SU904518A3 - Способ получени полипептидов - Google Patents
Способ получени полипептидов Download PDFInfo
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- SU904518A3 SU904518A3 SU772470259A SU2470259A SU904518A3 SU 904518 A3 SU904518 A3 SU 904518A3 SU 772470259 A SU772470259 A SU 772470259A SU 2470259 A SU2470259 A SU 2470259A SU 904518 A3 SU904518 A3 SU 904518A3
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- USSR - Soviet Union
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- 238000005886 esterification reaction Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- IIEWJVIFRVWJOD-UHFFFAOYSA-N ethyl cyclohexane Natural products CCC1CCCCC1 IIEWJVIFRVWJOD-UHFFFAOYSA-N 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- ARBOVOVUTSQWSS-UHFFFAOYSA-N hexadecanoyl chloride Chemical compound CCCCCCCCCCCCCCCC(Cl)=O ARBOVOVUTSQWSS-UHFFFAOYSA-N 0.000 description 1
- YWGHUJQYGPDNKT-UHFFFAOYSA-N hexanoyl chloride Chemical compound CCCCCC(Cl)=O YWGHUJQYGPDNKT-UHFFFAOYSA-N 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- RBTARNINKXHZNM-UHFFFAOYSA-K iron trichloride Chemical compound Cl[Fe](Cl)Cl RBTARNINKXHZNM-UHFFFAOYSA-K 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- UKVIEHSSVKSQBA-UHFFFAOYSA-N methane;palladium Chemical compound C.[Pd] UKVIEHSSVKSQBA-UHFFFAOYSA-N 0.000 description 1
- ZGONRPXUNVTWTA-UHFFFAOYSA-N methyl 2-isocyanatoacetate Chemical compound COC(=O)CN=C=O ZGONRPXUNVTWTA-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000012716 precipitator Substances 0.000 description 1
- 238000006722 reduction reaction Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000012258 stirred mixture Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- IOGXOCVLYRDXLW-UHFFFAOYSA-N tert-butyl nitrite Chemical compound CC(C)(C)ON=O IOGXOCVLYRDXLW-UHFFFAOYSA-N 0.000 description 1
- 239000012414 tert-butyl nitrite Substances 0.000 description 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- ORQXBVXKBGUSBA-QMMMGPOBSA-N β-cyclohexyl-alanine Chemical class OC(=O)[C@@H](N)CC1CCCCC1 ORQXBVXKBGUSBA-QMMMGPOBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C07K14/702—Enkephalins with at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB14362/76A GB1523812A (en) | 1976-04-08 | 1976-04-08 | Polypeptide |
| GB2106376 | 1976-05-21 | ||
| GB2205576 | 1976-05-27 | ||
| GB2929876 | 1976-07-14 | ||
| GB4483876 | 1976-10-28 | ||
| GB4483776 | 1976-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU904518A3 true SU904518A3 (ru) | 1982-02-07 |
Family
ID=27546664
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772470259A SU904518A3 (ru) | 1976-04-08 | 1977-04-08 | Способ получени полипептидов |
Country Status (13)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2730851A1 (de) * | 1976-07-19 | 1978-01-26 | Sandoz Ag | Neu polypeptidderivate, ihre herstellung und verwendung |
| FR2359817A1 (fr) * | 1976-07-27 | 1978-02-24 | Reckitt & Colmann Prod Ltd | Nouveaux peptides, leur procede de preparation et composition therapeutique les contenant |
| PT66982B (en) * | 1976-09-01 | 1979-02-13 | Coy David Howard | Process for preparing novel methionine enkephalin derivatives |
| HU178001B (en) * | 1976-09-16 | 1982-02-28 | Gyogyszekutato Intezet | Process for preparing new pentapeptides with morphine-like activity and derivatives thereof |
| US4259234A (en) * | 1976-09-27 | 1981-03-31 | Eli Lilly And Company | Analgesic compounds |
| DE2752341A1 (de) * | 1976-11-23 | 1978-05-24 | Wellcome Found | Biologisch wirksame amide, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische formulierungen |
| DE2862327D1 (en) * | 1977-07-22 | 1983-11-10 | Wellcome Found | Pentapeptide-n-alkylamides and their acid addition salts, methods for preparation of these compounds and pharmaceutical formulations containing them |
| GB1604850A (en) * | 1977-11-24 | 1981-12-16 | Wellcome Found | Biologically active peptides |
| US4178371A (en) * | 1977-12-15 | 1979-12-11 | Reckitt & Colman Products Limited | Tetrapeptide derivatives |
| FR2424253A1 (fr) * | 1978-04-27 | 1979-11-23 | Brun Lab Sa Le | Nouveaux derives de peptides analogues des enkephalines, leur procede de preparation et leur application therapeutique |
| US4278596A (en) * | 1978-08-08 | 1981-07-14 | American Home Products Corporation | Analgesic pentapeptides |
| CA1175810A (en) * | 1979-03-30 | 1984-10-09 | Frank A. Momany | Synthetic peptides having pituitary growth hormone releasing activity |
| DE2933947A1 (de) * | 1979-08-22 | 1981-03-12 | Hoechst Ag, 6000 Frankfurt | Neue peptidamide und verfahren zu ihrer herstellung. |
| JPS5692846A (en) * | 1979-12-27 | 1981-07-27 | Takeda Chem Ind Ltd | Tetrapeptide derivative and its preparation |
| FR2488253A1 (fr) * | 1980-08-08 | 1982-02-12 | Roques Bernard | Nouveaux peptides et leur application en therapeutique |
| US4495178A (en) * | 1983-10-06 | 1985-01-22 | G. D. Searle & Co. | Enkephalin analogs |
| JP2604268B2 (ja) * | 1990-04-09 | 1997-04-30 | 富士写真フイルム株式会社 | ペプチド誘導体両親媒性化合物、その中間体、ペプチド誘導体両親媒性化合物を用いたリポソームおよび薄膜 |
| EP1975153A3 (en) * | 2003-05-30 | 2010-03-31 | Prozymex A/S | Protease inhibitors |
| JP6149279B2 (ja) * | 2011-02-09 | 2017-06-21 | オーガノバランス ゲーエムベーハー | 皮膚状態の治療に使用するためのペプチド |
| JP2013043885A (ja) * | 2011-08-26 | 2013-03-04 | Kansai Bunri Sogo Gakuen | デヒドロアミノ酸含有グリセロール誘導体 |
| CZ303858B6 (cs) * | 2012-05-11 | 2013-05-29 | Zetor Tractors A.S. | Usporádání reverzacní dvoutoké prevodovky, zejména pro motorová vozidla a stavební stroje, s dvema vetvemi toku výkonu |
| CA3082827A1 (en) | 2017-11-17 | 2019-05-23 | Cytogel Pharma, Llc | Polymer agonists of mu opioid receptors |
-
1977
- 1977-03-28 NZ NZ183712A patent/NZ183712A/xx unknown
- 1977-03-31 AU AU23819/77A patent/AU510760B2/en not_active Expired
- 1977-04-04 FI FI771049A patent/FI771049A7/fi not_active Application Discontinuation
- 1977-04-06 DK DK158077A patent/DK158077A/da not_active IP Right Cessation
- 1977-04-06 SE SE7704043A patent/SE7704043L/ not_active Application Discontinuation
- 1977-04-06 HU HU77IE774A patent/HU176260B/hu unknown
- 1977-04-06 CS CS772289A patent/CS202568B2/cs unknown
- 1977-04-07 DE DE19772715803 patent/DE2715803A1/de not_active Withdrawn
- 1977-04-07 DD DD7700198316A patent/DD130348A5/xx unknown
- 1977-04-07 FR FR7710668A patent/FR2347336A1/fr active Granted
- 1977-04-08 SU SU772470259A patent/SU904518A3/ru active
- 1977-04-08 PL PL1977197302A patent/PL106210B1/pl unknown
- 1977-04-08 JP JP4023077A patent/JPS52139039A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2347336B1 (enrdf_load_stackoverflow) | 1980-07-18 |
| NZ183712A (en) | 1979-10-25 |
| AU510760B2 (en) | 1980-07-10 |
| PL197302A1 (pl) | 1978-02-13 |
| JPS52139039A (en) | 1977-11-19 |
| PL106210B1 (pl) | 1979-12-31 |
| DE2715803A1 (de) | 1977-10-27 |
| FR2347336A1 (fr) | 1977-11-04 |
| DK158077A (da) | 1977-10-09 |
| DD130348A5 (de) | 1978-03-22 |
| FI771049A7 (enrdf_load_stackoverflow) | 1977-10-09 |
| CS202568B2 (en) | 1981-01-30 |
| HU176260B (en) | 1981-01-28 |
| SE7704043L (sv) | 1977-10-09 |
| AU2381977A (en) | 1978-10-05 |
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