SU579853A3 - Apparatus for artificial ventilation of lungs - Google Patents

Apparatus for artificial ventilation of lungs

Info

Publication number
SU579853A3
SU579853A3 SU7402063442A SU2063442A SU579853A3 SU 579853 A3 SU579853 A3 SU 579853A3 SU 7402063442 A SU7402063442 A SU 7402063442A SU 2063442 A SU2063442 A SU 2063442A SU 579853 A3 SU579853 A3 SU 579853A3
Authority
SU
USSR - Soviet Union
Prior art keywords
valve
pressure
bellows
inlet
multivibrator
Prior art date
Application number
SU7402063442A
Other languages
Russian (ru)
Inventor
Кеннет Рассель Жорж
Original Assignee
Сандос А.Г., (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US401739A priority Critical patent/US3916889A/en
Application filed by Сандос А.Г., (Фирма) filed Critical Сандос А.Г., (Фирма)
Application granted granted Critical
Publication of SU579853A3 publication Critical patent/SU579853A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057Pumps therefor
    • A61M16/0081Bag or bellow in a bottle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M16/0009Accessories therefor, e.g. sensors, vibrators, negative pressure with sub-atmospheric pressure, e.g. during expiration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0003Accessories therefor, e.g. sensors, vibrators, negative pressure
    • A61M16/0009Accessories therefor, e.g. sensors, vibrators, negative pressure with sub-atmospheric pressure, e.g. during expiration
    • A61M16/0012Accessories therefor, e.g. sensors, vibrators, negative pressure with sub-atmospheric pressure, e.g. during expiration by Venturi means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/0057Pumps therefor
    • A61M16/0075Bellows-type
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/10Preparation of respiratory gases or vapours
    • A61M16/105Filters
    • A61M16/106Filters in a path
    • A61M16/107Filters in a path in the inspiratory path
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/42Reducing noise

Description

one
The invention relates to medical technology.
A pulmonary ventilator is known, which contains devices for connecting with an oxygen source, inspiration volume regulators, minute zinc-cops ventilator with a syphon with a load, a high-pressure switching valve, breathing patient's warmth hose, pneumatic control logic | including a standby multivibrator with two stable positions, respectively, with two plugs and several opposite inputs, two timers, respectively, inhalation and exhalation with hermetic chambers, having readers mounted for movement, to form an output signal, the outputs of which are connected to the inputs of the standby multivibrator , adjustable relief valves, connected to a sealed chamber, and reset controlled valves, auxiliary ventilation unit, devices for limiting inhalation pressure and volume with sensitivity controllers, tserekpyuyatpep Operational modes of the device,
controllable and self-acting inlet and exhaust valves connected to a high pressure switch valve.
However, such an apparatus does not provide artificial respiration with any predetermined concentration of oxygen,
The purpose of the invention is to provide artificial respiration with any given oxygen concentration.
The goal is achieved by the fact that the apparatus is equipped with a mixing valve installed between the syphon inlet valve and bellows, the mixing valve connected to the surrounding atmosphere, and through the inlet valve to an oxygen source, a device for generating a positive final expiratory pressure with an outlet connected to the inlet of the auxiliary unit continuous flow ventilation: a tank, an adjustable displacement discharge valve associated with a flow tank, a controlled shutter connected to a pressure valve ohm bias and having an inlet valve controlled by a multivibrator zhauschim
Moreover, the inhalation and expiratory time relays are inserted in the form of a sealed joint and a snoophone located inside the hermetic © mKOCTHj and the device for moving the contacts of these relays is made in the form of a rod with a pair of cupboards installed on it
In this case, the auxiliary fan unit and the pressure limiting device each include three proportional amplifiers connected in series, and three jet waiting multivibrators connected in series, with the output of the amplifiers.
In addition, the device is equipped with manual switches from exhalation to BDOC and back, connected to the opposite inputs of the waiting multivibrator, and three indicators connected respectively to the output of the auxiliary ventilation unit to the output of the pressure limiting device and the inspiratory time relay.
FIG. 1 is a functional diagram of the ventilator of FIG. 2 - 4ush; rational pneumatic logic circuit, on the fng. 3 - inhalation and exhalation time relays; front view with partial paapeaoMj in FIG. 4 - the same, side view. ,
The pulmonary ventilator contains devices 1 for connecting with an oxygen source, a ruler for 2 volumes, a regulator for 3 minutes of ventilation, a bell 4 with a syphon 5 with load 6 in it, a high-pressure switching valve 7, a breathing hose 8 for a patient Pneumatic control logic circuit 9 includes standby multivibrator 10 with two stable positions, respectively with two outputs and several PROT1SH POSITIVE inputs, two relays 11 and 12 respectively of inhalation and exhalation with hermetic chambers Frames 13 and 14, with readers 15 and 16, mounted for movement to form an output signal, the outputs of which are connected to the inputs of the waiting multivibrator Yu, adjustable bypass valves 17 connected to a sealed chamber, and resetting control valves 18.
 In addition, the device contains an auxiliary ventilation unit 19, a pressure limiting device 20, a device 21 limiting and inspiratory volumes corresponding to sensitivity regulators 22 and 23, a switch 24 operating modes of the device, controlling self-acting inlet 25 and exhaust 26 valves connected to valve 7 high pressure switching.
The device is equipped with a mixing valve 27, installed between the inlet valve (2P.) And the junction 5, the mixing valve is connected to the surrounding atmosphere, and through the inlet valve to the oxygen source | a positive end expiratory pressure generation device 28 with an outlet 29 connected to the inlet of the auxiliary ventilation unit 19 having a flow tank 30, an adjustable mixing pressure valve 31 connected to the flow tank, controlled by a shutter 32 connected to a displacement discharge valve 33 and having a valve the inlet 34 controlled by the waiting multivibrator Yu, j Relay 11 and 12 of the inhalation and expiratory times are made in the form of sealed chambers 13 and 14 and the bellows 35 inside the sealed container, and the movement device yvateley these relays designed as a rod 36, on which a pair of cams 37 mounted,
The auxiliary ventilation unit 19 and the inspiratory pressure limiting device 20 each comprise three proportional amplifiers connected in series, and tricyclic stand-by multivibrators 4143 connected in series and with an output of amplifiers.
The device is also equipped with manual switches 44 and 45 from exhalation to inhalation and back, connected to the opposite inputs of the waiting multivibrator 10, and three indicators 46-48 connected respectively to the output of the auxiliary ventilation unit 19, the output of the pressure limiting device 2O and. to relay 11 inspiratory time.
The device works as follows. During the inhalation cycle, air from the bellows device is supplied to the patient's breathing hose through the exhaust valve 26. The bellows 5 is surrounded by a limited space of the bell and is released from air as a result of the supply of oxygen under pressure to this limited space, which is compressed by the sylph. The load 6 is located at the free lower end of the bellows device so that with the weakening of the oxygen pressure in the space surrounding the bellows, it automatically acts on this device. Under the action of the load, the bellows are expanded and, as a result, squeezes oxygen from the confined space and through the mixing valve 27, where oxygen either exits into the atmosphere or mixes with the supplied ambient air and is then injected into an expanding bellows device for use in a subsequent inspiration cycle. Through the inlet valve 25, the mixing valve communicates with the confined space surrounding the bellows, with the Buskoy and the exhaust valve of the bellows device being alternately activated during the inhalation or expiratory cycling cycle according to the logic of the mixing injection valve 33, which is connected to one output of the waiting multivibrator. 10.- The latter, in turn, pi is controlled by one input by the signal of the expiratory time relay 12 and the automatic signal of the block 19, and through the other input by the signal of the inhalation time relay 11, s a signal, a pressure limiting device 20, and a signal from the breath restriction device 21 associated with the bellows device.
The device can operate in three different modes of operation (assistance and / or control), which are manually activated with a pneumatic switch. Under the Breath Assist mode, switch 24 is connected; for actuation with auxiliary ventilation unit 19, which, together with 20, pressure limiting device 2O responds to pressure in the patient control line 49 so that the multivibrator: 1O switches to the position for adjusting the inhalation cycles and. expiration, bellows 25 device in accordance with the needs of patient i breathing. So, for example, when the air pressure in the patient control line 49 drops to a level indicating the end of the inspiration cycle, this level is detected by the DA unit 19, which then starts the main waiting multivibrator 1O, and that it caused the inspiratory cycle of the bellows device. Then, during the Help mode, the pressure limiting device 2O sends a trigger signal to the main waiting multivibrator 10 to stop the inspiration cycle if the pressure in the patient control line exceeds the set value. At the same time, device 21 for limiting 40 Inspiratory volume in the bellows device also sends a trigger signal to the main one. waiting for multivibrator 1O to endorse the inhalation cycle after a specified maximum amount of air arrives at the patient's organization from the bellows device, or the time relay sends a trigger signal to the main waiting multivibrator to end the inhalation cycle after a specified period of time. Consequently, the first of the 50 signals of the occurrence, volume, or time reaching its specified maximum, triggers a zhavushiy multivibrator so that it aconts the inspiration cycle; The command from 19 stops cipher vyaeha.55
When the switch is turned on, the Help mode is energized (to the exhalation time, the block 19 is energized, that the waiting multivibrator Yu at the opposite input is controlled by the turn-off time output (e} w exhale, and at the other 60
 - inhalation time relay n inhalation limiting device. Accordingly, in the Assist mode, the expiration cycle is automatically controlled, as is the inspiration cycle, but the latter also stops before the output of the inspiratory time relay signal, if the pressure limiting device signal or the limiting device signal (Volume has reached its predetermined maximum values.
The volume of the bellows 5, intended for supplying air to the patient, is regulated by n limited by the movable plate 5O, which also contributes to the limitation of the space surrounding the bellows.
During the inspiratory cycle, the valve 17 is controlled by the multivibrator 1O and the oxygen is pumped into a limited space, thereby compressing the bellows 5. Then, when the pressure drops in this space, the bellows expands under the action of the load 6 on it; in this case, oxygen is squeezed out of this space, which passes through valve 17, switched to the open position by means of scheme 9. A mixing valve 27, through which oxygen passes from valve 17, is adjusted to pass the required amount of oxygen through the bellows with a simultaneous partial flow of the filtered clod. cotton air. Room air enters at normal pressure and is sucked into the bellows due to the vacuum caused by the expansion of the latter. However, oxygen is supplied under pressure from a confined space under pressure, so that the mixing valve regulates the oxygen content in the gas supplied to the stifon in the range of 21-1OO%.
Each time switch includes a bellows 5, placed in an inlet-open chamber, to supply oxygen at a predetermined pressure in order to cause a temporary compression of the bellows. The rod 51 is at one end attached to the movable end of the bellows 5, while the other end closes the opening in the inspiratory volume restriction device 21.
Each chamber 13 and 14 surrounding the bellows 35, is provided with a set 1ymi therein derailing valves 18, poddayuschimis adjusting opposite output monostable multivibrator 10, so that as soon as the back pressure detector sends the output signal dn switching monostable multiiibratorp, the resulting signal at the output of monostable multivibrator provides reverse smiling l with this bellows chamber for the purpose of resetting in it the posting and preparation for the next cycle of timing. Both cameras are installed adjacent and their elements are knockaiyn prodvodvaganeni - with the possibility of pereovizhenie VA springs. When the rod is rotated, both sensors are rotated and are also rotated. Thus, this movement of the sensing elements intercepts the periods of counting the time of exhalation and inhalation, which can be castroed simultaneously by rotating the rod. In addition, in parallel with the inlet in the turnips; inhalation time, a bypass valve 17 is included, which can open to shorten the inhalation time in order to adjust the inhalation / exhalation (B / B ratios). In the time relay, the I / O ratio does not exceed one.
Auxiliary ventilation UNIT 19 and pressure limiting device 20 have similar designs, each including a more universal trigger circuit for automatic operation in an oxygen device for patients. Depending on the input compounds, it can produce an output signal as I response to a small pressure difference at its outputs, an output signal as a response to pressure, slightly lower than the external signal caused by the patient’s breathing efforts, an output signal as a response to pressure levels above or below. below atmospheric pressure (the device is automatically shifted so that it can be used in conjunction with the exhalation pressure signals), the output signal as a response to the input air pressure signals Indicating the maximum levels, the output signal in response to the flow of the signals or rate of change of pressure, it is sometimes necessary ..
In accordance with the use of universal trigger circuits, partially regulated by final expiratory pressure signals, the circuits are used to generate a signal as a response to a small pressure difference. In order for positive end delivery pressures (PKDV) to be used under the Assist Breathing mode without the need for breathing effort from the patient's side, to return the pressure in the patient's breathing hose to external pressure, the PKDV pressure is passed through the diaphragm valve to the auxiliary ventilation unit 19 to displacing this module so that it can be started at pressure in the control line 49 of the patient above the level of external pressure.

Claims (4)

  1. Claims 1. Mechanical ventilation apparatus containing devices for connection
    with a source of oxygen regulators of inspiratory volume, minute ventilation, a bell with a load bellows in it, a high pressure switching valve, a patient breathing hose, a pneumatic paddle control circuit, including a standby multivibrator with two stable positions mGg with two outlets and several opposite inputs, two time relays, respectively, inhalation and exhalation with hermetic chambers, having readers} installed with the possibility of a mixture of a signal vyhoschl are connected to inputs of monostable multivibrator, controlled relief valves connected to the sealed chamber, and discharging controllable valves; auxiliary ventilator unit for limiting pressure and inspiratory volume with sensitivity controls; an apparatus mode switch, controlled self-acting inlet and outlet valves connected to a high pressure thermostat valve, characterized in that, in order to provide artificial respiration with any given oxygen concentration, it is equipped with a mixing valve installed between the inlet valve of the bellows and the bellows, the mixing valve being connected to the surrounding atmosphere, and through an acceleration valve with an oxygen source, a positive end expiratory pressure device with an outlet connected to the inlet of the auxiliary ventilation unit, having a flow tank, an adjustable displacement discharge valve, connected with the flow capacity, a controlled gate, connected to the Haiv non-voltage bias valve and having a valve inlet, driven by standby multivibrator.
  2. 2. The device according to claim 1, so that the inhalation and exhalation time relays are made in the form of a sealed container and bellows inside the sealed container, and the device for moving the readers of these relays is made in the form of rod with a pair of cams mounted on it,
  3. 3. The apparatus according to claim 1, characterized in that the auxiliary ventilation unit and the inlet pressure limiting device each comprise three proportional amplifiers connected in series and three jet waiting multivibrators connected in series and with an output of amplifiers.
  4. 4. The device according to claim 1, 1 and 2 with the fact that it is equipped with manual overshoots from exhalation to inhale and back, connected to the opposite inputs of the waiting multivibrator, and three indicators connected respectively to the output auxiliary ventilation unit, the output of pressure control set-up and the turn-in time of inspiration
    37
    36
    ig. four
SU7402063442A 1973-09-28 1974-09-27 Apparatus for artificial ventilation of lungs SU579853A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US401739A US3916889A (en) 1973-09-28 1973-09-28 Patient ventilator apparatus

Publications (1)

Publication Number Publication Date
SU579853A3 true SU579853A3 (en) 1977-11-05

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ID=23589024

Family Applications (1)

Application Number Title Priority Date Filing Date
SU7402063442A SU579853A3 (en) 1973-09-28 1974-09-27 Apparatus for artificial ventilation of lungs

Country Status (15)

Country Link
US (1) US3916889A (en)
JP (1) JPS5063795A (en)
BE (1) BE820457A (en)
CA (1) CA1014040A (en)
CH (1) CH585551A5 (en)
DD (1) DD116556A5 (en)
DE (1) DE2446055A1 (en)
DK (1) DK494074A (en)
ES (1) ES430505A1 (en)
FR (1) FR2271806B1 (en)
GB (1) GB1488358A (en)
IT (1) IT1022370B (en)
NL (1) NL7412628A (en)
SE (1) SE398044B (en)
SU (1) SU579853A3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003326A1 (en) * 1981-03-26 1982-10-14 Kiszel Janos Respirator device particularly for use in perinatal medicine

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4057059A (en) * 1975-07-29 1977-11-08 Oklahoma State University Intermittent positive pressure breathing device
US4060078A (en) * 1975-08-18 1977-11-29 Bird F M Ventilator and method
US4003377A (en) * 1975-08-21 1977-01-18 Sandoz, Inc. Patient ventilator
US4098272A (en) * 1975-09-25 1978-07-04 Bio-Med Devices Inc. Respirator
US4141356A (en) * 1976-06-16 1979-02-27 Bourns, Inc. Respirator system and method
US4148312A (en) * 1976-10-08 1979-04-10 Minnesota Mining And Manufacturing Company Combination anesthesia and intensive care apparatus
US4155357A (en) * 1976-12-10 1979-05-22 Sandoz, Inc. Patient ventilator disconnect alarm
JPS5447900U (en) * 1977-09-09 1979-04-03
US4197843A (en) * 1978-04-03 1980-04-15 Minnesota Mining And Manufacturing Company Volume limiting ventilator
DE3126207C2 (en) * 1981-07-03 1983-11-17 Draegerwerk Ag, 2400 Luebeck, De
US4448192A (en) * 1982-03-05 1984-05-15 Hewlett Packard Company Medical ventilator device parametrically controlled for patient ventilation
US4459982A (en) * 1982-09-13 1984-07-17 Bear Medical Systems, Inc. Servo-controlled demand regulator for respiratory ventilator
US4702240A (en) * 1986-07-22 1987-10-27 Bear Medical Systems, Inc. Demand-responsive gas blending system for medical ventilator
US4931285A (en) * 1988-04-28 1990-06-05 Alza Corporation Aqueous based pharmaceutical coating composition for dosage forms
US5111809A (en) * 1988-12-01 1992-05-12 Avstar Aerospace Corporation Breathing system
DE3900276C2 (en) * 1989-01-07 1991-08-08 Draegerwerk Ag, 2400 Luebeck, De
US5086767A (en) * 1990-09-26 1992-02-11 Canadian Aging & Rehabilitation Product Development Corporation Ventilator for assisting the breathing of a patient
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
IL110014A (en) * 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
GB2282542B (en) * 1993-10-06 1997-06-25 Instruments & Movements Ltd Ventilators for promoting lung function
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
US5411745A (en) * 1994-05-25 1995-05-02 Euro-Celtique, S.A. Powder-layered morphine sulfate formulations
US6077533A (en) * 1994-05-25 2000-06-20 Purdue Pharma L.P. Powder-layered oral dosage forms
GB9422154D0 (en) * 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
FI974148A (en) 1997-11-05 1999-05-06 Instrumentarium Oy Method and apparatus of a breathing apparatus
PT1685839E (en) 1997-12-22 2013-07-08 Euro Celtique Sa Pharmaceutical oral dosage form comprising a combination of an opioid agonist and opioid antagonist
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
DE69822208T2 (en) * 1997-12-29 2005-04-28 Alza Corp., Mountain View OSMOTIC ADMINISTRATION SYSTEM WITH PUSHROOM RESTRAINT MECHANISM
WO1999033513A1 (en) 1997-12-31 1999-07-08 Alza Corporation Osmotic drug delivery monitoring system and method
TW407058B (en) 1998-07-17 2000-10-01 Dev Center Biotechnology Oral cisapride dosage forms with an extended duration
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
KR100889069B1 (en) 1999-10-29 2009-03-17 유로-셀티크 소시에떼 아노뉨 Controlled release hydrocodone formulations
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
CZ299991B6 (en) 2000-02-08 2009-01-14 Euro-Celtique S.A. Medicamentous dosage form
IL151058D0 (en) 2000-02-08 2003-04-10 Euro Celtique Sa Controlled-release compositions containing opioid agonist and antagonist
WO2002036099A1 (en) 2000-10-30 2002-05-10 Euro-Celtique S.A. Controlled release hydrocodone formulations
EP1387673B1 (en) 2001-05-11 2010-12-29 Endo Pharmaceuticals Inc. Abuse-resistant controlled-release opioid dosage form
US20030044458A1 (en) 2001-08-06 2003-03-06 Curtis Wright Oral dosage form comprising a therapeutic agent and an adverse-effect agent
US20030068375A1 (en) 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
KR20040029405A (en) 2001-08-06 2004-04-06 유로-셀티크 소시에떼 아노뉨 Opioid agonist formulations with releasable and sequestered antagonist
WO2003013433A2 (en) 2001-08-06 2003-02-20 Euro-Celtique S.A. Sequestered antagonist formulations
US7387123B2 (en) * 2001-11-30 2008-06-17 Viasys Manufacturing, Inc. Gas identification system and volumetrically correct gas delivery system
EP2339328A3 (en) 2002-12-30 2011-07-13 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of celecoxib
PT2425825T (en) 2002-04-05 2017-02-13 Euro-Celtique S A Pharmaceutical preparation containing oxycodone and naloxone
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
DE60335426D1 (en) 2002-08-15 2011-01-27 Euro Celtique Sa Pharmaceutical compositions containing an opioid antagonist
US7267120B2 (en) 2002-08-19 2007-09-11 Allegiance Corporation Small volume nebulizer
PT1551372T (en) 2002-09-20 2018-07-23 Alpharma Pharmaceuticals Llc Sequestering subunit and related compositions and metohds
EP2218448B1 (en) 2002-12-13 2015-09-23 Durect Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
TWI347201B (en) 2003-04-21 2011-08-21 Euro Celtique Sa Pharmaceutical products,uses thereof and methods for preparing the same
EP2298303A1 (en) 2003-09-25 2011-03-23 Euro-Celtique S.A. Pharmaceutical combinations of hydrocodone and naltrexone
ES2515092T3 (en) 2003-12-11 2014-10-29 Sunovion Pharmaceuticals Inc. Combination of a sedative and a neurotransmitter modulator and methods of improving sleep quality and treating depression
BRPI0606339A2 (en) * 2005-01-28 2009-06-16 Euro Celtique Sa alcohol resistant dosage forms
EP1604666A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
WO2005123039A1 (en) 2004-06-12 2005-12-29 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
WO2006007351A2 (en) * 2004-06-28 2006-01-19 Alza Corporation Squeeze controlled oral dosage form
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
EP1813276A1 (en) * 2006-01-27 2007-08-01 Euro-Celtique S.A. Tamper resistant dosage forms
KR101486228B1 (en) 2006-06-19 2015-01-26 알파마 파머슈티컬스 엘엘씨 Pharmaceutical compositions
EP2019101A1 (en) * 2007-07-26 2009-01-28 GPC Biotech AG Pyrazol[3,4-d]pyrimidin-4-one useful as Kinase Inhibitor
EP3326621A1 (en) 2007-12-06 2018-05-30 Durect Corporation Oral pharmaceutical dosage forms
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
AR074760A1 (en) * 2008-12-18 2011-02-09 Metabolex Inc GPR120 RECEIVER AGONISTS AND USES OF THE SAME IN MEDICINES FOR THE TREATMENT OF DIABETES AND METABOLIC SYNDROME.
US9271940B2 (en) 2009-03-10 2016-03-01 Purdue Pharma L.P. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
PT2826467T (en) 2010-12-22 2017-10-25 Purdue Pharma Lp Encased tamper resistant controlled release dosage forms
BR112013015939A2 (en) 2010-12-23 2020-08-04 Purdue Pharma L.P. adulteration-resistant solid oral dosage forms
WO2013049332A1 (en) 2011-09-29 2013-04-04 Infinity Pharmaceuticals, Inc. Inhibitors of monoacylglycerol lipase and methods of their use
CN105120846B (en) 2013-02-05 2019-10-18 普渡制药公司 The pharmaceutical preparation of anti-distort
US9572885B2 (en) 2013-03-15 2017-02-21 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
WO2015011189A1 (en) 2013-07-23 2015-01-29 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
MX2016009300A (en) 2014-01-15 2017-04-13 Rhodes Tech Process for improved oxycodone synthesis.
US10232130B2 (en) 2015-03-26 2019-03-19 Becton, Dickinson And Company Anti-run dry membrane
US10201667B2 (en) 2015-03-26 2019-02-12 Becton, Dickinson And Company IV membrane attachment systems and methods
US10702689B2 (en) 2015-03-26 2020-07-07 Becton, Dickinson And Company Auto-stop vent plug
US10646648B2 (en) 2015-04-01 2020-05-12 Becton, Dickinson And Company IV flow management systems and methods
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations
US10820833B2 (en) 2016-12-09 2020-11-03 Physio-Control, Inc. Capnograph system further detecting spontaneous patient breaths

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1162151A (en) * 1966-02-24 1969-08-20 Watson W & Sons Ltd Improvements in or relating to Medical Respirators
GB1328087A (en) * 1969-09-15 1973-08-30 Pye Ltd Pneumatically controlled medical respirators
US3669108A (en) * 1969-10-20 1972-06-13 Veriflo Corp Ventilator
GB1248303A (en) * 1970-01-02 1971-09-29 Pye Ltd Improvements in or relating to medical respirators
US3730180A (en) * 1970-10-21 1973-05-01 Mine Safety Appliances Co Pneumatically operated ventilator
US3756229A (en) * 1970-12-14 1973-09-04 Veriflo Corp Ventilator

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1982003326A1 (en) * 1981-03-26 1982-10-14 Kiszel Janos Respirator device particularly for use in perinatal medicine

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ES430505A1 (en) 1976-10-01
FR2271806A1 (en) 1975-12-19
SE7411865L (en) 1975-04-01
DD116556A5 (en) 1975-12-05
GB1488358A (en) 1977-10-12
DE2446055A1 (en) 1975-04-03
NL7412628A (en) 1975-04-02
CA1014040A (en) 1977-07-19
FR2271806B1 (en) 1979-02-16
CH585551A5 (en) 1977-03-15
SE398044B (en) 1977-12-05
JPS5063795A (en) 1975-05-30
DK494074A (en) 1975-05-26
BE820457A1 (en)
CA1014040A1 (en)
BE820457A (en) 1975-01-16
IT1022370B (en) 1978-03-20
US3916889A (en) 1975-11-04

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