SI8911362A - Process for lactonization of mevinic acids and analogs thereof - Google Patents

Process for lactonization of mevinic acids and analogs thereof Download PDF

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Publication number
SI8911362A
SI8911362A SI8911362A SI8911362A SI8911362A SI 8911362 A SI8911362 A SI 8911362A SI 8911362 A SI8911362 A SI 8911362A SI 8911362 A SI8911362 A SI 8911362A SI 8911362 A SI8911362 A SI 8911362A
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SI
Slovenia
Prior art keywords
alkyl
process according
acid
water
compound
Prior art date
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SI8911362A
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English (en)
Slovenian (sl)
Inventor
R Laszlo Treiber
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22827965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI8911362(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SI8911362A publication Critical patent/SI8911362A/sl

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
SI8911362A 1988-07-19 1989-07-10 Process for lactonization of mevinic acids and analogs thereof SI8911362A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/221,475 US4916239A (en) 1988-07-19 1988-07-19 Process for the lactonization of mevinic acids and analogs thereof
YU136289A YU47492B (sh) 1988-07-19 1989-07-10 Postupak za laktonizaciju mevinskih kiselina i analoga istih

Publications (1)

Publication Number Publication Date
SI8911362A true SI8911362A (en) 1997-02-28

Family

ID=22827965

Family Applications (1)

Application Number Title Priority Date Filing Date
SI8911362A SI8911362A (en) 1988-07-19 1989-07-10 Process for lactonization of mevinic acids and analogs thereof

Country Status (26)

Country Link
US (1) US4916239A (fr)
EP (1) EP0351918B1 (fr)
JP (3) JPH0273078A (fr)
KR (1) KR970011286B1 (fr)
CN (1) CN1022831C (fr)
AT (1) ATE111459T1 (fr)
AU (1) AU609319B2 (fr)
CA (1) CA1287639C (fr)
CS (1) CS274640B2 (fr)
CY (1) CY1813A (fr)
DE (1) DE68918191C5 (fr)
DK (1) DK173115B1 (fr)
ES (1) ES2058475T3 (fr)
FI (1) FI92695C (fr)
HK (1) HK136894A (fr)
HR (1) HRP930685B2 (fr)
HU (2) HU202511B (fr)
IE (1) IE64304B1 (fr)
IL (1) IL90925A (fr)
LV (1) LV11033B (fr)
NO (1) NO172800C (fr)
NZ (1) NZ229879A (fr)
PT (1) PT91191B (fr)
SI (1) SI8911362A (fr)
YU (1) YU47492B (fr)
ZA (1) ZA895458B (fr)

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* Cited by examiner, † Cited by third party
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US5250435A (en) * 1991-06-04 1993-10-05 Merck & Co., Inc. Mutant strains of Aspergillus terreus for producing 7-[1,2,6,7,8,8a(R)-hexa-hydro-2(S),6(R)-dimethyl-8(S)-hydroxy-1(S)-naphthyl]-3(R),5(R)-dihydroxyheptanoic acid (triol acid),I)
AU660132B2 (en) * 1992-12-21 1995-06-08 Bayer Aktiengesellschaft Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridine
SG45369A1 (en) * 1993-01-19 1998-10-16 Warner Lambert Co Stable oral ci-981 formulation and process of preparing same
IN186879B (fr) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
IN186880B (fr) * 1997-10-28 2001-12-01 Ranbaxy Lab Ltd
ZA9810764B (en) * 1998-04-22 1999-08-13 Ranbaxy Lab Ltd An improved process of lactonization in the preparation of statins.
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EP1110959A4 (fr) * 1999-06-29 2001-12-05 Kaneka Corp Procede de lactonisation selective
AU8030900A (en) 1999-10-27 2001-05-08 Merck & Co., Inc. Lactonization process
SK13782002A3 (sk) 2000-03-03 2004-02-03 Plus Chemicals, S.A. Spôsob čistenia lovastatínu a simvastatínu na produkt so zníženou hladinou dimerných nečistôt
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Also Published As

Publication number Publication date
DE68918191C5 (de) 2005-06-09
NZ229879A (en) 1991-12-23
HU202511B (en) 1991-03-28
CN1022831C (zh) 1993-11-24
PT91191A (pt) 1990-02-08
JP2718422B2 (ja) 1998-02-25
DK173115B1 (da) 2000-01-31
NO172800C (no) 1993-09-08
ATE111459T1 (de) 1994-09-15
EP0351918B1 (fr) 1994-09-14
IE892324L (en) 1990-01-19
KR910002828A (ko) 1991-02-26
JPH07196642A (ja) 1995-08-01
CY1813A (en) 1995-10-20
FI893363A (fi) 1990-01-20
FI893363A0 (fi) 1989-07-11
DK354189D0 (da) 1989-07-18
NO172800B (no) 1993-06-01
IL90925A0 (en) 1990-02-09
DK354189A (da) 1990-01-22
HRP930685A2 (en) 1998-06-30
AU609319B2 (en) 1991-04-26
JPH09188672A (ja) 1997-07-22
FI92695C (fi) 1994-12-27
LV11033B (en) 1996-06-20
PT91191B (pt) 1995-03-01
IL90925A (en) 1993-04-04
IE892324A1 (en) 1991-06-19
FI92695B (fi) 1994-09-15
DE68918191T2 (de) 1995-03-02
CS274640B2 (en) 1991-09-15
HRP930685B2 (hr) 2006-11-30
JPH0273078A (ja) 1990-03-13
NO892938L (no) 1990-01-22
HK136894A (en) 1994-12-09
YU47492B (sh) 1995-10-03
CS435489A2 (en) 1990-12-13
IE64304B1 (en) 1995-07-26
AU3824089A (en) 1990-01-25
DE68918191D1 (de) 1994-10-20
HU210533A9 (en) 1995-04-28
CA1287639C (fr) 1991-08-13
ZA895458B (en) 1990-03-28
NO892938D0 (no) 1989-07-17
US4916239A (en) 1990-04-10
EP0351918A1 (fr) 1990-01-24
HRP930685B1 (en) 1999-06-30
JPH0575752B2 (fr) 1993-10-21
YU136289A (en) 1991-02-28
CN1039420A (zh) 1990-02-07
ES2058475T3 (es) 1994-11-01
HUT50804A (en) 1990-03-28
KR970011286B1 (ko) 1997-07-09
LV11033A (lv) 1996-02-20

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