SK10202000A3 - Koryneformn baktrie produkujce l-lyzn a spsob vroby lyznu - Google Patents

Koryneformn baktrie produkujce l-lyzn a spsob vroby lyznu Download PDF

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Publication number
SK10202000A3
SK10202000A3 SK1020-2000A SK10202000A SK10202000A3 SK 10202000 A3 SK10202000 A3 SK 10202000A3 SK 10202000 A SK10202000 A SK 10202000A SK 10202000 A3 SK10202000 A3 SK 10202000A3
Authority
SK
Slovakia
Prior art keywords
gene
dapa
lysine
dapb
amplified
Prior art date
Application number
SK1020-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Caroline Kreutzer
Bettina M�Ckel
Walter Pfefferle
Lothar Eggeling
Hermann Sahm
Miroslav Patek
Original Assignee
Degussa-h�ls aktiengesellschaft
Forschungszentrum J�Lich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa-h�ls aktiengesellschaft, Forschungszentrum J�Lich Gmbh filed Critical Degussa-h�ls aktiengesellschaft
Publication of SK10202000A3 publication Critical patent/SK10202000A3/sk

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/08Lysine; Diaminopimelic acid; Threonine; Valine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK1020-2000A 1999-07-07 2000-07-04 Koryneformn baktrie produkujce l-lyzn a spsob vroby lyznu SK10202000A3 (sk)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19931314A DE19931314A1 (de) 1999-07-07 1999-07-07 L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin

Publications (1)

Publication Number Publication Date
SK10202000A3 true SK10202000A3 (sk) 2001-09-11

Family

ID=7913923

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1020-2000A SK10202000A3 (sk) 1999-07-07 2000-07-04 Koryneformn baktrie produkujce l-lyzn a spsob vroby lyznu

Country Status (15)

Country Link
EP (2) EP1619252B1 (pt)
JP (1) JP2001037495A (pt)
KR (1) KR100782867B1 (pt)
CN (2) CN100451104C (pt)
AT (2) ATE307210T1 (pt)
AU (1) AU3938600A (pt)
BR (1) BR0002445A (pt)
CA (1) CA2310890A1 (pt)
DE (3) DE19931314A1 (pt)
ES (1) ES2247987T3 (pt)
HU (1) HUP0002584A2 (pt)
ID (1) ID26461A (pt)
MX (1) MXPA00006491A (pt)
SK (1) SK10202000A3 (pt)
ZA (1) ZA200003401B (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10021829A1 (de) * 2000-05-04 2001-11-08 Degussa Neue für das pgsA2-Gen kodierende Nukleotidsequenzen
JP4120364B2 (ja) 2002-11-20 2008-07-16 味の素株式会社 メタノール資化性菌を用いたl−リジンまたはl−アルギニンの製造法
DE10344739A1 (de) * 2003-09-26 2005-04-14 Degussa Ag Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
RU2316588C1 (ru) 2004-01-30 2008-02-10 Адзиномото Ко., Инк. Бактерия - продуцент l-аминокислоты и способ получения l-аминокислоты (варианты)
CN101573438B (zh) 2006-09-15 2013-01-02 Cj第一制糖株式会社 具有增加的l-赖氨酸生产力的棒状杆菌和使用其生产l-赖氨酸的方法
KR100789274B1 (ko) * 2007-01-15 2008-01-02 씨제이 주식회사 코리네박테리움 글루타미쿰에서 유래한 신규한 프로모터핵산 분자, 그 프로모터를 포함하는 재조합 벡터, 그재조합 벡터를 포함하는 숙주 세포 및 그 숙주 세포를이용하여 유전자를 발현하는 방법
KR100830826B1 (ko) 2007-01-24 2008-05-19 씨제이제일제당 (주) 코리네박테리아를 이용하여 글리세롤을 포함한탄소원으로부터 발효산물을 생산하는 방법
JP2010088301A (ja) 2007-02-01 2010-04-22 Ajinomoto Co Inc L−アミノ酸の製造法
US8932861B2 (en) 2008-04-10 2015-01-13 Cj Cheiljedang Corporation Transformation vector comprising transposon, microorganisms transformed with the vector, and method for producing L-lysine using the microorganism
KR101126041B1 (ko) 2008-04-10 2012-03-19 씨제이제일제당 (주) 트랜스포존을 이용한 형질전환용 벡터, 상기 벡터로형질전환된 미생물 및 이를 이용한 l-라이신 생산방법
DE102010019059A1 (de) * 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
EP2582815B1 (en) * 2010-06-15 2016-08-10 Daesang Corp. Production process for amino acids of the aspartate family using microorganisms
CN102318739B (zh) * 2011-06-08 2012-08-15 宁夏伊品生物科技股份有限公司 赖氨酸的三级发酵及其包被制品
CN103215286B (zh) * 2012-11-12 2015-11-25 江南大学 用于发酵生产l-赖氨酸的重组dna、菌株及其应用
CN106635944A (zh) * 2016-12-29 2017-05-10 廊坊梅花生物技术开发有限公司 一种谷氨酸棒杆菌及其构建方法与应用
DE102017004751A1 (de) 2017-05-18 2018-11-22 Forschungszentrum Jülich GmbH Pyruvatcarboxylase und für die Pyruvatcarboxylase kodierende DNA, Plasmid enthaltend die DNA, sowie Mikroorganismus zur Produktion und verfahren zur Herstellung von Produkten, deren Bioynthese Oxalacetat als Vorstufe beeinhaltet und Chromosom
JP2022500024A (ja) 2018-09-07 2022-01-04 アーチャー−ダニエルズ−ミッドランド カンパニー エンジニアリングされたコリネバクテリア(Corynebacteria)株
CN110218749B (zh) * 2019-05-16 2023-05-12 内蒙古伊品生物科技有限公司 用改变NCgl1859的细菌发酵生产赖氨酸的方法
CA3139124C (en) * 2019-06-21 2023-01-31 Inscripta, Inc. Genome-wide rationally-designed mutations leading to enhanced lysine production in e. coli
CN111850010B (zh) * 2020-06-08 2021-04-09 黑龙江伊品生物科技有限公司 一种dapB基因改造的重组菌株及其构建方法与应用
CN115449519B (zh) * 2021-06-08 2023-04-07 中国科学院天津工业生物技术研究所 基于dapB基因的具有启动子活性的多核苷酸及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3943117A1 (de) * 1989-12-27 1991-07-04 Forschungszentrum Juelich Gmbh Verfahren zur fermentativen herstellung von aminosaeure, insbesondere l-lysin, dafuer geeignete mikroorganismen und rekombinante dna
EP0723011B1 (en) * 1993-08-24 2002-07-03 Ajinomoto Co., Inc. Variant phosphoenolpyruvate carboxylase, gene thereof, and process for producing amino acid
US20020086370A1 (en) * 1995-06-07 2002-07-04 Seiko Otsuna Method of producing l-lysine
DE19548222A1 (de) * 1995-12-22 1997-06-26 Forschungszentrum Juelich Gmbh Verfahren zur mikrobiellen Herstellung von Aminosäuren durch gesteigerte Aktivität von Exportcarriern
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
DE19831609B4 (de) * 1997-10-04 2009-11-12 Evonik Degussa Gmbh Verfahren zur Herstellung von Aminosäuren der Aspartat- und/oder Glutamatfamilie und im Verfahren einsetzbare Mittel

Also Published As

Publication number Publication date
EP1067193B1 (de) 2005-10-19
BR0002445A (pt) 2001-05-08
DE50014448D1 (de) 2007-08-09
KR100782867B1 (ko) 2007-12-06
ATE365806T1 (de) 2007-07-15
DE19931314A1 (de) 2001-01-11
EP1067193A1 (de) 2001-01-10
CA2310890A1 (en) 2001-01-07
CN1231574C (zh) 2005-12-14
CN100451104C (zh) 2009-01-14
EP1067193B8 (de) 2006-02-01
ZA200003401B (en) 2001-02-02
CN1280185A (zh) 2001-01-17
AU3938600A (en) 2001-04-12
ATE307210T1 (de) 2005-11-15
JP2001037495A (ja) 2001-02-13
KR20010049728A (ko) 2001-06-15
MXPA00006491A (es) 2002-06-04
EP1619252A1 (de) 2006-01-25
EP1619252B1 (de) 2007-06-27
ID26461A (id) 2001-01-11
ES2247987T3 (es) 2006-03-16
CN1847389A (zh) 2006-10-18
DE50011356D1 (de) 2006-03-02
HUP0002584A2 (en) 2002-09-28
HU0002584D0 (en) 2000-09-28

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