SU465786A3 - Способ получени соли 4-хлор-м-толуол или 3,4-дихлорбензолсульфокислоты и -форм пропоксифена - Google Patents
Способ получени соли 4-хлор-м-толуол или 3,4-дихлорбензолсульфокислоты и -форм пропоксифенаInfo
- Publication number
- SU465786A3 SU465786A3 SU1804380A SU1804380A SU465786A3 SU 465786 A3 SU465786 A3 SU 465786A3 SU 1804380 A SU1804380 A SU 1804380A SU 1804380 A SU1804380 A SU 1804380A SU 465786 A3 SU465786 A3 SU 465786A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- chloro
- propoxyphene
- salt
- toluene
- preparing
- Prior art date
Links
- WIWQDBABYGRKEW-UHFFFAOYSA-N 3,4-dichlorobenzenesulfonic acid Chemical compound OS(=O)(=O)C1=CC=C(Cl)C(Cl)=C1 WIWQDBABYGRKEW-UHFFFAOYSA-N 0.000 title description 8
- 238000000034 method Methods 0.000 title description 6
- HKCFHDMLRDLQSN-UHFFFAOYSA-N 4-chloro-3-methylbenzenesulfonic acid Chemical compound CC1=CC(S(O)(=O)=O)=CC=C1Cl HKCFHDMLRDLQSN-UHFFFAOYSA-N 0.000 title 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 229960004193 dextropropoxyphene Drugs 0.000 description 5
- 150000003839 salts Chemical class 0.000 description 5
- -1 4-chloro-l-toluenesulfonic acid salt Chemical class 0.000 description 4
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- 150000001342 alkaline earth metals Chemical class 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- XLMALTXPSGQGBX-GCJKJVERSA-N dextropropoxyphene Chemical compound C([C@](OC(=O)CC)([C@H](C)CN(C)C)C=1C=CC=CC=1)C1=CC=CC=C1 XLMALTXPSGQGBX-GCJKJVERSA-N 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 229940065347 propoxyphene hydrochloride Drugs 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-M 2-methylbenzenesulfonate Chemical compound CC1=CC=CC=C1S([O-])(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 150000003460 sulfonic acids Chemical class 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N toluene Substances CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/32—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of salts of sulfonic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C219/22—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15812671A | 1971-06-29 | 1971-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU465786A3 true SU465786A3 (ru) | 1975-03-30 |
Family
ID=22566784
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1804380A SU465786A3 (ru) | 1971-06-29 | 1972-06-28 | Способ получени соли 4-хлор-м-толуол или 3,4-дихлорбензолсульфокислоты и -форм пропоксифена |
Country Status (22)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5312970A (en) * | 1989-05-26 | 1994-05-17 | Mallinckrodt Specialty Chemicals Company | Method of preparing D-propoxyphene |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2728779A (en) * | 1952-12-03 | 1955-12-27 | Lilly Co Eli | Esters of substituted aminobutanes |
| US3065261A (en) * | 1960-12-14 | 1962-11-20 | Lilly Co Eli | Pharmaceutical salts |
| US3395146A (en) * | 1965-02-11 | 1968-07-30 | Warner Lambert Pharmaceutical | 4-substituted-2-benzhydryl-2-butanol derivatives |
-
1971
- 1971-06-29 US US00158126A patent/US3728379A/en not_active Expired - Lifetime
-
1972
- 1972-06-13 CA CA144,555A patent/CA966844A/en not_active Expired
- 1972-06-13 IE IE828/72A patent/IE36416B1/xx unknown
- 1972-06-13 ZA ZA724042A patent/ZA724042B/xx unknown
- 1972-06-16 PH PH13633A patent/PH10960A/en unknown
- 1972-06-16 IL IL39702A patent/IL39702A/xx unknown
- 1972-06-20 AT AT531772A patent/AT315821B/de not_active IP Right Cessation
- 1972-06-23 NL NL7208708A patent/NL7208708A/xx unknown
- 1972-06-26 DD DD163977A patent/DD100242A5/xx unknown
- 1972-06-27 ES ES72404317A patent/ES404317A1/es not_active Expired
- 1972-06-27 PL PL1972156308A patent/PL84890B1/pl unknown
- 1972-06-28 SU SU1804380A patent/SU465786A3/ru active
- 1972-06-28 GB GB3023372A patent/GB1392004A/en not_active Expired
- 1972-06-28 DE DE2231665A patent/DE2231665A1/de active Pending
- 1972-06-28 HU HUEI423A patent/HU165527B/hu unknown
- 1972-06-28 DK DK323372AA patent/DK136973B/da unknown
- 1972-06-28 BE BE785517A patent/BE785517A/xx unknown
- 1972-06-28 CH CH970072A patent/CH574391A5/xx not_active IP Right Cessation
- 1972-06-28 SE SE7208513A patent/SE387937B/xx unknown
- 1972-06-29 FR FR7223615A patent/FR2143893B1/fr not_active Expired
- 1972-06-29 AR AR242826A patent/AR193273A1/es active
- 1972-06-29 AU AU44085/72A patent/AU462738B2/en not_active Expired
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