TH3025C3 - Production process for dispersing accelerator in tablets - Google Patents

Abstract

Production process for dispersing accelerator in tablets Using the method of producing substances from the cob Corn or sunflower stems with low production cost prices. Short-term, easy-to-use, uncomplicated use of agricultural waste that can add multiple times the value The substance was mixed in proportion to Key ingredients and other ingredients They were prepared as a tablet (compressed tablet) as a placebo. Pharmacopeia XX and United States Pharmacopeia 23 are used as a dispersant in tablets. In addition, a comparison was made. The results of the test with the disintegrant in the currently available tablet disintegrant were starch or Explotab (formulation). The results of the tablet disintegration time test showed that: When using the same filler Can give the time value of the dispersion of Much shorter pills

Claims (3)

1. Process for dispersing accelerator in tablets produced from corn cobs or sunflower trunks, the steps are as follows: 1.1 Take the dried corn cobs to coarse grinding. Or take fresh sunflower stems to peel off the skin Then dried before being coarse grinding Then coarsely ground corncobs or sunflower stems are then dried completely in a temperature controlled oven. If the temperature is 50-60 degrees Celsius, it will take up to 5 days and then grind with a grinding cutter. Passed through the mineral with a hole size of approximately 800 microns, called corncob powder or sunflower stalk powder. Medium concentration Bases used as strong bases such as sodium hydroxide By mixing cob powder Corn or sunflower stem powder Dry to water at a ratio of 1:30 add 2.5 v / v of 10 N sodium hydroxide blended together. Set aside for 2 hours, separate the solution. Then bleach it by using bleach at medium concentration. Bleaching agent used such as sodium hypochlorite by adding 0.6% sodium hypochlorite solution, soaking for 3 hours at 60 ° C, repeat 3-4 cycles, then filtering to collect sediment. 1.3 Remove the sediment. According to clause 1.2, rinse with plenty of deionized water, test the efficiency of washing with pH measurement, chlorite test. And the detection of starch, rinsing is completed when the pH of the water before and after rinsing has not changed and chlorite is not detected. And / or starch in water and in sediment 1.4 Remove the washed sediment in item 1.3 and add distilled water and mix it to look like a suspended sludge. Residue is removed by cleaning the sediment from corncob powder or stalk powder. Sunflower in a large amount of water 6 cycles by a homogenizer (homogenizer) until the pH is measured and found that the pH is between 5-7.5, including the detection Bleach residue was not found. All of this requires 6 or more rinsing cycles so no residue is found, then centrifuged with a smaller sludge granulator. Sediment collection frame 1.5: the sediment from item 1.4 is dried and then screened with ore with an opening hole size of approximately 600 microns and are then dried in a hot air oven at a temperature of 30 degrees Celsius and then selected. Size with a mineral with a hole size of about 500 microns and baking again. One to dry completely. 1.6 Grind to powder again. Will get dried corncob powder or dried sunflower stem powder at Used as dispersing agent in tablets They are kept in a sealed, dry container with moisture-proof material. 2. The production of dispersant accelerator in tablets according to claim No. 1 will obtain dry corncob powder with the following physical properties: Physical properties Results Observations of microscopic characteristics 200-500 (formula) m Observed appearance White powder, odorless, tasteless Acidity-base (pH) 6.8 Soluble in water 0.4% Powder (starch) Not detected angle of repose (degree) 40.6 (formula) 1.1 Powder density in normal condition Bulk density ( g / m) 0.29 (formula) 0.01 Tapped density (g / m) 0.36 (formula) 0.01% Impact strength (% compressibility) 19.44 Swelling capacity 1.8% Result (% yield) 36.7 3. Karma V, the production of dispersant accelerator in tablets according to claim 1, will get dried sunflower stem powder with the following physical properties: Physical properties Result Observation Microstructure 100-700 um Observed White powder, odorless, tasteless Acidity - alkali (pH) 6.8 Soluble in water 1.3% Starch Not detected angle of repose (degree) 39.6 (formula) 0.2 Powder density in normal condition Bulk density ( g / m) 0.29 (formula) 0.01 Tapped density (g / m) 0.35 (formula) 0.01% Impact strength (% compressibility) 19.44 Swelling capacity 2.2% result (% yield) 24.3