SK14762003A3 - Kožou prestupujúci prípravok obsahujúci selektívne inhibujúcu cyklooxygenázu-2 a jednosýtny alkohol - Google Patents
Kožou prestupujúci prípravok obsahujúci selektívne inhibujúcu cyklooxygenázu-2 a jednosýtny alkohol Download PDFInfo
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- SK14762003A3 SK14762003A3 SK1476-2003A SK14762003A SK14762003A3 SK 14762003 A3 SK14762003 A3 SK 14762003A3 SK 14762003 A SK14762003 A SK 14762003A SK 14762003 A3 SK14762003 A3 SK 14762003A3
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- skin
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- acid
- skin permeation
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- 239000000203 mixture Substances 0.000 title claims abstract description 275
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title claims abstract description 131
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title description 2
- 229940093444 Cyclooxygenase 2 inhibitor Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 82
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 75
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 62
- 239000000651 prodrug Substances 0.000 claims abstract description 49
- 229940002612 prodrug Drugs 0.000 claims abstract description 49
- 238000000034 method Methods 0.000 claims abstract description 47
- 206010061218 Inflammation Diseases 0.000 claims abstract description 38
- 230000004054 inflammatory process Effects 0.000 claims abstract description 38
- 208000002193 Pain Diseases 0.000 claims abstract description 35
- 230000036407 pain Effects 0.000 claims abstract description 35
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 25
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 19
- 208000035475 disorder Diseases 0.000 claims abstract description 18
- 239000003937 drug carrier Substances 0.000 claims abstract description 12
- 230000001404 mediated effect Effects 0.000 claims abstract description 12
- 238000012384 transportation and delivery Methods 0.000 claims abstract description 9
- 239000012088 reference solution Substances 0.000 claims abstract description 8
- 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 claims description 87
- 238000009472 formulation Methods 0.000 claims description 87
- 239000004480 active ingredient Substances 0.000 claims description 72
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims description 70
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- -1 vaidecoxib Chemical compound 0.000 claims description 66
- LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 claims description 60
- 229960002004 valdecoxib Drugs 0.000 claims description 58
- TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 claims description 52
- 229960004662 parecoxib Drugs 0.000 claims description 50
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 claims description 44
- 239000003961 penetration enhancing agent Substances 0.000 claims description 43
- 150000001875 compounds Chemical class 0.000 claims description 42
- 239000000499 gel Substances 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 27
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 25
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 24
- 150000003505 terpenes Chemical group 0.000 claims description 24
- 239000002904 solvent Substances 0.000 claims description 23
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- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims description 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 19
- 125000004432 carbon atom Chemical group C* 0.000 claims description 18
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- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 claims description 17
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical group CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 16
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 15
- 229940055577 oleyl alcohol Drugs 0.000 claims description 15
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 15
- 125000005907 alkyl ester group Chemical group 0.000 claims description 14
- 229960004050 aminobenzoic acid Drugs 0.000 claims description 14
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- 239000002253 acid Substances 0.000 claims description 13
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- 239000000194 fatty acid Substances 0.000 claims description 13
- 229930195729 fatty acid Natural products 0.000 claims description 13
- 239000011734 sodium Substances 0.000 claims description 13
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 12
- 150000002367 halogens Chemical class 0.000 claims description 12
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 12
- 229960004889 salicylic acid Drugs 0.000 claims description 12
- 235000007586 terpenes Nutrition 0.000 claims description 12
- 238000012360 testing method Methods 0.000 claims description 12
- YFUSUXATWLGGNN-UHFFFAOYSA-N (2-hydroxyacetyl) dodecanoate Chemical compound CCCCCCCCCCCC(=O)OC(=O)CO YFUSUXATWLGGNN-UHFFFAOYSA-N 0.000 claims description 11
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 239000002674 ointment Substances 0.000 claims description 11
- BAVONGHXFVOKBV-UHFFFAOYSA-N Carveol Chemical compound CC(=C)C1CC=C(C)C(O)C1 BAVONGHXFVOKBV-UHFFFAOYSA-N 0.000 claims description 10
- KRCZYMFUWVJCLI-UHFFFAOYSA-N Dihydrocarveol Chemical compound CC1CCC(C(C)=C)CC1O KRCZYMFUWVJCLI-UHFFFAOYSA-N 0.000 claims description 10
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 10
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 10
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 10
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 10
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 claims description 10
- AZOCECCLWFDTAP-UHFFFAOYSA-N dihydrocarvone Chemical compound CC1CCC(C(C)=C)CC1=O AZOCECCLWFDTAP-UHFFFAOYSA-N 0.000 claims description 10
- 229940068939 glyceryl monolaurate Drugs 0.000 claims description 10
- ZYTMANIQRDEHIO-KXUCPTDWSA-N isopulegol Chemical compound C[C@@H]1CC[C@@H](C(C)=C)[C@H](O)C1 ZYTMANIQRDEHIO-KXUCPTDWSA-N 0.000 claims description 10
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims description 10
- 239000000443 aerosol Substances 0.000 claims description 9
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- 150000002148 esters Chemical class 0.000 claims description 9
- 229960004945 etoricoxib Drugs 0.000 claims description 9
- MNJVRJDLRVPLFE-UHFFFAOYSA-N etoricoxib Chemical compound C1=NC(C)=CC=C1C1=NC=C(Cl)C=C1C1=CC=C(S(C)(=O)=O)C=C1 MNJVRJDLRVPLFE-UHFFFAOYSA-N 0.000 claims description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 229960000371 rofecoxib Drugs 0.000 claims description 9
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims description 9
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 8
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 8
- 229940041616 menthol Drugs 0.000 claims description 8
- 229960001047 methyl salicylate Drugs 0.000 claims description 8
- 239000006072 paste Substances 0.000 claims description 8
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 7
- 230000002500 effect on skin Effects 0.000 claims description 7
- 150000004665 fatty acids Chemical class 0.000 claims description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 230000003381 solubilizing effect Effects 0.000 claims description 7
- DRAWQKGUORNASA-UHFFFAOYSA-N (2-hydroxy-3-octadec-9-enoyloxypropyl) octadec-9-enoate Chemical compound CCCCCCCCC=CCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCC=CCCCCCCCC DRAWQKGUORNASA-UHFFFAOYSA-N 0.000 claims description 6
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- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims description 6
- YDIYEOMDOWUDTJ-UHFFFAOYSA-N 4-(dimethylamino)benzoic acid Chemical compound CN(C)C1=CC=C(C(O)=O)C=C1 YDIYEOMDOWUDTJ-UHFFFAOYSA-N 0.000 claims description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 6
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 claims description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
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- 235000013985 cinnamic acid Nutrition 0.000 claims description 6
- 229960001760 dimethyl sulfoxide Drugs 0.000 claims description 6
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 claims description 6
- 125000005843 halogen group Chemical group 0.000 claims description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 claims description 6
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims description 6
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- 238000007920 subcutaneous administration Methods 0.000 claims description 6
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- AMEMLELAMQEAIA-UHFFFAOYSA-N 6-(tert-butyl)thieno[3,2-d]pyrimidin-4(3H)-one Chemical compound N1C=NC(=O)C2=C1C=C(C(C)(C)C)S2 AMEMLELAMQEAIA-UHFFFAOYSA-N 0.000 claims description 5
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
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- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29483801P | 2001-05-31 | 2001-05-31 | |
US35075601P | 2001-11-13 | 2001-11-13 | |
PCT/US2002/017067 WO2002096435A2 (en) | 2001-05-31 | 2002-05-30 | Skin-permeable composition comprising a selective cyclooxygenase-2 inhibitor a monohydric alcohol |
Publications (1)
Publication Number | Publication Date |
---|---|
SK14762003A3 true SK14762003A3 (sk) | 2004-08-03 |
Family
ID=26968778
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1476-2003A SK14762003A3 (sk) | 2001-05-31 | 2002-05-30 | Kožou prestupujúci prípravok obsahujúci selektívne inhibujúcu cyklooxygenázu-2 a jednosýtny alkohol |
Country Status (25)
Country | Link |
---|---|
US (1) | US20030161867A1 (cs) |
EP (1) | EP1404345A2 (cs) |
JP (1) | JP2004532871A (cs) |
KR (1) | KR20040033286A (cs) |
CN (1) | CN1547474A (cs) |
AP (1) | AP2003002922A0 (cs) |
BR (1) | BR0210104A (cs) |
CA (1) | CA2448627A1 (cs) |
CO (1) | CO5640125A2 (cs) |
CR (1) | CR7173A (cs) |
CZ (1) | CZ20033241A3 (cs) |
EA (1) | EA200301200A1 (cs) |
EC (1) | ECSP034869A (cs) |
HU (1) | HUP0600294A2 (cs) |
IL (1) | IL159100A0 (cs) |
IS (1) | IS7055A (cs) |
MA (1) | MA27030A1 (cs) |
MX (1) | MXPA03010991A (cs) |
NO (1) | NO20035325D0 (cs) |
OA (1) | OA12613A (cs) |
PL (1) | PL367337A1 (cs) |
SK (1) | SK14762003A3 (cs) |
TN (1) | TNSN03127A1 (cs) |
WO (1) | WO2002096435A2 (cs) |
ZA (1) | ZA200309298B (cs) |
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US20040127531A1 (en) * | 2002-11-21 | 2004-07-01 | Lu Guang Wei | Adhesive coated sheet for dermal delivery of a selective cyclooxygenase-2 inhibitor |
US20040126415A1 (en) * | 2002-11-21 | 2004-07-01 | Lu Guang Wei | Dermal delivery of a water-soluble selective cyclooxygenase-2 inhibitor |
US20050020658A1 (en) * | 2002-11-21 | 2005-01-27 | Katsuyuki Inoo | Selective cyclooxygenase-2 inhibitor patch |
AU2004206783B2 (en) * | 2003-01-23 | 2009-03-26 | Shire Holdings Ag | Formulation and methods for the treatment of thrombocythemia |
JP2007508263A (ja) * | 2003-10-08 | 2007-04-05 | ノバルティス アクチエンゲゼルシャフト | 5−メチル−2−(2’−クロロ−6’−フルオロアニリノ)フェニル酢酸を含む薬学的組成物 |
WO2005044227A1 (en) * | 2003-11-05 | 2005-05-19 | Glenmark Pharmaceuticals Limited | Topical pharmaceutical compositions |
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EP1835884A2 (en) * | 2005-01-14 | 2007-09-26 | Lipo Chemicals Inc | Composition and method for treating hyperpigmented skin |
US20060229347A1 (en) * | 2005-03-30 | 2006-10-12 | Astion Development A/S | Treatment of eczemas |
RS50693B (sr) * | 2005-06-14 | 2010-06-30 | Uni-Pharma Kleon Tsetis Pharmaceutical | Stabilni farmaceutski gel diklofenak natrijuma |
US20070243275A1 (en) * | 2006-04-13 | 2007-10-18 | Gilbard Jeffrey P | Methods and compositions for the treatment of infection or infectious colonization of the eyelid, ocular surface, skin or ear |
US20120040809A1 (en) | 2010-08-11 | 2012-02-16 | Formicola Thomas M | Stretch-Out Roll Up Bar |
FR2905601A1 (fr) * | 2006-09-11 | 2008-03-14 | Innoderm Sarl | Utilisation de derives oleiques comme methode et composition favorisant la penetration cutanee des actifs contenus dans les compositions cosmetiques, pharmaceutiques ou dermatologiques. |
AU2007311019B2 (en) | 2006-10-17 | 2013-05-16 | Nuvo Pharmaceuticals, Inc | Diclofenac gel |
US7910597B2 (en) | 2006-11-28 | 2011-03-22 | Shire Llc | Substituted quinazolines |
US8304420B2 (en) | 2006-11-28 | 2012-11-06 | Shire Llc | Substituted quinazolines for reducing platelet count |
HU227970B1 (en) * | 2007-07-10 | 2012-07-30 | Egis Gyogyszergyar Nyrt | Pharmaceutical compositions containing silicones of high volatility |
DE102007034976A1 (de) | 2007-07-26 | 2009-01-29 | Bayer Healthcare Ag | Arzneimittel zur transdermalen Anwendung bei Tieren |
US9050293B2 (en) | 2008-07-16 | 2015-06-09 | Juventio, Llc | Small molecule solubilization system |
CN102186341B (zh) | 2008-10-20 | 2013-12-25 | 荷兰联合利华有限公司 | 抗菌组合物 |
US8618164B2 (en) | 2009-03-31 | 2013-12-31 | Nuvo Research Inc. | Treatment of pain with topical diclofenac compounds |
PT2424374T (pt) | 2009-05-01 | 2018-04-23 | Advanced Vision Res Inc | Composições de limpeza e métodos para utilização das mesmas |
EP2480090B1 (en) | 2009-09-24 | 2013-11-06 | Unilever NV | Disinfecting agent comprising eugenol, terpineol and thymol |
EP2482850A2 (en) * | 2009-09-30 | 2012-08-08 | Nuvo Research Inc. | Topical formulations |
WO2011044540A1 (en) | 2009-10-09 | 2011-04-14 | Nuvo Research Inc. | Topical formulation comprising etoricoxib and a zwitterionic surfactant |
WO2011149645A1 (en) * | 2010-05-28 | 2011-12-01 | Nuvo Research Inc. | Topical etoricoxib formulation |
EA201201632A1 (ru) * | 2010-05-31 | 2013-04-30 | Юнилевер Н.В. | Композиция для ухода за кожей |
JP2012020991A (ja) * | 2010-06-16 | 2012-02-02 | Takasago Internatl Corp | 経皮吸収促進剤、及びこれを含有する皮膚外用製剤 |
MX2013006435A (es) | 2010-12-07 | 2013-07-03 | Unilever Nv | Composicion para cuidado oral. |
EP2736491B1 (en) | 2011-01-04 | 2017-04-05 | Bausch & Lomb Incorporated | Bepotastine compositions |
EP2691076A1 (en) * | 2011-03-31 | 2014-02-05 | Evocutis plc | Usnic acid topical formulation |
AU2012320166A1 (en) * | 2011-10-05 | 2014-05-01 | Douglas Pharmaceuticals Ltd. | Pharmaceutical methods and topical compositions containing acitretin |
EA024551B1 (ru) | 2011-11-03 | 2016-09-30 | Юнилевер Н.В. | Индивидуальная композиция для очищения |
GB201205642D0 (en) | 2012-03-29 | 2012-05-16 | Sequessome Technology Holdings Ltd | Vesicular formulations |
GB201206486D0 (en) * | 2012-04-12 | 2012-05-30 | Sequessome Technology Holdings Ltd | Vesicular formulations and uses thereof |
US10045965B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
US10045935B2 (en) | 2012-07-31 | 2018-08-14 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
US11154535B2 (en) | 2012-07-31 | 2021-10-26 | Egis Pharmaceuticals Plc | Transdermal formulation containing COX inhibitors |
ES2686675T3 (es) * | 2013-03-29 | 2018-10-19 | Askat Inc. | Agente terapéutico para enfermedad ocular |
CA2932156A1 (en) * | 2013-12-24 | 2015-07-02 | The Procter & Gamble Company | Cosmetic compositions and methods providing enhanced penetration of skin care actives |
DK3218060T3 (da) * | 2014-11-10 | 2019-12-02 | Achelios Therapeutics Inc | Spraybare analgetiske sammensætninger |
LT3316857T (lt) | 2015-06-30 | 2021-11-25 | Sequessome Technology Holdings Limited | Daugiafazės kompozicijos |
CN105663032A (zh) * | 2016-02-23 | 2016-06-15 | 青岛科技大学 | 一种维他昔布软膏剂的制备方法 |
CN106267218A (zh) * | 2016-10-18 | 2017-01-04 | 华北理工大学 | 4‑萜品醇脂肪酸酯衍生物及其应用和制备方法 |
KR102042456B1 (ko) * | 2018-03-22 | 2019-11-08 | 크리스탈지노믹스(주) | 경피흡수제제 |
KR20210028609A (ko) * | 2018-05-31 | 2021-03-12 | 고쿠리쓰다이가쿠호진 규슈다이가쿠 | 경피 흡수성 제제 |
RU2685436C1 (ru) * | 2018-06-22 | 2019-04-18 | ЗАО "ФармФирма "Сотекс" | Трансдермальный препарат для лечения и профилактики болезней суставов и мягких тканей |
KR20220001170A (ko) | 2020-06-29 | 2022-01-05 | 김종림 | 앙카볼트 |
KR102619716B1 (ko) * | 2020-10-20 | 2023-12-29 | 고려대학교 산학협력단 | 저온에서도 우수한 항균활성을 갖는 항진균용 조성물 |
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JP3526887B2 (ja) * | 1993-04-23 | 2004-05-17 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
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WO2000072883A2 (en) * | 1999-06-02 | 2000-12-07 | Aviana Biopharm | Pharmaceutical transdermal compositions |
IN191512B (cs) * | 2000-01-21 | 2003-12-06 | Panacea Biotech | |
JP2004503588A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 全身性疼痛および頭痛に対する選択的シクロオキシゲナーゼ−2阻害薬および血管調節化合物 |
IN191090B (cs) * | 2000-08-29 | 2003-09-20 | Ranbanx Lab Ltd | |
US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
-
2002
- 2002-05-30 IL IL15910002A patent/IL159100A0/xx unknown
- 2002-05-30 WO PCT/US2002/017067 patent/WO2002096435A2/en not_active Application Discontinuation
- 2002-05-30 OA OA1200300310A patent/OA12613A/en unknown
- 2002-05-30 JP JP2002592944A patent/JP2004532871A/ja not_active Withdrawn
- 2002-05-30 AP APAP/P/2003/002922A patent/AP2003002922A0/en unknown
- 2002-05-30 KR KR10-2003-7015581A patent/KR20040033286A/ko not_active Application Discontinuation
- 2002-05-30 HU HU0600294A patent/HUP0600294A2/hu unknown
- 2002-05-30 SK SK1476-2003A patent/SK14762003A3/sk unknown
- 2002-05-30 CZ CZ20033241A patent/CZ20033241A3/cs unknown
- 2002-05-30 PL PL02367337A patent/PL367337A1/xx not_active Application Discontinuation
- 2002-05-30 CA CA002448627A patent/CA2448627A1/en not_active Abandoned
- 2002-05-30 CN CNA028149467A patent/CN1547474A/zh active Pending
- 2002-05-30 US US10/158,342 patent/US20030161867A1/en not_active Abandoned
- 2002-05-30 EP EP02774123A patent/EP1404345A2/en not_active Withdrawn
- 2002-05-30 BR BR0210104-1A patent/BR0210104A/pt not_active IP Right Cessation
- 2002-05-30 TN TNPCT/US2002/017067A patent/TNSN03127A1/fr unknown
- 2002-05-30 EA EA200301200A patent/EA200301200A1/ru unknown
- 2002-05-30 MX MXPA03010991A patent/MXPA03010991A/es unknown
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2003
- 2003-11-27 IS IS7055A patent/IS7055A/is unknown
- 2003-11-28 MA MA27417A patent/MA27030A1/fr unknown
- 2003-11-28 ZA ZA200309298A patent/ZA200309298B/xx unknown
- 2003-11-28 CO CO03105192A patent/CO5640125A2/es not_active Application Discontinuation
- 2003-11-28 NO NO20035325A patent/NO20035325D0/no not_active Application Discontinuation
- 2003-11-28 CR CR7173A patent/CR7173A/es not_active Application Discontinuation
- 2003-11-28 EC EC2003004869A patent/ECSP034869A/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20030161867A1 (en) | 2003-08-28 |
CO5640125A2 (es) | 2006-05-31 |
EP1404345A2 (en) | 2004-04-07 |
CA2448627A1 (en) | 2002-12-05 |
WO2002096435A3 (en) | 2003-05-01 |
HUP0600294A2 (en) | 2007-02-28 |
CN1547474A (zh) | 2004-11-17 |
MA27030A1 (fr) | 2004-12-20 |
WO2002096435A2 (en) | 2002-12-05 |
EA200301200A1 (ru) | 2004-06-24 |
CZ20033241A3 (cs) | 2004-08-18 |
TNSN03127A1 (fr) | 2005-12-23 |
BR0210104A (pt) | 2004-06-08 |
IL159100A0 (en) | 2004-05-12 |
JP2004532871A (ja) | 2004-10-28 |
CR7173A (es) | 2004-04-22 |
AP2003002922A0 (en) | 2003-12-31 |
ZA200309298B (en) | 2004-05-12 |
PL367337A1 (en) | 2005-02-21 |
MXPA03010991A (es) | 2004-02-27 |
NO20035325D0 (no) | 2003-11-28 |
IS7055A (is) | 2003-11-27 |
OA12613A (en) | 2006-06-09 |
KR20040033286A (ko) | 2004-04-21 |
ECSP034869A (es) | 2004-07-23 |
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