SK286851B6 - Spôsob priemyselnej syntézy esterov N-[(S)-1-karboxybutyl]-(S)- alanínu a ich použitie pri syntéze perindoprilu - Google Patents

Spôsob priemyselnej syntézy esterov N-[(S)-1-karboxybutyl]-(S)- alanínu a ich použitie pri syntéze perindoprilu Download PDF

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Publication number
SK286851B6
SK286851B6 SK1405-2002A SK14052002A SK286851B6 SK 286851 B6 SK286851 B6 SK 286851B6 SK 14052002 A SK14052002 A SK 14052002A SK 286851 B6 SK286851 B6 SK 286851B6
Authority
SK
Slovakia
Prior art keywords
formula
synthesis
compound
perindopril
process according
Prior art date
Application number
SK1405-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK14052002A3 (sk
Inventor
Jean-Claude Souvie
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of SK14052002A3 publication Critical patent/SK14052002A3/sk
Publication of SK286851B6 publication Critical patent/SK286851B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1405-2002A 2000-03-31 2001-03-30 Spôsob priemyselnej syntézy esterov N-[(S)-1-karboxybutyl]-(S)- alanínu a ich použitie pri syntéze perindoprilu SK286851B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004112A FR2807037B1 (fr) 2000-03-31 2000-03-31 NOUVEAU PROCEDE DE SYNTHESE DES ESTERS DE LA N-[(s)-1- CARBOXYBUTYL]-(S)-ALANINE ET APPLICATION A LA SYNTHESE DU PERINDOPRIL
PCT/FR2001/000959 WO2001056353A2 (fr) 2000-03-31 2001-03-30 Nouveau procede de synthese de esters de la n-[(s)-1-carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Publications (2)

Publication Number Publication Date
SK14052002A3 SK14052002A3 (sk) 2003-02-04
SK286851B6 true SK286851B6 (sk) 2009-06-05

Family

ID=8848711

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1405-2002A SK286851B6 (sk) 2000-03-31 2001-03-30 Spôsob priemyselnej syntézy esterov N-[(S)-1-karboxybutyl]-(S)- alanínu a ich použitie pri syntéze perindoprilu

Country Status (36)

Country Link
US (1) US6818788B2 (hu)
EP (1) EP1268398B1 (hu)
JP (1) JP3930322B2 (hu)
KR (1) KR100498869B1 (hu)
CN (1) CN1171855C (hu)
AP (1) AP1483A (hu)
AR (1) AR027754A1 (hu)
AT (1) ATE297377T1 (hu)
AU (2) AU2001248433B2 (hu)
BG (1) BG65832B1 (hu)
BR (1) BRPI0109609B1 (hu)
CA (1) CA2404700C (hu)
CZ (1) CZ302840B6 (hu)
DE (1) DE60111364T2 (hu)
DK (1) DK1268398T3 (hu)
EA (1) EA004314B1 (hu)
EE (1) EE05079B1 (hu)
ES (1) ES2242743T3 (hu)
FR (1) FR2807037B1 (hu)
GE (1) GEP20063796B (hu)
HK (1) HK1053301A1 (hu)
HR (1) HRP20020860B1 (hu)
HU (1) HU229188B1 (hu)
ME (1) ME00437B (hu)
MX (1) MXPA02009378A (hu)
NO (1) NO328064B1 (hu)
NZ (1) NZ521324A (hu)
OA (1) OA12324A (hu)
PL (1) PL199714B1 (hu)
PT (1) PT1268398E (hu)
RS (1) RS50239B (hu)
SI (1) SI1268398T1 (hu)
SK (1) SK286851B6 (hu)
UA (1) UA73562C2 (hu)
WO (1) WO2001056353A2 (hu)
ZA (1) ZA200207150B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) * 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DK1603558T3 (da) 2003-02-28 2008-09-01 Servier S A Lab Fremgangsmåde til fremstilling af perindopril og salte deraf
ATE445588T1 (de) * 2003-09-01 2009-10-15 Servier Lab Neues verfahren zur herstellung von estern des n- ((s)-1-carboxybutyl)-(s)-alanins und seine verwendung in der synthese von perindopril
ES2256693T3 (es) * 2003-09-30 2006-07-16 Les Laboratoires Servier Procedimiento de sintesis de n-((s)-1-(etoxicarbonil)butil)-(s)-alanina y su utilizacion en la sintesis de perindopril.
SI1403278T1 (en) * 2003-09-30 2005-10-31 Les Laboratoires Servier Process for the synthesis of N-((S)-1-(ethoxycarbonyl)butyl)-(S)-alanine and use in the synthese of perindopril
EP1729739B1 (en) * 2004-03-29 2016-09-28 Les Laboratoires Servier Process for preparing a solid pharmaceutical composition
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) * 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
WO2006006183A2 (en) * 2004-07-12 2006-01-19 Matrix Laboratories Ltd An improved process for the preparation of n-[(s)-ethoxycarbonyl-l-butyl]-(s)-alanine
EP1792896A1 (en) 2005-12-01 2007-06-06 KRKA, tovarna zdravil, d.d., Novo mesto Process for the preparation of perindopril and salts thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4247716A (en) * 1977-09-02 1981-01-27 Mitsui Toatsu Chemicals, Inc. Process for producing pyruvic acid
FR2620699B1 (fr) * 1987-09-17 1990-06-01 Adir Procede de synthese d'alpha amino acides n alkyles et de leurs esters. application a la synthese de carboxyalkyl dipeptides
FR2620709B1 (fr) * 1987-09-17 1990-09-07 Adir Procede de synthese industrielle du perindopril et de ses principaux intermediaires de synthese
FR2807430B1 (fr) * 2000-04-11 2002-05-17 Adir Nouveau procede de synthese des esters de la n-[(s)-1- carboxybutyl]-(s)-alanine et application a la synthese du perindopril

Also Published As

Publication number Publication date
US6818788B2 (en) 2004-11-16
FR2807037A1 (fr) 2001-10-05
BRPI0109609B1 (pt) 2015-04-14
DE60111364D1 (de) 2005-07-14
HU229188B1 (hu) 2013-09-30
HUP0101335A3 (en) 2002-11-28
MXPA02009378A (es) 2003-02-12
YU73202A (sh) 2006-03-03
HK1053301A1 (en) 2003-10-17
RS50239B (sr) 2009-07-15
AP2002002628A0 (en) 2002-09-30
CA2404700A1 (fr) 2001-08-09
UA73562C2 (uk) 2005-08-15
NO328064B1 (no) 2009-11-16
OA12324A (en) 2006-05-12
EE200200553A (et) 2004-04-15
GEP20063796B (en) 2006-04-25
FR2807037B1 (fr) 2002-05-10
HU0101335D0 (en) 2001-06-28
EP1268398B1 (fr) 2005-06-08
NO20024616D0 (no) 2002-09-26
CN1171855C (zh) 2004-10-20
AU2001248433B2 (en) 2004-10-28
NZ521324A (en) 2004-03-26
SK14052002A3 (sk) 2003-02-04
AU4843301A (en) 2001-08-14
HRP20020860A2 (en) 2004-02-29
AP1483A (en) 2005-10-31
ES2242743T3 (es) 2005-11-16
US20030045744A1 (en) 2003-03-06
EA004314B1 (ru) 2004-02-26
HUP0101335A2 (hu) 2001-11-28
HRP20020860B1 (en) 2011-02-28
WO2001056353A2 (fr) 2001-08-09
BG65832B1 (bg) 2010-02-26
CZ302840B6 (cs) 2011-12-07
PT1268398E (pt) 2005-09-30
ME00437B (me) 2011-10-10
PL199714B1 (pl) 2008-10-31
JP2003534241A (ja) 2003-11-18
NO20024616L (no) 2002-09-26
PL346554A1 (en) 2001-09-10
AR027754A1 (es) 2003-04-09
DK1268398T3 (da) 2005-10-03
EA200201027A1 (ru) 2003-02-27
EP1268398A2 (fr) 2003-01-02
KR100498869B1 (ko) 2005-07-04
ZA200207150B (en) 2003-09-05
JP3930322B2 (ja) 2007-06-13
KR20030017484A (ko) 2003-03-03
EE05079B1 (et) 2008-10-15
BG107234A (bg) 2003-07-31
SI1268398T1 (en) 2005-10-31
DE60111364T2 (de) 2006-03-16
WO2001056353A3 (fr) 2002-04-18
BR0109609A (pt) 2004-01-13
CN1420862A (zh) 2003-05-28
ATE297377T1 (de) 2005-06-15
CA2404700C (fr) 2007-02-20

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20190330