SI8912423B - Novi derivati ksantina z antagonističnim učinkom proti adenozinu - Google Patents

Novi derivati ksantina z antagonističnim učinkom proti adenozinu Download PDF

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Publication number
SI8912423B
SI8912423B SI8912423A SI8912423A SI8912423B SI 8912423 B SI8912423 B SI 8912423B SI 8912423 A SI8912423 A SI 8912423A SI 8912423 A SI8912423 A SI 8912423A SI 8912423 B SI8912423 B SI 8912423B
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SI
Slovenia
Prior art keywords
substd
opt
alkyl
general formula
compound
Prior art date
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SI8912423A
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English (en)
Slovenian (sl)
Other versions
SI8912423A (sl
Inventor
Ulrike Kuefner-Muehl
Karl-Heinz Weber
Gerhard Walther
Werner Stransky
Helmut Ensinger
Guenter Schingnitz
Franz Josef Kuhn
Erich Lehr
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of SI8912423A publication Critical patent/SI8912423A/sl
Publication of SI8912423B publication Critical patent/SI8912423B/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SI8912423A 1988-12-22 1989-12-20 Novi derivati ksantina z antagonističnim učinkom proti adenozinu SI8912423B (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3843117A DE3843117A1 (de) 1988-12-22 1988-12-22 Neue xanthinderivate mit adenosin-antagonistischer wirkung
YU242389A YU47934B (sh) 1988-12-22 1989-12-20 Novi derivati ksantina sa antagonističnim dejstvom prema adenziju

Publications (2)

Publication Number Publication Date
SI8912423A SI8912423A (sl) 1998-04-30
SI8912423B true SI8912423B (sl) 1998-12-31

Family

ID=6369764

Family Applications (1)

Application Number Title Priority Date Filing Date
SI8912423A SI8912423B (sl) 1988-12-22 1989-12-20 Novi derivati ksantina z antagonističnim učinkom proti adenozinu

Country Status (32)

Country Link
US (4) US5175291A (pl)
EP (1) EP0374808B1 (pl)
JP (1) JP2565576B2 (pl)
KR (1) KR0165666B1 (pl)
AT (1) ATE136897T1 (pl)
BG (1) BG61669B2 (pl)
BR (1) BR1100527A (pl)
CA (1) CA2006387C (pl)
CZ (1) CZ286230B6 (pl)
DD (1) DD290421A5 (pl)
DE (3) DE3843117A1 (pl)
DK (1) DK652689A (pl)
ES (1) ES2086313T3 (pl)
FI (1) FI96513C (pl)
GR (1) GR3019733T3 (pl)
HR (1) HRP940724A2 (pl)
HU (1) HU218674B (pl)
IE (1) IE74205B1 (pl)
IL (1) IL92829A (pl)
MX (1) MX9203618A (pl)
NO (1) NO173502C (pl)
NZ (1) NZ231901A (pl)
PH (2) PH31107A (pl)
PL (1) PL162877B1 (pl)
PT (1) PT92658B (pl)
RU (1) RU2057752C1 (pl)
SG (1) SG46380A1 (pl)
SI (1) SI8912423B (pl)
SK (1) SK719789A3 (pl)
UA (1) UA26427A (pl)
YU (1) YU47934B (pl)
ZA (1) ZA899881B (pl)

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JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
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TW252044B (pl) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
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DE4316576A1 (de) * 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
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JP3769737B2 (ja) * 1994-03-30 2006-04-26 味の素株式会社 シクロプロパン誘導体及びその製造法
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JP2001523213A (ja) * 1994-12-13 2001-11-20 ユーロ−セルティーク，エス．エイ． 三置換チオキサンチン類
US5864037A (en) 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
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US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
US6545002B1 (en) 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
PT1230241E (pt) * 1999-11-12 2007-05-31 Biogen Idec Inc Antagonistas do receptor de adenosina e métodos de fabrico e uso dos mesmos
BR0015545A (pt) * 1999-11-12 2002-08-06 Biogen Inc Policicloalquilpurinas como antagonistas dos receptores para adenosina
US7087589B2 (en) 2000-01-14 2006-08-08 The United States Of America As Represented By The Department Of Health And Human Services Methanocarba cycloakyl nucleoside analogues
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BRPI0909157A2 (pt) * 2008-03-26 2015-11-24 Advinus Therapeutics Private Ltd compostos heterocíclicos como antagonistas de receptores de adenosina
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US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
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Also Published As

Publication number Publication date
SI8912423A (sl) 1998-04-30
IE74205B1 (en) 1997-07-16
NO173502C (no) 1993-12-22
HRP940724A2 (en) 1997-06-30
PL162877B1 (pl) 1994-01-31
EP0374808B1 (de) 1996-04-17
AU637990B2 (en) 1993-06-17
HU896736D0 (en) 1990-02-28
ZA899881B (en) 1991-08-28
NO895168D0 (no) 1989-12-21
PH31111A (en) 1998-02-23
UA26427A (uk) 1999-08-30
EP0374808A2 (de) 1990-06-27
FI896117A0 (fi) 1989-12-20
CZ286230B6 (cs) 2000-02-16
PT92658B (pt) 1995-09-12
DK652689D0 (da) 1989-12-21
DD290421A5 (de) 1991-05-29
NO895168L (no) 1990-06-25
CZ719789A3 (cs) 1999-10-13
PT92658A (pt) 1990-06-29
CA2006387C (en) 2000-02-08
PH31107A (en) 1998-02-23
PL282878A1 (en) 1992-03-09
SG46380A1 (en) 1998-02-20
US5696124A (en) 1997-12-09
DE58909657D1 (de) 1996-05-23
NZ231901A (en) 1993-12-23
US5175291A (en) 1992-12-29
BR1100527A (pt) 2000-08-01
HU218674B (hu) 2000-10-28
IL92829A (en) 1995-12-31
KR0165666B1 (ko) 1999-01-15
YU242389A (en) 1991-10-31
GR3019733T3 (en) 1996-07-31
SK279525B6 (sk) 1998-12-02
ATE136897T1 (de) 1996-05-15
JP2565576B2 (ja) 1996-12-18
EP0374808A3 (de) 1991-05-15
BG61669B2 (bg) 1998-02-27
MX9203618A (es) 1992-09-01
AU4707289A (en) 1990-06-28
NO173502B (no) 1993-09-13
FI96513C (fi) 1996-07-10
US5532368A (en) 1996-07-02
DE8817122U1 (de) 1993-02-04
KR900009646A (ko) 1990-07-05
US5688802A (en) 1997-11-18
SK719789A3 (en) 1998-12-02
RU2057752C1 (ru) 1996-04-10
DE3843117A1 (de) 1990-06-28
YU47934B (sh) 1996-05-20
CA2006387A1 (en) 1990-06-22
JPH02247180A (ja) 1990-10-02
IE894147L (en) 1990-06-22
ES2086313T3 (es) 1996-07-01
DK652689A (da) 1990-06-23
HUT52503A (en) 1990-07-28
IL92829A0 (en) 1990-09-17
FI96513B (fi) 1996-03-29

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