SK13312001A3 - Spôsob prípravy stabilnej nehygroskopickej soli L(-)-karnitínu, granulát alebo prášok s obsahom kyslého fumarátu L(-)-karnitínu - Google Patents
Spôsob prípravy stabilnej nehygroskopickej soli L(-)-karnitínu, granulát alebo prášok s obsahom kyslého fumarátu L(-)-karnitínu Download PDFInfo
- Publication number
- SK13312001A3 SK13312001A3 SK1331-2001A SK13312001A SK13312001A3 SK 13312001 A3 SK13312001 A3 SK 13312001A3 SK 13312001 A SK13312001 A SK 13312001A SK 13312001 A3 SK13312001 A3 SK 13312001A3
- Authority
- SK
- Slovakia
- Prior art keywords
- carnitine
- granulate
- powder
- mass
- weight
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT1999MI000551A IT1312018B1 (it) | 1999-03-19 | 1999-03-19 | Procedimento migliorato per la produzione di sali non igroscopicidella l(-)-carnitina. |
PCT/EP2000/002344 WO2000056701A1 (en) | 1999-03-19 | 2000-03-16 | An improved process for the preparation of non-hygroscopic salts of l(-)-carnitine |
Publications (1)
Publication Number | Publication Date |
---|---|
SK13312001A3 true SK13312001A3 (sk) | 2002-05-09 |
Family
ID=11382333
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1331-2001A SK13312001A3 (sk) | 1999-03-19 | 2000-03-16 | Spôsob prípravy stabilnej nehygroskopickej soli L(-)-karnitínu, granulát alebo prášok s obsahom kyslého fumarátu L(-)-karnitínu |
Country Status (22)
Country | Link |
---|---|
US (1) | US6372940B1 (sl) |
EP (1) | EP1163207B1 (sl) |
JP (1) | JP2002540094A (sl) |
KR (1) | KR100664560B1 (sl) |
CN (1) | CN1147462C (sl) |
AR (1) | AR023101A1 (sl) |
AT (1) | ATE247627T1 (sl) |
AU (1) | AU4105800A (sl) |
CA (1) | CA2359106A1 (sl) |
CZ (1) | CZ299312B6 (sl) |
DE (1) | DE60004649T2 (sl) |
DK (1) | DK1163207T3 (sl) |
ES (1) | ES2204555T3 (sl) |
HK (1) | HK1042468A1 (sl) |
HU (1) | HUP0200402A3 (sl) |
IT (1) | IT1312018B1 (sl) |
NZ (1) | NZ512640A (sl) |
PL (1) | PL199614B1 (sl) |
PT (1) | PT1163207E (sl) |
SI (1) | SI1163207T1 (sl) |
SK (1) | SK13312001A3 (sl) |
WO (1) | WO2000056701A1 (sl) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2631569B1 (fr) * | 1988-05-20 | 1990-07-27 | Renault Automation | Detecteur de proximite magnetique destine notamment a la decoupe laser |
ITRM20010030A1 (it) * | 2001-01-23 | 2002-07-23 | Aldo Fassi | Sali di carnitine utili come integratori dietetici/nutrizionali o come farmaci, composizioni che li contengono e procedimenti per la loro pr |
SI1368349T1 (sl) * | 2001-02-24 | 2007-06-30 | Boehringer Ingelheim Pharma | Ksantinski derivati, njihova priprava in njihova uporaba kot zdravila |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
CA2810295C (en) | 2006-05-04 | 2017-11-14 | Boehringer Ingelheim International Gmbh | A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
CN101209975B (zh) * | 2006-12-29 | 2010-12-01 | 沈阳科硕营养科技有限公司 | 左旋肉碱富马酸钙及其制备方法与用途 |
KR101610005B1 (ko) * | 2007-08-17 | 2016-04-08 | 베링거 인겔하임 인터내셔날 게엠베하 | Fab 관련 질환의 치료에 사용하기 위한 푸린 유도체 |
PE20140960A1 (es) * | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
KR20200118243A (ko) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR101657960B1 (ko) * | 2008-08-15 | 2016-09-20 | 베링거 인겔하임 인터내셔날 게엠베하 | Fab-관련 질환의 치료에 사용하기 위한 푸린 유도체 |
EP2344195A2 (en) | 2008-09-10 | 2011-07-20 | Boehringer Ingelheim International GmbH | Combination therapy for the treatment of diabetes and related conditions |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
AU2009331471B2 (en) | 2008-12-23 | 2015-09-03 | Boehringer Ingelheim International Gmbh | Salt forms of organic compound |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
CA2782179C (en) | 2009-11-27 | 2020-06-23 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin |
ES2935300T3 (es) | 2010-05-05 | 2023-03-03 | Boehringer Ingelheim Int | Combiterapia |
ES2953123T3 (es) | 2010-06-24 | 2023-11-08 | Boehringer Ingelheim Int | Terapia para la diabetes |
EP2425834A1 (en) * | 2010-09-06 | 2012-03-07 | Lonza Ltd. | Process for the production of l-carnitine tartrate |
JP2012092036A (ja) * | 2010-10-26 | 2012-05-17 | Mitsubishi Rayon Co Ltd | カルニチンの塩の製造方法 |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
EP2731947B1 (en) | 2011-07-15 | 2019-01-16 | Boehringer Ingelheim International GmbH | Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
US20140316156A1 (en) * | 2013-04-18 | 2014-10-23 | Deborah Warner | Method of producing therapeutic agent |
US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
BR112018072401A2 (pt) | 2016-06-10 | 2019-02-19 | Boehringer Ingelheim International Gmbh | combinações de linagliptina e metformina |
CN106748845B (zh) * | 2016-12-23 | 2018-11-20 | 东北制药集团股份有限公司 | 一种左旋肉碱盐微粉的制备方法 |
KR20190017310A (ko) | 2017-08-10 | 2019-02-20 | 주식회사 셀트리온화학연구소 | 약제학적 성질이 개선된 l-카르니틴 화합물의 염, 이의 제조방법, 이를 함유하는 약학 조성물 |
JP6964876B2 (ja) * | 2017-11-27 | 2021-11-10 | 株式会社古川リサーチオフィス | オロット酸−カルニチン混合体粉体又はフマル酸−カルニチン混合体粉体の製造方法 |
CN108383741A (zh) * | 2018-03-16 | 2018-08-10 | 开原亨泰化工有限公司 | 一种制备左旋肉碱成盐的新方法 |
CN109096129B (zh) * | 2018-09-30 | 2021-04-27 | 东北制药集团股份有限公司 | 一种左旋肉碱酒石酸盐的制备方法 |
CN109535022B (zh) * | 2018-11-12 | 2022-03-01 | 天津大学 | 一种提高左旋肉碱富马酸盐流动性的制备方法 |
US20240217920A1 (en) * | 2022-12-28 | 2024-07-04 | Hubei Xujie Pharmaceutical Co., Ltd. | Process for producing l-carnitine |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3463261D1 (en) * | 1983-12-28 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same |
US5073376A (en) * | 1989-12-22 | 1991-12-17 | Lonza Ltd. | Preparations containing l-carnitine |
IT1289974B1 (it) | 1997-02-25 | 1998-10-19 | Aldo Fassi | Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine |
IL127266A (en) * | 1996-05-31 | 2002-09-12 | Sigma Tau Ind Farmaceuti | Stable, non-hygroscopic mucate salts of l(-) carnitine and alkanoyl l(-) carnitines, a process for their preparation and solid, orally administrable compositions containing such salts |
-
1999
- 1999-03-19 IT IT1999MI000551A patent/IT1312018B1/it active
-
2000
- 2000-03-16 SK SK1331-2001A patent/SK13312001A3/sk unknown
- 2000-03-16 DK DK00920506T patent/DK1163207T3/da active
- 2000-03-16 ES ES00920506T patent/ES2204555T3/es not_active Expired - Lifetime
- 2000-03-16 DE DE60004649T patent/DE60004649T2/de not_active Expired - Lifetime
- 2000-03-16 CA CA002359106A patent/CA2359106A1/en not_active Abandoned
- 2000-03-16 SI SI200030176T patent/SI1163207T1/sl unknown
- 2000-03-16 AT AT00920506T patent/ATE247627T1/de not_active IP Right Cessation
- 2000-03-16 JP JP2000606564A patent/JP2002540094A/ja not_active Ceased
- 2000-03-16 AU AU41058/00A patent/AU4105800A/en not_active Abandoned
- 2000-03-16 CN CNB008034001A patent/CN1147462C/zh not_active Expired - Fee Related
- 2000-03-16 NZ NZ512640A patent/NZ512640A/xx unknown
- 2000-03-16 WO PCT/EP2000/002344 patent/WO2000056701A1/en active IP Right Grant
- 2000-03-16 CZ CZ20013376A patent/CZ299312B6/cs not_active IP Right Cessation
- 2000-03-16 EP EP00920506A patent/EP1163207B1/en not_active Expired - Lifetime
- 2000-03-16 HU HU0200402A patent/HUP0200402A3/hu unknown
- 2000-03-16 US US09/868,980 patent/US6372940B1/en not_active Expired - Fee Related
- 2000-03-16 PL PL349894A patent/PL199614B1/pl not_active IP Right Cessation
- 2000-03-16 KR KR1020017010602A patent/KR100664560B1/ko not_active IP Right Cessation
- 2000-03-16 PT PT00920506T patent/PT1163207E/pt unknown
- 2000-03-17 AR ARP000101222A patent/AR023101A1/es unknown
-
2002
- 2002-05-31 HK HK02104080.1A patent/HK1042468A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ATE247627T1 (de) | 2003-09-15 |
SI1163207T1 (sl) | 2003-12-31 |
CN1339023A (zh) | 2002-03-06 |
KR20010102288A (ko) | 2001-11-15 |
HK1042468A1 (zh) | 2002-08-16 |
KR100664560B1 (ko) | 2007-01-03 |
EP1163207A1 (en) | 2001-12-19 |
PL199614B1 (pl) | 2008-10-31 |
AU4105800A (en) | 2000-10-09 |
PL349894A1 (en) | 2002-09-23 |
DK1163207T3 (da) | 2003-12-01 |
CZ299312B6 (cs) | 2008-06-18 |
IT1312018B1 (it) | 2002-04-04 |
JP2002540094A (ja) | 2002-11-26 |
HUP0200402A2 (hu) | 2002-05-29 |
CA2359106A1 (en) | 2000-09-28 |
DE60004649D1 (de) | 2003-09-25 |
DE60004649T2 (de) | 2004-03-18 |
EP1163207B1 (en) | 2003-08-20 |
PT1163207E (pt) | 2003-12-31 |
ES2204555T3 (es) | 2004-05-01 |
NZ512640A (en) | 2003-03-28 |
CN1147462C (zh) | 2004-04-28 |
WO2000056701A1 (en) | 2000-09-28 |
CZ20013376A3 (cs) | 2002-02-13 |
AR023101A1 (es) | 2002-09-04 |
ITMI990551A1 (it) | 2000-09-19 |
HUP0200402A3 (en) | 2002-11-28 |
US6372940B1 (en) | 2002-04-16 |
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