SK279168B6 - Bicyklické 1-azacykloalkány, farmaceutické prostri - Google Patents

Bicyklické 1-azacykloalkány, farmaceutické prostri Download PDF

Info

Publication number
SK279168B6
SK279168B6 SK1448-91A SK144891A SK279168B6 SK 279168 B6 SK279168 B6 SK 279168B6 SK 144891 A SK144891 A SK 144891A SK 279168 B6 SK279168 B6 SK 279168B6
Authority
SK
Slovakia
Prior art keywords
azabicyclo
bicyclic
formula
octane
alkyl
Prior art date
Application number
SK1448-91A
Other languages
English (en)
Slovak (sk)
Inventor
Gerhard Walther
Ulrike K�Fner-M�Hl
Werner Stransky
Karl-Heinz Weber
Helmut Ensinger
Franz Josef Kuhn
Enzio M�Ller
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of SK279168B6 publication Critical patent/SK279168B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
SK1448-91A 1990-05-19 1991-05-16 Bicyklické 1-azacykloalkány, farmaceutické prostri SK279168B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4016212 1990-05-19
DE4018886 1990-06-13

Publications (1)

Publication Number Publication Date
SK279168B6 true SK279168B6 (sk) 1998-07-08

Family

ID=25893382

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1448-91A SK279168B6 (sk) 1990-05-19 1991-05-16 Bicyklické 1-azacykloalkány, farmaceutické prostri

Country Status (14)

Country Link
EP (1) EP0458214A1 (pt)
JP (1) JP2853837B2 (pt)
KR (1) KR910020009A (pt)
AU (1) AU648789B2 (pt)
CA (1) CA2042860A1 (pt)
CZ (1) CZ281837B6 (pt)
FI (1) FI912409A (pt)
HU (1) HUT58091A (pt)
IE (1) IE911688A1 (pt)
IL (1) IL98176A0 (pt)
NO (1) NO911934L (pt)
PT (1) PT97703A (pt)
SK (1) SK279168B6 (pt)
YU (1) YU84791A (pt)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT97637B (pt) * 1990-05-11 1998-08-31 Sankyo Co Processo para a preparacao de derivados piperidiloxi- e quinuclidiniloxi-isoxazolicos e de composicoes farmaceuticas que os contem
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9127279D0 (en) * 1991-12-23 1992-02-19 Ici Plc Heterocyclic derivatives
AU3901393A (en) * 1992-04-10 1993-11-18 Zeneca Limited Biphenylylquinuclidine derivatives as squalene synthase inhibitors
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
IT1255179B (it) * 1992-06-26 1995-10-20 Enzo Cereda Azaciclo e azabiciclo alchiliden idrossilamine
GB9216721D0 (en) * 1992-08-06 1992-09-23 Ici Plc Therapeutic heterocyclic derivatives
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
IL107184A (en) * 1992-10-09 1997-08-14 Abbott Lab Heterocyclic ether compounds that enhance cognitive function
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5512574A (en) * 1994-12-21 1996-04-30 American Home Products Corporation Quinuclidine and azabicyclo 2.2.1! heptane pyrazinyl ethers as muscarinic agonists
US5859004A (en) * 1995-02-17 1999-01-12 Novo Nordisk A/S Use of heterocyclic compounds for the treatment of conditions caused by malfunctioning of the nicotinic cholinergic system
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
EP0874828A4 (en) * 1995-12-06 1999-09-01 Lilly Co Eli PAIN TREATMENT COMPOSITIONS
EP0912183A4 (en) * 1996-04-23 1999-08-04 Lilly Co Eli HETEROCYCLIC COMPOSITIONS
ATE384720T1 (de) * 2002-08-14 2008-02-15 Neurosearch As Chinucledin - derivate und deren verwendung
GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
WO2005016923A1 (en) 2003-08-13 2005-02-24 Neurosearch A/S Novel quinuclidine derivatives and their pharmaceutical use
US7655657B2 (en) 2003-12-22 2010-02-02 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US20050137203A1 (en) * 2003-12-22 2005-06-23 Jianguo Ji 3-quinuclidinyl amino-substituted biaryl derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
PE20060437A1 (es) * 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) 2004-07-14 2004-08-18 Novartis Ag Organic compounds
CN1922176A (zh) * 2004-12-10 2007-02-28 艾博特公司 稠合的双环杂环取代的奎宁环衍生物
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
TW202245800A (zh) 2020-02-18 2022-12-01 美商基利科學股份有限公司 抗病毒化合物
AR121356A1 (es) 2020-02-18 2022-05-11 Gilead Sciences Inc Compuestos antivirales
TWI794742B (zh) 2020-02-18 2023-03-01 美商基利科學股份有限公司 抗病毒化合物
US11697666B2 (en) 2021-04-16 2023-07-11 Gilead Sciences, Inc. Methods of preparing carbanucleosides using amides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE321933B (pt) * 1967-10-05 1970-03-23 Astra Ab
FR2014831A1 (en) * 1968-08-01 1970-04-24 Sogeras Quinuclidinyl and quinuclidinylalkyl ethers with cholino - lytic, antihistaminic and neurosedative activity
GB8615785D0 (en) * 1986-06-27 1986-08-06 Beecham Group Plc Compounds
ATE133415T1 (de) * 1987-04-15 1996-02-15 Beecham Group Plc Am brückenkopf substituierte azabicyclenderivate
GB8718445D0 (en) * 1987-08-04 1987-09-09 Wyeth John & Brother Ltd Pyridyl-ethers
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
DE3839385A1 (de) * 1988-11-22 1990-05-23 Boehringer Ingelheim Kg Neue quinuclidine, ihre herstellung als arzneimittel und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
HUT58091A (en) 1992-01-28
CA2042860A1 (en) 1991-11-20
JP2853837B2 (ja) 1999-02-03
CS144891A3 (en) 1992-05-13
IL98176A0 (en) 1992-06-21
KR910020009A (ko) 1991-12-19
CZ281837B6 (cs) 1997-02-12
JPH04226981A (ja) 1992-08-17
AU7713091A (en) 1991-11-21
PT97703A (pt) 1992-02-28
HU911663D0 (en) 1991-11-28
NO911934L (no) 1991-11-20
AU648789B2 (en) 1994-05-05
NO911934D0 (no) 1991-05-16
FI912409A0 (fi) 1991-05-17
YU84791A (sh) 1994-06-10
FI912409A (fi) 1991-11-20
IE911688A1 (en) 1991-11-20
EP0458214A1 (de) 1991-11-27

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