SK280589B6 - Adičná sol' 3-[2-[4-(6-fluór-1,2-benzizoxazol-3-yl - Google Patents

Adičná sol' 3-[2-[4-(6-fluór-1,2-benzizoxazol-3-yl Download PDF

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Publication number
SK280589B6
SK280589B6 SK1313-95A SK131395A SK280589B6 SK 280589 B6 SK280589 B6 SK 280589B6 SK 131395 A SK131395 A SK 131395A SK 280589 B6 SK280589 B6 SK 280589B6
Authority
SK
Slovakia
Prior art keywords
pyrido
pyrimidin
tetrahydro
fluoro
ethyl
Prior art date
Application number
SK1313-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK131395A3 (en
Inventor
Jean Louis Mesens
Jozef Peeters
Original Assignee
Janssen Pharmaceutica N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.
Publication of SK131395A3 publication Critical patent/SK131395A3/sk
Publication of SK280589B6 publication Critical patent/SK280589B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/105—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic
    • C07C65/11—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
SK1313-95A 1993-04-28 1994-04-22 Adičná sol' 3-[2-[4-(6-fluór-1,2-benzizoxazol-3-yl SK280589B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93201216 1993-04-28
PCT/EP1994/001296 WO1994025460A1 (en) 1993-04-28 1994-04-22 Risperidone pamoate

Publications (2)

Publication Number Publication Date
SK131395A3 SK131395A3 (en) 1996-06-05
SK280589B6 true SK280589B6 (sk) 2000-04-10

Family

ID=8213799

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1313-95A SK280589B6 (sk) 1993-04-28 1994-04-22 Adičná sol' 3-[2-[4-(6-fluór-1,2-benzizoxazol-3-yl

Country Status (32)

Country Link
US (2) US5612346A (zh)
EP (1) EP0697019B1 (zh)
JP (1) JP3478397B2 (zh)
KR (1) KR100307101B1 (zh)
CN (1) CN1041727C (zh)
AT (1) ATE163418T1 (zh)
AU (1) AU675136B2 (zh)
BG (1) BG62004B1 (zh)
CA (1) CA2160366C (zh)
CY (1) CY2107B1 (zh)
CZ (1) CZ286688B6 (zh)
DE (1) DE69408666T2 (zh)
DK (1) DK0697019T3 (zh)
ES (1) ES2113652T3 (zh)
FI (1) FI109125B (zh)
GR (1) GR3026028T3 (zh)
HK (1) HK1006059A1 (zh)
HU (1) HU218212B (zh)
IL (1) IL109448A (zh)
LV (1) LV12315B (zh)
NO (1) NO305083B1 (zh)
NZ (1) NZ266143A (zh)
PH (1) PH30476A (zh)
PL (1) PL182466B1 (zh)
RO (1) RO115955B1 (zh)
RU (1) RU2131428C1 (zh)
SG (1) SG47046A1 (zh)
SI (1) SI9420031B (zh)
SK (1) SK280589B6 (zh)
TW (1) TW376319B (zh)
WO (1) WO1994025460A1 (zh)
ZA (1) ZA942909B (zh)

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KR100354270B1 (ko) * 1993-11-19 2003-02-11 알커메스 컨트롤드 테라포이틱스 인코퍼레이티드 Ii 마이크로캡슐화된3-피페리디닐-치환된1,2-벤즈이속사졸및1,2-벤즈이소티아졸
US5453425A (en) * 1994-07-11 1995-09-26 Janssen Pharmaceutica N.V. Risperidone oral formulation
TW487572B (en) * 1996-05-20 2002-05-21 Janssen Pharmaceutica Nv Aqueous suspensions of 9-hydroxyrisperidone fatty acid esters
CA2304568C (en) * 1997-09-30 2008-08-12 Eli Lilly And Company Olanzapine pamoate formulations
US6617321B2 (en) 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
UA72189C2 (uk) 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
HU227400B1 (en) * 1998-09-30 2011-05-30 Lilly Co Eli 2-methyl-thieno-benzodiazepine formulation and its use
WO2000027849A2 (en) * 1998-11-12 2000-05-18 Merck & Co., Inc. Therapeutic polymorphs of a gaba-a alpha-5 inverse agonist and pamoate formulations of the same
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
US6770478B2 (en) * 2000-02-10 2004-08-03 The Regents Of The University Of California Erythrocytic cells and method for preserving cells
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
WO2002043766A1 (fr) * 2000-11-29 2002-06-06 Takeda Chemical Industries, Ltd. Compositions medicinales et leur procede de preparation
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
EP1534288A1 (en) * 2002-08-23 2005-06-01 Ranbaxy Laboratories, Ltd. Stable aqueous solutions of risperidone and methods for their preparation
KR20040034996A (ko) * 2002-10-18 2004-04-29 한미약품 주식회사 리스페리돈의 개선된 제조방법
WO2004094415A1 (en) * 2003-04-22 2004-11-04 Synthon B.V. Risperidone monohydrochloride
US6987111B2 (en) * 2003-08-06 2006-01-17 Alkermes Controlled Therapeutics, Ii Aripiprazole, olanzapine and haloperidol pamoate salts
CN1870980B (zh) 2003-10-23 2010-06-23 大冢制药株式会社 控释无菌阿立哌唑注射剂和方法
WO2005053796A1 (en) * 2003-12-02 2005-06-16 B & B Beheer Nv Use of d4 and 5-ht2a antagonists, inverse agonists or partial agonists
US7884096B2 (en) * 2003-12-02 2011-02-08 Pharmaneuroboost N.V. Method of treating mental disorders using of D4 and 5-HT2A antagonists, inverse agonists or partial agonists
CA2554959A1 (en) * 2004-01-29 2005-08-11 Neuromolecular, Inc. Combination of a nmda receptor antagonist and a mao-inhibitor or a gadpf-inhibitor for the treatment of central nervous system-related conditions
PT1838716E (pt) * 2005-01-05 2011-07-15 Lilly Co Eli Di-hidrato de pamoato de olanzapina
EP1695973A1 (en) * 2005-02-24 2006-08-30 Neuro3D Ocaperidone salt and pharmaceutical compositions containing the same
AR055099A1 (es) * 2005-07-28 2007-08-08 Alza Corp Formulaciones liquidas para la administracion controlada de derivados de bencisoxazol
WO2007035348A2 (en) * 2005-09-15 2007-03-29 Elan Pharma International, Limited Nanoparticulate aripiprazole formulations
US8852638B2 (en) 2005-09-30 2014-10-07 Durect Corporation Sustained release small molecule drug formulation
NZ581862A (en) 2007-05-25 2012-06-29 Tolmar Therapeutics Inc Injectable subcutaneous formulation comprising risperidone capable of forming a solid, microporous implant in a patient
US9457026B2 (en) * 2007-07-31 2016-10-04 Otsuka Pharmaceutical Co., Ltd. Methods for producing aripiprazole suspension and freeze-dried formulation
LT2234617T (lt) * 2007-12-19 2021-05-25 Janssen Pharmaceutica Nv Dozės režimai, susiję su ilgo veikimo injekuojamais paliperidono esteriais
PL2685979T3 (pl) 2011-03-18 2017-02-28 Alkermes Pharma Ireland Limited Kompozycje farmaceutyczne do wstrzykiwania zawierające środek nierozpuszczalny w wodzie, środek przeciwpsychotyczny, laurynian sorbitanu i polisorbat 20
ES2564973T3 (es) 2011-04-26 2016-03-30 Torrent Pharmaceuticals Limited Sales por adición de ácidos de risperidona y composiciones farmacéuticas de las mismas
JP6333802B2 (ja) * 2012-03-19 2018-05-30 アルカームス ファーマ アイルランド リミテッド ベンジルアルコールを含む医薬組成物
ES2765036T3 (es) 2012-03-19 2020-06-05 Alkermes Pharma Ireland Ltd Composiciones farmacéuticas que comprenden esteres de ácidos grasos
US9993556B2 (en) 2012-03-19 2018-06-12 Alkermes Pharma Ireland Limited Pharmaceutical compositions comprising fatty glycerol esters
WO2013150055A1 (en) 2012-04-04 2013-10-10 Intervet International B.V. Solid oral pharmaceutical compositions for isoxazoline compounds
CN102659577B (zh) * 2012-04-07 2014-07-02 安徽绩溪县徽煌化工有限公司 一种亚甲基双羟基萘酸的制备方法
CA2885196C (en) 2012-09-19 2021-06-22 Alkermes Pharma Ireland Limited Pharmaceutical compositions having improved storage stability
EP2900270B1 (en) * 2012-09-26 2019-03-06 Tangent Reprofiling Limited Combination of benzo(iso)oxazolepiperidines with conjugated linoleic acid
US9375433B2 (en) 2012-09-26 2016-06-28 Tangent Reprofiling Limited Modulators of androgen synthesis
RU2688233C2 (ru) 2014-03-20 2019-05-21 Алкермес Фарма Айэленд Лимитед Препараты арипипразола, имеющие повышенные скорости впрыска
CN106831594B (zh) * 2017-01-18 2018-02-02 力赛生物医药科技（厦门）有限公司 可乐定双羟萘酸盐及其制备方法
WO2019173230A1 (en) 2018-03-05 2019-09-12 Alkermes Pharma Ireland Limited Aripiprazole dosing strategy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles

Also Published As

Publication number Publication date
SI9420031B (sl) 2002-08-31
DK0697019T3 (da) 1998-09-28
HUT72970A (en) 1996-06-28
JPH08509482A (ja) 1996-10-08
CN1121719A (zh) 1996-05-01
AU6721694A (en) 1994-11-21
WO1994025460A1 (en) 1994-11-10
ZA942909B (en) 1995-10-26
CZ286688B6 (en) 2000-06-14
KR100307101B1 (ko) 2001-11-30
AU675136B2 (en) 1997-01-23
US5612346A (en) 1997-03-18
SG47046A1 (en) 1998-03-20
TW376319B (en) 1999-12-11
HU9501934D0 (en) 1995-09-28
NZ266143A (en) 1996-07-26
JP3478397B2 (ja) 2003-12-15
CA2160366A1 (en) 1994-11-10
EP0697019A1 (en) 1996-02-21
PH30476A (en) 1997-05-28
SI9420031A (en) 1996-08-31
BG62004B1 (bg) 1998-12-30
CA2160366C (en) 2006-06-06
NO305083B1 (no) 1999-03-29
PL182466B1 (pl) 2002-01-31
RO115955B1 (ro) 2000-08-30
DE69408666D1 (de) 1998-04-02
SK131395A3 (en) 1996-06-05
NO954275D0 (no) 1995-10-26
ES2113652T3 (es) 1998-05-01
EP0697019B1 (en) 1998-02-25
FI109125B (fi) 2002-05-31
IL109448A0 (en) 1994-07-31
CN1041727C (zh) 1999-01-20
RU2131428C1 (ru) 1999-06-10
DE69408666T2 (de) 1998-06-18
LV12315A (lv) 1999-07-20
BG100094A (bg) 1996-05-31
PL311282A1 (en) 1996-02-05
US5723467A (en) 1998-03-03
NO954275L (no) 1995-10-26
CZ270695A3 (en) 1996-01-17
ATE163418T1 (de) 1998-03-15
HK1006059A1 (en) 1999-02-05
HU218212B (hu) 2000-06-28
IL109448A (en) 1997-03-18
CY2107B1 (en) 2002-04-26
LV12315B (en) 2000-03-20
FI955166A0 (fi) 1995-10-27
GR3026028T3 (en) 1998-04-30
FI955166A (fi) 1995-10-27

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MK4A Patent expired

Expiry date: 20140422