SI9520073B - Novi celični sistemi, ki imajo specifično interakcijo peptidnih veznih parov - Google Patents
Novi celični sistemi, ki imajo specifično interakcijo peptidnih veznih parov Download PDFInfo
- Publication number
- SI9520073B SI9520073B SI9520073A SI9520073A SI9520073B SI 9520073 B SI9520073 B SI 9520073B SI 9520073 A SI9520073 A SI 9520073A SI 9520073 A SI9520073 A SI 9520073A SI 9520073 B SI9520073 B SI 9520073B
- Authority
- SI
- Slovenia
- Prior art keywords
- peptide
- host cell
- protein
- fusion protein
- transcriptional activation
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 58
- 230000027455 binding Effects 0.000 title claims abstract 31
- 230000003993 interaction Effects 0.000 title claims 5
- 108090000623 proteins and genes Proteins 0.000 claims abstract 56
- 108020001507 fusion proteins Proteins 0.000 claims abstract 30
- 102000037865 fusion proteins Human genes 0.000 claims abstract 30
- 230000029279 positive regulation of transcription, DNA-dependent Effects 0.000 claims abstract 26
- 102000004169 proteins and genes Human genes 0.000 claims abstract 25
- 238000000034 method Methods 0.000 claims abstract 17
- 108700008625 Reporter Genes Proteins 0.000 claims abstract 11
- 239000013611 chromosomal DNA Substances 0.000 claims abstract 4
- 238000012217 deletion Methods 0.000 claims abstract 4
- 230000037430 deletion Effects 0.000 claims abstract 4
- 230000035772 mutation Effects 0.000 claims abstract 4
- 230000004568 DNA-binding Effects 0.000 claims abstract 3
- 210000004027 cell Anatomy 0.000 claims 53
- 108020003175 receptors Proteins 0.000 claims 16
- 102000005962 receptors Human genes 0.000 claims 16
- 230000000694 effects Effects 0.000 claims 12
- 108020004414 DNA Proteins 0.000 claims 11
- 238000005897 peptide coupling reaction Methods 0.000 claims 11
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 9
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 9
- 239000003446 ligand Substances 0.000 claims 9
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 239000013612 plasmid Substances 0.000 claims 5
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 108091006027 G proteins Proteins 0.000 claims 3
- 102000030782 GTP binding Human genes 0.000 claims 3
- 108091000058 GTP-Binding Proteins 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 239000003102 growth factor Substances 0.000 claims 3
- 238000013518 transcription Methods 0.000 claims 3
- 230000035897 transcription Effects 0.000 claims 3
- 230000001131 transforming effect Effects 0.000 claims 3
- 210000005253 yeast cell Anatomy 0.000 claims 3
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 2
- 108010058643 Fungal Proteins Proteins 0.000 claims 2
- 102100039556 Galectin-4 Human genes 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000009151 Luteinizing Hormone Human genes 0.000 claims 2
- 108010073521 Luteinizing Hormone Proteins 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 230000004913 activation Effects 0.000 claims 2
- 230000000890 antigenic effect Effects 0.000 claims 2
- 230000008859 change Effects 0.000 claims 2
- 230000000295 complement effect Effects 0.000 claims 2
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 2
- 230000002519 immonomodulatory effect Effects 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 108010045747 interleukin 3 receptor-like molecule Proteins 0.000 claims 2
- 229940040129 luteinizing hormone Drugs 0.000 claims 2
- 108091008875 B cell receptors Proteins 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 102000016289 Cell Adhesion Molecules Human genes 0.000 claims 1
- 108010067225 Cell Adhesion Molecules Proteins 0.000 claims 1
- 108010035563 Chloramphenicol O-acetyltransferase Proteins 0.000 claims 1
- 102100021809 Chorionic somatomammotropin hormone 1 Human genes 0.000 claims 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims 1
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims 1
- 108020004635 Complementary DNA Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 101000799969 Escherichia coli (strain K12) Alpha-2-macroglobulin Proteins 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- 108010001515 Galectin 4 Proteins 0.000 claims 1
- 102000051325 Glucagon Human genes 0.000 claims 1
- 108060003199 Glucagon Proteins 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 102000017178 Guanylate Cyclase-Coupled Receptors Human genes 0.000 claims 1
- 108010013990 Guanylate Cyclase-Coupled Receptors Proteins 0.000 claims 1
- 108010068250 Herpes Simplex Virus Protein Vmw65 Proteins 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000895818 Homo sapiens Chorionic somatomammotropin hormone 1 Proteins 0.000 claims 1
- 101000956228 Homo sapiens Chorionic somatomammotropin hormone 2 Proteins 0.000 claims 1
- 101000608765 Homo sapiens Galectin-4 Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 102000004890 Interleukin-8 Human genes 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 241000235058 Komagataella pastoris Species 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 108060001084 Luciferase Proteins 0.000 claims 1
- 239000005089 Luciferase Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000004140 Oncostatin M Human genes 0.000 claims 1
- 108090000630 Oncostatin M Proteins 0.000 claims 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
- 102100024819 Prolactin Human genes 0.000 claims 1
- 108010057464 Prolactin Proteins 0.000 claims 1
- 101150005828 SWI5 gene Proteins 0.000 claims 1
- 102100037505 Secretin Human genes 0.000 claims 1
- 108010086019 Secretin Proteins 0.000 claims 1
- 102000003800 Selectins Human genes 0.000 claims 1
- 108090000184 Selectins Proteins 0.000 claims 1
- 102100038803 Somatotropin Human genes 0.000 claims 1
- 102000015215 Stem Cell Factor Human genes 0.000 claims 1
- 108010039445 Stem Cell Factor Proteins 0.000 claims 1
- 108091008874 T cell receptors Proteins 0.000 claims 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 102000011923 Thyrotropin Human genes 0.000 claims 1
- 108010061174 Thyrotropin Proteins 0.000 claims 1
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 claims 1
- 230000009471 action Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 210000001772 blood platelet Anatomy 0.000 claims 1
- 238000010804 cDNA synthesis Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000002299 complementary DNA Substances 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 230000003511 endothelial effect Effects 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
- 229960004666 glucagon Drugs 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 230000010005 growth-factor like effect Effects 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 102000006495 integrins Human genes 0.000 claims 1
- 108010044426 integrins Proteins 0.000 claims 1
- 229940047124 interferons Drugs 0.000 claims 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 1
- 229940096397 interleukin-8 Drugs 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- 101150066555 lacZ gene Proteins 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 230000002956 necrotizing effect Effects 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000000813 peptide hormone Substances 0.000 claims 1
- 102000014187 peptide receptors Human genes 0.000 claims 1
- 108010011903 peptide receptors Proteins 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 229940097325 prolactin Drugs 0.000 claims 1
- AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 claims 1
- 210000003370 receptor cell Anatomy 0.000 claims 1
- 230000003362 replicative effect Effects 0.000 claims 1
- 229960002101 secretin Drugs 0.000 claims 1
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229960000874 thyrotropin Drugs 0.000 claims 1
- 230000001748 thyrotropin Effects 0.000 claims 1
- 230000002103 transcriptional effect Effects 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 230000002227 vasoactive effect Effects 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Mobile Radio Communication Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/259,609 US5989808A (en) | 1994-06-14 | 1994-06-14 | Identification of compounds affecting specific interaction of peptide binding pairs |
| PCT/US1995/006895 WO1995034646A1 (en) | 1994-06-14 | 1995-05-31 | Novel cell systems having specific interaction of peptide binding pairs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI9520073A SI9520073A (sl) | 1998-02-28 |
| SI9520073B true SI9520073B (sl) | 2004-06-30 |
Family
ID=22985626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9520073A SI9520073B (sl) | 1994-06-14 | 1995-05-31 | Novi celični sistemi, ki imajo specifično interakcijo peptidnih veznih parov |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US5989808A (da) |
| EP (1) | EP0765389B1 (da) |
| AT (1) | ATE245189T1 (da) |
| AU (1) | AU706173B2 (da) |
| CA (1) | CA2195083A1 (da) |
| DE (1) | DE69531302T2 (da) |
| DK (1) | DK0765389T3 (da) |
| ES (1) | ES2202366T3 (da) |
| GE (1) | GEP20022619B (da) |
| IL (1) | IL114118A0 (da) |
| LT (1) | LT4230B (da) |
| LV (1) | LV11906B (da) |
| NZ (1) | NZ287372A (da) |
| PT (1) | PT765389E (da) |
| RU (1) | RU2208646C2 (da) |
| SI (1) | SI9520073B (da) |
| WO (1) | WO1995034646A1 (da) |
| ZA (1) | ZA954892B (da) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7226761B2 (en) * | 1992-11-05 | 2007-06-05 | Danisco Sweeteners Oy | Manufacture of five-carbon sugars and sugar alcohols |
| US6891021B2 (en) | 1993-02-12 | 2005-05-10 | Board Of Trustees Of The Leland Stanford Junior University | Regulated apoptosis |
| US6972193B1 (en) * | 1993-02-12 | 2005-12-06 | Board Of Trustees Of Leland Stanford Junior University | Regulated transcription of targeted genes and other biological events |
| US6770446B1 (en) * | 1994-06-14 | 2004-08-03 | Wyeth | Cell systems having specific interaction of peptide binding pairs |
| US5610015A (en) * | 1995-03-23 | 1997-03-11 | Wisconsin Alumni Research Foundation | System to detect protein-RNA interactions |
| AU716893B2 (en) * | 1995-04-11 | 2000-03-09 | General Hospital Corporation, The | Reverse two-hybrid systems |
| US5837844A (en) * | 1995-06-07 | 1998-11-17 | Biogen, Inc. | CAIP-like gene family |
| US6423824B1 (en) | 1995-06-07 | 2002-07-23 | Biogen, Inc. | CAIP-like gene family |
| US6171800B1 (en) | 1995-06-07 | 2001-01-09 | Biogen, Inc. | Method of making and binding CAIP polypeptides |
| DE29724617U1 (de) * | 1996-04-26 | 2002-06-13 | Massachusetts Institute Of Technology, Cambridge, Mass. | Drei-Hybrid-Kit zur Molekülauswahl |
| JP2000508923A (ja) * | 1996-04-26 | 2000-07-18 | マサチューセッツ・インスティテュート・オブ・テクノロジー | ３―ハイブリッド・スクリーニング・アッセイ |
| US6696251B1 (en) | 1996-05-31 | 2004-02-24 | Board Of Trustees Of The University Of Illinois | Yeast cell surface display of proteins and uses thereof |
| WO1997049808A1 (en) * | 1996-06-27 | 1997-12-31 | Biogen, Inc. | The caip-like gene family |
| FR2761697B1 (fr) * | 1997-04-03 | 1999-05-28 | Inst Nat Sante Rech Med | Methodes de detection d'interactions entre plusieurs proteines |
| DE19715683C2 (de) * | 1997-04-15 | 1999-11-11 | Max Planck Gesellschaft | Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme |
| US7005295B1 (en) | 1997-04-16 | 2006-02-28 | Wyeth | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
| US6787319B2 (en) | 1997-04-16 | 2004-09-07 | American Home Products Corp. | β-amyloid peptide-binding proteins and polynucleotides encoding the same |
| PT977846E (pt) | 1997-04-25 | 2002-11-29 | Wyeth Corp | Isoformas de morti neuronal |
| US6479653B1 (en) | 1997-08-26 | 2002-11-12 | Ariad Gene Therapeutics, Inc. | Compositions and method for regulation of transcription |
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| ES2202366T3 (es) | 2004-04-01 |
| PT765389E (pt) | 2003-11-28 |
| US5989808A (en) | 1999-11-23 |
| CA2195083A1 (en) | 1995-12-21 |
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| DK0765389T3 (da) | 2003-10-27 |
| RU2208646C2 (ru) | 2003-07-20 |
| EP0765389B1 (en) | 2003-07-16 |
| ZA954892B (en) | 1996-01-30 |
| LV11906A (lv) | 1997-12-20 |
| LT97004A (en) | 1997-07-25 |
| WO1995034646A1 (en) | 1995-12-21 |
| SI9520073A (sl) | 1998-02-28 |
| US6284519B1 (en) | 2001-09-04 |
| DE69531302D1 (de) | 2003-08-21 |
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