SK280845B6 - Kyselina erytro-(e)-3,5-dihydroxy-7-[3'-(4''-fluórfenyl)-1'- -(1''-metyletyl)indol-2'-yl]-hept-6-énová a spôsob jej výroby - Google Patents

Kyselina erytro-(e)-3,5-dihydroxy-7-[3'-(4''-fluórfenyl)-1'- -(1''-metyletyl)indol-2'-yl]-hept-6-énová a spôsob jej výroby Download PDF

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Publication number
SK280845B6
SK280845B6 SK5797-89A SK579789A SK280845B6 SK 280845 B6 SK280845 B6 SK 280845B6 SK 579789 A SK579789 A SK 579789A SK 280845 B6 SK280845 B6 SK 280845B6
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SK
Slovakia
Prior art keywords
formula
compound
ester
racemic
optically pure
Prior art date
Application number
SK5797-89A
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English (en)
Slovak (sk)
Other versions
SK579789A3 (en
Inventor
Kau-Ming Chen
Prasad Koteswara Kapa
George T. Lee
Oljan Repic
Petr Hess
Michel Crevoisier
Original Assignee
Novartis Ag
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26945992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK280845(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK579789A3 publication Critical patent/SK579789A3/sk
Publication of SK280845B6 publication Critical patent/SK280845B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
    • C07C223/02—Compounds containing amino and —CHO groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/48—Unsaturated compounds containing hydroxy or O-metal groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK5797-89A 1988-10-13 1989-10-12 Kyselina erytro-(e)-3,5-dihydroxy-7-[3'-(4''-fluórfenyl)-1'- -(1''-metyletyl)indol-2'-yl]-hept-6-énová a spôsob jej výroby SK280845B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25747588A 1988-10-13 1988-10-13
US35553189A 1989-05-22 1989-05-22

Publications (2)

Publication Number Publication Date
SK579789A3 SK579789A3 (en) 2000-08-14
SK280845B6 true SK280845B6 (sk) 2000-08-14

Family

ID=26945992

Family Applications (1)

Application Number Title Priority Date Filing Date
SK5797-89A SK280845B6 (sk) 1988-10-13 1989-10-12 Kyselina erytro-(e)-3,5-dihydroxy-7-[3'-(4''-fluórfenyl)-1'- -(1''-metyletyl)indol-2'-yl]-hept-6-énová a spôsob jej výroby

Country Status (24)

Country Link
EP (2) EP0562643A3 (no)
JP (1) JP2853227B2 (no)
KR (1) KR0162656B1 (no)
AT (1) ATE99281T1 (no)
AU (1) AU636122B2 (no)
BG (1) BG60555B1 (no)
CA (1) CA2000553C (no)
CZ (1) CZ283316B6 (no)
DE (1) DE68911834T2 (no)
DK (1) DK175073B1 (no)
ES (1) ES2060712T3 (no)
FI (1) FI98063C (no)
HK (1) HK49496A (no)
HU (1) HU207993B (no)
IE (2) IE63477B1 (no)
IL (1) IL91941A (no)
MY (1) MY105067A (no)
NO (1) NO174623C (no)
NZ (1) NZ230973A (no)
RO (1) RO109732B1 (no)
SG (1) SG139553A1 (no)
SK (1) SK280845B6 (no)
WO (1) WO1990003962A1 (no)
YU (1) YU48466B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118853A (en) * 1988-10-13 1992-06-02 Sandoz Ltd. Processes for the synthesis of 3-disubstituted aminoacroleins
US5290946A (en) * 1988-10-13 1994-03-01 Sandoz Ltd. Processes for the synthesis of 3-(substituted indolyl-2-yl)propenaldehydes
JPH03184961A (ja) * 1989-10-10 1991-08-12 Glaxo Group Ltd 化合物
DE4424525A1 (de) * 1994-07-12 1995-01-26 Elmar Meyer Dauermagnet-Kolbenmotor
GT199800127A (es) 1997-08-29 2000-02-01 Combinaciones terapeuticas.
RS50377B (sr) 1999-08-30 2009-11-10 Sanofi-Aventis Deutschland Gmbh., Inhibitori sistema renin-angiotenzin i njihova primena
JP2003535077A (ja) * 2000-05-26 2003-11-25 チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド インドール誘導体を製造する方法、および該方法の中間体
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
JPWO2004094377A1 (ja) * 2003-04-24 2006-07-13 ダイセル化学工業株式会社 光学活性なジヒドロキシヘプテン酸エステルの分離方法
KR20070092993A (ko) 2003-06-18 2007-09-14 테바 파마슈티컬 인더스트리즈 리미티드 플루바스타틴 나트륨 결정형 ｘｉｖ, ｌｘｘｉｉｉ,ｌｘｘｉｘ, ｌｘｘｘ 및 ｌｘｘｘｖｉｉ, 이의 제조 방법,이를 포함하는 조성물 및 이를 사용하는 방법
US7368581B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Process for the preparation of fluvastatin sodium crystal from XIV
US7368468B2 (en) 2003-06-18 2008-05-06 Teva Pharmaceutical Industries Ltd. Fluvastatin sodium crystal forms XIV, LXXIII, LXXIX, LXXX and LXXXVII, processes for preparing them, compositions containing them and methods of using them
JP2007512347A (ja) 2003-11-26 2007-05-17 デューク・ユニバーシティー 緑内障を予防するかまたは治療する方法
US7851624B2 (en) 2003-12-24 2010-12-14 Teva Pharamaceutical Industries Ltd. Triol form of rosuvastatin and synthesis of rosuvastatin
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2327668T3 (es) 2006-04-20 2009-11-02 F.I.S. Fabbrica Italiana Sintetici S.P.A. Procedimiento para la preparacion de sal sodica de fluvastatina.
EP2373609B1 (en) 2008-12-19 2013-10-16 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
JP6224624B2 (ja) 2012-02-02 2017-11-01 ザ・ユニバーシティ・オブ・シドニー 涙膜安定性における改善
CA2909442A1 (en) 2013-04-17 2014-10-23 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
MA54261A (fr) 2019-01-18 2022-04-27 Astrazeneca Ab Inhibiteurs de pcsk9 et leurs procédés d'utilisation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB945536A (en) * 1961-09-08 1964-01-02 Istituto Chemioterapico Method of preparing ª -amino-acroleins
US4739073A (en) * 1983-11-04 1988-04-19 Sandoz Pharmaceuticals Corp. Intermediates in the synthesis of indole analogs of mevalonolactone and derivatives thereof
AU570021B2 (en) * 1982-11-22 1988-03-03 Novartis Ag Analogs of mevalolactone
US4571428A (en) * 1983-07-08 1986-02-18 Sandoz, Inc. 6-Substituted-4-hydroxy-tetrahydropyran-2-ones
US4650890A (en) * 1984-04-03 1987-03-17 Sandoz Corp. Preparation of olefinic compounds and intermediates thereof
DE3582674D1 (de) * 1984-06-22 1991-05-29 Sandoz Ag Pyrazolanaloge von mevalonolakton und abkoemmlinge davon, verfahren zu deren herstellung und deren verwendung.
DE3581638D1 (de) * 1984-12-04 1991-03-07 Sandoz Ag Inden-analoga von mevalonolakton und ihre derivate.
US4668794A (en) * 1985-05-22 1987-05-26 Sandoz Pharm. Corp. Intermediate imidazole acrolein analogs
EP0244364A3 (en) * 1986-04-30 1992-04-01 Sandoz Ag Preparation of olefinic compounds
PT85662B (pt) * 1986-09-10 1990-06-29 Sandoz Sa Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem

Also Published As

Publication number Publication date
DK175073B1 (da) 2004-05-24
DE68911834D1 (de) 1994-02-10
SK579789A3 (en) 2000-08-14
IE940109L (en) 1990-04-13
CA2000553C (en) 2001-12-04
KR900701723A (ko) 1990-12-04
ATE99281T1 (de) 1994-01-15
DK144690D0 (da) 1990-06-13
YU197389A (en) 1990-12-31
WO1990003962A1 (en) 1990-04-19
FI98063B (fi) 1996-12-31
HK49496A (en) 1996-03-29
NO902598D0 (no) 1990-06-12
HU207993B (en) 1993-07-28
ES2060712T3 (es) 1994-12-01
JPH03501735A (ja) 1991-04-18
CA2000553A1 (en) 1990-04-13
NO174623B (no) 1994-02-28
DE68911834T2 (de) 1994-06-23
NO902598L (no) 1990-08-07
NZ230973A (en) 1993-03-26
EP0562643A2 (en) 1993-09-29
SG139553A1 (en) 2008-02-29
NO174623C (no) 1994-06-08
FI902935A0 (fi) 1990-06-12
MY105067A (en) 1994-07-30
KR0162656B1 (ko) 1999-01-15
BG92179A (bg) 1993-12-24
CZ283316B6 (cs) 1998-02-18
AU4344889A (en) 1990-05-01
IL91941A (en) 1994-10-21
FI98063C (fi) 1997-04-10
EP0562643A3 (en) 1994-05-18
IE63477B1 (en) 1995-04-19
EP0363934B1 (en) 1993-12-29
BG60555B1 (en) 1995-08-28
IL91941A0 (en) 1990-06-10
HUT53860A (en) 1990-12-28
RO109732B1 (ro) 1995-05-30
EP0363934A1 (en) 1990-04-18
IE893277L (en) 1990-04-13
HU896048D0 (en) 1990-11-28
AU636122B2 (en) 1993-04-22
YU48466B (sh) 1998-08-14
JP2853227B2 (ja) 1999-02-03
DK144690A (da) 1990-06-13
CZ579789A3 (en) 1997-11-12

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