yolk 10.Og (Please read the precautions on the back before filling this page) Staff of the Intellectual Property Bureau of the Ministry of Economic Affairs Consumption cooperation seal ¾ According to the above blending ratio, first, soy bean salad oil and raw materials other than salted egg yolk are mixed and heated to 90t, and kept at 90 ° C for 25 minutes. After cooling to 2 ° C, mix soy bean salad oil, add salted egg yolks, and stir under reduced pressure to obtain beautiful milk. Using the anti-fat food for foods of the present invention does not require the burden of time or labor. The pentacyclic triterpenes and their physiologically acceptable salts or their derivatives are simply and continuously ingested, and as a result, their anti-puffiness effect can be obtained. In addition, the pentacyclic triterpenes in the present invention can be obtained by Made of natural materials, so it feels safe to use. This paper size applies the Chinese National Standard (CNS) A4 specification (210X 297 mm) -96-

Claims (1)

200300069 A8 B8 C8 D8 6. Scope of patent application 1 (Please read the precautions on the back before filling out this page) 1 · A kind of anti-plump food, which is characterized by containing pentacyclic triterpenes, and its physiological characteristics Permissible salts or derivatives of selected compounds. 2. A kind of proliferative food for suppressing proliferative adipocytes, which comprises pentacyclic triterpenes, and compounds selected from the group consisting of physiologically acceptable salts or derivatives thereof. 3. —A kind of proliferative food for inhibiting the differentiation of precursor adipocytes, which is characterized by containing a compound selected from the group consisting of pentacyclic triterpenes and physiologically acceptable salts or derivatives thereof. 4. A gluten-containing food for inhibiting fat accumulation in mature adipocytes, which is characterized by containing pentacyclic triterpenes and a compound selected from the group consisting of physiologically acceptable salts or derivatives thereof. 5. For example, the gluten-resistant food for plumpness in item 1 of the scope of patent application, in which pentacyclic triterpenes are oleanolane triterpenes, ursane triterpenes, and lupinane triterpenes It is selected from the group consisting of olefins. Printed by the Yellow Property Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 6. For example, in the case of applying for patent No. 1, the penetrating triterpenes are maslinic acid, cocadiol, ursolic acid, and bear Fruit alcohol, betulin or betulin. 7. For example, the anti-fertilization food for gluten-free foods in the scope of patent application No. 6, which contains maslinic acid and / or physiologically acceptable salts thereof. 8. The fertility-resistant glutinous food according to item 1 of the scope of patent application, wherein the compound selected from the group consisting of pentacyclic triterpenes, physiologically acceptable salts and derivatives thereof is selected from natural raw materials. Extracted. 9. For example, the anti-fattiness food for food in item 1 of the scope of patent application, in which five paper sizes are used in accordance with China National Standard (CNS) A4 (210X297 mm) -97-200300069 A8 B8 C8 D8 _ 6 2. Scope of patent application 2 (Please read the notes on the back before filling out this page) Cyclotriterpenes, the compounds selected from the group of physiologically acceptable salts and their derivatives are extracted from natural raw materials. , Concentrated and / or separated and refined. 10. The fertility-resistant gluten-free food according to item 丨 of the application, wherein the compound selected from the group consisting of pentacyclic triterpenes, physiologically acceptable salts and derivatives thereof is selected from natural raw materials. Extraction treatment, purely obtained from the obtained extract. Π · —A kind of anti-fattiness food for glutinous rice, which is characterized in that it contains defatted substances from olive olive plants, and olive olive extract or olive olive oil is the active ingredient. 1 2. The fermented food for preventing fullness as claimed in item 11 of the scope of patent application, wherein the olive oil plant extract is an extract obtained by extracting the defatted product obtained in the manufacturing process of olive oil with water and / or an organic solvent. 13. For example, the anti-plumbing foods for which the scope of the patent application is item 1, wherein the foods are water-based foods. Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs. 14. For example, the anti-fertilization food for gluten-free foods in the scope of patent application No. 1 consists of pentacyclic triterpenes, physiologically acceptable salts and derivatives thereof. The content rate of the compound selected in the group is 0.00001 to 90% by mass based on the total mass of the yam food. 15. —A compound prepared from processed oils or processed fats and oils, which contains pentacyclic triterpenes, physiologically acceptable salts, and compounds selected from the group consisting of derivatives thereof. 16. For example, the compounded fats or oils or processed fats and oils processed according to item 15 of the scope of patent application, wherein 100 g of the product contains pentacyclic triterpenes, physiologically acceptable salts and derivatives thereof. The content is from 0.001 to 10 g. This paper size applies Chinese National Standard (CNS) A4 specification (210X 297 mm) -98- 200300069 B8 C8 D8 VI. Application for patent scope 3 1 7. —A kind of anti-fattiness foods, which are characterized by the use of such as patent application It is prepared by blending fats and oils and / or processed fats and oils in the scope of item 15. (Please read the precautions on the back before filling this page) 18. —A kind of glutinous food for anti-hypertrophy and / or over-hypertrophy, which is characterized by containing pentacyclic triterpenes and its physiological It is a compound selected from the group consisting of salts and derivatives thereof. 19. A food for preventing obesity and / or treating obesity, characterized by containing pentacyclic triterpenes, physiologically acceptable salts and compounds selected from the group consisting of derivatives thereof. 20. A gluten-free food for weight loss, which is characterized by containing a compound selected from the group consisting of pentacyclic triterpenes, physiologically acceptable salts thereof, and derivatives thereof. 21. A kind of gluten-free food for improving body mass, which is characterized by containing compounds selected from the group consisting of pentacyclic triterpenes, physiologically acceptable salts and derivatives thereof. This paper uses the Chinese National Standard (CNS) A4 specification (210X297 mm) -99- 200300069 (1). The representative representative of the case is: (2) The component representative symbols of the representative diagram are simply explained: If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention: One 3 —