SK101798A3 - Methods for retreatment of patients afflicted with hepatitis c using consensus interferon - Google Patents
Methods for retreatment of patients afflicted with hepatitis c using consensus interferon Download PDFInfo
- Publication number
- SK101798A3 SK101798A3 SK1017-98A SK101798A SK101798A3 SK 101798 A3 SK101798 A3 SK 101798A3 SK 101798 A SK101798 A SK 101798A SK 101798 A3 SK101798 A3 SK 101798A3
- Authority
- SK
- Slovakia
- Prior art keywords
- ifn
- patients
- treatment
- con
- interferon
- Prior art date
Links
- 102000014150 Interferons Human genes 0.000 title claims abstract description 39
- 108010050904 Interferons Proteins 0.000 title claims abstract description 39
- 229940079322 interferon Drugs 0.000 title claims abstract description 31
- 238000011268 retreatment Methods 0.000 title abstract description 15
- 238000000034 method Methods 0.000 title abstract description 10
- 208000006454 hepatitis Diseases 0.000 title description 5
- 231100000283 hepatitis Toxicity 0.000 title 1
- 238000011282 treatment Methods 0.000 claims abstract description 61
- 210000002966 serum Anatomy 0.000 claims abstract description 36
- 102100036475 Alanine aminotransferase 1 Human genes 0.000 claims description 37
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- 241000711549 Hepacivirus C Species 0.000 description 31
- 102000006992 Interferon-alpha Human genes 0.000 description 24
- 108010047761 Interferon-alpha Proteins 0.000 description 24
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 18
- 230000000694 effects Effects 0.000 description 13
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- 125000003275 alpha amino acid group Chemical group 0.000 description 6
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- 102000003996 Interferon-beta Human genes 0.000 description 2
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- 238000003556 assay Methods 0.000 description 2
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- 229960001388 interferon-beta Drugs 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 108091032955 Bacterial small RNA Proteins 0.000 description 1
- 206010008909 Chronic Hepatitis Diseases 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 108020004414 DNA Proteins 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019799 Hepatitis viral Diseases 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
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- 238000010222 PCR analysis Methods 0.000 description 1
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- 238000001631 haemodialysis Methods 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
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- 230000000322 hemodialysis Effects 0.000 description 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
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- 230000007774 longterm Effects 0.000 description 1
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- 239000012460 protein solution Substances 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010839 reverse transcription Methods 0.000 description 1
- 102200082402 rs751610198 Human genes 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
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- 230000008673 vomiting Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/595,440 US5980884A (en) | 1996-02-05 | 1996-02-05 | Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon |
| PCT/US1997/000340 WO1997027866A1 (en) | 1996-02-05 | 1997-01-13 | Methods for retreatment of patients afflicted with hepatitis c using consensus interferon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK101798A3 true SK101798A3 (en) | 2000-03-13 |
Family
ID=24383236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1017-98A SK101798A3 (en) | 1996-02-05 | 1997-01-13 | Methods for retreatment of patients afflicted with hepatitis c using consensus interferon |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5980884A (cs) |
| EP (1) | EP0879059A1 (cs) |
| JP (1) | JP2000504010A (cs) |
| KR (1) | KR19990082084A (cs) |
| CN (1) | CN1217660A (cs) |
| AU (1) | AU1531897A (cs) |
| BR (1) | BR9700829A (cs) |
| CZ (1) | CZ231998A3 (cs) |
| EA (1) | EA199800674A1 (cs) |
| HU (1) | HUP9900929A3 (cs) |
| IL (1) | IL125494A0 (cs) |
| NO (1) | NO983410L (cs) |
| SK (1) | SK101798A3 (cs) |
| WO (1) | WO1997027866A1 (cs) |
| ZA (1) | ZA97721B (cs) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69706657T2 (de) * | 1996-02-28 | 2002-06-20 | Unihart Corp., Dublin | Natürliches menschliches alpha interferon enthaltende pharmazeutische zusammensetzungen |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| EA007867B1 (ru) * | 2000-05-26 | 2007-02-27 | Айденикс (Кайман) Лимитед | Композиции для лечения флавивирусных и пестивирусных инфекций и способы их применения |
| AU2002227252A1 (en) * | 2000-12-01 | 2002-06-11 | Cornell Research Foundation | Animal model for flaviviridae infection |
| US8551469B2 (en) * | 2001-02-28 | 2013-10-08 | Superlab Far East Limited | Treatment of tumors and viral diseases with recombinant interferon alpha |
| CN1245215C (zh) * | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
| US20050079579A1 (en) * | 2001-02-28 | 2005-04-14 | Guangwen Wei | Uses of spatial configuration to modulate protein function |
| US20060035327A1 (en) * | 2001-02-28 | 2006-02-16 | Guangwen Wei | Recombinant super-compound interferon and uses thereof |
| PL369129A1 (en) * | 2001-09-28 | 2005-04-18 | Intermune, Inc. | Method for treating hepatitis c virus infection in treatment failure patients |
| WO2003028754A1 (en) * | 2001-09-28 | 2003-04-10 | Intermune, Inc. | Method for treating hepatitis c virus infection in treatment failure patients |
| WO2003026589A2 (en) * | 2001-09-28 | 2003-04-03 | Idenix (Cayman) Limited | Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides |
| MXPA04003238A (es) * | 2001-10-05 | 2004-07-08 | Intermune Inc | Metodo para tratar la infeccion de virus de hepatitis con una configuracion de suministro de interferon multifasica. |
| MXPA04003239A (es) * | 2001-10-05 | 2004-07-08 | Intermune Inc | Metodo para tratar la fibrosis hepatica y la infeccion de virus de hepatitis c. |
| EP1461067A1 (en) * | 2001-12-07 | 2004-09-29 | Intermune, Inc. | Compositions and method for treating hepatitis virus infection |
| MXPA04007876A (es) * | 2002-02-14 | 2005-06-20 | Pharmasset Ltd | Analogos de nucleosido fluorado modificados. |
| US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| US20030199464A1 (en) * | 2002-04-23 | 2003-10-23 | Silviu Itescu | Regeneration of endogenous myocardial tissue by induction of neovascularization |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| CA2489552A1 (en) | 2002-06-28 | 2004-01-08 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN104193791A (zh) | 2002-06-28 | 2014-12-10 | 埃迪尼克斯医药公司 | 用于治疗黄病毒感染的修饰的2’和3’-核苷前药 |
| CA2506129C (en) | 2002-11-15 | 2015-02-17 | Idenix (Cayman) Limited | 2'-branched nucleosides and flaviviridae mutation |
| EP1585529A4 (en) | 2002-12-12 | 2008-05-28 | Idenix Cayman Ltd | PROCESS FOR PREPARING 2'-BRANCHED NUCLEOSIDES |
| WO2004078127A2 (en) * | 2003-02-28 | 2004-09-16 | Intermune, Inc. | Continuous delivery methods for treating hepatitis virus infection |
| WO2004078194A1 (en) * | 2003-02-28 | 2004-09-16 | Intermune, Inc. | Interferon drug therapy for the treatment of viral diseases and liver fibrosis |
| PT3521297T (pt) | 2003-05-30 | 2022-03-18 | Gilead Pharmasset Llc | Análogos de nucleosídeo fluorados modificados |
| US7585647B2 (en) * | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
| ES2528218T3 (es) * | 2003-08-28 | 2015-02-05 | Superlab Far East Limited | Usos de interferones con estructura espacial modificada |
| CA2540858C (en) | 2003-10-14 | 2009-12-08 | Intermune, Inc. | Macrocyclic carboxylic acids and acylsulfonamides as inhibitors of hcv replication |
| AU2005211385B2 (en) | 2004-02-02 | 2008-12-11 | Ambrx, Inc. | Modified human growth hormone polypeptides and their uses |
| CN1980657A (zh) | 2004-05-05 | 2007-06-13 | 耶鲁大学 | 新颖的抗病毒赛菊宁黄质类似物 |
| CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
| EP1809301B1 (en) | 2004-09-14 | 2019-11-06 | Gilead Pharmasset LLC | 2-fluoro-2-alkyl-substituted d-ribonolactone intermediates |
| EP1868636A4 (en) * | 2005-03-09 | 2012-03-28 | Guangwen Wei | USE OF RECOMBINANT SUPERCOMPOSE INTERFERONS |
| EP1924594A2 (en) | 2005-07-25 | 2008-05-28 | Intermune, Inc. | Novel macrocyclic inhibitors of hepatitis c virus replication |
| EA200801050A1 (ru) | 2005-10-11 | 2008-12-30 | Интермьюн, Инк. | Соединения и способы ингибирования репликации вирусного гепатита с |
| US7781576B2 (en) | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| TW200946541A (en) * | 2008-03-27 | 2009-11-16 | Idenix Pharmaceuticals Inc | Solid forms of an anti-HIV phosphoindole compound |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| WO2010075554A1 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Synthesis of purine nucleosides |
| PA8855601A1 (es) | 2008-12-23 | 2010-07-27 | Forformidatos de nucleósidos | |
| NZ617066A (en) | 2008-12-23 | 2015-02-27 | Gilead Pharmasset Llc | Nucleoside analogs |
| TWI583692B (zh) | 2009-05-20 | 2017-05-21 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| BRPI1012951A2 (pt) * | 2009-06-09 | 2016-07-26 | Defyrus Inc | "administração de interferon para profilaxia ou tratamento de infecção por patôgeno" |
| WO2011014882A1 (en) | 2009-07-31 | 2011-02-03 | Medtronic, Inc. | CONTINUOUS SUBCUTANEOUS ADMINISTRATION OF INTERFERON-α TO HEPATITIS C INFECTED PATIENTS |
| CL2011000718A1 (es) | 2010-03-31 | 2012-04-09 | Gilead Pharmasset Llc | Proceso para la preparacion de compuestos fosforados enantiomericos. |
| US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
| US20120123338A1 (en) | 2010-06-16 | 2012-05-17 | Medtronic, Inc. | Damping systems for stabilizing medications in drug delivery devices |
| WO2012075140A1 (en) | 2010-11-30 | 2012-06-07 | Pharmasset, Inc. | Compounds |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| MX2014004729A (es) | 2011-10-21 | 2014-07-28 | Abbvie Inc | Tratamiento en combinacion (por ejemplo, con abt-072 o abt-333) de agentes antivirales de accion directa para utilizarse en el tratamiento del virus de la hepatitis c. |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| US8809354B2 (en) | 2011-12-31 | 2014-08-19 | Sheikh Riazuddin | 3-amino-2-(4-nitrophenyl)-4-(3H)-quinazolinone or derivatives thereof for treating or preventing antiviral infections |
| TWI718086B (zh) | 2013-01-07 | 2021-02-11 | 英屬維爾京群島商遠東超級實驗室有限公司 | 通過干擾素的經皮和/或經粘膜給藥治療骨癌、皮膚癌、皮下癌、粘膜癌和/或粘膜下癌的方法和組合物 |
| SG11201600919UA (en) | 2013-08-27 | 2016-03-30 | Gilead Pharmasset Llc | Combination formulation of two antiviral compounds |
| CN109689063A (zh) | 2016-04-28 | 2019-04-26 | 埃默里大学 | 含有炔烃的核苷酸和核苷治疗组合物及其相关用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| US5372808A (en) * | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
-
1996
- 1996-02-05 US US08/595,440 patent/US5980884A/en not_active Expired - Lifetime
-
1997
- 1997-01-13 AU AU15318/97A patent/AU1531897A/en not_active Abandoned
- 1997-01-13 WO PCT/US1997/000340 patent/WO1997027866A1/en not_active Application Discontinuation
- 1997-01-13 EP EP97901413A patent/EP0879059A1/en not_active Withdrawn
- 1997-01-13 JP JP9527645A patent/JP2000504010A/ja active Pending
- 1997-01-13 CN CN97193506A patent/CN1217660A/zh active Pending
- 1997-01-13 CZ CZ982319A patent/CZ231998A3/cs unknown
- 1997-01-13 IL IL12549497A patent/IL125494A0/xx unknown
- 1997-01-13 KR KR1019980705806A patent/KR19990082084A/ko not_active Ceased
- 1997-01-13 HU HU9900929A patent/HUP9900929A3/hu unknown
- 1997-01-13 EA EA199800674A patent/EA199800674A1/ru unknown
- 1997-01-13 SK SK1017-98A patent/SK101798A3/sk unknown
- 1997-01-29 ZA ZA9700721A patent/ZA97721B/xx unknown
- 1997-01-30 BR BR9700829A patent/BR9700829A/pt active Search and Examination
-
1998
- 1998-07-23 NO NO983410A patent/NO983410L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL125494A0 (en) | 1999-03-12 |
| US5980884A (en) | 1999-11-09 |
| HUP9900929A3 (en) | 1999-11-29 |
| NO983410L (no) | 1998-10-05 |
| WO1997027866A1 (en) | 1997-08-07 |
| HUP9900929A2 (hu) | 1999-07-28 |
| CZ231998A3 (cs) | 1999-03-17 |
| NO983410D0 (no) | 1998-07-23 |
| EP0879059A1 (en) | 1998-11-25 |
| AU1531897A (en) | 1997-08-22 |
| KR19990082084A (ko) | 1999-11-15 |
| ZA97721B (en) | 1997-08-01 |
| JP2000504010A (ja) | 2000-04-04 |
| EA199800674A1 (ru) | 1999-02-25 |
| BR9700829A (pt) | 1998-07-07 |
| CN1217660A (zh) | 1999-05-26 |
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