SK278731B6 - Spôsob výroby vo vode rozpustného farmaceutického - Google Patents
Spôsob výroby vo vode rozpustného farmaceutického Download PDFInfo
- Publication number
- SK278731B6 SK278731B6 SK3490-90A SK349090A SK278731B6 SK 278731 B6 SK278731 B6 SK 278731B6 SK 349090 A SK349090 A SK 349090A SK 278731 B6 SK278731 B6 SK 278731B6
- Authority
- SK
- Slovakia
- Prior art keywords
- water
- process according
- metallocene complex
- polyol
- mixtures
- Prior art date
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 title claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 2
- 229920005862 polyol Polymers 0.000 claims abstract description 14
- 150000003077 polyols Chemical class 0.000 claims abstract description 14
- 239000000654 additive Substances 0.000 claims abstract description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract 5
- 239000000203 mixture Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 16
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
- 238000004090 dissolution Methods 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 9
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 9
- 239000000600 sorbitol Substances 0.000 claims description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 238000004108 freeze drying Methods 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- 239000006184 cosolvent Substances 0.000 claims description 5
- YXQWGVLNDXNSJJ-UHFFFAOYSA-N cyclopenta-1,3-diene;vanadium(2+) Chemical class [V+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 YXQWGVLNDXNSJJ-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
- KOMDZQSPRDYARS-UHFFFAOYSA-N cyclopenta-1,3-diene titanium Chemical compound [Ti].C1C=CC=C1.C1C=CC=C1 KOMDZQSPRDYARS-UHFFFAOYSA-N 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 239000008101 lactose Substances 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 3
- 229930195725 Mannitol Natural products 0.000 claims description 3
- 150000001720 carbohydrates Chemical class 0.000 claims description 3
- 235000014633 carbohydrates Nutrition 0.000 claims description 3
- 150000002334 glycols Chemical class 0.000 claims description 3
- 239000000594 mannitol Substances 0.000 claims description 3
- 235000010355 mannitol Nutrition 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 150000005846 sugar alcohols Chemical class 0.000 claims description 3
- ALQSHHUCVQOPAS-UHFFFAOYSA-N 1,5-Pentadiol Natural products OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- ZMMRKRFMSDTOLV-UHFFFAOYSA-N cyclopenta-1,3-diene zirconium Chemical compound [Zr].C1C=CC=C1.C1C=CC=C1 ZMMRKRFMSDTOLV-UHFFFAOYSA-N 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- 238000009210 therapy by ultrasound Methods 0.000 claims description 2
- 230000000996 additive effect Effects 0.000 claims 1
- YONPGGFAJWQGJC-UHFFFAOYSA-K titanium(iii) chloride Chemical group Cl[Ti](Cl)Cl YONPGGFAJWQGJC-UHFFFAOYSA-K 0.000 claims 1
- 239000000824 cytostatic agent Substances 0.000 abstract description 5
- 230000001085 cytostatic effect Effects 0.000 abstract description 5
- 238000002360 preparation method Methods 0.000 abstract description 4
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 23
- 239000007864 aqueous solution Substances 0.000 description 8
- MKNXBRLZBFVUPV-UHFFFAOYSA-L cyclopenta-1,3-diene;dichlorotitanium Chemical compound Cl[Ti]Cl.C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 MKNXBRLZBFVUPV-UHFFFAOYSA-L 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 239000008215 water for injection Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 150000001450 anions Chemical class 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 238000007911 parenteral administration Methods 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 229960005070 ascorbic acid Drugs 0.000 description 3
- 235000010323 ascorbic acid Nutrition 0.000 description 3
- 239000011668 ascorbic acid Substances 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- KJXKHGDHXCOQTK-UHFFFAOYSA-L cyclopenta-1,3-diene;molybdenum(4+);dichloride Chemical compound [Cl-].[Cl-].[Mo+4].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KJXKHGDHXCOQTK-UHFFFAOYSA-L 0.000 description 3
- ZSWFCLXCOIISFI-UHFFFAOYSA-N endo-cyclopentadiene Natural products C1C=CC=C1 ZSWFCLXCOIISFI-UHFFFAOYSA-N 0.000 description 3
- 238000002604 ultrasonography Methods 0.000 description 3
- 125000000058 cyclopentadienyl group Chemical group C1(=CC=CC1)* 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- RDUAXDDQRLRHQZ-UHFFFAOYSA-N 2-hydroxypropane-1,1,1-tricarboxylic acid Chemical compound CC(O)C(C(O)=O)(C(O)=O)C(O)=O RDUAXDDQRLRHQZ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 101100010166 Mus musculus Dok3 gene Proteins 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- CSEGCHWAMVIXSA-UHFFFAOYSA-L cyclopenta-1,3-diene;hafnium(4+);dichloride Chemical compound [Cl-].[Cl-].[Hf+4].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 CSEGCHWAMVIXSA-UHFFFAOYSA-L 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000001779 embryotoxic effect Effects 0.000 description 1
- 231100000238 embryotoxicity Toxicity 0.000 description 1
- 230000005496 eutectics Effects 0.000 description 1
- -1 hafnocene Chemical compound 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 239000007951 isotonicity adjuster Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000185 sucrose group Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- VPGLGRNSAYHXPY-UHFFFAOYSA-L zirconium(2+);dichloride Chemical compound Cl[Zr]Cl VPGLGRNSAYHXPY-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3923270A DE3923270A1 (de) | 1989-07-14 | 1989-07-14 | Wasserloesliche pharmazeutische metallocen-komplex-zusammensetzung |
Publications (1)
Publication Number | Publication Date |
---|---|
SK278731B6 true SK278731B6 (sk) | 1998-02-04 |
Family
ID=6385007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK3490-90A SK278731B6 (sk) | 1989-07-14 | 1990-07-13 | Spôsob výroby vo vode rozpustného farmaceutického |
Country Status (15)
Country | Link |
---|---|
US (1) | US5296237A (sv) |
EP (1) | EP0407804B1 (sv) |
JP (1) | JPH03128319A (sv) |
KR (1) | KR0165676B1 (sv) |
AT (1) | ATE96665T1 (sv) |
AU (1) | AU624006B2 (sv) |
CZ (1) | CZ279046B6 (sv) |
DD (1) | DD296417A5 (sv) |
DE (2) | DE3923270A1 (sv) |
DK (1) | DK0407804T3 (sv) |
ES (1) | ES2059899T3 (sv) |
FI (1) | FI95870C (sv) |
HU (1) | HU208073B (sv) |
IL (1) | IL94867A (sv) |
SK (1) | SK278731B6 (sv) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4135291A1 (de) * | 1991-10-25 | 1993-04-29 | Koepf Maier Petra | Cytostatisch wirksame ionische metallocen-komplexe und diese komplexe enthaltende arzneimittel |
CA2127114C (en) * | 1992-10-30 | 2003-05-13 | Gennady A. Markov | A composition for the biological stimulation and correction of the phenotype of an organism and a method for treating the same |
HU212105B (en) * | 1993-03-19 | 1996-02-28 | Nitrokemia Ipartelepek | Process for producing titanium compounds of antitumor activiti and pharmaceutical compositions containing them |
US6051603A (en) | 1998-01-20 | 2000-04-18 | Wayne Hughes Institute | Vanadium (IV) metallocene complexes having sperm motility inhibiting activity |
US6432941B1 (en) | 1998-01-20 | 2002-08-13 | Parker Hughes Institute | Vanadium compounds for treating cancer |
US6245808B1 (en) | 1998-11-05 | 2001-06-12 | Parker Hughes Institute | Oxy-vanadium (IV) complexes having spermicidal activity |
WO2000035930A1 (en) * | 1998-01-20 | 2000-06-22 | Parker Hughes Institute | Vanadium compounds for treating cancer |
JPH11214927A (ja) | 1998-01-29 | 1999-08-06 | Murata Mfg Co Ltd | 高周波モジュール |
KR20020048494A (ko) * | 2000-12-18 | 2002-06-24 | 신형인 | 내 컷팅 및 칩핑성이 향상된 고무조성물 |
RU2297877C2 (ru) * | 2001-06-13 | 2007-04-27 | Энерджи Энд Энвиронментал Интернэшнл, Л.К. | Реакторы для полимеризации в объеме и способы такой полимеризации |
RU2197499C2 (ru) * | 2001-08-23 | 2003-01-27 | Бокованов Владимир Евгеньевич | Металлоценовые производные сахаров и содержащее их средство для активации киллинга микроорганизмов, локализованных внутриклеточно |
DE10151467A1 (de) | 2001-10-18 | 2003-05-08 | Bayerische Motoren Werke Ag | Schaltgetriebe mit Verriegelungseinrichtung zur Verriegelung einzelner Gänge |
US20040052690A1 (en) * | 2002-09-12 | 2004-03-18 | Eaton Gerald B. | Polymerization reactant injection system |
DE102006053690A1 (de) * | 2006-11-13 | 2008-05-15 | Westfälische-Wilhelms Universität Münster | Anionische Cyclopentadienyl-Kohlenhydratverbindungen |
US8809562B2 (en) | 2011-06-06 | 2014-08-19 | Chevron Phillips Chemical Company Lp | Use of metallocene compounds for cancer treatment |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2923334C2 (de) * | 1979-06-08 | 1985-03-07 | Hartmut Prof. Dipl.-Chem. Dr. Köpf | Verwendung von Cyclopentadienylmetall-Acido-Komplexen bei der Krebsbekämpfung und diese Komplexe enthaltende Arzneipräparate |
US4296030A (en) * | 1980-04-09 | 1981-10-20 | American Cyanamid Company | Metal chelates of 1,4-bis(substituted-amino-5,8-dihydroxy-anthraquinones |
DE3134709A1 (de) * | 1981-09-02 | 1983-03-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Antineoplastisch wirkende titanverbindung und diese enthaltende arzneimittel |
DE3404443A1 (de) * | 1984-02-08 | 1985-08-08 | Hartmut Prof. Dr. 1000 Berlin Köpf | Metallicenium-salze und deren verwendung als cytostatica bei der krebsbekaempfung |
JPH0662407B2 (ja) * | 1984-12-25 | 1994-08-17 | 株式会社三和化学研究所 | 安定化された3―オキシゲルミルプロピオン酸ポリマーを有効成分とする免疫調整剤 |
DE3518447A1 (de) * | 1985-05-22 | 1986-11-27 | Hartmut Prof. Dr. 1000 Berlin Köpf | Titanocen-komplexe und deren verwendung als cytostatica bei der krebsbekaempfung |
JPH0665648B2 (ja) * | 1985-09-25 | 1994-08-24 | 塩野義製薬株式会社 | 白金系抗癌物質の安定な凍結真空乾燥製剤 |
JPH0269491A (ja) * | 1988-09-05 | 1990-03-08 | Sagami Chem Res Center | チタノセン(4)錯体化合物 |
-
1989
- 1989-07-14 DE DE3923270A patent/DE3923270A1/de active Granted
-
1990
- 1990-06-26 IL IL9486790A patent/IL94867A/en not_active IP Right Cessation
- 1990-06-26 DE DE90112105T patent/DE59003304D1/de not_active Expired - Fee Related
- 1990-06-26 DK DK90112105.3T patent/DK0407804T3/da active
- 1990-06-26 ES ES90112105T patent/ES2059899T3/es not_active Expired - Lifetime
- 1990-06-26 EP EP90112105A patent/EP0407804B1/de not_active Expired - Lifetime
- 1990-06-26 AT AT90112105T patent/ATE96665T1/de not_active IP Right Cessation
- 1990-06-26 AU AU57879/90A patent/AU624006B2/en not_active Ceased
- 1990-06-28 KR KR1019900009662A patent/KR0165676B1/ko not_active IP Right Cessation
- 1990-07-11 DD DD90342670A patent/DD296417A5/de not_active IP Right Cessation
- 1990-07-13 JP JP2186977A patent/JPH03128319A/ja active Pending
- 1990-07-13 HU HU904199A patent/HU208073B/hu not_active IP Right Cessation
- 1990-07-13 SK SK3490-90A patent/SK278731B6/sk unknown
- 1990-07-13 CZ CS903490A patent/CZ279046B6/cs unknown
- 1990-07-13 FI FI903573A patent/FI95870C/sv not_active IP Right Cessation
-
1991
- 1991-12-19 US US07/810,449 patent/US5296237A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR910002439A (ko) | 1991-02-25 |
DE3923270C2 (sv) | 1991-07-25 |
AU5787990A (en) | 1991-01-17 |
HUT55224A (en) | 1991-05-28 |
EP0407804A1 (de) | 1991-01-16 |
DK0407804T3 (da) | 1994-02-07 |
US5296237A (en) | 1994-03-22 |
JPH03128319A (ja) | 1991-05-31 |
FI903573A0 (sv) | 1990-07-13 |
CS349090A3 (en) | 1992-01-15 |
CZ279046B6 (en) | 1994-12-15 |
FI95870B (sv) | 1995-12-29 |
HU904199D0 (en) | 1990-12-28 |
HU208073B (en) | 1993-08-30 |
DD296417A5 (de) | 1991-12-05 |
EP0407804B1 (de) | 1993-11-03 |
AU624006B2 (en) | 1992-05-28 |
FI95870C (sv) | 1996-04-10 |
IL94867A (en) | 1995-01-24 |
DE59003304D1 (de) | 1993-12-09 |
ES2059899T3 (es) | 1994-11-16 |
DE3923270A1 (de) | 1991-01-17 |
ATE96665T1 (de) | 1993-11-15 |
KR0165676B1 (ko) | 1999-01-15 |
IL94867A0 (en) | 1991-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK278731B6 (sk) | Spôsob výroby vo vode rozpustného farmaceutického | |
JP3576180B2 (ja) | 改良イフォスファミド凍結乾燥組成物 | |
DE60132108T2 (de) | Gefriergetrocknetes pantoprazol-präparat und pantoprazol-injektion | |
JP5689816B2 (ja) | 非経口用医薬組成物及びその非経口用医薬組成物の製造方法 | |
CS270421B2 (en) | Method of anthracycline glycoside containing lyophilized agent production | |
EP1903039A1 (en) | Injection | |
JPH0257049B2 (sv) | ||
NZ200908A (en) | Salts of quinoline(and 1,8-naphthyridine)-3-carboxylic acids and antimicrobial compositions | |
KR101468153B1 (ko) | 5α-안드로스테인-3β,5,6β-트리올 주사제 및 제조방법 | |
KR950010150B1 (ko) | 니코란딜 함유 주사제의 안정화 방법 | |
RU2205012C2 (ru) | Фармацевтические композиции для сушки вымораживанием | |
CA1160571A (en) | Antitumor compositions | |
US4303582A (en) | Spray drying process for preparation of solid sodium amoxycillin | |
CA2548074A1 (en) | Injectable composition | |
HU199289B (en) | Process for production of liofilized medical compositions containing derivatives of phenil-quinoline-carbonic acid | |
EA008145B1 (ru) | Инъецируемая галеновая форма флупиртина | |
KR20210144810A (ko) | 벤조아제핀 화합물-함유 동결건조 조성물 | |
JPH0149693B2 (sv) | ||
JP2012501331A (ja) | カンフォスファミド製剤及びその製造方法 | |
US4425348A (en) | Antitumor compositions | |
EP0006223A1 (en) | Crystalline sodium and potassium indomethacin and their trihydrates, process for preparing and pharmaceutical compositions containing the same | |
CA2021268A1 (en) | Water-soluble pharmaceutical metallocene-complex composition | |
KR100315872B1 (ko) | 디히드로피리딘 유도체를 포함하는 지속성 제제의 제조방법 | |
EP0449722B1 (fr) | Nouveaux complexes de l'acide tiaprofénique ou de ses esters insolubles ou partiellement solubles avec les cyclodextrines ou leurs dérivés | |
US4626541A (en) | Water soluble salt composition of m-AMSA |