SU264621A1 - Method of obtaining injection solution-gelatin - Google Patents

Method of obtaining injection solution-gelatin

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Publication number
SU264621A1
SU264621A1 SU1216047A SU1216047A SU264621A1 SU 264621 A1 SU264621 A1 SU 264621A1 SU 1216047 A SU1216047 A SU 1216047A SU 1216047 A SU1216047 A SU 1216047A SU 264621 A1 SU264621 A1 SU 264621A1
Authority
SU
USSR - Soviet Union
Prior art keywords
gelatin
solution
method
injection solution
obtaining injection
Prior art date
Application number
SU1216047A
Other languages
Russian (ru)
Publication of SU264621A1 publication Critical patent/SU264621A1/en

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Description

This invention relates to the field of medicine, namely to methods for preparing an injection solution of gelatin.

A method is known for preparing a gelatin injection solution. By adding chicken eggs, table salt and activated carbon to a solution of dry gelatin, basifying and subsequent autoclaving.

The solution obtained in this way is pyrogenic.

In order to obtain a pyrogen-free injection solution, the gelatin solution is preheated for 40-45 minutes. at 80-85 ° C and pH 9.0-9.5.

Example. 40 liters of cold distilled water is poured into the porcelain container, 10 kg of gelatin is added, mixed and left to swell for 20 minutes. Then distilled water heated to 80-95 ° C is added to obtain the required concentration, stirred until the gelatin is dissolved, and the solution of the solution is adjusted to 9.3-9.6 by adding an lOVc solution of sodium hydroxide. The resulting solution is pumped into a hydrolysis apparatus, in which it is heated with steam to 80-85 ° C and stirred for 45 minutes at this temperature. The mixture is then cooled to 60 ° C by the addition of a 10% solution.

hydrochloric acid is adjusted to pH 7.3-7.5 and freshly prepared protein from 200 chicken eggs, 0.5 kg of boiled salt and 8 kg of activated charcoal is added. The resulting mixture is heated to 60 ° C, maintained at this

temperature is 30 minutes, heated to 105 ° C and maintained at this temperature in a pressure of 0.4 MPa for 15 minutes. After autoclaving, the solution is filtered, poured into ampoules and sterilized.

Subject i h o f e t e i

The method of obtaining gelatin injection solution by adding to the solution of dry gelatin chicken protein,

salts and activated carbon, alkalization and subsequent autoclaving, characterized in that, in order to obtain a pyrogen-free solution, the gelatin solution is preheated for 40-45 minutes at 80-85 ° C

and pI 9.0-9.5.

SU1216047A Method of obtaining injection solution-gelatin SU264621A1 (en)

Publications (1)

Publication Number Publication Date
SU264621A1 true SU264621A1 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability

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