TR200100331T2 - Kamptotesin türevlerinin az bir gastrointestinal toksisite ile kullanımı - Google Patents
Kamptotesin türevlerinin az bir gastrointestinal toksisite ile kullanımıInfo
- Publication number
- TR200100331T2 TR200100331T2 TR2001/00331T TR200100331T TR200100331T2 TR 200100331 T2 TR200100331 T2 TR 200100331T2 TR 2001/00331 T TR2001/00331 T TR 2001/00331T TR 200100331 T TR200100331 T TR 200100331T TR 200100331 T2 TR200100331 T2 TR 200100331T2
- Authority
- TR
- Turkey
- Prior art keywords
- camptothecin derivatives
- gastrointestinal toxicity
- little
- little gastrointestinal
- gastro
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
- 206010059024 Gastrointestinal toxicity Diseases 0.000 title 1
- 231100000414 gastrointestinal toxicity Toxicity 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Gastro-intestinal yollarinin asgari düzeyde yan etkilere maruz kalmasina sebebiyet verecek sekilde, gastro-intestinal yollarin kanserlerinin tedavisine yönelik ilaçlarin hazirlanmasi için kamptotesin kurüvlerinin kullanilmasi olup, sözü geçen ilacin uygulanmasi esnasinda veya böyle bir uygulamadan önce ve böyle bir uygulama esnasinda bir sodyum klorür solüsyonunun uygulanmasi ile tanimlanir.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9810043A FR2782009B1 (fr) | 1998-08-05 | 1998-08-05 | Utilisation de derives de la comptothecine, avec une toxicite gastro-intestinale reduite |
US9631898P | 1998-08-12 | 1998-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200100331T2 true TR200100331T2 (tr) | 2001-07-23 |
Family
ID=26234482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2001/00331T TR200100331T2 (tr) | 1998-08-05 | 1999-08-03 | Kamptotesin türevlerinin az bir gastrointestinal toksisite ile kullanımı |
Country Status (24)
Country | Link |
---|---|
US (1) | US6476043B1 (tr) |
EP (1) | EP1102594B1 (tr) |
JP (1) | JP2002522392A (tr) |
KR (1) | KR20010072228A (tr) |
AT (1) | ATE217531T1 (tr) |
AU (1) | AU771195B2 (tr) |
BG (1) | BG64641B1 (tr) |
CA (1) | CA2340020A1 (tr) |
CZ (1) | CZ295775B6 (tr) |
DE (1) | DE69901506T2 (tr) |
DK (1) | DK1102594T3 (tr) |
EA (1) | EA002917B1 (tr) |
EE (1) | EE04264B1 (tr) |
ES (1) | ES2176009T3 (tr) |
GE (1) | GEP20043254B (tr) |
HU (1) | HUP0103314A3 (tr) |
ID (1) | ID27253A (tr) |
IL (1) | IL141232A0 (tr) |
NO (1) | NO20010454D0 (tr) |
NZ (1) | NZ509859A (tr) |
PT (1) | PT1102594E (tr) |
SK (1) | SK1732001A3 (tr) |
TR (1) | TR200100331T2 (tr) |
WO (1) | WO2000007605A1 (tr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1189637B1 (en) | 1999-05-17 | 2006-08-23 | Cancer Research Ventures Limited | Compositions for improving bioavailability of orally administered drugs |
CA2295429A1 (en) * | 2000-01-06 | 2001-07-06 | Michael Michael | Treatment or prevention of diarrhea |
JP4451850B2 (ja) * | 2004-02-13 | 2010-04-14 | 株式会社ヤクルト本社 | カンプトテシン類含有水溶液製剤 |
US20050197355A1 (en) * | 2004-03-02 | 2005-09-08 | Henegar Kevin E. | Compounds useful in preparing camptothecin derivatives |
MXPA06012145A (es) * | 2004-04-27 | 2007-01-31 | Wellstat Biologics Corp | Tratamiento del cancer utilizando virus y camptotecinas. |
JP2006151950A (ja) * | 2004-11-05 | 2006-06-15 | Oto Corporation:Kk | 納豆菌培養エキス含有製剤及び納豆菌培養エキスの保存方法 |
DE602006009901D1 (de) * | 2005-02-07 | 2009-12-03 | Fermion Oy | Verfahren zur herstellung von 7-ethyl-10-hydroxycamptothecin |
WO2006084940A1 (en) * | 2005-02-08 | 2006-08-17 | Fermion Oy | Process for producing [1,4'] bipiperidinyl-1'-carbonyl chloride or hydrochloride thereof |
US7767813B2 (en) * | 2005-02-08 | 2010-08-03 | Fermion Oy | Preparation method |
CA2503099A1 (en) * | 2005-04-18 | 2006-10-18 | Kabushiki Kaisha Yakult Honsha | Pharmaceutical compositions containing camptothecins |
EP1907015B1 (en) | 2005-07-14 | 2012-01-11 | Wellstat Biologics Corporation | Cancer treatment using viruses, fluoropyrimidines and camptothecins |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4284579A (en) * | 1979-07-17 | 1981-08-18 | The United States Of America As Represented By The Of The Department Of Health & Human Services | (N-Phosphonacetyl-L-aspartato)(1,2-diaminocyclchexane)platinum(II) or alkali metal salt |
US4399276A (en) * | 1981-01-09 | 1983-08-16 | Kabushiki Kaisha Yakult Honsha | 7-Substituted camptothecin derivatives |
JPS58154582A (ja) * | 1982-03-10 | 1983-09-14 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体およびその製造法 |
JPS6019790A (ja) * | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
CH663353A5 (de) * | 1984-03-28 | 1987-12-15 | Joaquin Amat Larraz | Mittel gegen krebs. |
CA1332413C (en) * | 1987-06-25 | 1994-10-11 | Kabushiki Kaisha Yakult Honsha | Camptothecin derivatives and process for preparing same |
US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
US5225404A (en) | 1989-11-06 | 1993-07-06 | New York University | Methods of treating colon tumors with tumor-inhibiting camptothecin compounds |
IT1247937B (it) * | 1991-05-16 | 1995-01-05 | Ist Naz Ric Sul Cancro | Associazione farmaceutica ad attivita' antineoplastica |
JP3359955B2 (ja) * | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
WO1996011005A2 (en) | 1994-10-06 | 1996-04-18 | Atlas Leon T | Use of camptothecin or derivatives thereof for the manufacture of a medicament for the treatment of viral diseases |
-
1999
- 1999-08-03 DE DE69901506T patent/DE69901506T2/de not_active Expired - Fee Related
- 1999-08-03 EP EP99936674A patent/EP1102594B1/fr not_active Expired - Lifetime
- 1999-08-03 JP JP2000563290A patent/JP2002522392A/ja active Pending
- 1999-08-03 CZ CZ2001382A patent/CZ295775B6/cs not_active IP Right Cessation
- 1999-08-03 PT PT99936674T patent/PT1102594E/pt unknown
- 1999-08-03 CA CA002340020A patent/CA2340020A1/fr not_active Abandoned
- 1999-08-03 EA EA200100214A patent/EA002917B1/ru unknown
- 1999-08-03 WO PCT/FR1999/001916 patent/WO2000007605A1/fr not_active Application Discontinuation
- 1999-08-03 GE GEAP19995779A patent/GEP20043254B/en unknown
- 1999-08-03 US US09/762,092 patent/US6476043B1/en not_active Expired - Fee Related
- 1999-08-03 IL IL14123299A patent/IL141232A0/xx unknown
- 1999-08-03 TR TR2001/00331T patent/TR200100331T2/tr unknown
- 1999-08-03 SK SK173-2001A patent/SK1732001A3/sk unknown
- 1999-08-03 KR KR1020017001471A patent/KR20010072228A/ko not_active Application Discontinuation
- 1999-08-03 AU AU51687/99A patent/AU771195B2/en not_active Ceased
- 1999-08-03 ES ES99936674T patent/ES2176009T3/es not_active Expired - Lifetime
- 1999-08-03 EE EEP200100066A patent/EE04264B1/xx not_active IP Right Cessation
- 1999-08-03 ID IDW20010273A patent/ID27253A/id unknown
- 1999-08-03 NZ NZ509859A patent/NZ509859A/en unknown
- 1999-08-03 DK DK99936674T patent/DK1102594T3/da active
- 1999-08-03 AT AT99936674T patent/ATE217531T1/de not_active IP Right Cessation
- 1999-08-03 HU HU0103314A patent/HUP0103314A3/hu unknown
-
2001
- 2001-01-26 NO NO20010454A patent/NO20010454D0/no not_active Application Discontinuation
- 2001-02-05 BG BG105216A patent/BG64641B1/bg unknown
Also Published As
Publication number | Publication date |
---|---|
PT1102594E (pt) | 2002-10-31 |
EP1102594B1 (fr) | 2002-05-15 |
IL141232A0 (en) | 2002-03-10 |
AU5168799A (en) | 2000-02-28 |
CZ2001382A3 (en) | 2001-05-16 |
ES2176009T3 (es) | 2002-11-16 |
NO20010454L (no) | 2001-01-26 |
KR20010072228A (ko) | 2001-07-31 |
CA2340020A1 (fr) | 2000-02-17 |
NO20010454D0 (no) | 2001-01-26 |
EA002917B1 (ru) | 2002-10-31 |
DE69901506T2 (de) | 2002-11-28 |
EP1102594A1 (fr) | 2001-05-30 |
HUP0103314A2 (hu) | 2002-01-28 |
BG105216A (en) | 2001-10-31 |
SK1732001A3 (en) | 2001-06-11 |
DE69901506D1 (de) | 2002-06-20 |
EA200100214A1 (ru) | 2001-08-27 |
ID27253A (id) | 2001-03-22 |
GEP20043254B (en) | 2004-06-25 |
WO2000007605A1 (fr) | 2000-02-17 |
HUP0103314A3 (en) | 2002-07-29 |
DK1102594T3 (da) | 2002-08-26 |
EE200100066A (et) | 2002-06-17 |
BG64641B1 (bg) | 2005-10-31 |
ATE217531T1 (de) | 2002-06-15 |
CZ295775B6 (cs) | 2005-11-16 |
NZ509859A (en) | 2003-09-26 |
US6476043B1 (en) | 2002-11-05 |
JP2002522392A (ja) | 2002-07-23 |
EE04264B1 (et) | 2004-04-15 |
AU771195B2 (en) | 2004-03-18 |
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