SK279144B6 - Spôsob výroby hematopoetínu il-6 - Google Patents

Spôsob výroby hematopoetínu il-6 Download PDF

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Publication number
SK279144B6
SK279144B6 SK5150-87A SK515087A SK279144B6 SK 279144 B6 SK279144 B6 SK 279144B6 SK 515087 A SK515087 A SK 515087A SK 279144 B6 SK279144 B6 SK 279144B6
Authority
SK
Slovakia
Prior art keywords
leu
ala
ser
aac
lys
Prior art date
Application number
SK5150-87A
Other languages
English (en)
Slovak (sk)
Other versions
SK515087A3 (en
Inventor
Steven C. Clark
Gordon G. Wong
Paul Schendel
John Mccoy
Original Assignee
Sandoz A.G.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27367237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK279144(B6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sandoz A.G. filed Critical Sandoz A.G.
Publication of SK515087A3 publication Critical patent/SK515087A3/sk
Publication of SK279144B6 publication Critical patent/SK279144B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5412—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/204—IL-6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/217—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Materials For Medical Uses (AREA)
SK5150-87A 1986-07-08 1987-07-07 Spôsob výroby hematopoetínu il-6 SK279144B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88320786A 1986-07-08 1986-07-08
US88590586A 1986-07-15 1986-07-15
US4795787A 1987-05-08 1987-05-08

Publications (2)

Publication Number Publication Date
SK515087A3 SK515087A3 (en) 1998-07-08
SK279144B6 true SK279144B6 (sk) 1998-07-08

Family

ID=27367237

Family Applications (1)

Application Number Title Priority Date Filing Date
SK5150-87A SK279144B6 (sk) 1986-07-08 1987-07-07 Spôsob výroby hematopoetínu il-6

Country Status (18)

Country Link
EP (2) EP0574955B1 (de)
JP (1) JP2664698B2 (de)
KR (1) KR960013601B1 (de)
AT (2) ATE124959T1 (de)
AU (1) AU615630B2 (de)
CA (1) CA1341355C (de)
DE (2) DE3751922T2 (de)
DK (1) DK173279B1 (de)
ES (1) ES2006776A6 (de)
GR (1) GR871027B (de)
IE (1) IE67035B1 (de)
IL (1) IL83137A (de)
MY (1) MY102865A (de)
NO (1) NO176665C (de)
PL (1) PL159182B1 (de)
PT (1) PT85285B (de)
SK (1) SK279144B6 (de)
WO (1) WO1988000206A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554513A (en) * 1979-11-21 1996-09-10 Yeda Research & Development Co. Ltd. Production of recombinant human interferon-beta2
US5510472A (en) * 1979-11-21 1996-04-23 Yeda Research And Development Co. Ltd. Production of recombinant human interferon-beta2
DE3688671T3 (de) * 1985-10-14 2001-05-03 Yeda Research And Development Co., Ltd. Menschliches Interferon-beta2A ; Vektoren, die Gene enthalten, die für das genannte Interferon kodieren; Zellinien, die dieses produzieren und Verwendung des genannten Interferons als Pharmazeutikum.
JP2648860B2 (ja) * 1986-05-08 1997-09-03 イエダ リサーチ アンド デベロップメント コンパニー リミテッド ヒトインターフエロン−β２Ａ及びヒトインターフエロン−β２Ｂ、該インターフエロンをコードする遺伝子を含むベクター、該インターフエロンを産生するセルライン及び該インターフエロンの医薬品としての用途
JP2676336B2 (ja) * 1986-08-06 1997-11-12 忠三 岸本 ヒトｂ細胞分化因子の遺伝子
JPS6356291A (ja) * 1986-08-27 1988-03-10 Chuzo Kishimoto リコンビナントｂｃｄｆ
EP0257406B2 (de) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Rekombinanter B-Zell-Differenzierungsfaktor
NZ226799A (en) * 1987-11-06 1991-08-27 Oncogen Breast cancer inhibitory factor and method for inhibiting proliferation of neoplastic cells and compositions therefor
IL85204A0 (en) * 1988-01-26 1988-07-31 Yeda Res & Dev Recombinant human interferon beta2,its preparation and pharmaceutical compositions comprising it
CA1341588C (en) * 1988-01-26 2009-01-06 Michel Revel Human ifn-beta2/i1-6, its purification and use
HUT52962A (en) * 1988-03-04 1990-09-28 Sandoz Ag Process for production of medical compositions eliminating bone-absorption and promoting forming of bones
JPH022353A (ja) * 1988-03-10 1990-01-08 Tosoh Corp ヒトｂ細胞分化因子の製造法
JPH022354A (ja) * 1988-03-31 1990-01-08 Tosoh Corp ヒトｂ細胞分化因子の製造法
GB2217327B (en) * 1988-04-12 1992-01-29 British Bio Technology Synthetic interleukin-6 gene
US5223407A (en) * 1988-08-31 1993-06-29 Allelix Inc. Excretion of heterologous proteins from e. coli
US5646015A (en) * 1988-08-31 1997-07-08 Astra Ab Excretion of heterologous proteins from E. coli
US5271931A (en) * 1988-09-14 1993-12-21 The Scripps Research Institute Methods for increasing C1 inhibitor concentrations using interferon-gamma and/or interleukin-6
JPH0372429A (ja) * 1988-10-07 1991-03-27 Chugai Pharmaceut Co Ltd 血小板減少症の治療剤
US5811523A (en) 1988-11-10 1998-09-22 Trinchieri; Giorgio Antibodies to natural killer stimulatory factor
JP2805224B2 (ja) * 1989-01-13 1998-09-30 味の素株式会社 血小板減少症治療剤
JPH0331215A (ja) * 1989-06-27 1991-02-12 Ajinomoto Co Inc 制癌療法支持剤
DE3939706C1 (de) * 1989-12-01 1991-03-21 Centre Regional De Transfusion Sanguine, Besancon, Fr
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
DE69122764T2 (de) * 1990-08-31 1997-03-20 Teruo Nishida Arznei gegen hornhautbeschädigungen
US5641868A (en) * 1991-04-18 1997-06-24 Toray Industries, Inc. Interlekin-6 compositions, and a production process thereof
ES2164050T3 (es) * 1991-04-18 2002-02-16 Toray Industries Preparacion de compuestos de interleuquina-6.
ZA924674B (en) * 1991-07-02 1993-04-28 Imclone Systems Inc Cysteine depleted il-6 mutein
US5338833A (en) * 1992-07-23 1994-08-16 The University Of North Carolina At Chapel Hill Carboxy terminal IL-6 muteins
US5338834A (en) * 1993-01-26 1994-08-16 Allelix Biopharmaceuticals Inc. Ultrapure human interleukin-6
WO1994028919A1 (en) * 1993-06-08 1994-12-22 Ajinomoto Co., Inc. Hematopoietic cell proliferation accelerator
US5578301A (en) * 1993-12-14 1996-11-26 Sandoz Ltd. Method for using GM-CSF to reduce the acute phase response in a patient being administered IL-6 therapy
US5599536A (en) * 1993-12-13 1997-02-04 Sandoz Ltd. Method for suppressing the acute phase response in a patient receiving IL-6 therapy
US5641657A (en) * 1994-05-19 1997-06-24 Human Genome Sciences, Inc. DNA encoding an interleukin-6 splice variant
EP0721780A3 (de) * 1994-12-16 1997-12-17 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Mittel zur Förderung von Plättchen und/oder Leucozytenherstellung
WO1998003657A1 (en) * 1996-07-19 1998-01-29 Dade Behring Marburg Gmbh Viral interleukin-6
SE9702401D0 (sv) 1997-06-19 1997-06-19 Astra Ab Pharmaceutical use
US7479540B1 (en) 2003-12-22 2009-01-20 Chandan Prasad Adipomodulin and related molecules and methods
US20090136444A1 (en) * 2005-02-15 2009-05-28 Apollo Life Sciences Limited molecule and chimeric molecules thereof
ES2302402B1 (es) * 2005-06-16 2009-05-08 Proyecto De Biomedicina Cima, S.L. Uso de una citoquina de la familia de interleuquina-6 en la preparacion de una composicion para administracion combinada con interferon-alfa.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL58765A (en) * 1979-11-21 1986-09-30 Yeda Res & Dev Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
US4675285A (en) * 1984-09-19 1987-06-23 Genetics Institute, Inc. Method for identification and isolation of DNA encoding a desired protein
DE3688671T3 (de) * 1985-10-14 2001-05-03 Yeda Research And Development Co., Ltd. Menschliches Interferon-beta2A ; Vektoren, die Gene enthalten, die für das genannte Interferon kodieren; Zellinien, die dieses produzieren und Verwendung des genannten Interferons als Pharmazeutikum.
EP0257406B2 (de) * 1986-08-06 1998-08-12 Ajinomoto Co., Inc. Rekombinanter B-Zell-Differenzierungsfaktor

Also Published As

Publication number Publication date
JP2664698B2 (ja) 1997-10-15
MY102865A (en) 1993-03-31
GR871027B (en) 1987-11-02
EP0574955A1 (de) 1993-12-22
DE3751406T2 (de) 1995-12-21
DE3751406D1 (de) 1995-08-17
JPH01503354A (ja) 1989-11-16
EP0316319B1 (de) 1995-07-12
PT85285B (pt) 1990-03-30
NO176665C (no) 1995-05-10
ATE143811T1 (de) 1996-10-15
IE67035B1 (en) 1996-02-21
EP0316319A4 (de) 1989-08-09
KR880701736A (ko) 1988-11-04
IL83137A (en) 1995-05-26
EP0316319A1 (de) 1989-05-24
NO880929D0 (no) 1988-03-02
DK121788A (da) 1988-03-07
KR960013601B1 (ko) 1996-10-09
DE3751922D1 (de) 1996-11-14
DK121788D0 (da) 1988-03-07
DE3751922T2 (de) 1997-04-03
CA1341355C (en) 2002-04-09
ATE124959T1 (de) 1995-07-15
EP0574955B1 (de) 1996-10-09
NO880929L (no) 1988-03-02
PT85285A (en) 1987-08-01
SK515087A3 (en) 1998-07-08
ES2006776A6 (es) 1989-05-16
WO1988000206A1 (en) 1988-01-14
NO176665B (no) 1995-01-30
PL159182B1 (pl) 1992-11-30
DK173279B1 (da) 2000-06-05
AU7696287A (en) 1988-01-29
IE871726L (en) 1988-01-08
PL266680A1 (en) 1988-07-07
AU615630B2 (en) 1991-10-10

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